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\n \u4e0a\u6d77<\/span>
\n 2025\u5e7411\u67087\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u7b2c\u516b\u5c4a\u4e2d\u56fd\u56fd\u9645\u8fdb\u53e3\u535a\u89c8\u4f1a\uff08\u4ee5\u4e0b\u7b80\u79f0”\u8fdb\u535a\u4f1a”\uff09\u671f\u95f4\uff0c\u8d5b\u8bfa\u83f2\u8fdb\u535a\u4f1a\u5f00\u9986\u4eea\u5f0f\u66a8\u5fc3\u8840\u7ba1\u9886\u57df\u521b\u65b0\u5168\u7403\u9996\u79c0\u4eea\u5f0f\u6b63\u5f0f\u4e3e\u884c\u3002\u8fde\u7eed\u516b\u5e74\u5168\u52e4\u53c2\u5c55\u8fdb\u535a\u4f1a\u7684\u8d5b\u8bfa\u83f2\u6b64\u6b21\u5e26\u6765\u4e86\u5fc3\u8840\u7ba1\u9886\u57df\u4e24\u5927\u521b\u65b0\u836f\u2014\u2014\u963f\u592b\u51ef\u6cf0\u7247\u548c\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7684\u5168\u7403\u9996\u79c0\u3002<\/p>\n

\n \u8d5b\u8bfa\u83f2\u666e\u836f\u4e2d\u56fd\u533a\u603b\u7ecf\u7406
\n Oxana Monge\u8868\u793a\uff1a”\u5728\u4e2d\u56fd\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u5df2\u6210\u4e3a\u5c45\u6c11\u7b2c\u4e00\u4f4d\u6b7b\u4ea1\u539f\u56e0[1]\uff0c\u5f71\u54cd\u6570\u4ee5\u4ebf\u8ba1\u7684\u5e7f\u5927\u4eba\u7fa4\u3002\u540c\u65f6\uff0c\u8d8a\u6765\u8d8a\u591a\u7ec6\u5206\u6cbb\u7597\u9886\u57df\u7684\u60a3\u8005\u9700\u6c42\u6b63\u5728\u51f8\u663e\u3002\u6b64\u6b21\u5168\u7403\u9996\u79c0\u7684\u4e24\u6b3e\u521b\u65b0\u4ea7\u54c1\u7a81\u7834\u73b0\u6709\u7684\u6cbb\u7597\u56f0\u5c40\uff0c\u6ee1\u8db3\u60a3\u8005\u6cbb\u7597\u7684\u672a\u5c3d\u4e4b\u9700\u3002\u4f5c\u4e3a\u7b2c\u4e8c\u4ee3\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\uff0c\u963f\u592b\u51ef\u6cf0\u7247\u662f\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u9886\u57df\u6f5c\u5728\u2018\u540c\u7c7b\u6700\u4f73’\u7684\u6cbb\u7597\u836f\u7269\uff0c\u80fd\u6253\u7834\u4f20\u7edf\u836f\u7269\u548c\u4fb5\u5165\u5f0f\u6cbb\u7597\u73b0\u6709\u7684\u5c40\u9650\u3002\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u662f\u5168\u7403\u9996\u4e2a\u4f5c\u7528\u4e8e\u521b\u65b0\u9776\u70b9APOC3 mRNA\u7684siRNA\u7c7b\u836f\u7269\uff0c\u4e3a\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\u548c\u4e25\u91cd\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u60a3\u8005\u6cbb\u7597\u5e26\u6765\u65b0\u5e0c\u671b\u3002\u671f\u5f85\u672c\u6b21\u4e24\u6b3e\u521b\u65b0\u4ea7\u54c1\u80fd\u591f\u501f\u52a9\u8fdb\u535a\u4f1a\u8fd9\u4e00\u521b\u65b0\u52a0\u901f\u5668\u548c\u5f3a\u5927\u7684\u2018\u6ea2\u51fa\u6548\u5e94’\uff0c\u65e9\u65e5\u5b9e\u73b0\u2018\u5c55\u54c1\u53d8\u5546\u54c1’\u7684\u8715\u53d8\uff0c\u66f4\u5feb\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005\u3002”<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\n \u6f5c\u5728
\n “
\n \u540c\u7c7b\u6700\u4f73
\n “
\n \uff1a\u963f\u592b\u51ef\u6cf0\u7247\u52a9\u529b\u5f00\u542f\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u9776\u5411\u6cbb\u7597
\n “
\n \u65b0\u65f6\u4ee3
\n ”\n <\/p>\n

