{"id":11556,"date":"2025-05-25T17:09:00","date_gmt":"2025-05-25T17:09:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/menarini%e5%9c%a8asco-2025%e5%b9%b4%e4%bc%9a%e5%85%ac%e5%b8%83%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae\/"},"modified":"2025-05-25T17:09:00","modified_gmt":"2025-05-25T17:09:00","slug":"menarini%e5%9c%a8asco-2025%e5%b9%b4%e4%bc%9a%e5%85%ac%e5%b8%83%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/menarini%e5%9c%a8asco-2025%e5%b9%b4%e4%bc%9a%e5%85%ac%e5%b8%83%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae\/","title":{"rendered":"Menarini\u5728ASCO 2025\u5e74\u4f1a\u516c\u5e03\u6700\u65b0\u6570\u636e"},"content":{"rendered":"<p>ELEVATE\u7814\u7a76\u4e2delacestrant\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u548c\u745e\u535a\u897f\u5c3c\u961f\u5217\u7684\u521d\u6b65\u7597\u6548\u5206\u6790\uff0c\u4ee5\u53caelacestrant\u4e0e\u5176\u4ed6\u9776\u5411\u7597\u6cd5\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u6700\u65b0\u5b89\u5168\u6027\u6570\u636e\u5c06\u88ab\u516c\u5e03\u3002\u8fd9\u4e9b\u6570\u636e\u7a81\u663e\u4e86elacestrant\u4f5c\u4e3a\u5185\u5206\u6ccc\u6cbb\u7597\u57fa\u7840\u836f\u7269\uff0c\u4e0e\u5404\u7c7b\u9776\u5411\u836f\u7269\u8054\u5408\u7528\u4e8eER+\/HER2- mBC\u60a3\u8005\u7684\u6f5c\u5728\u4f5c\u7528\u3002\u901a\u8fc7\u5e7f\u6cdb\u7814\u7a76\u5efa\u7acb\u7684elacestrant\u7a33\u5065\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u8be5\u836f\u7269\u5728mBC\u548c\u65e9\u671f\u4e73\u817a\u764c\u4e2d\u4f5c\u4e3a\u5355\u836f\u53ca\u8054\u5408\u6cbb\u7597\u7684\u6f5c\u5728\u4ef7\u503c\u3002<\/p>\n<p><span class=\"legendSpanClass\">\u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u7ebd\u7ea6<\/span><span class=\"legendSpanClass\">2025\u5e745\u670826\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u56fd\u9645\u9886\u5148\u5236\u836f\u4e0e\u8bca\u65ad\u516c\u53f8Menarini Group\uff08\u7b80\u79f0Menarini\uff09\u53ca\u5176\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc.\uff08\u7b80\u79f0Stemline\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u7a81\u7834\u6027\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff09\uff0c\u5c06\u516c\u5e031b\/2\u671fELEVATE\u7814\u7a76\u5728\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\u3001HER2\u9634\u6027\uff08HER2-\uff09\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\u4e2d\u7684\u6700\u65b0\u521d\u6b65\u7597\u6548\u4e0e\u5b89\u5168\u6027\u6570\u636e\u3002 ELEVATE\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u53e3\u670d\u836f\u7269\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4ee5\u514b\u670dER+\/HER2- mBC\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0d\u540c\u8010\u836f\u673a\u5236\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u9884\u540e\u3002 \u6b64\u5916\uff0c\u5176\u8fd8\u5c06\u516c\u5e03\u591a\u9879\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u8fdb\u5c55\uff0c\u63a2\u7d22elacestrant\u4f5c\u4e3a\u8d2f\u7a7f\u4e73\u817a\u764c\u5168\u7a0b\u6cbb\u7597\u7684\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u57fa\u7840\u836f\u7269\u7684\u6f5c\u5728\u4ef7\u503c\u3002 \u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e2025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u3002<\/p>\n<div><\/div>\n<p>ELEVATE\u7814\u7a76\u5305\u62ec\u516d\u79cd\u6cbb\u7597\u65b9\u6848\uff0c\u8bc4\u4f30elacestrant\u4e0eCDK4\/6\u6291\u5236\u5242\uff08\u5e15\u535a\u897f\u5c3c\u3001\u963f\u8d1d\u897f\u5c3c\u548c\u745e\u535a\u897f\u5c3c\uff09\u4ee5\u53ca\u4e0ePI3K\/AKT\/mTOR\u901a\u8def\u6291\u5236\u5242\uff08\u4f9d\u7ef4\u83ab\u53f8\u3001\u963f\u57f9\u5229\u53f8\u548c\u5361\u5e15\u585e\u66ff\u5c3c\uff09\u7684\u8054\u5408\u7528\u836f\u3002 \u5728ASCO 2025\u4e0a\u62a5\u544a\u7684ELEVATE\u7ed3\u679c\uff08\u6458\u89811070\/49\uff09\u6db5\u76d6\u66f4\u65b0\u7684\u7597\u6548\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u5c55\u793a\u4e86elacestrant\u8054\u5408\u745e\u535a\u897f\u5c3c\u548celacestrant\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u961f\u5217\u7684\u826f\u597d\u521d\u6b65\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u00a02\u671f\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u88ab\u786e\u5b9a\u4e3aelacestrant 345 mg\u8054\u5408\u745e\u535a\u897f\u5c3c400 mg\u3002 elacestrant 345 mg\u8054\u5408\u4f9d\u7ef4\u83ab\u53f87.5 