<\/a><\/p>\n \n <\/p>\n<\/div>\n
\u9ed8\u514b\u533b\u836f\u5065\u5eb7\u9996\u5e2d\u6267\u884c\u5b98\u3001\u9ed8\u514b\u6267\u884c\u8463\u4e8b\u4f1a\u6210\u5458\u4e39\u5353\u822a\u8868\u793a\uff1a”\u968f\u7740\u8d1d\u6377\u8fc8\u00ae\u5728\u5168\u7403\u7684\u9996\u4e2a\u6ce8\u518c\u83b7\u6279\uff0c\u6211\u4eec\u6b63\u6301\u7eed\u8df5\u884c\u6539\u5584\u7f55\u89c1\u80bf\u7624\u60a3\u8005\u751f\u6d3b\u7684\u627f\u8bfa\u3002\u6b64\u6b21\u83b7\u6279\u66f4\u662f\u8fdb\u4e00\u6b65\u592f\u5b9e\u6211\u4eec\u5728\u7f55\u89c1\u80bf\u7624\u9886\u5bfc\u5730\u4f4d\u7684\u5173\u952e\u4e00\u6b65\u3002\u6211\u4eec\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u65e2\u80fd\u6539\u53d8\u75be\u75c5\u8fdb\u7a0b\u3001\u53c8\u53ef\u7f13\u89e3\u65e5\u5e38\u75c7\u72b6\u7684\u5e0c\u671b\u3002\u6211\u4eec\u6b63\u5728\u52a0\u901f\u63a8\u8fdb\u8d1d\u6377\u8fc8\u00ae\u65e9\u65e5\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005\uff0c\u5e76\u6301\u7eed\u63a8\u8fdb\u5176\u5728\u5168\u7403\u5176\u4ed6\u5e02\u573a\u7684\u6ce8\u518c\u5e03\u5c40\u3002”<\/p>\n
TGCT\uff0c\u65e2\u5f80\u53c8\u79f0\u8272\u7d20\u6c89\u7740\u7ed2\u6bdb\u7ed3\u8282\u6027\u6ed1\u819c\u708e\uff08PVNS\uff09\uff0c\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u5c40\u90e8\u4fb5\u88ad\u6027\u80bf\u7624\uff0c\u53ef\u5bfc\u81f4\u53d7\u7d2f\u5173\u8282\u51fa\u73b0\u8fdb\u884c\u6027\u52a0\u91cd\u7684\u80bf\u80c0\u3001\u50f5\u786c\u53ca\u6d3b\u52a8\u529f\u80fd\u53d7\u9650\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u6d3b\u52a8\u80fd\u529b\u548c\u751f\u6d3b\u8d28\u91cf\u3002\u82e5\u4e0d\u8fdb\u884c\u6cbb\u7597\u6216\u75c5\u60c5\u590d\u53d1\uff0c\u53ef\u80fd\u5bf9\u9aa8\u9abc\u3001\u5173\u8282\u53ca\u5468\u56f4\u7ec4\u7ec7\u9020\u6210\u4e0d\u53ef\u9006\u635f\u4f24\u3002<\/p>\n
\u8d1d\u6377\u8fc8\u00ae\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671fMANEUVER\u7684\u7814\u7a76\u7ed3\u679c\u3002\u6570\u636e\u663e\u793a\uff0c\u5728\u9488\u5bf9TGCT\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5c55\u73b0\u4e86\u57fa\u4e8eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\u7684\u6700\u9ad8\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u5e76\u4f34\u968f\u4e34\u5e8a\u7ed3\u5c40\u7684\u663e\u8457\u6539\u5584\u3002\u5728\u7b2c25\u5468\u65f6\uff0c\u57fa\u4e8eRECIST v1.1\u6807\u51c6\uff0c\u7ecf\u76f2\u6001\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BIRC\uff09\u8bc4\u4f30\u7684\u4e3b\u8981\u7ec8\u70b9\u7ed3\u679c\u663e\u793a\uff0c\u8d1d\u6377\u8fc8\u00ae\u7684ORR\u76f8\u8f83\u5b89\u6170\u5242\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u4e34\u5e8a\u6539\u5584\uff0854.0% vs. 