<\/a><\/p>\n \n <\/p>\n<\/div>\n
ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u5728\u6b64\u6b21\u4f1a\u8bae\u4e0a\uff0c\u4e9a\u76db\u533b\u836f\u7684\u591a\u4e2a\u521b\u65b0\u6210\u679c\u518d\u5ea6\u83b7\u5f97\u56fd\u9645\u5b66\u672f\u754c\u7684\u5173\u6ce8\uff0c\u00a0\u4e09\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e00\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002<\/p>\n
\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u7814\u7a76\u6570\u636e\u8868\u660e\uff0c\u5229\u751f\u59a5\u00ae\u5355\u836f\u5728\u5bf9BTKi\u8010\u836f\u7684\u91cd\u5ea6\u7ecf\u6cbbR\/R CLL\/SLL\u60a3\u8005\u4e2d\u5c55\u73b0\u4e86\u663e\u8457\u4e14\u6301\u4e45\u7684\u7597\u6548\uff0c\u4e14\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08TLS\uff09\u75c5\u4f8b\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u7814\u7a76\u5171\u5165\u7ec477\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d33\u4f8b\uff0842.9%\uff09\u4f34\u67d3\u8272\u4f53\u590d\u6742\u6838\u578b\uff0c30\u4f8b\uff0839%\uff09\u643a\u5e26del(17p)\/TP53\u7a81\u53d8\uff0c41\u4f8b\uff0853.2%\uff09\u4e3a\u672a\u7a81\u53d8IGHV\u3002\u8fd9\u4e9b\u9ad8\u5371\u56e0\u7d20\u7684\u6bd4\u4f8b\u8fdc\u8fdc\u9ad8\u4e8e\u65e2\u5f80\u540c\u7c7b\u578b\u7814\u7a76\uff0c\u5c24\u5176\u5728\u643a\u5e26\u590d\u6742\u6838\u578b\u7684\u60a3\u8005\u4e2d\uff0c63.6%\u7684\u60a3\u8005\u8fd8\u540c\u65f6\u5408\u5e76del(17p)\/TP53\u7a81\u53d8\uff0c\u4e1463.6%\u7684\u60a3\u8005\u4e3a\u9ad8\u5ea6\u590d\u6742\u6838\u578b\uff08>=5\u4e2a\u67d3\u8272\u4f53\u5f02\u5e38\uff09\u3002\u800c\u5229\u751f\u59a5\u00ae\u5728\u5168\u90e8\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe62.5%\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u6cbb\u7597\u4f18\u52bf\u3002<\/p>\n
\u5229\u751f\u59a5\u00ae\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u53e3\u670dBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u901a\u8fc7\u9009\u62e9\u6027\u6291\u5236Bcl-2\u86cb\u767d\uff0c\u6062\u590d\u764c\u7ec6\u80de\u7684\u6b63\u5e38\u51cb\u4ea1\u8fc7\u7a0b\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002\u76ee\u524d\uff0c\u8be5\u836f\u7269\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u7ecf\u8fc7\u81f3\u5c11\u5305\u542bBTKi\u5728\u5185\u7684\u4e00\u79cd\u7cfb\u7edf\u6cbb\u7597\u7684\u6210\u4ebaCLL\/SLL\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9a\u76db\u533b\u836f\u6b63\u5728\u5f00\u5c55\u8be5\u836f\u7269\u56db\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u548c\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u51e0\u5927\u9002\u5e94\u75c7\u3002<\/p>\n
\u6b64\u9879\u7814\u7a76\u7684\u62a5\u544a\u4eba\uff0c\u90d1\u5dde\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u3001\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662\u5468\u53ef\u6811\u6559\u6388\u8868\u793a\uff1a\u00a0“\u968f\u7740\u6cbb\u7597\u624b\u6bb5\u7684\u8fdb\u6b65\uff0c\u5982del(17p)\/TP53\u7a81\u53d8\u7b49\u90e8\u5206\u4f20\u7edf\u9ad8\u5371\u56e0\u7d20\u5df2\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u5f97\u4ee5\u5e94\u5bf9\uff0c\u7136\u800c\uff0c\u5982\u540c\u65f6\u518d\u5408\u5e76\u590d\u6742\u6838\u578b\u6216\u8005\u5b58\u5728\u9ad8\u5ea6\u590d\u6742\u6838\u578b\u8fd9\u4e9b\u975e\u5e38\u9ad8\u5371\u7684\u56e0\u7d20\uff0c\u76ee\u524d\u5df2\u6210\u4e3aCLL\/SLL\u60a3\u8005\u6700\u4e25\u5cfb\u7684\u6cbb\u7597\u56f0\u5883\u4e0e\u9884\u540e\u4e0d\u826f\u56e0\u7d20\uff0c\u4e34\u5e8a\