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\u548c\u9ec4\u533b\u836f\u975e\u6267\u884c\u4e3b\u5e2d\u827e\u4e50\u5fb7\u535a\u58eb\uff08Dr Dan Eldar<\/span>\uff09\u8868\u793a\uff1a”\u51ed\u501f\u7a33\u5065\u7684\u8d22\u52a1\u72b6\u51b5\u3001\u5f3a\u52b2\u7684\u8425\u8fd0\u53ca\u4ee4\u4eba\u671f\u5f85\u7684\u5168\u65b0ATTC\u5e73\u53f0\uff0c\u548c\u9ec4\u533b\u836f\u5df2\u4e3a\u8e0f\u5165\u65b0\u7684\u589e\u957f\u65f6\u671f\u4f5c\u597d\u51c6\u5907\u3002\u968f\u7740\u4e0e\u4e2d\u56fd\u751f\u7269\u79d1\u6280\u516c\u53f8\u7684\u6388\u6743\u4ea4\u6613\u673a\u4f1a\u7ee7\u7eed\u5f97\u5230\u8de8\u56fd\u5236\u836f\u516c\u53f8\u9752\u7750\uff0c\u5408\u4f5c\u4e5f\u4f9d\u7136\u662f\u6211\u4eec\u7684\u6218\u7565\u91cd\u70b9\u4e4b\u4e00\u3002\u8fd1\u51e0\u4e2a\u6708\u6765\uff0c\u5e02\u573a\u60c5\u7eea\u548c\u8868\u73b0\u663e\u8457\u6539\u5584\u3002\u4e2d\u56fd\u672c\u571f\u7684\u836f\u54c1\u653f\u7b56\u548c\u5b9a\u4ef7\u73af\u5883\u4e5f\u53cd\u6620\u51fa\u5bf9\u521b\u65b0\u836f\u5f00\u53d1\u7684\u91cd\u70b9\u652f\u6301\uff0c\u5546\u4fdd\u521b\u65b0\u836f\u76ee\u5f55\u6709\u671b\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u51fa\u53f0\uff0c\u4e3a\u672a\u6765\u5efa\u7acb\u591a\u5143\u5316\u3001\u591a\u5c42\u6b21\u7684\u533b\u7597\u793e\u4f1a\u4fdd\u969c\u652f\u4ed8\u4f53\u7cfb\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n

\u6211\u4eec\u8ba1\u5212\u5ba1\u614e\u5e76\u79ef\u6781\u5730\u90e8\u7f72\u8d44\u6e90\uff0c\u52a0\u5feb\u63a8\u8fdb\u4e00\u7cfb\u5217\u6765\u81ea\u521b\u65b0ATTC\u5e73\u53f0\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u8fdb\u7a0b\uff0c\u5305\u62ec\u5728\u4e2d\u56fd\u53ca\u6d77\u5916\u540c\u6b65\u5f00\u5c55\u4e34\u5e8a\u5f00\u53d1\u3002\u6211\u4eec\u4e8c\u5341\u5e74\u6765\u5728\u81ea\u4e3b\u53d1\u73b0\u3001\u5f00\u5c55\u5927\u89c4\u6a21\u7684\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e0e\u56fd\u9645\u5408\u4f5c\u4f19\u4f34\u5408\u4f5c\u4ee5\u53ca\u6210\u529f\u53d6\u5f97\u5168\u7403\u76d1\u7ba1\u6279\u51c6\u65b9\u9762\u6240\u79ef\u7d2f\u7684\u7ecf\u9a8c\uff0c\u5c06\u8d4b\u80fd\u6211\u4eec\u5e26\u6765\u66f4\u591a\u521b\u65b0\u836f\u7269\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5927\u91cf\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002”<\/p>\n

\u548c\u9ec4\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u82cf\u6170\u56fd\u535a\u58eb\u8868\u793a\uff1a”\u57282025\u5e74\u4e0a\u534a\u5e74\uff0c\u6211\u4eec\u8fbe\u6210\u4e86\u591a\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u5176\u4e2d\u4e00\u4e9b\u66f4\u662f\u65e9\u4e8e\u9884\u671f\u30026\u6708\u521dASCO\u5e74\u4f1a\u6700\u65b0\u7a81\u7834\u6027\u53e3\u5934\u62a5\u544a\u4e0a\u516c\u5e03\u7684SACHI\u7814\u7a76\u6570\u636e\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\uff0c\u4f50\u8bc1\u4e86\u6c83\u745e\u6c99\u00ae\u5728\u5e02\u573a\u4e2d\u7684\u4e34\u5e8a\u5b9e\u529b\u53ca\u5546\u4e1a\u4f18\u52bf\u3002\u8fd9\u662f\u9488\u5bf9EGFR TKI\u8010\u836f\u80ba\u764c\u60a3\u8005\u7684\u5168\u7403\u9996\u4e2a\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u7b5b\u9009\u7684\u5173\u952e\u6027\u7814\u7a76\uff0c\u5728\u6b64\u7c7b\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u660e\u786e\u7684\u4e34\u5e8a\u83b7\u76ca\u30026\u6708\u5e95\uff0c\u6c83\u745e\u6c99\u00ae\u5728\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u4e2d\u56fd\u4e0a\u5e02\u7533\u8bf7\u63d0\u4ea4\u540e\u7684\u516d\u4e2a\u6708\u540e\u5c31\u8f83\u9884\u671f\u63d0\u524d\u53d6\u5f97\u6279\u51c6\uff0c\u7b26\u5408\u8d44\u683c\u53c2\u4e0e\u672c\u5e74\u5ea6\u7684\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u8c08\u5224\u3002\u540c\u6708\uff0c\u57fa\u4e8eFRUSICA-2 III\u671f\u7814\u7a76\u7684\u79ef\u6781\u6570\u636e\uff0c\u7231\u4f18\u7279\u00ae\u7b2c\u4e09\u9879\u9002\u5e94\u75c7\u7528\u4e8e\u6cbb\u7597\u80be\u764c\u7684\u4e0a\u5e02\u7533\u8bf7\u4ea6\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u53d7\u7406\uff0c\u6570\u636e\u5c06\u4e8eESMO\u5e74\u4f1a\u516c\u5e03\u3002\u7ee73\u6708\u83b7\u6279\u540e\uff0c\u6211\u4eec\u4ea6\u4e8e7\u6708\u63a8\u51fa\u6211\u4eec\u7684\u9996\u6b3e\u8840\u6db2\u80bf\u7624\u836f\u7269\u8fbe\u552f\u73c2\u00ae\uff08TAZVERIK\u00ae\uff0c\u4ed6\u6cfd\u53f8\u4ed6\/tazemetostat\uff09\u5546\u4e1a\u4e0a\u5e02\u3002<\/p>\n

\u6211\u4eec\u76f8\u4fe1\u51ed\u501f\u4e2d\u56fd\u9002\u5e94\u75c7\u6269\u5c55\u53ca\u6d77\u5916\u5e02\u573a\u6e17\u900f\u7387\u63d0\u5347\uff0c2025\u5e74\u4e0b\u534a\u5e74\u9500\u552e\u589e\u957f\u5c06\u91cd\u62fe\u901f\u5ea6\u3002\u8fd1\u671f\uff0c\u6211\u4eec\u6b63\u63a8\u52a8\u6765\u81ea\u5173\u952e\u6280\u672f\u5e73\u53f0ATTC\u9879\u76ee\u7684\u591a\u4e2a\u5019\u9009\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\uff0c\u8fd9\u5c06\u4e30\u5bcc\u6211\u4eec\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5e76\u521b\u9020\u66f4\u591a\u7684\u5408\u4f5c\u673a\u4f1a\u3002”<\/p>\n

2025\u5e74\u4e2d\u671f\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55<\/p>\n

I. \u5546\u4e1a\u8425\u8fd0<\/p>\n

2025\u5e74\u4e0a\u534a\u5e74\uff0c\u7531\u6b66\u7530\u8d1f\u8d23\u9500\u552e\u7684FRUZAQLA\u00ae\u5e02\u573a\u9500\u552e\u989d\u589e\u957f25%\u81f31.628\u4ebf\u7f8e\u5143\uff0c\u8fd9\u5f97\u76ca\u4e8e\u8fc4\u4eca\u5728\u8d85\u8fc730\u4e2a\u56fd\u5bb6\u83b7\u5f97\u6279\u51c6\u540e\u5b9e\u73b0\u5f3a\u52b2\u589e\u957f\uff0c\u5305\u62ec\u4e8e2025\u5e74\u65b0\u589e\u768410\u591a\u4e2a\u5e02\u573a\u3002\u53bb\u5e74\u5df2\u4e8e\u7f8e\u56fd\u3001\u897f\u73ed\u7259\u548c\u65e5\u672c\u7eb3\u5165\u533b\u4fdd\u8303\u56f4\uff0c\u53ca\u4e8e2025\u5e747\u6708\u5728\u82f1\u683c\u5170\u548c\u5a01\u5c14\u58eb\u53d6\u5f97\u7eb3\u5165\u82f1\u56fd\u56fd\u5bb6\u533b\u7597\u670d\u52a1\uff08NHS\uff09\u4fdd\u969c\u8303\u56f4\u7684\u79ef\u6781\u5efa\u8bae\u3002<\/p>\n

\u4e2d\u56fd\u533b\u836f\u884c\u4e1a\u6b63\u5728\u7ecf\u5386\u591a\u65b9\u9762\u7684\u53d8\u9769\u3002\u4e3a\u786e\u4fdd\u548c\u9ec4\u533b\u836f\u5b9e\u73b0\u53ef\u6301\u7eed\u7684\u957f\u671f\u53d1\u5c55\uff0c\u548c\u9ec4\u533b\u836f\u4f18\u5316\u4e86\u9500\u552e\u56e2\u961f\u7ed3\u6784\uff0c\u5efa\u7acb\u66f4\u9ad8\u6548\u7684\u5546\u4e1a\u5316\u7ec4\u7ec7\u5e76\u63d0\u5347\u751f\u4ea7\u529b\u3002\u968f\u7740\u5176\u4ea7\u54c1\u65e5\u8d8b\u6210\u719f\uff0c\u5e02\u573a\u7ade\u4e89\u4e5f\u6108\u53d1\u6fc0\u70c8\uff0c\u548c\u9ec4\u533b\u836f\u5f3a\u5316\u4e86\u7b56\u7565\uff0c\u7ee7\u7eed\u4e13\u6ce8\u4e8e\u4ee5\u79d1\u5b66\u4e3a\u9a71\u52a8\u7684\u5546\u4e1a\u6d3b\u52a8\uff0c\u4ee5\u8fdb\u4e00\u6b65\u7a81\u51fa\u5176\u4ea7\u54c1\u7684\u5dee\u5f02\u5316\u7ade\u4e89\u529b\u30022025\u5e74\u4e0a\u534a\u5e74\uff0c\u7231\u4f18\u7279\u00ae\u3001\u82cf\u6cf0\u8fbe\u00ae\u548c\u6c83\u745e\u6c99\u00ae\u5728\u4e2d\u56fd\u5e02\u573a\u7684\u9500\u552e\u989d\u8f832024\u5e74\u4e0a\u534a\u5e74\u6709\u6240\u4e0b\u964d\uff0c\u53cd\u6620\u4e86\u5e02\u573a\u7ade\u4e89\u4ee5\u53ca\u9500\u552e\u56e2\u961f\u548c\u8425\u9500\u6218\u7565\u8c03\u6574\u6240\u5e26\u6765\u7684\u8fc7\u6e21\u6027\u5f71\u54cd\u3002<\/p>\n