mg\u7684RP2D\u5148\u524d\u5df2\u6709\u62a5\u544a\u3002\u00a0<\/p>\n<p>\u201c\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u5728\u4f9d\u7ef4\u83ab\u53f8\u548c\u745e\u535a\u897f\u5c3c\u5206\u522b\u4e0eelacestrant\u8054\u5408\u4f7f\u7528\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u4e86\u79ef\u6781\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u7ed3\u679c\u3002 \u8fd9\u4e9b\u53d1\u73b0\u4e0e\u53bb\u5e7412\u6708\u516c\u5e03\u7684\u540c\u4e00\u7814\u7a76\u4e2delacestrant\u8054\u5408\u963f\u8d1d\u897f\u5c3c\u961f\u5217\u7684\u6709\u524d\u666f\u6570\u636e\u4e00\u81f4\uff0c\u5728\u8be5\u6cbb\u7597\u80cc\u666f\u4e0b\u4e5f\u663e\u793a\u51fa\u826f\u597d\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u201d\u5e0c\u671b\u4e4b\u57ce\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u5973\u6027\u764c\u75c7\u9879\u76ee\u4e3b\u4efb\u3001\u4e73\u817a\u80bf\u7624\u79d1\u4e3b\u4efb\u3001\u533b\u5b66\u535a\u58ebHope S. Rugo\u8868\u793a\uff0c\u00a0 \u201c\u968f\u7740ELEVATE\u7814\u7a76\u4e2d\u5404\u961f\u5217\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6570\u636e\u548c\u5b89\u5168\u6027\u6570\u636e\u4e0d\u65ad\u6210\u719f\uff0celacestrant\u6709\u6f5c\u529b\u6210\u4e3a\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u4e2d\u7684\u5185\u5206\u6ccc\u6cbb\u7597\u57fa\u7840\u836f\u7269\uff0c\u8fd9\u4ee4\u6211\u4eec\u611f\u5230\u9f13\u821e\u3002\u201d\u00a0<\/p>\n<p>\u53e6\u5916\u62a5\u544a\u7684\u6570\u636e\uff08\u6458\u89811079\/58\uff09\u63d0\u4f9b\u4e86ELEVATE\u7814\u7a76\u56db\u4e2a\u961f\u5217\u7684\u6700\u65b01b\/2\u671f\u5b89\u5168\u6027\u7ed3\u679c\uff0c\u5305\u62ecelacestrant\u8054\u5408\u745e\u535a\u897f\u5c3c\u3001\u4f9d\u7ef4\u83ab\u53f8\u3001\u963f\u57f9\u5229\u53f8\u548c\u5361\u5e15\u585e\u66ff\u5c3c\u7684\u6cbb\u7597\u7ec4\u3002 \u8fd9\u4e9b\u6700\u65b0\u521d\u6b65\u7ed3\u679c\u8868\u660e\uff0c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5404\u9776\u5411\u836f\u7269\u8054\u5408\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5f81\u76f8\u7b26\u3002<\/p>\n<p>\u201c\u8fd9\u4e9b\u6570\u636e\u8fdb\u4e00\u6b65\u5370\u8bc1\u4e86elacestrant\u4f5c\u4e3aER+\/HER2-\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\u9886\u57df\u8054\u5408\u7528\u836f\u9009\u62e9\u7684\u91cd\u8981\u6f5c\u529b\u3002\u201dMenarini Group\u9996\u5e2d\u6267\u884c\u5b98Elcin Barker Ergun\u8868\u793a\uff0c \u201c\u6211\u4eec\u8fd8\u5728\u63a2\u7d22elacestrant\u5728\u5176\u4ed6\u60a3\u8005\u4eba\u7fa4\u4e2d\u7684\u6f5c\u529b\uff0c\u5305\u62ec\u6211\u4eec\u76ee\u524d\u6b63\u5728\u62db\u52df\u7684ELEGANT\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u5176\u5bf9\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u6f5c\u5728\u76ca\u5904\u3002\u201d<\/p>\n<p>\u6b64\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u5c06\u5728ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u5176\u4ed6\u6570\u636e\u3002 \u6709\u5173Menarini Stemline\u6458\u8981\u7684\u5b8c\u6574\u5217\u8868\uff0c\u8bf7\u53c2\u9605\u4e0b\u6587\u3002<\/p>\n<p>Menarini Stemline\u6458\u8981\uff1a<\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1aelacestrant\uff08Ela\uff09\u8054\u5408\u745e\u535a\u897f\u5c3c\uff08Ribo\uff09\u548c\u4f9d\u7ef4\u83ab\u53f8\uff08Eve\uff09\u6cbb\u7597ER+\/HER2-\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\uff08pts\uff09\uff1a\u6765\u81eaELEVATE <span class=\"xn-money\">1b<\/span>\/2\u671f\uff08Ph\uff09\u5f00\u653e\u6807\u7b7e\u4f1e\u5f0f\u7814\u7a76\u7684\u66f4\u65b0\u6570\u636e\u3002<br \/>\u6458\u8981\u7f16\u53f7\uff1a1070<br \/>\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/>\u5730\u70b9\uff1aPoster Bd 49<br \/>\u62a5\u544a\u4f5c\u8005\uff1a<span class=\"xn-person\">Hope S. Rugo<\/span><\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1aelacestrant\u8054\u5408\u6cbb\u7597ER+\/HER2-\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\uff1a\u6765\u81eaELEVATE <span class=\"xn-money\">1b<\/span>\/2\u671f\uff08Ph\uff09\u5f00\u653e\u6807\u7b7e\u4f1e\u5f0f\u7814\u7a76\u7684\u5b89\u5168\u6027\u66f4\u65b0\u3002<br \/>\u6458\u8981\u7f16\u53f7\uff1a1079<br \/>\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/>\u5730\u70b9\uff1aPoster Bd 58<br \/>\u62a5\u544a\u4f5c\u8005\uff1a<span class=\"xn-person\">Nancy