{"id":1782,"date":"2024-09-29T03:34:00","date_gmt":"2024-09-29T03:34:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e7%a7%91%e4%bc%a6%e5%8d%9a%e6%b3%b0trop2-adc%e8%8a%a6%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97%ef%bc%88sac-tmt%ef%bc%89%e5%a4%9a%e9%a1%b9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e6%88%90\/"},"modified":"2024-09-29T03:34:00","modified_gmt":"2024-09-29T03:34:00","slug":"%e7%a7%91%e4%bc%a6%e5%8d%9a%e6%b3%b0trop2-adc%e8%8a%a6%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97%ef%bc%88sac-tmt%ef%bc%89%e5%a4%9a%e9%a1%b9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e6%88%90","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e7%a7%91%e4%bc%a6%e5%8d%9a%e6%b3%b0trop2-adc%e8%8a%a6%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97%ef%bc%88sac-tmt%ef%bc%89%e5%a4%9a%e9%a1%b9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e6%88%90\/","title":{"rendered":"\u79d1\u4f26\u535a\u6cf0TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u4eae\u76f8CSCO"},"content":{"rendered":"

\u6210\u90fd<\/span>2024\u5e749\u670829\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 9\u670825\u65e5\u81f329\u65e5\uff0c\u7b2c27\u5c4a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u5927\u4f1a\u66a82024\u5e74CSCO\u5b66\u672f\u5e74\u4f1a\u5728\u53a6\u95e8\u9686\u91cd\u53ec\u5f00\u3002\u6765\u81ea\u5168\u56fd\u80bf\u7624\u9886\u57df\u7684\u4e13\u5bb6\u5b66\u8005\u9f50\u805a\u4e00\u5802\uff0c\u5171\u540c\u63a2\u8ba8\u4e34\u5e8a\u5b9e\u8df5\u7684\u524d\u6cbf\u70ed\u70b9\u3002\u4e8e\u5927\u4f1a\u4e0a\uff0c\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0”\u79d1\u4f26\u535a\u6cf0”\uff0c6990.HK\uff09\u53d1\u8868\u4e86TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297(sac-TMT)\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53ca\u8fdb\u5c55\u3002<\/p>\n

TNBC<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

9\u670827\u65e5\u4e0b\u5348\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u7684\u5f90\u5175\u6cb3\u9662\u58eb\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u5c31\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u6cbb\u7597\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09OptiTROP-Breast01 III\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u4e86\u53e3\u5934\u62a5\u544a\u548c\u8bba\u6587\u8ba8\u8bba\u3002<\/p>\n

\u6839\u636e\u76f2\u6001\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08BICR\uff09\u7684\u8bc4\u4f30\u7ed3\u679c\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u7ec4\uff08130\u4f8b\uff09\u4e2d\u4f4dPFS\u4e3a6.7\u4e2a\u6708\uff0c\u5316\u7597\u7ec4\uff08133\u4f8b\uff09\u4e3a2.5\u4e2a\u6708\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u76f8\u6bd4\u5316\u7597\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e68%\uff08HR=0.32\uff0c95% CI\uff1a0.22\uff5e0.44\uff09\u3002\u4e0e\u5316\u7597\u7ec4\u76f8\u6bd4\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u7ec4\u5728\u5404\u4e9a\u7ec4\u4e2dPFS\u5747\u663e\u8457\u5ef6\u957f\uff0c\u4e0e\u603b\u4f53\u4eba\u7fa4\u83b7\u76ca\u4e00\u81f4\u3002\u5728TROP2\u9ad8\u8868\u8fbe\uff08H\u8bc4\u5206>200\uff09\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u66f4\u597d\u7684PFS\u83b7\u76ca\u8d8b\u52bf\uff0csac-TMT\u7ec4\u548c\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dPFS\u5206\u522b\u4e3a8.3\u548c2.3\u4e2a\u6708\uff08HR 0.29 \uff0c95% CI: 0.19, 0.46\uff09\u3002OS\u671f\u4e2d\u5206\u6790\u663e\u793a\uff0csac-TMT\u7ec4\u7684\u4e2d\u4f4dOS\u5c1a\u672a\u8fbe\u5230\uff0895% CI\uff1a11.2\uff0cNE\uff09\uff0c\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a9.4\u4e2a\u6708\uff0895% CI\uff1a8.5\uff0c11.7\uff09\uff1bHR\u4e3a0.53\uff0895% CI\uff1a0.36\uff0c0.78\uff09\uff08P=0.0005\uff09\uff0csac-TMT\u76f8\u6bd4\u5316\u7597\u53d1\u751f\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e47%\u3002\u4e0e\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u76f8\u6bd4\uff0csac-TMT\u6cbb\u7597\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684PFS\u548cOS\u5747\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\uff0c\u4e14\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u6709\u671b\u6210\u4e3a\u8fd9\u7c7b\u60a3\u8005\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n

\u5f90\u5175\u6cb3\u9662\u58eb\u8868\u793a\uff1a”\u4e73\u817a\u764c\u662f\u5168\u7403\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\uff0c\u5a01\u80c1\u7740\u5973\u6027\u7684\u751f\u547d\u5065\u5eb7\uff0c\u5176\u4e2d\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\u9884\u540e\u5dee\uff0c\u751f\u5b58\u671f\u77ed\u3002\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u672a\u6765\u7684\u6cbb\u7597\u53d1\u5c55\u65b9\u5411\u662f\u7cbe\u51c6\u5206\u5c42\u6cbb\u7597\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u52a9\u4e8e\u6ee1\u8db3\u60a3\u8005\u66f4\u591a\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u672a\u6765\u6216\u6709\u671b\u6210\u4e3a\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u3002\u5bf9\u4e8eADC\u7684\u7814\u53d1\uff0c\u56fd\u5185\u4f01\u4e1a\u7ecf\u5386\u4e86\u8d76\u8dd1\u548c\u5e76\u8dd1\u7684\u9636\u6bb5\uff0c\u73b0\u5982\u4eca\u5df2\u7ecf\u6210\u4e3a\u5168\u7403ADC\u521b\u65b0\u6280\u672f\u7684\u91cd\u8981\u529b\u91cf\uff0c\u76f8\u4fe1\u7ec8\u6709\u4e00\u65e5\uff0c\u665a\u671f\u4e09\u9634\u4e73\u817a\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7ADC\u521b\u65b0\u836f\u7269\u83b7\u5f97\u66f4\u52a0\u6709\u6548\u7684\u6cbb\u7597\u3002”<\/p>\n