\u603b\u5e02\u573a\u9500\u552e\u989d\u4e0b\u964d4%\u3002\u7efc\u5408\u6536\u5165\u4e0b\u964d22%\uff0c\u4e3b\u8981\u7531\u4e8e\u4e2d\u56fd\u5e02\u573a\u9500\u552e\u989d\u4e0b\u964d\uff0c\u4f46FRUZAQLA\u00ae\u6536\u5165\u5e73\u7a33\uff0c\u62b5\u6d88\u4e86\u8fd9\u4e00\u5f71\u54cd\u3002<\/p>\n

\u5176\u4ed6\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u6536\u5165\uff08\u5305\u62ec\u9996\u4ed8\u6b3e\u6216\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3001\u7814\u53d1\u670d\u52a1\u6536\u5165\u53ca\u5411\u5408\u4f5c\u4f19\u4f34\u6388\u51fa\u8bb8\u53ef\u6536\u5165\uff09\u589e\u957f9%\u81f34,440\u4e07\u7f8e\u5143\u3002\u5176\u4ed6\u4e1a\u52a1\u6536\u5165\uff08\u5305\u62ec\u5904\u65b9\u836f\u5206\u9500\uff09\u4fdd\u6301\u5e73\u7a33\uff0c\u5bfc\u81f4\u7efc\u5408\u6536\u5165\u603b\u989d\u4e3a2.777\u4ebf\u7f8e\u5143\uff0c\u4e0b\u964d9%\u3002<\/p>\n

\n

\uff08\u672a\u7ecf\u5ba1\u6838\uff0c\u767e\u4e07\u7f8e\u5143\uff09<\/span><\/span><\/p>\n

\u5e02\u573a\u9500\u552e\u989d<\/span>*<\/span><\/span><\/p>\n

\u7efc\u5408\u6536\u5165<\/span>**<\/span><\/span><\/p>\n

<\/p>\n

2025<\/span>\u5e74<\/span>\u00a0\u4e0a\u534a\u5e74<\/span><\/span><\/p>\n

2024<\/span>\u5e74\u4e0a\u534a\u5e74<\/span><\/span><\/p>\n

%\u0394<\/span><\/span><\/p>\n

(<\/span>\u56fa\u5b9a\u6c47\u7387<\/span>)<\/span><\/span><\/p>\n

2025<\/span>\u5e74\u4e0a\u534a\u5e74<\/span><\/span><\/p>\n

2024<\/span>\u5e74\u4e0a\u534a\u5e74<\/span><\/span><\/p>\n

%\u0394<\/span><\/span><\/p>\n

(<\/span>\u56fa\u5b9a\u6c47\u7387<\/span>)<\/span><\/span><\/p>\n

FRUZAQLA\u00ae<\/span><\/p>\n

$162.8<\/span><\/p>\n

$130.5<\/span><\/p>\n

+25\u00a0%<\/span><\/p>\n

(+25\u00a0%)<\/span><\/p>\n

$43.1<\/span><\/p>\n

$42.8<\/span><\/p>\n

+1\u00a0%<\/span><\/p>\n

(+1\u00a0%)<\/span><\/p>\n

\u7231\u4f18\u7279\u00ae<\/span><\/p>\n

$43.0<\/span><\/p>\n

$61.0<\/span><\/p>\n

-29\u00a0%<\/span><\/p>\n

(-29\u00a0%)<\/span><\/p>\n

$33.6<\/span><\/p>\n

$46.0<\/span><\/p>\n

-27\u00a0%<\/span><\/p>\n

(-27\u00a0%)<\/span><\/p>\n

\u82cf\u6cf0\u8fbe\u00ae<\/span><\/p>\n

$12.7<\/span><\/p>\n

$25.4<\/span><\/p>\n

-50\u00a0%<\/span><\/p>\n

(-50\u00a0%)<\/span><\/p>\n

$12.7<\/span><\/p>\n

$25.4<\/span><\/p>\n

-50\u00a0%<\/span><\/p>\n

(-50\u00a0%)<\/span><\/p>\n

\u6c83\u745e\u6c99\u00ae<\/span><\/p>\n

$15.2<\/span><\/p>\n

$25.9<\/span><\/p>\n

-41\u00a0%<\/span><\/p>\n

(-41\u00a0%)<\/span><\/p>\n

$9.0<\/span><\/p>\n

$13.1<\/span><\/p>\n

-32\u00a0%<\/span><\/p>\n

(-32\u00a0%)<\/span><\/p>\n

\u8fbe\u552f\u73c2\u00ae<\/span><\/p>\n

$0.7<\/span><\/p>\n

$0.5<\/span><\/p>\n

+49\u00a0%<\/span><\/p>\n

(+49\u00a0%)<\/span><\/p>\n

$0.7<\/span><\/p>\n

$0.5<\/span><\/p>\n

+49\u00a0%<\/span><\/p>\n

(+49\u00a0%)<\/span><\/p>\n

\u80bf\u7624\u4ea7\u54c1<\/span><\/span><\/p>\n

$234.4<\/span><\/p>\n

$243.3<\/span><\/p>\n

-4\u00a0%<\/span><\/p>\n

(-4\u00a0%)<\/span><\/p>\n

$99.1<\/span><\/p>\n

$127.8<\/span><\/p>\n

-22\u00a0%<\/span><\/p>\n

(-22\u00a0%)<\/span><\/p>\n

\u6b66\u7530\u9996\u4ed8\u6b3e\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u53ca\u7814\u53d1\u670d\u52a1\u6536\u5165<\/span><\/p>\n

$29.5<\/span><\/p>\n

$33.8<\/span><\/p>\n

-13\u00a0%<\/span><\/p>\n

(-13\u00a0%)<\/span><\/p>\n

\u5176\u4ed6\u6536\u5165 (\u7814\u53d1\u670d\u52a1\u53ca\u8bb8\u53ef)<\/span><\/p>\n

$14.9<\/span><\/p>\n

$7.1<\/span><\/p>\n

+111\u00a0%<\/span><\/p>\n

(+111\u00a0%)<\/span><\/p>\n

\u80bf\u7624<\/span>\/<\/span>\u514d\u75ab\u4e1a\u52a1\u5408\u8ba1<\/span><\/span><\/p>\n

$143.5<\/span><\/p>\n

$168.7<\/span><\/p>\n

-15\u00a0%<\/span><\/p>\n

(-15\u00a0%)<\/span><\/p>\n

\u5176\u4ed6\u4e1a\u52a1<\/span><\/p>\n

$134.2<\/span><\/p>\n

$137.0<\/span><\/p>\n

-2\u00a0%<\/span><\/p>\n

(-1\u00a0%)<\/span><\/p>\n

\u6536\u5165\u603b\u989d<\/span><\/span><\/p>\n

$277.7<\/span><\/p>\n

$305.7<\/span><\/p>\n

-9\u00a0%<\/span><\/p>\n

(-9\u00a0%)<\/span><\/p>\n<\/div>\n

*\u00a0\u00a0\u5c31FRUZAQLA\u00ae\u3001\u7231\u4f18\u7279\u00ae\u548c\u6c83\u745e\u6c99\u00ae\uff0c\u4e3b\u8981\u5206\u522b\u4ee3\u8868\u6b66\u7530\u3001\u793c\u6765\u548c\u963f\u65af\u5229\u5eb7\u63d0\u4f9b\u7684\u5bf9\u7b2c\u4e09\u65b9\u7684\u603b\u9500\u552e\u989d\u3002
**\u00a0\u5c31FRUZAQLA\u00ae\uff0c\u4ee3\u8868\u6b66\u7530\u652f\u4ed8\u7684\u751f\u4ea7\u6536\u5165\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\uff1b\u5c31\u7231\u4f18\u7279\u00ae\uff0c\u4ee3\u8868\u793c\u6765\u5411\u548c\u9ec4\u533b\u836f\u652f\u4ed8\u7684\u751f\u4ea7\u6536\u5165\u3001\u63a8\u5e7f\u53ca\u8425\u9500\u670d\u52a1\u6536\u5165\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u4ee5\u53ca\u7531\u548c\u9ec4\u533b\u836f\u5f00\u5177\u53d1\u7968\u7684\u5bf9\u5176\u4ed6\u7b2c\u4e09\u65b9\u7684\u9500\u552e\u989d\uff1b\u5c31\u6c83\u745e\u6c99\u00ae\uff0c\u4ee3\u8868\u963f\u65af\u5229\u5eb7\u5411\u548c\u9ec4\u533b\u836f\u652f\u4ed8\u7684\u751f\u4ea7\u6536\u5165\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u4ee5\u53ca\u7531\u548c\u9ec4\u533b\u836f\u5f00\u5177\u53d1\u7968\u7684\u5bf9\u5176\u4ed6\u7b2c\u4e09\u65b9\u7684\u9500\u552e\u989d\uff1b\u5c31\u82cf\u6cf0\u8fbe\u00ae\u53ca\u8fbe\u552f\u73c2\u00ae\uff0c\u4ee3\u8868\u548c\u9ec4\u533b\u836f\u5bf9\u7b2c\u4e09\u65b9\u7684\u4ea7\u54c1\u9500\u552e\u989d\u3002<\/p>\n

II.\u00a0\u6ce8\u518c\u5ba1\u6279\u8fdb\u5c55<\/p>\n

2025\u5e746\u6708\uff0c\u8d5b\u6c83\u66ff\u5c3c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\uff0c\u8054\u5408\u6cf0\u745e\u6c99\u00ae\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u4f34\u6709MET\u6269\u589e\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u89e6\u53d1\u6765\u81ea\u963f\u65af\u5229\u5eb7\u76841,100\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u30022025\u5e741\u6708\uff0c\u8d5b\u6c83\u66ff\u5c3c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\uff0c\u7528\u4e8e\u4e00\u7ebf\u53ca\u4e8c\u7ebf\uff08\u9644\u6761\u4ef6\u6279\u51c6\u8f6c\u4e3a\u5e38\u89c4\u6279\u51c6\uff09\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u30022025\u5e742\u6708\uff0c\u8d5b\u6c83\u66ff\u5c3c\u901a\u8fc7”1+”\u673a\u5236\u5728\u4e2d\u56fd\u9999\u6e2f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u30022025\u5e743\u6708\uff0c\u4ed6\u6cfd\u53f8\u4ed6\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u9644\u6761\u4ef6\u6279\u51c6\uff0c\u7528\u4e8e\u4e09\u7ebf\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027EZH2\u7a81\u53d8\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3002<\/p>\n

III. \u540e\u671f\u4e34\u5e8a\u9879\u76ee\u8fdb\u5c55<\/p>\n

\u8d5b\u6c83\u66ff\u5c3c\uff08\u4e2d\u56fd\u5546\u54c1\u540d\uff1a\u6c83\u745e\u6c99\u00ae\uff09\uff0c\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u53e3\u670d\u7684MET\u6291\u5236\u5242\u00a0<\/p>\n