Chan<\/span><\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1aADELA\uff1aelacestrant\uff08ELA\uff09\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\uff08EVE\uff09\u5bf9\u6bd4ELA\u8054\u5408\u5b89\u6170\u5242\uff08PBO\uff09\u6cbb\u7597ER+\/HER2-\u665a\u671f\u4e73\u817a\u764c\uff08aBC\uff09\u4f34ESR1\u7a81\u53d8\u4e14\u5bf9\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u8054\u5408CDK4\/6\u6291\u5236\u5242\u8fdb\u5c55\u60a3\u8005\u7684\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u968f\u673a3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<br \/>\u6458\u8981\u7f16\u53f7\uff1aTPS1129<br \/>\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/>\u5730\u70b9\uff1aPoster Bd <span class=\"xn-money\">103b<\/span><br \/>\u62a5\u544a\u4f5c\u8005\uff1a<span class=\"xn-person\">Antonio Llombart-Cussac<\/span><\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1aELCIN\uff1aelacestrant\u6cbb\u7597\u672a\u63a5\u53d7\u8fc7CDK4\/6\u6291\u5236\u5242\uff08CDK4\/6i\uff09\u6cbb\u7597\u7684\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\u3001HER2\u9634\u6027\uff08HER2-\uff09\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\uff1a\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u591a\u4e2d\u5fc32\u671f\u7814\u7a76\u3002<br \/>\u6458\u8981\u7f16\u53f7\uff1aTPS1127<br \/>\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/>\u5730\u70b9\uff1aPoster Bd <span class=\"xn-money\">102b<\/span><br \/>\u62a5\u544a\u4f5c\u8005\uff1aVirginia G. Kaklamani<\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1aELEGANT\uff1aelacestrant\u5bf9\u6bd4\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u7528\u4e8e\u6dcb\u5df4\u7ed3\u9633\u6027\u3001\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\u3001HER2\u9634\u6027\uff08HER2-\uff09\u3001\u9ad8\u590d\u53d1\u98ce\u9669\u65e9\u671f\u4e73\u817a\u764c\uff08eBC\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u968f\u673a\u5f00\u653e\u6807\u7b7e3\u671f\u7814\u7a76\u3002<br \/>\u6458\u8981\u7f16\u53f7\uff1aTPS619<br \/>\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/>\u5730\u70b9\uff1aPoster Bd 210a<br \/>\u62a5\u544a\u4f5c\u8005\uff1aAditya Bardia<\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1aEORTC-2129-BCG\uff1aelacestrant\u6cbb\u7597ctDNA\u590d\u53d1\u7684ER+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\uff08TREAT ctDNA\uff09<br \/>\u6458\u8981\u7f16\u53f7\uff1aTPS620<br \/>\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/>\u5730\u70b9\uff1aPoster Bd <span class=\"xn-money\">210b<\/span><br \/>\u62a5\u544a\u4f5c\u8005\uff1a<span class=\"xn-person\">Michail Ignatiadis<\/span><\/p>\n<p>\u5173\u4e8eelacestrant\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee<\/p>\n<p>\u76ee\u524d\u8fd8\u5728\u591a\u9879\u516c\u53f8\u8d44\u52a9\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7814\u7a76elacestrant\uff0c\u5305\u62ec\u5355\u72ec\u4f7f\u7528\u6216\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u3002 ELEVATE\uff08<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05563220\" target=\"_blank\" rel=\"noopener\">NCT05563220<\/a>\uff09\u662f\u4e00\u98791b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4e0e\u963f\u57f9\u5229\u53f8\u3001\u4f9d\u7ef4\u83ab\u53f8\u3001\u5361\u5e15\u585e\u66ff\u5c3c\u3001\u5e15\u535a\u897f\u5c3c\u3001\u745e\u535a\u897f\u5c3c\u6216\u963f\u8d1d\u897f\u5c3c\u8054\u5408\u7528\u836f\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002 ELECTRA\uff08<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05386108\" target=\"_blank\" rel=\"noopener\">NCT05386108<\/a>\uff09\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc31b\/2\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4e0e\u963f\u8d1d\u897f\u5c3c\u8054\u5408\u7528\u4e8eER+\u3001HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002 2\u671f\u90e8\u5206\u5c06\u8bc4\u4f30\u8fd9\u4e00\u6cbb\u7597\u65b9\u6848\u5728\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u7684\u6548\u679c\u3002 ELCIN\uff08<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05596409\" target=\"_blank\" rel=\"noopener\">NCT05596409<\/a>\uff09\u662f\u4e00\u98792\u671f\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u6216\u4e24\u79cd\u6fc0\u7d20\u6cbb\u7597\u4e14\u5728\u764c\u75c7\u8f6c\u79fb\u60c5\u51b5\u4e0b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7CDK4\/6\u6291\u5236\u5242\u6cbb\u7597\u7684ER+\u3001HER2-\u665a\u671f\/\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u7597\u6548\u3002 