{"id":11868,"date":"2025-06-03T01:24:00","date_gmt":"2025-06-03T01:24:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/"},"modified":"2025-06-03T01:24:00","modified_gmt":"2025-06-03T01:24:00","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/","title":{"rendered":"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO"},"content":{"rendered":"

\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2025\u5e746\u67083\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aAAPG\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a6855\uff09\u5ba3\u5e03\uff0c\u00a0\u516c\u53f8\u5df2\u5728\u7b2c61\u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u53e3\u5934\u62a5\u544a\u4e86\u5728\u7814Bcl-2\u6291\u5236\u5242APG-2575\uff08lisaftoclax\uff09\u8054\u5408\u53bb\u7532\u57fa\u5316\u836f\u7269\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u6570\u636e\u3002<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u4f1a\u662f\u5168\u7403\u80bf\u7624\u9886\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u4e3a\u6743\u5a01\u7684\u5b66\u672f\u4ea4\u6d41\u76db\u4f1a\uff0c\u5c06\u5c55\u793a\u5f53\u524d\u56fd\u9645\u6700\u524d\u6cbf\u7684\u4e34\u5e8a\u80bf\u7624\u5b66\u79d1\u7814\u6210\u679c\u548c\u80bf\u7624\u6cbb\u7597\u6280\u672f\u3002\u4eca\u5e74\u662f\u4e9a\u76db\u533b\u836f\u8fde\u7eed\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u4f1a\uff0c\u6b64\u6b21\u516c\u53f8\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u70b9\u54c1\u79cdlisaftoclax\u548cMDM2-p53\u6291\u5236\u5242APG-115\uff08alrizomadlin\uff09\u5171\u6709\u4e24\u9879\u7814\u7a76\u5165\u9009\uff0c\u5176\u4e2d\u4e00\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002<\/p>\n

Lisaftoclax\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7814\u7a76\u4e3a\u4e00\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u7814\u7a76\uff0c\u622a\u81f32025\u5e744\u6708\uff0c\u5171\u5165\u7ec4103\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u65b0\u8bca\u65ad\u548c\u590d\u53d1\/\u96be\u6cbb\u7684AML\u548cMDS\u60a3\u8005\u3002\u8be5\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u9a8c\u8bc1\u4e86lisaftoclax\u5728\u6076\u6027\u9ad3\u7cfb\u80bf\u7624\u6cbb\u7597\u4e2d\u5353\u8d8a\u7597\u6548\u548c\u5353\u8d8a\u5b89\u5168\u6027\u4e8c\u8005\u517c\u5907\u7684\u7279\u70b9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u7814\u7a76\u9996\u6b21\u62a5\u544a\u4e86lisaftoclax\u5728\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u5f88\u597d\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u663e\u793a\u51falisaftoclax\u548c\u56fd\u5916\u540c\u7c7b\u4ea7\u54c1\u7684\u5dee\u5f02\u5316\u548c\u7597\u6548\u4f18\u52bf\u6f5c\u529b\u3002<\/p>\n

Lisaftoclax\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u5176\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u4e8e2024\u5e7411\u6708\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e8c\u4e2a\u9012\u4ea4NDA\u7684Bcl-2\u6291\u5236\u5242\u548c\u4e2d\u56fd\u9996\u4e2a\u9012\u4ea4NDA\u5e76\u8fdb\u5165\u4f18\u5148\u5ba1\u8bc4\u7684\u56fd\u4ea7\u539f\u7814Bcl-2\u6291\u5236\u5242\u3002\u76ee\u524d\uff0cLisaftoclax\u5171\u67094\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u51e0\u5927\u9002\u5e94\u75c7\uff0c\u4e14\u5176\u4e2d\u4e00\u9879\u4e3a\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8bb8\u53ef\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u3002<\/p>\n

\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09\u7684Patricia Kropf<\/span>\u6559\u6388\u8868\u793a\uff1a”\u672c\u7814\u7a76\u662f\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0clisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u521d\u6cbb\u4ee5\u53ca\u590d\u53d1\u96be\u6cbbAML\u3001MDS\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7597\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u6570\u636e\u4e3a\u5373\u5c06\u5f00\u5c55\u7684\u8be5\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u8fd9\u4e00\u60a3\u8005\u7fa4\u4f53\u7684III\u671f\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7279\u522b\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0clisaftoclax\u5728\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u514b\u670d\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u6f5c\u529b\uff0c\u8fd9\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u53d1\u73b0\uff0c\u8868\u660elisaftoclax\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u6211\u4eec\u671f\u5f85\u540e\u7eed\u66f4\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660elisaftoclax\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002”<\/p>\n