\u8054\u5408\u6cf0\u745e\u6c99\u00ae\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u4f34\u6709MET\u6269\u589e\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684SACHI\u4e2d\u56fdIII\u671f\u7814\u7a76\u7ed3\u679c\u4e8e2025\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\uff0c\u7ed3\u679c\u663e\u793a\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u4e2d\u4f4dPFS\u4e3a8.2\u4e2a\u6708\uff0c\u800c\u5316\u7597\u7ec4\u5219\u4e3a4.5\u4e2a\u6708\uff08HR 0.34\uff0cp<0.0001\uff09\uff1b\u5728\u65e2\u5f80\u66fe\u63a5\u53d7\u4e09\u4ee3EGFR TKI\u6cbb\u7597\u7684\u4e9a\u7ec4\u4e2d\uff0c\u4e2d\u4f4dPFS\u4e3a6.9\u4e2a\u6708\uff0c\u800c\u5316\u7597\u7ec4\u5219\u4e3a3.0\u4e2a\u6708\uff08HR 0.32\uff0cp<0.0001\uff09\uff08NCT05015608\uff09\u3002\u8054\u5408\u6cf0\u745e\u6c99\u00ae\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u4f34\u6709MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684SAVANNAH\u5168\u7403II\u671f\u7814\u7a76\u7ed3\u679c\u4e8e2025\u5e74ELCC\u5e74\u4f1a\u4e0a\u516c\u5e03\uff0c\u7ed3\u679c\u663e\u793aORR\u4e3a56%\uff0c\u4e2d\u4f4dPFS\u4e3a7.4\u4e2a\u6708\u53ca\u4e2d\u4f4dDoR\u4e3a7.1\u4e2a\u6708\uff08NCT03778229\uff09\u3002\u591a\u9879\u7814\u7a76\u7ee7\u7eed\u5165\u7ec4\u4e2d\uff0c\u5305\u62ec\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u4f34\u6709MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684SAFFRON\u5168\u7403III\u671f\u7814\u7a76\uff08NCT05261399\uff09\uff0c\u8be5\u7814\u7a76\u6709\u671b\u652f\u6301\u4e8e\u5168\u7403\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff1b\u4ee5\u53ca\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u4f34\u6709MET\u8fc7\u8868\u8fbe\u7684EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684SANOVO\u4e2d\u56fdIII\u671f\u7814\u7a76\uff08NCT05009836\uff09\u3002\u7528\u4e8e\u4e09\u7ebf\u6cbb\u7597\u4f34\u6709MET\u6269\u589e\u80c3\u764c\u60a3\u8005\u7684\u4e2d\u56fdII\u671f\u6ce8\u518c\u7814\u7a76\u5b8c\u6210\u60a3\u8005\u62db\u52df\uff08NCT04923932\uff09\u3002<\/p>\n

\u8d5b\u6c83\u66ff\u5c3c\u6f5c\u5728\u7684\u4e34\u5e8a\u5173\u952e\u8fdb\u5c55\uff1a<\/p>\n

\u4e8e2025\u5e74\u4e0b\u534a\u5e74\u5b8c\u6210SAFFRON III\u671f\u7814\u7a76\u7684\u60a3\u8005\u62db\u52df\uff0c\u5e76\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u8bfb\u51fa\u6570\u636e\u3002\u4e8e2025\u5e74\u4e0b\u534a\u5e74\u5b8c\u6210SANOVO\u4e2d\u56fdIII\u671f\u7814\u7a76\u7684\u60a3\u8005\u62db\u52df\u3002<\/p>\n

\u544b\u55b9\u66ff\u5c3c\uff08\u4e2d\u56fd\u5546\u54c1\u540d\uff1a\u7231\u4f18\u7279\u00ae\uff0c\u6d77\u5916\u5546\u54c1\u540d\uff1aFRUZAQLA\u00ae\uff09\uff0c\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u7684VEGFR\u53e3\u670d\u6291\u5236\u5242<\/p>\n

2025\u5e743\u6708\uff0c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdIII\u671f\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff08NCT05522231\uff09\u3002\u8054\u5408\u62d3\u76ca\u00ae\uff08TUOYI\u00ae\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\/toripalimab\uff09\u6216\u8fbe\u4f2f\u8212\u00ae\u7528\u4e8e\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\/\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7ed3\u76f4\u80a0\u764c\u7684\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e2d\u56fdII\u671f\u7814\u7a76\u7ed3\u679c\u4e8eAACR\u5e74\u4f1a\u4e0a\u516c\u5e03\uff0c\u7ed3\u679c\u663e\u793a\u4e2d\u4f4dPFS\u4e3a13.2\u4e2a\u6708\u53ca\u4e2d\u4f4dOS\u4e3a29.0\u4e2a\u6708\uff08NCT04483219\uff09\u3002<\/p>\n

\u7d22\u4e50\u5339\u5c3c\u5e03\uff08HMPL-523\uff0csovleplenib\uff09\uff0c\u4e00\u79cd\u7814\u7a76\u6027\u7684\u9ad8\u9009\u62e9\u6027\u53e3\u670dSyk\u6291\u5236\u5242<\/p>\n

\u6b63\u5728\u8fdb\u884c\u4e2d\u7684ESLIM-01\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u56fd\u5bb6\u836f\u76d1\u5c40\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5ba1\u8bc4\uff0c\u8981\u6c42\u66f4\u4f4e\u7684\u6742\u8d28\u6c34\u5e73\uff0c\u56e0\u6b64\u9700\u8981\u8fdb\u4e00\u6b65\u751f\u4ea7\u9a8c\u8bc1\u53ca\u7a33\u5b9a\u6027\u6d4b\u8bd5\u3002\u76ee\u6807\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u91cd\u65b0\u63d0\u4ea4\uff0c\u5e76\u4e8e2026\u5e74\u4e0b\u534a\u5e74\u6eda\u52a8\u63d0\u4ea4\u8865\u5145\u6570\u636e\u3002\u672a\u6765\uff0c\u516c\u53f8\u6709\u610f\u7ee7\u7eed\u6d77\u5916\u5f00\u53d1\u3002\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u75c7\u7684\u4e2d\u56fdII\u671f\u7814\u7a76\u7ed3\u679c\u4e8eEHA\u5e74\u4f1a\u4e0a\u516c\u5e03\u53ca\u4e8e2025\u5e74\u5728\u300a\u67f3\u53f6\u5200\u2022\u8840\u6db2\u75c5\u5b66\uff08The Lancet Haematology\uff09\u300b\u4e0a\u53d1\u8868\uff0c\u7ed3\u679c\u663e\u793a\u6574\u4f53\u5e94\u7b54\u7387\u4e3a66.7%\uff0c\u5e76\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff08NCT05535933\uff09\u3002\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u7684ESLIM-02\u4e2d\u56fdIII\u671f\u7814\u7a76\u5df2\u4e8e2025\u5e746\u6708\u5b8c\u6210\u60a3\u8005\u62db\u52df\uff08NCT05535933\uff09\u3002<\/p>\n

\u7d22\u4e50\u5339\u5c3c\u5e03\u6f5c\u5728\u7684\u76d1\u7ba1\u5173\u952e\u8fdb\u5c55\uff1a<\/p>\n

\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u91cd\u65b0\u63d0\u4ea4\u57fa\u4e8eESLIM-01\u7814\u7a76\u7684\u56fd\u5bb6\u836f\u76d1\u5c40\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NCT05029635\uff09\u3002\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u63d0\u4ea4\u57fa\u4e8eESLIM-02\u7814\u7a76\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08NCT05535933\uff09\u3002<\/p>\n

\u7d22\u51e1\u66ff\u5c3c\uff08\u4e2d\u56fd\u5546\u54c1\u540d\uff1a\u82cf\u6cf0\u8fbe\u00ae\uff09\uff0c\u4e00\u79cdVEGFR\u3001FGFR\u53caCSF-1R\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u6291\u5236\u5242<\/p>\n

\u7d22\u51e1\u66ff\u5c3c\u6f5c\u5728\u7684\u4e34\u5e8a\u5173\u952e\u8fdb\u5c55\uff1a<\/p>\n

\u4e8e2025\u5e74\u5e74\u5e95\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u7684II\u671f\u90e8\u5206\u7684\u7814\u7a76\u8bfb\u51fa\u6570\u636e\uff0c\u8be5\u7814\u7a76\u7531\u548c\u9ec4\u533b\u836f\u7533\u529e\uff0c\u8054\u5408\u827e\u745e\u5361\u00ae\u3001\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff08nab-paclitaxel\uff09\u53ca\u5409\u897f\u4ed6\u6ee8\uff08gemcitabine\uff09\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u60a3\u8005\uff08NCT06361888\uff09\u3002<\/p>\n

\u4ed6\u6cfd\u53f8\u4ed6\uff08\u4e2d\u56fd\u5546\u54c1\u540d\uff1a\u8fbe\u552f\u73c2\u00ae\uff09\uff0c\u4e00\u79cd\u540c\u7c7b\u9996\u521bEZH2\u53e3\u670d\u6291\u5236\u5242<\/p>\n

\u8fbe\u552f\u73c2\u00ae\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\uff0c\u7528\u4e8e\u4e09\u7ebf\u6cbb\u7597\u4f34\u6709EZH2\u7a81\u53d8\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3002SYMPHONY-1\u5168\u7403\u7814\u7a76III\u671f\u90e8\u5206\u7684\u4e2d\u56fd\u90e8\u5206\u7ee7\u7eed\u5165\u7ec4\u4e2d\uff0c\u8054\u5408\u6765\u90a3\u5ea6\u80fa\uff08lenalidomide\uff09\u548c\u5229\u59a5\u6614\u5355\u6297\uff08rituximab\uff09\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\uff08NCT04224493\uff09\u3002<\/p>\n

HMPL-453\uff08fanregratinib\uff09\uff0c\u4e00\u79cd\u65b0\u578b\u3001\u9ad8\u9009\u62e9\u6027\u53ca\u5f3a\u6548\u7684FGFR 1\/2\/3\u6291\u5236\u5242<\/p>\n

\u4e8e2025\u5e742\u6708\uff0c\u4e2d\u56fdII\u671f\u6ce8\u518c\u7814\u7a76\u5b8c\u6210\u60a3\u8005\u62db\u52df\uff0c\u7528\u4e8e\u6cbb\u7597\u4f34\u6709FGFR\u878d\u5408\/\u91cd\u6392\u7684\u809d\u5185\u80c6\u7ba1\u764c\uff08NCT04353375\uff09\u3002<\/p>\n

HMPL-306\uff08ranosidenib\uff09\uff0c\u4e00\u79cdIDH1\u548cIDH2\u9176\u7684\u7814\u7a76\u6027\u9ad8\u9009\u62e9\u6027\u53e3\u670d\u53cc\u91cd\u6291\u5236\u5242<\/p>\n

RAPHAEL\u4e2d\u56fdIII\u671f\u7814\u7a76\u7ee7\u7eed\u5165\u7ec4\u4e2d\uff0c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u4f34\u6709IDH1\/2\u7a81\u53d8\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08NCT06387069\uff09\u3002<\/p>\n

IV. \u6297\u4f53\u9776\u5411\u5076\u8054\u836f\u7269\uff08ATTC\uff09\u5e73\u53f0<\/p>\n

\u81ea\u4e3b\u521b\u7acb\u7684\u5168\u65b0\u5e73\u53f0\uff0c\u5df2\u4ea7\u751f\u591a\u4e2a\u6f5c\u5728\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269<\/p>\n

\u548c\u9ec4\u533b\u836f\u8ba1\u5212\u4e8e2025\u5e74\u5e74\u5e95\u5de6\u53f3\u542f\u52a8\u9996\u6b3eATTC\u5019\u9009\u836f\u7269\u7684\u4e2d\u56fd\u53ca\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u968f\u540e\u4e8e2026\u5e74\u63d0\u4ea4\u66f4\u591aATTC\u5019\u9009\u836f\u7269\u7684\u591a\u9879\u5168\u7403\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002<\/p>\n

