<\/a><\/p>\n \n <\/p>\n<\/div>\n
ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u60272\u671f\u7814\u7a76\u3002\u961f\u52171-3\u65e8\u5728\u8bc4\u4f30elebsiran\uff08\u4e00\u79cd\u7814\u7a76\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\uff09\u5728\u4e0e\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u8054\u5408\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\uff08\u57fa\u7ebf\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u4e3a100-3,000 IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n
\u961f\u52174\u5165\u7ec4\u4e86\u5728\u5148\u524d\u7684\u4e9a\u592a\u5730\u533a\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u8fc79\u5242BRII-179\uff08\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u8054\u5408elebsiran\u7ed9\u836f\u7684\u53c2\u4e0e\u8005\uff0c\u63a5\u53d7elebsiran\u4e0ePEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u3002\u8fd9\u4e9b\u53c2\u4e0e\u8005\u6839\u636e\u4ed6\u4eec\u4e4b\u524d\u63a5\u53d7 BRII-179 \u6cbb\u7597\u540e\u4ea7\u751f\u7684\u6297HBs\u5e94\u7b54\u8fdb\u884c\u5206\u7ec4\uff1a\u6297HBs\u6ef4\u5ea6\u5cf0\u503c \u2265 10 IU\/L\u7684\u53c2\u4e0e\u8005\u88ab\u5b9a\u4e49\u4e3a\u6297HBs\u5e94\u7b54\u8005\uff0c\u6297HBs\u6ef4\u5ea6\u5cf0\u503c < 10 IU\/L \u7684\u53c2\u4e0e\u8005\u88ab\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\u3002\u672c\u7814\u7a76\u961f\u5217 4 \u7684\u8bbe\u8ba1\u57fa\u4e8eBRII-179\u53ef\u4ee5\u533a\u5206\u514d\u75ab\u5e94\u7b54\u8005\u548c\u65e0\u5e94\u7b54\u8005\u7684\u4e00\u79cd\u89c1\u89e3\uff0c\u4ece\u800c\u4e3a\u9884\u6d4b\u672a\u6765\u7684\u6cbb\u7597\u5e94\u7b54\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002<\/p>\n
\u961f\u52174\u7684\u4e2d\u671f\u6570\u636e\u663e\u793a\uff0c\u6297HBs\u5e94\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u663e\u8457\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\u3002EOT\uff08\u7b2c48\u5468\uff09\u65f6\uff0c61%\uff0811\/18\uff09\u7684\u6297HBs\u5e94\u7b54\u8005\u8fbe\u5230HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e3a10%\uff081\/10\uff09\u3002\u572811\u540d\u5b9e\u73b0HBsAg\u6e05\u9664\u7684\u6297HBs\u5e94\u7b54\u8005\u4e2d\uff0c91%\uff0810\/11\uff09\u5728EOT\u65f6\u7684\u6297HBs\u6ef4\u5ea6\u2265100 IU\/L\u3002<\/p>\n
\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c \u961f\u52174\u4e2d\u7684BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u6bd4\u961f\u52172\u548c\u961f\u52173\u4e2dBRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u66f4\u5feb\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u7b2c24\u5468\u65f6\u5728BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e2d\u5df2\u670983%\uff0810\/12\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u800cBRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e3a55% \uff086\/11\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5feb\u901f\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548c\u8f83\u9ad8\u7684\u6297HBs\u6ef4\u5ea6\u53ef\u8f6c\u5316\u4e3a\u6301\u4e45\u7684HBsAg\u6e05\u9664\uff0c\u4ee5\u53ca\u8bc4\u4f30\u7f29\u77edPEG-IFN\u03b1\u7597\u7a0b\u7684\u53ef\u80fd\u6027\u3002<\/p>\n