ADELA\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06382948?cond=Breast%20Cancer&amp;term=Elacestrant%20&amp;limit=25&amp;page=1&amp;rank=12\" target=\"_blank\" rel=\"noopener\">NCT06382948<\/a>\uff09\u662f\u4e00\u98793\u671f\u968f\u673a\u53cc\u76f2\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8eER+\u3001HER2- mBC\u4f34ESR1\u7a81\u53d8\u80bf\u7624\u60a3\u8005\u7684\u7597\u6548\u3002 \u7531\u7814\u7a76\u8005\u4e3b\u5bfc\u7684\u5176\u4ed6\u8bd5\u9a8c\u3001\u4e0e\u5176\u4ed6\u516c\u53f8\u5408\u4f5c\u5f00\u5c55\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u548c\u65e9\u671f\u75be\u75c5\u8bd5\u9a8c\u4e5f\u5728\u5bf9elacestrant\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p>\u5173\u4e8eORSERDU\uff08elacestrant\uff09<\/p>\n<p>\u7f8e\u56fd\u9002\u5e94\u75c7\uff1aORSERDU\uff08elacestrant\uff09345 mg\u7247\u5242\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u9634\u6027\u3001ESR1\u7a81\u53d8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7edd\u7ecf\u540e\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u60a3\u8005\uff0c\u4e14\u60a3\u8005\u9700\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002<\/p>\n<p>\u6709\u5173\u7f8e\u56fd\u7684\u5b8c\u6574\u5904\u65b9\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.orserdu.com\/\" target=\"_blank\" rel=\"noopener\">www.orserdu.com<\/a>\u3002<\/p>\n<p>\u91cd\u8981\u5b89\u5168\u6027\u4fe1\u606f<\/p>\n<p>\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879<\/p>\n<p class=\"prnml40\">\u8840\u8102\u5f02\u5e38\uff1a\u670d\u7528ORSERDU\u7684\u60a3\u8005\u4e2d\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a30%\u548c27%\u3002 3\u7ea7\u548c4\u7ea7\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a0.9%\u548c2.2%\u3002\u00a0 \u5728\u5f00\u59cb\u670d\u7528ORSERDU\u4e4b\u524d\u53ca\u670d\u7528\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u8102\u3002<\/p>\n<p class=\"prnml40\">\u80da\u80ce\u6bd2\u6027\uff1a\u6839\u636e\u52a8\u7269\u8bd5\u9a8c\u7ed3\u679c\u53ca\u5176\u4f5c\u7528\u673a\u5236\uff0cORSERDU\u7528\u4e8e\u5b55\u5987\u65f6\u53ef\u80fd\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\u3002\u00a0 \u5411\u5b55\u5987\u548c\u80b2\u9f84\u5973\u6027\u544a\u77e5\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u3002 \u5efa\u8bae\u80b2\u9f84\u5973\u6027\u5728\u4f7f\u7528ORSERDU\u8fdb\u884c\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002 \u5efa\u8bae\u6709\u80b2\u9f84\u5973\u6027\u4f34\u4fa3\u7684\u7537\u6027\u60a3\u8005\u5728\u4f7f\u7528ORSERDU\u8fdb\u884c\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<\/p>\n<p>\u4e0d\u826f\u53cd\u5e94<\/p>\n<p class=\"prnml40\">\u63a5\u53d7ORSERDU\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u670912%\u51fa\u73b0\u8fc7\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002 \u63a5\u53d7ORSERDU\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u53d1\u751f\u7387&gt;1%\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db\uff081.7%\uff09\u548c\u6076\u5fc3\uff081.3%\uff09\u3002 \u63a5\u53d7ORSERDU\u6cbb\u7597\u60a3\u8005\u4e2d\uff0c\u67091.7%\u51fa\u73b0\u8fc7\u81f4\u547d\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u5fc3\u810f\u9aa4\u505c\u3001\u611f\u67d3\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\uff08\u54041\u540d\u60a3\u8005\uff09\u3002 \u5305\u62ec\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u5f02\u5e38\u5728\u5185\uff0cORSERDU\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08&gt;10%\uff09\u4e3a\uff1a\u808c\u8089\u9aa8\u9abc\u75bc\u75db\uff0841%\uff09\u3001\u6076\u5fc3\uff0835%\uff09\u3001\u80c6\u56fa\u9187\u5347\u9ad8\uff0830%\uff09\u3001AST\u5347\u9ad8\uff0829%\uff09\u3001\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\uff0827%\uff09\u3001\u4e4f\u529b\uff0826%\uff09\u3001\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\uff0826%\uff09\u3001\u5455\u5410\uff0819%\uff09\u3001ALT\u5347\u9ad8\uff0817%\uff09\u3001\u8840\u94a0\u964d\u4f4e\uff0816%\uff09\u3001\u808c\u9150\u5347\u9ad8\uff0816%\uff09\u3001\u98df\u6b32\u51cf\u9000\uff0815%\uff09\u3001\u8179\u6cfb\uff0813%\uff09\u3001\u5934\u75db\uff0812%\uff09\u3001\u4fbf\u79d8\uff0812%\uff09\u3001\u8179\u75db\uff0811%\uff09\u3001\u6f6e\u70ed\uff0811%\uff09\u4ee5\u53ca\u6d88\u5316\u4e0d\u826f\uff0810%\uff09\u3002<\/p>\n<p>\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/p>\n<p class=\"prnml40\">\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u548c\/\u6216\u6291\u5236\u5242\u540c\u65f6\u4f7f\u7528\uff1a\u907f\u514d\u5f3a\u6548\u6216\u4e2d\u6548CYP3A4\u6291\u5236\u5242\u4e0eORSERDU\u540c\u65f6\u4f7f\u7528\u3002 \u907f\u514d\u5f3a\u6548\u6216\u4e2d\u6548CYP3A4\u8bf1\u5bfc\u5242\u4e0eORSERDU\u540c\u65f6\u4f7f\u7528\u3002<\/p>\n<p>\u7279\u6b8a\u4eba\u7fa4\u7528\u836f<\/p>\n<p class=\"prnml40\">\u54fa\u4e73\uff1a\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7ORSERDU\u6cbb\u7597\u671f\u95f4\u548c\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u4e0d\u8fdb\u884c\u6bcd\u4e73\u5582\u517b\u3002<br \/>\u809d\u529f\u80fd\u635f\u5bb3\uff1a\u907f\u514d\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\uff08Child-Pugh C\uff09\u60a3\u8005\u4f7f\u7528ORSERDU\u3002 \u5bf9\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\uff08Child-Pugh B\uff09\u60a3\u8005\u51cf\u5c11ORSERDU\u5242\u91cf\u3002<br \/>ORSERDU\u5bf9\u513f\u79d1\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u4e0d\u786e\u5b9a\u3002<\/p>\n<p>\u5982\u9700\u62a5\u544a\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\uff0c\u8bf7\u81f4\u75351-877-332-7961\u8054\u7cfbStemline Therapeutics, Inc.\uff0c\u4ea6\u53ef\u901a\u8fc71-800-FDA-1088\u6216<a href=\"http:\/\/www.fda.gov\/medwatch\" target=\"_blank\" rel=\"noopener\">www.fda.gov\/medwatch<\/a>\u8054\u7cfbFDA\u3002<\/p>\n<p>\u5173\u4e8eMenarini Group<\/p>\n<p>Menarini Group\u662f\u4e00\u5bb6\u56fd\u9645\u9886\u5148\u7684\u5236\u836f\u548c\u8bca\u65ad\u516c\u53f8\uff0c\u8425\u4e1a\u989d\u8fbe47\u4ebf\u7f8e\u5143\uff0c\u62e5\u670917,000\u591a\u540d\u5458\u5de5\u3002 Menarini\u4e13\u6ce8\u4e8e\u6ee1\u8db3\u9700\u6c42\u7f3a\u53e3\u5de8\u5927\u7684\u6cbb\u7597\u9886\u57df\uff0c\u5176\u4ea7\u54c1\u6db5\u76d6\u5fc3\u810f\u75c5\u5b66\u3001\u80bf\u7624\u5b66\u3001\u80ba\u75c5\u5b66\u3001\u80c3\u80a0\u75c5\u5b66\u3001\u4f20\u67d3\u75c5\u5b66\u3001\u7cd6\u5c3f\u75c5\u5b66\u3001\u708e\u75c7\u548c\u9547\u75db\u7b49\u9886\u57df\u3002 Menarini\u62e5\u670918\u4e2a\u751f\u4ea7\u57fa\u5730\u548c9\u4e2a\u7814\u53d1\u4e2d\u5fc3\uff0c\u4ea7\u54c1\u7545\u9500\u5168\u7403140\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.menarini.com&amp;esheet=53558844&amp;newsitemid=20230920907427&amp;lan=en-US&amp;anchor=www.menarini.com&amp;index=5&amp;md5=7682feaaefe280a649c9a9d8a9e54a2c\" target=\"_blank\" rel=\"noopener\">www.menarini.com<\/a>\u3002<\/p>\n<p>\u5173\u4e8eStemline Therapeutics Inc.<\/p>\n<p>Stemline Therapeutics, Inc.\uff08\u7b80\u79f0Stemline\uff09\u662fMenarini Group\u65d7\u4e0b\u7684\u5168\u8d44\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u4e3a\u60a3\u8005\u63d0\u4f9b\u53d8\u9769\u6027\u80bf\u7624\u6cbb\u7597\u65b9\u6848\u3002 \u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u5168\u7403\u5176\u4ed6\u5730\u533a\uff0cStemline\u5546\u4e1a\u5316\u63a8\u5e7f\u53e3\u670d\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269elacestrant\uff0c\u8be5\u836f\u9002\u7528\u4e8e\u6cbb\u7597\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u9634\u6027\u3001ESR1\u7a81\u53d8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff08\u7edd\u7ecf\u540e\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\uff09\uff0c\u4e14\u60a3\u8005\u9700\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002 Stemline\u540c\u65f6\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u5168\u7403\u5176\u4ed6\u5730\u533a\u5546\u4e1a\u5316\u63a8\u5e7f\u9776\u5411CD123\u7684\u521b\u65b0\u7597\u6cd5tagraxofusp-erzs\uff0c\u7528\u4e8e\u6cbb\u7597\u4fb5\u88ad\u6027\u8840\u6db2\u764c\u2014\u2014\u6bcd\u7ec6\u80de\u6027\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u7ec6\u80de\u80bf\u7624\uff08BPDCN\uff09\u3002 \u6b64\u5916\uff0cStemline\u5728\u6b27\u6d32\u5546\u4e1a\u5316\u63a8\u5e7fXPO1\u6291\u5236\u5242selinexor\uff0c\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6cbb\u7597\u3002 \u8be5\u516c\u53f8\u8fd8\u5728\u4e73\u817a\u764c\u548c\u8840\u6db2\u764c\u9002\u5e94\u75c7\u4e2d\u5206\u522b\u4f7f\u7528elacestrant\u548ctagraxofusp\u8fdb\u884c\u591a\u9879\u6807\u7b7e\u6269\u5c55\u7814\u7a76\uff0c\u5e76\u4e14\u62e5\u6709\u4f17\u591a\u5904\u4e8e\u4e0d\u540c\u5f00\u53d1\u9636\u6bb5\u4e14\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u548c\u8840\u6db2\u764c\u7684\u5176\u4ed6\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\u3002<\/p>\n<p>SOURCE  Menarini Industrie Farmaceutiche