\u65b0\u4e00\u4ee3\u7684ATTC\u6280\u672f\u5e73\u53f0\u5145\u5206\u53d1\u6325\u4e86\u6211\u4eec\u4e8c\u5341\u591a\u5e74\u6765\u5728\u9776\u5411\u7597\u6cd5\u53ca\u5c0f\u5206\u5b50\u6291\u5236\u5242\u9886\u57df\u6240\u79ef\u7d2f\u7684\u4e13\u4e1a\u77e5\u8bc6\u3002\u901a\u8fc7\u5c06\u4e00\u7aef\u7684\u5355\u514b\u9686\u6297\u4f53\u4e0e\u53e6\u4e00\u7aef\u7684\u4e13\u5229\u9776\u5411\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff08SMI\uff09\u6709\u6548\u8f7d\u8377\uff08payload\uff09\u76f8\u8fde\u63a5\uff0c\u6211\u4eec\u7684ATTC\u5e73\u53f0\u6709\u6f5c\u529b\u521b\u9020\u51fa\u8986\u76d6\u5e7f\u6cdb\u80bf\u7624\u9002\u5e94\u75c7\u7684\u4e30\u5bcc\u7684\u5019\u9009\u836f\u7269\uff0c\u5305\u62ec\u9488\u5bf9\u7279\u5b9a\u75be\u75c5\u4e9a\u578b\u7684\u7cbe\u51c6\u7597\u6cd5\u3002\u8fd9\u4e9bATTC\u5019\u9009\u836f\u7269\u4e3a\u4e0b\u4e00\u6ce2\u4e34\u5e8a\u5f00\u53d1\u6d6a\u6f6e\u6ce8\u5165\u4e86\u65b0\u6d3b\u529b\u3002\u4e0e\u4f20\u7edf\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\u53ca\/\u6216\u5c0f\u5206\u5b50\u836f\u7269\u76f8\u6bd4\uff0c\u5177\u6709\u5173\u952e\u7684\u6f5c\u5728\u4f18\u52bf\uff1a<\/p>\n

\u901a\u8fc7\u6297\u4f53\u548c\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u7684\u534f\u540c\u7ec4\u5408\u6765\u63d0\u9ad8\u7597\u6548\uff1a\u8fd9\u4e9b\u7ec4\u5408\u5c06\u9488\u5bf9\u7279\u5b9a\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u514b\u670d\u73b0\u6709\u6cbb\u7597\u7684\u8010\u836f\u6027\u3002\u5177\u6709\u66f4\u9ad8\u7684\u5b89\u5168\u6027\u548c\u66f4\u957f\u7684\u6cbb\u7597\u65f6\u95f4\uff1a\u4e0e\u5c0f\u5206\u5b50\u76f8\u6bd4\uff0cATTC\u836f\u7269\u5177\u6709\u66f4\u4f4e\u7684\u5bf9\u80bf\u7624\u4ee5\u5916\u7ec4\u7ec7\u6bd2\u6027\u6216\u8131\u9776\u6bd2\u6027\uff0c\u4e0e\u4f20\u7edf\u7ec6\u80de\u6bd2\u7d20\u5076\u8054\u7269\u76f8\u6bd4\u9aa8\u9ad3\u6291\u5236\u98ce\u9669\u66f4\u4f4e\uff0c\u53ef\u63d0\u5347\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3002\u4f18\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u89e3\u51b3\u96be\u6210\u836f\u9776\u70b9\u56f0\u5883\uff1a\u4e0e\u53e3\u670d\u5c0f\u5206\u5b50\u6291\u5236\u5242\u76f8\u6bd4\uff0c\u6297\u4f53\u5f15\u5bfc\u7684\u9776\u5411\u9012\u9001\u4ee4\u751f\u7269\u5229\u7528\u5ea6\u63d0\u9ad8\u5e76\u51cf\u5c11\u836f\u7269\u95f4\u76f8\u4e92\u4f5c\u7528\u3002\u8f83\u73b0\u6709\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u5177\u6709\u4f18\u52bf\uff1a\u7531\u4e8eSMI\u6709\u6548\u8f7d\u8377\u5bf9\u975e\u80bf\u7624\u7ec4\u7ec7\u7684\u6bd2\u6027\u8f83\u4f4e\uff0c\u4e14\u5728\u76ee\u6807\u7ec6\u80de\u5185\u7ecf\u8fc7\u6eb6\u9176\u4f53\u88c2\u89e3\u91ca\u653e\uff0c\u56e0\u800c\u53ef\u9488\u5bf9\u80bf\u7624\u7ec6\u80de\u7279\u6709\u7684\u7531\u7a81\u53d8\u9a71\u52a8\u7684\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\u3002\u5176\u4ea6\u53ef\u4e0e\u5316\u7597\u3001\u514d\u75ab\u7597\u6cd5\u7b49\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u8054\u5408\u7528\u836f\uff0c\u63d0\u9ad8\u7597\u6548\u3002\u6f5c\u5728\u4e00\u7ebf\u5e94\u7528\u7684\u53ef\u80fd\u6027\uff1a\u65e0\u9700\u5316\u7597\u7684ATTC\u6709\u671b\u652f\u6301\u8054\u5408\u5176\u4ed6\u9776\u5411\u7597\u6cd5\u3001\u5316\u7597\u548c\u514d\u75ab\u7597\u6cd5\u5728\u66f4\u65e9\u7ebf\u6570\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u7528\u836f\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5e02\u573a\u6f5c\u529b\u3002<\/p>\n

V. \u5408\u4f5c\u6700\u65b0\u8fdb\u5c55<\/p>\n

\u548c\u9ec4\u533b\u836f\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269IMG-007\u53d6\u5f97\u8fdb\u4e00\u6b65\u8fdb\u5c55<\/p>\n

ImageneBio, Inc.\uff08\u7eb3\u65af\u8fbe\u514b\uff1aIMA\uff09- \u521b\u54cd\u751f\u7269\uff08Inmagene\uff09\u548cIkena Oncology, Inc.\u4e8e2025\u5e747\u670825\u65e5\u5b8c\u6210\u5408\u5e76\u3002\u5408\u5e76\u540e\u7684\u516c\u53f8ImageneBio, Inc.\u6301\u6709\u548c\u9ec4\u533b\u836f\u6388\u4e88\u7684IMG-007\u7684\u8bb8\u53ef\u6743\u76ca\u3002\u548c\u9ec4\u533b\u836f\u62e5\u6709ImageneBio, Inc.\u7684\u7ea63.67%\u7684\u80a1\u4efd\u3002\u4e8e2025\u5e744\u6708\uff0cIMG-007\u7528\u4e8e\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u7684\u7f8e\u56fd\/\u52a0\u62ff\u5927IIa\u671f\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\u516c\u5e03\uff0c\u7ed3\u679c\u663e\u793a\u7b2c16\u5468\u7684EASI\u8bc4\u5206\u7684\u5e73\u5747\u53d8\u5316\u4e3a77%\uff0cEASI-75\u5e94\u7b54\u7387\u4e3a54%\uff08NCT05984784\uff09\u3002\u4e8e2025\u5e747\u6708\uff0c\u4e00\u9879\u9488\u5bf9\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u7279\u5e94\u6027\u76ae\u708e\u60a3\u8005\u7684IMG-007\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u7f8e\u56fdIIb\u671f\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u5b8c\u6210\u9996\u540d\u60a3\u8005\u7ed9\u836f\uff0c\u7814\u7a76\u8ba1\u5212\u5165\u7ec4220\u540d\u5bf9\u5c40\u90e8\u6cbb\u7597\u53cd\u5e94\u4e0d\u5145\u5206\u53ca\/\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\uff08NCT07037901\uff09\u3002\u4e8e2025\u5e741\u6708\uff0cIMG-007\u7528\u4e8e\u6cbb\u7597\u91cd\u5ea6\u6591\u79c3\u7684\u7f8e\u56fd\/\u52a0\u62ff\u5927IIa\u671f\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\u516c\u5e03\uff0c\u7ed3\u679c\u663e\u793a\u7b2c36\u5468\u65f6\uff0c\u6591\u79c3\u4e25\u91cd\u7a0b\u5ea6\u8bc4\u5206\u5de5\u5177\uff08SALT\uff09\u8bc4\u5206\u5e73\u5747\u964d\u4f4e30.1%\uff08NCT06060977\uff09\u3002<\/p>\n

VI. \u5176\u4ed6\u4e1a\u52a1<\/p>\n

\u5176\u4ed6\u4e1a\u52a1\u7efc\u5408\u6536\u5165\u4e3b\u8981\u6765\u81ea\u6211\u4eec\u5728\u4e2d\u56fd\u7684\u5904\u65b9\u836f\u5206\u9500\u4e1a\u52a1\uff0c\u622a\u81f32025\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u4fdd\u6301\u7a33\u5b9a\uff0c\u4e3a1.342\u4ebf\u7f8e\u5143\u3002\u548c\u9ec4\u533b\u836f\u4e8e2025\u5e744\u6708\u4ee56.085\u4ebf\u7f8e\u5143\u73b0\u91d1\u51fa\u552e\u4e8e\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u768445.0%\u80a1\u6743\uff0c\u5e76\u4fdd\u75595.0%\u7684\u80a1\u6743\u30022025\u5e74\u4e0a\u534a\u5e74\u5df2\u786e\u8ba4\u7a0e\u540e\u51fa\u552e\u51c0\u6536\u76ca4.163\u4ebf\u7f8e\u5143\u3002\u622a\u81f32025\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u548c\u9ec4\u533b\u836f\u5e94\u5360\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u7684\u80a1\u6743\u6536\u76ca\u51cf\u5c11\u81f32,310\u4e07\u7f8e\u5143\u3002\u548c\u9ec4\u533b\u836f\u5e94\u5360\u5176\u4ed6\u4e1a\u52a1\u7684\u7efc\u5408\u51c0\u6536\u76ca\u589e\u52a0\u81f34.403\u4ebf\u7f8e\u5143\uff082024\u5e74\u4e0a\u534a\u5e74\uff1a3,410\u4e07\u7f8e\u5143\uff09\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u51fa\u552e\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u80a1\u6743\u3002<\/p>\n

VII. \u53ef\u6301\u7eed\u53d1\u5c55<\/p>\n

\u548c\u9ec4\u533b\u836f\u4e8e2025\u5e744\u6708\u53d1\u5e03\u4e86\u300a2024\u5e74\u53ef\u6301\u7eed\u53d1\u5c55\u62a5\u544a<\/a>\u300b\uff0c\u91cd\u70b9\u62ab\u9732\u4e86\u548c\u9ec4\u533b\u836f\u572811\u4e2a\u76ee\u6807\u53ca\u6307\u6807\u65b9\u9762\u7684\u8fdb\u5c55\uff0c\u5e76\u9610\u8ff0\u4e86\u6c14\u5019\u884c\u52a8\u76f8\u5173\u7684\u5f3a\u5316\u5de5\u4f5c\uff0c\u5305\u62ec\u63d0\u5347\u8303\u56f43\u6570\u636e\u8d28\u91cf\u3001\u52a0\u5f3a\u5bf9\u822a\u7a7a\u5dee\u65c5\u7684\u76d1\u63a7\uff0c\u4ee5\u53ca\u589e\u52a0\u4e0e\u4f9b\u5e94\u5546\u4e92\u52a8\u7b49\u3002\u4eca\u5e74\uff0c\u548c\u9ec4\u533b\u836f\u8fdb\u884c\u4e86\u4e00\u9879\u5168\u9762\u7684\u6c14\u5019\u98ce\u9669\u8bc4\u4f30\uff0c\u4ee5\u8fdb\u4e00\u6b65\u4e86\u89e3\u5e76\u91cf\u5316\u6c14\u5019\u53d8\u5316\u53ef\u80fd\u5e26\u6765\u7684\u6f5c\u5728\u8d22\u52a1\u5f71\u54cd\uff0c\u5305\u62ec\u6d2a\u6c34\u53ca\u9ad8\u6e29\u538b\u529b\u5e26\u6765\u7684\u5b9e\u4f53\u98ce\u9669\uff0c\u4ee5\u53ca\u548c\u9ec4\u533b\u836f\u5728\u4e50\u89c2\u53ca\u60b2\u89c2\u60c5\u51b5\u4e0b\u6240\u9762\u4e34\u7684\u8f6c\u578b\u98ce\u9669\u3002<\/p>\n