\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73b0\u51fa\u6cbb\u7597\u591a\u79cd\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u5f3a\u52b2\u6f5c\u529b\u3002\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u8fd9\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u522b\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0clisaftoclax\u5bf9\u4e8e\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u6709\u660e\u663e\u6cbb\u7597\u6f5c\u529b\uff0c\u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u62a5\u544a\u4e00\u79cdBcl-2\u6291\u5236\u5242\u514b\u670d\u53e6\u4e00\u79cdBcl-2\u6291\u5236\u5242\u8010\u836f\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u7740lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u6cbb\u7597\u9886\u57df\u5e26\u6765\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9002\u5e94\u75c7\u9886\u57df\uff0clisaftoclax\u5df2\u7ecf\u6709\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u3002\u6211\u4eec\u5c06\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002”<\/p>\n

\u5728\u6b64\u6b21ASCO\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u8be5\u4e34\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n

Phase 1b<\/span>\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients with Treatment-Na\u00efve or Prior Venetoclax-Exposed Myeloid Malignancies\u00a0
\u4e00\u9879\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\uff08AZA\uff09\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\uff08VEN\uff09\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\uff08Pts\uff09\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76<\/p>\n

\u6458\u8981\u7f16\u53f7\uff1a6505\u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a\u5206\u4f1a\u573a\u6807\u9898\uff1a\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u53ca\u540c\u79cd\u5f02\u4f53\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9a\u7687\u5bb6\u73c0\u65af\u533b\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9a\u963f\u5c14\u5f17\u96f7\u5fb7\u533b\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia Kropf\u535a\u58eb\u7b49\u6838\u5fc3\u8981\u70b9\uff1a
\u7814\u7a76\u80cc\u666f\uff1a
– AML\u548cMDS\u662f\u9884\u540e\u8f83\u5dee\u7684\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u3002
– \u53bb\u7532\u57fa\u5316\u836f\u7269\uff08HMAs\uff09AZA\u548c\u5730\u897f\u4ed6\u6ee8\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597MDS\u548cAML\uff0c\u5e76\u5df2\u8bc1\u660e\u53ef\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002\u7136\u800c\uff0c\u8fd8\u9700\u8981\u66f4\u591a\u7684\u6cbb\u7597\u65b9\u6848\u6765\u6539\u5584\u4e34\u5e8a\u7597\u6548\uff0c\u5982\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002
– Lisaftoclax\u662f\u4e00\u79cd\u5728\u7814\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5242\uff0c\u5df2\u5728\u4e34\u5e8a\u524d[1]\u548c\u4e34\u5e8a[2]\u7814\u7a76\u4e2d\u663e\u793a\u5176\u4e0e\u00a0AZA \u8054\u7528\u53ef\u589e\u5f3a\u5bf9\u00a0AML \u548c\u00a0MDS \u7684\u6cbb\u7597\u6548\u679c\u3002
\u7597\u6548\u6570\u636e\uff1a
– \u622a\u81f32025\u5e744\u6708\uff0c\u572828\u4f8b\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u590d\u53d1\/\u96be\u6cbb AML\/\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u60a3\u8005\u4e2d\uff0c\u7597\u6548\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u670922\u4f8b\uff0c\u603b\u53cd\u5e94\u7387\uff08ORR\uff09\u4e3a31.8%\uff087\/22\uff09\uff0c\u5176\u4e2d22.8%\u7684\u60a3\u8005CR\/ CR\u4f34\u8840\u7ec6\u80de\u672a\u5b8c\u5168\u6062\u590d\uff08Cri\uff09\uff1b4.6% \u7684\u60a3\u8005\u83b7\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff1b4.6%\u7684\u60a3\u8005\u83b7\u5f62\u6001\u5b66\u65e0\u767d\u8840\u75c5\u72b6\u6001\uff08MLFS\uff09\u3002\u83b7\u5f97\u6cbb\u7597\u53cd\u5e94\u7684\u60a3\u8005\u65e2\u5f80\u5747\u63a5\u53d7\u8fc7\u5305\u62ec\u7ef4\u5948\u514b\u62c9\u5728\u5185\u7684\u591a\u7ebf\u6cbb\u7597\uff0c\u4e14\u5927\u90e8\u5206\uff0871%\uff0c5\/7\uff09\u60a3\u8005\u57fa\u7ebf\u5b58\u5728TP53\u7a81\u53d8\u5e76\u4f34\u968f\u590d\u6742\u67d3\u8272\u4f53\u6838\u578b\u3002
– \u57286\u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u7684\u65b0\u8bca\u65ad\uff08ND\uff09AML\/ MPAL\u60a3\u8005\u4e2d\uff0cORR\u4e3a 83.3%, \u5176\u4e2d33.3%\u7684\u60a3\u8005\u83b7 CR\/CRi \uff0c50%\u7684\u60a3\u8005\u83b7PR\u3002\u5728 44 \u4f8b\u7597\u6548\u53ef\u8bc4\u4f30R\/R AML\/MPAL \u60a3\u8005\u4e2d\uff0cORR\u4e3a 43.2%\uff0c\u5176\u4e2d31.8% \u7684\u60a3\u8005\u83b7CR\/CRi \uff0c4.5%\u7684\u60a3\u8005\u83b7PR\uff0c6.8% \u7684\u60a3\u8005\u83b7MLFS\u3002
– \u572815\u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u7684 ND MDS\/\u6162\u6027\u7c92\u5355\u6838\u7ec6\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u60a3\u8005\u4e2d\uff0cORR\u4e3a 80%\uff0c\u5176\u4e2d40%\u7684\u60a3\u8005\u83b7CR\uff0c40%\u7684\u60a3\u8005\u83b7\u9aa8\u9ad3CR\uff08mCR\uff09\u300222 \u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u7684 R\/R MDS\/CMML \u60a3\u8005\u4e2d\uff0cORR\u4e3a 50%\uff0c\u5176\u4e2d27.3%\u7684\u60a3\u8005\u83b7 CR\uff0c18.2%\u7684\u60a3\u8005\u83b7 mCR\uff0c4.5%\u7684\u60a3\u8005\u83b7PR\u3002<\/p>\n