ENSURE\u7814\u7a76\u961f\u52171-3\u7684\u5176\u4ed6\u6570\u636e\u8868\u660e\uff0c\u4e0ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c100\u6216200 \u6beb\u514belebsiran\u4e0ePEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u5728EOT24\u5468\u540e\u5747\u53ef\u5b9e\u73b0\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387\uff0c\u652f\u6301siRNA\u7684\u989d\u5916\u83b7\u76ca\u3002<\/p>\n
\u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a”ENSURE\u7814\u7a76\u961f\u52174\u7684\u6570\u636e\u4ee4\u4eba\u9f13\u821e\u3002\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u53d1\u73b0\uff0c\u7ecf\u8fc7BRII-179\u9884\u6cbb\u7597\u4ea7\u751f\u514d\u75ab\u5e94\u7b54\u7684\u60a3\u8005\u5728\u5b9e\u73b0\u8f83\u9ad8\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u4f18\u52bf\u3002\u501f\u52a9BRII-179\uff0c\u6211\u4eec\u53ef\u4ee5\u8bc6\u522b\u5185\u5728\u514d\u75ab\u53d7\u635f\u7a0b\u5ea6\u8f83\u4f4e\u7684\u60a3\u8005\uff0c\u5e76\u8fdb\u4e00\u6b65\u589e\u5f3a\u5176\u514d\u75ab\u5e94\u7b54\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4f7f HBsAg \u6e05\u9664\u66f4\u6301\u4e45\uff0c\u5e76\u6709\u53ef\u80fd\u7f29\u77ed PEG-IFN\u03b1\u7684\u6cbb\u7597\u65f6\u95f4\u3002\u6211\u4eec\u6b63\u5728\u5168\u901f\u63a8\u8fdb\u4e34\u5e8a\u5de5\u4f5c\uff0c\u4ee5\u671f\u4e3a\u6162\u6027\u4e59\u578b\u809d\u708e\u60a3\u8005\u63d0\u4f9b\u6709\u610f\u4e49\u7684\u53ef\u9009\u65b9\u6848\u3002”<\/p>\n
\u6458\u8981\u7f16\u53f7\uff1aLB25123\/ LBP-018<\/span>
\u6807\u9898\uff1a\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u4ea7\u751f\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u53c2\u4e0e\u8005\u5728\u63a5\u53d7elebsiran \u548c PEG-IFN\u03b1 \u6cbb\u7597\u540e\u53ef\u83b7\u5f97\u66f4\u5feb\u66f4\u9ad8\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u6e05\u9664\u7387\uff1a\u6765\u81eaENSURE\u7814\u7a76\u7684\u6cbb\u7597\u7ed3\u675f\u65f6\u6570\u636e
\u4e3b\u8bb2\u4eba\uff1a\u9ec4\u4e3d\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a<\/p>\n\u5171\u5206\u6790\u4e8628\u4f8b\u57fa\u7ebfHBsAg > 100\u548c\u2264 3000 IU\/mL\u7684\u53c2\u4e0e\u8005\u3002\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\uff0cBRII-179\u8bf1\u5bfc\u768418\u4f8b\u53c2\u4e0e\u8005\u7684\u6297HBs\u6ef4\u5ea6\u5cf0\u503c\u2265 10 IU\/L\uff08\u5b9a\u4e49\u4e3a\u6297HBs\u5e94\u7b54\u8005\uff09\u548c10\u4f8b\u53c2\u4e0e\u8005< 10 IU\/L\uff08\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\uff09\u3002\u5728\u5f00\u59cbelebsiran + PEG-IFN\u03b1\u6cbb\u7597\u65f6\uff0c\u6297HBs\u5e94\u7b54\u8005\uff08539.4 [106.7-2165.0] IU\/mL\uff09\u7684HBsAg\u4e2d\u4f4d\u6570\uff08\u8303\u56f4\uff09\u5728\u6570\u503c\u4e0a\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\uff08219.3 [106.7-671.5] IU\/mL\uff09\u3002EOT\uff08\u7b2c48\u5468\uff09\u65f6\uff0c61%\uff0811\/18\uff09\u7684\u6297HBs\u5e94\u7b54\u8005\u8fbe\u5230HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e3a10%\uff081\/10\uff09\u3002\u5728HBsAg\u8f6c\u9634\u7684\u6297HBs\u5e94\u7b54\u8005\u4e2d\uff0c91%\uff0810\/11\uff09\u5728EOT\u65f6\u7684\u6297HBs\u6ef4\u5ea6\u2265100 IU\/L\u3002BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u6bd4BRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u66f4\u5feb\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u7b2c24\u5468\u65f6\u5df2\u670983%\uff0810\/12\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0HBsAg\u6e05\u9664\uff08BRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e3a55% \uff086\/11\uff09\uff09\u3002Elebsiran + PEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u5728BRII-179\u7ecf\u6cbb\u7684\u53c2\u4e0e\u8005\u4e2d\u603b\u4f53\u5b89\u5168\u4e14\u53ef\u8010\u53d7\u3002<\/p>\n
