{"id":2150,"date":"2024-10-10T02:57:00","date_gmt":"2024-10-10T02:57:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/"},"modified":"2024-10-10T02:57:00","modified_gmt":"2024-10-10T02:57:00","slug":"%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/","title":{"rendered":"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u4e2d\u56fd\u82cf\u5dde\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e39<\/span><span class=\"legendSpanClass\">2024\u5e7410\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u9886\u57df\u521b\u65b0\u6297\u4f53\u7597\u6cd5\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u533b\u836f\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u5168\u7403\u9996\u6b3e\u9776\u5411\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u8054\u5408<span>\u6297<\/span><span>PD-1\u6297\u4f53<\/span><span>\u7279\u745e<\/span>\u666e\u5229\u5355\u6297\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5df2\u5728\u7ebf\u53d1\u8868\u4e8eJournal for ImmunoTherapy of Cancer\uff082023\u5e74\u5f71\u54cd\u56e0\u5b50\uff1a10.3\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/1096360\/HB_for_email_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>\u8be5\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9ed1\u8272\u7d20\u7624\u4e0e\u8089\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u90ed\u519b\u6559\u6388\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297<span>\u4e0e\u6297<\/span><span>PD-1\u6297\u4f53<\/span>\u8054\u5408\u7528\u836f\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u6b64\u5916\uff0c\u521d\u6b65\u7814\u7a76\u7ed3\u679c\u53d1\u73b0\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u5b9e\u4f53\u7624\uff0c\u5c24\u5176<span>\u662f\u6297PD-1\u521d\u6cbb\u7684<\/span>\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p>\u6297CTLA-4\u548c\u6297PD-1\u7684\u53cc\u514d\u75ab\u8054\u5408\u7597\u6cd5\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4f5c\u4e3a\u9ed1\u8272\u7d20\u7624\u3001\u80be\u7ec6\u80de\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u524d\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u4f20\u7edf\u6297CTLA-4\u6297\u4f53\u7684\u5b89\u5168\u6027\u95ee\u9898\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u548c\u94c2\u533b\u836f\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u3002\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u76f8\u8f83\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\u5177\u6709\u66f4\u4f18\u5f02\u7684\u7279\u6027\uff0c\u6709\u671b\u7a81\u7834\u5f53\u524dCTLA-4\u7597\u6cd5\u7684\u7597\u6548\u53ca\u6bd2\u6027\u74f6\u9888\uff0c\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6838\u5fc3\u4ea7\u54c1\u3002<\/p>\n<p>\u8be5\u9879I\u671f\u4e34\u5e8a\u7814\u7a76\u5305\u62ec\u5242\u91cf\u9012\u589e\u548c\u5242\u91cf\u6269\u5c55\u4e24\u4e2a\u9636\u6bb5\uff0c\u5171\u5165\u7ec440\u4f8b\u60a3\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u514d\u75ab\u539f\u6027\u548c\u521d\u6b65\u7597\u6548\u3002<\/p>\n<p>\u5b89\u5168\u6027\u7ed3\u679c<\/p>\n<p>\u5728\u63a5\u53d7\u6cbb\u7597\u768440\u4f8b\u60a3\u8005\u4e2d\uff0c10\u4f8b\uff0825.0%\uff09\u60a3\u8005\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\u3002\u5e38\u89c1\u7684TRAEs\u4e3a\u76ae\u75b9\uff0830.0%\uff09\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff0830.0%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\uff0825.0%\uff09\u548c\u53d1\u70ed\uff0820.0%\uff09\u3002\u6b64\u5916\uff0c5\u4f8b\uff0812.5%\uff09\u60a3\u8005\u53d1\u751f\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\uff0c\u6700\u4e25\u91cd\u7a0b\u5ea6\u4e3a3\u7ea7\uff0c\u672a\u53d1\u751f4\u7ea7\u62165\u7ea7irAEs\u3002<\/p>\n<p>\u7597\u6548\u7ed3\u679c<\/p>\n<p>\u5bf932\u4f8b\u63a5\u53d7II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u6cbb\u7597\uff0c\u5373\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u8054\u5408\u56fa\u5b9a\u5242\u91cf\u7279\u745e\u666e\u5229\u5355\u6297240 