NSCLC<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u4e8e9\u670828\u65e5\u4e0b\u5348\uff0c\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u7684\u65b9\u6587\u5cf0\u6559\u6388\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u53e3\u5934\u62a5\u544a\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408KL-A167\uff08\u6297PD-L1\u5355\u6297\uff09\u4e00\u7ebf\u6cbb\u7597\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff1aOptiTROP-Lung01 II\u671f\u7814\u7a76\u7ed3\u679c\u5e76\u8fdb\u884c\u4e86\u8bba\u6587\u8ba8\u8bba\u3002<\/p>\n

\u7814\u7a76\u4ee5\u975e\u968f\u673a\u65b9\u5f0f\u63a5\u53d7sac-TMT 5 mg\/kg Q3W + KL-A167 1200 mg Q3W\uff08\u961f\u52171A\uff0c40\u4f8b\u60a3\u8005\uff09\u6216sac-TMT 5 mg\/kg Q2W + KL-A167 900 mg Q2W\uff08\u961f\u52171B\uff0c63\u4f8b\u60a3\u8005\uff09\u6cbb\u7597\u3002\u961f\u52171A \u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a14.0\u4e2a\u6708\uff0cORR\u4e3a48.6%\uff0818\/ 37\uff0c2\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR \u4e3a94.6%\uff0c\u4e2d\u4f4dPFS\u4e3a15.4\u4e2a\u6708\uff0895% CI: 6.7, NE\uff09\uff0c6\u4e2a\u6708PFS\u7387\u4e3a69.2%\uff1b\u961f\u52171B\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.9\u4e2a\u6708\uff0cORR\u4e3a77.6%\uff0845\/58\uff0c5\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR\u4e3a100.0%\uff0c\u4e2d\u4f4dPFS\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a84.6%\u3002\u961f\u52171B\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u548c\u7ec4\u7ec7\u5b66\u7c7b\u578b\u4e2d\u5747\u8868\u73b0\u51fa\u79ef\u6781\u7684\u6297\u80bf\u7624\u7597\u6548\u3002<\/p>\n

\u65b9\u6587\u5cf0\u6559\u6388\u8868\u793a\uff1a”ADC\u836f\u7269\u7684\u51fa\u73b0\uff0c\u5177\u6709\u5212\u65f6\u4ee3\u610f\u4e49\u3002\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u53cc\u836f\u65b9\u6848\u6b63\u5728\u5f15\u9886\u665a\u671fNSCLC\u4e00\u7ebf\u6cbb\u7597\u63a2\u7d22\u7684\u65b0\u65b9\u5411\uff0c\u521d\u6b65\u7814\u7a76\u6570\u636e\u89c2\u5bdf\u5230\u4e86\u975e\u5e38\u60ca\u8273\u7684\u7597\u6548\u3002\u672a\u6765\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5728NSCLC\u6cbb\u7597\u9886\u57df\u5e94\u7528\u6f5c\u529b\u503c\u5f97\u671f\u5f85\uff0c\u65e0\u8bba\u662f\u5728\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u8fd8\u662fEGFR\u7a81\u53d8\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u671b\u4e3a\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u591a\u6837\u5316\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\u3002”<\/p>\n

CC<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

9\u670828\u65e5\u4e0a\u5348\uff0c\u6e56\u5357\u7701\u80bf\u7624\u533b\u9662\u7684\u738b\u9759\u6559\u6388\u5728\u5927\u4f1a\u8bba\u6587\u53e3\u5934\u62a5\u544a\u4e13\u573a\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u53ef\u745e\u8fbe\u00ae\uff09\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c(CC)\u60a3\u8005\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002\u7814\u7a76\u7eb3\u5165\u4e86\u542b\u94c2\u53cc\u836f\u5316\u7597\u5931\u8d25\u76842\u7ebf\u62163\u7ebf\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u60a3\u8005\uff0c 38\u4f8b\u60a3\u8005\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.2\u4e2a\u6708\uff0cORR\u4e3a57.9%\uff0822\/38\uff0c3\u4f8b\u672a\u786e\u8ba4\uff09\u3002\u5728\u63a5\u53d7\u6297PD-1\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u4ea6\u89c2\u5bdf\u5230\u7f13\u89e3\uff08ORR\u4e3a68.8%\uff0c11\/16\uff09\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a65.7%\u3002<\/p>\n

\u738b\u9759\u6559\u6388\u8868\u793a\uff1a”\u5bab\u9888\u764c\u9ad8\u8868\u8fbeTROP2\uff0c\u65e2\u5f80\u7814\u7a76\u63d0\u793a\u8fc7\u8868\u8fbe\u6bd4\u4f8b\u8fbe90%\u4ee5\u4e0a\uff0cTROP2\u9ad8\u8868\u8fbe\u4e0e\u80bf\u7624\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u5bc6\u5207\u76f8\u5173\uff0c\u4e5f\u53ef\u80fd\u548c\u90e8\u5206\u836f\u7269\u6cbb\u7597\u654f\u611f\u6027\u76f8\u5173\uff0c\u662f\u4e00\u4e2a\u5f88\u597d\u63a2\u7d22\u9776\u70b9\u3002\u76f8\u4fe1\u968f\u7740\u8fd9\u4e9b\u53ef\u559c\u6210\u679c\u7684\u51fa\u73b0\uff0c\u672a\u6765\u5987\u79d1\u80bf\u7624\u9886\u57df\u4f1a\u6709\u66f4\u591a\u7684\u7814\u7a76\u6d8c\u73b0\u6765\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u4e3a\u66f4\u5e7f\u6cdb\u7684\u764c\u75c7\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002”<\/p>\n