\u6458\u8981\u7f16\u53f7\uff1aLB25115\/ LBP-016<\/span>
\u6807\u9898\uff1aElebsiran \u548c PEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u4e0ePEG-IFN\u03b1\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u53c2\u4e0e\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff1a\u6b63\u5728\u8fdb\u884c\u76842\u671f\u3001\u968f\u673a\u3001\u5f00\u653e\u6027ENSURE\u7814\u7a76\u7684\u968f\u8bbf\u7ed3\u679c
\u4e3b\u8bb2\u4eba\uff1aDavid Margolis\uff0cM.D.\uff0cMPH\uff0c\u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98<\/p>\n\u7b2c72\u5468\uff08EOT\u540e24\u5468\uff09\u65f6\uff0c\u4e0ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u5728\u63a5\u53d7elebsiran 200 mg\u6216100 mg\u4e0ePEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u89c2\u5bdf\u5230\u66f4\u9ad8\u7684HBsAg\u8f6c\u9634\u7387\uff0821.1% [4\/19]\u621633.3% [6\/18] vs 5.6% [1\/18]\uff09\uff0c\u6240\u670911\u4f8b\u5b9e\u73b0HBsAg\u6e05\u9664\u7684\u53c2\u4e0e\u8005\u57fa\u7ebfHBsAg < 1500IU\/mL\u3002\u8054\u5408\u6cbb\u7597\u961f\u5217\u548cPEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u961f\u5217\u4e4b\u95f4\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u7684\u53d1\u751f\u7387\u76f8\u5f53\u3002\u5927\u591a\u6570TEAE\u4e0ePEG-IFN\u03b1\u7684\u5df2\u77e5\u526f\u4f5c\u7528\u4e00\u81f4\u3002<\/p>\n
\u4f5c\u4e3a\u817e\u76db\u535a\u836f\u5f00\u53d1HBV\u529f\u80fd\u6027\u6cbb\u6108\u7684\u72ec\u7279\u65b9\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u6211\u4eec\u5dee\u5f02\u5316\u4ea7\u54c1\u7ec4\u5408\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\uff0c\u5305\u62ecBRII-179\uff08\u6b63\u5728\u817e\u76db\u535a\u836f\u9886\u5bfc\u7684\u591a\u9879elebsiran\u8054\u5408\u7597\u6cd5<\/span>\u4e2d\u8fdb\u884c\u8bc4\u4f30<\/span>\uff09\uff1belebsiran\uff08\u6b63\u5728\u817e\u76db\u535a\u836f\u9886\u5bfc\u7684PEG-IFN\u03b1\u8054\u5408\u7597\u6cd5<\/span>\u4e2d\u8fdb\u884c\u8bc4\u4f30<\/span>\uff09\uff1b\u4ee5\u53catobevibart\uff08\u4e00\u79cd\u9776\u5411HBV\u7684\u7814\u7a76\u6027\u5e7f\u6cdb\u4e2d\u548c\u5355\u514b\u9686\u6297\u4f53\uff0c\u6b63\u5728Vir Biotechnology\u9886\u5bfc\u7684\u5728\u591a\u98792\u671f\u548c3\u671ftobevibart\u548celebsiran\u8054\u5408\u7597\u6cd5<\/span>\u4e2d\u8fdb\u884c\u8bc4\u4f30<\/span>\uff09\u3002\u6570\u6708\u540e\uff0c\u6211\u4eec\u5c06\u57282025\u5e74\u7684\u79d1\u5b66\u4f1a\u8bae\u4e0a\u5206\u4eab\u5173\u952e\u6570\u636e\u3002<\/p>\n\u5173\u4e8e\u4e59\u578b\u809d\u708e<\/p>\n
\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u80c1\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.54\u4ebf\u3002[1]\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7ea6\u670982\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027HBV\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u3002[1]\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u4eba\u6570\u8fbe8,700\u4e07\uff0c\u975e\u5e38\u503c\u5f97\u5173\u6ce8\u3002[2]<\/p>\n
\u5173\u4e8eBRII-179<\/p>\n