3.2%\uff1bp<0.0001\uff09\u3002\u540c\u65f6\uff0c\u591a\u4e2a\u4e0e\u60a3\u8005\u65e5\u5e38\u751f\u6d3b\u529f\u80fd\u5bc6\u5207\u76f8\u5173\u7684\u6b21\u8981\u7ec8\u70b9\u4ea6\u663e\u793a\u51fa\u517c\u5177\u4e34\u5e8a\u610f\u4e49\u4e0e\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u6539\u5584\uff0c\u5305\u62ec\u76f8\u5bf9\u5173\u8282\u6d3b\u52a8\u8303\u56f4\u7684\u63d0\u5347\uff08p=0.0003\uff09\u3001\u8eab\u4f53\u529f\u80fd\u7684\u6539\u5584\uff08\u57fa\u4e8e\u8eab\u4f53\u529f\u80fd\u91cf\u8868PROMIS-PF\u8bc4\u4f30\uff0cp=0.0074\uff09\uff0c\u4ee5\u53ca\u6700\u4e25\u91cd\u50f5\u786c\uff08p<0.0001\uff09\u548c\u6700\u4e25\u91cd\u75bc\u75db\uff08p<0.0001\uff09\u7684\u663e\u8457\u51cf\u8f7b\u3002\u4e0a\u8ff0\u7ed3\u679c\u5df2\u57282025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002\u6b64\u5916\uff0c2025\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u516c\u5e03\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u663e\u793a\uff1a\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f414.3\u4e2a\u6708\u65f6\uff0c\u4f9d\u636eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\uff0c\u81ea\u7814\u7a76\u8d77\u59cb\u5373\u63a5\u53d7 \u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u60a3\u8005\u7684ORR\u6301\u7eed\u63d0\u5347\u81f376.2%\uff0895% CI: 63.8, 86.0\uff09\u3002<\/p>\n
\u5317\u4eac\u79ef\u6c34\u6f6d\u533b\u9662\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u7597\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u725b\u6653\u8f89\u6559\u6388\u8868\u793a\uff1a”\u5728\u4e2d\u56fd\uff0c\u5f88\u591aTGCT\u60a3\u8005\u957f\u671f\u9762\u4e34\u7740\u6cbb\u7597\u56f0\u5883 \u2014\u2014 \u9664\u624b\u672f\u5916\uff0c\u7f3a\u4e4f\u5176\u4ed6\u7684\u6cbb\u7597\u9009\u62e9\u3002\u800c\u5bf9\u4e8e\u80bf\u7624\u590d\u53d1\u6216\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u60a3\u8005\uff0c\u624b\u672f\u6cbb\u7597\u4e5f\u96be\u4ee5\u6ee1\u8db3\u5176\u9700\u6c42\u3002\u57fa\u4e8e\u5168\u7403MANEUVER\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u8d1d\u6377\u8fc8\u00ae\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u8fd9\u610f\u5473\u7740\u4e34\u5e8a\u533b\u751f\u6709\u673a\u4f1a\u4e3a\u60a3\u8005\u63d0\u4f9b\u7597\u6548\u786e\u5207\u4e14\u8010\u53d7\u6027\u826f\u597d\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u65b9\u6848\uff0c\u4e3a\u8fd9\u4e00\u96be\u6cbb\u6027\u75be\u75c5\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u4e9f\u9700\u7684\u7a81\u7834\u6027\u8fdb\u5c55\u3002”<\/p>\n
\u5728MANEUVER\u7814\u7a76\u4e2d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u80c6\u6c41\u6de4\u79ef\u6027\u809d\u6bd2\u6027\u6216\u6bdb\u53d1\u53ca\u76ae\u80a4\u8272\u7d20\u51cf\u9000\u7684\u8ff9\u8c61\u3002\u5728\u8be5\u8bd5\u9a8c\u7684\u968f\u673a\u3001\u53cc\u76f2\u6cbb\u7597\u9636\u6bb5\uff0c\u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u7ec4\u4e2d\uff0c\u56e0\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u505c\u836f\u7684\u60c5\u51b5\u89c1\u4e8e1\u4f8b\uff081.6%\uff09\u60a3\u8005\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u51cf\u91cf\u7684\u6bd4\u4f8b\u4e3a7.9%\uff08n=5\uff09\u3002<\/p>\n