\u5b89\u5168\u6027\u6570\u636e\uff1aLisaftoclax\u8054\u5408AZA\u6cbb\u7597\uff0c\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u4f53\u73b0\u5728\u8840\u6db2\u5b66\u4e8b\u4ef6\uff0c\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u4e0d\u5e38\u89c1\u3002\u7edd\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u90fd\u53ef\u63a7\u5236\u3001\u53ef\u6062\u590d\u3001\u53ef\u8010\u53d7\u3002<\/p>\n

\u603b\u7ed3\uff1a\u00a0Lisaftoclax\u8054\u5408AZA\u6cbb\u7597TN\u6216\u590d\u53d1\/\u96be\u6cbb\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\uff0c\u5c55\u73b0\u51fa\u51fa\u8272\u7684\u4e34\u5e8a\u7597\u6548\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u7279\u522b\u662f\uff0clisaftoclax\u5c55\u793a\u51fa\u514b\u670d\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u6f5c\u529b\uff0c\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u62a5\u544a\u65b0\u578bBcl-2\u6291\u5236\u5242\u514b\u670d\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1]Zhai Y, Tang Q, Fang DD, et al. Lisaftoclax in Combination with Alrizomadlin Overcomes Venetoclax Resistance in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Preclinical Studies. Clin Cancer Res<\/span>. 2023;29:183-196. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0978<\/a>
[2]Wang H, Wei X, Jiang Q, et al. Safety and Efficacy of Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor (BCL-2i), in Relapsed or Refractory (R\/R) or Treatment-Na\u00efve (TN) Patients (Pts) with Acute Myeloid leukemia (AML), Myelodysplastic Syndrome (MDS), or Other Myeloid Neoplasms. Blood 2023;142(Suppl 1):2925. https:\/\/doi.org\/10.1182\/blood-2023-188489<\/a><\/p>\n

\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/p>\n

\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7efc\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u521b\u65b0\u836f\uff0c\u4ee5\u89e3\u51b3\u80bf\u7624\u7b49\u9886\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u56fd\u7eb3\u65af\u8fbe\u514b\u8bc1\u5238\u4ea4\u6613\u6240\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1aAAPG\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u5df2\u5efa\u7acb\u4e30\u5bcc\u7684\u521b\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\u3002<\/p>\n

\u516c\u53f8\u6838\u5fc3\u54c1\u79cd\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u4e14\u83b7\u6279\u9002\u5e94\u75c7\u5747\u88ab\u6210\u529f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff0c\u76ee\u524d\uff0c\u4e9a\u76db\u533b\u836f\u6b63\u5728\u5f00\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9879\u83b7\u7f8e\u56fdFDA\u8bb8\u53ef\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u8054\u5408\u6cbb\u7597\u65b0\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7597\u7425\u73c0\u9178\u8131\u6c22\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u7814\u7a76\u6b63\u5728\u5f00\u5c55\u4e2d\u3002<\/p>\n

\u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u79cd\uff0c\u65b0\u578bBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u83b7CDE\u53d7\u7406\uff0c\u5e76\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u76ee\u524d\uff0c\u4e9a\u76db\u533b\u836f\u6b63\u5728\u5f00\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9879\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5206\u522b\u4e3a\u83b7\u7f8e\u56fdFDA\u8bb8\u53ef\u7684\u6cbb\u7597\u7ecf\u6cbb\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7597\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u4e00\u7ebf\u6cbb\u7597\u65b0\u8bca\u65ad\u8001\u5e74\u6216\u4f53\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7597\u65b0\u8bca\u65ad\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518cIII\u671f\u7814\u7a76\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u4e2a\u5728\u7814\u65b0\u836f\u5171\u83b716\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0e\u6b66\u7530\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u3001\u4fe1\u8fbe\u7b49\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b66\u7b49\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u5df2\u5728\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u9886\u57df\u5efa\u7acb\u7ecf\u9a8c\u4e30\u5bcc\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u4e0e\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c”\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42”\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/p>\n

