{"id":15785,"date":"2025-09-15T00:00:00","date_gmt":"2025-09-15T00:00:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e6%85%a2%e6%80%a7%e4%b9%99%e8%82%9d%e9%80%82%e5%ba%94%e7%97%87%e8%8e%b7%e6%89%b9ind%ef%bc%8c%e6%9d%a5%e6%81%a9%e7%94%9f%e7%89%a9tcr-t%e7%96%97%e6%b3%95%e4%b8%89%e8%8e%b7fda%e8%ae%a4%e5%8f%af\/"},"modified":"2025-09-15T00:00:00","modified_gmt":"2025-09-15T00:00:00","slug":"%e6%85%a2%e6%80%a7%e4%b9%99%e8%82%9d%e9%80%82%e5%ba%94%e7%97%87%e8%8e%b7%e6%89%b9ind%ef%bc%8c%e6%9d%a5%e6%81%a9%e7%94%9f%e7%89%a9tcr-t%e7%96%97%e6%b3%95%e4%b8%89%e8%8e%b7fda%e8%ae%a4%e5%8f%af","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e6%85%a2%e6%80%a7%e4%b9%99%e8%82%9d%e9%80%82%e5%ba%94%e7%97%87%e8%8e%b7%e6%89%b9ind%ef%bc%8c%e6%9d%a5%e6%81%a9%e7%94%9f%e7%89%a9tcr-t%e7%96%97%e6%b3%95%e4%b8%89%e8%8e%b7fda%e8%ae%a4%e5%8f%af\/","title":{"rendered":"\u6162\u6027\u4e59\u809d\u9002\u5e94\u75c7\u83b7\u6279IND\uff0c\u6765\u6069\u751f\u7269TCR-T\u7597\u6cd5\u4e09\u83b7FDA\u8ba4\u53ef"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u65b0\u52a0\u5761\u548c\u5e7f\u5dde<\/span><span class=\"legendSpanClass\">2025\u5e749\u670815\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u6765\u6069\u751f\u7269\uff08Lion TCR\uff09\u5ba3\u5e03\u5176\u521b\u65b0mRNA\u7f16\u7801TCR-T\u7ec6\u80de\u7597\u6cd5\u4ea7\u54c1LioCyx-M004\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\uff0c\u5f00\u5c55\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\uff08CHB\uff09\u76841b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u3002\u8fd9\u662f\u5168\u7403\u9996\u4e2a\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u6162\u6027\u4e59\u578b\u809d\u708e\u6cbb\u7597\u7684TCR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u540c\u65f6\u4e5f\u662f\u9996\u4e2a\u83b7\u5f97FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684\u4e59\u809d\u75c5\u6bd2\u7279\u5f02\u6027TCR-T\u7597\u6cd5\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/2617765\/Lion_TCR_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>01 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\u5168\u7403\u4e59\u809d\u8d1f\u62c5\uff1a\u8fd13\u4ebf\u60a3\u8005\u4e9f\u9700\u6cbb\u6108\uff0c\u521b\u65b0\u7597\u6cd5\u5e26\u6765\u65b0\u5e0c\u671b<\/p>\n<p>\u4e59\u809d\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u5168\u7403\u5065\u5eb7\u7684\u91cd\u5927\u6311\u6218\uff0c\u5168\u7403\u6162\u6027\u4e59\u809d\u60a3\u8005\u7ea62.96\u4ebf\uff0c\u5176\u4e2d\u4e2d\u56fd\u60a3\u8005\u8d85\u8fc78600\u4e07\uff0c\u6cbb\u7597\u9700\u6c42\u6781\u4e3a\u8feb\u5207\u3002\u5f53\u524d\u6297\u75c5\u6bd2\u836f\u7269\u96be\u4ee5\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\uff08\u5373\u4e59\u809d\u8868\u9762\u6297\u539f\u6