\u548c\u9ec4\u533b\u836f\u5728ESG\u8bc4\u7ea7\u65b9\u9762\u6301\u7eed\u53d6\u5f97\u663e\u8457\u8fdb\u5c55\uff0c\u5305\u62ec\u6765\u81eaCDP Worldwide\u3001\u6052\u751f\u53ef\u6301\u7eed\u53d1\u5c55\u4f01\u4e1a\u6307\u6570\u7cfb\u5217\u3001ISS ESG\u3001MSCI ESG\u3001Sustainalytics\u53caS&P Global ESG\u7b49\u7684\u8bc4\u7ea7\u3002\u4e8e2025\u5e745\u6708\uff0c\u548c\u9ec4\u533b\u836f\u66f4\u4e8eExtel\u4e9a\u6d32\u7ba1\u7406\u56e2\u961f\u8c03\u7814\u4e2d\uff0c\u4f4d\u5217\u533b\u7597\u4fdd\u5065\u3001\u5236\u836f\u53ca\u751f\u7269\u79d1\u6280\u884c\u4e1a\u7684”\u6700\u4f73ESG”\u6392\u540d\u7b2c\u4e09\uff0c\u53cd\u6620\u903e5,400\u540d\u6295\u8d44\u7ec4\u5408\u7ecf\u7406\u53ca\u5206\u6790\u5e08\u7684\u53cd\u9988\u3002\u548c\u9ec4\u533b\u836f\u83b7Extel\u5217\u4e3a”\u6700\u53d7\u5c0a\u656c\u516c\u53f8”\u4e4b\u4e00\uff1b\u5728\u533b\u7597\u4fdd\u5065\u3001\u5236\u836f\u53ca\u751f\u7269\u79d1\u6280\u884c\u4e1a\u5185\uff0c\u548c\u9ec4\u533b\u836f\u5728\u4ee5\u4e0b\u9879\u76ee\u4e2d\u6392\u540d\u7b2c\u4e00\uff1a\u516c\u53f8\u8463\u4e8b\u4f1a\u3001\u6700\u4f73\u9996\u5e2d\u6267\u884c\u5b98\u3001\u6700\u4f73\u6295\u8d44\u8005\u5173\u7cfb\u9879\u76ee\u3001\u6700\u4f73\u6295\u8d44\u8005\u5173\u7cfb\u4e13\u4e1a\u4eba\u58eb\uff1b\u5728\u4ee5\u4e0b\u9879\u76ee\u4e2d\u6392\u540d\u7b2c\u4e8c\uff1a\u6700\u4f73\u9996\u5e2d\u8d22\u52a1\u5b98\u3001\u6700\u4f73\u6295\u8d44\u8005\u5173\u7cfb\u56e2\u961f\u3002<\/p>\n

\u8d22\u52a1\u6458\u8981\u00a0<\/p>\n

\u622a\u81f32025\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u6536\u5165\u4e3a2.777\u4ebf\u7f8e\u5143\uff0c\u800c\u622a\u81f32024\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u4e3a3.057\u4ebf\u7f8e\u5143\u3002<\/p>\n

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\u4e8e2025\u5e746\u670830\u65e5\uff0c\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u548c\u77ed\u671f\u6295\u8d44\u5408\u8ba1\u4e3a13.645\u4ebf\u7f8e\u5143\uff0c\u800c\u4e8e2024\u5e7412\u670831\u65e5\u5219\u4e3a8.361\u4ebf\u7f8e\u5143\u3002<\/p>\n

\u4e8e2025\u5e74\u4e0a\u534a\u5e74\uff0c\u4e0d\u5305\u62ec\u878d\u8d44\u6d3b\u52a8\u7684\u8c03\u6574\u540e\u7684\u96c6\u56e2\uff08\u975eGAAP\uff09\u51c0\u73b0\u91d1\u6d41\u5165\u4e3a5.191\u4ebf\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u51fa\u552e\u90e8\u5206\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u6240\u5f97\u6b3e\u9879\u603b\u989d6.085\u4ebf\u7f8e\u5143\uff0c\u88ab\u51fa\u552e\u90e8\u5206\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u652f\u4ed8\u7684\u8d44\u672c\u589e\u503c\u7a0e\u6b3e5,950\u4e07\u7f8e\u5143\u3001\u652f\u4ed81,000\u4e07\u7f8e\u5143\u7684\u76d1\u7ba1\u83b7\u6279\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca920\u4e07\u7f8e\u5143\u7684\u8d44\u672c\u5f00\u652f\u6240\u62b5\u9500\uff082024\u5e74\u4e0a\u534a\u5e74\uff1a-5,130\u4e07\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u7ecf\u8425\u6d3b\u52a8\u6240\u7528\u73b0\u91d1\u51c0\u989d3,980\u4e07\u7f8e\u5143\u53ca\u8d44\u672c\u5f00\u652f1,010\u4e07\u7f8e\u5143\uff09\u3002\u4e8e2025\u5e74\u4e0a\u534a\u5e74\uff0c\u878d\u8d44\u6d3b\u52a8\u6240\u5f97\u73b0\u91d1\u51c0\u989d\u5408\u8ba1\u4e3a930\u4e07\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u63d0\u53d6\u94f6\u884c\u501f\u6b3e820\u4e07\u7f8e\u5143\uff082024\u5e74\u4e0a\u534a\u5e74\uff1a\u878d\u8d44\u6d3b\u52a8\u6240\u7528\u73b0\u91d1\u51c0\u989d3,260\u4e07\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u8d2d\u4e70\u4e863,610\u4e07\u7f8e\u5143\u7684\u80a1\u6743\u5956\u52b1\uff09\u3002<\/p>\n

\u6c47\u7387\u5f71\u54cd\uff1a2025\u5e74\u4e0a\u534a\u5e74\uff0c\u4eba\u6c11\u5e01\u5151\u7f8e\u5143\u5e73\u5747\u8d2c\u503c\u7ea60.8%\uff0c\u8fd9\u5f71\u54cd\u4e86\u6211\u4eec\u7684\u7efc\u5408\u8d22\u52a1\u4e1a\u7ee9\u3002<\/p>\n

\u8d22\u52a1\u6307\u5f15
\u548c\u9ec4\u533b\u836f\u66f4\u65b0\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u7efc\u5408\u6536\u5165\u76842025\u5e74\u5168\u5e74\u6307\u5f15\u81f32.7\u4ebf\u7f8e\u5143\u81f33.5\u4ebf\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u6765\u81ea\u5408\u4f5c\u4f19\u4f34\u7684\u91cc\u7a0b\u7891\u6536\u5165\u5ef6\u540e\u81f32026\u5e74\u53ca\u4ee5\u540e\uff0c\u4ee5\u53ca\u7d22\u4e50\u5339\u5c3c\u5e03\u5728\u4e2d\u56fd\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5ba1\u8bc4\u9884\u8ba1\u5b8c\u6210\u65f6\u95f4\u63a8\u8fdf\u81f32025\u5e74\u540e\u3002\u548c\u9ec4\u533b\u836f\u5c06\u5145\u5206\u5229\u7528\u5176\u5f3a\u5927\u7684\u73b0\u91d1\u8d44\u6e90\uff0c\u52a0\u901fATTC\u9879\u76ee\u7684\u5168\u7403\u5f00\u53d1\u5e76\u63a2\u7d22\u6295\u8d44\u673a\u4f1a\u3002<\/p>\n

\u80a1\u4e1c\u53ca\u6295\u8d44\u8005\u5e94\u6ce8\u610f\uff1a<\/p>\n

\u672c\u516c\u53f8\u4e0d\u4fdd\u8bc1\u8d22\u52a1\u6307\u5f15\u4e2d\u5305\u542b\u7684\u9648\u8ff0\u5c06\u5b9e\u73b0\uff0c\u6216\u5176\u4e2d\u5305\u542b\u7684\u8d22\u52a1\u4e1a\u7ee9\u5c06\u5b9e\u73b0\u6216\u53ef\u80fd\u5b9e\u73b0\uff1b\u53ca\u672c\u516c\u53f8\u8fc7\u53bb\u66fe\u4fee\u8ba2\u6211\u4eec\u7684\u8d22\u52a1\u6307\u5f15\uff0c\u56e0\u6b64\u5e94\u53c2\u8003\u6211\u4eec\u5728\u672c\u516c\u544a\u520a\u53d1\u65e5\u671f\u540e\u5c31\u4efb\u4f55\u8d22\u52a1\u6307\u5f15\u66f4\u65b0\u7684\u516c\u544a\u3002<\/p>\n

\u2014\u2014\u2014<\/p>\n

\u975eGAAP\u8d22\u52a1\u6307\u6807\u7684\u4f7f\u7528\u548c\u8c03\u8282\u00a0\u2014 \u672c\u516c\u544a\u4e2d\u63d0\u53ca\u4e0d\u5305\u62ec\u878d\u8d44\u6d3b\u52a8\u7684\u8c03\u6574\u540e\u96c6\u56e2\u51c0\u73b0\u91d1\u6d41\u53ca\u6309\u7167\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u62a5\u544a\u7684\u8d22\u52a1\u6307\u6807\u5747\u57fa\u4e8e\u975eGAAP\u8d22\u52a1\u6307\u6807\u3002\u8bf7\u53c2\u9605”\u975eGAAP\u8d22\u52a1\u6307\u6807\u7684\u4f7f\u7528\u548c\u8c03\u8282”\uff0c\u4ee5\u5206\u522b\u4e86\u89e3\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u7684\u89e3\u91ca\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u4e0e\u6700\u5177\u53ef\u6bd4\u6027\u7684GAAP\u6307\u6807\u8c03\u8282\u7684\u8fdb\u4e00\u6b65\u8d44\u6599\u3002<\/p>\n

\u2014\u2014\u2014<\/p>\n

\u8d22\u52a1\u6982\u8981<\/p>\n

\u7b80\u660e\u7efc\u5408\u8d44\u4ea7\u8d1f\u503a\u8868\u6570\u636e<\/p>\n

\n

\uff08\u5343\u7f8e\u5143\uff09<\/span><\/p>\n

\u4e8e<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5<\/span><\/span><\/p>\n

<\/p>\n

\u4e8e<\/span>2024<\/span>\u5e74<\/span>12<\/span>\u6708<\/span>31<\/span>\u65e5<\/span><\/span><\/p>\n

<\/p>\n

\uff08\u672a\u7ecf\u5ba1\u6838\uff09<\/span><\/p>\n

\u8d44\u4ea7<\/span><\/span><\/p>\n

<\/p>\n

\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u548c\u77ed\u671f\u6295\u8d44<\/span><\/p>\n

1,364,520<\/span><\/p>\n

<\/p>\n

836,110<\/span><\/p>\n

\u5e94\u6536\u8d26\u6b3e<\/span><\/p>\n

146,967<\/span><\/p>\n

<\/p>\n

155,537<\/span><\/p>\n

\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n

80,840<\/span><\/p>\n

<\/p>\n

74,908<\/span><\/p>\n

\u7269\u4e1a\u3001\u5382\u623f\u53ca\u8bbe\u5907<\/span><\/p>\n

94,573<\/span><\/p>\n

<\/p>\n

92,498<\/span><\/p>\n

\u4e00\u5bb6\u5408\u8d44\u4f01\u4e1a\u6743\u76ca<\/span><\/p>\n

3,645<\/span><\/p>\n

<\/p>\n

77,765<\/span><\/p>\n

\u5176\u4ed6\u975e\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n

85,395<\/span><\/p>\n

<\/p>\n

37,378<\/span><\/p>\n

\u8d44\u4ea7\u603b\u989d<\/span><\/span><\/p>\n

1,775,940<\/span><\/p>\n

<\/p>\n

1,274,196<\/span><\/p>\n

\u8d1f\u503a\u53ca\u80a1\u4e1c\u6743\u76ca<\/span><\/span><\/p>\n

<\/p>\n

\u5e94\u4ed8\u8d26\u6b3e<\/span><\/p>\n

43,725<\/span><\/p>\n

<\/p>\n

42,521<\/span><\/p>\n

\u5176\u4ed6\u5e94\u4ed8\u6b3e\u3001\u5e94\u8ba1\u5f00\u652f\u53ca\u9884\u6536\u6b3e\u9879<\/span><\/p>\n