\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u4f5c\u4e3a\u6700\u5e38\u89c1\u7684\u9057\u4f20\u6027\u5fc3\u810f\u75be\u75c5[2]\uff0c\u53ef\u80fd\u5f15\u53d1\u731d\u6b7b\u3001\u5fc3\u529b\u8870\u7aed\u3001\u8840\u6813\u6813\u585e\u7b49\u81f4\u547d\u98ce\u9669[3]\u3002\u8be5\u75be\u75c5\u662f\u9752\u5c11\u5e74\u548c\u8fd0\u52a8\u5458\u53d1\u751f\u5fc3\u810f\u6027\u731d\u6b7b\u6700\u5e38\u89c1\u7684\u75c5\u56e0\u4e4b\u4e00[3]\uff0c\u540c\u65f6\uff0c\u7ea643.5%\u7684\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u60a3\u8005\u4f1a\u8fdb\u5c55\u4e3a\u5c04\u8840\u5206\u6570\u4fdd\u7559\u7684\u5fc3\u529b\u8870\u7aed[4]\uff0c20%\u5de6\u53f3\u7684\u60a3\u8005\u4f1a\u53d1\u751f\u623f\u98a4\uff0c\u800c\u623f\u98a4\u662fHCM\u60a3\u8005\u8840\u6813\u6813\u585e\u7684\u6700\u5e38\u89c1\u539f\u56e0[4]\u3002<\/p>\n

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\n \u4e2d\u534e\u533b\u5b66\u4f1a
\n \u5fc3\u8840
\n \u7ba1\u75c5\u5206\u4f1a\u5e38\u52a1\u59d4\u5458\u53ca
\n \u5fc3
\n \u808c\u75c5\u5b66\u7ec4\u7ec4
\n \u957f
\n \u3001
\n \u2fb8
\n \u90fd\u533b\u79d1
\n \u5927
\n \u5b66\u9644\u5c5e\u5317\u4eac\u5b89\u8d1e\u533b\u9662
\n \u2f3c
\n \u8870\u4e0e
\n \u5fc3
\n \u808c\u75c5\u4e2d
\n \u5fc3
\n \u4e3b\u4efb\u533b\u5e08\u8463\u5efa\u589e\u6559\u6388\u8868\u793a\uff1a”\u76ee\u524d\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u6cbb\u7597\u91cd\u5fc3\u5df2\u7ecf\u4ece\u5355\u7eaf\u7684\u75c7\u72b6\u7f13\u89e3\u53d1\u5c55\u5230\u5feb\u901f\u8fbe\u6210\u591a\u4e2a\u91cd\u8981\u6cbb\u7597\u76ee\u6807\uff0c\u4f8b\u5982\u5feb\u901f\u964d\u4f4eLVOT-G\uff0c\u6709\u52a9\u4e8e\u7f13\u89e3\u5de6\u5fc3\u5ba4\u6d41\u51fa\u9053\u6897\u963b\uff0c\u4ece\u800c\u964d\u4f4e\u5fc3\u6e90\u6027\u731d\u6b7b\u7684\u98ce\u9669\u3002\u7136\u800c\u5927\u90e8\u5206\u5728\u6cbb\u7597\u4e2d\u5bb9\u6613\u9677\u5165\u4e24\u96be\u5883\u5730\uff0c\u8fd9\u662f\u56e0\u4e3a\u4f20\u7edf\u836f\u7269\u6cbb\u7597\u4ec5\u80fd\u7f13\u89e3\u90e8\u5206\u75c7\u72b6[6],[7]\uff0c\u65e0\u6cd5\u5e72\u9884\u75be\u75c5\u75c5\u56e0\uff0c\u4e5f\u96be\u4ee5\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u3002\u800c\u4fb5\u5165\u5f0f\u6cbb\u7597\u5bf9\u4e13\u4e1a\u6280\u672f\u53ca\u7ecf\u9a8c\u8981\u6c42\u9ad8\uff0c\u53ef\u53ca\u6027\u8f83\u5dee\uff0c\u4e14\u666e\u904d\u5b58\u5728\u624b\u672f\u5e76\u53d1\u75c7[5]\uff0c\u518d\u5e72\u9884\u98ce\u9669\u8f83\u9ad8[9]\uff0c\u56e0\u6b64\u60a3\u8005\u666e\u904d\u63a5\u53d7\u5ea6\u8f83\u4f4e\u3002\u957f\u6b64\u4ee5\u5f80\uff0c\u4e0d\u4ec5\u5927\u5e45\u5f71\u54cd\u60a3\u8005\u7684\u9884\u540e\u548c\u751f\u6d3b\u8d28\u91cf\uff0c\u4e5f\u5e26\u6765\u4e86\u6c89\u91cd\u7684\u75be\u75c5\u548c\u7ecf\u6d4e\u8d1f\u62c5\u3002\u6b64\u6b21\u8fdb\u535a\u4f1a\u5c55\u51fa\u7684\u7b2c\u4e8c\u4ee3\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u963f\u592b\u51ef\u6cf0\u7247\uff0c\u5c06\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u5e0c\u671b\u3002”<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