BRII-179\u662f\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u8d28\u7684\u65b0\u578bHBV \u514d\u75ab\u6cbb\u7597\u5019\u9009\u836f\u7269\uff0c\u53ef\u8868\u8fbeHBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8bf1\u5bfc\u589e\u5f3a\u548c\u5e7f\u6cdb\u7684B\u7ec6\u80de\u548cT\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u3002\u817e\u76db\u535a\u836f\u4e8e2018\u5e7412\u6708\u4eceVBI Vaccines, Inc.\uff08”VBI”\uff09\u5f15\u8fdb\u4e86BRII-179\uff0c\u8fd8\u81ea2023\u5e747\u6708\u8d77\uff0c\u5c06BRII-179\u7684\u72ec\u5bb6\u8bb8\u53ef\u6269\u5c55\u81f3\u5168\u7403\u5e02\u573a\u30022023\u5e7411\u6708\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u6cbb\u7597\u8ba4\u5b9a\u3002<\/p>\n
\u5173\u4e8eElebsiran\uff08\u66fe\u7528\u540dBRII-835\uff0cVIR-2218\uff09<\/p>\n
Elebsiran\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u836f\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f6c\u5f55\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u4ea7\u751f\uff0c\u5176\u5177\u6709\u9488\u5bf9HBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u91c7\u7528\u589e\u5f3a\u7a33\u5b9a\u5316\u5b66\u589e\u5f3a\u6280\u672f\u7684siRNA\uff0c\u4ee5\u589e\u5f3a\u7a33\u5b9a\u6027\u5e76\u6700\u5927\u7a0b\u5ea6\u5730\u51cf\u5c11\u8131\u9776\u6d3b\u6027\uff0c\u4ece\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7597\u6307\u6570\u3002\u817e\u76db\u535a\u836f\u4e8e2020\u5e74\u4eceVir Biotechnology, Inc. \u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316elebsiran\u7684\u72ec\u5bb6\u6743\u76ca\u3002<\/p>\n
\u5173\u4e8e\u817e\u76db\u535a\u836f<\/p>\n
\u817e\u76db\u535a\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6ee1\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7ed9\u60a3\u8005\u5e26\u6765\u4e25\u91cd\u793e\u4f1a\u6b67\u89c6\u7684\u91cd\u5927\u516c\u5171\u536b\u751f\u6311\u6218\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u3002\u516c\u53f8\u4e13\u6ce8\u4e8e\u611f\u67d3\u6027\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u8fdb\u4e00\u6761\u6db5\u76d6\u591a\u79cd\u72ec\u7279\u5019\u9009\u836f\u7269\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u91cd\u70b9\u5305\u62ec\u9488\u5bf9\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9886\u5148\u9879\u76ee\u3002\u5728\u5bcc\u6709\u8fdc\u89c1\u5353\u8bc6\u548c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u9886\u5bfc\u56e2\u961f\u5e26\u9886\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u4e8e\u7f57\u5229-\u8fbe\u52d2\u59c6\u3001\u65e7\u91d1\u5c71\u6e7e\u533a\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u672f\u4e2d\u5fc3\u5f00\u5c55\u4e1a\u52a1\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u00a0www.briibio.com\u3002<\/p>\n
\n
[1] World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/span><\/p>\n[2] World Health Organization. Hepatitis. World Health Organization. Retrieved from https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.<\/span><\/p>\n<\/div>\n\u00a0<\/p>\n
SOURCE \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"