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u7ed9\u836f\uff0c\u4e14\u6709\u57fa\u7ebf\u540e\u5f71\u50cf\u5b66\u6570\u636e\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u7597\u6548\u5206\u6790\uff0c<span>\u6297<\/span><span>PD-1\/PD-L1<\/span><span>\u521d\u6cbb\u4e9a\u7ec4<\/span>\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a33.3%\u3002\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u8be5\u4e9a\u7ec4\u7684ORR\u4e3a40.0%\u3002\u57fa\u7ebf\u80bf\u7624Treg\/CD4+\u6bd4\u503c\u9ad8\u662f\u514d\u75ab\u7597\u6cd5\u6709\u6548\u7684\u72ec\u7acb\u9884\u6d4b\u56e0\u7d20\u3002<\/p>\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u548c\u7279\u745e\u666e\u5229\u5355\u6297240 mg Q3W\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff08\u5305\u62ec\u96be\u4ee5\u6cbb\u7597\u7684\u9ecf\u819c\u4e9a\u578b\u9ed1\u8272\u7d20\u7624\uff09\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u540e\u7eed\u4ecd\u9700\u66f4\u591a\u7814\u7a76\u6765\u8bc1\u5b9e\u8be5\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u3002<\/p>\n<p>\u548c\u94c2\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u52b2\u677e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u666e\u9c81\u82cf\u62dc\u5355\u6297\u548c\u6297PD-1\u6297\u4f53\u8054\u5408\u7597\u6cd5\u5728I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u516c\u53f8\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u9996\u6b3e\u81ea\u6709\u6297\u4f53\u5206\u5b50,\u6211\u4eec\u671f\u5f85\u63a8\u8fdb\u540e\u7eed\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u63a2\u7d22\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u5f53\u524d\u9886\u57df\u672a\u6ee1\u8db3\u533b\u5b66\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u6700\u7ec8\u4e3a\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u6709\u610f\u4e49\u7684\u6539\u53d8\u3002&#8221;<\/p>\n<p>\u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297<\/p>\n<p>\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u6297CTLA-4\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\uff08HCAb\uff09\uff0c\u4ea7\u751f\u81ea\u548c\u94c2\u533b\u836f\u4e13\u6709\u7684 Harbour Mice\u00ae\u5e73\u53f0\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\u3002HBM4003\u663e\u793a\u51fa\u589e\u5f3a\u7684ADCC\uff08\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff09\u6d3b\u6027\uff0c\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9ad8\u8868\u8fbeCTLA-4\u7684Treg\u7ec6\u80de\u5177\u6709\u6781\u9ad8\u7684\u7279\u5f02\u6027\u3002\u5176\u5f3a\u6548\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3001\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u6301\u4e45\u7684\u836f\u6548\u5c55\u73b0\u51fa\u826f\u597d\u7684\u4ea7\u54c1\u7279\u6027\uff0c\u8fd9\u79cd\u65b0\u9896\u548c\u5dee\u5f02\u5316\u7684\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u5177\u6709\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u5e76\u663e\u8457\u964d\u4f4e\u836f\u7269\u6bd2\u6027\u7684\u6f5c\u529b\u3002<\/p>\n<p>\u5173\u4e8e\u548c\u94c2\u533b\u836f<br \/>\u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002<br \/>\u548c\u94c2\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour Mice\u00ae\u53ef\u751f\u6210\u53cc\u91cd\u3001\u53cc\u8f7b\u94fe\uff08H2L2\uff09\u548c\u4ec5\u91cd\u94fe\uff08HCAb\uff09\u5f62\u5f0f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u57fa\u4e8eHCAb\u6297\u4f53\u5e73\u53f0\u5f00\u53d1\u7684\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\uff08HBICE\u00ae\uff09\u53cc\u6297\u6280\u672f\u80fd\u591f\u5b9e\u73b0\u4f20\u7edf\u836f\u7269\u8054\u5408\u7597\u6cd5\u65e0\u6cd5\u8fbe\u5230\u7684\u6297\u80bf\u7624\u7597\u6548\u3002Harbour