\u853b\u5fb7\u7f55\u89c1\u75c5\u4e2d\u5fc3\u521b\u59cb\u4eba\u3001\u4e3b\u4efb\uff0c\u745e\u9e25\u516c\u76ca\u57fa\u91d1\u4f1a\u521b\u59cb\u4eba\u3001\u79d8\u4e66\u957f\u9ec4\u5982\u65b9\u5148\u751f\u8868\u793a\uff1a”TGCT\u5f15\u53d1\u7684\u75bc\u75db\u4e0e\u6d3b\u52a8\u53d7\u9650\uff0c\u4f1a\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\uff0c\u7ed9\u4ed6\u4eec\u5e26\u6765\u4e86\u5de8\u5927\u7684\u7cbe\u795e\u538b\u529b\u3002\u968f\u7740\u8d1d\u6377\u8fc8\u00ae\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u8fd9\u4e00\u7c7b\u7cfb\u7edf\u6027\u6cbb\u7597\u65b9\u6848\u80fd\u591f\u6709\u6548\u63a7\u5236\u80bf\u7624\u8fdb\u5c55\u3001\u7f13\u89e3\u75c7\u72b6\uff0c\u4e5f\u8ba9\u60a3\u8005\u770b\u5230\u4e86\u5e0c\u671b\uff1a\u4ed6\u4eec\u6216\u8bb8\u80fd\u91cd\u65b0\u53c2\u4e0e\u90a3\u4e9b\u5f88\u591a\u4eba\u4e60\u4ee5\u4e3a\u5e38\u7684\u6d3b\u52a8\uff0c\u6bd4\u5982\u722c\u697c\u68af\u3001\u901a\u52e4\u4e0a\u73ed\uff0c\u6216\u662f\u966a\u5b69\u5b50\u73a9\u800d\u3002”<\/p>\n
\u5173\u4e8e\u8d1d\u6377\u8fc8\u00ae\uff08\u76d0\u9178\u5339\u7c73\u66ff\u5c3c\u80f6\u56ca\uff09<\/p>\n
\u8d1d\u6377\u8fc8\u00ae\u662f\u7531\u548c\u8a89\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u6b3e\u65b0\u578b\u3001\u53e3\u670d\u3001\u9ad8\u9009\u62e9\u6027\u4e14\u9ad8\u6548\u7684\u5c0f\u5206\u5b50CSF-1R\u6291\u5236\u5242\uff0c\u6b64\u524d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5df2\u88ab\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\uff0c\u5e76\u88ab\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6388\u4e88\u4f18\u5148\u836f\u7269\uff08PRIME\uff09\u8ba4\u5b9a\u3002\u9ed8\u514b\u62e5\u6709\u8d1d\u6377\u8fc8\u00ae\u7684\u5168\u7403\u5546\u4e1a\u5316\u6743\u76ca\u3002<\/p>\n
SOURCE \u9ed8\u514b<\/p>","protected":false},"excerpt":{"rendered":"
\u57fa\u4e8e\u5168\u7403\u2162\u671fMANEUVER\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u662f\u8d1d\u6377\u8fc8\u00ae\u5728\u5168\u7403\u9996\u4e2a\u6ce8\u518c\u83b7\u6279\u3002\u5728MANEUVER\u7814\u7a76\u4e2d\uff0c\u5728\u7b2c25\u5468\u65f6\uff0c\u8d1d\u6377\u8fc8\u00ae\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe54%\uff0c\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u7ec43.2%\uff0c\u540c\u65f6\u5728\u6240\u6709\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u6307\u6807\u4e2d\u5747\u5b9e\u73b0\u4e86\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u4e14\u7edf\u8ba1\u5b66\u663e\u8457\u7684\u6539\u5584\u3002\u7ecf\u957f\u671f\u968f\u8bbf\u663e\u793a\uff0c\u63a5\u53d7\u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6bcf4\u4f8b\u5373\u67093\u4f8b\u57fa\u4e8eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\u8fbe\u5230\u7f13\u89e3\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6b64\u6b21\u83b7\u6279\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u9ed8\u514b\u5728\u7f55\u89c1\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u9886\u5148\u5730\u4f4d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5728\u5168\u7403\u5176\u4ed6\u5e02\u573a\u7684\u6ce8\u518c\u7533\u8bf7\u4e5f\u5728\u79ef\u6781\u63a8\u8fdb\u4e2d\u3002 \u5317\u4eac2025\u5e7412\u670822\u65e5 \/\u7f8e\u901a\u793e\/ — 2025\u5e7412\u670822\u65e5\uff0c\u5168\u7403\u9886\u5148\u7684\u79d1\u6280\u516c\u53f8\u9ed8\u514b\u4eca\u65e5\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\u6279\u51c6\u8d1d\u6377\u8fc8\u00ae\uff08\u76d0\u9178\u5339\u7c73\u66ff\u5c3c\u80f6\u56ca\uff09\u7528\u4e8e\u624b\u672f\u5207\u9664\u53ef\u80fd\u4f1a\u5bfc\u81f4\u529f\u80fd\u53d7\u9650\u6216\u51fa\u73b0\u8f83\u4e25\u91cd\u5e76\u53d1\u75c7\u7684\u75c7\u72b6\u6027\u8171\u9798\u5de8\u7ec6\u80de\u7624\uff08TGCT\uff09\u6210\u5e74\u60a3\u8005\u3002\u8d1d\u6377\u8fc8\u00ae\u662f\u4e00\u6b3e\u7531\u548c\u8a89\u533b\u836f\u7814\u53d1\u7684\u96c6\u843d\u523a\u6fc0\u56e0\u5b50-1\u53d7\u4f53\uff08CSF-1R\uff09\u6291\u5236\u5242\uff0c\u4e5f\u662f\u56fd\u5185\u9996\u4e2a\u83b7\u6279\u7528\u4e8eTGCT\u6cbb\u7597\u7684\u4e00\u7c7b\u521b\u65b0\u836f\u3002 \u9ed8\u514b\u533b\u836f\u5065\u5eb7\u9996\u5e2d\u6267\u884c\u5b98\u3001\u9ed8\u514b\u6267\u884c\u8463\u4e8b\u4f1a\u6210\u5458\u4e39\u5353\u822a\u8868\u793a\uff1a”\u968f\u7740\u8d1d\u6377\u8fc8\u00ae\u5728\u5168\u7403\u7684\u9996\u4e2a\u6ce8\u518c\u83b7\u6279\uff0c\u6211\u4eec\u6b63\u6301\u7eed\u8df5\u884c\u6539\u5584\u7f55\u89c1\u80bf\u7624\u60a3\u8005\u751f\u6d3b\u7684\u627f\u8bfa\u3002\u6b64\u6b21\u83b7\u6279\u66f4\u662f\u8fdb\u4e00\u6b65\u592f\u5b9e\u6211\u4eec\u5728\u7f55\u89c1\u80bf\u7624\u9886\u5bfc\u5730\u4f4d\u7684\u5173\u952e\u4e00\u6b65\u3002\u6211\u4eec\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u65e2\u80fd\u6539\u53d8\u75be\u75c5\u8fdb\u7a0b\u3001\u53c8\u53ef\u7f13\u89e3\u65e5\u5e38\u75c7\u72b6\u7684\u5e0c\u671b\u3002\u6211\u4eec\u6b63\u5728\u52a0\u901f\u63a8\u8fdb\u8d1d\u6377\u8fc8\u00ae\u65e9\u65e5\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005\uff0c\u5e76\u6301\u7eed\u63a8\u8fdb\u5176\u5728\u5168\u7403\u5176\u4ed6\u5e02\u573a\u7684\u6ce8\u518c\u5e03\u5c40\u3002” TGCT\uff0c\u65e2\u5f80\u53c8\u79f0\u8272\u7d20\u6c89\u7740\u7ed2\u6bdb\u7ed3\u8282\u6027\u6ed1\u819c\u708e\uff08PVNS\uff09\uff0c\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u5c40\u90e8\u4fb5\u88ad\u6027\u80bf\u7624\uff0c\u53ef\u5bfc\u81f4\u53d7\u7d2f\u5173\u8282\u51fa\u73b0\u8fdb\u884c\u6027\u52a0\u91cd\u7684\u80bf\u80c0\u3001\u50f5\u786c\u53ca\u6d3b\u52a8\u529f\u80fd\u53d7\u9650\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u6d3b\u52a8\u80fd\u529b\u548c\u751f\u6d3b\u8d28\u91cf\u3002\u82e5\u4e0d\u8fdb\u884c\u6cbb\u7597\u6216\u75c5\u60c5\u590d\u53d1\uff0c\u53ef\u80fd\u5bf9\u9aa8\u9abc\u3001\u5173\u8282\u53ca\u5468\u56f4\u7ec4\u7ec7\u9020\u6210\u4e0d\u53ef\u9006\u635f\u4f24\u3002 \u8d1d\u6377\u8fc8\u00ae\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671fMANEUVER\u7684\u7814\u7a76\u7ed3\u679c\u3002\u6570\u636e\u663e\u793a\uff0c\u5728\u9488\u5bf9TGCT\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5c55\u73b0\u4e86\u57fa\u4e8eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\u7684\u6700\u9ad8\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u5e76\u4f34\u968f\u4e34\u5e8a\u7ed3\u5c40\u7684\u663e\u8457\u6539\u5584\u3002\u5728\u7b2c25\u5468\u65f6\uff0c\u57fa\u4e8eRECIST v1.1\u6807\u51c6\uff0c\u7ecf\u76f2\u6001\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BIRC\uff09\u8bc4\u4f30\u7684\u4e3b\u8981\u7ec8\u70b9\u7ed3\u679c\u663e\u793a\uff0c\u8d1d\u6377\u8fc8\u00ae\u7684ORR\u76f8\u8f83\u5b89\u6170\u5242\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u4e34\u5e8a\u6539\u5584\uff0854.0% vs. 3.2%\uff1bp<0.0001\uff09\u3002\u540c\u65f6\uff0c\u591a\u4e2a\u4e0e\u60a3\u8005\u65e5\u5e38\u751f\u6d3b\u529f\u80fd\u5bc6\u5207\u76f8\u5173\u7684\u6b21\u8981\u7ec8\u70b9\u4ea6\u663e\u793a\u51fa\u517c\u5177\u4e34\u5e8a\u610f\u4e49\u4e0e\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u6539\u5584\uff0c\u5305\u62ec\u76f8\u5bf9\u5173\u8282\u6d3b\u52a8\u8303\u56f4\u7684\u63d0\u5347\uff08p=0.0003\uff09\u3001\u8eab\u4f53\u529f\u80fd\u7684\u6539\u5584\uff08\u57fa\u4e8e\u8eab\u4f53\u529f\u80fd\u91cf\u8868PROMIS-PF\u8bc4\u4f30\uff0cp=0.0074\uff09\uff0c\u4ee5\u53ca\u6700\u4e25\u91cd\u50f5\u786c\uff08p<0.0001\uff09\u548c\u6700\u4e25\u91cd\u75bc\u75db\uff08p<0.0001\uff09\u7684\u663e\u8457\u51cf\u8f7b\u3002\u4e0a\u8ff0\u7ed3\u679c\u5df2\u57282025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002\u6b64\u5916\uff0c2025\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u516c\u5e03\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u663e\u793a\uff1a\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f414.3\u4e2a\u6708\u65f6\uff0c\u4f9d\u636eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\uff0c\u81ea\u7814\u7a76\u8d77\u59cb\u5373\u63a5\u53d7 \u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u60a3\u8005\u7684ORR\u6301\u7eed\u63d0\u5347\u81f376.2%\uff0895% CI: 63.8, 86.0\uff09\u3002 \u5317\u4eac\u79ef\u6c34\u6f6d\u533b\u9662\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u7597\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u725b\u6653\u8f89\u6559\u6388\u8868\u793a\uff1a”\u5728\u4e2d\u56fd\uff0c\u5f88\u591aTGCT\u60a3\u8005\u957f\u671f\u9762\u4e34\u7740\u6cbb\u7597\u56f0\u5883 \u2014\u2014 \u9664\u624b\u672f\u5916\uff0c\u7f3a\u4e4f\u5176\u4ed6\u7684\u6cbb\u7597\u9009\u62e9\u3002\u800c\u5bf9\u4e8e\u80bf\u7624\u590d\u53d1\u6216\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u60a3\u8005\uff0c\u624b\u672f\u6cbb\u7597\u4e5f\u96be\u4ee5\u6ee1\u8db3\u5176\u9700\u6c42\u3002\u57fa\u4e8e\u5168\u7403MANEUVER\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u8d1d\u6377\u8fc8\u00ae\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u8fd9\u610f\u5473\u7740\u4e34\u5e8a\u533b\u751f\u6709\u673a\u4f1a\u4e3a\u60a3\u8005\u63d0\u4f9b\u7597\u6548\u786e\u5207\u4e14\u8010\u53d7\u6027\u826f\u597d\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u65b9\u6848\uff0c\u4e3a\u8fd9\u4e00\u96be\u6cbb\u6027\u75be\u75c5\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u4e9f\u9700\u7684\u7a81\u7834\u6027\u8fdb\u5c55\u3002” \u5728MANEUVER\u7814\u7a76\u4e2d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u80c6\u6c41\u6de4\u79ef\u6027\u809d\u6bd2\u6027\u6216\u6bdb\u53d1\u53ca\u76ae\u80a4\u8272\u7d20\u51cf\u9000\u7684\u8ff9\u8c61\u3002\u5728\u8be5\u8bd5\u9a8c\u7684\u968f\u673a\u3001\u53cc\u76f2\u6cbb\u7597\u9636\u6bb5\uff0c\u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u7ec4\u4e2d\uff0c\u56e0\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u505c\u836f\u7684\u60c5\u51b5\u89c1\u4e8e1\u4f8b\uff081.6%\uff09\u60a3\u8005\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u51cf\u91cf\u7684\u6bd4\u4f8b\u4e3a7.9%\uff08n=5\uff09\u3002 \u853b\u5fb7\u7f55\u89c1\u75c5\u4e2d\u5fc3\u521b\u59cb\u4eba\u3001\u4e3b\u4efb\uff0c\u745e\u9e25\u516c\u76ca\u57fa\u91d1\u4f1a\u521b\u59cb\u4eba\u3001\u79d8\u4e66\u957f\u9ec4\u5982\u65b9\u5148\u751f\u8868\u793a\uff1a”TGCT\u5f15\u53d1\u7684\u75bc\u75db\u4e0e\u6d3b\u52a8\u53d7\u9650\uff0c\u4f1a\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\uff0c\u7ed9\u4ed6\u4eec\u5e26\u6765\u4e86\u5de8\u5927\u7684\u7cbe\u795e\u538b\u529b\u3002\u968f\u7740\u8d1d\u6377\u8fc8\u00ae\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u8fd9\u4e00\u7c7b\u7cfb\u7edf\u6027\u6cbb\u7597\u65b9\u6848\u80fd\u591f\u6709\u6548\u63a7\u5236\u80bf\u7624\u8fdb\u5c55\u3001\u7f13\u89e3\u75c7\u72b6\uff0c\u4e5f\u8ba9\u60a3\u8005\u770b\u5230\u4e86\u5e0c\u671b\uff1a\u4ed6\u4eec\u6216\u8bb8\u80fd\u91cd\u65b0\u53c2\u4e0e\u90a3\u4e9b\u5f88\u591a\u4eba\u4e60\u4ee5\u4e3a\u5e38\u7684\u6d3b\u52a8\uff0c\u6bd4\u5982\u722c\u697c\u68af\u3001\u901a\u52e4\u4e0a\u73ed\uff0c\u6216\u662f\u966a\u5b69\u5b50\u73a9\u800d\u3002” \u5173\u4e8e\u8d1d\u6377\u8fc8\u00ae\uff08\u76d0\u9178\u5339\u7c73\u66ff\u5c3c\u80f6\u56ca\uff09 \u8d1d\u6377\u8fc8\u00ae\u662f\u7531\u548c\u8a89\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u6b3e\u65b0\u578b\u3001\u53e3\u670d\u3001\u9ad8\u9009\u62e9\u6027\u4e14\u9ad8\u6548\u7684\u5c0f\u5206\u5b50CSF-1R\u6291\u5236\u5242\uff0c\u6b64\u524d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5df2\u88ab\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\uff0c\u5e76\u88ab\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6388\u4e88\u4f18\u5148\u836f\u7269\uff08PRIME\uff09\u8ba4\u5b9a\u3002\u9ed8\u514b\u62e5\u6709\u8d1d\u6377\u8fc8\u00ae\u7684\u5168\u7403\u5546\u4e1a\u5316\u6743\u76ca\u3002 SOURCE \u9ed8\u514b<\/p>\n","protected":false},"author":0,"featured_media":20188,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-20187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n