ENSURE\u7814\u7a76\u961f\u52174\u7684\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u6570\u636e\u8868\u660e\uff0c\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u6709\u5e94\u7b54\u7684\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u6108\u6027\u6cbb\u7597\u540e\u76f8\u8f83BRII-179\u672a\u7ecf\u6cbb\u60a3\u8005\u5b9e\u73b0\u4e86\u66f4\u5feb\u3001\u66f4\u9ad8\u7684\u8868\u9762\u6297\u539f\u6e05\u9664\u7387\uff0c\u5f3a\u8c03\u4e86\u5229\u7528BRII-179\u8bc6\u522b\u548c\u514d\u75ab\u6fc0\u6d3b\u60a3\u8005\uff0c\u4ee5\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7ed3\u679c\u7684\u65b0\u578b\u5bcc\u96c6\u7b56\u7565ENSURE\u7814\u7a76\u961f\u52171-3\u768424\u5468\u968f\u8bbf\u7ed3\u679c\u8868\u660e\uff0c\u4e0ePEG-IFN\u03b1\u5355\u836f\u76f8\u6bd4\uff0celebsiran + PEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u5177\u6709\u6301\u7eed\u7684\u975e\u6cbb\u7597\u6027\u83b7\u76ca \u5317\u4eac\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62025\u5e745\u67088\u65e5 \/\u7f8e\u901a\u793e\/ — \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08”\u817e\u76db\u535a\u836f”\u6216”\u516c\u53f8”\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u5728\u8377\u5170\u963f\u59c6\u65af\u7279\u4e39\u4e3e\u884c\u76842025\u5e74\u6b27\u6d32\u809d\u75c5\u7814\u7a76\u534f\u4f1a\uff08EASL\uff09\u4f1a\u8bae\u4e0a\u4ee5\u6700\u65b0\u7a81\u7834\u58c1\u62a5\u7684\u5f62\u5f0f\u516c\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u6570\u636e\u3002 ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u60272\u671f\u7814\u7a76\u3002\u961f\u52171-3\u65e8\u5728\u8bc4\u4f30elebsiran\uff08\u4e00\u79cd\u7814\u7a76\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\uff09\u5728\u4e0e\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u8054\u5408\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\uff08\u57fa\u7ebf\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u4e3a100-3,000 IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002 \u961f\u52174\u5165\u7ec4\u4e86\u5728\u5148\u524d\u7684\u4e9a\u592a\u5730\u533a\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u8fc79\u5242BRII-179\uff08\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u8054\u5408elebsiran\u7ed9\u836f\u7684\u53c2\u4e0e\u8005\uff0c\u63a5\u53d7elebsiran\u4e0ePEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u3002\u8fd9\u4e9b\u53c2\u4e0e\u8005\u6839\u636e\u4ed6\u4eec\u4e4b\u524d\u63a5\u53d7 BRII-179 \u6cbb\u7597\u540e\u4ea7\u751f\u7684\u6297HBs\u5e94\u7b54\u8fdb\u884c\u5206\u7ec4\uff1a\u6297HBs\u6ef4\u5ea6\u5cf0\u503c \u2265 10 IU\/L\u7684\u53c2\u4e0e\u8005\u88ab\u5b9a\u4e49\u4e3a\u6297HBs\u5e94\u7b54\u8005\uff0c\u6297HBs\u6ef4\u5ea6\u5cf0\u503c < 10 IU\/L \u7684\u53c2\u4e0e\u8005\u88ab\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\u3002\u672c\u7814\u7a76\u961f\u5217 4 \u7684\u8bbe\u8ba1\u57fa\u4e8eBRII-179\u53ef\u4ee5\u533a\u5206\u514d\u75ab\u5e94\u7b54\u8005\u548c\u65e0\u5e94\u7b54\u8005\u7684\u4e00\u79cd\u89c1\u89e3\uff0c\u4ece\u800c\u4e3a\u9884\u6d4b\u672a\u6765\u7684\u6cbb\u7597\u5e94\u7b54\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002 \u961f\u52174\u7684\u4e2d\u671f\u6570\u636e\u663e\u793a\uff0c\u6297HBs\u5e94\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u663e\u8457\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\u3002EOT\uff08\u7b2c48\u5468\uff09\u65f6\uff0c61%\uff0811\/18\uff09\u7684\u6297HBs\u5e94\u7b54\u8005\u8fbe\u5230HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e3a10%\uff081\/10\uff09\u3002\u572811\u540d\u5b9e\u73b0HBsAg\u6e05\u9664\u7684\u6297HBs\u5e94\u7b54\u8005\u4e2d\uff0c91%\uff0810\/11\uff09\u5728EOT\u65f6\u7684\u6297HBs\u6ef4\u5ea6\u2265100 