{"id":13995,"date":"2025-07-23T07:33:00","date_gmt":"2025-07-23T07:33:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/"},"modified":"2025-07-23T07:33:00","modified_gmt":"2025-07-23T07:33:00","slug":"%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/","title":{"rendered":"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2025\u5e747\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4ece\u53f8\u7f8e\u683c\u9c81\u80bd\u6380\u8d77\u7684&#8221;\u51cf\u80a5\u836f\u98ce\u66b4&#8221;\u5230MK-0616\u7684\u4e09\u73af\u80bd\u7a81\u7834\uff0c\u591a\u80bd\u836f\u7269\u6b63\u5728\u91cd\u65b0\u5b9a\u4e49\u751f\u7269\u533b\u836f\u7684\u8fb9\u754c\u3002\u5f53\u4e00\u4e2a60\u591a\u4e2a\u6c28\u57fa\u9178\u7684\u5206\u5b50\u53ef\u4ee5\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\uff0c\u5f53AI\u7b97\u6cd5\u80fd\u591f\u7cbe\u51c6\u9884\u6d4b\u6210\u73af\u7b56\u7565\u7684\u53ef\u884c\u6027&#8230;&#8230;\u8fd9\u4e0d\u4ec5\u4ec5\u662f\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u66f4\u662f\u4e00\u573a\u5173\u4e8e\u672a\u6765\u836f\u7269\u8bbe\u8ba1\u7684\u53d8\u5c40\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p><a href=\"https:\/\/mma.prnewswire.com\/media\/2735793\/image_5016940_33517010.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<\/div>\n<p>\u7ef4\u4e9a\u751f\u7269\u4f5c\u4e3a\u8fd9\u573a\u53d8\u5c40\u7684\u89c1\u8bc1\u8005\u548c\u63a8\u52a8\u8005\uff0c\u63d0\u4f9b\u4ece\u591a\u80bd\u7b5b\u9009\u5230PCC\u7684\u4e00\u4f53\u5316\u7814\u53d1\u670d\u52a1\u3002\u5728\u6700\u65b0\u63a8\u51fa\u7684\u7ef4\u4e9a\u533b\u836f\u89c2\u7cfb\u5217\u4e4b\u300a\u6df1\u5ea6\u5bf9\u8bdd\u4e28\u591a\u80bd\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u8def\u5f84\u63a2\u6790\u300b\u76f4\u64ad\u4e2d\uff0c<span>\u7ef4\u4e9a<\/span>\u5256\u6790\u4e86\u591a\u4e2a\u7a81\u7834\u6027\u6848\u4f8b\u80cc\u540e\u7684\u6280\u672f\u5bc6\u7801\uff0c\u5e76\u7ed3\u5408\u81ea\u8eab\u6210\u529f\u5b9e\u8df5\uff0c\u4e3a\u4e1a\u754c\u540c\u4ec1\u63d0\u4f9b\u72ec\u5bb6\u7684\u521b\u65b0\u89c6\u89d2\u3002\u9519\u8fc7\u672c\u671f\u76f4\u64ad\u7684\u670b\u53cb\uff0c\u53ef\u4ee5\u5173\u6ce8\u7ef4\u4e9a\u751f\u7269\u300c\u89c6\u9891\u53f7\u300d\u89c2\u770b\u7cbe\u5f69\u56de\u653e\u3002<\/p>\n<p>\u957f\u6548\u5316\u3001\u591a\u9776\u70b9\u8bbe\u8ba1\u7684\u65b0\u8d8b\u52bf<\/p>\n<p>\u591a\u80bd\u836f\u7269\u6b63\u671d\u7740\u957f\u6548\u5316\u548c\u591a\u9776\u70b9\u65b9\u5411\u53d1\u5c55\uff0c\u8fd9\u4e00\u8d8b\u52bf\u5728\u6700\u65b0\u7684\u7814\u53d1\u4e2d\u8868\u73b0\u5f97\u5c24\u4e3a\u660e\u663e\u3002\u867d\u7136\u53f8\u7f8e\u683c\u9c81\u80bd\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u4e5f\u53d1\u73b0\u4e86\u4e00\u4e2a\u95ee\u9898\u2014\u2014\u5728\u51cf\u80a5\u8fc7\u7a0b\u4e2d\u808c\u8089\u6d41\u5931\u6bd4\u4f8b\u7ea640%\uff0c\u9ad8\u4e8e\u6b63\u5e38\u8282\u98df\u953b\u70bc\u768425%\u3002\u8fd9\u79cd\u975e\u8102\u80aa\u7ec4\u7ec7\u7684\u6d41\u5931\u5bf9\u8001\u5e74\u4eba\u5f71\u54cd\u66f4\u5927\uff0c\u56e0\u4e3a\u808c\u8089\u4e00\u65e6\u6d41\u5931\u5f88\u96be\u8865\u56de\u6765\u3002<\/p>\n<p>\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u53d1\u4eba\u5458\u6295\u5165\u5927\u91cf\u7cbe\u529b\u63a2\u7d22Amylin\u548cCalcitonin\u9776\u70b9\u3002\u7531\u4e8e\u8fd9\u4e9b\u9776\u70b9\u90fd\u5177\u6709\u03b1\u87ba\u65cb\u7ed3\u6784\uff0c\u4e3a\u8fde\u7528\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u901a\u8fc7\u5c06GLP-1\u548cAmylin\u591a\u80bd\u901a\u8fc7\u8fde\u63a5\u5b50\uff08Linker\uff09\u76f8\u8fde\uff0c\u518d\u8fde\u63a5\u534a\u8870\u671f\u5ef6\u957f\u57fa\u56e2\uff0c\u53ef\u5f62\u6210\u7ea660\u4e2a\u6c28\u57fa\u9178\u7684\u53cc\u91cd\u6fc0\u52a8\u5242\u3002\u66f4\u8fdb\u4e00\u6b65\uff0c2024\u5e74Pep2Tango\u516c\u53f8\u53d1\u8868\u4e13\u5229\uff0c\u5c06\u4e24\u8fb9\u90fd\u505a\u6210\u53cc\u91cd\u6fc0\u52a8\u5242\u518d\u8fde\u63a5\uff0c\u5b9e\u73b0\u4e86\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\u7684\u591a\u91cd\u6fc0\u52a8\u5242\u8bbe\u8ba1\u3002<\/p>\n<p>\u7a33\u5b9a\u6027\u5927\u4f5c\u6218<\/p>\n<p>\u591a\u80bd\u836f\u7269\u6700\u5927\u7684\u6311\u6218\u5728\u4e8e\u7a33\u5b9a\u6027\u95ee\u9898\u2014\u2014\u7531\u4e8e\u5206\u5b50\u91cf\u8f83\u5c0f\uff0c\u5bb9\u6613\u88ab\u80be\u810f\u4ee3\u8c22\u6e05\u9664\uff0c\u540c\u65f6\u7a33\u5b9a\u6027\u5dee\uff0c\u5bb9\u6613\u88ab\u4f53\u5185\u5404\u79cd\u9176\u5206\u89e3\u3002\u5929\u7136\u7684GLP-1\u534a\u8870\u671f\u53ea\u6709\u51e0\u5206\u949f\uff0c\u6839\u672c\u65e0\u6cd5\u76f4\u63a5\u6210\u836f\u3002<\/p>\n<p>\u7a81\u7834\u6765\u81ea\u4e8e\u5de7\u5999\u7684\u5316\u5b66\u4fee\u9970\u7b56\u7565\u3002\u5229\u62c9\u9c81\u80bd\u7684\u7814\u53d1\u4eba\u5458\u5728\u539f\u80bd\u57fa\u7840\u4e0a\u589e\u52a0\u4e86\u4e00\u4e2a\u542bC16\u8102\u80aa\u94fe\u7684\u4fa7\u94fe\uff0c\u8fd9\u4e2a\u4fa7\u94fe\u53ef\u4ee5\u4e0e\u8840\u6e05\u4e2d\u7684\u767d\u86cb\u767d\u8fdb\u884c\u53ef\u9006\u7ed3\u5408\u3002\u901a\u8fc7\u4e0e\u5927\u5206\u5b50\u767d\u86cb\u767d\u7ed3\u5408\uff0c\u5927\u5927\u5ef6\u957f\u4e86\u534a\u8870\u671f\uff0c\u5b9e\u73b0\u4e86\u6bcf\u65e5\u7ed9\u836f\u4e00\u6b21\u7684\u76ee\u6807\u3002\u53f8\u7f8e\u683c\u9c81\u80bd\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u4e0d\u4ec5\u4fdd\u7559\u4e86\u8fd9\u79cd\u7b56\u7565\uff0c\u8fd8\u589e\u52a0\u4e86\u4e00\u4e9b\u6807\u7b7e\u5e8f\u5217\u7684\u6539\u8fdb\uff0c\u63d0\u9ad8\u4e86\u7a33\u5b9a\u6027\u548c\u4eb2\u548c\u529b\u3002<\/p>\n<p>\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u6839\u672c\u6027\u7684\u7a33\u5b9a\u6027\u95ee\u9898\uff0c\u4e1a\u754c\u5f00\u53d1\u4e86\u591a\u79cd\u521b\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002\u6bd4\u5982\uff0c\u975e\u5929\u7136\u6c28\u57fa\u9178\u7684\u5e94\u7528\u3002\u7ef4\u4e9a\u751f\u7269\u5c0f\u5206\u5b50\u56e2\u961f\u62e5\u6709\u53ef\u9009\u62e9\u7684\u6c28\u57fa\u9178\u8d44\u6e90\uff0c\u540c\u65f6\u8ba1\u7b97\u56e2\u961f\u5efa\u7acb\u4e86\u975e\u5929\u7136\u6c28\u57fa\u9178\u5e93\uff0c\u4e3b\u8981\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff1a\u4e00\u90e8\u5206\u662f\u57fa\u4e8e\u5929\u7136\u6c28\u57fa\u9178\u884d\u751f\u7684\u7ed3\u6784\uff0c\u5360\u636e\u7c7b\u4f3c\u7684\u5316\u5b66\u7a7a\u95f4\u4f46\u5177\u6709\u66f4\u5f3a\u7684\u5316\u5b66\u591a\u6837\u6027\uff1b\u53e6\u4e00\u90e8\u5206\u5219\u662f\u4eceFDA\u6279\u51c6\u836f\u7269\u4e2d\u63d0\u53d6\u7684\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ed3\u6784\uff0c\u5927\u6982\u6709100\u591a\u4e2a\u3002<\/p>\n<p>\u8fd9\u4e9b\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ecf\u8fc7\u5b8c\u5168\u7684\u53c2\u6570\u5316\u5904\u7406\uff0c\u5728\u65e5\u5e38\u8bbe\u8ba1\u4e2d\u53ef\u4ee5\u50cf\u5929\u7136\u6c28\u57fa\u9178\u4e00\u6837\u4f7f\u7528\uff0c\u751a\u81f3\u5728\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u4e2d\u4e5f\u6709\u5b8c\u6574\u7684\u529b\u573a\u53c2\u6570\u652f\u6301\uff0c\u53ef\u4ee5\u76f4\u63a5\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\u548c\u4eb2\u548c\u529b\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u7ef4\u4e9a\u8fd8\u62e5\u6709960\u4e2a\u7247\u6bb5\u5316\u5408\u7269\u5e93\uff0c\u4e0d\u4ec5\u7528\u4e8e\u6676\u4f53\u6d78\u6ce1\u5b9e\u9a8c\uff0c\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u5bfb\u627e\u751f\u7269\u7535\u5b50\u7b49\u6392\u4f53\u7684\u91cd\u8981\u8d44\u6e90\u3002<\/p>\n<p>\u9488\u5bf9\u4e3b\u94fe\uff0c\u8ba1\u7b97\u56e2\u961f\u4e5f\u6709\u4e00\u7cfb\u5217\u6539\u9020\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u6c2e\u7532\u57fa\u5316\u548c\u5bf9\u5929\u7136\u80bd\u952e\u7684\u6742\u73af\u5f15\u5165\u7b49\u3002<\/p>\n<p>&#8220;AI+&#8221;\u73af\u80bd\u5408\u6210\u7b56\u7565<\/p>\n<p>\u5728\u89e3\u51b3\u7a33\u5b9a\u6027\u95ee\u9898\u7684\u4f17\u591a\u7b56\u7565\u4e2d\uff0c\u73af\u80bd\u6280\u672f\u5c55\u73b0\u51fa\u4e86\u72ec\u7279\u7684\u4f18\u52bf\u3002\u76f8\u6bd4\u7ebf\u6027\u80bd\uff0c\u73af\u80bd\u4e0d\u4ec5\u7a33\u5b9a\u6027\u66f4\u597d\uff0c\u4eb2\u548c\u529b\u4e5f\u66f4\u5f3a\uff0c\u900f\u819c\u6027\u4e5f\u66f4\u4f73\u3002\u7ef4\u4e9a\u751f\u7269\u5728\u73af\u80bd\u5408\u6210\u65b9\u9762\u79ef\u7d2f\u4e86\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u5df2\u5408\u6210\u8d85\u8fc73000\u6761\u591a\u80bd\uff0c\u5176\u4e2d\u73af\u80bd\u536080%\u4ee5\u4e0a\u3002<\/p>\n<p>\u7ef4\u4e9a\u751f\u7269\u5177\u5907\u591a\u79cd\u6210\u73af\u5316\u5b66\u7b56\u7565\uff0c\u5176\u4e2d\u4e8c\u786b\u952e\u6210\u73af\u662f\u6700\u5e38\u89c1\u7684\u65b9\u5f0f\u3002\u57fa\u4e8e\u5def\u57fa\u7684\u53cd\u5e94\u5305\u62ec\u4e8c\u786b\u952e\u3001\u5def\u919a\u952e\u3001\u53d8\u5def\u919a\u952e\u3001\u6742\u73af\u7684SNAr\u53cd\u5e94\u3001\u7532\u5def\u54aa\u5511\u53cd\u5e94\uff0c\u4ee5\u53ca\u53cc\u952e\u7684\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u9170\u80fa\u952e\u6210\u73af\uff08\u5305\u62ec\u9996\u5c3e\u76f8\u8fde\u548c\u4fa7\u94fe\u6210\u73af\uff09\u3001Click\u5316\u5b66\u53cd\u5e94\u3001\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u7b49\u4e5f\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002<\/p>\n<p>\u53cc\u73af\u80bd\u7684\u5408\u6210\u66f4\u5177\u6311\u6218\u6027\uff0c\u4e0d\u540c\u73af\u5316\u7c7b\u578b\u7684\u7ec4\u5408\u5f62\u6210\u590d\u6742\u7684\u53cc\u73af\u7ed3\u6784\u3002\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5373\u4f7f\u662f\u7b80\u5355\u7684\u4e8c\u786b\u952e\u73af\u80bd\uff0c\u4e5f\u53ef\u80fd\u51fa\u73b0\u6c28\u57fa\u9178\u6d88\u65cb\u7b49\u6280\u672f\u95ee\u9898\uff0c\u9700\u8981\u91c7\u7528\u7279\u6b8a\u7684\u5076\u8054\u65b9\u5f0f\u6765\u6291\u5236\u6d88\u65cb\uff0c\u786e\u4fdd\u4ea7\u54c1\u8d28\u91cf\u3002<\/p>\n<p>\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u4e0e\u5b9e\u9a8c\u5b9e\u73b0\u4e86\u5f88\u597d\u7684\u8054\u52a8\u3002\u4ee5\u4e8c\u786b\u952e\u6210\u73af\u4e3a\u4f8b\uff0c\u8ba1\u7b97\u56e2\u961f\u4f1a\u5728\u6c28\u57fa\u9178\u4e0a\u8fdb\u884c\u534a\u80f1\u6c28\u9178\u7a81\u53d8\uff0c\u5e76\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\uff0c\u89c2\u5bdf\u8fd9\u4e24\u4e2a\u7a81\u53d8\u4f4d\u70b9\u5728\u6784\u8c61\u7a7a\u95f4\u4e2d\u7684\u8ddd\u79bb\u548c\u89d2\u5ea6\u5173\u7cfb\u4ee5\u53ca\u4e3b\u8981\u5206\u5e03\u3002\u6709\u4e86\u8fd9\u4e9b\u4fe1\u606f\uff0c\u5c31\u53ef\u4ee5\u4e0e\u5df2\u6709\u7684\u6210\u73af\u65b9\u5f0f\u8fdb\u884c\u5339\u914d\uff0c\u627e\u5230\u6700\u9002\u5408\u7684\u6210\u73af\u7b56\u7565\u3002\u8fd9\u79cd\u65b9\u6cd5\u540c\u6837\u9002\u7528\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u6210\u73af\u53cd\u5e94\uff0c\u53ea\u9700\u8981\u5c06\u7a81\u53d8\u7684\u6c28\u57fa\u9178\u6362\u6210\u4e19\u6c28\u9178\u6216\u5e26\u6709\u7279\u5b9a\u4fa7\u94fe\u7684\u6c28\u57fa\u9178\u5373\u53ef\u3002<\/p>\n<p>\u5bf9\u4e8e\u66f4\u590d\u6742\u7684\u60c5\u51b5\uff0c\u6bd4\u5982\u4ece\u5934\u8bbe\u8ba1\u73af\u80bd\u65f6\uff0c\u53ef\u4ee5\u4f7f\u7528Rosetta-KIC\uff08Kinetic