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\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\n “
\n \u521b\u65b0\u9776\u70b9
\n “*
\n \uff1a\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u52a9\u529b\u964d\u4f4e\u9ad8\u7518\u6cb9\u4e09\u916f\u5f15\u53d1\u7684\u7cfb\u5217\u98ce\u9669\n <\/p>\n

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\n \u4e2d\u56fd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u8054\u76df\u526f\u4e3b\u5e2d\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u5185\u79d1\u5b66\uff08\u5fc3\u8840\u7ba1\u75c5\u5b66\uff09\u4e3b\u4efb\u533b\u5e08\u674e\u52c7\u6559\u6388\u6307\u51fa\uff1a”\u76ee\u524d\u5168\u7403\u5c1a\u65e0\u4e13\u95e8\u9488\u5bf9\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\u7684\u6709\u6548\u6cbb\u7597\u836f\u7269\uff0c\u800c\u73b0\u6709\u7597\u6cd5\u5bf9\u4e25\u91cd\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u7684\u6539\u5584\u4e5f\u8f83\u4e3a\u6709\u9650\u3002\u90e8\u5206\u4e00\u7ebf\u836f\u7269\u5728\u9ad8\u7518\u6cb9\u4e09\u916f\u4eba\u7fa4\u4e2d\uff0c\u7518\u6cb9\u4e09\u916f\u964d\u5e45\u4ec5\u7ef4\u6301\u572820%-50%[11]\uff0c\u5bf9\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\u60a3\u8005\u57fa\u672c\u65e0\u6548\u3002\u540c\u65f6\uff0c\u60a3\u8005\u8fd8\u8981\u4f9d\u9760\u4e25\u683c\u7684\u4f4e\u8102\u3001\u4f4e\u7cd6\u996e\u98df\u548c\u6bcf\u5468\u575a\u6301\u9ad8\u5f3a\u5ea6\u8fd0\u52a8\u6765\u63a7\u5236\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\uff0c\u5bfc\u81f4\u957f\u671f\u575a\u6301\u56f0\u96be\uff0c\u6548\u679c\u4e0d\u7a33\u5b9a\uff0c\u7ecf\u5e38\u7531\u4e8e\u4e0d\u660e\u539f\u56e0\u5bfc\u81f4\u7518\u6cb9\u4e09\u916f\u9aa4\u5347\u3002\u6b64\u6b21\u8fdb\u535a\u4f1a\u5168\u7403\u9996\u79c0\u7684\u521b\u65b0\u836f\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u5c31\u6709\u671b\u7834\u89e3\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\u5728\u4e2d\u56fd\u2018\u65e0\u836f\u53ef\u63a7’\u56f0\u5c40\uff0c\u5e76\u5f00\u542f\u4e25\u91cd\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u7684\u6cbb\u7597\u53d8\u9769\u3002”<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u662f\u5168\u7403\u9996\u4e2a\u4f5c\u7528\u4e8e\u521b\u65b0\u9776\u70b9APOC3 mRNA\u7684\u00a0siRNA\u7c7b\u836f\u7269\u3002\u5176\u5168\u74033\u671f\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u60a3\u8005\u4f7f\u75281\u4e2a\u6708\u5373\u89c2\u5bdf\u5230\u7a7a\u8179\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff0c\u6cbb\u759710\u4e2a\u6708\u7a7a\u8179\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u8f83\u57fa\u7ebf\u964d\u4f4e80%\uff0c12\u4e2a\u6708\u6025\u6027\u80f0\u817a\u708e\u53d1\u751f\u7387\u8f83\u5b89\u6170\u5242\u964d\u4f4e83%\uff0c\u4e14\u4e09\u4e2a\u6708\u7528\u836f\u4e00\u6b21\uff0c\u957f\u6548\u4fbf\u6377\uff0c\u6613\u4e8e\u60a3\u8005\u957f\u671f\u575a\u6301\u3002<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\n Oxana Monge\u8868\u793a\uff1a”\u8d5b\u8bfa\u83f2\u6df1\u8015\u4e2d\u56fd\u5fc3\u8840\u7ba1\u9886\u57df\u8fd1\u4e09\u5341\u5e74\uff0c\u901a\u8fc7\u591a\u5143\u521b\u65b0\u6a21\u5f0f\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u5e7f\u6cdb\u7684\u521b\u65b0\u6cbb\u7597\u65b9\u6848\uff0c\u5176\u4e2d\u591a\u79cd\u6cbb\u7597\u65b9\u6848\u5df2\u6210\u4e3a\u6ee1\u8db3\u5173\u952e\u9700\u6c42\u7684\u91d1\u6807\u51c6\u3002\u57fa\u4e8e\u6211\u4eec\u5728\u5fc3\u8840\u7ba1\u9886\u57df\u7684\u6df1\u539a\u79ef\u6dc0\u4ee5\u53ca\u4e0e\u4e0d\u540c\u533b\u7597\u884c\u4e1a\u4f19\u4f34\u7684\u7d27\u5bc6\u5408\u4f5c\u57fa\u7840\uff0c\u6211\u4eec\u4e0d\u65ad\u52a0\u901f\u521b\u65b0\u811a\u6b65\uff0c\u63a8\u52a8\u60a3\u8005\u53ef\u53ca\u3002\u4e0d\u6b62\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u8d5b\u8bfa\u83f2\u4e0e\u2018\u5065\u5eb7\u4e2d\u56fd’\u540c\u9891\u5171\u632f\uff0c\u805a\u7126\u5fc3\u8840\u7ba1\u3001\u7cd6\u5c3f\u75c5\u3001\u547c\u5438\u3001\u80bf\u7624\u56db\u5927\u6162\u75c5\u9886\u57df\uff0c\u8df5\u884c\u6211\u4eec\u5bf9\u5e7f\u5927\u4e2d\u56fd\u60a3\u8005\u59cb\u7ec8\u5982\u4e00\u7684\u627f\u8bfa\u3002”<\/p>\n