\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u7f8e\u56fd\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7ecf\u4fee\u8ba2\u7684\u300a1933\u5e74\u8bc1\u5238\u6cd5\u300b\u7b2c27A\u6761\u548c\u300a1934\u5e74\u8bc1\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u6761\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3002\u9664\u5386\u53f2\u4e8b\u5b9e\u9648\u8ff0\u5916\uff0c\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u5185\u5bb9\u5747\u53ef\u80fd\u6784\u6210\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u4e9a\u76db\u533b\u836f\u5bf9\u672a\u6765\u4e8b\u4ef6\u3001\u7ecf\u8425\u6210\u679c\u6216\u8d22\u52a1\u72b6\u51b5\u6240\u53d1\u8868\u7684\u610f\u89c1\u3001\u9884\u671f\u3001\u4fe1\u5ff5\u3001\u8ba1\u5212\u3001\u76ee\u6807\u3001\u5047\u8bbe\u6216\u9884\u6d4b\u3002<\/p>\n

\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\u53d7\u5230\u8bf8\u591a\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u7684\u5f71\u54cd\uff0c\u5177\u4f53\u5185\u5bb9\u5df2\u5728\u4e9a\u76db\u533b\u836f\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8be6\u7ec6\u8bf4\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7ecf\u4fee\u8ba2\u7684F-1\u8868\u683c\u6ce8\u518c\u8bf4\u660e\u4e66\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684”\u98ce\u9669\u56e0\u7d20”\u548c”\u5173\u4e8e\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u884c\u4e1a\u6570\u636e\u7684\u7279\u522b\u8bf4\u660e”\u7ae0\u8282\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u53d1\u884c\u4e0a\u5e02\u62db\u80a1\u4e66\u4e2d\u7684”\u524d\u77bb\u6027\u58f0\u660e”\u3001”\u98ce\u9669\u56e0\u7d20”\u7ae0\u8282\uff0c\u4ee5\u53ca\u6211\u4eec\u4e0d\u65f6\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u8fd9\u4e9b\u56e0\u7d20\u53ef\u80fd\u5bfc\u81f4\u5b9e\u9645\u4e1a\u7ee9\u3001\u8fd0\u8425\u6c34\u5e73\u3001\u7ecf\u8425\u6210\u679c\u6216\u6210\u5c31\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u5f02\u3002\u672c\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u7684\u9648\u8ff0\u4e0d\u6784\u6210\u516c\u53f8\u7ba1\u7406\u5c42\u7684\u5229\u6da6\u9884\u6d4b\u3002<\/p>\n

\u56e0\u6b64\uff0c\u8be5\u7b49\u524d\u77bb\u6027\u9648\u8ff0\u4e0d\u5e94\u88ab\u89c6\u4e3a\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u9884\u6d4b\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u57fa\u4e8e\u4e9a\u76db\u533b\u836f\u5f53\u524d\u5bf9\u672a\u6765\u53d1\u5c55\u53ca\u5176\u6f5c\u5728\u5f71\u54cd\u7684\u9884\u671f\u548c\u5224\u65ad\uff0c\u4e14\u4ec5\u4ee3\u8868\u622a\u81f3\u9648\u8ff0\u53d1\u8868\u4e4b\u65e5\u7684\u89c2\u70b9\u3002\u65e0\u8bba\u51fa\u73b0\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u4e9a\u76db\u533b\u836f\u5747\u65e0\u4e49\u52a1\u66f4\u65b0\u6216\u4fee\u8ba2\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u3002<\/p>\n