301\u7eed\u6e05\u9664\uff09\uff0c\u4ec5\u4e0d\u523010%\u7684\u60a3\u8005\u75c5\u60c5\u5f97\u5230\u6709\u6548\u63a7\u5236\u3002\u6765\u6069\u751f\u7269\u7814\u53d1\u7684TCR-T\u7597\u6cd5LioCyx-M004\u901a\u8fc7\u7cbe\u51c6\u9776\u5411HBV\u611f\u67d3\u7ec6\u80de\u3001\u6fc0\u6d3b\u75c5\u6bd2\u7279\u5f02\u6027T\u7ec6\u80de\u514d\u75ab\uff0c\u4e3a\u5168\u7403\u6570\u4ebf\u60a3\u8005\u5e26\u6765\u4e86\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\u7684\u65b0\u5e0c\u671b\u3002<\/p>\n<p>03 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\u6211\u4eec\u6b63\u901a\u8fc7\u5242\u91cf\u722c\u5761\u7814\u7a76\u5bfb\u627e\u6700\u4f73\u6cbb\u7597\u5242\u91cf\u548c\u65b9\u6848\u3002&#8221;<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u60a3\u8005\u5728\u6cbb\u7597\u524d\u4e0d\u9700\u8981\u6e05\u6dcb\uff08\u6e05\u9664\u6dcb\u5df4\u7ec6\u80de\uff09\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u60a3\u8005\u7528\u836f\u5b89\u5168\u6027\u548c\u53ef\u53ca\u6027\u3002\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u672a\u89c2\u5bdf\u5230\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u6216\u795e\u7ecf\u6bd2\u6027\u53cd\u5e94\uff0c\u8bf4\u660emRNA\u7f16\u7801TCR-T\u7597\u6cd5\u662f\u4e00\u79cd\u5b89\u5168\u6709\u6548\u7684\u7597\u6cd5\u3002<\/p>\n<p>04 \u6218\u7565\u5347\u7ea7\uff1a\u4ece\u80bf\u7624\u6cbb\u7597\u8fc8\u5411\u6297\u75c5\u6bd2\u65b0\u6218\u573a<\/p>\n<p>\u6765\u6069\u751f\u7269\u9996\u5e2d\u6267\u884c\u5b98\u5f6d\u6653\u660e\u535a\u58eb\u5c06\u6b64\u6b21\u83b7\u6279\u89c6\u4e3a\u516c\u53f8\u53d1\u5c55\u7684\u5173\u952e\u8f6c\u6298\u70b9\uff1a&#8221;\u6b64\u6b21\u83b7\u6279\u5f00\u5c55\u6162\u6027\u4e59\u578b\u809d\u708e\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6807\u5fd7\u7740\u6211\u4eec\u7684\u5e73\u53f0\u6280\u672f\u5b9e\u73b0\u4e86\u4ece\u80bf\u7624\u6cbb\u7597\u9886\u57df\u5411\u75c5\u6bd2\u611f\u67d3\u6cbb\u7597\u9886\u57df\u7684\u6218\u7565\u6027\u62d3\u5c55\u3002\u968f\u7740\u4e34\u5e8a\u8bd5\u9a8c\u7684\u63a8\u8fdb\uff0c\u6211\u4eec\u5c06\u52a0\u901f\u5b8c\u6210\u4ece\u5b9e\u9a8c\u5ba4\u5230\u4e34\u5e8a\u3001\u518d\u4ece\u4e34\u5e8a\u5230\u5e02\u573a\u7684\u5b8c\u6574\u4ef7\u503c\u94fe\u6784\u5efa\uff0c\u4e3a\u5168\u7403\u6570\u4ebf\u4e59\u809d\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u7684\u540c\u65f6\uff0c\u5b9e\u73b0\u4f01\u4e1a\u7684\u5546\u4e1a\u4ef7\u503c\u548c\u793e\u4f1a\u4ef7\u503c\u7684\u53cc\u91cd\u56de\u62a5\u3002&#8221;<\/p>\n<p>05 \u672a\u6765\u5e03\u5c40\uff1ain vivo TCR-T\u7597\u6cd5\u83b7\u6743\u5a01\u9a8c\u8bc1\uff0c\u4ea7\u4e1a\u8f6c\u5316\u8fdb\u7a0b\u52a0\u901f<\/p>\n<p>\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u6765\u6069\u751f\u7269\u7684mRNA\u7f16\u7801\u9776\u5411HBV\u7684in