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\u5173\u4e8e\u7f8e\u56fd\u5904\u65b9\u4fe1\u606f\uff1a \u5173\u4e8e\u6b27\u76df\u4ea7\u54c1\u7279\u6027\u6458\u8981\uff1a \u5173\u4e8e\u548c\u9ec4\u533b\u836f \u524d\u77bb\u6027\u9648\u8ff0 \u533b\u7597\u4fe1\u606f \u5185\u5e55\u6d88\u606f [1]\u00a0\u00a0 Foundation for Promotion of Cancer Research. Cancer Statistics In Japan. Tokyo, Foundation for Promotion of Cancer Research; 2023.<\/span><\/p>\n [2]\u00a0\u00a0 Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin. 2024;74(3):229-263. doi:10.3322\/caac.21834.<\/span><\/p>\n [3]\u00a0\u00a0 Ferlay J, et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https:\/\/gco.iarc.who.int\/today, accessed 12 June 2024.<\/span><\/p>\n [4]\u00a0\u00a0 American Cancer Society. Cancer Facts & Figures 2024. Atlanta, American Cancer Society; 2024.<\/span><\/p>\n [5]\u00a0\u00a0 Bando H, et al. Therapeutic landscape and future direction of metastatic colorectal cancer. Nat Rev Gastroenterol Hepatol\u00a02023; 20(5)306\u2011322. doi:10.1038\/s41575\u2011022\u201100736\u20111.<\/span><\/p>\n [6]\u00a0\u00a0 D’Haene N, et al. Clinical application of targeted next\u2011generation sequencing for colorectal cancer patients: a multicentric Belgian experience. Oncotarget. 2018;9(29):20761\u201120768. Published 2018 Apr 17. doi:10.18632\/oncotarget.25099.<\/span><\/p>\n [7]\u00a0\u00a0 Venderbosch S, et al. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: A pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies. Clinical Cancer Res. 2014; 20(20):5322\u20135330. doi:10.1158\/1078\u20110432.ccr\u201114\u20110332.<\/span><\/p>\n [8]\u00a0\u00a0 Koopman M, et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer. 2009;100(2), 266\u2013273. doi:10.1038\/sj.bjc.6604867.<\/span><\/p>\n [9]\u00a0\u00a0 Ahcene Djaballah S, et al. HER2 in Colorectal Cancer: The Long and Winding Road From Negative Predictive Factor to Positive Actionable Target. Am Soc Clin Oncol Educ Book. 2022;42:1\u201114. doi:10.1200\/EDBK_351354.<\/span><\/p>\n [10]\u00a0 Dasari NA, et al. LBA25 \u2013 FRESCO\u20112: A global Phase III multiregional clinical trial (MRCT) evaluating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer. Ann Oncol.\u00a02022 Sep;33(suppl_7): S808\u2011S869. doi:10.1016\/annonc\/annonc1089.<\/span><\/p>\n [11]\u00a0 Dasari NA, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO\u20112): an international, multicentre, randomised, double\u2011blind, Phase III study. 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https:\/\/www.fruzaqla.com\/sites\/default\/files\/resources\/fruzaqla-prescribing-information.pdf<\/a><\/p>\n
https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/fruzaqla<\/a><\/p>\n
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