IU\/L\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c \u961f\u52174\u4e2d\u7684BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u6bd4\u961f\u52172\u548c\u961f\u52173\u4e2dBRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u66f4\u5feb\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u7b2c24\u5468\u65f6\u5728BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e2d\u5df2\u670983%\uff0810\/12\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u800cBRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e3a55% \uff086\/11\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5feb\u901f\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548c\u8f83\u9ad8\u7684\u6297HBs\u6ef4\u5ea6\u53ef\u8f6c\u5316\u4e3a\u6301\u4e45\u7684HBsAg\u6e05\u9664\uff0c\u4ee5\u53ca\u8bc4\u4f30\u7f29\u77edPEG-IFN\u03b1\u7597\u7a0b\u7684\u53ef\u80fd\u6027\u3002 ENSURE\u7814\u7a76\u961f\u52171-3\u7684\u5176\u4ed6\u6570\u636e\u8868\u660e\uff0c\u4e0ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c100\u6216200 \u6beb\u514belebsiran\u4e0ePEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u5728EOT24\u5468\u540e\u5747\u53ef\u5b9e\u73b0\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387\uff0c\u652f\u6301siRNA\u7684\u989d\u5916\u83b7\u76ca\u3002 \u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a”ENSURE\u7814\u7a76\u961f\u52174\u7684\u6570\u636e\u4ee4\u4eba\u9f13\u821e\u3002\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u53d1\u73b0\uff0c\u7ecf\u8fc7BRII-179\u9884\u6cbb\u7597\u4ea7\u751f\u514d\u75ab\u5e94\u7b54\u7684\u60a3\u8005\u5728\u5b9e\u73b0\u8f83\u9ad8\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u4f18\u52bf\u3002\u501f\u52a9BRII-179\uff0c\u6211\u4eec\u53ef\u4ee5\u8bc6\u522b\u5185\u5728\u514d\u75ab\u53d7\u635f\u7a0b\u5ea6\u8f83\u4f4e\u7684\u60a3\u8005\uff0c\u5e76\u8fdb\u4e00\u6b65\u589e\u5f3a\u5176\u514d\u75ab\u5e94\u7b54\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4f7f HBsAg \u6e05\u9664\u66f4\u6301\u4e45\uff0c\u5e76\u6709\u53ef\u80fd\u7f29\u77ed PEG-IFN\u03b1\u7684\u6cbb\u7597\u65f6\u95f4\u3002\u6211\u4eec\u6b63\u5728\u5168\u901f\u63a8\u8fdb\u4e34\u5e8a\u5de5\u4f5c\uff0c\u4ee5\u671f\u4e3a\u6162\u6027\u4e59\u578b\u809d\u708e\u60a3\u8005\u63d0\u4f9b\u6709\u610f\u4e49\u7684\u53ef\u9009\u65b9\u6848\u3002” \u6458\u8981\u7f16\u53f7\uff1aLB25123\/ LBP-018\u6807\u9898\uff1a\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u4ea7\u751f\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u53c2\u4e0e\u8005\u5728\u63a5\u53d7elebsiran \u548c PEG-IFN\u03b1 \u6cbb\u7597\u540e\u53ef\u83b7\u5f97\u66f4\u5feb\u66f4\u9ad8\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u6e05\u9664\u7387\uff1a\u6765\u81eaENSURE\u7814\u7a76\u7684\u6cbb\u7597\u7ed3\u675f\u65f6\u6570\u636e\u4e3b\u8bb2\u4eba\uff1a\u9ec4\u4e3d\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a \u5171\u5206\u6790\u4e8628\u4f8b\u57fa\u7ebfHBsAg > 100\u548c\u2264 3000 IU\/mL\u7684\u53c2\u4e0e\u8005\u3002\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\uff0cBRII-179\u8bf1\u5bfc\u768418\u4f8b\u53c2\u4e0e\u8005\u7684\u6297HBs\u6ef4\u5ea6\u5cf0\u503c\u2265 10 IU\/L\uff08\u5b9a\u4e49\u4e3a\u6297HBs\u5e94\u7b54\u8005\uff09\u548c10\u4f8b\u53c2\u4e0e\u8005< 