u4e9f\u9700\u80fd\u6709\u6548\u5e94\u5bf9\u6b64\u7c7b\u60a3\u8005\u7684\u7a81\u7834\u6027\u6cbb\u7597\u65b9\u6848\u3002\u672c\u7814\u7a76\u5165\u7ec4\u4e86\u8fd1\u534a\u6570\u643a\u5e26\u590d\u6742\u6838\u578b\u7684\u60a3\u8005\uff0c\u4e14\u8fd9\u4e9b\u9ad8\u5371\u60a3\u8005\u4e2d\u8fd12\/3\u8fd8\u540c\u65f6\u5408\u5e76del(17p)\/TP53\u7a81\u53d8\uff0c\u6216\u8005\u4e3a\u9ad8\u5ea6\u590d\u6742\u6838\u578b\uff0c\u662f\u4e00\u7c7b\u6781\u9ad8\u5371\u3001\u9884\u540e\u975e\u5e38\u4e0d\u597d\u7684\u4eba\u7fa4\u3002\u603b\u4f53\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5229\u751f\u59a5\u00ae\u5355\u836f\u5728\u91cd\u5ea6\u7ecf\u6cbb\u3001\u65e2\u5f80\u591a\u7ebf\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5c24\u5176\u662f\u5177\u6709\u590d\u6742\u6838\u578b\u7b49\u6781\u9ad8\u5371\u56e0\u7d20\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73b0\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u6df1\u5ea6\u548c\u6301\u4e45\u7f13\u89e3\uff0c\u5e76\u4e14\u5177\u6709\u2018\u9ad8\u6548\u3001\u4fbf\u6377\u3001\u5b89\u5168’\u7684\u7279\u6027\u3002\u8fd9\u4e3a\u6211\u4eec\u653b\u514b\u8fd9\u4e00\u4e34\u5e8a\u96be\u70b9\u63d0\u4f9b\u4e86\u65b0\u7684\u5f3a\u6709\u529b\u7684\u6b66\u5668\uff0c\u4e5f\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002”<\/p>\n
\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u00a0“\u6211\u4eec\u975e\u5e38\u81ea\u8c6a\u5229\u751f\u59a5\u00ae\u7684\u8fd9\u9879\u6ce8\u518c\u7814\u7a76\u6570\u636e\u80fd\u5728ASH\u8fd9\u4e00\u56fd\u9645\u9876\u7ea7\u8840\u6db2\u5b66\u76db\u4f1a\u4e0a\u8fdb\u884c\u53e3\u5934\u62a5\u544a\u3002\u8be5\u7814\u7a76\u6210\u679c\u4e0d\u4ec5\u652f\u6301\u4e86\u5229\u751f\u59a5\u00ae\u5728\u4e2d\u56fd\u6210\u529f\u83b7\u6279\u4e0a\u5e02\uff0c\u5176\u663e\u793a\u7684\u5229\u751f\u59a5\u00ae\u5728\u7597\u6548\u548c\u5b89\u5168\u6027\u65b9\u9762\u7684\u663e\u8457\u5dee\u5f02\u5316\u4f18\u52bf\u8fd8\u6709\u671b\u89e3\u51b3\u5168\u7403CLL\/SLL\u6cbb\u7597\u9886\u57df\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002”<\/p>\n
\u6b64\u9879\u7814\u7a76\u57282025 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n
Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton’s tyrosine kinase inhibitors (BTKis)<\/p>\n
\u5229\u6c99\u6258\u514b\u62c9\u5355\u836f\u6cbb\u7597\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08BTKi\uff09\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518c\u6027II\u671f\u7814\u7a76\u7ed3\u679c<\/p>\n
\u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a
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\u62a5\u544a\u65f6\u95f4\uff1a
2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4\uff09
2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u65f6\u95f4\uff09
\u7b2c\u4e00\u4f5c\u8005\uff1a\u90d1\u5dde\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u3001\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662 \u5468\u53ef\u6811\u6559\u6388
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\u6838\u5fc3\u8981\u70b9\uff1a<\/p>\n
\u7814\u7a76\u80cc\u666f\uff1a<\/p>\n