Loop Modeling\uff09\u7b49\u7ecf\u5178\u65b9\u6cd5\u6765\u627e\u51fa\u7f3a\u5931\u7684\u6c28\u57fa\u9178\u3002\u627e\u5230\u5019\u9009\u5e8f\u5217\u540e\uff0c\u8fd8\u9700\u8981\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u7ed3\u6784\u4f18\u5316\uff0c\u5305\u62ec\u5728\u975e\u7ed3\u5408\u7684\u6eb6\u6db2\u73af\u5883\u4e2d\u8fdb\u884c\u91c7\u6837\uff0c\u8ba1\u7b97\u5e94\u53d8\u80fd\uff08strain energy\uff09\u6765\u8bc4\u4f30\u6210\u73af\u7684\u96be\u6613\u7a0b\u5ea6\u3002<\/p>\n<p>\u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u4f1a\u6bd4\u8f83\u672a\u7ed3\u5408\u72b6\u6001\u4e0e\u590d\u5408\u7269\u7ed3\u6784\u7684\u6784\u8c61\u76f8\u4f3c\u6027\uff0c\u786e\u4fdd\u6700\u7ec8\u7684\u73af\u80bd\u5c3d\u53ef\u80fd\u63a5\u8fd1\u751f\u7269\u6d3b\u6027\u6784\u8c61\u3002\u8fd9\u79cd\u5bf9\u6784\u8c61\u5dee\u5f02\u7684\u5173\u6ce8\uff0c\u80fd\u591f\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u71b5\u60e9\u7f5a\uff0c\u4ece\u800c\u63d0\u9ad8\u591a\u80bd\u7684\u4eb2\u548c\u529b\u548c\u5176\u4ed6\u5173\u952e\u6027\u8d28\u3002<\/p>\n<p>MK-0616\u8bbe\u8ba1\u7cbe\u9ad3\u2014\u2014\u7ed3\u6784\u9a71\u52a8\u7684\u836f\u5316\u8bbe\u8ba1<\/p>\n<p>MK-0616\u4f5c\u4e3a\u9776\u5411PCSK9\u7684\u53e3\u670d\u591a\u80bd\u836f\u7269\uff0c\u8d70\u5728\u4e86\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u7684\u524d\u6cbf\u3002PCSK9\u5bf9\u4e8e\u7ef4\u4e9a\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u719f\u6089\u7684\u9776\u70b9<span>\uff1a\u66fe\u6df1\u5ea6\u53c2\u4e0e<\/span>PCSK9\u5c0f\u5206\u5b50\u7684\u836f\u7269\u7814\u53d1\uff0c\u76ee\u524d\u8be5\u9879\u76ee\u5df2\u7ecf\u8fdb\u5165\u5230\u4e09\u671f\u9636\u6bb5\u3002<\/p>\n<p>MK-0616\u6700\u521d\u662f\u4ecemRNA\u7b5b\u9009\u4e2d\u5f97\u5230\u7684\u5355\u73af\u73af\u80bd\uff0c\u540e\u6765\u7814\u53d1\u4eba\u5458\u5c06\u5176\u6539\u9020\u6210\u4e09\u73af\u80bd\uff0c\u4eb2\u548c\u529b\u6709\u4e86\u663e\u8457\u63d0\u9ad8\u3002\u4ece\u5408\u6210\u5316\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u4e2a\u5206\u5b50\u7684\u5408\u6210\u96be\u5ea6\u6781\u9ad8\uff0c\u8be5\u5168\u5408\u6210\u5de5\u4f5c\u4e8e2025\u5e74\u53d1\u8868\u5728JACS\u4e0a\u3002<\/p>\n<p>\u4ece\u590d\u5408\u7269\u7ed3\u6784\u6765\u770b\uff0c\u52a0\u5165\u7b2c\u4e09\u4e2a\u73af\u540e\u7684\u6676\u4f53\u7ed3\u6784\u4e0e\u53ea\u6709\u4e24\u4e2a\u73af\u65f6\u7684\u7ed3\u6784\u51e0\u4e4e\u5b8c\u5168\u91cd\u53e0\uff0c\u53e0\u5408\u5f97\u975e\u5e38\u597d\u3002\u8fd9\u5c55\u73b0\u4e86\u7ed3\u6784\u751f\u7269\u5b66\u4e0e\u836f\u7269\u5316\u5b66\u7684\u5b8c\u7f8e\u878d\u5408\u3002\u800c\u7ef4\u4e9a\u751f\u7269\u81ea\u6210\u7acb\u8d77\u5c31\u6df1\u8015\u5e03\u5c40\u8fd9\u4e00\u9886\u57df\uff0c\u5e2e\u52a9\u5168\u7403\u6570\u5343\u5bb6\u5ba2\u6237\u653b\u514b\u7ed3\u6784\u751f\u7269\u5b66\u4e16\u754c\u7ea7\u96be\u9898\u3002\u622a\u81f32024\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5df2\u5411\u5168\u7403\u5ba2\u6237\u4ea4\u4ed8\u8d85\u8fc782,000+\u4f8b\u86cb\u767d\u7ed3\u6784\uff0c\u7814\u7a76\u7684\u836f\u7269\u9776\u6807\u6570\u91cf\u7d2f\u8ba1\u7a81\u78342,000\u4e2a\uff0c\u7a33\u5c45\u5168\u7403\u86cb\u767d\u7ed3\u6784\u89e3\u6790\u7684\u5236\u9ad8\u70b9\u524d\u5217\u3002<\/p>\n<p>\u7ef4\u4e9a\u751f\u7269\u7684\u591a\u80bd\u63a2\u7d22\u8def\u5f84<\/p>\n<p>\u7b5b\u9009\u6280\u672f\u7684\u591a\u6837\u5316\u53d1\u5c55<\/p>\n<p>\u968f\u7740\u591a\u80bd\u836f\u7269\u7814\u53d1\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u7814\u53d1\u624b\u6bb5\u4e5f\u5728\u4e0d\u65ad\u8fdb\u6b65\u3002\u4ece\u5b9e\u9a8c\u4e0a\u6765\u770b\uff0c\u4f20\u7edf\u7684\u65b9\u6cd5\u6709\u566c\u83cc\u4f53\u5c55\u793a\u80bd\u5e93\uff0c\u8fd9\u4e2a\u7ef4\u4e9a\u5c31\u6709\u3002\u53e6\u5916\uff0cmRNA\u5c55\u793a\u6280\u672f\u56e0\u4e3a\u53ef\u4ee5\u5305\u542b\u5929\u7136\u548c\u975e\u5929\u7136\u6c28\u57fa\u9178\uff0c\u5728\u73af\u80bd\u5e93\u7b5b\u9009\u4e2d\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u8fd8\u6709\u4e00\u4e2a\u6bd4\u8f83\u6709\u7279\u8272\u7684\u662fDEL\u73af\u80bd\u5e93\u3002<\/p>\n<p>\u7ef4\u4e9a\u751f\u7269\u5efa\u7acb\u4e86\u591a\u4ee3DEL\u73af\u80bd\u5e93\uff1a\u7b2c\u4e00\u4ee3\u7531\u4e09\u4e2abuilding blocks\u548cClick\u5316\u5b66\u5173\u73af\u53cd\u5e94\u7ec4\u6210\uff0c\u73af\u80bd\u957f\u5ea6\u57284-17\u4e2a\u6c28\u57fa\u9178\u8303\u56f4\u5185\uff1b\u5347\u7ea7\u7248\u7684DEL\u73af\u80bd\u5e93\u5305\u542b\u56db\u4e2abuilding blocks\u548c\u591a\u79cd\u5173\u73af\u53cd\u5e94\uff0c\u5355\u73af\u5206\u5b50\u5e93\u8fbe\u52305000\u4ebf\u4e2a\u5316\u5408\u7269\uff0c\u53cc\u73af\u5206\u5b50\u5e93\u4e5f\u6709500\u591a\u4ebf\u4e2a\u5316\u5408\u7269\u3002<\/p>\n<p>\u5728\u8bbe\u8ba1\u8fd9\u4e9b\u5316\u5408\u7269\u5e93\u65f6\uff0c\u56e2\u961f\u7279\u522b\u6ce8\u91cd\u5173\u73af\u53cd\u5e94\u7684\u4ea7\u7387\u9009\u62e9\uff0c\u4ee5\u786e\u4fddDNA\u7b5b\u9009\u7684\u6210\u529f\u7387\u3002\u53e6\u5916\uff0c\u8ba1\u7b97\u4e0eDEL\u7684\u8054\u52a8\uff0c\u8fd8\u5305\u62ec\u4ece\u524d\u671fbuilding blocks\u7684\u9009\u53d6\uff08\u8fd9\u672c\u8eab\u5c31\u4f53\u73b0\u4e86\u4e0e\u9776\u70b9\u76f8\u5173\u7684\u4f9d\u8d56\u6027\uff09\u5230\u540e\u671f\u8fdb\u4e00\u6b65\u82d7\u5934\u5316\u5408\u7269\u7684\u5bcc\u96c6\u5206\u6790\uff0c\u90fd\u9700\u8981\u9ad8\u7cbe\u5ea6\u7684\u8ba1\u7b97\u652f\u6301\uff0c\u4ece\u800c\u4e3a\u540e\u7eed\u7684\u5316\u5408\u7269\u6539\u9020\u548c\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002<\/p>\n<p>\u4ece\u5934\u8bbe\u8ba1\u7684AI\u65b0\u601d\u8def<\/p>\n<p>\u9664\u4e86\u7b5b\u9009\u4ee5\u5916\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u8fd8\u62e5\u6709\u4e00\u6574\u5957\u4ece\u5934\u8bbe\u8ba1\u7684\u65b9\u6cd5\uff0c\u4e3b\u8981\u5206\u4e3a\u4e09\u7c7b\uff1a\u57fa\u4e8e\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u7684\u8bbe\u8ba1\u3001\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4ee5\u53ca\u5b8c\u5168\u57fa\u4e8eAI\u7684\u4ece\u5934\u751f\u6210\u3002<\/p>\n<p>\u73af\u80bd\u4f5c\u4e3aPPI\u5e72\u6270\u5242\u5177\u6709\u72ec\u7279\u4f18\u52bf\uff0c\u4ee5\u4e34\u5e8a\u4e09\u671f\u7684JNJ-2113\u4e3a\u4f8b\uff0c<span>\u7ef4\u4e9a<\/span>\u901a\u8fc7\u590d\u5408\u7269\u7ed3\u6784\u5efa\u6a21\u53d1\u73b0\uff0c\u5176\u7ed3\u5408\u7684\u591a\u80bd\u7247\u6bb5\u4e0e\u539fIL-23 P19\u86cb\u767d\u5728\u76f8\u540c\u4f4d\u7f6e\u5177\u6709\u663e\u8457\u76f8\u4f3c\u6027\uff0c\u7279\u522b\u662f\u4fdd\u5b88\u7684\u8272\u6c28\u9178\uff08Tryptophan\uff09\u7ed3\u6784\u5360\u636e\u4e86\u76f8\u4f3c\u7684\u4f4d\u7f6e\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u4e2a\u591a\u80bd\u6700\u521d\u4e5f\u662f\u901a\u8fc7\u566c\u83cc\u4f53\u5c55\u793a\u7b5b\u9009\u5f97\u5230\u7684\uff0c\u5448\u73b0\u51fa\u4e00\u79cd\u6b8a\u9014\u540c\u5f52\u7684\u6548\u679c\u3002<\/p>\n<p>\u7c7b\u4f3c\u7684\u662f\uff0c\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4e5f\u6d89\u53ca\u5230\u4e86PPI\uff0c\u672c\u8eab\u5177\u6709\u5f88\u5f3a\u7684\u6539\u9020\u7a7a\u95f4\u3002<span>\u7ef4\u4e9a<\/span>\u53ef\u4ee5\u5c06\u5355\u6297\u5207\u5272\u4e3aVHH\uff0cVHH\u53ef\u4ee5\u8fdb\u4e00\u6b65\u51cf\u5c0f\u505a\u6210\u73af\u80bd\u3002<\/p>\n<p>\u8fd8\u6709\u4e00\u79cd\u5b8c\u5168\u7684\u4ece\u5934\u751f\u6210\u65b9\u5f0f\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ea\u9700\u8981\u9776\u86cb\u767d\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u505a\u5168\u65b0\u7684\u591a\u80bd\u8bbe\u8ba1\u3002\u8fd9\u4e9b\u65b9\u6cd5\u53ef\u4ee5\u975e\u5e38\u7075\u6d3b\u5730\u4f7f\u7528\uff0c\u800c\u4e14\u540e\u671f\u8fd8\u53ef\u4ee5\u4e0e\u836f\u7269\u5316\u5b66\u56e2\u961f\u6df1\u5ea6\u5408\u4f5c\uff0c\u5728\u836f\u5316\u5c42\u9762\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4f18\u5316\u3002<\/p>\n<p>\u591a\u80bd\u7814\u53d1\u7684\u65e0\u9650\u53ef\u80fd<\/p>\n<p>\u4ece\u4f20\u7edf\u7684\u7ebf\u6027\u80bd\u5230\u590d\u6742\u7684\u591a\u73af\u7ed3\u6784\uff0c\u4ece\u5355\u4e00\u9776\u70b9\u5230\u591a\u9776\u70b9\u534f\u540c\uff0c\u4ece\u5b9e\u9a8c\u5ba4\u7b5b\u9009\u5230AI\u9a71\u52a8\u7684\u4ece\u5934\u8bbe\u8ba1\uff0c\u6bcf\u4e00\u4e2a\u7a81\u7834\u90fd\u5728\u63a8\u52a8\u7740\u8fd9\u4e2a\u9886\u57df\u5411\u524d\u53d1\u5c55\u3002\u8fd9\u573a\u7531\u6280\u672f\u9a71\u52a8\u7684\u6d6a\u6f6e\u624d\u521a\u521a\u5f00\u59cb\uff0c\u800c\u7ef4\u4e9a\u751f\u7269\u5c06\u7ee7\u7eed\u7ad9\u5728\u8fd9\u573a\u6d6a\u6f6e\u7684\u524d\u6cbf\uff0c\u4e0e\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u4e00\u9053\uff0c\u63a2\u7d22\u591a\u80bd\u836f\u7269\u7684\u65e0\u9650\u53ef\u80fd\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<\/div>\n<p>SOURCE  \u7ef4\u4e9a\u751f\u7269<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772025\u5e747\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4ece\u53f8\u7f8e\u683c\u9c81\u80bd\u6380\u8d77\u7684&#8221;\u51cf\u80a5\u836f\u98ce\u66b4&#8221;\u5230MK-0616\u7684\u4e09\u73af\u80bd\u7a81\u7834\uff0c\u591a\u80bd\u836f\u7269\u6b63\u5728\u91cd\u65b0\u5b9a\u4e49\u751f\u7269\u533b\u836f\u7684\u8fb9\u754c\u3002\u5f53\u4e00\u4e2a60\u591a\u4e2a\u6c28\u57fa\u9178\u7684\u5206\u5b50\u53ef\u4ee5\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\uff0c\u5f53AI\u7b97\u6cd5\u80fd\u591f\u7cbe\u51c6\u9884\u6d4b\u6210\u73af\u7b56\u7565\u7684\u53ef\u884c\u6027&#8230;&#8230;\u8fd9\u4e0d\u4ec5\u4ec5\u662f\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u66f4\u662f\u4e00\u573a\u5173\u4e8e\u672a\u6765\u836f\u7269\u8bbe\u8ba1\u7684\u53d8\u5c40\u3002 \u7ef4\u4e9a\u751f\u7269\u4f5c\u4e3a\u8fd9\u573a\u53d8\u5c40\u7684\u89c1\u8bc1\u8005\u548c\u63a8\u52a8\u8005\uff0c\u63d0\u4f9b\u4ece\u591a\u80bd\u7b5b\u9009\u5230PCC\u7684\u4e00\u4f53\u5316\u7814\u53d1\u670d\u52a1\u3002\u5728\u6700\u65b0\u63a8\u51fa\u7684\u7ef4\u4e9a\u533b\u836f\u89c2\u7cfb\u5217\u4e4b\u300a\u6df1\u5ea6\u5bf9\u8bdd\u4e28\u591a\u80bd\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u8def\u5f84\u63a2\u6790\u300b\u76f4\u64ad\u4e2d\uff0c\u7ef4\u4e9a\u5256\u6790\u4e86\u591a\u4e2a\u7a81\u7834\u6027\u6848\u4f8b\u80cc\u540e\u7684\u6280\u672f\u5bc6\u7801\uff0c\u5e76\u7ed3\u5408\u81ea\u8eab\u6210\u529f\u5b9e\u8df5\uff0c\u4e3a\u4e1a\u754c\u540c\u4ec1\u63d0\u4f9b\u72ec\u5bb6\u7684\u521b\u65b0\u89c6\u89d2\u3002\u9519\u8fc7\u672c\u671f\u76f4\u64ad\u7684\u670b\u53cb\uff0c\u53ef\u4ee5\u5173\u6ce8\u7ef4\u4e9a\u751f\u7269\u300c\u89c6\u9891\u53f7\u300d\u89c2\u770b\u7cbe\u5f69\u56de\u653e\u3002 \u957f\u6548\u5316\u3001\u591a\u9776\u70b9\u8bbe\u8ba1\u7684\u65b0\u8d8b\u52bf \u591a\u80bd\u836f\u7269\u6b63\u671d\u7740\u957f\u6548\u5316\u548c\u591a\u9776\u70b9\u65b9\u5411\u53d1\u5c55\uff0c\u8fd9\u4e00\u8d8b\u52bf\u5728\u6700\u65b0\u7684\u7814\u53d1\u4e2d\u8868\u73b0\u5f97\u5c24\u4e3a\u660e\u663e\u3002\u867d\u7136\u53f8\u7f8e\u683c\u9c81\u80bd\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u4e5f\u53d1\u73b0\u4e86\u4e00\u4e2a\u95ee\u9898\u2014\u2014\u5728\u51cf\u80a5\u8fc7\u7a0b\u4e2d\u808c\u8089\u6d41\u5931\u6bd4\u4f8b\u7ea640%\uff0c\u9ad8\u4e8e\u6b63\u5e38\u8282\u98df\u953b\u70bc\u768425%\u3002\u8fd9\u79cd\u975e\u8102\u80aa\u7ec4\u7ec7\u7684\u6d41\u5931\u5bf9\u8001\u5e74\u4eba\u5f71\u54cd\u66f4\u5927\uff0c\u56e0\u4e3a\u808c\u8089\u4e00\u65e6\u6d41\u5931\u5f88\u96be\u8865\u56de\u6765\u3002 \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u53d1\u4eba\u5458\u6295\u5165\u5927\u91cf\u7cbe\u529b\u63a2\u7d22Amylin\u548cCalcitonin\u9776\u70b9\u3002\u7531\u4e8e\u8fd9\u4e9b\u9776\u70b9\u90fd\u5177\u6709\u03b1\u87ba\u65cb\u7ed3\u6784\uff0c\u4e3a\u8fde\u7528\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u901a\u8fc7\u5c06GLP-1\u548cAmylin\u591a\u80bd\u901a\u8fc7\u8fde\u63a5\u5b50\uff08Linker\uff09\u76f8\u8fde\uff0c\u518d\u8fde\u63a5\u534a\u8870\u671f\u5ef6\u957f\u57fa\u56e2\uff0c\u53ef\u5f62\u6210\u7ea660\u4e2a\u6c28\u57fa\u9178\u7684\u53cc\u91cd\u6fc0\u52a8\u5242\u3002\u66f4\u8fdb\u4e00\u6b65\uff0c2024\u5e74Pep2Tango\u516c\u53f8\u53d1\u8868\u4e13\u5229\uff0c\u5c06\u4e24\u8fb9\u90fd\u505a\u6210\u53cc\u91cd\u6fc0\u52a8\u5242\u518d\u8fde\u63a5\uff0c\u5b9e\u73b0\u4e86\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\u7684\u591a\u91cd\u6fc0\u52a8\u5242\u8bbe\u8ba1\u3002 \u7a33\u5b9a\u6027\u5927\u4f5c\u6218 \u591a\u80bd\u836f\u7269\u6700\u5927\u7684\u6311\u6218\u5728\u4e8e\u7a33\u5b9a\u6027\u95ee\u9898\u2014\u2014\u7531\u4e8e\u5206\u5b50\u91cf\u8f83\u5c0f\uff0c\u5bb9\u6613\u88ab\u80be\u810f\u4ee3\u8c22\u6e05\u9664\uff0c\u540c\u65f6\u7a33\u5b9a\u6027\u5dee\uff0c\u5bb9\u6613\u88ab\u4f53\u5185\u5404\u79cd\u9176\u5206\u89e3\u3002\u5929\u7136\u7684GLP-1\u534a\u8870\u671f\u53ea\u6709\u51e0\u5206\u949f\uff0c\u6839\u672c\u65e0\u6cd5\u76f4\u63a5\u6210\u836f\u3002 \u7a81\u7834\u6765\u81ea\u4e8e\u5de7\u5999\u7684\u5316\u5b66\u4fee\u9970\u7b56\u7565\u3002\u5229\u62c9\u9c81\u80bd\u7684\u7814\u53d1\u4eba\u5458\u5728\u539f\u80bd\u57fa\u7840\u4e0a\u589e\u52a0\u4e86\u4e00\u4e2a\u542bC16\u8102\u80aa\u94fe\u7684\u4fa7\u94fe\uff0c\u8fd9\u4e2a\u4fa7\u94fe\u53ef\u4ee5\u4e0e\u8840\u6e05\u4e2d\u7684\u767d\u86cb\u767d\u8fdb\u884c\u53ef\u9006\u7ed3\u5408\u3002\u901a\u8fc7\u4e0e\u5927\u5206\u5b50\u767d\u86cb\u767d\u7ed3\u5408\uff0c\u5927\u5927\u5ef6\u957f\u4e86\u534a\u8870\u671f\uff0c\u5b9e\u73b0\u4e86\u6bcf\u65e5\u7ed9\u836f\u4e00\u6b21\u7684\u76ee\u6807\u3002\u53f8\u7f8e\u683c\u9c81\u80bd\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u4e0d\u4ec5\u4fdd\u7559\u4e86\u8fd9\u79cd\u7b56\u7565\uff0c\u8fd8\u589e\u52a0\u4e86\u4e00\u4e9b\u6807\u7b7e\u5e8f\u5217\u7684\u6539\u8fdb\uff0c\u63d0\u9ad8\u4e86\u7a33\u5b9a\u6027\u548c\u4eb2\u548c\u529b\u3002 \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u6839\u672c\u6027\u7684\u7a33\u5b9a\u6027\u95ee\u9898\uff0c\u4e1a\u754c\u5f00\u53d1\u4e86\u591a\u79cd\u521b\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002\u6bd4\u5982\uff0c\u975e\u5929\u7136\u6c28\u57fa\u9178\u7684\u5e94\u7528\u3002\u7ef4\u4e9a\u751f\u7269\u5c0f\u5206\u5b50\u56e2\u961f\u62e5\u6709\u53ef\u9009\u62e9\u7684\u6c28\u57fa\u9178\u8d44\u6e90\uff0c\u540c\u65f6\u8ba1\u7b97\u56e2\u961f\u5efa\u7acb\u4e86\u975e\u5929\u7136\u6c28\u57fa\u9178\u5e93\uff0c\u4e3b\u8981\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff1a\u4e00\u90e8\u5206\u662f\u57fa\u4e8e\u5929\u7136\u6c28\u57fa\u9178\u884d\u751f\u7684\u7ed3\u6784\uff0c\u5360\u636e\u7c7b\u4f3c\u7684\u5316\u5b66\u7a7a\u95f4\u4f46\u5177\u6709\u66f4\u5f3a\u7684\u5316\u5b66\u591a\u6837\u6027\uff1b\u53e6\u4e00\u90e8\u5206\u5219\u662f\u4eceFDA\u6279\u51c6\u836f\u7269\u4e2d\u63d0\u53d6\u7684\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ed3\u6784\uff0c\u5927\u6982\u6709100\u591a\u4e2a\u3002 \u8fd9\u4e9b\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ecf\u8fc7\u5b8c\u5168\u7684\u53c2\u6570\u5316\u5904\u7406\uff0c\u5728\u65e5\u5e38\u8bbe\u8ba1\u4e2d\u53ef\u4ee5\u50cf\u5929\u7136\u6c28\u57fa\u9178\u4e00\u6837\u4f7f\u7528\uff0c\u751a\u81f3\u5728\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u4e2d\u4e5f\u6709\u5b8c\u6574\u7684\u529b\u573a\u53c2\u6570\u652f\u6301\uff0c\u53ef\u4ee5\u76f4\u63a5\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\u548c\u4eb2\u548c\u529b\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u7ef4\u4e9a\u8fd8\u62e5\u6709960\u4e2a\u7247\u6bb5\u5316\u5408\u7269\u5e93\uff0c\u4e0d\u4ec5\u7528\u4e8e\u6676\u4f53\u6d78\u6ce1\u5b9e\u9a8c\uff0c\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u5bfb\u627e\u751f\u7269\u7535\u5b50\u7b49\u6392\u4f53\u7684\u91cd\u8981\u8d44\u6e90\u3002 \u9488\u5bf9\u4e3b\u94fe\uff0c\u8ba1\u7b97\u56e2\u961f\u4e5f\u6709\u4e00\u7cfb\u5217\u6539\u9020\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u6c2e\u7532\u57fa\u5316\u548c\u5bf9\u5929\u7136\u80bd\u952e\u7684\u6742\u73af\u5f15\u5165\u7b49\u3002 &#8220;AI+&#8221;\u73af\u80bd\u5408\u6210\u7b56\u7565 \u5728\u89e3\u51b3\u7a33\u5b9a\u6027\u95ee\u9898\u7684\u4f17\u591a\u7b56\u7565\u4e2d\uff0c\u73af\u80bd\u6280\u672f\u5c55\u73b0\u51fa\u4e86\u72ec\u7279\u7684\u4f18\u52bf\u3002\u76f8\u6bd4\u7ebf\u6027\u80bd\uff0c\u73af\u80bd\u4e0d\u4ec5\u7a33\u5b9a\u6027\u66f4\u597d\uff0c\u4eb2\u548c\u529b\u4e5f\u66f4\u5f3a\uff0c\u900f\u819c\u6027\u4e5f\u66f4\u4f73\u3002\u7ef4\u4e9a\u751f\u7269\u5728\u73af\u80bd\u5408\u6210\u65b9\u9762\u79ef\u7d2f\u4e86\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u5df2\u5408\u6210\u8d85\u8fc73000\u6761\u591a\u80bd\uff0c\u5176\u4e2d\u73af\u80bd\u536080%\u4ee5\u4e0a\u3002 \u7ef4\u4e9a\u751f\u7269\u5177\u5907\u591a\u79cd\u6210\u73af\u5316\u5b66\u7b56\u7565\uff0c\u5176\u4e2d\u4e8c\u786b\u952e\u6210\u73af\u662f\u6700\u5e38\u89c1\u7684\u65b9\u5f0f\u3002\u57fa\u4e8e\u5def\u57fa\u7684\u53cd\u5e94\u5305\u62ec\u4e8c\u786b\u952e\u3001\u5def\u919a\u952e\u3001\u53d8\u5def\u919a\u952e\u3001\u6742\u73af\u7684SNAr\u53cd\u5e94\u3001\u7532\u5def\u54aa\u5511\u53cd\u5e94\uff0c\u4ee5\u53ca\u53cc\u952e\u7684\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u9170\u80fa\u952e\u6210\u73af\uff08\u5305\u62ec\u9996\u5c3e\u76f8\u8fde\u548c\u4fa7\u94fe\u6210\u73af\uff09\u3001Click\u5316\u5b66\u53cd\u5e94\u3001\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u7b49\u4e5f\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002 \u53cc\u73af\u80bd\u7684\u5408\u6210\u66f4\u5177\u6311\u6218\u6027\uff0c\u4e0d\u540c\u73af\u5316\u7c7b\u578b\u7684\u7ec4\u5408\u5f62\u6210\u590d\u6742\u7684\u53cc\u73af\u7ed3\u6784\u3002\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5373\u4f7f\u662f\u7b80\u5355\u7684\u4e8c\u786b\u952e\u73af\u80bd\uff0c\u4e5f\u53ef\u80fd\u51fa\u73b0\u6c28\u57fa\u9178\u6d88\u65cb\u7b49\u6280\u672f\u95ee\u9898\uff0c\u9700\u8981\u91c7\u7528\u7279\u6b8a\u7684\u5076\u8054\u65b9\u5f0f\u6765\u6291\u5236\u6d88\u65cb\uff0c\u786e\u4fdd\u4ea7\u54c1\u8d28\u91cf\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u4e0e\u5b9e\u9a8c\u5b9e\u73b0\u4e86\u5f88\u597d\u7684\u8054\u52a8\u3002\u4ee5\u4e8c\u786b\u952e\u6210\u73af\u4e3a\u4f8b\uff0c\u8ba1\u7b97\u56e2\u961f\u4f1a\u5728\u6c28\u57fa\u9178\u4e0a\u8fdb\u884c\u534a\u80f1\u6c28\u9178\u7a81\u53d8\uff0c\u5e76\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\uff0c\u89c2\u5bdf\u8fd9\u4e24\u4e2a\u7a81\u53d8\u4f4d\u70b9\u5728\u6784\u8c61\u7a7a\u95f4\u4e2d\u7684\u8ddd\u79bb\u548c\u89d2\u5ea6\u5173\u7cfb\u4ee5\u53ca\u4e3b\u8981\u5206\u5e03\u3002\u6709\u4e86\u8fd9\u4e9b\u4fe1\u606f\uff0c\u5c31\u53ef\u4ee5\u4e0e\u5df2\u6709\u7684\u6210\u73af\u65b9\u5f0f\u8fdb\u884c\u5339\u914d\uff0c\u627e\u5230\u6700\u9002\u5408\u7684\u6210\u73af\u7b56\u7565\u3002\u8fd9\u79cd\u65b9\u6cd5\u540c\u6837\u9002\u7528\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u6210\u73af\u53cd\u5e94\uff0c\u53ea\u9700\u8981\u5c06\u7a81\u53d8\u7684\u6c28\u57fa\u9178\u6362\u6210\u4e19\u6c28\u9178\u6216\u5e26\u6709\u7279\u5b9a\u4fa7\u94fe\u7684\u6c28\u57fa\u9178\u5373\u53ef\u3002 \u5bf9\u4e8e\u66f4\u590d\u6742\u7684\u60c5\u51b5\uff0c\u6bd4\u5982\u4ece\u5934\u8bbe\u8ba1\u73af\u80bd\u65f6\uff0c\u53ef\u4ee5\u4f7f\u7528Rosetta-KIC\uff08Kinetic Loop