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\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2025\u5e749\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5ba3\u5e03\uff1a\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff08XOI\uff09\u66ff\u53e4\u7d22\u53f8\u4ed6\u7247\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI128\uff09\u5728\u4e2d\u56fd\u75db\u98ce\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7ed3\u679c\u57282025\u5e74\u4e9a\u592a\u98ce\u6e7f\u75c5\u534f\u4f1a\u8054\u76df\u5927\u4f1a\uff08APLAR\uff09\u53d1\u8868\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u66ff\u53e4\u7d22\u53f8\u4ed6\u5404\u5242\u91cf\u7ec4\u76f8\u8f83\u975e\u5e03\u53f8\u4ed6\u7ec4\u5747\u5c55\u73b0\u51fa\u4e86\u66f4\u663e\u8457\u7684\u964d\u5c3f\u9178\u6548\u679c\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u57fa\u4e8e\u8be5\u79ef\u6781\u7ed3\u679c\uff0c\u4fe1\u8fbe\u751f\u7269\u8ba1\u5212\u4e8e2025\u5e74\u4e0b\u534a\u5e74\u542f\u52a8\u66ff\u53e4\u7d22\u53f8\u4ed6\u7247\uff08IBI128\uff09\u4e2d\u56fd\u6ce8\u518c\u4e34\u5e8aIII\u671f\u7814\u7a76\u3002<\/p>\n

\u6b64\u6b21\u53d1\u8868\u7684\u7ed3\u679c\u662f\u57fa\u4e8e\u4e00\u9879\u63a2\u7d22\u4e0d\u540c\u5242\u91cf\u66ff\u53e4\u7d22\u53f8\u4ed6\u7247\uff08IBI128\uff09\u5728\u4e2d\u56fd\u75db\u98ce\u60a3\u8005\u4e2d\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u3001\u5e73\u884c\u3001\u6d3b\u6027\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT06501534\uff09\u3002\u7814\u7a76\u5165\u7ec484\u4f8b\u75db\u98ce\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f8437\u5c81\uff0c\u5e73\u5747\u57fa\u7ebf\u8840\u5c3f\u9178575 \u03bcmol\/L [9.6 mg\/dL]\uff0c\u5e73\u5747\u57fa\u7ebf\u4f53\u91cd80.7 kg\uff09\uff0c\u968f\u673a\u63a5\u53d7\u66ff\u53e4\u7d22\u53f8\u4ed6\u724750 mg\u3001100 mg\u3001200 mg\u6216\u975e\u5e03\u53f8\u4ed6\u724740 mg\u6cbb\u7597\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u7b2c16\u5468\u5404\u6cbb\u7597\u7ec4\u53c2\u4e0e\u8005\u7684\u8840\u5c3f\u9178\u8fbe\u5230<360\u03bcmol\/L\uff086 mg\/dL\uff09\u7684\u6bd4\u4f8b\u3002<\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u66ff\u53e4\u7d22\u53f8\u4ed6\u5404\u5242\u91cf\u7ec4\u76f8\u8f83\u975e\u5e03\u53f8\u4ed6\u7ec4\u5747\u5c55\u73b0\u51fa\u4e86\u66f4\u5927\u5e45\u5ea6\u4e14\u663e\u8457\u7684\u964d\u5c3f\u9178\u6548\u679c\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\uff1b\u4e0d\u540c\u6cbb\u7597\u7ec4\u95f4\u7597\u6548\u4e5f\u5b58\u5728\u826f\u597d\u7684\u5242\u91cf\u76f8\u5173\u6027\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

* P\uff1c0.05,** P\uff1c0.01, *** P\uff1c0.001\u3002<\/p>\n

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\u5173\u4e8e\u75db\u98ce<\/p>\n

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\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/p>\n

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\u524d\u77bb\u6027\u58f0\u660e<\/p>\n

\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528”\u9884\u671f”\u3001”\u76f8\u4fe1”\u3001”\u9884\u6d4b”\u3001”\u671f\u671b”\u3001”\u6253\u7b97”\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n

\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n

\u53c2\u8003\u6587\u732e
[1].\u00a0\u00a0\u00a0 Lisa K Stamp et al., (2021). Association between serum urate and flares in peoplewith gout and evidence for surrogate status: a secondary analysis of tworandomised controlled trials. The Lancet Rheumatology. DOI: https:\/\/doi.org\/10.1016\/S2665-9913<\/a>(21)00319-2
[2].\u00a0\u00a0\u00a0 Martillo MA, Nazzal L, Crittenden DB. (2014). The crystallization of monosodium urate. Current Rheumatol Rep.16(2):400.
[3].\u00a0\u00a0\u00a0 \u4e2d\u534e\u533b\u5b66\u4f1a\u5185\u5206\u6ccc\u5b66\u5206\u4f1a. 2019\u5e74\u4e2d\u56fd\u9ad8\u5c3f\u9178\u8840\u75c7\u4e0e\u75db\u98ce\u8bca\u7597\u6307\u5357. \u4e2d\u534e\u5185\u5206\u6ccc\u4ee3\u8c22\u6742\u5fd7, 2020,36(01) : 1-13.
[4].\u00a0\u00a0\u00a0 Hyndman D, Liu S, Miner JN. (2016). Urate handling in the human body. Curr Rheumatol Rep. 18(6):34.
[5].\u00a0\u00a0\u00a0 Sattui SE, Gaffo AL. (2016). Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 8(4):145-159.
[6].\u00a0\u00a0\u00a0 White WB, Saag KG, Becker MA, et al. (2018). Cardiovascular safety of febuxostat or allopurinol in patients with gout. N Engl J Med 378:1200-1210.
[7].\u00a0\u00a0\u00a0\u00a0 Prescribing Information ULORIC (febuxostat) tablet for oral use https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/021856s013lbl.pdf<\/a> Accessed 2 Jun 2019<\/span>.<\/p>\n

\n<\/div>\n

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[…]<\/p>\n","protected":false},"author":0,"featured_media":15452,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-15451","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03IBI128\uff08\u66ff\u53e4\u7d22\u53f8\u4ed6\u7247\uff0cXOI\uff09\u75db\u98ce\u4e34\u5e8aII\u671f\u7814\u7a76\u7ed3\u679c\u4e8e\u4e9a\u592a\u98ce\u6e7f\u75c5\u534f\u4f1a\u8054\u76df\u5927\u4f1a\uff08APLAR\uff09\u516c\u5e03 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03ibi128\uff08\u66ff\u53e4\u7d22\u53f8\u4ed6\u7247\uff0cxoi\uff09\u75db\u98ce\u4e34\u5e8aii\u671f\u7814\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03IBI128\uff08\u66ff\u53e4\u7d22\u53f8\u4ed6\u7247\uff0cXOI\uff09\u75db\u98ce\u4e34\u5e8aII\u671f\u7814\u7a76\u7ed3\u679c\u4e8e\u4e9a\u592a\u98ce\u6e7f\u75c5\u534f\u4f1a\u8054\u76df\u5927\u4f1a\uff08APLAR\uff09\u516c\u5e03 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2025\u5e749\u67088\u65e5 \/\u7f8e\u901a\u793e\/ — 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