Riunite<\/p>","protected":false},"excerpt":{"rendered":"<p>ELEVATE\u7814\u7a76\u4e2delacestrant\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u548c\u745e\u535a\u897f\u5c3c\u961f\u5217\u7684\u521d\u6b65\u7597\u6548\u5206\u6790\uff0c\u4ee5\u53caelacestrant\u4e0e\u5176\u4ed6\u9776\u5411\u7597\u6cd5\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u6700\u65b0\u5b89\u5168\u6027\u6570\u636e\u5c06\u88ab\u516c\u5e03\u3002\u8fd9\u4e9b\u6570\u636e\u7a81\u663e\u4e86elacestrant\u4f5c\u4e3a\u5185\u5206\u6ccc\u6cbb\u7597\u57fa\u7840\u836f\u7269\uff0c\u4e0e\u5404\u7c7b\u9776\u5411\u836f\u7269\u8054\u5408\u7528\u4e8eER+\/HER2- mBC\u60a3\u8005\u7684\u6f5c\u5728\u4f5c\u7528\u3002\u901a\u8fc7\u5e7f\u6cdb\u7814\u7a76\u5efa\u7acb\u7684elacestrant\u7a33\u5065\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u8be5\u836f\u7269\u5728mBC\u548c\u65e9\u671f\u4e73\u817a\u764c\u4e2d\u4f5c\u4e3a\u5355\u836f\u53ca\u8054\u5408\u6cbb\u7597\u7684\u6f5c\u5728\u4ef7\u503c\u3002 \u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u7ebd\u7ea62025\u5e745\u670826\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u56fd\u9645\u9886\u5148\u5236\u836f\u4e0e\u8bca\u65ad\u516c\u53f8Menarini Group\uff08\u7b80\u79f0Menarini\uff09\u53ca\u5176\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc.\uff08\u7b80\u79f0Stemline\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u7a81\u7834\u6027\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff09\uff0c\u5c06\u516c\u5e031b\/2\u671fELEVATE\u7814\u7a76\u5728\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\u3001HER2\u9634\u6027\uff08HER2-\uff09\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\u4e2d\u7684\u6700\u65b0\u521d\u6b65\u7597\u6548\u4e0e\u5b89\u5168\u6027\u6570\u636e\u3002 ELEVATE\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u53e3\u670d\u836f\u7269\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4ee5\u514b\u670dER+\/HER2- mBC\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0d\u540c\u8010\u836f\u673a\u5236\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u9884\u540e\u3002 \u6b64\u5916\uff0c\u5176\u8fd8\u5c06\u516c\u5e03\u591a\u9879\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u8fdb\u5c55\uff0c\u63a2\u7d22elacestrant\u4f5c\u4e3a\u8d2f\u7a7f\u4e73\u817a\u764c\u5168\u7a0b\u6cbb\u7597\u7684\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u57fa\u7840\u836f\u7269\u7684\u6f5c\u5728\u4ef7\u503c\u3002 \u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e2025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u3002 ELEVATE\u7814\u7a76\u5305\u62ec\u516d\u79cd\u6cbb\u7597\u65b9\u6848\uff0c\u8bc4\u4f30elacestrant\u4e0eCDK4\/6\u6291\u5236\u5242\uff08\u5e15\u535a\u897f\u5c3c\u3001\u963f\u8d1d\u897f\u5c3c\u548c\u745e\u535a\u897f\u5c3c\uff09\u4ee5\u53ca\u4e0ePI3K\/AKT\/mTOR\u901a\u8def\u6291\u5236\u5242\uff08\u4f9d\u7ef4\u83ab\u53f8\u3001\u963f\u57f9\u5229\u53f8\u548c\u5361\u5e15\u585e\u66ff\u5c3c\uff09\u7684\u8054\u5408\u7528\u836f\u3002 \u5728ASCO 2025\u4e0a\u62a5\u544a\u7684ELEVATE\u7ed3\u679c\uff08\u6458\u89811070\/49\uff09\u6db5\u76d6\u66f4\u65b0\u7684\u7597\u6548\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u5c55\u793a\u4e86elacestrant\u8054\u5408\u745e\u535a\u897f\u5c3c\u548celacestrant\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u961f\u5217\u7684\u826f\u597d\u521d\u6b65\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u00a02\u671f\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u88ab\u786e\u5b9a\u4e3aelacestrant 345 mg\u8054\u5408\u745e\u535a\u897f\u5c3c400 mg\u3002 elacestrant 345 mg\u8054\u5408\u4f9d\u7ef4\u83ab\u53f87.5 mg\u7684RP2D\u5148\u524d\u5df2\u6709\u62a5\u544a\u3002\u00a0 \u201c\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u5728\u4f9d\u7ef4\u83ab\u53f8\u548c\u745e\u535a\u897f\u5c3c\u5206\u522b\u4e0eelacestrant\u8054\u5408\u4f7f\u7528\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u4e86\u79ef\u6781\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u7ed3\u679c\u3002 \u8fd9\u4e9b\u53d1\u73b0\u4e0e\u53bb\u5e7412\u6708\u516c\u5e03\u7684\u540c\u4e00\u7814\u7a76\u4e2delacestrant\u8054\u5408\u963f\u8d1d\u897f\u5c3c\u961f\u5217\u7684\u6709\u524d\u666f\u6570\u636e\u4e00\u81f4\uff0c\u5728\u8be5\u6cbb\u7597\u80cc\u666f\u4e0b\u4e5f\u663e\u793a\u51fa\u826f\u597d\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u201d\u5e0c\u671b\u4e4b\u57ce\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u5973\u6027\u764c\u75c7\u9879\u76ee\u4e3b\u4efb\u3001\u4e73\u817a\u80bf\u7624\u79d1\u4e3b\u4efb\u3001\u533b\u5b66\u535a\u58ebHope S. Rugo\u8868\u793a\uff0c\u00a0 \u201c\u968f\u7740ELEVATE\u7814\u7a76\u4e2d\u5404\u961f\u5217\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6570\u636e\u548c\u5b89\u5168\u6027\u6570\u636e\u4e0d\u65ad\u6210\u719f\uff0celacestrant\u6709\u6f5c\u529b\u6210\u4e3a\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u4e2d\u7684\u5185\u5206\u6ccc\u6cbb\u7597\u57fa\u7840\u836f\u7269\uff0c\u8fd9\u4ee4\u6211\u4eec\u611f\u5230\u9f13\u821e\u3002\u201d\u00a0 \u53e6\u5916\u62a5\u544a\u7684\u6570\u636e\uff08\u6458\u89811079\/58\uff09\u63d0\u4f9b\u4e86ELEVATE\u7814\u7a76\u56db\u4e2a\u961f\u5217\u7684\u6700\u65b01b\/2\u671f\u5b89\u5168\u6027\u7ed3\u679c\uff0c\u5305\u62ecelacestrant\u8054\u5408\u745e\u535a\u897f\u5c3c\u3001\u4f9d\u7ef4\u83ab\u53f8\u3001\u963f\u57f9\u5229\u53f8\u548c\u5361\u5e15\u585e\u66ff\u5c3c\u7684\u6cbb\u7597\u7ec4\u3002 \u8fd9\u4e9b\u6700\u65b0\u521d\u6b65\u7ed3\u679c\u8868\u660e\uff0c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5404\u9776\u5411\u836f\u7269\u8054\u5408\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5f81\u76f8\u7b26\u3002 \u201c\u8fd9\u4e9b\u6570\u636e\u8fdb\u4e00\u6b65\u5370\u8bc1\u4e86elacestrant\u4f5c\u4e3aER+\/HER2-\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\u9886\u57df\u8054\u5408\u7528\u836f\u9009\u62e9\u7684\u91cd\u8981\u6f5c\u529b\u3002\u201dMenarini Group\u9996\u5e2d\u6267\u884c\u5b98Elcin Barker Ergun\u8868\u793a\uff0c \u201c\u6211\u4eec\u8fd8\u5728\u63a2\u7d22elacestrant\u5728\u5176\u4ed6\u60a3\u8005\u4eba\u7fa4\u4e2d\u7684\u6f5c\u529b\uff0c\u5305\u62ec\u6211\u4eec\u76ee\u524d\u6b63\u5728\u62db\u52df\u7684ELEGANT\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u5176\u5bf9\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u6f5c\u5728\u76ca\u5904\u3002\u201d \u6b64\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u5c06\u5728ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u5176\u4ed6\u6570\u636e\u3002 \u6709\u5173Menarini Stemline\u6458\u8981\u7684\u5b8c\u6574\u5217\u8868\uff0c\u8bf7\u53c2\u9605\u4e0b\u6587\u3002 Menarini Stemline\u6458\u8981\uff1a \u62a5\u544a\u6807\u9898\uff1aelacestrant\uff08Ela\uff09\u8054\u5408\u745e\u535a\u897f\u5c3c\uff08Ribo\uff09\u548c\u4f9d\u7ef4\u83ab\u53f8\uff08Eve\uff09\u6cbb\u7597ER+\/HER2-\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\uff08pts\uff09\uff1a\u6765\u81eaELEVATE 1b\/2\u671f\uff08Ph\uff09\u5f00\u653e\u6807\u7b7e\u4f1e\u5f0f\u7814\u7a76\u7684\u66f4\u65b0\u6570\u636e\u3002\u6458\u8981\u7f16\u53f7\uff1a1070\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09\u5730\u70b9\uff1aPoster Bd 49\u62a5\u544a\u4f5c\u8005\uff1aHope S. Rugo \u62a5\u544a\u6807\u9898\uff1aelacestrant\u8054\u5408\u6cbb\u7597ER+\/HER2-\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\uff1a\u6765\u81eaELEVATE 1b\/2\u671f\uff08Ph\uff09\u5f00\u653e\u6807\u7b7e\u4f1e\u5f0f\u7814\u7a76\u7684\u5b89\u5168\u6027\u66f4\u65b0\u3002\u6458\u8981\u7f16\u53f7\uff1a1079\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09\u5730\u70b9\uff1aPoster Bd 58\u62a5\u544a\u4f5c\u8005\uff1aNancy Chan \u62a5\u544a\u6807\u9898\uff1aADELA\uff1aelacestrant\uff08ELA\uff09\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\uff08EVE\uff09\u5bf9\u6bd4ELA\u8054\u5408\u5b89\u6170\u5242\uff08PBO\uff09\u6cbb\u7597ER+\/HER2-\u665a\u671f\u4e73\u817a\u764c\uff08aBC\uff09\u4f34ESR1\u7a81\u53d8\u4e14\u5bf9\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u8054\u5408CDK4\/6\u6291\u5236\u5242\u8fdb\u5c55\u60a3\u8005\u7684\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u968f\u673a3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6458\u8981\u7f16\u53f7\uff1aTPS1129\u62a5\u544a\u65e5\u671f\u4e0e\u65f6\u95f4\uff1a6\u67082\u65e5\u661f\u671f\u4e00\u4e0a\u53489:00-\u4e2d\u534812:00\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09\u5730\u70b9\uff1aPoster Bd 103b\u62a5\u544a\u4f5c\u8005\uff1aAntonio Llombart-Cussac [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":11557,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-11556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Menarini\u5728ASCO 2025\u5e74\u4f1a\u516c\u5e03\u6700\u65b0\u6570\u636e - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/menarini\u5728asco-2025\u5e74\u4f1a\u516c\u5e03\u6700\u65b0\u6570\u636e\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Menarini\u5728ASCO 2025\u5e74\u4f1a\u516c\u5e03\u6700\u65b0\u6570\u636e - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"ELEVATE\u7814\u7a76\u4e2delacestrant\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u548c\u745e\u535a\u897f\u5c3c\u961f\u5217\u7684\u521d\u6b65\u7597\u6548\u5206\u6790\uff0c\u4ee5\u53caelacestrant\u4e0e\u5176\u4ed6\u9776\u5411\u7597\u6cd5\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u6700\u65b0\u5b89\u5168\u6027\u6570\u636e\u5c06\u88ab\u516c\u5e03\u3002\u8fd9\u4e9b\u6570\u636e\u7a81\u663e\u4e86elacestrant\u4f5c\u4e3a\u5185\u5206\u6ccc\u6cbb\u7597\u57fa\u7840\u836f\u7269\uff0c\u4e0e\u5404\u7c7b\u9776\u5411\u836f\u7269\u8054\u5408\u7528\u4e8eER+\/HER2- mBC\u60a3\u8005\u7684\u6f5c\u5728\u4f5c\u7528\u3002\u901a\u8fc7\u5e7f\u6cdb\u7814\u7a76\u5efa\u7acb\u7684elacestrant\u7a33\u5065\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u8be5\u836f\u7269\u5728mBC\u548c\u65e9\u671f\u4e73\u817a\u764c\u4e2d\u4f5c\u4e3a\u5355\u836f\u53ca\u8054\u5408\u6cbb\u7597\u7684\u6f5c\u5728\u4ef7\u503c\u3002 \u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u7ebd\u7ea62025\u5e745\u670826\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u56fd\u9645\u9886\u5148\u5236\u836f\u4e0e\u8bca\u65ad\u516c\u53f8Menarini Group\uff08\u7b80\u79f0Menarini\uff09\u53ca\u5176\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc.\uff08\u7b80\u79f0Stemline\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u7a81\u7834\u6027\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff09\uff0c\u5c06\u516c\u5e031b\/2\u671fELEVATE\u7814\u7a76\u5728\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\u3001HER2\u9634\u6027\uff08HER2-\uff09\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\u4e2d\u7684\u6700\u65b0\u521d\u6b65\u7597\u6548\u4e0e\u5b89\u5168\u6027\u6570\u636e\u3002 ELEVATE\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u53e3\u670d\u836f\u7269\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4ee5\u514b\u670dER+\/HER2- mBC\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0d\u540c\u8010\u836f\u673a\u5236\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u9884\u540e\u3002 \u6b64\u5916\uff0c\u5176\u8fd8\u5c06\u516c\u5e03\u591a\u9879\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u8fdb\u5c55\uff0c\u63a2\u7d22elacestrant\u4f5c\u4e3a\u8d2f\u7a7f\u4e73\u817a\u764c\u5168\u7a0b\u6cbb\u7597\u7684\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u57fa\u7840\u836f\u7269\u7684\u6f5c\u5728\u4ef7\u503c\u3002 \u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e2025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u3002 ELEVATE\u7814\u7a76\u5305\u62ec\u516d\u79cd\u6cbb\u7597\u65b9\u6848\uff0c\u8bc4\u4f30elacestrant\u4e0eCDK4\/6\u6291\u5236\u5242\uff08\u5e15\u535a\u897f\u5c3c\u3001\u963f\u8d1d\u897f\u5c3c\u548c\u745e\u535a\u897f\u5c3c\uff09\u4ee5\u53ca\u4e0ePI3K\/AKT\/mTOR\u901a\u8def\u6291\u5236\u5242\uff08\u4f9d\u7ef4\u83ab\u53f8\u3001\u963f\u57f9\u5229\u53f8\u548c\u5361\u5e15\u585e\u66ff\u5c3c\uff09\u7684\u8054\u5408\u7528\u836f\u3002 \u5728ASCO 2025\u4e0a\u62a5\u544a\u7684ELEVATE\u7ed3\u679c\uff08\u6458\u89811070\/49\uff09\u6db5\u76d6\u66f4\u65b0\u7684\u7597\u6548\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u5c55\u793a\u4e86elacestrant\u8054\u5408\u745e\u535a\u897f\u5c3c\u548celacestrant\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u961f\u5217\u7684\u826f\u597d\u521d\u6b65\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u00a02\u671f\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u88ab\u786e\u5b9a\u4e3aelacestrant 345 mg\u8054\u5408\u745e\u535a\u897f\u5c3c400 mg\u3002 elacestrant 345 mg\u8054\u5408\u4f9d\u7ef4\u83ab\u53f87.5 mg\u7684RP2D\u5148\u524d\u5df2\u6709\u62a5\u544a\u3002\u00a0 \u201c\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u5728\u4f9d\u7ef4\u83ab\u53f8\u548c\u745e\u535a\u897f\u5c3c\u5206\u522b\u4e0eelacestrant\u8054\u5408\u4f7f\u7528\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u4e86\u79ef\u6781\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u7ed3\u679c\u3002 \u8fd9\u4e9b\u53d1\u73b0\u4e0e\u53bb\u5e7412\u6708\u516c\u5e03\u7684\u540c\u4e00\u7814\u7a76\u4e2delacestrant\u8054\u5408\u963f\u8d1d\u897f\u5c3c\u961f\u5217\u7684\u6709\u524d\u666f\u6570\u636e\u4e00\u81f4\uff0c\u5728\u8be5\u6cbb\u7597\u80cc\u666f\u4e0b\u4e5f\u663e\u793a\u51fa\u826f\u597d\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u201d\u5e0c\u671b\u4e4b\u57ce\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u5973\u6027\u764c\u75c7\u9879\u76ee\u4e3b\u4efb\u3001\u4e73\u817a\u80bf\u7624\u79d1\u4e3b\u4efb\u3001\u533b\u5b66\u535a\u58ebHope S. 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