221,061<\/span><\/p>\n

<\/p>\n

256,124<\/span><\/p>\n

\u9012\u5ef6\u6536\u5165<\/span><\/p>\n

77,628<\/span><\/p>\n

<\/p>\n

98,503<\/span><\/p>\n

\u94f6\u884c\u8d37\u6b3e\u00a0<\/span><\/p>\n

93,444<\/span><\/p>\n

<\/p>\n

82,806<\/span><\/p>\n

\u5176\u4ed6\u8d1f\u503a<\/span><\/p>\n

98,159<\/span><\/p>\n

<\/p>\n

22,389<\/span><\/p>\n

\u8d1f\u503a\u603b\u989d<\/span><\/span><\/p>\n

534,017<\/span><\/p>\n

<\/p>\n

502,343<\/span><\/p>\n

\u672c\u516c\u53f8\u80a1\u4e1c\u6743\u76ca<\/span><\/span><\/p>\n

1,229,064<\/span><\/p>\n

<\/p>\n

759,929<\/span><\/p>\n

\u975e\u63a7\u80a1\u6743\u76ca<\/span><\/p>\n

12,859<\/span><\/p>\n

<\/p>\n

11,924<\/span><\/p>\n

\u8d1f\u503a\u53ca\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/span><\/span><\/p>\n

1,775,940<\/span><\/p>\n

<\/p>\n

1,274,196<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

\n

\u7b80\u660e\u7efc\u5408\u7ecf\u8425\u8868\u6570\u636e<\/span><\/span><\/p>\n

\uff08\u672a\u7ecf\u5ba1\u6838\uff0c\u5343\u7f8e\u5143\uff0c\u80a1\u4efd\u548c\u6bcf\u80a1\u6570\u636e\u9664\u5916\uff09<\/span><\/p>\n

\u622a\u81f3<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u4e2a\u6708<\/span><\/span><\/p>\n

<\/p>\n

2025<\/span>\u5e74<\/span><\/span><\/p>\n

<\/p>\n

2024<\/span>\u5e74<\/span><\/span><\/p>\n

\u6536\u5165\uff1a<\/span><\/span><\/p>\n

<\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u2014\u4e0a\u5e02\u4ea7\u54c1<\/span><\/p>\n

99,039<\/span><\/p>\n

<\/p>\n

127,796<\/span><\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u2014\u7814\u53d1<\/span><\/p>\n

44,408<\/span><\/p>\n

<\/p>\n

40,841<\/span><\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u7efc\u5408\u6536\u5165<\/span><\/p>\n

143,447<\/span><\/p>\n

<\/p>\n

168,637<\/span><\/p>\n

\u5176\u4ed6\u4e1a\u52a1<\/span><\/p>\n

134,230<\/span><\/p>\n

<\/p>\n

137,044<\/span><\/p>\n

\u6536\u5165\u603b\u989d<\/span><\/span><\/p>\n

277,677<\/span><\/p>\n

<\/p>\n

305,681<\/span><\/p>\n

\u7ecf\u8425\u5f00\u652f\uff1a<\/span><\/span><\/p>\n

<\/p>\n

\u6536\u5165\u6210\u672c<\/span><\/p>\n

(167,577)<\/span><\/p>\n

<\/p>\n

(180,135)<\/span><\/p>\n

\u7814\u53d1\u5f00\u652f<\/span><\/p>\n

(71,990)<\/span><\/p>\n

<\/p>\n

(95,256)<\/span><\/p>\n

\u9500\u552e\u53ca\u884c\u653f\u5f00\u652f<\/span><\/p>\n

(41,624)<\/span><\/p>\n

<\/p>\n

(57,811)<\/span><\/p>\n

\u7ecf\u8425\u5f00\u652f\u603b\u989d<\/span><\/span><\/p>\n

(281,191)<\/span><\/p>\n

<\/p>\n

(333,202)<\/span><\/p>\n

<\/p>\n

(3,514)<\/span><\/p>\n

<\/p>\n

(27,521)<\/span><\/p>\n

\u51fa\u552e\u4e00\u5bb6\u5408\u8d44\u4f01\u4e1a\u6536\u76ca<\/span><\/p>\n

477,456<\/span><\/p>\n

<\/p>\n

\u2014<\/span><\/p>\n

\u5176\u4ed6\u6536\u76ca\u51c0\u989d<\/span><\/p>\n

21,650<\/span><\/p>\n

<\/p>\n

22,765<\/span><\/p>\n

\u9664\u6240\u5f97\u7a0e\u5f00\u652f\u53ca\u6240\u5360\u4e00\u5bb6\u5408\u8d44\u4f01\u4e1a\u6743\u76ca\u6536\u76ca\u524d\u6536\u76ca<\/span>\/<\/span>\uff08\u4e8f\u635f\uff09<\/span><\/span><\/p>\n

495,592<\/span><\/p>\n

<\/p>\n

(4,756)<\/span><\/p>\n

\u00a0\u00a0 \u6240\u5f97\u7a0e\u5f00\u652f<\/span><\/p>\n

(2,029)<\/span><\/p>\n

<\/p>\n

(2,886)<\/span><\/p>\n

\u6240\u5f97\u7a0e\u5f00\u652f\u2014\u51fa\u552e\u4e00\u5bb6\u5408\u8d44\u4f01\u4e1a<\/span><\/p>\n

(61,133)<\/span><\/p>\n

<\/p>\n

\u2014<\/span><\/p>\n

\u6240\u5360\u4e00\u5bb6\u5408\u8d44\u4f01\u4e1a\u6743\u76ca\u9664\u7a0e\u540e\u6536\u76ca<\/span><\/p>\n

23,125<\/span><\/p>\n

<\/p>\n

33,807<\/span><\/p>\n

\u51c0\u6536\u76ca<\/span><\/span><\/p>\n

455,555<\/span><\/p>\n

<\/p>\n

26,165<\/span><\/p>\n

\u51cf\uff1a\u975e\u63a7\u80a1\u6743\u76ca\u5e94\u5360\u51c0\u6536\u76ca<\/span><\/p>\n

(601)<\/span><\/p>\n

<\/p>\n

(364)<\/span><\/p>\n

\u548c\u9ec4\u533b\u836f\u5e94\u5360\u51c0\u6536\u76ca<\/span><\/span><\/p>\n

454,954<\/span><\/p>\n

<\/p>\n

25,801<\/span><\/p>\n

\u548c\u9ec4\u533b\u836f\u5e94\u5360\u6bcf\u80a1\u666e\u901a\u80a1\u76c8\u5229\uff08\u6bcf\u80a1\u666e\u901a\u80a1\uff0c\u7f8e\u5143\uff09<\/span><\/span><\/p>\n

<\/p>\n

\u2014<\/span>\u57fa\u672c<\/span>\u00a0<\/span><\/p>\n

0.53<\/span><\/p>\n

<\/p>\n

0.03<\/span><\/p>\n

\u2014<\/span>\u644a\u8584<\/span><\/span><\/p>\n

0.52<\/span><\/p>\n

<\/p>\n

0.03<\/span><\/p>\n

\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u76c8\u5229\u6240\u7528\u80a1\u6570\u00a0<\/span><\/p>\n

<\/p>\n

\u2014\u57fa\u672c<\/span><\/p>\n

857,038,725<\/span><\/p>\n

<\/p>\n

856,030,704<\/span><\/p>\n

\u2014\u644a\u8584<\/span><\/p>\n

872,564,513<\/span><\/p>\n

<\/p>\n

872,534,466<\/span><\/p>\n

\u548c\u9ec4\u533b\u836f\u5e94\u5360\u6bcf\u4efd<\/span>ADS<\/span>\u76c8\u5229\uff08\u6bcf\u4efd<\/span>ADS<\/span>\uff0c\u7f8e\u5143\uff09<\/span><\/span><\/p>\n

<\/p>\n

\u2014<\/span>\u57fa\u672c<\/span>\u00a0<\/span><\/p>\n

2.65<\/span><\/p>\n

<\/p>\n

0.15<\/span><\/p>\n

\u2014<\/span>\u644a\u8584<\/span><\/span><\/p>\n

2.61<\/span><\/p>\n

<\/p>\n

0.15<\/span><\/p>\n

\u8ba1\u7b97\u6bcf\u4efdADS\u76c8\u5229\u6240\u7528\u7684ADS\u4efd\u6570<\/span><\/p>\n

<\/p>\n

\u2014\u57fa\u672c<\/span><\/p>\n

171,407,745<\/span><\/p>\n

<\/p>\n

171,206,141<\/span><\/p>\n

\u2014\u644a\u8584<\/span><\/p>\n

174,512,903<\/span><\/p>\n

<\/p>\n

174,506,893<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

\u5173\u4e8e\u548c\u9ec4\u533b\u836f
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\u5185\u5e55\u6d88\u606f
\u672c\u516c\u544a\u5305\u542b\uff08\u6b27\u76df\uff09\u7b2c596\/2014\u53f7\u6761\u4f8b\uff08\u8be5\u6761\u4f8b\u6784\u6210\u300a2018\u5e74\u6b27\u6d32\u8054\u76df\uff08\u9000\u51fa\uff09\u6cd5\u300b\u5b9a\u4e49\u7684\u6b27\u76df\u4fdd\u7559\u6cd5\u5f8b\u7684\u4e00\u90e8\u5206\uff09\u7b2c7\u6761\u89c4\u5b9a\u7684\u5185\u5e55\u6d88\u606f\u3002<\/p>\n

\u533b\u7597\u4fe1\u606f
\u672c\u516c\u544a\u6240\u63d0\u5230\u7684\u4ea7\u54c1\u53ef\u80fd\u5e76\u672a\u5728\u6240\u6709\u56fd\u5bb6\u4e0a\u5e02\uff0c\u6216\u53ef\u80fd\u4ee5\u4e0d\u540c\u7684\u5546\u6807\u8fdb\u884c\u9500\u552e\uff0c\u6216\u7528\u4e8e\u4e0d\u540c\u7684\u75c5\u75c7\uff0c\u6216\u91c7\u7528\u4e0d\u540c\u7684\u5242\u91cf\uff0c\u6216\u62e5\u6709\u4e0d\u540c\u7684\u6548\u529b\u3002\u672c\u6587\u4e2d\u6240\u5305\u542b\u7684\u4efb\u4f55\u4fe1\u606f\u90fd\u4e0d\u5e94\u88ab\u89c6\u4e3a\u662f\u4efb\u4f55\u5904\u65b9\u836f\u7684\u7533\u8bf7\u3001\u63a8\u5e7f\u6216\u5e7f\u544a\uff0c\u5305\u62ec\u90a3\u4e9b\u6b63\u5728\u7814\u53d1\u7684\u836f\u7269\u3002<\/p>\n

\u8bcd\u6c47\u8868<\/p>\n

\n

1L<\/span><\/p>\n

=<\/span><\/p>\n

\u4e00\u7ebf\u00a0(First-line)<\/span><\/p>\n

2L<\/span><\/p>\n

=<\/span><\/p>\n

\u4e8c\u7ebf\u00a0(Second-line)<\/span><\/p>\n

3L<\/span><\/p>\n

=<\/span><\/p>\n

\u4e09\u7ebf\u00a0(Third-line)<\/span><\/p>\n

AACR<\/span><\/p>\n

=<\/span><\/p>\n

\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u00a0(American Association for Cancer Research)<\/span><\/p>\n