Bcl-2 \u6291\u5236\u5242\u5728\u6cbb\u7597CLL\/SLL\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5c3d\u7ba12016\u5e74\u7ef4\u5948\u514b\u62c9\u5355\u836f\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u00a017p\u00a0\u7f3a\u5931\u00a0[del(17p)] \u7684\u00a0CLL\/SLL \u60a3\u80051\uff0c\u4f46\u5bf9\u4e8e\u63a5\u53d7\u8fc7\u00a0BTKi\u6cbb\u7597\u5931\u8d25\u7684CLL\/SLL\u60a3\u8005\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u66fe\u63a5\u53d7\u8fc7\u57fa\u4e8e\u6297CD20\u5355\u6297\u7684\u514d\u75ab\u5316\u7597\uff08ICT\uff09\u6216\u5177\u6709\u9ad8\u5371\uff08HR\uff09\u56e0\u7d20\u7684\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u5b58\u5728\u7740\u8f83\u5927\u7684\u4ecd\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n
\u7814\u7a76\u4ecb\u7ecd\uff1a<\/p>\n
\u8be5\u7814\u7a76\uff08NCT05147467\uff09\u662f\u4e00\u9879\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7684\u5173\u952e\u6ce8\u518cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3002\u5165\u7ec4\u60a3\u8005\u4e3aBTK\u6291\u5236\u5242\u548c\u514d\u75ab\u5316\u7597\u5747\u96be\u6cbb\u3001\u590d\u53d1\u6216\u4e0d\u8010\u53d7\uff1b\u6216\u4e00\u7ebf\u4f7f\u7528BTK\u6291\u5236\u5242\u6cbb\u7597\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u514d\u75ab\u5316\u7597\u7684\u60a3\u8005\u3002<\/p>\n
\u57fa\u7ebf\u60a3\u8005\uff1a<\/p>\n
\u8be5\u7814\u7a76\u5171\u5165\u7ec477\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d33\u4f8b\uff0842.9%\uff09\u4f34\u67d3\u8272\u4f53\u590d\u6742\u6838\u578b\uff0c30\u4f8b\uff0839%\uff09\u643a\u5e26del(17p)\/TP53\u7a81\u53d8\uff0c41\u4f8b\uff0853.2%\uff09\u4e3a\u672a\u7a81\u53d8IGHV\u3002\u5728\u643a\u5e26\u590d\u6742\u6838\u578b\u7684\u60a3\u8005\u4e2d\uff0c63.6%\u7684\u60a3\u8005\u8fd8\u540c\u65f6\u5408\u5e76del(17p)\/TP53\u7a81\u53d8\u6216\u800563.6%\u7684\u60a3\u8005\u4e3a\u9ad8\u5ea6\u590d\u6742\u6838\u578b\uff08>=5\u4e2a\u67d3\u8272\u4f53\u5f02\u5e38\uff09\u3002<\/p>\n
\u7597\u6548\u6570\u636e\uff1a\u622a\u81f32025\u5e747\u670825\u65e5\uff0c\u572872\u4f8b\u53ef\u8bc4\u4f30R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u7ecf\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\u786e\u8ba4\u7684ORR\u4e3a62.5%\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a23.89\u4e2a\u6708\uff08\u4e2d\u4f4d\u968f\u8bbf22.01\u4e2a\u6708\uff09\u3002\u5728\u9ad8\u5371\u60a3\u8005\u7fa4\u4f53\uff08\u643a\u5e26\u5982del(17p)\/TP53\u7a81\u53d8\u3001\u590d\u6742\u6838\u578b\u3001IGHV\u672a\u7a81\u53d8\u7b49\u4e0d\u826f\u9884\u540e\u56e0\u7d20\uff09\u4e2d\uff0c\u6cbb\u7597\u663e\u793a\u51fa\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u6df1\u5ea6\u7f13\u89e3\u300221.8%\u8fbe\u5230\u5916\u5468\u8840\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027\u3002\u572811\u4f8b\u53ef\u8bc4\u4f30\u9aa8\u9ad3MRD\u7684\u60a3\u8005\u4e2d\uff0c54.5%\u8fbe\u5230\u9aa8\u9ad3MRD\u9634\u6027\u3002<\/p>\n
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\u53c2\u8003\u6587\u732e\uff1a<\/p>\n
1.\u00a0\u00a0\u00a0\u00a0\u00a0 Davids MS. Targeting BCL-2 in B-cell lymphomas. Blood. 2017 Aug 31;130(9):1081-1088. doi: 10.1182\/blood-2017-04-737338.<\/p>\n
\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/p>\n
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\u6b64\u9879\u7814\u7a76\u57282025 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton’s tyrosine kinase inhibitors (BTKis) \u5229\u6c99\u6258\u514b\u62c9\u5355\u836f\u6cbb\u7597\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08BTKi\uff09\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518c\u6027II\u671f\u7814\u7a76\u7ed3\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a\u6458\u8981\u7f16\u53f7\uff1a88\u5206\u4f1a\u573a\uff1a642. 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