EC\/OC<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

9\u670828\u65e5\u4e0a\u5348\uff0c\u8fbd\u5b81\u7701\u80bf\u7624\u533b\u9662\u7684\u6768\u5353\u535a\u58eb\u5728\u53e3\u5934\u62a5\u544a\u73af\u8282\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c(EC)\u548c\u5375\u5de2\u764c(OC)\u4e2d\u7684\u7814\u7a76\u7ed3\u679c\u3002\u572844\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u961f\u5217\u4e2d\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a7.2\u4e2a\u6708\u300252.3%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u6216\u4ee5\u4e0a\u7684\u6cbb\u7597\uff0c\u57fa\u7ebf\u76f8\u5bf9\u8f83\u5dee\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u4ecd\u53ef\u53d6\u5f9734.1%\uff0815\/44\uff0c\u5176\u4e2d3\u4f8b\u5f85\u786e\u8ba4\uff09\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c75%\u7684\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5219\u4e3a5.7\u4e2a\u6708\uff0895% CI\uff1a3.7\uff0c9.4\uff09\uff0c6\u4e2a\u6708PFS\u7387\u4e3a47.5%\u3002\u572840\u4f8b\u5375\u5de2\u764c\u961f\u5217\u4e2d\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u957f\u8fbe28.2\u4e2a\u6708\uff0c\u4e14\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u6216\u4ee5\u4e0a\u6cbb\u7597\uff0c\u5176\u4e2d87.5%\u7684\u60a3\u8005\u4e3a\u94c2\u7c7b\u8010\u836f\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u53d6\u5f97\u4e8640%\u7684ORR\uff0814\/40\uff09\u548c75%\u7684DCR\uff0c\u4e2d\u4f4dPFS\u4e3a6\u4e2a\u6708\uff0cmOS\u4e3a16.1\u4e2a\u6708\uff0895% CI\uff1a10.5\uff0cNE\uff09\u3002<\/p>\n

\u70b9\u8bc4\u73af\u8282\uff0c\u8fbd\u5b81\u7701\u80bf\u7624\u533b\u9662\u738b\u4e39\u6ce2\u6559\u6388\u8868\u793a\uff1a”\u5375\u5de2\u764c\u4e0e\u5b50\u5bab\u5185\u819c\u764c\u5728\u6d41\u884c\u75c5\u5b66\u4e0a\u5404\u5177\u7279\u8272\uff0c\u6211\u56fd\u53d1\u8fbe\u57ce\u5e02\u7684\u5b50\u5bab\u5185\u819c\u764c\u53d1\u75c5\u7387\u4ea6\u9010\u5e74\u6500\u5347\uff0c\u672a\u6765\u53ef\u80fd\u4f1a\u6210\u4e3a\u4e2d\u56fd\u5973\u6027\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u9996\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5375\u5de2\u764c\u6700\u4e3a\u663e\u8457\u7684\u7279\u5f81\u662f\u53d1\u75c5\u9690\u533f\u3001\u665a\u671f\u53d1\u73b0\u7387\u9ad8\u53ca\u9ad8\u6b7b\u4ea1\u7387\uff0c\u63a2\u7d22\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u4ee5\u514b\u670d\u94c2\u8010\u836f\u3001\u63d0\u9ad8\u5375\u5de2\u764c\u60a3\u8005\u751f\u5b58\u7387\uff0c\u662f\u672a\u6765\u7814\u7a76\u7684\u91cd\u70b9\u65b9\u5411\u3002\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5728\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u548c\u5375\u5de2\u764c\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5b83\u4e0d\u4ec5\u5728\u7597\u6548\u4e0a\u53d6\u5f97\u4e86\u663e\u8457\u6210\u679c\uff0c\u800c\u4e14\u5b89\u5168\u6027\u4e5f\u5f97\u5230\u4e86\u826f\u597d\u63a7\u5236\u3002\u6211\u76f8\u4fe1\uff0c\u5728\u672a\u6765\u7684\u7814\u7a76\u548c\u5e94\u7528\u4e2d\uff0c\u5b83\u5c06\u6210\u4e3aADC\u521b\u65b0\u836f\u7814\u53d1\u9886\u57df\u7684\u4f7c\u4f7c\u8005\uff0c\u4e3a\u66f4\u591a\u5987\u79d1\u80bf\u7624\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b\u3002”<\/p>\n

\u79d1\u4f26\u535a\u6cf0\u59cb\u7ec8\u80f8\u6000\u535a\u7231\u4e4b\u5fc3\uff0c\u81f4\u529b\u4e8e\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u901a\u8fc7\u805a\u7126\u81ea\u8eab\u6280\u672f\u4f18\u52bf\uff0c\u4e3a\u56fd\u5185\u60a3\u8005\u63d0\u4f9b\u4e34\u5e8a\u4ef7\u503c\u663e\u8457\u4e14\u6027\u4ef7\u6bd4\u4f18\u5f02\u7684\u65b0\u578bADC\u836f\u7269\uff0c\u63d0\u5347\u4e34\u5e8a\u60a3\u8005\u83b7\u76ca\u3002\u672a\u6765\uff0c\u5c06\u4e0d\u65ad\u52a0\u901f\u5019\u9009\u836f\u7269\u7684\u7814\u53d1\u53ca\u4e34\u5e8a\u8fdb\u5ea6\uff0c\u63d0\u5347\u4e00\u4f53\u5316\u836f\u7269\u5f00\u53d1\u80fd\u529b\uff0c\u4e3a\u5b9e\u73b0\u5065\u5eb7\u4e2d\u56fd2030\u6dfb\u7816\u52a0\u74e6\u3002<\/p>\n

\n<\/div>\n

SOURCE \u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"