\u6b64\u5916\uff0c\u8d5b\u8bfa\u83f2\u5c55\u53f0\u4e0a\u4e00\u679a\u540d\u4e3a”\u7115\u53d1\u5fc3\u751f”\u7684\u5de8\u578b\u5fc3\u810f\u4e92\u52a8\u88c5\u7f6e\u540c\u6837\u5f15\u4eba\u6ce8\u76ee\uff0c\u901a\u8fc7\u4e0e\u53c2\u89c2\u8005\u7684\u4e92\u52a8\u5171\u540c\u5b8c\u6210\u6700\u7ec8\u7684\u5fc3\u810f\u827a\u672f\u4f5c\u54c1\uff0c\u878d\u5408\u81ea\u7136\u4e0e\u79d1\u5b66\u4e4b\u529b\u4e0e\u75be\u75c5\u6297\u4e89\uff0c\u7115\u53d1\u5fc3\u8840\u7ba1\u75be\u75c5\u60a3\u8005\u7684\u751f\u547d\u5149\u5f69\u3002<\/p>\n

\n

\n
\n [1]\u00a0\u8d75\u51ac,\u97e9\u96c5\u73b2.\u6211\u56fd\u5fc3\u8840\u7ba1\u75c5\u9884\u9632\u7b56\u7565\u53ca\u9762\u4e34\u7684\u6311\u6218[J].\u4e2d\u534e\u533b\u5b66\u4fe1\u606f\u5bfc\u62a5, 2024, 39(09):11-11.DOI:10.3760\/cma.j.issn.1000-8039.2024.09.125.<\/span>\n <\/p>\n

\n
\n [2]\u00a0\u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e13\u5bb6\u59d4\u5458\u4f1a\u5fc3\u529b\u8870\u7aed\u4e13\u4e1a\u59d4\u5458\u4f1a,\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u5fc3\u529b\u8870\u7aed\u4e13\u4e1a\u59d4\u5458\u4f1a,\u4e2d\u534e\u533b\u5b66\u4f1a\u5fc3\u8840\u7ba1\u5206\u4f1a\u5fc3\u529b\u8870\u7aed\u5b66\u7ec4,\u7b49. \u4e2d\u56fd\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u6307\u53572022[J]. \u4e2d\u534e\u5fc3\u529b\u8870\u7aed\u548c\u5fc3\u808c\u75c5\u6742\u5fd7,2022,06(2):80-105.<\/span>\n <\/p>\n

\n
\n [3]\u00a0\u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u5fc3\u808c\u75c5\u4e13\u79d1\u8054\u76df,\u4e2d\u56fd\u533b\u7597\u4fdd\u5065\u56fd\u9645\u4ea4\u6d41\u4fc3\u8fdb\u4f1a\u5fc3\u8840\u7ba1\u75c5\u7cbe\u51c6\u533b\u5b66\u5206\u4f1a,\u5b8b\u96f7,\u7b49. \u4e2d\u56fd\u5fc3\u808c\u75c5\u7efc\u5408\u7ba1\u7406\u6307\u53572025[J]. \u4e2d\u56fd\u5faa\u73af\u6742\u5fd7,2025,40(5):420-462.<\/span>\n <\/p>\n

