{"id":11926,"date":"2025-06-04T02:00:00","date_gmt":"2025-06-04T02:00:00","guid":{"rendered":"http:\/\/moneycompass.com.my\/cn\/%e6%80%bb-orr-87-5%ef%bc%9a%e8%bf%88%e5%a8%81%e7%94%9f%e7%89%a9-9mw2821-2025-asco-%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8a%e5%9b%9e%e9%a1%be\/"},"modified":"2025-06-04T02:00:00","modified_gmt":"2025-06-04T02:00:00","slug":"%e6%80%bb-orr-87-5%ef%bc%9a%e8%bf%88%e5%a8%81%e7%94%9f%e7%89%a9-9mw2821-2025-asco-%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8a%e5%9b%9e%e9%a1%be","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e6%80%bb-orr-87-5%ef%bc%9a%e8%bf%88%e5%a8%81%e7%94%9f%e7%89%a9-9mw2821-2025-asco-%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8a%e5%9b%9e%e9%a1%be\/","title":{"rendered":"\u603b ORR 87.5%\uff1a\u8fc8\u5a01\u751f\u7269 9MW2821 2025 ASCO \u53e3\u5934\u62a5\u544a\u56de\u987e"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2025\u5e746\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 5 \u6708 30 \u65e5 – 6 \u6708 3 \u65e5\u5728\u7f8e\u56fd\u829d\u52a0\u54e5\u4e3e\u529e\u7684 2025 \u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO\uff09\u4e0a\uff0c9MW2821 \u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff08la\/mUc\uff09\u60a3\u8005\u7684 Ib\/II \u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u7531\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6ccc\u5c3f\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u76db\u9521\u6960\u6559\u6388\u4ee3\u8868\u7814\u7a76\u56e2\u961f\u8fdb\u884c\u4e86\u62a5\u544a\u30029MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u5c55\u73b0\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u53e3\u5934\u62a5\u544a<\/p>\n

\u7814\u7a76\u80cc\u666f\uff1a<\/p>\n

\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u662f\u4e16\u754c\u8303\u56f4\u5185\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u30022024 \u5e74\u53d1\u5e03\u7684\u5168\u7403\u764c\u75c7\u7edf\u8ba1\u62a5\u544a\u4e2d\u663e\u793a\uff0c\u8180\u80f1\u764c\u662f\u5168\u7403\u7b2c\u4e5d\u5927\u5e38\u89c1\u8bca\u65ad\u7684\u764c\u75c7\uff0c\u6bcf\u5e74\u6709\u65b0\u53d1\u75c5\u4f8b\u7ea6 61.4 \u4e07\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7ea6 22.0 \u4e07\u3002\u7537\u6027\u75be\u75c5\u8d1f\u62c5\u548c\u53d1\u75c5\u7387\u663e\u8457\u9ad8\u4e8e\u5973\u6027\uff0c\u8180\u80f1\u764c\u662f\u7537\u6027\u7b2c\u516d\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u662f\u7537\u6027\u764c\u75c7\u6b7b\u4ea1\u7b2c\u4e5d\u5927\u539f\u56e0[1]\u3002<\/p>\n

9MW2821 (Bulumtatug Fuvedotin, BFv) \u662f\u65b0\u4e00\u4ee3\u9776\u5411 Nectin-4 \u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff0c\u65e9\u671f\u7814\u7a76\u663e\u793a 9MW2821 \u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u4eba\u7fa4\u4e2d\u5c55\u73b0\u4e86\u5177\u6709\u6f5c\u529b\u7684\u7597\u6548[2]\u3002\u5355\u836f\u672b\u7ebf\u7684 III \u671f\u5173\u952e\u4e34\u5e8a\u6b63\u5728\u8fdb\u884c\u4e2d\uff08NCT06196736\uff0cCTR20234024\uff09\u3002<\/p>\n

\u7279\u745e\u666e\u5229\u5355\u6297\uff08Toripalimab\uff09\u662f\u4e00\u79cd\u65b0\u578b\u4eba\u6e90\u5316\u91cd\u7ec4\u6297 PD-1 \u5355\u6297\uff0c\u5df2\u5148\u540e\u5728\u4e2d\u7f8e\u7b49\u591a\u56fd\u83b7\u6279\u4e0a\u5e02\u3002<\/p>\n

\u672c\u6b21 ASCO \u4f1a\u8bae\u9996\u6b21\u8be6\u7ec6\u6c47\u62a5\u4e86 9MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u7814\u7a76\u65b9\u6cd5\uff1a<\/p>\n

