{"id":11485,"date":"2025-05-23T00:00:00","date_gmt":"2025-05-23T00:00:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9a%e8%88%92%e7%91%9e%e5%9f%ba%e5%a5%a5%e4%bb%91%e8%b5%9b%e6%b3%a8%e5%b0%84%e6%b6%b2%ef%bc%88ct041%ef%bc%89%e7%9a%84%e6%91%98%e8%a6%81%e5%b7%b2%e5%85%ac%e5%b8%83\/"},"modified":"2025-05-23T00:00:00","modified_gmt":"2025-05-23T00:00:00","slug":"%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9a%e8%88%92%e7%91%9e%e5%9f%ba%e5%a5%a5%e4%bb%91%e8%b5%9b%e6%b3%a8%e5%b0%84%e6%b6%b2%ef%bc%88ct041%ef%bc%89%e7%9a%84%e6%91%98%e8%a6%81%e5%b7%b2%e5%85%ac%e5%b8%83","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9a%e8%88%92%e7%91%9e%e5%9f%ba%e5%a5%a5%e4%bb%91%e8%b5%9b%e6%b3%a8%e5%b0%84%e6%b6%b2%ef%bc%88ct041%ef%bc%89%e7%9a%84%e6%91%98%e8%a6%81%e5%b7%b2%e5%85%ac%e5%b8%83\/","title":{"rendered":"\u79d1\u6d4e\u836f\u4e1a\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08CT041\uff09\u7684\u6458\u8981\u5df2\u516c\u5e03\u4e8eASCO\u7f51\u7ad9"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2025\u5e745\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5ba3\u5e03\uff0c\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u4ea7\u54c1\u7f16\u53f7\uff1aCT041\uff0c\u4e00\u6b3e\u9776\u5411Claudin18.2\u86cb\u767d\u7684\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\u5019\u9009\u4ea7\u54c1\uff09\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u9488\u5bf9\u665a\u671f\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u764c\u7684\u786e\u8bc1\u6027II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-ST-01, NCT04581473\uff09\u7684\u7814\u7a76\u7ed3\u679c\u6458\u8981\u5df2\u4e8eASCO\u7f51\u7ad9\u516c\u5e03\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/1722549\/Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>\u7814\u7a76\u540d\u79f0<br \/>\u9776\u5411Claudin18.2 CAR-T\u7ec6\u80de\uff08\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff09\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u6cbb\u7597\u7528\u4e8e\u65e2\u5f80\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80c3\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u764c\u60a3\u8005\uff1a\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001II\u671f\u8bd5\u9a8c\uff08CT041-ST-01\uff09\u7684\u4e3b\u8981\u7ed3\u679c\u00a0Claudin18.2-specific CAR T cells (Satri-cel) versus treatment of physician&#8217;s choice (TPC) for previously treated advanced gastric or gastroesophageal junction cancer (G\/GEJC): Primary results from a randomized, open-label, phase II trial (CT041-ST-01)<\/p>\n<p>\u6458\u8981\u7f16\u53f7<br \/>4003<\/p>\n<p>\u4f1a\u8bae\u7c7b\u578b\u4e0e\u540d\u79f0<br \/>\u53e3\u5934\u6458\u8981\u4f1a\u8bae\u2014\u2014\u80c3\u80a0\u764c\u4e13\u9898\uff1a\u80c3\u98df\u7ba1\u764c\u3001\u80f0\u817a\u764c\u4e0e\u809d\u80c6\u764c\u00a0Oral Abstract Session \u2013 Gastrointestinal Cancer\u2014 Gastroesophageal, Pancreatic, and Hepatobiliary<\/p>\n<p>\u53e3\u5934\u62a5\u544a\u65e5\u671f\u53ca\u65f6\u95f4<br \/>\u7f8e\u56fd\u4e2d\u90e8\uff08\u590f\u4ee4\u65f6\uff095\u670831\u65e5\u00a0\u4e0b\u53483:00-6:00\uff0c\u5373\u5317\u4eac\u65f6\u95f4\u00a02025\u5e746\u67081\u65e5\u00a0\u51cc\u66684:00-7:00<\/p>\n<p>\u8fd9\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u6bd4\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u4e0e\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u5728Claudin18.2\u8868\u8fbe\u9633\u6027\u3001\u81f3\u5c11\u4e8c\u7ebf\u6cbb\u7597\u5931\u8d25\u665a\u671f\u80c3\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u764c\uff08G\/GEJC\uff09\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4ef7\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u6570\u636e\u622a\u6b62\u65e5\u671f\u4e3a2024\u5e7410\u670818\u65e5\u3002<\/p>\n<p>\u5165\u7ec4\u60a3\u8005\u4ee52:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u81f3\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u7ec4\uff08satri-cel\/CT041\u7ec4\uff09\u6216\u7814\u7a76\u8005\u9009\u62e9\u6cbb\u7597\u7ec4\uff08TPC\u7ec4\uff09\u3002\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u7ec4\u53d7\u8bd5\u8005\u5c06\u63a5\u53d7CT041\u8f93\u6ce8\uff08250\u00d7106 \/\u6b21\uff0c\u6700\u591a3\u6b21\u8f93\u6ce8\uff09\u3002TPC\u7ec4\u53d7\u8bd5\u8005\u5c06\u6839\u636e\u7814\u7a76\u8005\u8bc4\u4f30\uff0c\u63a5\u53d7\u4e00\u79cd\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09\u836f\u7269\uff08\u5305\u62ec\u963f\u5e15\u66ff\u5c3c\u3001\u7d2b\u6749\u9187\u3001\u591a\u897f\u4ed6\u8d5b\u3001\u4f0a\u7acb\u66ff\u5eb7\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff09\u3002TPC\u7ec4\u53d7\u8bd5\u8005\u5982\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u836f\u7269\u4e0d\u8010\u53d7\uff0c\u6839\u636e\u7814\u7a76\u8005\u5224\u65ad\u53ef\u63a5\u53d7\u540e\u7eed\u7684CT041\u6cbb\u7597\u3002<\/p>\n<p>\u4ece2022\u5e743\u670829\u65e5\u81f32024\u5e748\u670816\u65e5\uff0c\u5171\u6709156\u4f8b\u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3CT041\u7ec4\uff08n=104\uff09\u6216TPC\u7ec4\uff08n=52\uff09\u3002\u5176\u4e2d\uff0cTPC\u7ec4\u4e2d\u670920\u4f8b\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86\u540e\u7eed\u7684CT041\u6cbb\u7597\u3002\u6240\u6709\u53d7\u8bd5\u8005\u65e2\u5f80\u5747\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e8c\u7ebf\u6cbb\u7597\uff0cCT041\u7ec4\u548cTPC\u7ec4\u5206\u522b\u670926.9% vs 19.2%\u53d7\u8bd5\u8005\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e09\u7ebf\u6cbb\u7597\uff1bLauren\u5f25\u6f2b\u578b\/\u6df7\u5408\u578b\u6bd4\u4f8b71.2% vs 65.4%\uff1b\u8179\u819c\u8f6c\u79fb\u6bd4\u4f8b69.2% vs 59.6%\u3002<\/p>\n<p>\u5728ITT\u5373\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff1a\u57fa\u4e8eIRC\u8bc4\u4ef7\uff0cCT041\u8f83\u6807\u51c6\u6cbb\u7597\u53ef\u663e\u8457\u5ef6\u957fPFS\uff08mPFS 3.25\u4e2a\u6708\u00a0vs 1.77\u4e2a\u6708\uff1bHR 0.366\uff0c95% CI\uff1a0.241\uff0c0.557\uff1bp&lt;0.0001\uff09\uff0c\u8fbe\u5230\u672c\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\/\u6b7b\u4ea1\u98ce\u9669\u663e\u8457\u4e0b\u964d\u8fbe63%\u3002\u540c\u65f6OS\u663e\u793a\u51fa\u660e\u663e\u7684\u83b7\u76ca\u8d8b\u52bf\uff08mOS 7.92\u4e2a\u6708\u00a0vs 5.49\u4e2a\u6708\uff1bHR 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\/>\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u662f\u4e00\u6b3e\u6f5c\u5728\u5168\u7403\u540c\u7c7b\u9996\u521b\u7684\u3001\u9776\u5411Claudin18.2\u86cb\u767d\u7684\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\u5019\u9009\u4ea7\u54c1\uff0c\u7528\u4e8e\u6cbb\u7597Claudin18.2\u9633\u6027\u5b9e\u4f53\u7624\uff0c\u4e3b\u8981\u6cbb\u7597\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u817a\u764c\u53ca\u80f0\u817a\u764c\u3002\u5df2\u5f00\u5c55\u7684\u8bd5\u9a8c\u5305\u62ec\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-CG4006, NCT03874897\uff09\uff0c\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u9488\u5bf9\u665a\u671f\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u817a\u764c\u7684\u786e\u8bc1\u6027II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-ST-01, NCT04581473\uff09\uff0c\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u9488\u5bf9\u80f0\u817a\u764c\u8f85\u52a9\u6cbb\u7597\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-ST-05, NCT05911217\uff09\uff0c\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u7528\u4e8e\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u540e\u5de9\u56fa\u6cbb\u7597\u7684\