\u6210\u90fd2024\u5e749\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — 9\u670825\u65e5\u81f329\u65e5\uff0c\u7b2c27\u5c4a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u5927\u4f1a\u66a82024\u5e74CSCO\u5b66\u672f\u5e74\u4f1a\u5728\u53a6\u95e8\u9686\u91cd\u53ec\u5f00\u3002\u6765\u81ea\u5168\u56fd\u80bf\u7624\u9886\u57df\u7684\u4e13\u5bb6\u5b66\u8005\u9f50\u805a\u4e00\u5802\uff0c\u5171\u540c\u63a2\u8ba8\u4e34\u5e8a\u5b9e\u8df5\u7684\u524d\u6cbf\u70ed\u70b9\u3002\u4e8e\u5927\u4f1a\u4e0a\uff0c\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0”\u79d1\u4f26\u535a\u6cf0”\uff0c6990.HK\uff09\u53d1\u8868\u4e86TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297(sac-TMT)\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53ca\u8fdb\u5c55\u3002 TNBC 9\u670827\u65e5\u4e0b\u5348\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u7684\u5f90\u5175\u6cb3\u9662\u58eb\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u5c31\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u6cbb\u7597\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09OptiTROP-Breast01 III\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u4e86\u53e3\u5934\u62a5\u544a\u548c\u8bba\u6587\u8ba8\u8bba\u3002 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CI: 0.19, 0.46\uff09\u3002OS\u671f\u4e2d\u5206\u6790\u663e\u793a\uff0csac-TMT\u7ec4\u7684\u4e2d\u4f4dOS\u5c1a\u672a\u8fbe\u5230\uff0895% CI\uff1a11.2\uff0cNE\uff09\uff0c\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a9.4\u4e2a\u6708\uff0895% CI\uff1a8.5\uff0c11.7\uff09\uff1bHR\u4e3a0.53\uff0895% CI\uff1a0.36\uff0c0.78\uff09\uff08P=0.0005\uff09\uff0csac-TMT\u76f8\u6bd4\u5316\u7597\u53d1\u751f\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e47%\u3002\u4e0e\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u76f8\u6bd4\uff0csac-TMT\u6cbb\u7597\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684PFS\u548cOS\u5747\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\uff0c\u4e14\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u6709\u671b\u6210\u4e3a\u8fd9\u7c7b\u60a3\u8005\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002 \u5f90\u5175\u6cb3\u9662\u58eb\u8868\u793a\uff1a”\u4e73\u817a\u764c\u662f\u5168\u7403\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\uff0c\u5a01\u80c1\u7740\u5973\u6027\u7684\u751f\u547d\u5065\u5eb7\uff0c\u5176\u4e2d\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\u9884\u540e\u5dee\uff0c\u751f\u5b58\u671f\u77ed\u3002\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u672a\u6765\u7684\u6cbb\u7597\u53d1\u5c55\u65b9\u5411\u662f\u7cbe\u51c6\u5206\u5c42\u6cbb\u7597\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u52a9\u4e8e\u6ee1\u8db3\u60a3\u8005\u66f4\u591a\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u672a\u6765\u6216\u6709\u671b\u6210\u4e3a\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u3002\u5bf9\u4e8eADC\u7684\u7814\u53d1\uff0c\u56fd\u5185\u4f01\u4e1a\u7ecf\u5386\u4e86\u8d76\u8dd1\u548c\u5e76\u8dd1\u7684\u9636\u6bb5\uff0c\u73b0\u5982\u4eca\u5df2\u7ecf\u6210\u4e3a\u5168\u7403ADC\u521b\u65b0\u6280\u672f\u7684\u91cd\u8981\u529b\u91cf\uff0c\u76f8\u4fe1\u7ec8\u6709\u4e00\u65e5\uff0c\u665a\u671f\u4e09\u9634\u4e73\u817a\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7ADC\u521b\u65b0\u836f\u7269\u83b7\u5f97\u66f4\u52a0\u6709\u6548\u7684\u6cbb\u7597\u3002” NSCLC \u4e8e9\u670828\u65e5\u4e0b\u5348\uff0c\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u7684\u65b9\u6587\u5cf0\u6559\u6388\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u53e3\u5934\u62a5\u544a\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408KL-A167\uff08\u6297PD-L1\u5355\u6297\uff09\u4e00\u7ebf\u6cbb\u7597\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff1aOptiTROP-Lung01 II\u671f\u7814\u7a76\u7ed3\u679c\u5e76\u8fdb\u884c\u4e86\u8bba\u6587\u8ba8\u8bba\u3002 \u7814\u7a76\u4ee5\u975e\u968f\u673a\u65b9\u5f0f\u63a5\u53d7sac-TMT 5 mg\/kg Q3W + KL-A167 1200 mg Q3W\uff08\u961f\u52171A\uff0c40\u4f8b\u60a3\u8005\uff09\u6216sac-TMT 5 mg\/kg Q2W + KL-A167 900 mg Q2W\uff08\u961f\u52171B\uff0c63\u4f8b\u60a3\u8005\uff09\u6cbb\u7597\u3002\u961f\u52171A \u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a14.0\u4e2a\u6708\uff0cORR\u4e3a48.6%\uff0818\/ 37\uff0c2\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR \u4e3a94.6%\uff0c\u4e2d\u4f4dPFS\u4e3a15.4\u4e2a\u6708\uff0895% CI: 6.7, NE\uff09\uff0c6\u4e2a\u6708PFS\u7387\u4e3a69.2%\uff1b\u961f\u52171B\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.9\u4e2a\u6708\uff0cORR\u4e3a77.6%\uff0845\/58\uff0c5\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR\u4e3a100.0%\uff0c\u4e2d\u4f4dPFS\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a84.6%\u3002\u961f\u52171B\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u548c\u7ec4\u7ec7\u5b66\u7c7b\u578b\u4e2d\u5747\u8868\u73b0\u51fa\u79ef\u6781\u7684\u6297\u80bf\u7624\u7597\u6548\u3002 \u65b9\u6587\u5cf0\u6559\u6388\u8868\u793a\uff1a”ADC\u836f\u7269\u7684\u51fa\u73b0\uff0c\u5177\u6709\u5212\u65f6\u4ee3\u610f\u4e49\u3002\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u53cc\u836f\u65b9\u6848\u6b63\u5728\u5f15\u9886\u665a\u671fNSCLC\u4e00\u7ebf\u6cbb\u7597\u63a2\u7d22\u7684\u65b0\u65b9\u5411\uff0c\u521d\u6b65\u7814\u7a76\u6570\u636e\u89c2\u5bdf\u5230\u4e86\u975e\u5e38\u60ca\u8273\u7684\u7597\u6548\u3002\u672a\u6765\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5728NSCLC\u6cbb\u7597\u9886\u57df\u5e94\u7528\u6f5c\u529b\u503c\u5f97\u671f\u5f85\uff0c\u65e0\u8bba\u662f\u5728\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u8fd8\u662fEGFR\u7a81\u53d8\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u671b\u4e3a\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u591a\u6837\u5316\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\u3002” CC 9\u670828\u65e5\u4e0a\u5348\uff0c\u6e56\u5357\u7701\u80bf\u7624\u533b\u9662\u7684\u738b\u9759\u6559\u6388\u5728\u5927\u4f1a\u8bba\u6587\u53e3\u5934\u62a5\u544a\u4e13\u573a\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u53ef\u745e\u8fbe\u00ae\uff09\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c(CC)\u60a3\u8005\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002\u7814\u7a76\u7eb3\u5165\u4e86\u542b\u94c2\u53cc\u836f\u5316\u7597\u5931\u8d25\u76842\u7ebf\u62163\u7ebf\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u60a3\u8005\uff0c 38\u4f8b\u60a3\u8005\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.2\u4e2a\u6708\uff0cORR\u4e3a57.9%\uff0822\/38\uff0c3\u4f8b\u672a\u786e\u8ba4\uff09\u3002\u5728\u63a5\u53d7\u6297PD-1\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u4ea6\u89c2\u5bdf\u5230\u7f13\u89e3\uff08ORR\u4e3a68.8%\uff0c11\/16\uff09\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a65.7%\u3002 \u738b\u9759\u6559\u6388\u8868\u793a\uff1a”\u5bab\u9888\u764c\u9ad8\u8868\u8fbeTROP2\uff0c\u65e2\u5f80\u7814\u7a76\u63d0\u793a\u8fc7\u8868\u8fbe\u6bd4\u4f8b\u8fbe90%\u4ee5\u4e0a\uff0cTROP2\u9ad8\u8868\u8fbe\u4e0e\u80bf\u7624\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u5bc6\u5207\u76f8\u5173\uff0c\u4e5f\u53ef\u80fd\u548c\u90e8\u5206\u836f\u7269\u6cbb\u7597\u654f\u611f\u6027\u76f8\u5173\uff0c\u662f\u4e00\u4e2a\u5f88\u597d\u63a2\u7d22\u9776\u70b9\u3002\u76f8\u4fe1\u968f\u7740\u8fd9\u4e9b\u53ef\u559c\u6210\u679c\u7684\u51fa\u73b0\uff0c\u672a\u6765\u5987\u79d1\u80bf\u7624\u9886\u57df\u4f1a\u6709\u66f4\u591a\u7684\u7814\u7a76\u6d8c\u73b0\u6765\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u4e3a\u66f4\u5e7f\u6cdb\u7684\u764c\u75c7\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002” EC\/OC 9\u670828\u65e5\u4e0a\u5348\uff0c\u8fbd\u5b81\u7701\u80bf\u7624\u533b\u9662\u7684\u6768\u5353\u535a\u58eb\u5728\u53e3\u5934\u62a5\u544a\u73af\u8282\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c(EC)\u548c\u5375\u5de2\u764c(OC)\u4e2d\u7684\u7814\u7a76\u7ed3\u679c\u3002\u572844\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u961f\u5217\u4e2d\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a7.2\u4e2a\u6708\u300252.3%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u6216\u4ee5\u4e0a\u7684\u6cbb\u7597\uff0c\u57fa\u7ebf\u76f8\u5bf9\u8f83\u5dee\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u4ecd\u53ef\u53d6\u5f9734.1%\uff0815\/44\uff0c\u5176\u4e2d3\u4f8b\u5f85\u786e\u8ba4\uff09\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c75%\u7684\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5219\u4e3a5.7\u4e2a\u6708\uff0895% CI\uff1a3.7\uff0c9.4\uff09\uff0c6\u4e2a\u6708PFS\u7387\u4e3a47.5%\u3002\u572840\u4f8b\u5375\u5de2\u764c\u961f\u5217\u4e2d\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u957f\u8fbe28.2\u4e2a\u6708\uff0c\u4e14\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u6216\u4ee5\u4e0a\u6cbb\u7597\uff0c\u5176\u4e2d87.5%\u7684\u60a3\u8005\u4e3a\u94c2\u7c7b\u8010\u836f\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u53d6\u5f97\u4e8640%\u7684ORR\uff0814\/40\uff09\u548c75%\u7684DCR\uff0c\u4e2d\u4f4dPFS\u4e3a6\u4e2a\u6708\uff0cmOS\u4e3a16.1\u4e2a\u6708\uff0895% CI\uff1a10.5\uff0cNE\uff09\u3002 \u70b9\u8bc4\u73af\u8282\uff0c\u8fbd\u5b81\u7701\u80bf\u7624\u533b\u9662\u738b\u4e39\u6ce2\u6559\u6388\u8868\u793a\uff1a”\u5375\u5de2\u764c\u4e0e\u5b50\u5bab\u5185\u819c\u764c\u5728\u6d41\u884c\u75c5\u5b66\u4e0a\u5404\u5177\u7279\u8272\uff0c\u6211\u56fd\u53d1\u8fbe\u57ce\u5e02\u7684\u5b50\u5bab\u5185\u819c\u764c\u53d1\u75c5\u7387\u4ea6\u9010\u5e74\u6500\u5347\uff0c\u672a\u6765\u53ef\u80fd\u4f1a\u6210\u4e3a\u4e2d\u56fd\u5973\u6027\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u9996\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5375\u5de2\u764c\u6700\u4e3a\u663e\u8457\u7684\u7279\u5f81\u662f\u53d1\u75c5\u9690\u533f\u3001\u665a\u671f\u53d1\u73b0\u7387\u9ad8\u53ca\u9ad8\u6b7b\u4ea1\u7387\uff0c\u63a2\u7d22\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u4ee5\u514b\u670d\u94c2\u8010\u836f\u3001\u63d0\u9ad8\u5375\u5de2\u764c\u60a3\u8005\u751f\u5b58\u7387\uff0c\u662f\u672a\u6765\u7814\u7a76\u7684\u91cd\u70b9\u65b9\u5411\u3002\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5728\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u548c\u5375\u5de2\u764c\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5b83\u4e0d\u4ec5\u5728\u7597\u6548\u4e0a\u53d6\u5f97\u4e86\u663e\u8457\u6210\u679c\uff0c\u800c\u4e14\u5b89\u5168\u6027\u4e5f\u5f97\u5230\u4e86\u826f\u597d\u63a7\u5236\u3002\u6211\u76f8\u4fe1\uff0c\u5728\u672a\u6765\u7684\u7814\u7a76\u548c\u5e94\u7528\u4e2d\uff0c\u5b83\u5c06\u6210\u4e3aADC\u521b\u65b0\u836f\u7814\u53d1\u9886\u57df\u7684\u4f7c\u4f7c\u8005\uff0c\u4e3a\u66f4\u591a\u5987\u79d1\u80bf\u7624\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b\u3002” […]<\/p>\n","protected":false},"author":0,"featured_media":1783,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-1782","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u79d1\u4f26\u535a\u6cf0TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u4eae\u76f8CSCO - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u79d1\u4f26\u535a\u6cf0trop2-adc\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-tmt\uff09\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u79d1\u4f26\u535a\u6cf0TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u4eae\u76f8CSCO - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u6210\u90fd2024\u5e749\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — 9\u670825\u65e5\u81f329\u65e5\uff0c\u7b2c27\u5c4a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u5927\u4f1a\u66a82024\u5e74CSCO\u5b66\u672f\u5e74\u4f1a\u5728\u53a6\u95e8\u9686\u91cd\u53ec\u5f00\u3002\u6765\u81ea\u5168\u56fd\u80bf\u7624\u9886\u57df\u7684\u4e13\u5bb6\u5b66\u8005\u9f50\u805a\u4e00\u5802\uff0c\u5171\u540c\u63a2\u8ba8\u4e34\u5e8a\u5b9e\u8df5\u7684\u524d\u6cbf\u70ed\u70b9\u3002\u4e8e\u5927\u4f1a\u4e0a\uff0c\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0”\u79d1\u4f26\u535a\u6cf0”\uff0c6990.HK\uff09\u53d1\u8868\u4e86TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297(sac-TMT)\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53ca\u8fdb\u5c55\u3002 TNBC 9\u670827\u65e5\u4e0b\u5348\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u7684\u5f90\u5175\u6cb3\u9662\u58eb\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u5c31\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u6cbb\u7597\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09OptiTROP-Breast01 III\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u4e86\u53e3\u5934\u62a5\u544a\u548c\u8bba\u6587\u8ba8\u8bba\u3002 \u6839\u636e\u76f2\u6001\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08BICR\uff09\u7684\u8bc4\u4f30\u7ed3\u679c\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u7ec4\uff08130\u4f8b\uff09\u4e2d\u4f4dPFS\u4e3a6.7\u4e2a\u6708\uff0c\u5316\u7597\u7ec4\uff08133\u4f8b\uff09\u4e3a2.5\u4e2a\u6708\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u76f8\u6bd4\u5316\u7597\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e68%\uff08HR=0.32\uff0c95% CI\uff1a0.22\uff5e0.44\uff09\u3002\u4e0e\u5316\u7597\u7ec4\u76f8\u6bd4\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u7ec4\u5728\u5404\u4e9a\u7ec4\u4e2dPFS\u5747\u663e\u8457\u5ef6\u957f\uff0c\u4e0e\u603b\u4f53\u4eba\u7fa4\u83b7\u76ca\u4e00\u81f4\u3002\u5728TROP2\u9ad8\u8868\u8fbe\uff08H\u8bc4\u5206>200\uff09\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u66f4\u597d\u7684PFS\u83b7\u76ca\u8d8b\u52bf\uff0csac-TMT\u7ec4\u548c\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dPFS\u5206\u522b\u4e3a8.3\u548c2.3\u4e2a\u6708\uff08HR 0.29 \uff0c95% CI: 0.19, 0.46\uff09\u3002OS\u671f\u4e2d\u5206\u6790\u663e\u793a\uff0csac-TMT\u7ec4\u7684\u4e2d\u4f4dOS\u5c1a\u672a\u8fbe\u5230\uff0895% CI\uff1a11.2\uff0cNE\uff09\uff0c\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a9.4\u4e2a\u6708\uff0895% CI\uff1a8.5\uff0c11.7\uff09\uff1bHR\u4e3a0.53\uff0895% CI\uff1a0.36\uff0c0.78\uff09\uff08P=0.0005\uff09\uff0csac-TMT\u76f8\u6bd4\u5316\u7597\u53d1\u751f\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e47%\u3002\u4e0e\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u76f8\u6bd4\uff0csac-TMT\u6cbb\u7597\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684PFS\u548cOS\u5747\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\uff0c\u4e14\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u6709\u671b\u6210\u4e3a\u8fd9\u7c7b\u60a3\u8005\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002 \u5f90\u5175\u6cb3\u9662\u58eb\u8868\u793a\uff1a”\u4e73\u817a\u764c\u662f\u5168\u7403\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\uff0c\u5a01\u80c1\u7740\u5973\u6027\u7684\u751f\u547d\u5065\u5eb7\uff0c\u5176\u4e2d\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\u9884\u540e\u5dee\uff0c\u751f\u5b58\u671f\u77ed\u3002\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u672a\u6765\u7684\u6cbb\u7597\u53d1\u5c55\u65b9\u5411\u662f\u7cbe\u51c6\u5206\u5c42\u6cbb\u7597\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u52a9\u4e8e\u6ee1\u8db3\u60a3\u8005\u66f4\u591a\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u672a\u6765\u6216\u6709\u671b\u6210\u4e3a\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u3002\u5bf9\u4e8eADC\u7684\u7814\u53d1\uff0c\u56fd\u5185\u4f01\u4e1a\u7ecf\u5386\u4e86\u8d76\u8dd1\u548c\u5e76\u8dd1\u7684\u9636\u6bb5\uff0c\u73b0\u5982\u4eca\u5df2\u7ecf\u6210\u4e3a\u5168\u7403ADC\u521b\u65b0\u6280\u672f\u7684\u91cd\u8981\u529b\u91cf\uff0c\u76f8\u4fe1\u7ec8\u6709\u4e00\u65e5\uff0c\u665a\u671f\u4e09\u9634\u4e73\u817a\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7ADC\u521b\u65b0\u836f\u7269\u83b7\u5f97\u66f4\u52a0\u6709\u6548\u7684\u6cbb\u7597\u3002” NSCLC \u4e8e9\u670828\u65e5\u4e0b\u5348\uff0c\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u7684\u65b9\u6587\u5cf0\u6559\u6388\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u53e3\u5934\u62a5\u544a\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408KL-A167\uff08\u6297PD-L1\u5355\u6297\uff09\u4e00\u7ebf\u6cbb\u7597\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff1aOptiTROP-Lung01 II\u671f\u7814\u7a76\u7ed3\u679c\u5e76\u8fdb\u884c\u4e86\u8bba\u6587\u8ba8\u8bba\u3002 \u7814\u7a76\u4ee5\u975e\u968f\u673a\u65b9\u5f0f\u63a5\u53d7sac-TMT 5 mg\/kg Q3W + KL-A167 1200 mg Q3W\uff08\u961f\u52171A\uff0c40\u4f8b\u60a3\u8005\uff09\u6216sac-TMT 5 mg\/kg Q2W + KL-A167 900 mg Q2W\uff08\u961f\u52171B\uff0c63\u4f8b\u60a3\u8005\uff09\u6cbb\u7597\u3002\u961f\u52171A \u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a14.0\u4e2a\u6708\uff0cORR\u4e3a48.6%\uff0818\/ 37\uff0c2\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR \u4e3a94.6%\uff0c\u4e2d\u4f4dPFS\u4e3a15.4\u4e2a\u6708\uff0895% CI: 6.7, NE\uff09\uff0c6\u4e2a\u6708PFS\u7387\u4e3a69.2%\uff1b\u961f\u52171B\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.9\u4e2a\u6708\uff0cORR\u4e3a77.6%\uff0845\/58\uff0c5\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR\u4e3a100.0%\uff0c\u4e2d\u4f4dPFS\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a84.6%\u3002\u961f\u52171B\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u548c\u7ec4\u7ec7\u5b66\u7c7b\u578b\u4e2d\u5747\u8868\u73b0\u51fa\u79ef\u6781\u7684\u6297\u80bf\u7624\u7597\u6548\u3002 \u65b9\u6587\u5cf0\u6559\u6388\u8868\u793a\uff1a”ADC\u836f\u7269\u7684\u51fa\u73b0\uff0c\u5177\u6709\u5212\u65f6\u4ee3\u610f\u4e49\u3002\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u53cc\u836f\u65b9\u6848\u6b63\u5728\u5f15\u9886\u665a\u671fNSCLC\u4e00\u7ebf\u6cbb\u7597\u63a2\u7d22\u7684\u65b0\u65b9\u5411\uff0c\u521d\u6b65\u7814\u7a76\u6570\u636e\u89c2\u5bdf\u5230\u4e86\u975e\u5e38\u60ca\u8273\u7684\u7597\u6548\u3002\u672a\u6765\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5728NSCLC\u6cbb\u7597\u9886\u57df\u5e94\u7528\u6f5c\u529b\u503c\u5f97\u671f\u5f85\uff0c\u65e0\u8bba\u662f\u5728\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u8fd8\u662fEGFR\u7a81\u53d8\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u671b\u4e3a\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u591a\u6837\u5316\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\u3002” CC 9\u670828\u65e5\u4e0a\u5348\uff0c\u6e56\u5357\u7701\u80bf\u7624\u533b\u9662\u7684\u738b\u9759\u6559\u6388\u5728\u5927\u4f1a\u8bba\u6587\u53e3\u5934\u62a5\u544a\u4e13\u573a\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u53ef\u745e\u8fbe\u00ae\uff09\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c(CC)\u60a3\u8005\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002\u7814\u7a76\u7eb3\u5165\u4e86\u542b\u94c2\u53cc\u836f\u5316\u7597\u5931\u8d25\u76842\u7ebf\u62163\u7ebf\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u60a3\u8005\uff0c 38\u4f8b\u60a3\u8005\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.2\u4e2a\u6708\uff0cORR\u4e3a57.9%\uff0822\/38\uff0c3\u4f8b\u672a\u786e\u8ba4\uff09\u3002\u5728\u63a5\u53d7\u6297PD-1\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u4ea6\u89c2\u5bdf\u5230\u7f13\u89e3\uff08ORR\u4e3a68.8%\uff0c11\/16\uff09\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a65.7%\u3002 \u738b\u9759\u6559\u6388\u8868\u793a\uff1a”\u5bab\u9888\u764c\u9ad8\u8868\u8fbeTROP2\uff0c\u65e2\u5f80\u7814\u7a76\u63d0\u793a\u8fc7\u8868\u8fbe\u6bd4\u4f8b\u8fbe90%\u4ee5\u4e0a\uff0cTROP2\u9ad8\u8868\u8fbe\u4e0e\u80bf\u7624\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u5bc6\u5207\u76f8\u5173\uff0c\u4e5f\u53ef\u80fd\u548c\u90e8\u5206\u836f\u7269\u6cbb\u7597\u654f\u611f\u6027\u76f8\u5173\uff0c\u662f\u4e00\u4e2a\u5f88\u597d\u63a2\u7d22\u9776\u70b9\u3002\u76f8\u4fe1\u968f\u7740\u8fd9\u4e9b\u53ef\u559c\u6210\u679c\u7684\u51fa\u73b0\uff0c\u672a\u6765\u5987\u79d1\u80bf\u7624\u9886\u57df\u4f1a\u6709\u66f4\u591a\u7684\u7814\u7a76\u6d8c\u73b0\u6765\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u4e3a\u66f4\u5e7f\u6cdb\u7684\u764c\u75c7\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002” EC\/OC 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\u5f90\u5175\u6cb3\u9662\u58eb\u8868\u793a\uff1a”\u4e73\u817a\u764c\u662f\u5168\u7403\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\uff0c\u5a01\u80c1\u7740\u5973\u6027\u7684\u751f\u547d\u5065\u5eb7\uff0c\u5176\u4e2d\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\u9884\u540e\u5dee\uff0c\u751f\u5b58\u671f\u77ed\u3002\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u672a\u6765\u7684\u6cbb\u7597\u53d1\u5c55\u65b9\u5411\u662f\u7cbe\u51c6\u5206\u5c42\u6cbb\u7597\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u52a9\u4e8e\u6ee1\u8db3\u60a3\u8005\u66f4\u591a\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u672a\u6765\u6216\u6709\u671b\u6210\u4e3a\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u3002\u5bf9\u4e8eADC\u7684\u7814\u53d1\uff0c\u56fd\u5185\u4f01\u4e1a\u7ecf\u5386\u4e86\u8d76\u8dd1\u548c\u5e76\u8dd1\u7684\u9636\u6bb5\uff0c\u73b0\u5982\u4eca\u5df2\u7ecf\u6210\u4e3a\u5168\u7403ADC\u521b\u65b0\u6280\u672f\u7684\u91cd\u8981\u529b\u91cf\uff0c\u76f8\u4fe1\u7ec8\u6709\u4e00\u65e5\uff0c\u665a\u671f\u4e09\u9634\u4e73\u817a\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7ADC\u521b\u65b0\u836f\u7269\u83b7\u5f97\u66f4\u52a0\u6709\u6548\u7684\u6cbb\u7597\u3002” NSCLC \u4e8e9\u670828\u65e5\u4e0b\u5348\uff0c\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u7684\u65b9\u6587\u5cf0\u6559\u6388\u4e8e\u521b\u65b0\u836f\u7269\u4e34\u5e8a\u6570\u636e\u4e13\u573a\u53e3\u5934\u62a5\u544a\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408KL-A167\uff08\u6297PD-L1\u5355\u6297\uff09\u4e00\u7ebf\u6cbb\u7597\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff1aOptiTROP-Lung01 II\u671f\u7814\u7a76\u7ed3\u679c\u5e76\u8fdb\u884c\u4e86\u8bba\u6587\u8ba8\u8bba\u3002 \u7814\u7a76\u4ee5\u975e\u968f\u673a\u65b9\u5f0f\u63a5\u53d7sac-TMT 5 mg\/kg Q3W + KL-A167 1200 mg Q3W\uff08\u961f\u52171A\uff0c40\u4f8b\u60a3\u8005\uff09\u6216sac-TMT 5 mg\/kg Q2W + KL-A167 900 mg Q2W\uff08\u961f\u52171B\uff0c63\u4f8b\u60a3\u8005\uff09\u6cbb\u7597\u3002\u961f\u52171A \u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a14.0\u4e2a\u6708\uff0cORR\u4e3a48.6%\uff0818\/ 37\uff0c2\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR \u4e3a94.6%\uff0c\u4e2d\u4f4dPFS\u4e3a15.4\u4e2a\u6708\uff0895% CI: 6.7, NE\uff09\uff0c6\u4e2a\u6708PFS\u7387\u4e3a69.2%\uff1b\u961f\u52171B\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.9\u4e2a\u6708\uff0cORR\u4e3a77.6%\uff0845\/58\uff0c5\u4f8b\u5f85\u786e\u8ba4\uff09\uff0cDCR\u4e3a100.0%\uff0c\u4e2d\u4f4dPFS\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a84.6%\u3002\u961f\u52171B\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u548c\u7ec4\u7ec7\u5b66\u7c7b\u578b\u4e2d\u5747\u8868\u73b0\u51fa\u79ef\u6781\u7684\u6297\u80bf\u7624\u7597\u6548\u3002 \u65b9\u6587\u5cf0\u6559\u6388\u8868\u793a\uff1a”ADC\u836f\u7269\u7684\u51fa\u73b0\uff0c\u5177\u6709\u5212\u65f6\u4ee3\u610f\u4e49\u3002\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u53cc\u836f\u65b9\u6848\u6b63\u5728\u5f15\u9886\u665a\u671fNSCLC\u4e00\u7ebf\u6cbb\u7597\u63a2\u7d22\u7684\u65b0\u65b9\u5411\uff0c\u521d\u6b65\u7814\u7a76\u6570\u636e\u89c2\u5bdf\u5230\u4e86\u975e\u5e38\u60ca\u8273\u7684\u7597\u6548\u3002\u672a\u6765\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u5728NSCLC\u6cbb\u7597\u9886\u57df\u5e94\u7528\u6f5c\u529b\u503c\u5f97\u671f\u5f85\uff0c\u65e0\u8bba\u662f\u5728\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u8fd8\u662fEGFR\u7a81\u53d8\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u6709\u671b\u4e3a\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u591a\u6837\u5316\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u83b7\u76ca\u3002” CC 9\u670828\u65e5\u4e0a\u5348\uff0c\u6e56\u5357\u7701\u80bf\u7624\u533b\u9662\u7684\u738b\u9759\u6559\u6388\u5728\u5927\u4f1a\u8bba\u6587\u53e3\u5934\u62a5\u544a\u4e13\u573a\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u53ef\u745e\u8fbe\u00ae\uff09\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c(CC)\u60a3\u8005\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002\u7814\u7a76\u7eb3\u5165\u4e86\u542b\u94c2\u53cc\u836f\u5316\u7597\u5931\u8d25\u76842\u7ebf\u62163\u7ebf\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u60a3\u8005\uff0c 38\u4f8b\u60a3\u8005\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.2\u4e2a\u6708\uff0cORR\u4e3a57.9%\uff0822\/38\uff0c3\u4f8b\u672a\u786e\u8ba4\uff09\u3002\u5728\u63a5\u53d7\u6297PD-1\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u4ea6\u89c2\u5bdf\u5230\u7f13\u89e3\uff08ORR\u4e3a68.8%\uff0c11\/16\uff09\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708PFS\u7387\u4e3a65.7%\u3002 \u738b\u9759\u6559\u6388\u8868\u793a\uff1a”\u5bab\u9888\u764c\u9ad8\u8868\u8fbeTROP2\uff0c\u65e2\u5f80\u7814\u7a76\u63d0\u793a\u8fc7\u8868\u8fbe\u6bd4\u4f8b\u8fbe90%\u4ee5\u4e0a\uff0cTROP2\u9ad8\u8868\u8fbe\u4e0e\u80bf\u7624\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u5bc6\u5207\u76f8\u5173\uff0c\u4e5f\u53ef\u80fd\u548c\u90e8\u5206\u836f\u7269\u6cbb\u7597\u654f\u611f\u6027\u76f8\u5173\uff0c\u662f\u4e00\u4e2a\u5f88\u597d\u63a2\u7d22\u9776\u70b9\u3002\u76f8\u4fe1\u968f\u7740\u8fd9\u4e9b\u53ef\u559c\u6210\u679c\u7684\u51fa\u73b0\uff0c\u672a\u6765\u5987\u79d1\u80bf\u7624\u9886\u57df\u4f1a\u6709\u66f4\u591a\u7684\u7814\u7a76\u6d8c\u73b0\u6765\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u4e3a\u66f4\u5e7f\u6cdb\u7684\u764c\u75c7\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002” EC\/OC 9\u670828\u65e5\u4e0a\u5348\uff0c\u8fbd\u5b81\u7701\u80bf\u7624\u533b\u9662\u7684\u6768\u5353\u535a\u58eb\u5728\u53e3\u5934\u62a5\u544a\u73af\u8282\u5206\u4eab\u4e86\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\uff08sac-TMT\uff09\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c(EC)\u548c\u5375\u5de2\u764c(OC)\u4e2d\u7684\u7814\u7a76\u7ed3\u679c\u3002\u572844\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u961f\u5217\u4e2d\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a7.2\u4e2a\u6708\u300252.3%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u6216\u4ee5\u4e0a\u7684\u6cbb\u7597\uff0c\u57fa\u7ebf\u76f8\u5bf9\u8f83\u5dee\uff0c\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u4ecd\u53ef\u53d6\u5f9734.1%\uff0815\/44\uff0c\u5176\u4e2d3\u4f8b\u5f85\u786e\u8ba4\uff09\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c75%\u7684\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5219\u4e3a5.7\u4e2a\u6708\uff0895% 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