{"id":14262,"date":"2025-07-30T00:01:00","date_gmt":"2025-07-30T00:01:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%b0%86%e5%9c%a82025%e5%b9%b4esmo%e5%a4%a7%e4%bc%9a%e5%85%ac%e5%b8%83hbm4003%e8%81%94%e5%90%88%e6%9b%bf%e9%9b%b7%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%e6%b2%bb\/"},"modified":"2025-07-30T00:01:00","modified_gmt":"2025-07-30T00:01:00","slug":"%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%b0%86%e5%9c%a82025%e5%b9%b4esmo%e5%a4%a7%e4%bc%9a%e5%85%ac%e5%b8%83hbm4003%e8%81%94%e5%90%88%e6%9b%bf%e9%9b%b7%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%b0%86%e5%9c%a82025%e5%b9%b4esmo%e5%a4%a7%e4%bc%9a%e5%85%ac%e5%b8%83hbm4003%e8%81%94%e5%90%88%e6%9b%bf%e9%9b%b7%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%e6%b2%bb\/","title":{"rendered":"\u548c\u94c2\u533b\u836f\u5c06\u57282025\u5e74ESMO\u5927\u4f1a\u516c\u5e03HBM4003\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684II\u671f\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u4e2d\u56fd\u4e0a\u6d77\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e39<\/span><span class=\"legendSpanClass\">2025\u5e747\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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href=\"https:\/\/mma.prnewswire.com\/media\/1096360\/HB_for_email_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5e94\u7b54\u6709\u9650\uff0c\u76ee\u524d\u4ecd\u662f\u4e00\u9879\u6cbb\u7597\u96be\u9898\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cCTLA-4\u963b\u65ad\u5242\u4e0ePD-(L)1\u6291\u5236\u5242\u5177\u6709\u534f\u540c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u672c\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u7814\u7a76\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05167071\" target=\"_blank\" rel=\"noopener\">NCT05167071<\/a>\uff09\u7eb3\u5165\u7ecf\u591a\u7ebf\u6cbb\u7597\u7684\u975e\u809d\u8f6c\u79fb\u6027MSS 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rel=\"noopener\">ESMO\u7f51\u7ad9<\/a>\u3002<\/p>\n<p>\u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09<\/p>\n<p>\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u5f00\u53d1\u81eaHCAb Harbour 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\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5e94\u7b54\u6709\u9650\uff0c\u76ee\u524d\u4ecd\u662f\u4e00\u9879\u6cbb\u7597\u96be\u9898\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cCTLA-4\u963b\u65ad\u5242\u4e0ePD-(L)1\u6291\u5236\u5242\u5177\u6709\u534f\u540c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u672c\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u7814\u7a76\uff08NCT05167071\uff09\u7eb3\u5165\u7ecf\u591a\u7ebf\u6cbb\u7597\u7684\u975e\u809d\u8f6c\u79fb\u6027MSS mCRC\u60a3\u8005\uff0c\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u5c06\u57282025\u5e74ESMO\u5927\u4f1a\u7684\u58c1\u62a5\u73af\u8282\u8fdb\u884c\u5c55\u793a\u3002 \u76f8\u5173\u58c1\u62a5\u7684\u5177\u4f53\u4fe1\u606f\u5982\u4e0b\uff1a \u6807\u9898\uff1aEfficacy and Safety of HBM4003, an anti-CTLA-4 Antibody, Combined with Tislelizumab in MSS Metastatic Colorectal Cancer: A Multicenter, Phase II Study \u6297CTLA-4\u6297\u4f53HBM4003\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff1a\u4e00\u9879\u591a\u4e2d\u5fc3II\u671f\u7814\u7a76 \u7f16\u53f7\uff1a807P \u62a5\u544a\u4eba\uff1a\u90d1\u98de \u5165\u9009\u6458\u8981\u7684\u5168\u6587\u5c06\u5728\u7ebf\u53d1\u8868\u4e8eESMO\u7f51\u7ad9\u3002 \u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09 \u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u5f00\u53d1\u81eaHCAb Harbour Mice\u00ae\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297\u4f53\u3002\u76f8\u8f83\u4e8e\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u5177\u6709\u663e\u8457\u589e\u52a0\u7684Treg\u7ec6\u80de\u6e05\u9664\u548c\u4f18\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u72ec\u7279\u53ca\u826f\u597d\u7684\u7279\u6027\uff0c\u6709\u52a9\u4e8e\u63d0\u9ad8\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u589e\u5f3a\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u63d0\u5347\u4e86\u9009\u62e9\u6027\u6e05\u9664\u7624\u5185Treg\u7ec6\u80de\u7684\u6f5c\u529b\uff0c\u6709\u671b\u514b\u670d\u73b0\u6709CTLA-4\u7597\u6cd5\u7684\u7597\u6548\u548c\u6bd2\u6027\u74f6\u9888\u3002\u516c\u53f8\u5df2\u5f00\u5c55\u666e\u9c81\u82cf\u62dc\u5355\u6297\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u5168\u7403\u5f00\u53d1\u8ba1\u5212\uff0c\u5e76\u91c7\u7528\u4e86\u666e\u9c81\u82cf\u62dc\u5355\u6297\u7684\u9002\u5e94\u6027\u6cbb\u7597\u8bbe\u8ba1\u3002\u5728\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u7684\u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u8054\u5408PD-1\u6291\u5236\u5242\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u764c\u53ca\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u79ef\u6781\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u6570\u636e\u3002 \u5173\u4e8e\u548c\u94c2\u533b\u836f \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u514d\u75ab\u6027\u75be\u75c5\u53ca\u80bf\u7624\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u56fd\u9645\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002 \u548c\u94c2\u533b\u836f\u4e13\u6709\u7684\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour Mice\u00ae\u80fd\u591f\u751f\u6210\u53cc\u91cd\u3001\u53cc\u8f7b\u94fe\uff08H2L2\uff09\u548c\u4ec5\u91cd\u94fe\uff08HCAb\uff09\u5f62\u5f0f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u57fa\u4e8eHCAb\u6297\u4f53\u5e73\u53f0\u5f00\u53d1\u7684\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\uff08HBICE\u00ae\uff09\u80fd\u591f\u5b9e\u73b0\u4f20\u7edf\u836f\u7269\u8054\u5408\u7597\u6cd5\u65e0\u6cd5\u8fbe\u5230\u7684\u6297\u80bf\u7624\u7597\u6548\u3002\u540c\u65f6\uff0c\u57fa\u4e8eHCAb\u5e73\u53f0\u5f00\u53d1\u7684\u53cc\u7279\u5f02\u6027\u514d\u75ab\u7ec6\u80de\u62ee\u6297\u5242\uff08HBICATM\uff09\u4e3a\u514d\u75ab\u53ca\u708e\u75c7\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u751f\u7269\u836f\u7684\u7814\u53d1\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6301\u3002Harbour Mice\u00ae\u3001HBICE\u00ae\u3001HBICATM\u4e0e\u5355B\u7ec6\u80de\u514b\u9686\u7b5b\u9009\u5e73\u53f0\u5171\u540c\u7ec4\u6210\u4e86\u548c\u94c2\u7684\u4e0b\u4e00\u4ee3\u521b\u65b0\u6cbb\u7597\u6027\u6297\u4f53\u7814\u53d1\u5f15\u64ce\u3002\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u8bbf\u95ee\uff1awww.harbourbiomed.com\u3002 SOURCE \u548c\u94c2\u533b\u836f<\/p>\n","protected":false},"author":0,"featured_media":14263,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-14262","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u548c\u94c2\u533b\u836f\u5c06\u57282025\u5e74ESMO\u5927\u4f1a\u516c\u5e03HBM4003\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684II\u671f\u4e34\u5e8a\u6570\u636e - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u94c2\u533b\u836f\u5c06\u57282025\u5e74esmo\u5927\u4f1a\u516c\u5e03hbm4003\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u548c\u94c2\u533b\u836f\u5c06\u57282025\u5e74ESMO\u5927\u4f1a\u516c\u5e03HBM4003\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684II\u671f\u4e34\u5e8a\u6570\u636e - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u4e2d\u56fd\u4e0a\u6d77\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e392025\u5e747\u670830\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u514d\u75ab\u6027\u75be\u75c5\u53ca\u80bf\u7624\u9886\u57df\u521b\u65b0\u6297\u4f53\u7597\u6cd5\u53d1\u73b0\u53ca\u5f00\u53d1\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5c06\u4e8e10\u670817\u65e5\u81f321\u65e5\u5728\u5fb7\u56fd\u67cf\u6797\u4e3e\u529e\u76842025\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e0a\uff0c\u516c\u5e03\u5176\u65b0\u4e00\u4ee3\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684II\u671f\u4e34\u5e8a\u6570\u636e\u3002 \u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5e94\u7b54\u6709\u9650\uff0c\u76ee\u524d\u4ecd\u662f\u4e00\u9879\u6cbb\u7597\u96be\u9898\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cCTLA-4\u963b\u65ad\u5242\u4e0ePD-(L)1\u6291\u5236\u5242\u5177\u6709\u534f\u540c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u672c\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u7814\u7a76\uff08NCT05167071\uff09\u7eb3\u5165\u7ecf\u591a\u7ebf\u6cbb\u7597\u7684\u975e\u809d\u8f6c\u79fb\u6027MSS mCRC\u60a3\u8005\uff0c\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u5c06\u57282025\u5e74ESMO\u5927\u4f1a\u7684\u58c1\u62a5\u73af\u8282\u8fdb\u884c\u5c55\u793a\u3002 \u76f8\u5173\u58c1\u62a5\u7684\u5177\u4f53\u4fe1\u606f\u5982\u4e0b\uff1a \u6807\u9898\uff1aEfficacy and Safety of HBM4003, an anti-CTLA-4 Antibody, Combined with Tislelizumab in MSS Metastatic Colorectal Cancer: A Multicenter, Phase II Study \u6297CTLA-4\u6297\u4f53HBM4003\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff1a\u4e00\u9879\u591a\u4e2d\u5fc3II\u671f\u7814\u7a76 \u7f16\u53f7\uff1a807P \u62a5\u544a\u4eba\uff1a\u90d1\u98de \u5165\u9009\u6458\u8981\u7684\u5168\u6587\u5c06\u5728\u7ebf\u53d1\u8868\u4e8eESMO\u7f51\u7ad9\u3002 \u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09 \u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u5f00\u53d1\u81eaHCAb Harbour 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