vivo TCR-T\u5df2\u88ab\u7f8e\u56fd\u8457\u540d\u80bf\u7624\u7814\u7a76\u6240\u9a8c\u8bc1\u3002\u7814\u7a76\u8868\u660e\uff0c\u8be5\u7597\u6cd5\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u663e\u8457\u7684\u6740\u4f24HBV\u9633\u6027\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u5176\u6cbb\u7597\u6548\u679c\u4e0e\u4f53\u5916\u5de5\u7a0b\u5316\u6539\u9020\u7684T\u7ec6\u80de\u76f8\u5f53\uff0c\u8fd9\u4e3a\u9776\u5411HBV\u7684in vivo TCR-T\u4ea7\u4e1a\u8f6c\u5316\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u79d1\u5b66\u57fa\u7840\u3002<\/p>\n<p>\u76ee\u524d\u516c\u53f8\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u8fd9\u4e00\u521b\u65b0\u65b9\u5411\uff0c\u52a0\u5febin vivo TCR-T\u7597\u6cd5\u7684\u5f00\u53d1\u8fdb\u7a0b\u3002\u4e0e\u4f20\u7edf\u4f53\u5916\u6539\u9020T\u7ec6\u80de\u7597\u6cd5\u76f8\u6bd4\uff0cin vivo TCR-T\u7597\u6cd5\u5177\u6709\u73b0\u8d27\u578b\u3001\u6210\u672c\u4f4e\u3001\u53ef\u53ca\u6027\u9ad8\u7b49\u4f18\u52bf\uff0c\u6709\u671b\u4e3a\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597\u673a\u4f1a\u3002<\/p>\n<p>\u516c\u53f8\u8fd8\u5728\u5347\u7ea7AI\u8d4b\u80fd\u7684TCR\u9776\u70b9\u53d1\u73b0\u5e73\u53f0\uff0c\u8ba1\u5212\u5c06\u4ea7\u54c1\u7ba1\u7ebf\u62d3\u5c55\u81f3\u80ba\u764c\u3001\u4e73\u817a\u764c\u548c\u6d88\u5316\u9053\u80bf\u7624\u7b49\u66f4\u591a\u5b9e\u4f53\u7624\u9886\u57df\u3002<\/p>\n<p><span>###<\/span><\/p>\n<p>\u5173\u4e8e\u6765\u6069\u751f\u7269\u00a0<\/p>\n<p>\u6765\u6069\u751f\u7269\u662f\u4e00\u5bb6\u4ece\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u6280\u672f\u516c\u53f8\u3002\u5176\u6838\u5fc3\u4ea7\u54c1\u6cbb\u7597\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u76f8\u5173\u6027\u75be\u75c5\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u5f00\u5c55\u56fd\u9645\u591a\u4e2d\u5fc3\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u3001\u9776\u5411HBV\u7684TCR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u5e76\u5df2\u83b7\u5f97FDA\u5feb\u901f\u901a\u9053\u548c\u5b64\u513f\u836f\u8d44\u8d28\uff0c\u540c\u65f6\u4e5f\u5df2\u53d6\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9ed8\u793a\u8bb8\u53ef\u3002<\/p>\n<p>\u516c\u53f8\u4f9d\u6258AI\u9a71\u52a8\u7684TCR\u53d1\u73b0\u5e73\u53f0\u548cRNA\u6280\u672f\uff0c\u6b63\u79ef\u6781\u5c06\u4ea7\u54c1\u7ba1\u7ebf\u62d3\u5c55\u81f3\u591a\u79cd\u5b9e\u4f53\u7624\u53ca\u611f\u67d3\u6027\u75be\u75c5\u9886\u57df\u3002\u6765\u6069\u751f\u7269\u5e03\u5c40\u4e86\u5305\u62ec\u81ea\u4f53\u7ec6\u80de\u6cbb\u7597\u548c\u901a\u7528\u578b\u7597\u6cd5\u5728\u5185\u7684\u591a\u5143\u4ea7\u54c1\u4f53\u7cfb\uff0c\u5e76\u81f4\u529b\u4e8e\u5f00\u53d1in vivo TCR-T\u7597\u6cd5\uff0c\u663e\u8457\u964d\u4f4e\u6cbb\u7597\u6210\u672c\uff0c\u63d0\u5347\u53ef\u53ca\u6027\u3002<\/p>\n<p>SOURCE  