\u672c\u7814\u7a76\u662f\u4e00\u9879\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684\u00a0Ib\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7b5b\u9009\u5408\u683c\u7684\u53d7\u8bd5\u8005\u5c06\u63a5\u53d7 9MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u91c7\u7528\u56fa\u5b9a\u7ed9\u836f\u5242\u91cf 240mg\uff0c\u5728\u5242\u91cf\u9012\u589e\u9636\u6bb5 9MW2821 \u4ece 1.0mg\/kg \u9012\u589e\u81f31.25mg\/kg\uff0c\u5728\u961f\u5217\u6269\u5c55\u9636\u6bb5\u5c06\u5206\u522b\u5728 1.0mg\/kg \u548c 1.25mg\/kg \u5242\u91cf\u7ec4\u8fdb\u884c\u6269\u5c55\u3002\u6bcf 21 \u5929 1 \u4e2a\u5468\u671f\uff0c9MW2821 \u6bcf\u5468\u671f D1 \u548c D8 \u5404\u7ed9\u836f\u4e00\u6b21\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6bcf\u5468\u671f D1 \u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u7814\u7a76\u7ed3\u679c\uff1a<\/p>\n

\u622a\u81f3\u00a02025 \u5e74 4 \u6708 30 \u65e5\uff0c\u672c\u7814\u7a76\u5171\u5165\u7ec4 52 \u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff08la\/mUC\uff09\u53d7\u8bd5\u8005\u300240 \u4f8b\u53ef\u80bf\u8bc4\u7684\u665a\u671f UC \u4e00\u7ebf\u53d7\u8bd5\u8005\u4e2d\uff0c\u4e2d\u4f4d\u5e74\u9f84 67 \u5c81\uff0c70% \u4e3a\u7537\u6027\uff0c72.5% \u00a0ECOG \u8bc4\u5206\u4e3a 1 \u5206\uff0c\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\u4e3a\u4e0a\u5c3f\u8def\u7684\u5360\u6bd4 55%\uff0c\u809d\u8f6c\u79fb\u5360\u6bd4 15%\u3002\u751f\u7269\u6807\u5fd7\u7269\u8868\u8fbe\u65b9\u9762\uff0c82.5% \u4e3a Nectin-4 \u8868\u8fbe\u9633\u6027\uff0c20% \u4e3a PD-L1 \u8868\u8fbe\u9633\u6027\u3002<\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a 87.5%\uff0895% CI: 73.2\uff0c95.8\uff09\uff0c\u7ecf\u786e\u8ba4\u7684 ORR \u4e3a 80%\uff0cCR \u7387\u4e3a 12.5%\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a92.5%\uff0895% CI: 79.6\uff0c98.4\uff09\u3002\u6700\u4f73\u9776\u75c5\u7076\u5927\u5c0f\u53d8\u5316\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff0c97.5% \u7684\u53d7\u8bd5\u8005\u80bf\u7624\u75c5\u7076\u7f29\u5c0f\uff0c57.5% \u7684\u53d7\u8bd5\u8005\u80bf\u7624\u7f29\u5c0f\u8d85\u8fc7 50%\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

ORR \u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c\u5728\u9009\u5b9a\u7684\u4e9a\u7ec4\u4e2d\uff0cORR \u83b7\u76ca\u4e0e\u603b\u4f53\u4eba\u7fa4\u4fdd\u6301\u4e00\u81f4\u3002\u65e0\u8bba\u5e74\u9f84\u3001\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\u3001\u662f\u5426\u57fa\u7ebf\u5b58\u5728\u809d\u8f6c\u79fb\u3001\u4ee5\u53ca\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269 Nectin-4 \u548c PD-L1 \u7684\u8868\u8fbe\u72b6\u6001\uff0c\u6240\u6709\u4e9a\u7ec4\u5747\u53ef\u4ece 9MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u5e74\u9f84\u8d85\u8fc7 65 \u5c81\u3001\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\u4e3a\u4e0b\u5c3f\u8def\u3001\u809d\u8f6c\u79fb\u3001Nectin-4 \u8868\u8fbe\u9634\u6027\u4ee5\u53ca PD-L1 \u8868\u8fbe\u9633\u6027\u7684\u53d7\u8bd5\u8005 ORR \u5206\u522b\u4e3a100%\uff0824\/24\uff09\u300194.44%\uff0817\/18\uff09\u300183.33%\uff085\/6\uff09\u3001100%\uff087\/7\uff09\u3001100%\uff088\/8\uff09\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u622a\u81f3\u00a02025 \u5e74 4 \u6708 30 \u65e5\uff0c45%\u00a0(18\/40)\u00a0\u53d7\u8bd5\u8005\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a 12.5 \u4e2a\u6708\uff0895% CI\uff1a6.47-NA\uff09\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDoR\uff09\u5c1a\u672a\u8fbe\u5230\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a 10.8 \u4e2a\u6708\uff0cmPFS \u00a0\u548c mDoR \u5c1a\u672a\u6210\u719f\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u5b89\u5168\u6027\u65b9\u9762\uff0c\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u53d1\u751f\u7387\u4e3a 98.1%\uff0c\u7edd\u5927\u591a\u6570 TRAE \u4e3a 1-2 \u7ea7\uff1b3\u7ea7\u53ca\u4ee5\u4e0aTRAE \u53d1\u751f\u7387\u4e3a 42.3%\uff0c\u22653 \u7ea7\u7684 TRAE \u4e3b\u8981\u8868\u73b0\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0811.5%\uff09\u3001ALT \u5347\u9ad8\uff085.8%\uff09\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff085.8%\uff09\u7b49\uff1b\u6cbb\u7597\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u4e3a 28.8%\uff0c\u672a\u53d1\u751f\u5bfc\u81f4\u6b7b\u4ea1\u7684 TRAE\u3002\u8054\u5408\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u53d7\u8bd5\u8005\u6574\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u7ed3\u8bba\uff1a<\/p>\n

9MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u5c55\u73b0\u51fa\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u7814\u7a76\u4e2d\u9ad8\u9f84\u3001\u809d\u8f6c\u79fb\u4ee5\u53ca\u751f\u7269\u6807\u5fd7\u7269 Nectin-4 \u8868\u8fbe\u4e3a\u9634\u6027\u7684\u53d7\u8bd5\u8005\u4e5f\u5747\u53d6\u5f97\u4e86\u76f8\u5f53\u53ef\u89c2\u7684\u7597\u6548\u7f13\u89e3\uff0c\u9884\u793a\u7740\u76f8\u8f83\u4e8e\u4f20\u7edf\u542b\u94c2\u5316\u7597\uff0c9MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u5c06\u4e3a\u90a3\u4e9b\u4e0d\u80fd\u8010\u53d7\u542b\u94c2\u5316\u7597\u6216\u6f5c\u5728\u5316\u7597\u9884\u540e\u5dee\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6709\u671b\u6210\u4e3a\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u3001\u53ef\u8986\u76d6\u5168\u90e8\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u4eba\u7fa4\u7684\u65b0\u7597\u6cd5\u30029MW2821 \u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u5bf9\u6bd4\u542b\u94c2\u5316\u7597\u6cbb\u7597\u4e00\u7ebf\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u7684 III \u671f\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\uff08NCT06592326\uff0cCTR20242828\uff09\u3002<\/p>\n

\u5173\u4e8e\u00a09MW2821<\/p>\n

9MW2821 \u662f\u7531\u8fc8\u5a01\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411 Nectin-4 ADC \u521b\u65b0\u836f\uff0c\u901a\u8fc7\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5076\u8054\u6280\u672f\u8fde\u63a5\u5b50\u53ca\u4f18\u5316\u7684 ADC \u5076\u8054\u5de5\u827a\uff0c\u5b9e\u73b0\u6297\u4f53\u7684\u5b9a\u70b9\u4fee\u9970\u3002\u8be5\u54c1\u79cd\u662f\u56fd\u5185\u540c\u9776\u70b9\u836f\u7269\u4e2d\u9996\u4e2a\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u7684\u54c1\u79cd\uff0c\u4ea6\u662f\u5168\u7403\u540c\u9776\u70b9\u836f\u7269\u4e2d\u9996\u4e2a\u5728\u5bab\u9888\u764c\u3001\u98df\u7ba1\u764c\u4ee5\u53ca\u4e73\u817a\u764c\u9002\u5e94\u75c7\u62ab\u9732\u4e34\u5e8a\u6709\u6548\u6027\u6570\u636e\u7684\u54c1\u79cd\u3002\u76ee\u524d\u5df2\u5f00\u5c55\u4e09\u9879 III \u671f\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u3002\u5c3f\u8def\u4e0a\u76ae\u764c\u5355\u836f\u3001\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u5747\u88ab CDE \u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u540d\u5355\u3002\u5e76\u5df2\u88ab FDA \u6388\u4e88 3 \u9879\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff08FTD\uff09\u548c 1 \u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff08ODD\uff09\u3002<\/p>\n

[1] Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024;<\/p>\n

[2] Zhang et al. ASCO 2024.<\/p>\n

\u5173\u4e8e\u8fc8\u5a01\u751f\u7269<\/p>\n

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Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u603b-orr-87-5\uff1a\u8fc8\u5a01\u751f\u7269-9mw2821-2025-asco-\u53e3\u5934\u62a5\u544a\u56de\u987e\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u603b ORR 87.5%\uff1a\u8fc8\u5a01\u751f\u7269 9MW2821 2025 ASCO \u53e3\u5934\u62a5\u544a\u56de\u987e - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d772025\u5e746\u67084\u65e5 \/\u7f8e\u901a\u793e\/ — 5 \u6708 30 \u65e5 – 6 \u6708 3 \u65e5\u5728\u7f8e\u56fd\u829d\u52a0\u54e5\u4e3e\u529e\u7684 2025 \u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO\uff09\u4e0a\uff0c9MW2821 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