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EXPERT OPINION ON DRUG METABOLISM &amp; TOXICOLOGY. 2020, VOL. 16, NO. 11, 1063\u20131078.<br \/>[2]. Rosenberg R, et al. JAMA Netw Open. 2019 <span class=\"xn-chron\">Dec 2<\/span>;2(12):e1918254.<br \/>[3]. BMC Neuroscience 2014, 15:109.<br \/>[4]. Postgrad Med. 2021 Jan;133(1):71-81<br \/>[5].Moline M, et al. Postgrad Med. 2021 Jan;133(1)71-81<br \/>[6].Chepke C, et al. Prim Care Companion CNS Disord. 2025 Jan 16;27(1)<br \/>[7]. J. Yardley, M. K\u00e4rpp\u00e4, Y. Inoue et al. Sleep Medicine 80 (2021) 333-342<br \/>[8]. Lemborexant\u7f8e\u56fd\u8bf4\u660e\u4e66<br \/>[9].\u300a\u4e2d\u56fd\u6210\u4eba\u5931\u7720\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u5357\u300b\u4e2d\u534e\u795e\u7ecf\u79d1\u6742\u5fd7,2024,57(6):560-584.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<\/div>\n<p>SOURCE  \u536b\u6750\u4e2d\u56fd<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772025\u5e748\u67087\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u536b\u6750\uff08\u4e2d\u56fd\uff09\u836f\u4e1a\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0&#8221;\u536b\u6750\u4e2d\u56fd\u836f\u4e1a&#8221;\uff09\u5ba3\u5e03\uff0c\u9996\u6279\u521b\u65b0\u836f\u7269\u8fbe\u536b\u53ef\u00ae\uff08\u901a\u7528\u540d\uff1a\u83b1\u535a\u96f7\u751f\uff09\u76ee\u524d\u5df2\u62b5\u8fbe\u4e2d\u56fd\u5e76\u987a\u5229\u5b8c\u6210\u836f\u54c1\u68c0\u9a8c\u6d41\u7a0b\uff0c\u5e76\u5df2\u6b63\u5f0f\u542f\u7a0b\u53d1\u5f80\u5168\u56fd\u5404\u5927\u533b\u9662\u53ca\u6307\u5b9a\u836f\u5e97\uff0c\u5373\u5c06\u4e3a\u5931\u7720\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u6cbb\u7597\u9009\u62e9\u3002 \u83b1\u535a\u96f7\u751f\u9664\u4e86\u5728\u56fd\u5185\u533b\u7597\u673a\u6784\u548c\u836f\u623f\u8fdb\u884c\u836f\u54c1\u914d\u9001\u548c\u5904\u65b9\u5916\uff0c\u540c\u6837\u53ef\u4ee5\u5728\u4eac\u4e1c\u5065\u5eb7\u7ebf\u4e0a\u5e73\u53f0\u8fdb\u884c\u5904\u65b9\uff0c\u89e3\u51b3\u5931\u7720\u4eba\u7fa4\u7684\u7528\u836f\u9700\u6c42\u3002 \u83b1\u535a\u96f7\u751f\u901a\u8fc7\u7ade\u4e89\u6027\u7ed3\u5408\u4e24\u79cd\u98df\u6b32\u7d20\u53d7\u4f53\u4e9a\u578b\uff08OX1R\u548cOX2R\uff09\u7cbe\u51c6\u8c03\u8282\u98df\u6b32\u7d20\u7cfb\u7edf\uff0c\u901a\u8fc7\u6291\u5236\u98df\u6b32\u7d20\u7684\u4fc3\u89c9\u9192\u4f5c\u7528\uff0c\u8bf1\u5bfc\u7761\u7720[1]\u3002\u83b1\u535a\u96f7\u751f\u53ef\u7f29\u77ed\u5165\u7761\u65f6\u95f4\u3001\u51cf\u5c11\u591c\u95f4\u89c9\u9192\u65f6\u95f4\u3001\u5ef6\u957f\u603b\u7761\u7720\u65f6\u95f4\uff0c\u5e76\u4e14\uff0c\u4e0d\u540c\u4e8e\u4f20\u7edf\u7684GABA-A\u4fc3\u7720\u836f\u6291\u5236REM\u671f\uff0c\u5176\u53ef\u540c\u65f6\u5ef6\u957f\u975e\u5feb\u901f\u773c\u52a8\u671f\uff08NREM\uff09\u548c\u5feb\u901f\u773c\u52a8\u7761\u7720\uff08REM\uff09\uff0c\u6709\u52a9\u4e8e\u6b63\u5411\u8c03\u8282\u7761\u7720\u7ed3\u6784\uff0c\u4f7f\u5176\u66f4\u63a5\u8fd1\u751f\u7406\u6027\u7761\u7720[2,3]\u5373\u81ea\u7136\u7761\u7720\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff0c\u670d\u7528\u83b1\u535a\u96f7\u751f\u540e\uff0c\u60a3\u8005\u65e5\u95f4\u6d3b\u52a8\u4e0d\u53d7\u5f71\u54cd [4,5,6]\u3002\u4e0d\u4f1a\u5bfc\u81f4\u8eab\u4f53\u4f9d\u8d56\uff0c\u4e0d\u4f1a\u51fa\u73b0\u6212\u65ad\u75c7\u72b6\uff0c\u4e5f\u4e0d\u4f1a\u51fa\u73b0\u5931\u7720\u53cd\u5f39\uff0c\u4e0a\u5e02\u540e\u81f3\u4eca\u6ca1\u6709\u53d1\u73b0\u5177\u6709\u6210\u763e\u6027[7,8,9]\u3002 2019\u5e74\u83b1\u535a\u96f7\u751f\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u4e4b\u540e\u9646\u7eed\u5728\u65e5\u672c\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u4e2d\u56fd\u9999\u6e2f\u3001\u4e2d\u56fd\u6fb3\u95e8\u7b4920\u591a\u4e2a\u56fd\u5bb6\u53ca\u5730\u533a\u83b7\u6279\u4e0a\u5e02\u3002\u5728\u7f8e\u56fd\uff0c\u83b1\u535a\u96f7\u751f\u83b7\u6279\u7684\u9002\u5e94\u75c7\u4e3a\u6cbb\u7597\u5165\u7761\u6216\u7761\u7720\u7ef4\u6301\u56f0\u96be\u7684\u6210\u4eba\u5931\u7720\u60a3\u8005\u3002\u5728\u65e5\u672c\uff0c\u5176\u9002\u5e94\u75c7\u4e3a\u6cbb\u7597\u5931\u7720\uff0c\u5e76\u88ab\u7eb3\u5165\u300a\u65e5\u672c\u5931\u7720\u969c\u788d\u6cbb\u7597\u4e13\u5bb6\u5171\u8bc6\u300b\uff0c\u6210\u4e3a\u7761\u7720\u8d77\u59cb\u56f0\u96be\u548c\u7761\u7720\u7ef4\u6301\u56f0\u96be\u6cbb\u7597\u7684\u4e3b\u8981\u63a8\u8350\u836f\u7269\uff0c\u5e7f\u53d7\u533b\u5b66\u754c\u548c\u5931\u7720\u60a3\u8005\u6b22\u8fce\u30022025\u5e745\u6708\uff0c\u83b1\u535a\u96f7\u751f\u6b63\u5f0f\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u5165\u7761\u56f0\u96be\u548c\/\u6216\u7761\u7720\u7ef4\u6301\u56f0\u96be\u578b\u5931\u7720\uff0c\u5e76\u7eb3\u5165\u4e86\u300a\u4e2d\u56fd\u6210\u4eba\u5931\u7720\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u5357\u300b\u3002 \u536b\u6750\u4e2d\u56fd\u836f\u4e1a\u59cb\u7ec8\u5c06\u795e\u7ecf\u79d1\u5b66\u9886\u57df\uff08\u5305\u62ec\u5931\u7720\u75c7\uff09\u5b9a\u4f4d\u4e3a\u5173\u952e\u6cbb\u7597\u9886\u57df\u4e4b\u4e00\u3002\u6b64\u6b21\u9996\u6279\u521b\u65b0\u836f\u7269\u83b1\u535a\u96f7\u751f\u7684\u5168\u56fd\u4f9b\u8d27\uff0c\u4e0d\u4ec5\u5c06\u4e3a\u5931\u7720\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u548c\u7ba1\u7406\u5de5\u5177\uff0c\u52a9\u529b\u91cd\u5851\u81ea\u7136\u7761\u7720\u8282\u5f8b\uff0c\u66f4\u671f\u5f85\u901a\u8fc7\u7cbe\u51c6\u5e72\u9884\u91cd\u65b0\u5b9a\u4e49\u7761\u7720\u5065\u5eb7\u7ba1\u7406\u6807\u51c6\uff0c\u4e3a&#8221;\u5065\u5eb7\u4e2d\u56fd2030&#8243;\u6162\u6027\u75c5\u9632\u63a7\u76ee\u6807\u8d21\u732e\u4e13\u4e1a\u529b\u91cf\u3002 \u53c2\u8003\u6587\u732e [1]. EXPERT OPINION ON DRUG METABOLISM &amp; TOXICOLOGY. 2020, VOL. 16, NO. 11, 1063\u20131078.[2]. Rosenberg R, et al. JAMA Netw Open. 2019 Dec 2;2(12):e1918254.[3]. BMC Neuroscience 2014, 15:109.[4]. Postgrad Med. 2021 Jan;133(1):71-81[5].Moline M, et al. Postgrad Med. 2021 Jan;133(1)71-81[6].Chepke C, et al. 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