\u5168\u7403\u9996\u53d1\uff0c\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\uff1a\u8171\u9798\u5de8\u7ec6\u80de\u7624\u6cbb\u7597\u836f\u7269\u8d1d\u6377\u8fc8\u00ae\u5728\u534e\u83b7\u6279 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u5168\u7403\u9996\u53d1\uff0c\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\uff1a\u8171\u9798\u5de8\u7ec6\u80de\u7624\u6cbb\u7597\u836f\u7269\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5168\u7403\u9996\u53d1\uff0c\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\uff1a\u8171\u9798\u5de8\u7ec6\u80de\u7624\u6cbb\u7597\u836f\u7269\u8d1d\u6377\u8fc8\u00ae\u5728\u534e\u83b7\u6279 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u57fa\u4e8e\u5168\u7403\u2162\u671fMANEUVER\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u662f\u8d1d\u6377\u8fc8\u00ae\u5728\u5168\u7403\u9996\u4e2a\u6ce8\u518c\u83b7\u6279\u3002\u5728MANEUVER\u7814\u7a76\u4e2d\uff0c\u5728\u7b2c25\u5468\u65f6\uff0c\u8d1d\u6377\u8fc8\u00ae\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe54%\uff0c\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u7ec43.2%\uff0c\u540c\u65f6\u5728\u6240\u6709\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u6307\u6807\u4e2d\u5747\u5b9e\u73b0\u4e86\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u4e14\u7edf\u8ba1\u5b66\u663e\u8457\u7684\u6539\u5584\u3002\u7ecf\u957f\u671f\u968f\u8bbf\u663e\u793a\uff0c\u63a5\u53d7\u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6bcf4\u4f8b\u5373\u67093\u4f8b\u57fa\u4e8eRECIST 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TGCT\uff0c\u65e2\u5f80\u53c8\u79f0\u8272\u7d20\u6c89\u7740\u7ed2\u6bdb\u7ed3\u8282\u6027\u6ed1\u819c\u708e\uff08PVNS\uff09\uff0c\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u5c40\u90e8\u4fb5\u88ad\u6027\u80bf\u7624\uff0c\u53ef\u5bfc\u81f4\u53d7\u7d2f\u5173\u8282\u51fa\u73b0\u8fdb\u884c\u6027\u52a0\u91cd\u7684\u80bf\u80c0\u3001\u50f5\u786c\u53ca\u6d3b\u52a8\u529f\u80fd\u53d7\u9650\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u6d3b\u52a8\u80fd\u529b\u548c\u751f\u6d3b\u8d28\u91cf\u3002\u82e5\u4e0d\u8fdb\u884c\u6cbb\u7597\u6216\u75c5\u60c5\u590d\u53d1\uff0c\u53ef\u80fd\u5bf9\u9aa8\u9abc\u3001\u5173\u8282\u53ca\u5468\u56f4\u7ec4\u7ec7\u9020\u6210\u4e0d\u53ef\u9006\u635f\u4f24\u3002 \u8d1d\u6377\u8fc8\u00ae\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671fMANEUVER\u7684\u7814\u7a76\u7ed3\u679c\u3002\u6570\u636e\u663e\u793a\uff0c\u5728\u9488\u5bf9TGCT\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5c55\u73b0\u4e86\u57fa\u4e8eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\u7684\u6700\u9ad8\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u5e76\u4f34\u968f\u4e34\u5e8a\u7ed3\u5c40\u7684\u663e\u8457\u6539\u5584\u3002\u5728\u7b2c25\u5468\u65f6\uff0c\u57fa\u4e8eRECIST