ADC<\/span><\/p>\n

=<\/span><\/p>\n

\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u00a0(Antibody-drug conjugate)<\/span><\/p>\n

ADS<\/span><\/p>\n

=<\/span><\/p>\n

\u7f8e\u56fd\u9884\u6258\u8bc1\u5238\u00a0(American depositary shares)\uff0c\u6bcf\u4e00\u4efd\u4ee3\u8868\u4e94\u80a1\u666e\u901a\u80a1<\/span><\/p>\n

AIHA<\/span><\/p>\n

=<\/span><\/p>\n

\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u00a0(Autoimmune hemolytic anemia)<\/span><\/p>\n

AKT<\/span><\/p>\n

=<\/span><\/p>\n

\u86cb\u767d\u6fc0\u9176B (Protein kinase B)<\/span><\/p>\n

AML<\/span><\/p>\n

=<\/span><\/p>\n

\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u00a0(Acute myeloid leukemia)<\/span><\/p>\n

ASCO<\/span><\/p>\n

=<\/span><\/p>\n

\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u00a0(American Society of Clinical Oncology)<\/span><\/p>\n

ASH<\/span><\/p>\n

=<\/span><\/p>\n

\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u00a0(American Society of Hematology)<\/span><\/p>\n

\u963f\u65af\u5229\u5eb7\u00a0(AstraZeneca)<\/span><\/p>\n

=<\/span><\/p>\n

AstraZeneca AB, AstraZeneca PLC \u7684\u9644\u5c5e\u516c\u53f8<\/span><\/p>\n

ATTC<\/span><\/p>\n

=<\/span><\/p>\n

\u6297\u4f53\u9776\u5411\u5076\u8054\u836f\u7269\u00a0(Antibody-targeted therapy conjugates)<\/span><\/p>\n

BICR<\/span><\/p>\n

=<\/span><\/p>\n

\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u4f30\u00a0(Blinded independent central review)<\/span><\/p>\n

\u4e2d\u56fd\u94f6\u884c\u00a0(BOC)<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u56fd\u94f6\u884c\u80a1\u4efd\u6709\u9650\u516c\u53f8\u00a0(Bank of China Limited)<\/span><\/p>\n

BTK<\/span><\/p>\n

=<\/span><\/p>\n

\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u00a0(Bruton’s tyrosine kinase)<\/span><\/p>\n

CDP Worldwide<\/span><\/p>\n

=<\/span><\/p>\n

\u524d\u8eab\u4e3a\u78b3\u63ed\u9732\u8ba1\u5212\u00a0(Carbon Disclosure Project)<\/span><\/p>\n

\u56fa\u5b9a\u6c47\u7387\u00a0(CER)<\/span><\/p>\n

=<\/span><\/p>\n

\u6211\u4eec\u4ea6\u62a5\u544a\u6309\u56fa\u5b9a\u6c47\u7387\u00a0(CER)\uff0c\u4e00\u79cd\u975eGAAP\u6307\u6807\uff0c\u8ba1\u7b97\u4e1a\u7ee9\u53d8\u5316\u3002\u8bf7\u53c2\u9605”\u975eGAAP\u8d22\u52a1\u6307\u6807\u7684\u4f7f\u7528\u548c\u8c03\u8282”\uff0c\u4ee5\u5206\u522b\u4e86\u89e3\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u7684\u89e3\u91ca\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u4e0e\u6700\u5177\u53ef\u6bd4\u6027\u7684GAAP\u6307\u6807\u7684\u5bf9\u8d26\u3002<\/span><\/p>\n

CLL<\/span><\/p>\n

=<\/span><\/p>\n

\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u00a0(Chronic lymphocytic leukemia)<\/span><\/p>\n

CNS<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u00a0(Central nervous system)<\/span><\/p>\n

CR+CRh<\/span><\/p>\n

=<\/span><\/p>\n

\u7efc\u5408\u5b8c\u5168\u7f13\u89e3\u6216\u5b8c\u5168\u7f13\u89e3\u4f34\u90e8\u5206\u8840\u6db2\u5b66\u7f13\u89e3\u00a0(Combined complete remission + complete remission with partial hematologic recovery)<\/span><\/p>\n

CRC<\/span><\/p>\n

=<\/span><\/p>\n

\u7ed3\u76f4\u80a0\u764c\u00a0(Colorectal cancer)<\/span><\/p>\n

CSF-1R<\/span><\/p>\n

=<\/span><\/p>\n

\u96c6\u843d\u523a\u6fc0\u56e0\u5b50-1\u53d7\u4f53\u00a0(Colony-stimulating factor 1 receptor)<\/span><\/p>\n

DCR<\/span><\/p>\n

=<\/span><\/p>\n

\u75be\u75c5\u63a7\u5236\u7387\u00a0(Disease control rate)<\/span><\/p>\n

DLBCL<\/span><\/p>\n

=<\/span><\/p>\n

\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u00a0(Diffuse large B-cell lymphoma)<\/span><\/p>\n

DoR<\/span><\/p>\n

=<\/span><\/p>\n

\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u00a0(Duration of response)<\/span><\/p>\n

EASI<\/span><\/p>\n

=<\/span><\/p>\n

\u6e7f\u75b9\u9762\u79ef\u548c\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\u00a0(Eczema area and severity index)<\/span><\/p>\n

EGFR<\/span><\/p>\n

=<\/span><\/p>\n

\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u00a0(Epidermal growth factor receptor)<\/span><\/p>\n

EGFR\u7a81\u53d8\u00a0(EGFRm)<\/span><\/p>\n

=<\/span><\/p>\n

\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7a81\u53d8\u00a0(Epidermal growth factor receptor mutated)<\/span><\/p>\n

EHA<\/span><\/p>\n

=<\/span><\/p>\n

\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\u00a0(European Hematology Association)<\/span><\/p>\n

ELCC<\/span><\/p>\n

=<\/span><\/p>\n

\u6b27\u6d32\u80ba\u764c\u5927\u4f1a\u00a0(The European Lung Cancer\u00a0Congress)<\/span><\/p>\n

\u793c\u6765\u00a0(Eli Lilly)<\/span><\/p>\n

=<\/span><\/p>\n

Lilly (Shanghai) Management Company Limited<\/span><\/p>\n

EMC<\/span><\/p>\n

=<\/span><\/p>\n

\u5b50\u5bab\u5185\u819c\u764c\u00a0(Endometrial cancer)<\/span><\/p>\n

epNET<\/span><\/p>\n

=<\/span><\/p>\n

\u975e\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u00a0(Extra-pancreatic neuroendocrine tumor)<\/span><\/p>\n

Epizyme<\/span><\/p>\n

=<\/span><\/p>\n

Epizyme, Inc.\uff0cIpsen\u65d7\u4e0b\u516c\u53f8<\/span><\/p>\n

ERK<\/span><\/p>\n

=<\/span><\/p>\n

\u7ec6\u80de\u5916\u4fe1\u53f7\u8c03\u8282\u6fc0\u9176\u00a0(Extracellular signal-regulated kinase)<\/span><\/p>\n

ESG<\/span><\/p>\n

=<\/span><\/p>\n

\u73af\u5883\u3001\u793e\u4f1a\u53ca\u7ba1\u6cbb\u00a0(Environmental, Social and Governance)<\/span><\/p>\n

ESMO<\/span><\/p>\n

=<\/span><\/p>\n

\u6b27\u6d32\u80bf\u7624\u5b66\u4f1a\u00a0(European Society for Medical Oncology)<\/span><\/p>\n

EZH2<\/span><\/p>\n

=<\/span><\/p>\n

zeste\u57fa\u56e0\u589e\u5f3a\u5b50\u540c\u6e90\u72692 (Enhancer of zeste homolog 2)<\/span><\/p>\n

EZH2\u7a81\u53d8\u00a0(EZH2m)<\/span><\/p>\n

=<\/span><\/p>\n

zeste\u57fa\u56e0\u589e\u5f3a\u5b50\u540c\u6e90\u72692\u7a81\u53d8\u00a0(Enhancer of zeste homolog 2 mutated)<\/span><\/p>\n

FDA<\/span><\/p>\n

=<\/span><\/p>\n

\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u00a0(Food and Drug Administration)<\/span><\/p>\n

FGFR<\/span><\/p>\n

=<\/span><\/p>\n

\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u00a0(Fibroblast growth factor receptor)<\/span><\/p>\n

FLT3<\/span><\/p>\n

=<\/span><\/p>\n

FMS\u6837\u916a\u6c28\u9178\u6fc0\u91763 (FMS-like tyrosine kinase 3)<\/span><\/p>\n

GAAP<\/span><\/p>\n

=<\/span><\/p>\n

\u4e00\u822c\u516c\u8ba4\u4f1a\u8ba1\u539f\u5219\u00a0(Generally Accepted Accounting Principles)<\/span><\/p>\n

GC<\/span><\/p>\n

=<\/span><\/p>\n

\u80c3\u764c\u00a0(Gastric cancer)<\/span><\/p>\n

HR<\/span><\/p>\n

=<\/span><\/p>\n

\u98ce\u9669\u6bd4\u00a0(Hazard Ratio)<\/span><\/p>\n

\u6d77\u5357\u5148\u884c\u533a<\/span><\/p>\n

=<\/span><\/p>\n

\u6d77\u5357\u535a\u9ccc\u4e50\u57ce\u56fd\u9645\u533b\u7597\u65c5\u6e38\u5148\u884c\u533a\u00a0(Hainan Boao Lecheng International Medical Tourism Pilot Zone)<\/span><\/p>\n

\u9999\u6e2f\u4ea4\u6613\u6240\u00a0(HKEX)<\/span><\/p>\n

=<\/span><\/p>\n

\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u00a0(The Main Board of The Stock Exchange of Hong Kong Limited)<\/span><\/p>\n

ICML<\/span><\/p>\n

=<\/span><\/p>\n

\u56fd\u9645\u6076\u6027\u6dcb\u5df4\u7624\u4f1a\u8bae\u00a0(International Conference on Malignant Lymphoma)<\/span><\/p>\n

IDH1\/2<\/span><\/p>\n

=<\/span><\/p>\n

\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\u6216\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-2 (Isocitrate dehydrogenase-1 OR isocitrate dehydrogenase-2)<\/span><\/p>\n

IHCC<\/span><\/p>\n

=<\/span><\/p>\n

\u809d\u5185\u80c6\u7ba1\u764c\u00a0(Intrahepatic cholangiocarcinoma)<\/span><\/p>\n

IIT<\/span><\/p>\n

=<\/span><\/p>\n

\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c (Investigator-initiated trial)<\/span><\/p>\n

IND<\/span><\/p>\n

=<\/span><\/p>\n

\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u00a0(Investigational new drug application)<\/span><\/p>\n

\u521b\u54cd\u751f\u7269\u00a0(Inmagene)<\/span><\/p>\n

=<\/span><\/p>\n

Inmagene Biopharmaceuticals<\/span><\/p>\n

\u5e02\u573a\u9500\u552e\u989d<\/span><\/p>\n

=<\/span><\/p>\n

\u7531\u793c\u6765\uff08\u7231\u4f18\u7279\u00ae\uff09\u3001\u6b66\u7530\uff08FRUZAQLA\u00ae\uff09\u3001\u963f\u65af\u5229\u5eb7\uff08\u6c83\u745e\u6c99\u00ae\uff09\u53ca\u548c\u9ec4\u533b\u836f\uff08\u7231\u4f18\u7279\u00ae\u3001\u82cf\u6cf0\u8fbe\u00ae\u3001\u6c83\u745e\u6c99\u00ae\u53ca\u8fbe\u552f\u73c2\u00ae\uff09\u5411\u7b2c\u4e09\u65b9\u7684\u603b\u9500\u552e\u989d\u3002<\/span><\/p>\n