10 IU\/L\uff08\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\uff09\u3002\u5728\u5f00\u59cbelebsiran + PEG-IFN\u03b1\u6cbb\u7597\u65f6\uff0c\u6297HBs\u5e94\u7b54\u8005\uff08539.4 [106.7-2165.0] IU\/mL\uff09\u7684HBsAg\u4e2d\u4f4d\u6570\uff08\u8303\u56f4\uff09\u5728\u6570\u503c\u4e0a\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\uff08219.3 [106.7-671.5] IU\/mL\uff09\u3002EOT\uff08\u7b2c48\u5468\uff09\u65f6\uff0c61%\uff0811\/18\uff09\u7684\u6297HBs\u5e94\u7b54\u8005\u8fbe\u5230HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e3a10%\uff081\/10\uff09\u3002\u5728HBsAg\u8f6c\u9634\u7684\u6297HBs\u5e94\u7b54\u8005\u4e2d\uff0c91%\uff0810\/11\uff09\u5728EOT\u65f6\u7684\u6297HBs\u6ef4\u5ea6\u2265100 […]<\/p>\n","protected":false},"author":0,"featured_media":10757,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-10756","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n
\u817e\u76db\u535a\u836f\u57282025\u5e74EASL\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u7684\u6700\u65b0\u7a81\u7834\u6570\u636e\uff0c\u8868\u660eBRII-179\u5728\u4fc3\u8fdb\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u65b9\u9762\u7684\u4f5c\u7528 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u817e\u76db\u535a\u836f\u57282025\u5e74easl\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u7684ensure-2\u671f\u7814\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u817e\u76db\u535a\u836f\u57282025\u5e74EASL\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u7684\u6700\u65b0\u7a81\u7834\u6570\u636e\uff0c\u8868\u660eBRII-179\u5728\u4fc3\u8fdb\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u65b9\u9762\u7684\u4f5c\u7528 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"ENSURE\u7814\u7a76\u961f\u52174\u7684\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u6570\u636e\u8868\u660e\uff0c\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u6709\u5e94\u7b54\u7684\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u6108\u6027\u6cbb\u7597\u540e\u76f8\u8f83BRII-179\u672a\u7ecf\u6cbb\u60a3\u8005\u5b9e\u73b0\u4e86\u66f4\u5feb\u3001\u66f4\u9ad8\u7684\u8868\u9762\u6297\u539f\u6e05\u9664\u7387\uff0c\u5f3a\u8c03\u4e86\u5229\u7528BRII-179\u8bc6\u522b\u548c\u514d\u75ab\u6fc0\u6d3b\u60a3\u8005\uff0c\u4ee5\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7ed3\u679c\u7684\u65b0\u578b\u5bcc\u96c6\u7b56\u7565ENSURE\u7814\u7a76\u961f\u52171-3\u768424\u5468\u968f\u8bbf\u7ed3\u679c\u8868\u660e\uff0c\u4e0ePEG-IFN\u03b1\u5355\u836f\u76f8\u6bd4\uff0celebsiran + PEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u5177\u6709\u6301\u7eed\u7684\u975e\u6cbb\u7597\u6027\u83b7\u76ca \u5317\u4eac\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62025\u5e745\u67088\u65e5 \/\u7f8e\u901a\u793e\/ — \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08”\u817e\u76db\u535a\u836f”\u6216”\u516c\u53f8”\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u5728\u8377\u5170\u963f\u59c6\u65af\u7279\u4e39\u4e3e\u884c\u76842025\u5e74\u6b27\u6d32\u809d\u75c5\u7814\u7a76\u534f\u4f1a\uff08EASL\uff09\u4f1a\u8bae\u4e0a\u4ee5\u6700\u65b0\u7a81\u7834\u58c1\u62a5\u7684\u5f62\u5f0f\u516c\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u6570\u636e\u3002 ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u60272\u671f\u7814\u7a76\u3002\u961f\u52171-3\u65e8\u5728\u8bc4\u4f30elebsiran\uff08\u4e00\u79cd\u7814\u7a76\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\uff09\u5728\u4e0e\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u8054\u5408\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\uff08\u57fa\u7ebf\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u4e3a100-3,000 IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002 \u961f\u52174\u5165\u7ec4\u4e86\u5728\u5148\u524d\u7684\u4e9a\u592a\u5730\u533a\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u8fc79\u5242BRII-179\uff08\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u8054\u5408elebsiran\u7ed9\u836f\u7684\u53c2\u4e0e\u8005\uff0c\u63a5\u53d7elebsiran\u4e0ePEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u3002\u8fd9\u4e9b\u53c2\u4e0e\u8005\u6839\u636e\u4ed6\u4eec\u4e4b\u524d\u63a5\u53d7 BRII-179 \u6cbb\u7597\u540e\u4ea7\u751f\u7684\u6297HBs\u5e94\u7b54\u8fdb\u884c\u5206\u7ec4\uff1a\u6297HBs\u6ef4\u5ea6\u5cf0\u503c \u2265 10 IU\/L\u7684\u53c2\u4e0e\u8005\u88ab\u5b9a\u4e49\u4e3a\u6297HBs\u5e94\u7b54\u8005\uff0c\u6297HBs\u6ef4\u5ea6\u5cf0\u503c < 10 IU\/L \u7684\u53c2\u4e0e\u8005\u88ab\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\u3002\u672c\u7814\u7a76\u961f\u5217 4 \u7684\u8bbe\u8ba1\u57fa\u4e8eBRII-179\u53ef\u4ee5\u533a\u5206\u514d\u75ab\u5e94\u7b54\u8005\u548c\u65e0\u5e94\u7b54\u8005\u7684\u4e00\u79cd\u89c1\u89e3\uff0c\u4ece\u800c\u4e3a\u9884\u6d4b\u672a\u6765\u7684\u6cbb\u7597\u5e94\u7b54\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002 \u961f\u52174\u7684\u4e2d\u671f\u6570\u636e\u663e\u793a\uff0c\u6297HBs\u5e94\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u663e\u8457\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\u3002EOT\uff08\u7b2c48\u5468\uff09\u65f6\uff0c61%\uff0811\/18\uff09\u7684\u6297HBs\u5e94\u7b54\u8005\u8fbe\u5230HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e3a10%\uff081\/10\uff09\u3002\u572811\u540d\u5b9e\u73b0HBsAg\u6e05\u9664\u7684\u6297HBs\u5e94\u7b54\u8005\u4e2d\uff0c91%\uff0810\/11\uff09\u5728EOT\u65f6\u7684\u6297HBs\u6ef4\u5ea6\u2265100 IU\/L\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c \u961f\u52174\u4e2d\u7684BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u6bd4\u961f\u52172\u548c\u961f\u52173\u4e2dBRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u66f4\u5feb\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u7b2c24\u5468\u65f6\u5728BRII-179\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e2d\u5df2\u670983%\uff0810\/12\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0HBsAg\u6e05\u9664\uff0c\u800cBRII-179\u672a\u7ecf\u6cbb\u53c2\u4e0e\u8005\u4e3a55% \uff086\/11\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5feb\u901f\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548c\u8f83\u9ad8\u7684\u6297HBs\u6ef4\u5ea6\u53ef\u8f6c\u5316\u4e3a\u6301\u4e45\u7684HBsAg\u6e05\u9664\uff0c\u4ee5\u53ca\u8bc4\u4f30\u7f29\u77edPEG-IFN\u03b1\u7597\u7a0b\u7684\u53ef\u80fd\u6027\u3002 ENSURE\u7814\u7a76\u961f\u52171-3\u7684\u5176\u4ed6\u6570\u636e\u8868\u660e\uff0c\u4e0ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c100\u6216200 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