Lion TCR<\/p>","protected":false},"excerpt":{"rendered":"<p>\u65b0\u52a0\u5761\u548c\u5e7f\u5dde2025\u5e749\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u6765\u6069\u751f\u7269\uff08Lion 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05 \u672a\u6765\u5e03\u5c40\uff1ain vivo TCR-T\u7597\u6cd5\u83b7\u6743\u5a01\u9a8c\u8bc1\uff0c\u4ea7\u4e1a\u8f6c\u5316\u8fdb\u7a0b\u52a0\u901f \u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u6765\u6069\u751f\u7269\u7684mRNA\u7f16\u7801\u9776\u5411HBV\u7684in vivo TCR-T\u5df2\u88ab\u7f8e\u56fd\u8457\u540d\u80bf\u7624\u7814\u7a76\u6240\u9a8c\u8bc1\u3002\u7814\u7a76\u8868\u660e\uff0c\u8be5\u7597\u6cd5\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u663e\u8457\u7684\u6740\u4f24HBV\u9633\u6027\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u5176\u6cbb\u7597\u6548\u679c\u4e0e\u4f53\u5916\u5de5\u7a0b\u5316\u6539\u9020\u7684T\u7ec6\u80de\u76f8\u5f53\uff0c\u8fd9\u4e3a\u9776\u5411HBV\u7684in vivo TCR-T\u4ea7\u4e1a\u8f6c\u5316\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u79d1\u5b66\u57fa\u7840\u3002 \u76ee\u524d\u516c\u53f8\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u8fd9\u4e00\u521b\u65b0\u65b9\u5411\uff0c\u52a0\u5febin vivo TCR-T\u7597\u6cd5\u7684\u5f00\u53d1\u8fdb\u7a0b\u3002\u4e0e\u4f20\u7edf\u4f53\u5916\u6539\u9020T\u7ec6\u80de\u7597\u6cd5\u76f8\u6bd4\uff0cin vivo TCR-T\u7597\u6cd5\u5177\u6709\u73b0\u8d27\u578b\u3001\u6210\u672c\u4f4e\u3001\u53ef\u53ca\u6027\u9ad8\u7b49\u4f18\u52bf\uff0c\u6709\u671b\u4e3a\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597\u673a\u4f1a\u3002 \u516c\u53f8\u8fd8\u5728\u5347\u7ea7AI\u8d4b\u80fd\u7684TCR\u9776\u70b9\u53d1\u73b0\u5e73\u53f0\uff0c\u8ba1\u5212\u5c06\u4ea7\u54c1\u7ba1\u7ebf\u62d3\u5c55\u81f3\u80ba\u764c\u3001\u4e73\u817a\u764c\u548c\u6d88\u5316\u9053\u80bf\u7624\u7b49\u66f4\u591a\u5b9e\u4f53\u7624\u9886\u57df\u3002 ### \u5173\u4e8e\u6765\u6069\u751f\u7269\u00a0 \u6765\u6069\u751f\u7269\u662f\u4e00\u5bb6\u4ece\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u6280\u672f\u516c\u53f8\u3002\u5176\u6838\u5fc3\u4ea7\u54c1\u6cbb\u7597\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u76f8\u5173\u6027\u75be\u75c5\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u5f00\u5c55\u56fd\u9645\u591a\u4e2d\u5fc3\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u3001\u9776\u5411HBV\u7684TCR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u5e76\u5df2\u83b7\u5f97FDA\u5feb\u901f\u901a\u9053\u548c\u5b64\u513f\u836f\u8d44\u8d28\uff0c\u540c\u65f6\u4e5f\u5df2\u53d6\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9ed8\u793a\u8bb8\u53ef\u3002 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