Ipsen<\/span><\/p>\n

=<\/span><\/p>\n

Ipsen SA\uff0cEpizyme, Inc.\u7684\u6bcd\u516c\u53f8<\/span><\/p>\n

IRC<\/span><\/p>\n

=<\/span><\/p>\n

\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\u00a0(Independent review committee)<\/span><\/p>\n

ITP<\/span><\/p>\n

=<\/span><\/p>\n

\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u00a0(Immune thrombocytopenia purpura)<\/span><\/p>\n

ITT<\/span><\/p>\n

=<\/span><\/p>\n

\u610f\u5411\u6027\u6cbb\u7597\u00a0(Intend-to-treat)<\/span><\/p>\n

JAK<\/span><\/p>\n

=<\/span><\/p>\n

Janus\u6fc0\u9176\u00a0(Janus kinase)<\/span><\/p>\n

JAMA<\/span><\/p>\n

=<\/span><\/p>\n

\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b(Journal of the American Medical Association)<\/span><\/p>\n

LPR<\/span><\/p>\n

=<\/span><\/p>\n

\u8d37\u6b3e\u5e02\u573a\u62a5\u4ef7\u5229\u7387\u00a0(Loan Prime Rate)<\/span><\/p>\n

MAPK<\/span><\/p>\n

=<\/span><\/p>\n

\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\u00a0(Mitogen-activated protein kinase)<\/span><\/p>\n

mDoR<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u00a0(median Duration of response)<\/span><\/p>\n

MET<\/span><\/p>\n

=<\/span><\/p>\n

\u95f4\u8d28\u4e0a\u76ae\u8f6c\u5316\u56e0\u5b50\u00a0(Mesenchymal epithelial transition factor)<\/span><\/p>\n

METex14<\/span><\/p>\n

=<\/span><\/p>\n

MET\u5916\u663e\u5b5014\u8df3\u53d8\u00a0(MET exon 14 skipping alteration)<\/span><\/p>\n

MLL<\/span><\/p>\n

=<\/span><\/p>\n

\u6df7\u5408\u8c31\u7cfb\u767d\u8840\u75c5\u00a0(Mixed-lineage leukemia)<\/span><\/p>\n

mOS<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u00a0(median Overall survival)<\/span><\/p>\n

mPFS<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u00a0(median Progression-free survival)<\/span><\/p>\n

MSS<\/span><\/p>\n

=<\/span><\/p>\n

\u5fae\u536b\u661f\u7a33\u5b9a\u00a0(Microsatellite stable)<\/span><\/p>\n

NDA<\/span><\/p>\n

=<\/span><\/p>\n

\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u00a0(New Drug Application)<\/span><\/p>\n

NET<\/span><\/p>\n

=<\/span><\/p>\n

\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u00a0(Neuroendocrine tumor)<\/span><\/p>\n

NHL<\/span><\/p>\n

=<\/span><\/p>\n

\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u00a0(Non-Hodgkin lymphoma)<\/span><\/p>\n

NHS<\/span><\/p>\n

=<\/span><\/p>\n

\u82f1\u56fd\u56fd\u5bb6\u533b\u7597\u670d\u52a1\u4f53\u7cfb\u00a0(National Health Service in the United Kingdom))<\/span><\/p>\n

NHSA<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u56fd\u56fd\u5bb6\u533b\u7597\u4fdd\u969c\u5c40\u00a0(China National Healthcare Security Administration)<\/span><\/p>\n

\u56fd\u5bb6\u836f\u76d1\u5c40\u00a0(NMPA)<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u00a0(China National Medical Products Administration)<\/span><\/p>\n

NPM1<\/span><\/p>\n

=<\/span><\/p>\n

\u6838\u78f7\u86cb\u767d1 (Nucleophosmin 1)<\/span><\/p>\n

\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u00a0(NRDL)<\/span><\/p>\n

=<\/span><\/p>\n

\u300a\u4e2d\u56fd\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u300b(China National Reimbursement Drug List)<\/span><\/p>\n

NSCLC<\/span><\/p>\n

=<\/span><\/p>\n

\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u00a0(Non-small cell lung cancer)<\/span><\/p>\n

ORR<\/span><\/p>\n

=<\/span><\/p>\n

\u5ba2\u89c2\u7f13\u89e3\u7387\u00a0(Objective response rate)<\/span><\/p>\n

OS<\/span><\/p>\n

=<\/span><\/p>\n

\u603b\u751f\u5b58\u671f\u00a0(Overall survival)<\/span><\/p>\n

\u4eba\u6c11\u94f6\u884c\u00a0(PBOC)<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u56fd\u4eba\u6c11\u94f6\u884c\u00a0(People’s Bank of China)<\/span><\/p>\n

PD-1<\/span><\/p>\n

=<\/span><\/p>\n

\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1 (Programmed cell death protein-1)<\/span><\/p>\n

PDAC<\/span><\/p>\n

=<\/span><\/p>\n

\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u00a0(Pancreatic ductal adenocarcinoma)<\/span><\/p>\n

PFS<\/span><\/p>\n

=<\/span><\/p>\n

\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u00a0(Progression free survival)<\/span><\/p>\n

PI3K<\/span><\/p>\n

=<\/span><\/p>\n

\u78f7\u9178\u808c\u9187-3-\u6fc0\u9176 (Phosphatidylinositol 3-kinase)<\/span><\/p>\n

PI3K\u03b4<\/span><\/p>\n

=<\/span><\/p>\n

\u78f7\u9178\u808c\u9187-3-\u6fc0\u9176\u03b4\u00a0(Phosphoinositide 3-kinase-\u03b4)<\/span><\/p>\n

pMMR<\/span><\/p>\n

=<\/span><\/p>\n

\u9519\u914d\u4fee\u590d\u5b8c\u6574\u00a0(Proficient mismatch repair)<\/span><\/p>\n

pNET<\/span><\/p>\n

=<\/span><\/p>\n

\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u00a0(Pancreatic neuroendocrine tumor)<\/span><\/p>\n

PRCC<\/span><\/p>\n

=<\/span><\/p>\n

\u4e73\u5934\u72b6\u80be\u7ec6\u80de\u764c\u00a0(Papillary renal cell carcinoma)<\/span><\/p>\n

PTCL<\/span><\/p>\n

=<\/span><\/p>\n

\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\u00a0(Peripheral T-cell lymphomas)<\/span><\/p>\n

R\/R<\/span><\/p>\n

=<\/span><\/p>\n

\u590d\u53d1\u53ca\/\u6216\u96be\u6cbb\u6027\u00a0(Relapsed and\/or refractory)<\/span><\/p>\n

RAS<\/span><\/p>\n

=<\/span><\/p>\n

\u5927\u9f20\u8089\u7624\u00a0(Rat sarcoma)<\/span><\/p>\n

RCC<\/span><\/p>\n

=<\/span><\/p>\n

\u80be\u7ec6\u80de\u764c\u00a0(Renal cell carcinoma)<\/span><\/p>\n

\u4eba\u6c11\u5e01\u00a0(RMB)<\/span><\/p>\n

=<\/span><\/p>\n

\u4e2d\u56fd\u6cd5\u5b9a\u8d27\u5e01\u00a0<\/span><\/p>\n

RP2D<\/span><\/p>\n

=<\/span><\/p>\n

II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u5242\u91cf\u00a0(The recommended phase 2 dose)<\/span><\/p>\n

RP3D<\/span><\/p>\n

=<\/span><\/p>\n

III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u5242\u91cf\u00a0(The recommended phase 3 dose)<\/span><\/p>\n

\u9500\u552e\u53ca\u884c\u653f\u5f00\u652f\u00a0(S&A)<\/span><\/p>\n

=<\/span><\/p>\n

\u9500\u552e\u53ca\u884c\u653f\u5f00\u652f\u00a0(Selling and administrative expenses)<\/span><\/p>\n

SHP2<\/span><\/p>\n

=<\/span><\/p>\n

\u9776\u5411Src\u540c\u6e902\u7ed3\u6784\u57df\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176\u00a0(SH2 containing protein tyrosine phosphatase-2)<\/span><\/p>\n

\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u00a0(SHPL)<\/span><\/p>\n

=<\/span><\/p>\n

\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u6709\u9650\u516c\u53f8\u00a0(Shanghai Hutchison Pharmaceuticals Limited)<\/span><\/p>\n

SLL<\/span><\/p>\n

=<\/span><\/p>\n

\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u00a0(Small lymphocytic lymphoma)<\/span><\/p>\n

sNDA<\/span><\/p>\n

=<\/span><\/p>\n

\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u00a0(supplemental New Drug Application)<\/span><\/p>\n

STAT<\/span><\/p>\n

=<\/span><\/p>\n

\u4fe1\u53f7\u8f6c\u6362\u5668\u548c\u8f6c\u5f55\u6fc0\u6d3b\u5668\u00a0(Signal transducer and activator of transcription)<\/span><\/p>\n

Syk<\/span><\/p>\n

=<\/span><\/p>\n

\u813e\u916a\u6c28\u9178\u6fc0\u9176\u00a0(Spleen tyrosine kinase)<\/span><\/p>\n

\u6b66\u7530\u00a0(Takeda)<\/span><\/p>\n

=<\/span><\/p>\n

Takeda Pharmaceuticals International AG, Takeda Pharmaceutical Company Limited \u7684\u9644\u5c5e\u516c\u53f8<\/span><\/p>\n

TEAE<\/span><\/p>\n

=<\/span><\/p>\n

\u6cbb\u7597\u671f\u95f4\u4e0d\u826f\u4e8b\u4ef6\u00a0(Treatment emergent adverse events)<\/span><\/p>\n

TKI<\/span><\/p>\n

=<\/span><\/p>\n

\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u00a0(Tyrosine kinase inhibitor)<\/span><\/p>\n

TPO<\/span><\/p>\n

=<\/span><\/p>\n

\u8840\u5c0f\u677f\u751f\u6210\u7d20\u00a0(Thrombopoietin)<\/span><\/p>\n

TPO-RA<\/span><\/p>\n

=<\/span><\/p>\n

\u8840\u5c0f\u677f\u751f\u6210\u7d20\u53d7\u4f53\u6fc0\u52a8\u5242\u00a0(Thrombopoietin receptor agonists)<\/span><\/p>\n

TRAE<\/span><\/p>\n

=<\/span><\/p>\n

\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u00a0(Treatment-related adverse events)<\/span><\/p>\n

VEGFR<\/span><\/p>\n

=<\/span><\/p>\n

\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u00a0(Vascular endothelial growth factor receptor)<\/span><\/p>\n

wAIHA<\/span><\/p>\n

=<\/span><\/p>\n

\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u00a0(Warm autoimmune haemolytic anaemia)<\/span><\/p>\n

WCLC<\/span><\/p>\n

=<\/span><\/p>\n

\u4e16\u754c\u80ba\u764c\u5927\u4f1a\u00a0(World Conference on Lung Cancer)<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

SOURCE \u548c\u9ec4\u533b\u836f(\u4e2d\u56fd)\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"

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%\u0394 (\u56fa\u5b9a\u6c47\u7387) 2025\u5e74\u4e0a\u534a\u5e74 2024\u5e74\u4e0a\u534a\u5e74 %\u0394 (\u56fa\u5b9a\u6c47\u7387) FRUZAQLA\u00ae $162.8 $130.5 +25\u00a0% (+25\u00a0%) $43.1 $42.8 +1\u00a0% (+1\u00a0%) \u7231\u4f18\u7279\u00ae $43.0 $61.0 […]<\/p>\n","protected":false},"author":0,"featured_media":14518,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-14517","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u548c\u9ec4\u533b\u836f\u516c\u5e032025\u5e74\u4e2d\u671f\u4e1a\u7ee9 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u516c\u5e032025\u5e74\u4e2d\u671f\u4e1a\u7ee9\/\" \/>\n<meta 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