\n
\n [4]\u00a0\u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u5fc3\u808c\u75c5\u4e13\u79d1\u8054\u76df,\u4e2d\u56fd\u533b\u7597\u4fdd\u5065\u56fd\u9645\u4ea4\u6d41\u4fc3\u8fdb\u4f1a\u5fc3\u8840\u7ba1\u75c5\u7cbe\u51c6\u533b\u5b66\u5206\u4f1a”\u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u53572023″\u4e13\u5bb6\u7ec4. \u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u53572023[J]. \u4e2d\u56fd\u5faa\u73af\u6742\u5fd7,2023,38(1):1-33.<\/span>\n <\/p>\n

\n
\n [5]\u00a0Maron MS, Olivotto I, Betocchi S, Casey SA, Lesser JR, Losi MA, Cecchi F, Maron BJ. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med. 2003 Jan 23;348(4):295-303.<\/span>\n <\/p>\n

\n
\n [6]\u00a0Ommen SR, Ho CY, Asif IM, et al. 2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines[J]. Circulation. 2024 Jun 4;149(23):e1239-e1311.<\/span>\n <\/p>\n

\n
\n [7]\u00a0\u4efb\u7b11\u96e8,\u7530\u5e84,\u5f20\u6292\u626c. \u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\u548c\u4e34\u5e8a\u5e94\u7528[J]. \u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7,2025,53(9):1083-1088.<\/span>\n <\/p>\n

\n
\n [8]\u00a0Maron, M.S., et al., Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy. N Engl J Med, 2024. 390(20): p. 1849-1861.<\/span>\n <\/p>\n

\n
\n [9]\u00a0Deng LH,et al. World J Gastroenterol, 2008;<\/span>\n <\/p>\n

\n
\n [10]\u00a0Sun D, et al . Adv Clin Med. 2018;8:318\u2013324<\/span>\n <\/p>\n

\n
\n [11]\u00a0J Clin Lipidol. 2025 Jul-Aug;19(4):723-736. doi: 10.1016\/j.jacl.2025.03.012. Epub 2025 Mar 28. 2. \u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\u7684\u7814\u7a76\u8fdb\u5c55<\/span>\n <\/p>\n<\/div>\n

\n *
\n \u8be5\u8d44\u6599\u53ca\u5185\u5bb9\u4ec5\u7528\u4e8e\u7b2c\u516b\u5c4a\u4e2d\u56fd\u56fd\u9645\u8fdb\u53e3\u535a\u89c8\u4f1a\uff08\u8fdb\u535a\u4f1a\uff09\u4fe1\u606f\u5206\u4eab\u3002\u5bf9\u4e8e\u5c1a\u672a\u5728\u4e2d\u56fd\u5927\u9646\u6ce8\u518c\u7684\u4ea7\u54c1\uff0c\u5176\u76f8\u5173\u4fe1\u606f\u4ec5\u4f9b\u8fdb\u535a\u4f1a\u5206\u4eab\u6216\u4ea4\u6d41\uff0c\u5728\u4efb\u4f55\u60c5\u51b5\u4e0b\u5747\u4e0d\u5e94\u88ab\u89c6\u4e3a\u5e7f\u544a\u6216\u5177\u6709\u63a8\u5e7f\u610f\u56fe\u3002
\n **\u963f\u592b\u51ef\u6cf0\u7247\u4e0e\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u4ea7\u54c1\u6548\u679c\u56fe\u4ec5\u4e3a\u793a\u610f\uff0c\u4e14\u4ec5\u9650\u4e2d\u56fd\u56fd\u9645\u8fdb\u53e3\u535a\u89c8\u4f1a\u5c55\u793a\u4e0e\u4f20\u64ad\u4f7f\u7528
\n ***\u963f\u592b\u51ef\u6cf0\u7247\u4e0e\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\n <\/p>\n

###<\/p>\n

\n \u5173\u4e8e\u8d5b\u8bfa\u83f2\u4e2d\u56fd\n <\/p>\n

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\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.sanofi.cn<\/a>\u00a0\uff0c\u6216\u5173\u6ce8”\u8d5b\u8bfa\u83f2\u4e2d\u56fd”\u5fae\u4fe1\u516c\u4f17\u53f7\u3002<\/p>\n