Modeling\uff09\u7b49\u7ecf\u5178\u65b9\u6cd5\u6765\u627e\u51fa\u7f3a\u5931\u7684\u6c28\u57fa\u9178\u3002\u627e\u5230\u5019\u9009\u5e8f\u5217\u540e\uff0c\u8fd8\u9700\u8981\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u7ed3\u6784\u4f18\u5316\uff0c\u5305\u62ec\u5728\u975e\u7ed3\u5408\u7684\u6eb6\u6db2\u73af\u5883\u4e2d\u8fdb\u884c\u91c7\u6837\uff0c\u8ba1\u7b97\u5e94\u53d8\u80fd\uff08strain energy\uff09\u6765\u8bc4\u4f30\u6210\u73af\u7684\u96be\u6613\u7a0b\u5ea6\u3002 \u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u4f1a\u6bd4\u8f83\u672a\u7ed3\u5408\u72b6\u6001\u4e0e\u590d\u5408\u7269\u7ed3\u6784\u7684\u6784\u8c61\u76f8\u4f3c\u6027\uff0c\u786e\u4fdd\u6700\u7ec8\u7684\u73af\u80bd\u5c3d\u53ef\u80fd\u63a5\u8fd1\u751f\u7269\u6d3b\u6027\u6784\u8c61\u3002\u8fd9\u79cd\u5bf9\u6784\u8c61\u5dee\u5f02\u7684\u5173\u6ce8\uff0c\u80fd\u591f\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u71b5\u60e9\u7f5a\uff0c\u4ece\u800c\u63d0\u9ad8\u591a\u80bd\u7684\u4eb2\u548c\u529b\u548c\u5176\u4ed6\u5173\u952e\u6027\u8d28\u3002 MK-0616\u8bbe\u8ba1\u7cbe\u9ad3\u2014\u2014\u7ed3\u6784\u9a71\u52a8\u7684\u836f\u5316\u8bbe\u8ba1 MK-0616\u4f5c\u4e3a\u9776\u5411PCSK9\u7684\u53e3\u670d\u591a\u80bd\u836f\u7269\uff0c\u8d70\u5728\u4e86\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u7684\u524d\u6cbf\u3002PCSK9\u5bf9\u4e8e\u7ef4\u4e9a\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u719f\u6089\u7684\u9776\u70b9\uff1a\u66fe\u6df1\u5ea6\u53c2\u4e0ePCSK9\u5c0f\u5206\u5b50\u7684\u836f\u7269\u7814\u53d1\uff0c\u76ee\u524d\u8be5\u9879\u76ee\u5df2\u7ecf\u8fdb\u5165\u5230\u4e09\u671f\u9636\u6bb5\u3002 MK-0616\u6700\u521d\u662f\u4ecemRNA\u7b5b\u9009\u4e2d\u5f97\u5230\u7684\u5355\u73af\u73af\u80bd\uff0c\u540e\u6765\u7814\u53d1\u4eba\u5458\u5c06\u5176\u6539\u9020\u6210\u4e09\u73af\u80bd\uff0c\u4eb2\u548c\u529b\u6709\u4e86\u663e\u8457\u63d0\u9ad8\u3002\u4ece\u5408\u6210\u5316\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u4e2a\u5206\u5b50\u7684\u5408\u6210\u96be\u5ea6\u6781\u9ad8\uff0c\u8be5\u5168\u5408\u6210\u5de5\u4f5c\u4e8e2025\u5e74\u53d1\u8868\u5728JACS\u4e0a\u3002 \u4ece\u590d\u5408\u7269\u7ed3\u6784\u6765\u770b\uff0c\u52a0\u5165\u7b2c\u4e09\u4e2a\u73af\u540e\u7684\u6676\u4f53\u7ed3\u6784\u4e0e\u53ea\u6709\u4e24\u4e2a\u73af\u65f6\u7684\u7ed3\u6784\u51e0\u4e4e\u5b8c\u5168\u91cd\u53e0\uff0c\u53e0\u5408\u5f97\u975e\u5e38\u597d\u3002\u8fd9\u5c55\u73b0\u4e86\u7ed3\u6784\u751f\u7269\u5b66\u4e0e\u836f\u7269\u5316\u5b66\u7684\u5b8c\u7f8e\u878d\u5408\u3002\u800c\u7ef4\u4e9a\u751f\u7269\u81ea\u6210\u7acb\u8d77\u5c31\u6df1\u8015\u5e03\u5c40\u8fd9\u4e00\u9886\u57df\uff0c\u5e2e\u52a9\u5168\u7403\u6570\u5343\u5bb6\u5ba2\u6237\u653b\u514b\u7ed3\u6784\u751f\u7269\u5b66\u4e16\u754c\u7ea7\u96be\u9898\u3002\u622a\u81f32024\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5df2\u5411\u5168\u7403\u5ba2\u6237\u4ea4\u4ed8\u8d85\u8fc782,000+\u4f8b\u86cb\u767d\u7ed3\u6784\uff0c\u7814\u7a76\u7684\u836f\u7269\u9776\u6807\u6570\u91cf\u7d2f\u8ba1\u7a81\u78342,000\u4e2a\uff0c\u7a33\u5c45\u5168\u7403\u86cb\u767d\u7ed3\u6784\u89e3\u6790\u7684\u5236\u9ad8\u70b9\u524d\u5217\u3002 \u7ef4\u4e9a\u751f\u7269\u7684\u591a\u80bd\u63a2\u7d22\u8def\u5f84 \u7b5b\u9009\u6280\u672f\u7684\u591a\u6837\u5316\u53d1\u5c55 \u968f\u7740\u591a\u80bd\u836f\u7269\u7814\u53d1\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u7814\u53d1\u624b\u6bb5\u4e5f\u5728\u4e0d\u65ad\u8fdb\u6b65\u3002\u4ece\u5b9e\u9a8c\u4e0a\u6765\u770b\uff0c\u4f20\u7edf\u7684\u65b9\u6cd5\u6709\u566c\u83cc\u4f53\u5c55\u793a\u80bd\u5e93\uff0c\u8fd9\u4e2a\u7ef4\u4e9a\u5c31\u6709\u3002\u53e6\u5916\uff0cmRNA\u5c55\u793a\u6280\u672f\u56e0\u4e3a\u53ef\u4ee5\u5305\u542b\u5929\u7136\u548c\u975e\u5929\u7136\u6c28\u57fa\u9178\uff0c\u5728\u73af\u80bd\u5e93\u7b5b\u9009\u4e2d\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u8fd8\u6709\u4e00\u4e2a\u6bd4\u8f83\u6709\u7279\u8272\u7684\u662fDEL\u73af\u80bd\u5e93\u3002 \u7ef4\u4e9a\u751f\u7269\u5efa\u7acb\u4e86\u591a\u4ee3DEL\u73af\u80bd\u5e93\uff1a\u7b2c\u4e00\u4ee3\u7531\u4e09\u4e2abuilding blocks\u548cClick\u5316\u5b66\u5173\u73af\u53cd\u5e94\u7ec4\u6210\uff0c\u73af\u80bd\u957f\u5ea6\u57284-17\u4e2a\u6c28\u57fa\u9178\u8303\u56f4\u5185\uff1b\u5347\u7ea7\u7248\u7684DEL\u73af\u80bd\u5e93\u5305\u542b\u56db\u4e2abuilding blocks\u548c\u591a\u79cd\u5173\u73af\u53cd\u5e94\uff0c\u5355\u73af\u5206\u5b50\u5e93\u8fbe\u52305000\u4ebf\u4e2a\u5316\u5408\u7269\uff0c\u53cc\u73af\u5206\u5b50\u5e93\u4e5f\u6709500\u591a\u4ebf\u4e2a\u5316\u5408\u7269\u3002 \u5728\u8bbe\u8ba1\u8fd9\u4e9b\u5316\u5408\u7269\u5e93\u65f6\uff0c\u56e2\u961f\u7279\u522b\u6ce8\u91cd\u5173\u73af\u53cd\u5e94\u7684\u4ea7\u7387\u9009\u62e9\uff0c\u4ee5\u786e\u4fddDNA\u7b5b\u9009\u7684\u6210\u529f\u7387\u3002\u53e6\u5916\uff0c\u8ba1\u7b97\u4e0eDEL\u7684\u8054\u52a8\uff0c\u8fd8\u5305\u62ec\u4ece\u524d\u671fbuilding blocks\u7684\u9009\u53d6\uff08\u8fd9\u672c\u8eab\u5c31\u4f53\u73b0\u4e86\u4e0e\u9776\u70b9\u76f8\u5173\u7684\u4f9d\u8d56\u6027\uff09\u5230\u540e\u671f\u8fdb\u4e00\u6b65\u82d7\u5934\u5316\u5408\u7269\u7684\u5bcc\u96c6\u5206\u6790\uff0c\u90fd\u9700\u8981\u9ad8\u7cbe\u5ea6\u7684\u8ba1\u7b97\u652f\u6301\uff0c\u4ece\u800c\u4e3a\u540e\u7eed\u7684\u5316\u5408\u7269\u6539\u9020\u548c\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002 \u4ece\u5934\u8bbe\u8ba1\u7684AI\u65b0\u601d\u8def \u9664\u4e86\u7b5b\u9009\u4ee5\u5916\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u8fd8\u62e5\u6709\u4e00\u6574\u5957\u4ece\u5934\u8bbe\u8ba1\u7684\u65b9\u6cd5\uff0c\u4e3b\u8981\u5206\u4e3a\u4e09\u7c7b\uff1a\u57fa\u4e8e\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u7684\u8bbe\u8ba1\u3001\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4ee5\u53ca\u5b8c\u5168\u57fa\u4e8eAI\u7684\u4ece\u5934\u751f\u6210\u3002 \u73af\u80bd\u4f5c\u4e3aPPI\u5e72\u6270\u5242\u5177\u6709\u72ec\u7279\u4f18\u52bf\uff0c\u4ee5\u4e34\u5e8a\u4e09\u671f\u7684JNJ-2113\u4e3a\u4f8b\uff0c\u7ef4\u4e9a\u901a\u8fc7\u590d\u5408\u7269\u7ed3\u6784\u5efa\u6a21\u53d1\u73b0\uff0c\u5176\u7ed3\u5408\u7684\u591a\u80bd\u7247\u6bb5\u4e0e\u539fIL-23 P19\u86cb\u767d\u5728\u76f8\u540c\u4f4d\u7f6e\u5177\u6709\u663e\u8457\u76f8\u4f3c\u6027\uff0c\u7279\u522b\u662f\u4fdd\u5b88\u7684\u8272\u6c28\u9178\uff08Tryptophan\uff09\u7ed3\u6784\u5360\u636e\u4e86\u76f8\u4f3c\u7684\u4f4d\u7f6e\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u4e2a\u591a\u80bd\u6700\u521d\u4e5f\u662f\u901a\u8fc7\u566c\u83cc\u4f53\u5c55\u793a\u7b5b\u9009\u5f97\u5230\u7684\uff0c\u5448\u73b0\u51fa\u4e00\u79cd\u6b8a\u9014\u540c\u5f52\u7684\u6548\u679c\u3002 \u7c7b\u4f3c\u7684\u662f\uff0c\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4e5f\u6d89\u53ca\u5230\u4e86PPI\uff0c\u672c\u8eab\u5177\u6709\u5f88\u5f3a\u7684\u6539\u9020\u7a7a\u95f4\u3002\u7ef4\u4e9a\u53ef\u4ee5\u5c06\u5355\u6297\u5207\u5272\u4e3aVHH\uff0cVHH\u53ef\u4ee5\u8fdb\u4e00\u6b65\u51cf\u5c0f\u505a\u6210\u73af\u80bd\u3002 \u8fd8\u6709\u4e00\u79cd\u5b8c\u5168\u7684\u4ece\u5934\u751f\u6210\u65b9\u5f0f\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ea\u9700\u8981\u9776\u86cb\u767d\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u505a\u5168\u65b0\u7684\u591a\u80bd\u8bbe\u8ba1\u3002\u8fd9\u4e9b\u65b9\u6cd5\u53ef\u4ee5\u975e\u5e38\u7075\u6d3b\u5730\u4f7f\u7528\uff0c\u800c\u4e14\u540e\u671f\u8fd8\u53ef\u4ee5\u4e0e\u836f\u7269\u5316\u5b66\u56e2\u961f\u6df1\u5ea6\u5408\u4f5c\uff0c\u5728\u836f\u5316\u5c42\u9762\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4f18\u5316\u3002 \u591a\u80bd\u7814\u53d1\u7684\u65e0\u9650\u53ef\u80fd \u4ece\u4f20\u7edf\u7684\u7ebf\u6027\u80bd\u5230\u590d\u6742\u7684\u591a\u73af\u7ed3\u6784\uff0c\u4ece\u5355\u4e00\u9776\u70b9\u5230\u591a\u9776\u70b9\u534f\u540c\uff0c\u4ece\u5b9e\u9a8c\u5ba4\u7b5b\u9009\u5230AI\u9a71\u52a8\u7684\u4ece\u5934\u8bbe\u8ba1\uff0c\u6bcf\u4e00\u4e2a\u7a81\u7834\u90fd\u5728\u63a8\u52a8\u7740\u8fd9\u4e2a\u9886\u57df\u5411\u524d\u53d1\u5c55\u3002\u8fd9\u573a\u7531\u6280\u672f\u9a71\u52a8\u7684\u6d6a\u6f6e\u624d\u521a\u521a\u5f00\u59cb\uff0c\u800c\u7ef4\u4e9a\u751f\u7269\u5c06\u7ee7\u7eed\u7ad9\u5728\u8fd9\u573a\u6d6a\u6f6e\u7684\u524d\u6cbf\uff0c\u4e0e\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u4e00\u9053\uff0c\u63a2\u7d22\u591a\u80bd\u836f\u7269\u7684\u65e0\u9650\u53ef\u80fd\u3002 SOURCE \u7ef4\u4e9a\u751f\u7269<\/p>\n","protected":false},"author":0,"featured_media":13996,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-13995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eai\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d772025\u5e747\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4ece\u53f8\u7f8e\u683c\u9c81\u80bd\u6380\u8d77\u7684&#8221;\u51cf\u80a5\u836f\u98ce\u66b4&#8221;\u5230MK-0616\u7684\u4e09\u73af\u80bd\u7a81\u7834\uff0c\u591a\u80bd\u836f\u7269\u6b63\u5728\u91cd\u65b0\u5b9a\u4e49\u751f\u7269\u533b\u836f\u7684\u8fb9\u754c\u3002\u5f53\u4e00\u4e2a60\u591a\u4e2a\u6c28\u57fa\u9178\u7684\u5206\u5b50\u53ef\u4ee5\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\uff0c\u5f53AI\u7b97\u6cd5\u80fd\u591f\u7cbe\u51c6\u9884\u6d4b\u6210\u73af\u7b56\u7565\u7684\u53ef\u884c\u6027&#8230;&#8230;\u8fd9\u4e0d\u4ec5\u4ec5\u662f\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u66f4\u662f\u4e00\u573a\u5173\u4e8e\u672a\u6765\u836f\u7269\u8bbe\u8ba1\u7684\u53d8\u5c40\u3002 \u7ef4\u4e9a\u751f\u7269\u4f5c\u4e3a\u8fd9\u573a\u53d8\u5c40\u7684\u89c1\u8bc1\u8005\u548c\u63a8\u52a8\u8005\uff0c\u63d0\u4f9b\u4ece\u591a\u80bd\u7b5b\u9009\u5230PCC\u7684\u4e00\u4f53\u5316\u7814\u53d1\u670d\u52a1\u3002\u5728\u6700\u65b0\u63a8\u51fa\u7684\u7ef4\u4e9a\u533b\u836f\u89c2\u7cfb\u5217\u4e4b\u300a\u6df1\u5ea6\u5bf9\u8bdd\u4e28\u591a\u80bd\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u8def\u5f84\u63a2\u6790\u300b\u76f4\u64ad\u4e2d\uff0c\u7ef4\u4e9a\u5256\u6790\u4e86\u591a\u4e2a\u7a81\u7834\u6027\u6848\u4f8b\u80cc\u540e\u7684\u6280\u672f\u5bc6\u7801\uff0c\u5e76\u7ed3\u5408\u81ea\u8eab\u6210\u529f\u5b9e\u8df5\uff0c\u4e3a\u4e1a\u754c\u540c\u4ec1\u63d0\u4f9b\u72ec\u5bb6\u7684\u521b\u65b0\u89c6\u89d2\u3002\u9519\u8fc7\u672c\u671f\u76f4\u64ad\u7684\u670b\u53cb\uff0c\u53ef\u4ee5\u5173\u6ce8\u7ef4\u4e9a\u751f\u7269\u300c\u89c6\u9891\u53f7\u300d\u89c2\u770b\u7cbe\u5f69\u56de\u653e\u3002 \u957f\u6548\u5316\u3001\u591a\u9776\u70b9\u8bbe\u8ba1\u7684\u65b0\u8d8b\u52bf \u591a\u80bd\u836f\u7269\u6b63\u671d\u7740\u957f\u6548\u5316\u548c\u591a\u9776\u70b9\u65b9\u5411\u53d1\u5c55\uff0c\u8fd9\u4e00\u8d8b\u52bf\u5728\u6700\u65b0\u7684\u7814\u53d1\u4e2d\u8868\u73b0\u5f97\u5c24\u4e3a\u660e\u663e\u3002\u867d\u7136\u53f8\u7f8e\u683c\u9c81\u80bd\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u4e5f\u53d1\u73b0\u4e86\u4e00\u4e2a\u95ee\u9898\u2014\u2014\u5728\u51cf\u80a5\u8fc7\u7a0b\u4e2d\u808c\u8089\u6d41\u5931\u6bd4\u4f8b\u7ea640%\uff0c\u9ad8\u4e8e\u6b63\u5e38\u8282\u98df\u953b\u70bc\u768425%\u3002\u8fd9\u79cd\u975e\u8102\u80aa\u7ec4\u7ec7\u7684\u6d41\u5931\u5bf9\u8001\u5e74\u4eba\u5f71\u54cd\u66f4\u5927\uff0c\u56e0\u4e3a\u808c\u8089\u4e00\u65e6\u6d41\u5931\u5f88\u96be\u8865\u56de\u6765\u3002 \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u53d1\u4eba\u5458\u6295\u5165\u5927\u91cf\u7cbe\u529b\u63a2\u7d22Amylin\u548cCalcitonin\u9776\u70b9\u3002\u7531\u4e8e\u8fd9\u4e9b\u9776\u70b9\u90fd\u5177\u6709\u03b1\u87ba\u65cb\u7ed3\u6784\uff0c\u4e3a\u8fde\u7528\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u901a\u8fc7\u5c06GLP-1\u548cAmylin\u591a\u80bd\u901a\u8fc7\u8fde\u63a5\u5b50\uff08Linker\uff09\u76f8\u8fde\uff0c\u518d\u8fde\u63a5\u534a\u8870\u671f\u5ef6\u957f\u57fa\u56e2\uff0c\u53ef\u5f62\u6210\u7ea660\u4e2a\u6c28\u57fa\u9178\u7684\u53cc\u91cd\u6fc0\u52a8\u5242\u3002\u66f4\u8fdb\u4e00\u6b65\uff0c2024\u5e74Pep2Tango\u516c\u53f8\u53d1\u8868\u4e13\u5229\uff0c\u5c06\u4e24\u8fb9\u90fd\u505a\u6210\u53cc\u91cd\u6fc0\u52a8\u5242\u518d\u8fde\u63a5\uff0c\u5b9e\u73b0\u4e86\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\u7684\u591a\u91cd\u6fc0\u52a8\u5242\u8bbe\u8ba1\u3002 \u7a33\u5b9a\u6027\u5927\u4f5c\u6218 \u591a\u80bd\u836f\u7269\u6700\u5927\u7684\u6311\u6218\u5728\u4e8e\u7a33\u5b9a\u6027\u95ee\u9898\u2014\u2014\u7531\u4e8e\u5206\u5b50\u91cf\u8f83\u5c0f\uff0c\u5bb9\u6613\u88ab\u80be\u810f\u4ee3\u8c22\u6e05\u9664\uff0c\u540c\u65f6\u7a33\u5b9a\u6027\u5dee\uff0c\u5bb9\u6613\u88ab\u4f53\u5185\u5404\u79cd\u9176\u5206\u89e3\u3002\u5929\u7136\u7684GLP-1\u534a\u8870\u671f\u53ea\u6709\u51e0\u5206\u949f\uff0c\u6839\u672c\u65e0\u6cd5\u76f4\u63a5\u6210\u836f\u3002 \u7a81\u7834\u6765\u81ea\u4e8e\u5de7\u5999\u7684\u5316\u5b66\u4fee\u9970\u7b56\u7565\u3002\u5229\u62c9\u9c81\u80bd\u7684\u7814\u53d1\u4eba\u5458\u5728\u539f\u80bd\u57fa\u7840\u4e0a\u589e\u52a0\u4e86\u4e00\u4e2a\u542bC16\u8102\u80aa\u94fe\u7684\u4fa7\u94fe\uff0c\u8fd9\u4e2a\u4fa7\u94fe\u53ef\u4ee5\u4e0e\u8840\u6e05\u4e2d\u7684\u767d\u86cb\u767d\u8fdb\u884c\u53ef\u9006\u7ed3\u5408\u3002\u901a\u8fc7\u4e0e\u5927\u5206\u5b50\u767d\u86cb\u767d\u7ed3\u5408\uff0c\u5927\u5927\u5ef6\u957f\u4e86\u534a\u8870\u671f\uff0c\u5b9e\u73b0\u4e86\u6bcf\u65e5\u7ed9\u836f\u4e00\u6b21\u7684\u76ee\u6807\u3002\u53f8\u7f8e\u683c\u9c81\u80bd\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u4e0d\u4ec5\u4fdd\u7559\u4e86\u8fd9\u79cd\u7b56\u7565\uff0c\u8fd8\u589e\u52a0\u4e86\u4e00\u4e9b\u6807\u7b7e\u5e8f\u5217\u7684\u6539\u8fdb\uff0c\u63d0\u9ad8\u4e86\u7a33\u5b9a\u6027\u548c\u4eb2\u548c\u529b\u3002 \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u6839\u672c\u6027\u7684\u7a33\u5b9a\u6027\u95ee\u9898\uff0c\u4e1a\u754c\u5f00\u53d1\u4e86\u591a\u79cd\u521b\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002\u6bd4\u5982\uff0c\u975e\u5929\u7136\u6c28\u57fa\u9178\u7684\u5e94\u7528\u3002\u7ef4\u4e9a\u751f\u7269\u5c0f\u5206\u5b50\u56e2\u961f\u62e5\u6709\u53ef\u9009\u62e9\u7684\u6c28\u57fa\u9178\u8d44\u6e90\uff0c\u540c\u65f6\u8ba1\u7b97\u56e2\u961f\u5efa\u7acb\u4e86\u975e\u5929\u7136\u6c28\u57fa\u9178\u5e93\uff0c\u4e3b\u8981\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff1a\u4e00\u90e8\u5206\u662f\u57fa\u4e8e\u5929\u7136\u6c28\u57fa\u9178\u884d\u751f\u7684\u7ed3\u6784\uff0c\u5360\u636e\u7c7b\u4f3c\u7684\u5316\u5b66\u7a7a\u95f4\u4f46\u5177\u6709\u66f4\u5f3a\u7684\u5316\u5b66\u591a\u6837\u6027\uff1b\u53e6\u4e00\u90e8\u5206\u5219\u662f\u4eceFDA\u6279\u51c6\u836f\u7269\u4e2d\u63d0\u53d6\u7684\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ed3\u6784\uff0c\u5927\u6982\u6709100\u591a\u4e2a\u3002 \u8fd9\u4e9b\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ecf\u8fc7\u5b8c\u5168\u7684\u53c2\u6570\u5316\u5904\u7406\uff0c\u5728\u65e5\u5e38\u8bbe\u8ba1\u4e2d\u53ef\u4ee5\u50cf\u5929\u7136\u6c28\u57fa\u9178\u4e00\u6837\u4f7f\u7528\uff0c\u751a\u81f3\u5728\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u4e2d\u4e5f\u6709\u5b8c\u6574\u7684\u529b\u573a\u53c2\u6570\u652f\u6301\uff0c\u53ef\u4ee5\u76f4\u63a5\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\u548c\u4eb2\u548c\u529b\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u7ef4\u4e9a\u8fd8\u62e5\u6709960\u4e2a\u7247\u6bb5\u5316\u5408\u7269\u5e93\uff0c\u4e0d\u4ec5\u7528\u4e8e\u6676\u4f53\u6d78\u6ce1\u5b9e\u9a8c\uff0c\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u5bfb\u627e\u751f\u7269\u7535\u5b50\u7b49\u6392\u4f53\u7684\u91cd\u8981\u8d44\u6e90\u3002 \u9488\u5bf9\u4e3b\u94fe\uff0c\u8ba1\u7b97\u56e2\u961f\u4e5f\u6709\u4e00\u7cfb\u5217\u6539\u9020\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u6c2e\u7532\u57fa\u5316\u548c\u5bf9\u5929\u7136\u80bd\u952e\u7684\u6742\u73af\u5f15\u5165\u7b49\u3002 &#8220;AI+&#8221;\u73af\u80bd\u5408\u6210\u7b56\u7565 \u5728\u89e3\u51b3\u7a33\u5b9a\u6027\u95ee\u9898\u7684\u4f17\u591a\u7b56\u7565\u4e2d\uff0c\u73af\u80bd\u6280\u672f\u5c55\u73b0\u51fa\u4e86\u72ec\u7279\u7684\u4f18\u52bf\u3002\u76f8\u6bd4\u7ebf\u6027\u80bd\uff0c\u73af\u80bd\u4e0d\u4ec5\u7a33\u5b9a\u6027\u66f4\u597d\uff0c\u4eb2\u548c\u529b\u4e5f\u66f4\u5f3a\uff0c\u900f\u819c\u6027\u4e5f\u66f4\u4f73\u3002\u7ef4\u4e9a\u751f\u7269\u5728\u73af\u80bd\u5408\u6210\u65b9\u9762\u79ef\u7d2f\u4e86\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u5df2\u5408\u6210\u8d85\u8fc73000\u6761\u591a\u80bd\uff0c\u5176\u4e2d\u73af\u80bd\u536080%\u4ee5\u4e0a\u3002 \u7ef4\u4e9a\u751f\u7269\u5177\u5907\u591a\u79cd\u6210\u73af\u5316\u5b66\u7b56\u7565\uff0c\u5176\u4e2d\u4e8c\u786b\u952e\u6210\u73af\u662f\u6700\u5e38\u89c1\u7684\u65b9\u5f0f\u3002\u57fa\u4e8e\u5def\u57fa\u7684\u53cd\u5e94\u5305\u62ec\u4e8c\u786b\u952e\u3001\u5def\u919a\u952e\u3001\u53d8\u5def\u919a\u952e\u3001\u6742\u73af\u7684SNAr\u53cd\u5e94\u3001\u7532\u5def\u54aa\u5511\u53cd\u5e94\uff0c\u4ee5\u53ca\u53cc\u952e\u7684\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u9170\u80fa\u952e\u6210\u73af\uff08\u5305\u62ec\u9996\u5c3e\u76f8\u8fde\u548c\u4fa7\u94fe\u6210\u73af\uff09\u3001Click\u5316\u5b66\u53cd\u5e94\u3001\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u7b49\u4e5f\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002 \u53cc\u73af\u80bd\u7684\u5408\u6210\u66f4\u5177\u6311\u6218\u6027\uff0c\u4e0d\u540c\u73af\u5316\u7c7b\u578b\u7684\u7ec4\u5408\u5f62\u6210\u590d\u6742\u7684\u53cc\u73af\u7ed3\u6784\u3002\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5373\u4f7f\u662f\u7b80\u5355\u7684\u4e8c\u786b\u952e\u73af\u80bd\uff0c\u4e5f\u53ef\u80fd\u51fa\u73b0\u6c28\u57fa\u9178\u6d88\u65cb\u7b49\u6280\u672f\u95ee\u9898\uff0c\u9700\u8981\u91c7\u7528\u7279\u6b8a\u7684\u5076\u8054\u65b9\u5f0f\u6765\u6291\u5236\u6d88\u65cb\uff0c\u786e\u4fdd\u4ea7\u54c1\u8d28\u91cf\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u4e0e\u5b9e\u9a8c\u5b9e\u73b0\u4e86\u5f88\u597d\u7684\u8054\u52a8\u3002\u4ee5\u4e8c\u786b\u952e\u6210\u73af\u4e3a\u4f8b\uff0c\u8ba1\u7b97\u56e2\u961f\u4f1a\u5728\u6c28\u57fa\u9178\u4e0a\u8fdb\u884c\u534a\u80f1\u6c28\u9178\u7a81\u53d8\uff0c\u5e76\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\uff0c\u89c2\u5bdf\u8fd9\u4e24\u4e2a\u7a81\u53d8\u4f4d\u70b9\u5728\u6784\u8c61\u7a7a\u95f4\u4e2d\u7684\u8ddd\u79bb\u548c\u89d2\u5ea6\u5173\u7cfb\u4ee5\u53ca\u4e3b\u8981\u5206\u5e03\u3002\u6709\u4e86\u8fd9\u4e9b\u4fe1\u606f\uff0c\u5c31\u53ef\u4ee5\u4e0e\u5df2\u6709\u7684\u6210\u73af\u65b9\u5f0f\u8fdb\u884c\u5339\u914d\uff0c\u627e\u5230\u6700\u9002\u5408\u7684\u6210\u73af\u7b56\u7565\u3002\u8fd9\u79cd\u65b9\u6cd5\u540c\u6837\u9002\u7528\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u6210\u73af\u53cd\u5e94\uff0c\u53ea\u9700\u8981\u5c06\u7a81\u53d8\u7684\u6c28\u57fa\u9178\u6362\u6210\u4e19\u6c28\u9178\u6216\u5e26\u6709\u7279\u5b9a\u4fa7\u94fe\u7684\u6c28\u57fa\u9178\u5373\u53ef\u3002 \u5bf9\u4e8e\u66f4\u590d\u6742\u7684\u60c5\u51b5\uff0c\u6bd4\u5982\u4ece\u5934\u8bbe\u8ba1\u73af\u80bd\u65f6\uff0c\u53ef\u4ee5\u4f7f\u7528Rosetta-KIC\uff08Kinetic Loop Modeling\uff09\u7b49\u7ecf\u5178\u65b9\u6cd5\u6765\u627e\u51fa\u7f3a\u5931\u7684\u6c28\u57fa\u9178\u3002\u627e\u5230\u5019\u9009\u5e8f\u5217\u540e\uff0c\u8fd8\u9700\u8981\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u7ed3\u6784\u4f18\u5316\uff0c\u5305\u62ec\u5728\u975e\u7ed3\u5408\u7684\u6eb6\u6db2\u73af\u5883\u4e2d\u8fdb\u884c\u91c7\u6837\uff0c\u8ba1\u7b97\u5e94\u53d8\u80fd\uff08strain energy\uff09\u6765\u8bc4\u4f30\u6210\u73af\u7684\u96be\u6613\u7a0b\u5ea6\u3002 \u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u4f1a\u6bd4\u8f83\u672a\u7ed3\u5408\u72b6\u6001\u4e0e\u590d\u5408\u7269\u7ed3\u6784\u7684\u6784\u8c61\u76f8\u4f3c\u6027\uff0c\u786e\u4fdd\u6700\u7ec8\u7684\u73af\u80bd\u5c3d\u53ef\u80fd\u63a5\u8fd1\u751f\u7269\u6d3b\u6027\u6784\u8c61\u3002\u8fd9\u79cd\u5bf9\u6784\u8c61\u5dee\u5f02\u7684\u5173\u6ce8\uff0c\u80fd\u591f\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u71b5\u60e9\u7f5a\uff0c\u4ece\u800c\u63d0\u9ad8\u591a\u80bd\u7684\u4eb2\u548c\u529b\u548c\u5176\u4ed6\u5173\u952e\u6027\u8d28\u3002 