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-CG4010\uff0cNCT06857786\uff09\u4ee5\u53ca\u5728\u5317\u7f8e\u5f00\u5c55\u7684\u9488\u5bf9\u665a\u671f\u80c3\u764c\u6216\u80f0\u817a\u764c\u76841b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-ST-02, NCT04404595\uff09\u30022025\u5e743\u6708\uff0c\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u83b7\u5f97\u4e86\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6388\u4e88\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd\u8ba4\u5b9a\uff0c\u62df\u5b9a\u9002\u5e94\u75c7\u4e3a\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e8c\u7ebf\u6cbb\u7597\u5931\u8d25\u7684Claudin18.2\u8868\u8fbe\u9633\u6027\u7684\u665a\u671f\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u817a\u764c\u30022022\u5e741\u6708\uff0c\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u88ab\u7f8e\u56fdFDA\u6388\u4e88&#8221;\u518d\u751f\u533b\u5b66\u5148\u8fdb\u7597\u6cd5&#8221;\uff08RMAT\uff09\u8ba4\u5b9a\u7528\u4e8e\u6cbb\u7597Claudin18.2\u9633\u6027\u7684\u665a\u671f\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u817a\u764c\u30022020\u5e749\u6708\uff0c\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u88ab\u7f8e\u56fdFDA\u6388\u4e88&#8221;\u5b64\u513f\u836f&#8221;\u8ba4\u5b9a\u7528\u4e8e\u6cbb\u7597\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u817a\u764c\u3002<\/p>\n<p>\u5173\u4e8e\u79d1\u6d4e\u836f\u4e1a<br \/>\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u4ee5\u6ee1\u8db3\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u8840\u6db2\u6076\u6027\u80bf\u7624\u3001\u5b9e\u4f53\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u516c\u53f8\u5f62\u6210\u4e86\u4ece\u9776\u70b9\u53d1\u73b0\u3001\u4e34\u5e8a\u524d\u7814\u7a76\u3001\u4ea7\u54c1\u4e34\u5e8a\u5f00\u53d1\u5230\u5546\u4e1a\u89c4\u6a21\u751f\u4ea7\u7684CAR-T\u7ec6\u80de\u7814\u7a76\u4e0e\u5f00\u53d1\u7684\u7aef\u5230\u7aef\u80fd\u529b\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u65b0\u6280\u672f\u4ee5\u53ca\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4ee5\u89e3\u51b3\u73b0\u6709CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u6311\u6218\uff0c\u6bd4\u5982\u63d0\u9ad8\u5b89\u5168\u6027\uff0c\u63d0\u9ad8\u5b9e\u4f53\u7624\u6cbb\u7597\u7684\u7597\u6548\u548c\u964d\u4f4e\u6cbb\u7597\u6210\u672c\u7b49\u3002\u79d1\u6d4e\u836f\u4e1a\u7684\u4f7f\u547d\u662f\u6210\u4e3a\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u57df\u7684\u9886\u5bfc\u8005\uff0c\u4e3a\u5168\u7403\u764c\u75c7\u53ca\u5176\u4ed6\u75be\u75c5\u7684\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u548c\u5dee\u5f02\u5316\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u4f7f\u764c\u75c7\u53ca\u5176\u4ed6\u75be\u75c5\u53ef\u6cbb\u6108\u3002<\/p>\n<p>\u524d\u77bb\u6027\u58f0\u660e<br \/>\u672c\u65b0\u95fb\u7a3f\u4e2d\u6240\u6709\u4e0d\u5c5e\u4e8e\u5386\u53f2\u4e8b\u5b9e\u6216\u4e0e\u5f53\u524d\u4e8b\u5b9e\u6216\u5f53\u524d\u6761\u4ef6\u65e0\u5173\u7684\u9648\u8ff0\u90fd\u662f\u524d\u77bb\u6027\u9648\u8ff0\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u8868\u8fbe\u4e86\u672c\u96c6\u56e2\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u5f53\u524d\u89c2\u70b9\u3001\u9884\u6d4b\u3001\u4fe1\u5ff5\u548c\u9884\u671f\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u662f\u57fa\u4e8e\u672c\u96c6\u56e2\u65e0\u6cd5\u63a7\u5236\u7684\u4e00\u4e9b\u5047\u8bbe\u548c\u56e0\u7d20\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u53d7\u5230\u91cd\u5927\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u4e8b\u4ef6\u6216\u7ed3\u679c\u53ef\u80fd\u4e0e\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\uff0c\u672c\u65b0\u95fb\u7a3f\u4e2d\u8ba8\u8bba\u7684\u524d\u77bb\u6027\u4e8b\u4ef6\u53ef\u80fd\u4e0d\u4f1a\u53d1\u751f\u3002\u8fd9\u4e9b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6211\u4eec\u6700\u8fd1\u7684\u5e74\u5ea6\u62a5\u544a\u548c\u4e2d\u671f\u62a5\u544a\u4ee5\u53ca\u5728\u6211\u4eec\u516c\u53f8\u7f51\u7ad9https:\/\/www.carsgen.com \u4e0a\u53d1\u5e03\u7684\u5176\u4ed6\u516c\u544a\u548c\u62a5\u544a\u4e2d\u300c\u4e3b\u8981\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u300d\u6807\u9898\u4e0b\u7684\u8be6\u7ec6\u5185\u5bb9\u3002\u5bf9\u4e8e\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u4efb\u4f55\u9884\u6d4b\u3001\u76ee\u6807\u3001\u4f30\u8ba1\u6216\u9884\u6d4b\u7684\u5b9e\u73b0\u6216\u5408\u7406\u6027\uff0c\u6211\u4eec\u4e0d\u4f5c\u4efb\u4f55\u9648\u8ff0\u6216\u4fdd\u8bc1\uff0c\u4e5f\u4e0d\u5e94\u4f9d\u8d56\u8fd9\u4e9b\u9884\u6d4b\u3002<\/p>\n<p>\u8054\u7cfb\u79d1\u6d4e\u836f\u4e1a<br \/>\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a href=\"https:\/\/www.carsgen.com\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.carsgen.com\/<\/a><\/p>\n<p>SOURCE  \u79d1\u6d4e\u836f\u4e1a\u63a7\u80a1\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772025\u5e745\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5ba3\u5e03\uff0c\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u4ea7\u54c1\u7f16\u53f7\uff1aCT041\uff0c\u4e00\u6b3e\u9776\u5411Claudin18.2\u86cb\u767d\u7684\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\u5019\u9009\u4ea7\u54c1\uff09\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u9488\u5bf9\u665a\u671f\u80c3\u764c\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u764c\u7684\u786e\u8bc1\u6027II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08CT041-ST-01, NCT04581473\uff09\u7684\u7814\u7a76\u7ed3\u679c\u6458\u8981\u5df2\u4e8eASCO\u7f51\u7ad9\u516c\u5e03\u3002 \u7814\u7a76\u540d\u79f0\u9776\u5411Claudin18.2 CAR-T\u7ec6\u80de\uff08\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff09\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u6cbb\u7597\u7528\u4e8e\u65e2\u5f80\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80c3\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u764c\u60a3\u8005\uff1a\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001II\u671f\u8bd5\u9a8c\uff08CT041-ST-01\uff09\u7684\u4e3b\u8981\u7ed3\u679c\u00a0Claudin18.2-specific CAR T cells (Satri-cel) versus treatment of physician&#8217;s choice (TPC) for previously treated advanced gastric or gastroesophageal junction cancer (G\/GEJC): Primary results from a randomized, open-label, phase II trial (CT041-ST-01) \u6458\u8981\u7f16\u53f74003 \u4f1a\u8bae\u7c7b\u578b\u4e0e\u540d\u79f0\u53e3\u5934\u6458\u8981\u4f1a\u8bae\u2014\u2014\u80c3\u80a0\u764c\u4e13\u9898\uff1a\u80c3\u98df\u7ba1\u764c\u3001\u80f0\u817a\u764c\u4e0e\u809d\u80c6\u764c\u00a0Oral Abstract Session \u2013 Gastrointestinal Cancer\u2014 Gastroesophageal, Pancreatic, and Hepatobiliary \u53e3\u5934\u62a5\u544a\u65e5\u671f\u53ca\u65f6\u95f4\u7f8e\u56fd\u4e2d\u90e8\uff08\u590f\u4ee4\u65f6\uff095\u670831\u65e5\u00a0\u4e0b\u53483:00-6:00\uff0c\u5373\u5317\u4eac\u65f6\u95f4\u00a02025\u5e746\u67081\u65e5\u00a0\u51cc\u66684:00-7:00 \u8fd9\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u6bd4\u8212\u745e\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u4e0e\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u5728Claudin18.2\u8868\u8fbe\u9633\u6027\u3001\u81f3\u5c11\u4e8c\u7ebf\u6cbb\u7597\u5931\u8d25\u665a\u671f\u80c3\/\u98df\u7ba1\u80c3\u7ed3\u5408\u90e8\u764c\uff08G\/GEJC\uff09\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4ef7\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u6570\u636e\u622a\u6b62\u65e5\u671f\u4e3a2024\u5e7410\u670818\u65e5\u3002 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