SOURCE \u4e9a\u76db\u533b\u836f<\/p>","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aAAPG\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a6855\uff09\u5ba3\u5e03\uff0c\u00a0\u516c\u53f8\u5df2\u5728\u7b2c61\u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u53e3\u5934\u62a5\u544a\u4e86\u5728\u7814Bcl-2\u6291\u5236\u5242APG-2575\uff08lisaftoclax\uff09\u8054\u5408\u53bb\u7532\u57fa\u5316\u836f\u7269\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u6570\u636e\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u4f1a\u662f\u5168\u7403\u80bf\u7624\u9886\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u4e3a\u6743\u5a01\u7684\u5b66\u672f\u4ea4\u6d41\u76db\u4f1a\uff0c\u5c06\u5c55\u793a\u5f53\u524d\u56fd\u9645\u6700\u524d\u6cbf\u7684\u4e34\u5e8a\u80bf\u7624\u5b66\u79d1\u7814\u6210\u679c\u548c\u80bf\u7624\u6cbb\u7597\u6280\u672f\u3002\u4eca\u5e74\u662f\u4e9a\u76db\u533b\u836f\u8fde\u7eed\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u4f1a\uff0c\u6b64\u6b21\u516c\u53f8\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u70b9\u54c1\u79cdlisaftoclax\u548cMDM2-p53\u6291\u5236\u5242APG-115\uff08alrizomadlin\uff09\u5171\u6709\u4e24\u9879\u7814\u7a76\u5165\u9009\uff0c\u5176\u4e2d\u4e00\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002 Lisaftoclax\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7814\u7a76\u4e3a\u4e00\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u7814\u7a76\uff0c\u622a\u81f32025\u5e744\u6708\uff0c\u5171\u5165\u7ec4103\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u65b0\u8bca\u65ad\u548c\u590d\u53d1\/\u96be\u6cbb\u7684AML\u548cMDS\u60a3\u8005\u3002\u8be5\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u9a8c\u8bc1\u4e86lisaftoclax\u5728\u6076\u6027\u9ad3\u7cfb\u80bf\u7624\u6cbb\u7597\u4e2d\u5353\u8d8a\u7597\u6548\u548c\u5353\u8d8a\u5b89\u5168\u6027\u4e8c\u8005\u517c\u5907\u7684\u7279\u70b9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u7814\u7a76\u9996\u6b21\u62a5\u544a\u4e86lisaftoclax\u5728\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u5f88\u597d\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u663e\u793a\u51falisaftoclax\u548c\u56fd\u5916\u540c\u7c7b\u4ea7\u54c1\u7684\u5dee\u5f02\u5316\u548c\u7597\u6548\u4f18\u52bf\u6f5c\u529b\u3002 Lisaftoclax\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u5176\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u4e8e2024\u5e7411\u6708\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e8c\u4e2a\u9012\u4ea4NDA\u7684Bcl-2\u6291\u5236\u5242\u548c\u4e2d\u56fd\u9996\u4e2a\u9012\u4ea4NDA\u5e76\u8fdb\u5165\u4f18\u5148\u5ba1\u8bc4\u7684\u56fd\u4ea7\u539f\u7814Bcl-2\u6291\u5236\u5242\u3002\u76ee\u524d\uff0cLisaftoclax\u5171\u67094\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u51e0\u5927\u9002\u5e94\u75c7\uff0c\u4e14\u5176\u4e2d\u4e00\u9879\u4e3a\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8bb8\u53ef\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u3002 \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09\u7684Patricia Kropf\u6559\u6388\u8868\u793a\uff1a”\u672c\u7814\u7a76\u662f\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0clisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u521d\u6cbb\u4ee5\u53ca\u590d\u53d1\u96be\u6cbbAML\u3001MDS\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7597\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u6570\u636e\u4e3a\u5373\u5c06\u5f00\u5c55\u7684\u8be5\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u8fd9\u4e00\u60a3\u8005\u7fa4\u4f53\u7684III\u671f\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7279\u522b\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0clisaftoclax\u5728\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u514b\u670d\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u6f5c\u529b\uff0c\u8fd9\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u53d1\u73b0\uff0c\u8868\u660elisaftoclax\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u6211\u4eec\u671f\u5f85\u540e\u7eed\u66f4\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660elisaftoclax\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002” \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73b0\u51fa\u6cbb\u7597\u591a\u79cd\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u5f3a\u52b2\u6f5c\u529b\u3002\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u8fd9\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u522b\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0clisaftoclax\u5bf9\u4e8e\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u6709\u660e\u663e\u6cbb\u7597\u6f5c\u529b\uff0c\u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u62a5\u544a\u4e00\u79cdBcl-2\u6291\u5236\u5242\u514b\u670d\u53e6\u4e00\u79cdBcl-2\u6291\u5236\u5242\u8010\u836f\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u7740lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u6cbb\u7597\u9886\u57df\u5e26\u6765\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9002\u5e94\u75c7\u9886\u57df\uff0clisaftoclax\u5df2\u7ecf\u6709\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u3002\u6211\u4eec\u5c06\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002” \u5728\u6b64\u6b21ASCO\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u8be5\u4e34\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients with Treatment-Na\u00efve or Prior Venetoclax-Exposed Myeloid Malignancies\u00a0\u4e00\u9879\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\uff08AZA\uff09\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\uff08VEN\uff09\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\uff08Pts\uff09\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76 \u6458\u8981\u7f16\u53f7\uff1a6505\u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a\u5206\u4f1a\u573a\u6807\u9898\uff1a\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u53ca\u540c\u79cd\u5f02\u4f53\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9a\u7687\u5bb6\u73c0\u65af\u533b\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9a\u963f\u5c14\u5f17\u96f7\u5fb7\u533b\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia […]<\/p>\n","protected":false},"author":0,"featured_media":11869,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-11868","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u4e9a\u76db\u533b\u836fbcl-2\u6291\u5236\u5242lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aAAPG\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a6855\uff09\u5ba3\u5e03\uff0c\u00a0\u516c\u53f8\u5df2\u5728\u7b2c61\u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u53e3\u5934\u62a5\u544a\u4e86\u5728\u7814Bcl-2\u6291\u5236\u5242APG-2575\uff08lisaftoclax\uff09\u8054\u5408\u53bb\u7532\u57fa\u5316\u836f\u7269\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u6570\u636e\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u4f1a\u662f\u5168\u7403\u80bf\u7624\u9886\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u4e3a\u6743\u5a01\u7684\u5b66\u672f\u4ea4\u6d41\u76db\u4f1a\uff0c\u5c06\u5c55\u793a\u5f53\u524d\u56fd\u9645\u6700\u524d\u6cbf\u7684\u4e34\u5e8a\u80bf\u7624\u5b66\u79d1\u7814\u6210\u679c\u548c\u80bf\u7624\u6cbb\u7597\u6280\u672f\u3002\u4eca\u5e74\u662f\u4e9a\u76db\u533b\u836f\u8fde\u7eed\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u4f1a\uff0c\u6b64\u6b21\u516c\u53f8\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u70b9\u54c1\u79cdlisaftoclax\u548cMDM2-p53\u6291\u5236\u5242APG-115\uff08alrizomadlin\uff09\u5171\u6709\u4e24\u9879\u7814\u7a76\u5165\u9009\uff0c\u5176\u4e2d\u4e00\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002 Lisaftoclax\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7814\u7a76\u4e3a\u4e00\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u7814\u7a76\uff0c\u622a\u81f32025\u5e744\u6708\uff0c\u5171\u5165\u7ec4103\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u65b0\u8bca\u65ad\u548c\u590d\u53d1\/\u96be\u6cbb\u7684AML\u548cMDS\u60a3\u8005\u3002\u8be5\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u9a8c\u8bc1\u4e86lisaftoclax\u5728\u6076\u6027\u9ad3\u7cfb\u80bf\u7624\u6cbb\u7597\u4e2d\u5353\u8d8a\u7597\u6548\u548c\u5353\u8d8a\u5b89\u5168\u6027\u4e8c\u8005\u517c\u5907\u7684\u7279\u70b9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u7814\u7a76\u9996\u6b21\u62a5\u544a\u4e86lisaftoclax\u5728\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u5f88\u597d\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u663e\u793a\u51falisaftoclax\u548c\u56fd\u5916\u540c\u7c7b\u4ea7\u54c1\u7684\u5dee\u5f02\u5316\u548c\u7597\u6548\u4f18\u52bf\u6f5c\u529b\u3002 Lisaftoclax\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u5176\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u4e8e2024\u5e7411\u6708\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e8c\u4e2a\u9012\u4ea4NDA\u7684Bcl-2\u6291\u5236\u5242\u548c\u4e2d\u56fd\u9996\u4e2a\u9012\u4ea4NDA\u5e76\u8fdb\u5165\u4f18\u5148\u5ba1\u8bc4\u7684\u56fd\u4ea7\u539f\u7814Bcl-2\u6291\u5236\u5242\u3002\u76ee\u524d\uff0cLisaftoclax\u5171\u67094\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u51e0\u5927\u9002\u5e94\u75c7\uff0c\u4e14\u5176\u4e2d\u4e00\u9879\u4e3a\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8bb8\u53ef\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u3002 \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09\u7684Patricia Kropf\u6559\u6388\u8868\u793a\uff1a”\u672c\u7814\u7a76\u662f\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0clisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u521d\u6cbb\u4ee5\u53ca\u590d\u53d1\u96be\u6cbbAML\u3001MDS\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7597\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u6570\u636e\u4e3a\u5373\u5c06\u5f00\u5c55\u7684\u8be5\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u8fd9\u4e00\u60a3\u8005\u7fa4\u4f53\u7684III\u671f\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7279\u522b\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0clisaftoclax\u5728\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u514b\u670d\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u6f5c\u529b\uff0c\u8fd9\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u53d1\u73b0\uff0c\u8868\u660elisaftoclax\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u6211\u4eec\u671f\u5f85\u540e\u7eed\u66f4\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660elisaftoclax\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002” \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73b0\u51fa\u6cbb\u7597\u591a\u79cd\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u5f3a\u52b2\u6f5c\u529b\u3002\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u8fd9\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u522b\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0clisaftoclax\u5bf9\u4e8e\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u6709\u660e\u663e\u6cbb\u7597\u6f5c\u529b\uff0c\u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u62a5\u544a\u4e00\u79cdBcl-2\u6291\u5236\u5242\u514b\u670d\u53e6\u4e00\u79cdBcl-2\u6291\u5236\u5242\u8010\u836f\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u7740lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u6cbb\u7597\u9886\u57df\u5e26\u6765\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9002\u5e94\u75c7\u9886\u57df\uff0clisaftoclax\u5df2\u7ecf\u6709\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u3002\u6211\u4eec\u5c06\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002” \u5728\u6b64\u6b21ASCO\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u8be5\u4e34\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients with Treatment-Na\u00efve or Prior Venetoclax-Exposed Myeloid Malignancies\u00a0\u4e00\u9879\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\uff08AZA\uff09\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\uff08VEN\uff09\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\uff08Pts\uff09\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76 \u6458\u8981\u7f16\u53f7\uff1a6505\u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a\u5206\u4f1a\u573a\u6807\u9898\uff1a\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u53ca\u540c\u79cd\u5f02\u4f53\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9a\u7687\u5bb6\u73c0\u65af\u533b\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9a\u963f\u5c14\u5f17\u96f7\u5fb7\u533b\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/moneycompass.com.my\/cn\/\u4e9a\u76db\u533b\u836fbcl-2\u6291\u5236\u5242lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\/\" \/>\n<meta property=\"og:site_name\" content=\"Money Compass CN\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-03T01:24:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"144\" \/>\n\t<meta property=\"og:image:height\" content=\"54\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/\",\"name\":\"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO - Money Compass CN\",\"isPartOf\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg\",\"datePublished\":\"2025-06-03T01:24:00+00:00\",\"dateModified\":\"2025-06-03T01:24:00+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#primaryimage\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg\",\"contentUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg\",\"width\":144,\"height\":54},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/moneycompass.com.my\/cn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/\",\"name\":\"Money Compass CN\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO - Money Compass CN","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/moneycompass.com.my\/cn\/\u4e9a\u76db\u533b\u836fbcl-2\u6291\u5236\u5242lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\/","og_locale":"en_US","og_type":"article","og_title":"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO - Money Compass CN","og_description":"\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aAAPG\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a6855\uff09\u5ba3\u5e03\uff0c\u00a0\u516c\u53f8\u5df2\u5728\u7b2c61\u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u53e3\u5934\u62a5\u544a\u4e86\u5728\u7814Bcl-2\u6291\u5236\u5242APG-2575\uff08lisaftoclax\uff09\u8054\u5408\u53bb\u7532\u57fa\u5316\u836f\u7269\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u6570\u636e\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u4f1a\u662f\u5168\u7403\u80bf\u7624\u9886\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u4e3a\u6743\u5a01\u7684\u5b66\u672f\u4ea4\u6d41\u76db\u4f1a\uff0c\u5c06\u5c55\u793a\u5f53\u524d\u56fd\u9645\u6700\u524d\u6cbf\u7684\u4e34\u5e8a\u80bf\u7624\u5b66\u79d1\u7814\u6210\u679c\u548c\u80bf\u7624\u6cbb\u7597\u6280\u672f\u3002\u4eca\u5e74\u662f\u4e9a\u76db\u533b\u836f\u8fde\u7eed\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u4f1a\uff0c\u6b64\u6b21\u516c\u53f8\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u70b9\u54c1\u79cdlisaftoclax\u548cMDM2-p53\u6291\u5236\u5242APG-115\uff08alrizomadlin\uff09\u5171\u6709\u4e24\u9879\u7814\u7a76\u5165\u9009\uff0c\u5176\u4e2d\u4e00\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002 Lisaftoclax\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7814\u7a76\u4e3a\u4e00\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u7814\u7a76\uff0c\u622a\u81f32025\u5e744\u6708\uff0c\u5171\u5165\u7ec4103\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u65b0\u8bca\u65ad\u548c\u590d\u53d1\/\u96be\u6cbb\u7684AML\u548cMDS\u60a3\u8005\u3002\u8be5\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u9a8c\u8bc1\u4e86lisaftoclax\u5728\u6076\u6027\u9ad3\u7cfb\u80bf\u7624\u6cbb\u7597\u4e2d\u5353\u8d8a\u7597\u6548\u548c\u5353\u8d8a\u5b89\u5168\u6027\u4e8c\u8005\u517c\u5907\u7684\u7279\u70b9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u7814\u7a76\u9996\u6b21\u62a5\u544a\u4e86lisaftoclax\u5728\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u5f88\u597d\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u663e\u793a\u51falisaftoclax\u548c\u56fd\u5916\u540c\u7c7b\u4ea7\u54c1\u7684\u5dee\u5f02\u5316\u548c\u7597\u6548\u4f18\u52bf\u6f5c\u529b\u3002 Lisaftoclax\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u5176\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u4e8e2024\u5e7411\u6708\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e8c\u4e2a\u9012\u4ea4NDA\u7684Bcl-2\u6291\u5236\u5242\u548c\u4e2d\u56fd\u9996\u4e2a\u9012\u4ea4NDA\u5e76\u8fdb\u5165\u4f18\u5148\u5ba1\u8bc4\u7684\u56fd\u4ea7\u539f\u7814Bcl-2\u6291\u5236\u5242\u3002\u76ee\u524d\uff0cLisaftoclax\u5171\u67094\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u51e0\u5927\u9002\u5e94\u75c7\uff0c\u4e14\u5176\u4e2d\u4e00\u9879\u4e3a\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8bb8\u53ef\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u3002 \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09\u7684Patricia