v1.1\u6807\u51c6\uff0c\u7ecf\u76f2\u6001\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BIRC\uff09\u8bc4\u4f30\u7684\u4e3b\u8981\u7ec8\u70b9\u7ed3\u679c\u663e\u793a\uff0c\u8d1d\u6377\u8fc8\u00ae\u7684ORR\u76f8\u8f83\u5b89\u6170\u5242\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u4e34\u5e8a\u6539\u5584\uff0854.0% vs. 3.2%\uff1bp<0.0001\uff09\u3002\u540c\u65f6\uff0c\u591a\u4e2a\u4e0e\u60a3\u8005\u65e5\u5e38\u751f\u6d3b\u529f\u80fd\u5bc6\u5207\u76f8\u5173\u7684\u6b21\u8981\u7ec8\u70b9\u4ea6\u663e\u793a\u51fa\u517c\u5177\u4e34\u5e8a\u610f\u4e49\u4e0e\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u6539\u5584\uff0c\u5305\u62ec\u76f8\u5bf9\u5173\u8282\u6d3b\u52a8\u8303\u56f4\u7684\u63d0\u5347\uff08p=0.0003\uff09\u3001\u8eab\u4f53\u529f\u80fd\u7684\u6539\u5584\uff08\u57fa\u4e8e\u8eab\u4f53\u529f\u80fd\u91cf\u8868PROMIS-PF\u8bc4\u4f30\uff0cp=0.0074\uff09\uff0c\u4ee5\u53ca\u6700\u4e25\u91cd\u50f5\u786c\uff08p<0.0001\uff09\u548c\u6700\u4e25\u91cd\u75bc\u75db\uff08p<0.0001\uff09\u7684\u663e\u8457\u51cf\u8f7b\u3002\u4e0a\u8ff0\u7ed3\u679c\u5df2\u57282025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002\u6b64\u5916\uff0c2025\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u516c\u5e03\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u663e\u793a\uff1a\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f414.3\u4e2a\u6708\u65f6\uff0c\u4f9d\u636eRECIST v1.1\u6807\u51c6\u8bc4\u4f30\uff0c\u81ea\u7814\u7a76\u8d77\u59cb\u5373\u63a5\u53d7 \u8d1d\u6377\u8fc8\u00ae\u6cbb\u7597\u60a3\u8005\u7684ORR\u6301\u7eed\u63d0\u5347\u81f376.2%\uff0895% CI: 63.8, 86.0\uff09\u3002 \u5317\u4eac\u79ef\u6c34\u6f6d\u533b\u9662\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u8bca\u7597\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u725b\u6653\u8f89\u6559\u6388\u8868\u793a\uff1a”\u5728\u4e2d\u56fd\uff0c\u5f88\u591aTGCT\u60a3\u8005\u957f\u671f\u9762\u4e34\u7740\u6cbb\u7597\u56f0\u5883 \u2014\u2014 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\u5173\u4e8e\u8d1d\u6377\u8fc8\u00ae\uff08\u76d0\u9178\u5339\u7c73\u66ff\u5c3c\u80f6\u56ca\uff09 \u8d1d\u6377\u8fc8\u00ae\u662f\u7531\u548c\u8a89\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u6b3e\u65b0\u578b\u3001\u53e3\u670d\u3001\u9ad8\u9009\u62e9\u6027\u4e14\u9ad8\u6548\u7684\u5c0f\u5206\u5b50CSF-1R\u6291\u5236\u5242\uff0c\u6b64\u524d\uff0c\u8d1d\u6377\u8fc8\u00ae\u5df2\u88ab\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\uff0c\u5e76\u88ab\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6388\u4e88\u4f18\u5148\u836f\u7269\uff08PRIME\uff09\u8ba4\u5b9a\u3002\u9ed8\u514b\u62e5\u6709\u8d1d\u6377\u8fc8\u00ae\u7684\u5168\u7403\u5546\u4e1a\u5316\u6743\u76ca\u3002 SOURCE \u9ed8\u514b\" \/>\n<meta property=\"og:url\" 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