\n \u5173\u4e8e\u8d5b\u8bfa\u83f2\n <\/p>\n

\u8d5b\u8bfa\u83f2\u662f\u4e00\u5bb6\u7814\u53d1\u9a71\u52a8\u3001AI \u8d4b\u80fd\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u7115\u53d1\u751f\u547d\u5149\u5f69\u5e76\u5b9e\u73b0\u5f3a\u52b2\u589e\u957f\u3002\u51ed\u501f\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u6df1\u523b\u7406\u89e3\uff0c\u6211\u4eec\u7814\u53d1\u7684\u836f\u7269\u548c\u75ab\u82d7\u4e3a\u5168\u7403\u6570\u767e\u4e07\u6c11\u4f17\u63d0\u4f9b\u6cbb\u7597\u4e0e\u5b88\u62a4\uff0c\u6211\u4eec\u7684\u521b\u65b0\u7ba1\u7ebf\u6709\u671b\u60e0\u53ca\u66f4\u5e7f\u6cdb\u4eba\u7fa4\u3002\u6211\u4eec\u79c9\u6301\u5171\u540c\u7684\u4f7f\u547d\uff1a\u8ffd\u6c42\u79d1\u5b66\u5947\u8ff9\uff0c\u7115\u53d1\u751f\u547d\u5149\u5f69\uff1b\u5b83\u6fc0\u52b1\u6211\u4eec\u9510\u610f\u8fdb\u53d6\uff0c\u5168\u529b\u5e94\u5bf9\u5f53\u4eca\u65f6\u4ee3\u6700\u7d27\u8feb\u7684\u533b\u7597\u3001\u73af\u5883\u548c\u793e\u4f1a\u6311\u6218\uff0c\u4e3a\u6211\u4eec\u6240\u670d\u52a1\u7684\u4eba\u548c\u793e\u533a\u5e26\u6765\u79ef\u6781\u5f71\u54cd\u3002<\/p>\n