Kropf\u6559\u6388\u8868\u793a\uff1a”\u672c\u7814\u7a76\u662f\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0clisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u521d\u6cbb\u4ee5\u53ca\u590d\u53d1\u96be\u6cbbAML\u3001MDS\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7597\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u6570\u636e\u4e3a\u5373\u5c06\u5f00\u5c55\u7684\u8be5\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u8fd9\u4e00\u60a3\u8005\u7fa4\u4f53\u7684III\u671f\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7279\u522b\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0clisaftoclax\u5728\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u51fa\u514b\u670d\u7ef4\u5948\u514b\u62c9\u8010\u836f\u7684\u6f5c\u529b\uff0c\u8fd9\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u53d1\u73b0\uff0c\u8868\u660elisaftoclax\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u6211\u4eec\u671f\u5f85\u540e\u7eed\u66f4\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660elisaftoclax\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002” \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73b0\u51fa\u6cbb\u7597\u591a\u79cd\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u5f3a\u52b2\u6f5c\u529b\u3002\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u8fd9\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u522b\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0clisaftoclax\u5bf9\u4e8e\u65e2\u5f80\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u6709\u660e\u663e\u6cbb\u7597\u6f5c\u529b\uff0c\u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u62a5\u544a\u4e00\u79cdBcl-2\u6291\u5236\u5242\u514b\u670d\u53e6\u4e00\u79cdBcl-2\u6291\u5236\u5242\u8010\u836f\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u7740lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u6cbb\u7597\u9886\u57df\u5e26\u6765\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9002\u5e94\u75c7\u9886\u57df\uff0clisaftoclax\u5df2\u7ecf\u6709\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u3002\u6211\u4eec\u5c06\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002” \u5728\u6b64\u6b21ASCO\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u8be5\u4e34\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients with Treatment-Na\u00efve or Prior Venetoclax-Exposed Myeloid Malignancies\u00a0\u4e00\u9879\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\uff08AZA\uff09\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\uff08VEN\uff09\u6cbb\u7597\u7684\u9ad3\u7cfb\u6076\u6027\u80bf\u7624\u60a3\u8005\uff08Pts\uff09\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76 \u6458\u8981\u7f16\u53f7\uff1a6505\u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a\u5206\u4f1a\u573a\u6807\u9898\uff1a\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u53ca\u540c\u79cd\u5f02\u4f53\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9a\u7687\u5bb6\u73c0\u65af\u533b\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9a\u963f\u5c14\u5f17\u96f7\u5fb7\u533b\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u56fdNovant Health\u533b\u7597\u96c6\u56e2\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia […]","og_url":"https:\/\/moneycompass.com.my\/cn\/\u4e9a\u76db\u533b\u836fbcl-2\u6291\u5236\u5242lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\/","og_site_name":"Money Compass CN","article_published_time":"2025-06-03T01:24:00+00:00","og_image":[{"width":144,"height":54,"url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/","url":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/","name":"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO - Money Compass CN","isPartOf":{"@id":"https:\/\/moneycompass.com.my\/cn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#primaryimage"},"image":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#primaryimage"},"thumbnailUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg","datePublished":"2025-06-03T01:24:00+00:00","dateModified":"2025-06-03T01:24:00+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#primaryimage","url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg","contentUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/06\/Ascentage_APAC_Logo-R7CrWn.jpeg","width":144,"height":54},{"@type":"BreadcrumbList","@id":"https:\/\/moneycompass.com.my\/cn\/%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82lisaftoclax%e9%92%88%e5%af%b9%e7%bb%b4%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%96%97%e5%a4%b1%e8%b4%a5%e6%82%a3%e8%80%85%e5%8f%a3\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/moneycompass.com.my\/cn\/"},{"@type":"ListItem","position":2,"name":"\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242Lisaftoclax\u9488\u5bf9\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u53e3\u5934\u62a5\u544a\u6570\u636e\u5f3a\u52b2\uff0c\u5168\u7403\u7ade\u4e89\u4f18\u52bf\u660e\u663e|\u76f4\u51fb2025 ASCO"}]},{"@type":"WebSite","@id":"https:\/\/moneycompass.com.my\/cn\/#website","url":"https:\/\/moneycompass.com.my\/cn\/","name":"Money Compass CN","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/11868"}],"collection":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/comments?post=11868"}],"version-history":[{"count":0,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/11868\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media\/11869"}],"wp:attachment":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media?parent=11868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/categories?post=11868"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/tags?post=11868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}