MK-0616\u8bbe\u8ba1\u7cbe\u9ad3\u2014\u2014\u7ed3\u6784\u9a71\u52a8\u7684\u836f\u5316\u8bbe\u8ba1 MK-0616\u4f5c\u4e3a\u9776\u5411PCSK9\u7684\u53e3\u670d\u591a\u80bd\u836f\u7269\uff0c\u8d70\u5728\u4e86\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u7684\u524d\u6cbf\u3002PCSK9\u5bf9\u4e8e\u7ef4\u4e9a\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u719f\u6089\u7684\u9776\u70b9\uff1a\u66fe\u6df1\u5ea6\u53c2\u4e0ePCSK9\u5c0f\u5206\u5b50\u7684\u836f\u7269\u7814\u53d1\uff0c\u76ee\u524d\u8be5\u9879\u76ee\u5df2\u7ecf\u8fdb\u5165\u5230\u4e09\u671f\u9636\u6bb5\u3002 MK-0616\u6700\u521d\u662f\u4ecemRNA\u7b5b\u9009\u4e2d\u5f97\u5230\u7684\u5355\u73af\u73af\u80bd\uff0c\u540e\u6765\u7814\u53d1\u4eba\u5458\u5c06\u5176\u6539\u9020\u6210\u4e09\u73af\u80bd\uff0c\u4eb2\u548c\u529b\u6709\u4e86\u663e\u8457\u63d0\u9ad8\u3002\u4ece\u5408\u6210\u5316\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u4e2a\u5206\u5b50\u7684\u5408\u6210\u96be\u5ea6\u6781\u9ad8\uff0c\u8be5\u5168\u5408\u6210\u5de5\u4f5c\u4e8e2025\u5e74\u53d1\u8868\u5728JACS\u4e0a\u3002 \u4ece\u590d\u5408\u7269\u7ed3\u6784\u6765\u770b\uff0c\u52a0\u5165\u7b2c\u4e09\u4e2a\u73af\u540e\u7684\u6676\u4f53\u7ed3\u6784\u4e0e\u53ea\u6709\u4e24\u4e2a\u73af\u65f6\u7684\u7ed3\u6784\u51e0\u4e4e\u5b8c\u5168\u91cd\u53e0\uff0c\u53e0\u5408\u5f97\u975e\u5e38\u597d\u3002\u8fd9\u5c55\u73b0\u4e86\u7ed3\u6784\u751f\u7269\u5b66\u4e0e\u836f\u7269\u5316\u5b66\u7684\u5b8c\u7f8e\u878d\u5408\u3002\u800c\u7ef4\u4e9a\u751f\u7269\u81ea\u6210\u7acb\u8d77\u5c31\u6df1\u8015\u5e03\u5c40\u8fd9\u4e00\u9886\u57df\uff0c\u5e2e\u52a9\u5168\u7403\u6570\u5343\u5bb6\u5ba2\u6237\u653b\u514b\u7ed3\u6784\u751f\u7269\u5b66\u4e16\u754c\u7ea7\u96be\u9898\u3002\u622a\u81f32024\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5df2\u5411\u5168\u7403\u5ba2\u6237\u4ea4\u4ed8\u8d85\u8fc782,000+\u4f8b\u86cb\u767d\u7ed3\u6784\uff0c\u7814\u7a76\u7684\u836f\u7269\u9776\u6807\u6570\u91cf\u7d2f\u8ba1\u7a81\u78342,000\u4e2a\uff0c\u7a33\u5c45\u5168\u7403\u86cb\u767d\u7ed3\u6784\u89e3\u6790\u7684\u5236\u9ad8\u70b9\u524d\u5217\u3002 \u7ef4\u4e9a\u751f\u7269\u7684\u591a\u80bd\u63a2\u7d22\u8def\u5f84 \u7b5b\u9009\u6280\u672f\u7684\u591a\u6837\u5316\u53d1\u5c55 \u968f\u7740\u591a\u80bd\u836f\u7269\u7814\u53d1\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u7814\u53d1\u624b\u6bb5\u4e5f\u5728\u4e0d\u65ad\u8fdb\u6b65\u3002\u4ece\u5b9e\u9a8c\u4e0a\u6765\u770b\uff0c\u4f20\u7edf\u7684\u65b9\u6cd5\u6709\u566c\u83cc\u4f53\u5c55\u793a\u80bd\u5e93\uff0c\u8fd9\u4e2a\u7ef4\u4e9a\u5c31\u6709\u3002\u53e6\u5916\uff0cmRNA\u5c55\u793a\u6280\u672f\u56e0\u4e3a\u53ef\u4ee5\u5305\u542b\u5929\u7136\u548c\u975e\u5929\u7136\u6c28\u57fa\u9178\uff0c\u5728\u73af\u80bd\u5e93\u7b5b\u9009\u4e2d\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u8fd8\u6709\u4e00\u4e2a\u6bd4\u8f83\u6709\u7279\u8272\u7684\u662fDEL\u73af\u80bd\u5e93\u3002 \u7ef4\u4e9a\u751f\u7269\u5efa\u7acb\u4e86\u591a\u4ee3DEL\u73af\u80bd\u5e93\uff1a\u7b2c\u4e00\u4ee3\u7531\u4e09\u4e2abuilding blocks\u548cClick\u5316\u5b66\u5173\u73af\u53cd\u5e94\u7ec4\u6210\uff0c\u73af\u80bd\u957f\u5ea6\u57284-17\u4e2a\u6c28\u57fa\u9178\u8303\u56f4\u5185\uff1b\u5347\u7ea7\u7248\u7684DEL\u73af\u80bd\u5e93\u5305\u542b\u56db\u4e2abuilding blocks\u548c\u591a\u79cd\u5173\u73af\u53cd\u5e94\uff0c\u5355\u73af\u5206\u5b50\u5e93\u8fbe\u52305000\u4ebf\u4e2a\u5316\u5408\u7269\uff0c\u53cc\u73af\u5206\u5b50\u5e93\u4e5f\u6709500\u591a\u4ebf\u4e2a\u5316\u5408\u7269\u3002 \u5728\u8bbe\u8ba1\u8fd9\u4e9b\u5316\u5408\u7269\u5e93\u65f6\uff0c\u56e2\u961f\u7279\u522b\u6ce8\u91cd\u5173\u73af\u53cd\u5e94\u7684\u4ea7\u7387\u9009\u62e9\uff0c\u4ee5\u786e\u4fddDNA\u7b5b\u9009\u7684\u6210\u529f\u7387\u3002\u53e6\u5916\uff0c\u8ba1\u7b97\u4e0eDEL\u7684\u8054\u52a8\uff0c\u8fd8\u5305\u62ec\u4ece\u524d\u671fbuilding blocks\u7684\u9009\u53d6\uff08\u8fd9\u672c\u8eab\u5c31\u4f53\u73b0\u4e86\u4e0e\u9776\u70b9\u76f8\u5173\u7684\u4f9d\u8d56\u6027\uff09\u5230\u540e\u671f\u8fdb\u4e00\u6b65\u82d7\u5934\u5316\u5408\u7269\u7684\u5bcc\u96c6\u5206\u6790\uff0c\u90fd\u9700\u8981\u9ad8\u7cbe\u5ea6\u7684\u8ba1\u7b97\u652f\u6301\uff0c\u4ece\u800c\u4e3a\u540e\u7eed\u7684\u5316\u5408\u7269\u6539\u9020\u548c\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002 \u4ece\u5934\u8bbe\u8ba1\u7684AI\u65b0\u601d\u8def \u9664\u4e86\u7b5b\u9009\u4ee5\u5916\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u8fd8\u62e5\u6709\u4e00\u6574\u5957\u4ece\u5934\u8bbe\u8ba1\u7684\u65b9\u6cd5\uff0c\u4e3b\u8981\u5206\u4e3a\u4e09\u7c7b\uff1a\u57fa\u4e8e\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u7684\u8bbe\u8ba1\u3001\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4ee5\u53ca\u5b8c\u5168\u57fa\u4e8eAI\u7684\u4ece\u5934\u751f\u6210\u3002 \u73af\u80bd\u4f5c\u4e3aPPI\u5e72\u6270\u5242\u5177\u6709\u72ec\u7279\u4f18\u52bf\uff0c\u4ee5\u4e34\u5e8a\u4e09\u671f\u7684JNJ-2113\u4e3a\u4f8b\uff0c\u7ef4\u4e9a\u901a\u8fc7\u590d\u5408\u7269\u7ed3\u6784\u5efa\u6a21\u53d1\u73b0\uff0c\u5176\u7ed3\u5408\u7684\u591a\u80bd\u7247\u6bb5\u4e0e\u539fIL-23 P19\u86cb\u767d\u5728\u76f8\u540c\u4f4d\u7f6e\u5177\u6709\u663e\u8457\u76f8\u4f3c\u6027\uff0c\u7279\u522b\u662f\u4fdd\u5b88\u7684\u8272\u6c28\u9178\uff08Tryptophan\uff09\u7ed3\u6784\u5360\u636e\u4e86\u76f8\u4f3c\u7684\u4f4d\u7f6e\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u4e2a\u591a\u80bd\u6700\u521d\u4e5f\u662f\u901a\u8fc7\u566c\u83cc\u4f53\u5c55\u793a\u7b5b\u9009\u5f97\u5230\u7684\uff0c\u5448\u73b0\u51fa\u4e00\u79cd\u6b8a\u9014\u540c\u5f52\u7684\u6548\u679c\u3002 \u7c7b\u4f3c\u7684\u662f\uff0c\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4e5f\u6d89\u53ca\u5230\u4e86PPI\uff0c\u672c\u8eab\u5177\u6709\u5f88\u5f3a\u7684\u6539\u9020\u7a7a\u95f4\u3002\u7ef4\u4e9a\u53ef\u4ee5\u5c06\u5355\u6297\u5207\u5272\u4e3aVHH\uff0cVHH\u53ef\u4ee5\u8fdb\u4e00\u6b65\u51cf\u5c0f\u505a\u6210\u73af\u80bd\u3002 \u8fd8\u6709\u4e00\u79cd\u5b8c\u5168\u7684\u4ece\u5934\u751f\u6210\u65b9\u5f0f\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ea\u9700\u8981\u9776\u86cb\u767d\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u505a\u5168\u65b0\u7684\u591a\u80bd\u8bbe\u8ba1\u3002\u8fd9\u4e9b\u65b9\u6cd5\u53ef\u4ee5\u975e\u5e38\u7075\u6d3b\u5730\u4f7f\u7528\uff0c\u800c\u4e14\u540e\u671f\u8fd8\u53ef\u4ee5\u4e0e\u836f\u7269\u5316\u5b66\u56e2\u961f\u6df1\u5ea6\u5408\u4f5c\uff0c\u5728\u836f\u5316\u5c42\u9762\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4f18\u5316\u3002 \u591a\u80bd\u7814\u53d1\u7684\u65e0\u9650\u53ef\u80fd \u4ece\u4f20\u7edf\u7684\u7ebf\u6027\u80bd\u5230\u590d\u6742\u7684\u591a\u73af\u7ed3\u6784\uff0c\u4ece\u5355\u4e00\u9776\u70b9\u5230\u591a\u9776\u70b9\u534f\u540c\uff0c\u4ece\u5b9e\u9a8c\u5ba4\u7b5b\u9009\u5230AI\u9a71\u52a8\u7684\u4ece\u5934\u8bbe\u8ba1\uff0c\u6bcf\u4e00\u4e2a\u7a81\u7834\u90fd\u5728\u63a8\u52a8\u7740\u8fd9\u4e2a\u9886\u57df\u5411\u524d\u53d1\u5c55\u3002\u8fd9\u573a\u7531\u6280\u672f\u9a71\u52a8\u7684\u6d6a\u6f6e\u624d\u521a\u521a\u5f00\u59cb\uff0c\u800c\u7ef4\u4e9a\u751f\u7269\u5c06\u7ee7\u7eed\u7ad9\u5728\u8fd9\u573a\u6d6a\u6f6e\u7684\u524d\u6cbf\uff0c\u4e0e\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u4e00\u9053\uff0c\u63a2\u7d22\u591a\u80bd\u836f\u7269\u7684\u65e0\u9650\u53ef\u80fd\u3002 SOURCE \u7ef4\u4e9a\u751f\u7269\" \/>\n<meta property=\"og:url\" content=\"https:\/\/moneycompass.com.my\/cn\/\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eai\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22\/\" \/>\n<meta property=\"og:site_name\" content=\"Money Compass CN\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-23T07:33:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"144\" \/>\n\t<meta property=\"og:image:height\" content=\"51\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/\",\"name\":\"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22 - Money Compass CN\",\"isPartOf\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg\",\"datePublished\":\"2025-07-23T07:33:00+00:00\",\"dateModified\":\"2025-07-23T07:33:00+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#primaryimage\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg\",\"contentUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg\",\"width\":144,\"height\":51},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/moneycompass.com.my\/cn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/\",\"name\":\"Money Compass CN\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22 - Money Compass CN","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/moneycompass.com.my\/cn\/\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eai\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22\/","og_locale":"en_US","og_type":"article","og_title":"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22 - Money Compass CN","og_description":"\u4e0a\u6d772025\u5e747\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4ece\u53f8\u7f8e\u683c\u9c81\u80bd\u6380\u8d77\u7684&#8221;\u51cf\u80a5\u836f\u98ce\u66b4&#8221;\u5230MK-0616\u7684\u4e09\u73af\u80bd\u7a81\u7834\uff0c\u591a\u80bd\u836f\u7269\u6b63\u5728\u91cd\u65b0\u5b9a\u4e49\u751f\u7269\u533b\u836f\u7684\u8fb9\u754c\u3002\u5f53\u4e00\u4e2a60\u591a\u4e2a\u6c28\u57fa\u9178\u7684\u5206\u5b50\u53ef\u4ee5\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\uff0c\u5f53AI\u7b97\u6cd5\u80fd\u591f\u7cbe\u51c6\u9884\u6d4b\u6210\u73af\u7b56\u7565\u7684\u53ef\u884c\u6027&#8230;&#8230;\u8fd9\u4e0d\u4ec5\u4ec5\u662f\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u66f4\u662f\u4e00\u573a\u5173\u4e8e\u672a\u6765\u836f\u7269\u8bbe\u8ba1\u7684\u53d8\u5c40\u3002 \u7ef4\u4e9a\u751f\u7269\u4f5c\u4e3a\u8fd9\u573a\u53d8\u5c40\u7684\u89c1\u8bc1\u8005\u548c\u63a8\u52a8\u8005\uff0c\u63d0\u4f9b\u4ece\u591a\u80bd\u7b5b\u9009\u5230PCC\u7684\u4e00\u4f53\u5316\u7814\u53d1\u670d\u52a1\u3002\u5728\u6700\u65b0\u63a8\u51fa\u7684\u7ef4\u4e9a\u533b\u836f\u89c2\u7cfb\u5217\u4e4b\u300a\u6df1\u5ea6\u5bf9\u8bdd\u4e28\u591a\u80bd\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u8def\u5f84\u63a2\u6790\u300b\u76f4\u64ad\u4e2d\uff0c\u7ef4\u4e9a\u5256\u6790\u4e86\u591a\u4e2a\u7a81\u7834\u6027\u6848\u4f8b\u80cc\u540e\u7684\u6280\u672f\u5bc6\u7801\uff0c\u5e76\u7ed3\u5408\u81ea\u8eab\u6210\u529f\u5b9e\u8df5\uff0c\u4e3a\u4e1a\u754c\u540c\u4ec1\u63d0\u4f9b\u72ec\u5bb6\u7684\u521b\u65b0\u89c6\u89d2\u3002\u9519\u8fc7\u672c\u671f\u76f4\u64ad\u7684\u670b\u53cb\uff0c\u53ef\u4ee5\u5173\u6ce8\u7ef4\u4e9a\u751f\u7269\u300c\u89c6\u9891\u53f7\u300d\u89c2\u770b\u7cbe\u5f69\u56de\u653e\u3002 \u957f\u6548\u5316\u3001\u591a\u9776\u70b9\u8bbe\u8ba1\u7684\u65b0\u8d8b\u52bf \u591a\u80bd\u836f\u7269\u6b63\u671d\u7740\u957f\u6548\u5316\u548c\u591a\u9776\u70b9\u65b9\u5411\u53d1\u5c55\uff0c\u8fd9\u4e00\u8d8b\u52bf\u5728\u6700\u65b0\u7684\u7814\u53d1\u4e2d\u8868\u73b0\u5f97\u5c24\u4e3a\u660e\u663e\u3002\u867d\u7136\u53f8\u7f8e\u683c\u9c81\u80bd\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u4e5f\u53d1\u73b0\u4e86\u4e00\u4e2a\u95ee\u9898\u2014\u2014\u5728\u51cf\u80a5\u8fc7\u7a0b\u4e2d\u808c\u8089\u6d41\u5931\u6bd4\u4f8b\u7ea640%\uff0c\u9ad8\u4e8e\u6b63\u5e38\u8282\u98df\u953b\u70bc\u768425%\u3002\u8fd9\u79cd\u975e\u8102\u80aa\u7ec4\u7ec7\u7684\u6d41\u5931\u5bf9\u8001\u5e74\u4eba\u5f71\u54cd\u66f4\u5927\uff0c\u56e0\u4e3a\u808c\u8089\u4e00\u65e6\u6d41\u5931\u5f88\u96be\u8865\u56de\u6765\u3002 \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u53d1\u4eba\u5458\u6295\u5165\u5927\u91cf\u7cbe\u529b\u63a2\u7d22Amylin\u548cCalcitonin\u9776\u70b9\u3002\u7531\u4e8e\u8fd9\u4e9b\u9776\u70b9\u90fd\u5177\u6709\u03b1\u87ba\u65cb\u7ed3\u6784\uff0c\u4e3a\u8fde\u7528\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u901a\u8fc7\u5c06GLP-1\u548cAmylin\u591a\u80bd\u901a\u8fc7\u8fde\u63a5\u5b50\uff08Linker\uff09\u76f8\u8fde\uff0c\u518d\u8fde\u63a5\u534a\u8870\u671f\u5ef6\u957f\u57fa\u56e2\uff0c\u53ef\u5f62\u6210\u7ea660\u4e2a\u6c28\u57fa\u9178\u7684\u53cc\u91cd\u6fc0\u52a8\u5242\u3002\u66f4\u8fdb\u4e00\u6b65\uff0c2024\u5e74Pep2Tango\u516c\u53f8\u53d1\u8868\u4e13\u5229\uff0c\u5c06\u4e24\u8fb9\u90fd\u505a\u6210\u53cc\u91cd\u6fc0\u52a8\u5242\u518d\u8fde\u63a5\uff0c\u5b9e\u73b0\u4e86\u540c\u65f6\u9776\u54114\u4e2a\u9776\u70b9\u7684\u591a\u91cd\u6fc0\u52a8\u5242\u8bbe\u8ba1\u3002 \u7a33\u5b9a\u6027\u5927\u4f5c\u6218 \u591a\u80bd\u836f\u7269\u6700\u5927\u7684\u6311\u6218\u5728\u4e8e\u7a33\u5b9a\u6027\u95ee\u9898\u2014\u2014\u7531\u4e8e\u5206\u5b50\u91cf\u8f83\u5c0f\uff0c\u5bb9\u6613\u88ab\u80be\u810f\u4ee3\u8c22\u6e05\u9664\uff0c\u540c\u65f6\u7a33\u5b9a\u6027\u5dee\uff0c\u5bb9\u6613\u88ab\u4f53\u5185\u5404\u79cd\u9176\u5206\u89e3\u3002\u5929\u7136\u7684GLP-1\u534a\u8870\u671f\u53ea\u6709\u51e0\u5206\u949f\uff0c\u6839\u672c\u65e0\u6cd5\u76f4\u63a5\u6210\u836f\u3002 \u7a81\u7834\u6765\u81ea\u4e8e\u5de7\u5999\u7684\u5316\u5b66\u4fee\u9970\u7b56\u7565\u3002\u5229\u62c9\u9c81\u80bd\u7684\u7814\u53d1\u4eba\u5458\u5728\u539f\u80bd\u57fa\u7840\u4e0a\u589e\u52a0\u4e86\u4e00\u4e2a\u542bC16\u8102\u80aa\u94fe\u7684\u4fa7\u94fe\uff0c\u8fd9\u4e2a\u4fa7\u94fe\u53ef\u4ee5\u4e0e\u8840\u6e05\u4e2d\u7684\u767d\u86cb\u767d\u8fdb\u884c\u53ef\u9006\u7ed3\u5408\u3002\u901a\u8fc7\u4e0e\u5927\u5206\u5b50\u767d\u86cb\u767d\u7ed3\u5408\uff0c\u5927\u5927\u5ef6\u957f\u4e86\u534a\u8870\u671f\uff0c\u5b9e\u73b0\u4e86\u6bcf\u65e5\u7ed9\u836f\u4e00\u6b21\u7684\u76ee\u6807\u3002\u53f8\u7f8e\u683c\u9c81\u80bd\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u4e0d\u4ec5\u4fdd\u7559\u4e86\u8fd9\u79cd\u7b56\u7565\uff0c\u8fd8\u589e\u52a0\u4e86\u4e00\u4e9b\u6807\u7b7e\u5e8f\u5217\u7684\u6539\u8fdb\uff0c\u63d0\u9ad8\u4e86\u7a33\u5b9a\u6027\u548c\u4eb2\u548c\u529b\u3002 \u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u6839\u672c\u6027\u7684\u7a33\u5b9a\u6027\u95ee\u9898\uff0c\u4e1a\u754c\u5f00\u53d1\u4e86\u591a\u79cd\u521b\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002\u6bd4\u5982\uff0c\u975e\u5929\u7136\u6c28\u57fa\u9178\u7684\u5e94\u7528\u3002\u7ef4\u4e9a\u751f\u7269\u5c0f\u5206\u5b50\u56e2\u961f\u62e5\u6709\u53ef\u9009\u62e9\u7684\u6c28\u57fa\u9178\u8d44\u6e90\uff0c\u540c\u65f6\u8ba1\u7b97\u56e2\u961f\u5efa\u7acb\u4e86\u975e\u5929\u7136\u6c28\u57fa\u9178\u5e93\uff0c\u4e3b\u8981\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff1a\u4e00\u90e8\u5206\u662f\u57fa\u4e8e\u5929\u7136\u6c28\u57fa\u9178\u884d\u751f\u7684\u7ed3\u6784\uff0c\u5360\u636e\u7c7b\u4f3c\u7684\u5316\u5b66\u7a7a\u95f4\u4f46\u5177\u6709\u66f4\u5f3a\u7684\u5316\u5b66\u591a\u6837\u6027\uff1b\u53e6\u4e00\u90e8\u5206\u5219\u662f\u4eceFDA\u6279\u51c6\u836f\u7269\u4e2d\u63d0\u53d6\u7684\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ed3\u6784\uff0c\u5927\u6982\u6709100\u591a\u4e2a\u3002 \u8fd9\u4e9b\u975e\u5929\u7136\u6c28\u57fa\u9178\u7ecf\u8fc7\u5b8c\u5168\u7684\u53c2\u6570\u5316\u5904\u7406\uff0c\u5728\u65e5\u5e38\u8bbe\u8ba1\u4e2d\u53ef\u4ee5\u50cf\u5929\u7136\u6c28\u57fa\u9178\u4e00\u6837\u4f7f\u7528\uff0c\u751a\u81f3\u5728\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u4e2d\u4e5f\u6709\u5b8c\u6574\u7684\u529b\u573a\u53c2\u6570\u652f\u6301\uff0c\u53ef\u4ee5\u76f4\u63a5\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\u548c\u4eb2\u548c\u529b\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u7ef4\u4e9a\u8fd8\u62e5\u6709960\u4e2a\u7247\u6bb5\u5316\u5408\u7269\u5e93\uff0c\u4e0d\u4ec5\u7528\u4e8e\u6676\u4f53\u6d78\u6ce1\u5b9e\u9a8c\uff0c\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u5bfb\u627e\u751f\u7269\u7535\u5b50\u7b49\u6392\u4f53\u7684\u91cd\u8981\u8d44\u6e90\u3002 \u9488\u5bf9\u4e3b\u94fe\uff0c\u8ba1\u7b97\u56e2\u961f\u4e5f\u6709\u4e00\u7cfb\u5217\u6539\u9020\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u6c2e\u7532\u57fa\u5316\u548c\u5bf9\u5929\u7136\u80bd\u952e\u7684\u6742\u73af\u5f15\u5165\u7b49\u3002 &#8220;AI+&#8221;\u73af\u80bd\u5408\u6210\u7b56\u7565 \u5728\u89e3\u51b3\u7a33\u5b9a\u6027\u95ee\u9898\u7684\u4f17\u591a\u7b56\u7565\u4e2d\uff0c\u73af\u80bd\u6280\u672f\u5c55\u73b0\u51fa\u4e86\u72ec\u7279\u7684\u4f18\u52bf\u3002\u76f8\u6bd4\u7ebf\u6027\u80bd\uff0c\u73af\u80bd\u4e0d\u4ec5\u7a33\u5b9a\u6027\u66f4\u597d\uff0c\u4eb2\u548c\u529b\u4e5f\u66f4\u5f3a\uff0c\u900f\u819c\u6027\u4e5f\u66f4\u4f73\u3002\u7ef4\u4e9a\u751f\u7269\u5728\u73af\u80bd\u5408\u6210\u65b9\u9762\u79ef\u7d2f\u4e86\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u5df2\u5408\u6210\u8d85\u8fc73000\u6761\u591a\u80bd\uff0c\u5176\u4e2d\u73af\u80bd\u536080%\u4ee5\u4e0a\u3002 \u7ef4\u4e9a\u751f\u7269\u5177\u5907\u591a\u79cd\u6210\u73af\u5316\u5b66\u7b56\u7565\uff0c\u5176\u4e2d\u4e8c\u786b\u952e\u6210\u73af\u662f\u6700\u5e38\u89c1\u7684\u65b9\u5f0f\u3002\u57fa\u4e8e\u5def\u57fa\u7684\u53cd\u5e94\u5305\u62ec\u4e8c\u786b\u952e\u3001\u5def\u919a\u952e\u3001\u53d8\u5def\u919a\u952e\u3001\u6742\u73af\u7684SNAr\u53cd\u5e94\u3001\u7532\u5def\u54aa\u5511\u53cd\u5e94\uff0c\u4ee5\u53ca\u53cc\u952e\u7684\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u9170\u80fa\u952e\u6210\u73af\uff08\u5305\u62ec\u9996\u5c3e\u76f8\u8fde\u548c\u4fa7\u94fe\u6210\u73af\uff09\u3001Click\u5316\u5b66\u53cd\u5e94\u3001\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u7b49\u4e5f\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002 \u53cc\u73af\u80bd\u7684\u5408\u6210\u66f4\u5177\u6311\u6218\u6027\uff0c\u4e0d\u540c\u73af\u5316\u7c7b\u578b\u7684\u7ec4\u5408\u5f62\u6210\u590d\u6742\u7684\u53cc\u73af\u7ed3\u6784\u3002\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5373\u4f7f\u662f\u7b80\u5355\u7684\u4e8c\u786b\u952e\u73af\u80bd\uff0c\u4e5f\u53ef\u80fd\u51fa\u73b0\u6c28\u57fa\u9178\u6d88\u65cb\u7b49\u6280\u672f\u95ee\u9898\uff0c\u9700\u8981\u91c7\u7528\u7279\u6b8a\u7684\u5076\u8054\u65b9\u5f0f\u6765\u6291\u5236\u6d88\u65cb\uff0c\u786e\u4fdd\u4ea7\u54c1\u8d28\u91cf\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u4e0e\u5b9e\u9a8c\u5b9e\u73b0\u4e86\u5f88\u597d\u7684\u8054\u52a8\u3002\u4ee5\u4e8c\u786b\u952e\u6210\u73af\u4e3a\u4f8b\uff0c\u8ba1\u7b97\u56e2\u961f\u4f1a\u5728\u6c28\u57fa\u9178\u4e0a\u8fdb\u884c\u534a\u80f1\u6c28\u9178\u7a81\u53d8\uff0c\u5e76\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u91c7\u6837\uff0c\u89c2\u5bdf\u8fd9\u4e24\u4e2a\u7a81\u53d8\u4f4d\u70b9\u5728\u6784\u8c61\u7a7a\u95f4\u4e2d\u7684\u8ddd\u79bb\u548c\u89d2\u5ea6\u5173\u7cfb\u4ee5\u53ca\u4e3b\u8981\u5206\u5e03\u3002\u6709\u4e86\u8fd9\u4e9b\u4fe1\u606f\uff0c\u5c31\u53ef\u4ee5\u4e0e\u5df2\u6709\u7684\u6210\u73af\u65b9\u5f0f\u8fdb\u884c\u5339\u914d\uff0c\u627e\u5230\u6700\u9002\u5408\u7684\u6210\u73af\u7b56\u7565\u3002\u8fd9\u79cd\u65b9\u6cd5\u540c\u6837\u9002\u7528\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u6210\u73af\u53cd\u5e94\uff0c\u53ea\u9700\u8981\u5c06\u7a81\u53d8\u7684\u6c28\u57fa\u9178\u6362\u6210\u4e19\u6c28\u9178\u6216\u5e26\u6709\u7279\u5b9a\u4fa7\u94fe\u7684\u6c28\u57fa\u9178\u5373\u53ef\u3002 \u5bf9\u4e8e\u66f4\u590d\u6742\u7684\u60c5\u51b5\uff0c\u6bd4\u5982\u4ece\u5934\u8bbe\u8ba1\u73af\u80bd\u65f6\uff0c\u53ef\u4ee5\u4f7f\u7528Rosetta-KIC\uff08Kinetic Loop Modeling\uff09\u7b49\u7ecf\u5178\u65b9\u6cd5\u6765\u627e\u51fa\u7f3a\u5931\u7684\u6c28\u57fa\u9178\u3002\u627e\u5230\u5019\u9009\u5e8f\u5217\u540e\uff0c\u8fd8\u9700\u8981\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u7ed3\u6784\u4f18\u5316\uff0c\u5305\u62ec\u5728\u975e\u7ed3\u5408\u7684\u6eb6\u6db2\u73af\u5883\u4e2d\u8fdb\u884c\u91c7\u6837\uff0c\u8ba1\u7b97\u5e94\u53d8\u80fd\uff08strain energy\uff09\u6765\u8bc4\u4f30\u6210\u73af\u7684\u96be\u6613\u7a0b\u5ea6\u3002 \u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u4f1a\u6bd4\u8f83\u672a\u7ed3\u5408\u72b6\u6001\u4e0e\u590d\u5408\u7269\u7ed3\u6784\u7684\u6784\u8c61\u76f8\u4f3c\u6027\uff0c\u786e\u4fdd\u6700\u7ec8\u7684\u73af\u80bd\u5c3d\u53ef\u80fd\u63a5\u8fd1\u751f\u7269\u6d3b\u6027\u6784\u8c61\u3002\u8fd9\u79cd\u5bf9\u6784\u8c61\u5dee\u5f02\u7684\u5173\u6ce8\uff0c\u80fd\u591f\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u71b5\u60e9\u7f5a\uff0c\u4ece\u800c\u63d0\u9ad8\u591a\u80bd\u7684\u4eb2\u548c\u529b\u548c\u5176\u4ed6\u5173\u952e\u6027\u8d28\u3002 