\u8d5b\u8bfa\u83f2\u524d\u77bb\u6027\u58f0\u660e<\/p>\n

\n \u672c\u65b0\u95fb\u7a3f\u5305\u542b
\n 1995
\n \u5e74\u4fee\u8ba2\u7684\u300a\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\u3002\u524d\u77bb\u6027\u58f0\u660e\u5e76\u975e\u5bf9\u5386\u53f2\u4e8b\u5b9e\u7684\u9648\u8ff0\u3002\u8fd9\u4e9b\u58f0\u660e\u5305\u62ec
\n \u8fd9\u4e9b\u58f0\u660e\u5305\u62ec\u9884\u6d4b\u548c\u4f30\u8ba1\u4ee5\u53ca\u5176\u57fa\u7840\u5047\u8bbe\uff0c\u6d89\u53ca\u672a\u6765\u8d22\u52a1\u7ed3\u679c\u3001\u4e8b\u4ef6\u3001\u8fd0\u8425\u3001\u670d\u52a1\u3001\u4ea7\u54c1\u5f00\u53d1\u548c\u6f5c\u529b\u7684\u8ba1\u5212\u3001\u76ee\u6807\u3001\u610f\u56fe\u548c\u671f\u671b\u7684\u9648\u8ff0\uff0c\u4ee5\u53ca\u4e0e\u672a\u6765\u4e1a\u7ee9\u76f8\u5173\u7684\u9648\u8ff0\u3002
\n \u901a\u5e38\u53ef\u4ee5\u5229\u7528\u8bf8\u5982”\u671f\u671b”\u3001”\u9884\u671f”\u3001”\u76f8\u4fe1”\u3001”\u6253\u7b97”\u3001”\u4f30\u8ba1”\u3001”\u8ba1\u5212”\u7b49\u8bcd\u8bed\uff0c\u4ee5\u53ca\u7c7b\u4f3c\u8868\u8fbe\u4f5c\u4e3a\u5224\u5b9a\u524d\u77bb\u6027\u58f0\u660e\u7684\u4f9d\u636e\u3002\u5c3d\u7ba1\u8d5b\u8bfa\u83f2\u7ba1\u7406\u5c42\u8ba4\u4e3a\u8be5\u7bc7\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u6240\u53cd\u6620\u7684\u9884\u671f\u5177\u6709\u5408\u7406\u6027\uff0c\u6295\u8d44\u8005\u4ecd\u9700\u6ce8\u610f\u8fd9\u4e9b\u524d\u77bb\u6027\u4fe1\u606f\u548c\u58f0\u660e\u53d7\u5236\u4e8e\u8bf8\u591a\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u56e0\u7d20\uff0c\u5176\u4e2d\u8bb8\u591a\u96be\u4ee5\u9884\u6d4b\u4e14\u901a\u5e38\u4e0d\u88ab\u8d5b\u8bfa\u83f2\u6240\u63a7\u5236\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u5b9e\u9645\u7ed3\u679c\u548c\u53d1\u5c55\u4e0e\u524d\u77bb\u6027\u4fe1\u606f\u548c\u9648\u8ff0\u4e2d\u6240\u8868\u8fbe\u3001\u6697\u793a\u6216\u9884\u6d4b\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u7814\u7a76\u548c\u5f00\u53d1\u4e2d\u56fa\u6709\u7684\u4e0d\u786e\u5b9a\u56e0\u7d20\uff0c\u672a\u6765\u7684\u4e34\u5e8a\u6570\u636e\u548c\u5206\u6790\uff0c\u5305\u62ec\u4ea7\u54c1\u4e0a\u5e02\u540e\u6240\u83b7\u53d6\u7684\u6570\u636e\u548c\u6240\u8fdb\u884c\u7684\u5206\u6790\uff0c
\n \u7f8e\u56fd\u98df\u54c1\u548c\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08
\n FDA
\n \uff09\u6216\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08
\n EMA
\n \uff09\u7b49\u76d1\u7ba1\u673a\u6784\u5bf9\u4efb\u4f55\u836f\u7269\u3001\u5668\u68b0\u6216\u751f\u7269\u5236\u54c1\u7533\u8bf7\u662f\u5426\u4ee5\u53ca\u4f55\u65f6\u6279\u51c6\u7684\u51b3\u5b9a\uff0c\u4ee5\u53ca\u5bf9\u6807\u7b7e\u548c\u5176\u4ed6\u53ef\u80fd\u5f71\u54cd\u8be5\u7c7b\u5019\u9009\u4ea7\u54c1\u53ef\u5f97\u6027\u6216\u5546\u4e1a\u6f5c\u529b\u7684\u4e8b\u9879\u7684\u51b3\u5b9a\uff0c\u6279\u51c6\u7684\u5019\u9009\u4ea7\u54c1\u53ef\u80fd\u5546\u4e1a\u4e0a\u4e0d\u6210\u529f\u7684\u4e8b\u5b9e\uff0c\u66ff\u4ee3\u6027\u7597\u6cd5\u7684\u672a\u6765\u6279\u51c6\u548c\u5546\u4e1a\u6210\u529f\uff0c\u8d5b\u8bfa\u83f2\u4ece\u5916\u90e8\u589e\u957f\u673a\u4f1a\u4e2d\u53d7\u76ca\uff0c\u5b8c\u6210\u76f8\u5173\u4ea4\u6613\u548c
\n \/
\n \u6216\u83b7\u5f97\u76d1\u7ba1\u6279\u51c6\u7684\u80fd\u529b\uff0c\u7eed
\n \u4e0e\u77e5\u8bc6\u4ea7\u6743\u76f8\u5173\u7684\u5f85\u51b3\u6216\u672a\u6765\u8bc9\u8bbc\u548c\u8fd9\u79cd\u8bc9\u8bbc\u7684\u6700\u7ec8\u7ed3\u679c\u6709\u5173\u7684\u98ce\u9669\uff0c
\n \u6c47\u7387\u548c\u5229\u7387\u7684\u8d8b\u52bf\uff0c
\n \u4ee5\u53ca\u6ce2\u52a8\u7684\u7ecf\u6d4e\u548c\u5e02\u573a\u6761\u4ef6\uff0c
\n \u6210\u672c\u63a7\u5236\u63aa\u65bd\u53ca\u5176\u540e\u7eed\u53d8\u5316\uff0c\u4ee5\u53ca\u6d41\u884c\u75c5\u6216\u5176\u4ed6\u5168\u7403\u5371\u673a\u53ef\u80fd
\n \u7ed9\u6211\u4eec\u3001\u5ba2\u6237\u3001\u4f9b\u5e94\u5546\u548c\u5176\u4ed6\u4e1a\u52a1\u5408\u4f5c\u4f19\u4f34\u4ee5\u53ca\u4efb\u4f55\u4e00\u65b9\u7684\u8d22\u52a1\u72b6\u51b5\u5e26\u6765\u7684\u5f71\u54cd\uff0c\u4e5f\u5305\u62ec\u5bf9\u6211\u4eec\u7684\u5458\u5de5\u548c\u5168\u7403\u7ecf\u6d4e\u5e26\u6765\u7684\u5f71\u54cd\u3002\u8fd9\u4e9b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u4e5f\u5305\u62ec\u8d5b\u8bfa\u83f2\u5728\u516c\u5f00\u5448\u62a5\u7ed9\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\uff08
\n SEC
\n \uff09\u548c\u6cd5\u56fd\u91d1\u878d\u5e02\u573a\u7ba1\u7406\u5c40\uff08
\n AMF
\n \uff09\u7684\u62a5\u544a\u4e2d\u5df2\u4f5c\u8ba8\u8bba\u6216\u660e\u786e\u7684\u90e8\u5206\uff0c\u5176\u4e2d\u5305\u62ec\u5217\u4e8e\u8868
\n 20-F
\n \u7684\u8d5b\u8bfa\u83f2\u5e74\u5ea6\u62a5\u544a\uff08\u622a\u6b62\u65e5\u671f
\n 2024
\n \u5e74
\n 12
\n \u6708
\n 31
\n \u65e5\uff09\u4e2d\u7684”\u98ce\u9669\u56e0\u7d20”\u548c”\u524d\u77bb\u6027\u58f0\u660e
\n \u8b66\u793a”\u3002\u9664\u975e\u5b58\u5728\u53ef\u9002\u7528\u7684\u6cd5\u5f8b\u89c4\u5b9a\uff0c\u8d5b\u8bfa\u83f2\u4e0d\u627f\u62c5\u66f4\u65b0\u548c\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u4fe1\u606f\u548c\u9648\u8ff0\u7684\u4e49\u52a1\u3002\u00a0<\/p>\n

<\/div>\n

SOURCE \u8d5b\u8bfa\u83f2\u4e2d\u56fd<\/p>","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d77 2025\u5e7411\u67087\u65e5 \/\u7f8e\u901a\u793e\/ — \u7b2c\u516b\u5c4a\u4e2d\u56fd\u56fd\u9645\u8fdb\u53e3\u535a\u89c8\u4f1a\uff08\u4ee5\u4e0b\u7b80\u79f0”\u8fdb\u535a\u4f1a”\uff09\u671f\u95f4\uff0c\u8d5b\u8bfa\u83f2\u8fdb\u535a\u4f1a\u5f00\u9986\u4eea\u5f0f\u66a8\u5fc3\u8840\u7ba1\u9886\u57df\u521b\u65b0\u5168\u7403\u9996\u79c0\u4eea\u5f0f\u6b63\u5f0f\u4e3e\u884c\u3002\u8fde\u7eed\u516b\u5e74\u5168\u52e4\u53c2\u5c55\u8fdb\u535a\u4f1a\u7684\u8d5b\u8bfa\u83f2\u6b64\u6b21\u5e26\u6765\u4e86\u5fc3\u8840\u7ba1\u9886\u57df\u4e24\u5927\u521b\u65b0\u836f\u2014\u2014\u963f\u592b\u51ef\u6cf0\u7247\u548c\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7684\u5168\u7403\u9996\u79c0\u3002 \u8d5b\u8bfa\u83f2\u666e\u836f\u4e2d\u56fd\u533a\u603b\u7ecf\u7406 Oxana 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[…]<\/p>\n","protected":false},"author":0,"featured_media":18127,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-18126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u4e24\u5927\u5fc3\u8840\u7ba1\u521b\u65b0\u836f\u5168\u7403\u9996\u79c0 "\u8fdb\u535a\u5168\u52e4\u751f"\u8d5b\u8bfa\u83f2\u521b\u65b0\u518d\u51fa\u5708 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u4e24\u5927\u5fc3\u8840\u7ba1\u521b\u65b0\u836f\u5168\u7403\u9996\u79c0-\u8fdb\u535a\u5168\u52e4\u751f\u8d5b\u8bfa\u83f2\u521b\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e24\u5927\u5fc3\u8840\u7ba1\u521b\u65b0\u836f\u5168\u7403\u9996\u79c0 "\u8fdb\u535a\u5168\u52e4\u751f"\u8d5b\u8bfa\u83f2\u521b\u65b0\u518d\u51fa\u5708 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d77 2025\u5e7411\u67087\u65e5 \/\u7f8e\u901a\u793e\/ — \u7b2c\u516b\u5c4a\u4e2d\u56fd\u56fd\u9645\u8fdb\u53e3\u535a\u89c8\u4f1a\uff08\u4ee5\u4e0b\u7b80\u79f0”\u8fdb\u535a\u4f1a”\uff09\u671f\u95f4\uff0c\u8d5b\u8bfa\u83f2\u8fdb\u535a\u4f1a\u5f00\u9986\u4eea\u5f0f\u66a8\u5fc3\u8840\u7ba1\u9886\u57df\u521b\u65b0\u5168\u7403\u9996\u79c0\u4eea\u5f0f\u6b63\u5f0f\u4e3e\u884c\u3002\u8fde\u7eed\u516b\u5e74\u5168\u52e4\u53c2\u5c55\u8fdb\u535a\u4f1a\u7684\u8d5b\u8bfa\u83f2\u6b64\u6b21\u5e26\u6765\u4e86\u5fc3\u8840\u7ba1\u9886\u57df\u4e24\u5927\u521b\u65b0\u836f\u2014\u2014\u963f\u592b\u51ef\u6cf0\u7247\u548c\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7684\u5168\u7403\u9996\u79c0\u3002 \u8d5b\u8bfa\u83f2\u666e\u836f\u4e2d\u56fd\u533a\u603b\u7ecf\u7406 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