MK-0616\u8bbe\u8ba1\u7cbe\u9ad3\u2014\u2014\u7ed3\u6784\u9a71\u52a8\u7684\u836f\u5316\u8bbe\u8ba1 MK-0616\u4f5c\u4e3a\u9776\u5411PCSK9\u7684\u53e3\u670d\u591a\u80bd\u836f\u7269\uff0c\u8d70\u5728\u4e86\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u7684\u524d\u6cbf\u3002PCSK9\u5bf9\u4e8e\u7ef4\u4e9a\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u719f\u6089\u7684\u9776\u70b9\uff1a\u66fe\u6df1\u5ea6\u53c2\u4e0ePCSK9\u5c0f\u5206\u5b50\u7684\u836f\u7269\u7814\u53d1\uff0c\u76ee\u524d\u8be5\u9879\u76ee\u5df2\u7ecf\u8fdb\u5165\u5230\u4e09\u671f\u9636\u6bb5\u3002 MK-0616\u6700\u521d\u662f\u4ecemRNA\u7b5b\u9009\u4e2d\u5f97\u5230\u7684\u5355\u73af\u73af\u80bd\uff0c\u540e\u6765\u7814\u53d1\u4eba\u5458\u5c06\u5176\u6539\u9020\u6210\u4e09\u73af\u80bd\uff0c\u4eb2\u548c\u529b\u6709\u4e86\u663e\u8457\u63d0\u9ad8\u3002\u4ece\u5408\u6210\u5316\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u4e2a\u5206\u5b50\u7684\u5408\u6210\u96be\u5ea6\u6781\u9ad8\uff0c\u8be5\u5168\u5408\u6210\u5de5\u4f5c\u4e8e2025\u5e74\u53d1\u8868\u5728JACS\u4e0a\u3002 \u4ece\u590d\u5408\u7269\u7ed3\u6784\u6765\u770b\uff0c\u52a0\u5165\u7b2c\u4e09\u4e2a\u73af\u540e\u7684\u6676\u4f53\u7ed3\u6784\u4e0e\u53ea\u6709\u4e24\u4e2a\u73af\u65f6\u7684\u7ed3\u6784\u51e0\u4e4e\u5b8c\u5168\u91cd\u53e0\uff0c\u53e0\u5408\u5f97\u975e\u5e38\u597d\u3002\u8fd9\u5c55\u73b0\u4e86\u7ed3\u6784\u751f\u7269\u5b66\u4e0e\u836f\u7269\u5316\u5b66\u7684\u5b8c\u7f8e\u878d\u5408\u3002\u800c\u7ef4\u4e9a\u751f\u7269\u81ea\u6210\u7acb\u8d77\u5c31\u6df1\u8015\u5e03\u5c40\u8fd9\u4e00\u9886\u57df\uff0c\u5e2e\u52a9\u5168\u7403\u6570\u5343\u5bb6\u5ba2\u6237\u653b\u514b\u7ed3\u6784\u751f\u7269\u5b66\u4e16\u754c\u7ea7\u96be\u9898\u3002\u622a\u81f32024\u5e7412\u670831\u65e5\uff0c\u516c\u53f8\u5df2\u5411\u5168\u7403\u5ba2\u6237\u4ea4\u4ed8\u8d85\u8fc782,000+\u4f8b\u86cb\u767d\u7ed3\u6784\uff0c\u7814\u7a76\u7684\u836f\u7269\u9776\u6807\u6570\u91cf\u7d2f\u8ba1\u7a81\u78342,000\u4e2a\uff0c\u7a33\u5c45\u5168\u7403\u86cb\u767d\u7ed3\u6784\u89e3\u6790\u7684\u5236\u9ad8\u70b9\u524d\u5217\u3002 \u7ef4\u4e9a\u751f\u7269\u7684\u591a\u80bd\u63a2\u7d22\u8def\u5f84 \u7b5b\u9009\u6280\u672f\u7684\u591a\u6837\u5316\u53d1\u5c55 \u968f\u7740\u591a\u80bd\u836f\u7269\u7814\u53d1\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u7814\u53d1\u624b\u6bb5\u4e5f\u5728\u4e0d\u65ad\u8fdb\u6b65\u3002\u4ece\u5b9e\u9a8c\u4e0a\u6765\u770b\uff0c\u4f20\u7edf\u7684\u65b9\u6cd5\u6709\u566c\u83cc\u4f53\u5c55\u793a\u80bd\u5e93\uff0c\u8fd9\u4e2a\u7ef4\u4e9a\u5c31\u6709\u3002\u53e6\u5916\uff0cmRNA\u5c55\u793a\u6280\u672f\u56e0\u4e3a\u53ef\u4ee5\u5305\u542b\u5929\u7136\u548c\u975e\u5929\u7136\u6c28\u57fa\u9178\uff0c\u5728\u73af\u80bd\u5e93\u7b5b\u9009\u4e2d\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u8fd8\u6709\u4e00\u4e2a\u6bd4\u8f83\u6709\u7279\u8272\u7684\u662fDEL\u73af\u80bd\u5e93\u3002 \u7ef4\u4e9a\u751f\u7269\u5efa\u7acb\u4e86\u591a\u4ee3DEL\u73af\u80bd\u5e93\uff1a\u7b2c\u4e00\u4ee3\u7531\u4e09\u4e2abuilding blocks\u548cClick\u5316\u5b66\u5173\u73af\u53cd\u5e94\u7ec4\u6210\uff0c\u73af\u80bd\u957f\u5ea6\u57284-17\u4e2a\u6c28\u57fa\u9178\u8303\u56f4\u5185\uff1b\u5347\u7ea7\u7248\u7684DEL\u73af\u80bd\u5e93\u5305\u542b\u56db\u4e2abuilding blocks\u548c\u591a\u79cd\u5173\u73af\u53cd\u5e94\uff0c\u5355\u73af\u5206\u5b50\u5e93\u8fbe\u52305000\u4ebf\u4e2a\u5316\u5408\u7269\uff0c\u53cc\u73af\u5206\u5b50\u5e93\u4e5f\u6709500\u591a\u4ebf\u4e2a\u5316\u5408\u7269\u3002 \u5728\u8bbe\u8ba1\u8fd9\u4e9b\u5316\u5408\u7269\u5e93\u65f6\uff0c\u56e2\u961f\u7279\u522b\u6ce8\u91cd\u5173\u73af\u53cd\u5e94\u7684\u4ea7\u7387\u9009\u62e9\uff0c\u4ee5\u786e\u4fddDNA\u7b5b\u9009\u7684\u6210\u529f\u7387\u3002\u53e6\u5916\uff0c\u8ba1\u7b97\u4e0eDEL\u7684\u8054\u52a8\uff0c\u8fd8\u5305\u62ec\u4ece\u524d\u671fbuilding blocks\u7684\u9009\u53d6\uff08\u8fd9\u672c\u8eab\u5c31\u4f53\u73b0\u4e86\u4e0e\u9776\u70b9\u76f8\u5173\u7684\u4f9d\u8d56\u6027\uff09\u5230\u540e\u671f\u8fdb\u4e00\u6b65\u82d7\u5934\u5316\u5408\u7269\u7684\u5bcc\u96c6\u5206\u6790\uff0c\u90fd\u9700\u8981\u9ad8\u7cbe\u5ea6\u7684\u8ba1\u7b97\u652f\u6301\uff0c\u4ece\u800c\u4e3a\u540e\u7eed\u7684\u5316\u5408\u7269\u6539\u9020\u548c\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002 \u4ece\u5934\u8bbe\u8ba1\u7684AI\u65b0\u601d\u8def \u9664\u4e86\u7b5b\u9009\u4ee5\u5916\uff0c\u7ef4\u4e9a\u8ba1\u7b97\u56e2\u961f\u8fd8\u62e5\u6709\u4e00\u6574\u5957\u4ece\u5934\u8bbe\u8ba1\u7684\u65b9\u6cd5\uff0c\u4e3b\u8981\u5206\u4e3a\u4e09\u7c7b\uff1a\u57fa\u4e8e\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u7684\u8bbe\u8ba1\u3001\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4ee5\u53ca\u5b8c\u5168\u57fa\u4e8eAI\u7684\u4ece\u5934\u751f\u6210\u3002 \u73af\u80bd\u4f5c\u4e3aPPI\u5e72\u6270\u5242\u5177\u6709\u72ec\u7279\u4f18\u52bf\uff0c\u4ee5\u4e34\u5e8a\u4e09\u671f\u7684JNJ-2113\u4e3a\u4f8b\uff0c\u7ef4\u4e9a\u901a\u8fc7\u590d\u5408\u7269\u7ed3\u6784\u5efa\u6a21\u53d1\u73b0\uff0c\u5176\u7ed3\u5408\u7684\u591a\u80bd\u7247\u6bb5\u4e0e\u539fIL-23 P19\u86cb\u767d\u5728\u76f8\u540c\u4f4d\u7f6e\u5177\u6709\u663e\u8457\u76f8\u4f3c\u6027\uff0c\u7279\u522b\u662f\u4fdd\u5b88\u7684\u8272\u6c28\u9178\uff08Tryptophan\uff09\u7ed3\u6784\u5360\u636e\u4e86\u76f8\u4f3c\u7684\u4f4d\u7f6e\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u4e2a\u591a\u80bd\u6700\u521d\u4e5f\u662f\u901a\u8fc7\u566c\u83cc\u4f53\u5c55\u793a\u7b5b\u9009\u5f97\u5230\u7684\uff0c\u5448\u73b0\u51fa\u4e00\u79cd\u6b8a\u9014\u540c\u5f52\u7684\u6548\u679c\u3002 \u7c7b\u4f3c\u7684\u662f\uff0c\u4ee5\u6297\u4f53\u4e3a\u8d77\u70b9\u7684\u8bbe\u8ba1\uff0c\u4e5f\u6d89\u53ca\u5230\u4e86PPI\uff0c\u672c\u8eab\u5177\u6709\u5f88\u5f3a\u7684\u6539\u9020\u7a7a\u95f4\u3002\u7ef4\u4e9a\u53ef\u4ee5\u5c06\u5355\u6297\u5207\u5272\u4e3aVHH\uff0cVHH\u53ef\u4ee5\u8fdb\u4e00\u6b65\u51cf\u5c0f\u505a\u6210\u73af\u80bd\u3002 \u8fd8\u6709\u4e00\u79cd\u5b8c\u5168\u7684\u4ece\u5934\u751f\u6210\u65b9\u5f0f\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ea\u9700\u8981\u9776\u86cb\u767d\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u505a\u5168\u65b0\u7684\u591a\u80bd\u8bbe\u8ba1\u3002\u8fd9\u4e9b\u65b9\u6cd5\u53ef\u4ee5\u975e\u5e38\u7075\u6d3b\u5730\u4f7f\u7528\uff0c\u800c\u4e14\u540e\u671f\u8fd8\u53ef\u4ee5\u4e0e\u836f\u7269\u5316\u5b66\u56e2\u961f\u6df1\u5ea6\u5408\u4f5c\uff0c\u5728\u836f\u5316\u5c42\u9762\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4f18\u5316\u3002 \u591a\u80bd\u7814\u53d1\u7684\u65e0\u9650\u53ef\u80fd \u4ece\u4f20\u7edf\u7684\u7ebf\u6027\u80bd\u5230\u590d\u6742\u7684\u591a\u73af\u7ed3\u6784\uff0c\u4ece\u5355\u4e00\u9776\u70b9\u5230\u591a\u9776\u70b9\u534f\u540c\uff0c\u4ece\u5b9e\u9a8c\u5ba4\u7b5b\u9009\u5230AI\u9a71\u52a8\u7684\u4ece\u5934\u8bbe\u8ba1\uff0c\u6bcf\u4e00\u4e2a\u7a81\u7834\u90fd\u5728\u63a8\u52a8\u7740\u8fd9\u4e2a\u9886\u57df\u5411\u524d\u53d1\u5c55\u3002\u8fd9\u573a\u7531\u6280\u672f\u9a71\u52a8\u7684\u6d6a\u6f6e\u624d\u521a\u521a\u5f00\u59cb\uff0c\u800c\u7ef4\u4e9a\u751f\u7269\u5c06\u7ee7\u7eed\u7ad9\u5728\u8fd9\u573a\u6d6a\u6f6e\u7684\u524d\u6cbf\uff0c\u4e0e\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u4e00\u9053\uff0c\u63a2\u7d22\u591a\u80bd\u836f\u7269\u7684\u65e0\u9650\u53ef\u80fd\u3002 SOURCE \u7ef4\u4e9a\u751f\u7269","og_url":"https:\/\/moneycompass.com.my\/cn\/\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eai\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22\/","og_site_name":"Money Compass CN","article_published_time":"2025-07-23T07:33:00+00:00","og_image":[{"width":144,"height":51,"url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/","url":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/","name":"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22 - Money Compass CN","isPartOf":{"@id":"https:\/\/moneycompass.com.my\/cn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#primaryimage"},"image":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#primaryimage"},"thumbnailUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg","datePublished":"2025-07-23T07:33:00+00:00","dateModified":"2025-07-23T07:33:00+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#primaryimage","url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg","contentUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/07\/image_5016940_33517010-spjsJw.jpeg","width":144,"height":51},{"@type":"BreadcrumbList","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%a4%9a%e8%82%bd%e8%8d%af%e7%89%a9%e8%ae%be%e8%ae%a1%e4%b8%8eai%e7%9a%84%e5%88%9b%e6%96%b0%e8%9e%8d%e5%90%88%ef%bc%9a%e7%bb%b4%e4%ba%9a%e7%94%9f%e7%89%a9%e7%9a%84%e5%89%8d%e6%b2%bf%e6%8e%a2%e7%b4%a2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/moneycompass.com.my\/cn\/"},{"@type":"ListItem","position":2,"name":"\u591a\u80bd\u836f\u7269\u8bbe\u8ba1\u4e0eAI\u7684\u521b\u65b0\u878d\u5408\uff1a\u7ef4\u4e9a\u751f\u7269\u7684\u524d\u6cbf\u63a2\u7d22"}]},{"@type":"WebSite","@id":"https:\/\/moneycompass.com.my\/cn\/#website","url":"https:\/\/moneycompass.com.my\/cn\/","name":"Money Compass CN","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/13995"}],"collection":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/comments?post=13995"}],"version-history":[{"count":0,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/13995\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media\/13996"}],"wp:attachment":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media?parent=13995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/categories?post=13995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/tags?post=13995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}