Mice\u00ae\uff0cHBICE\u00ae\u4e0e\u5355B\u7ec6\u80de\u514b\u9686\u7b5b\u9009\u5e73\u53f0\u5171\u540c\u7ec4\u6210\u4e86\u548c\u94c2\u7684\u4e0b\u4e00\u4ee3\u521b\u65b0\u6cbb\u7597\u6027\u6297\u4f53\u7814\u53d1\u5f15\u64ce\u3002\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u8bbf\u95ee\uff1a<a href=\"http:\/\/www.harbourbiomed.com\/\" target=\"_blank\" rel=\"noopener\">www.harbourbiomed.com<\/a>\u3002<\/p>\n<p>SOURCE  \u548c\u94c2\u533b\u836f<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e392024\u5e7410\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u9886\u57df\u521b\u65b0\u6297\u4f53\u7597\u6cd5\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u533b\u836f\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u5168\u7403\u9996\u6b3e\u9776\u5411\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u8054\u5408\u6297PD-1\u6297\u4f53\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5df2\u5728\u7ebf\u53d1\u8868\u4e8eJournal for ImmunoTherapy of Cancer\uff082023\u5e74\u5f71\u54cd\u56e0\u5b50\uff1a10.3\uff09\u3002 \u8be5\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9ed1\u8272\u7d20\u7624\u4e0e\u8089\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u90ed\u519b\u6559\u6388\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u4e0e\u6297PD-1\u6297\u4f53\u8054\u5408\u7528\u836f\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u6b64\u5916\uff0c\u521d\u6b65\u7814\u7a76\u7ed3\u679c\u53d1\u73b0\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u5b9e\u4f53\u7624\uff0c\u5c24\u5176\u662f\u6297PD-1\u521d\u6cbb\u7684\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u6297CTLA-4\u548c\u6297PD-1\u7684\u53cc\u514d\u75ab\u8054\u5408\u7597\u6cd5\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4f5c\u4e3a\u9ed1\u8272\u7d20\u7624\u3001\u80be\u7ec6\u80de\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u524d\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u4f20\u7edf\u6297CTLA-4\u6297\u4f53\u7684\u5b89\u5168\u6027\u95ee\u9898\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u548c\u94c2\u533b\u836f\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u3002\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u76f8\u8f83\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\u5177\u6709\u66f4\u4f18\u5f02\u7684\u7279\u6027\uff0c\u6709\u671b\u7a81\u7834\u5f53\u524dCTLA-4\u7597\u6cd5\u7684\u7597\u6548\u53ca\u6bd2\u6027\u74f6\u9888\uff0c\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6838\u5fc3\u4ea7\u54c1\u3002 \u8be5\u9879I\u671f\u4e34\u5e8a\u7814\u7a76\u5305\u62ec\u5242\u91cf\u9012\u589e\u548c\u5242\u91cf\u6269\u5c55\u4e24\u4e2a\u9636\u6bb5\uff0c\u5171\u5165\u7ec440\u4f8b\u60a3\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u514d\u75ab\u539f\u6027\u548c\u521d\u6b65\u7597\u6548\u3002 \u5b89\u5168\u6027\u7ed3\u679c \u5728\u63a5\u53d7\u6cbb\u7597\u768440\u4f8b\u60a3\u8005\u4e2d\uff0c10\u4f8b\uff0825.0%\uff09\u60a3\u8005\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\u3002\u5e38\u89c1\u7684TRAEs\u4e3a\u76ae\u75b9\uff0830.0%\uff09\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff0830.0%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\uff0825.0%\uff09\u548c\u53d1\u70ed\uff0820.0%\uff09\u3002\u6b64\u5916\uff0c5\u4f8b\uff0812.5%\uff09\u60a3\u8005\u53d1\u751f\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\uff0c\u6700\u4e25\u91cd\u7a0b\u5ea6\u4e3a3\u7ea7\uff0c\u672a\u53d1\u751f4\u7ea7\u62165\u7ea7irAEs\u3002 \u7597\u6548\u7ed3\u679c \u5bf932\u4f8b\u63a5\u53d7II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u6cbb\u7597\uff0c\u5373\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u8054\u5408\u56fa\u5b9a\u5242\u91cf\u7279\u745e\u666e\u5229\u5355\u6297240 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u7ed9\u836f\uff0c\u4e14\u6709\u57fa\u7ebf\u540e\u5f71\u50cf\u5b66\u6570\u636e\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u7597\u6548\u5206\u6790\uff0c\u6297PD-1\/PD-L1\u521d\u6cbb\u4e9a\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a33.3%\u3002\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u8be5\u4e9a\u7ec4\u7684ORR\u4e3a40.0%\u3002\u57fa\u7ebf\u80bf\u7624Treg\/CD4+\u6bd4\u503c\u9ad8\u662f\u514d\u75ab\u7597\u6cd5\u6709\u6548\u7684\u72ec\u7acb\u9884\u6d4b\u56e0\u7d20\u3002 \u603b\u4f53\u800c\u8a00\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u548c\u7279\u745e\u666e\u5229\u5355\u6297240 mg Q3W\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff08\u5305\u62ec\u96be\u4ee5\u6cbb\u7597\u7684\u9ecf\u819c\u4e9a\u578b\u9ed1\u8272\u7d20\u7624\uff09\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u540e\u7eed\u4ecd\u9700\u66f4\u591a\u7814\u7a76\u6765\u8bc1\u5b9e\u8be5\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u3002 \u548c\u94c2\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u52b2\u677e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u666e\u9c81\u82cf\u62dc\u5355\u6297\u548c\u6297PD-1\u6297\u4f53\u8054\u5408\u7597\u6cd5\u5728I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u516c\u53f8\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u9996\u6b3e\u81ea\u6709\u6297\u4f53\u5206\u5b50,\u6211\u4eec\u671f\u5f85\u63a8\u8fdb\u540e\u7eed\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u63a2\u7d22\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u5f53\u524d\u9886\u57df\u672a\u6ee1\u8db3\u533b\u5b66\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u6700\u7ec8\u4e3a\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u6709\u610f\u4e49\u7684\u6539\u53d8\u3002&#8221; \u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297 \u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u6297CTLA-4\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\uff08HCAb\uff09\uff0c\u4ea7\u751f\u81ea\u548c\u94c2\u533b\u836f\u4e13\u6709\u7684 Harbour Mice\u00ae\u5e73\u53f0\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\u3002HBM4003\u663e\u793a\u51fa\u589e\u5f3a\u7684ADCC\uff08\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff09\u6d3b\u6027\uff0c\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9ad8\u8868\u8fbeCTLA-4\u7684Treg\u7ec6\u80de\u5177\u6709\u6781\u9ad8\u7684\u7279\u5f02\u6027\u3002\u5176\u5f3a\u6548\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3001\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u6301\u4e45\u7684\u836f\u6548\u5c55\u73b0\u51fa\u826f\u597d\u7684\u4ea7\u54c1\u7279\u6027\uff0c\u8fd9\u79cd\u65b0\u9896\u548c\u5dee\u5f02\u5316\u7684\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u5177\u6709\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u5e76\u663e\u8457\u964d\u4f4e\u836f\u7269\u6bd2\u6027\u7684\u6f5c\u529b\u3002 \u5173\u4e8e\u548c\u94c2\u533b\u836f\u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002\u548c\u94c2\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour Mice\u00ae\u53ef\u751f\u6210\u53cc\u91cd\u3001\u53cc\u8f7b\u94fe\uff08H2L2\uff09\u548c\u4ec5\u91cd\u94fe\uff08HCAb\uff09\u5f62\u5f0f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u57fa\u4e8eHCAb\u6297\u4f53\u5e73\u53f0\u5f00\u53d1\u7684\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\uff08HBICE\u00ae\uff09\u53cc\u6297\u6280\u672f\u80fd\u591f\u5b9e\u73b0\u4f20\u7edf\u836f\u7269\u8054\u5408\u7597\u6cd5\u65e0\u6cd5\u8fbe\u5230\u7684\u6297\u80bf\u7624\u7597\u6548\u3002Harbour Mice\u00ae\uff0cHBICE\u00ae\u4e0e\u5355B\u7ec6\u80de\u514b\u9686\u7b5b\u9009\u5e73\u53f0\u5171\u540c\u7ec4\u6210\u4e86\u548c\u94c2\u7684\u4e0b\u4e00\u4ee3\u521b\u65b0\u6cbb\u7597\u6027\u6297\u4f53\u7814\u53d1\u5f15\u64ce\u3002\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u8bbf\u95ee\uff1awww.harbourbiomed.com\u3002 SOURCE \u548c\u94c2\u533b\u836f<\/p>\n","protected":false},"author":0,"featured_media":2151,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-2150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297pd-1\u6297\u4f53\u6cbb\u7597\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u4e2d\u56fd\u82cf\u5dde\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e392024\u5e7410\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u9886\u57df\u521b\u65b0\u6297\u4f53\u7597\u6cd5\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u533b\u836f\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u5168\u7403\u9996\u6b3e\u9776\u5411\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u8054\u5408\u6297PD-1\u6297\u4f53\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5df2\u5728\u7ebf\u53d1\u8868\u4e8eJournal for ImmunoTherapy of Cancer\uff082023\u5e74\u5f71\u54cd\u56e0\u5b50\uff1a10.3\uff09\u3002 \u8be5\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9ed1\u8272\u7d20\u7624\u4e0e\u8089\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u90ed\u519b\u6559\u6388\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u4e0e\u6297PD-1\u6297\u4f53\u8054\u5408\u7528\u836f\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u6b64\u5916\uff0c\u521d\u6b65\u7814\u7a76\u7ed3\u679c\u53d1\u73b0\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u5b9e\u4f53\u7624\uff0c\u5c24\u5176\u662f\u6297PD-1\u521d\u6cbb\u7684\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u6297CTLA-4\u548c\u6297PD-1\u7684\u53cc\u514d\u75ab\u8054\u5408\u7597\u6cd5\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4f5c\u4e3a\u9ed1\u8272\u7d20\u7624\u3001\u80be\u7ec6\u80de\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u524d\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u4f20\u7edf\u6297CTLA-4\u6297\u4f53\u7684\u5b89\u5168\u6027\u95ee\u9898\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u548c\u94c2\u533b\u836f\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u3002\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u76f8\u8f83\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\u5177\u6709\u66f4\u4f18\u5f02\u7684\u7279\u6027\uff0c\u6709\u671b\u7a81\u7834\u5f53\u524dCTLA-4\u7597\u6cd5\u7684\u7597\u6548\u53ca\u6bd2\u6027\u74f6\u9888\uff0c\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6838\u5fc3\u4ea7\u54c1\u3002 \u8be5\u9879I\u671f\u4e34\u5e8a\u7814\u7a76\u5305\u62ec\u5242\u91cf\u9012\u589e\u548c\u5242\u91cf\u6269\u5c55\u4e24\u4e2a\u9636\u6bb5\uff0c\u5171\u5165\u7ec440\u4f8b\u60a3\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u514d\u75ab\u539f\u6027\u548c\u521d\u6b65\u7597\u6548\u3002 \u5b89\u5168\u6027\u7ed3\u679c \u5728\u63a5\u53d7\u6cbb\u7597\u768440\u4f8b\u60a3\u8005\u4e2d\uff0c10\u4f8b\uff0825.0%\uff09\u60a3\u8005\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\u3002\u5e38\u89c1\u7684TRAEs\u4e3a\u76ae\u75b9\uff0830.0%\uff09\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff0830.0%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\uff0825.0%\uff09\u548c\u53d1\u70ed\uff0820.0%\uff09\u3002\u6b64\u5916\uff0c5\u4f8b\uff0812.5%\uff09\u60a3\u8005\u53d1\u751f\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\uff0c\u6700\u4e25\u91cd\u7a0b\u5ea6\u4e3a3\u7ea7\uff0c\u672a\u53d1\u751f4\u7ea7\u62165\u7ea7irAEs\u3002 \u7597\u6548\u7ed3\u679c \u5bf932\u4f8b\u63a5\u53d7II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u6cbb\u7597\uff0c\u5373\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u8054\u5408\u56fa\u5b9a\u5242\u91cf\u7279\u745e\u666e\u5229\u5355\u6297240 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u7ed9\u836f\uff0c\u4e14\u6709\u57fa\u7ebf\u540e\u5f71\u50cf\u5b66\u6570\u636e\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u7597\u6548\u5206\u6790\uff0c\u6297PD-1\/PD-L1\u521d\u6cbb\u4e9a\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a33.3%\u3002\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u8be5\u4e9a\u7ec4\u7684ORR\u4e3a40.0%\u3002\u57fa\u7ebf\u80bf\u7624Treg\/CD4+\u6bd4\u503c\u9ad8\u662f\u514d\u75ab\u7597\u6cd5\u6709\u6548\u7684\u72ec\u7acb\u9884\u6d4b\u56e0\u7d20\u3002 \u603b\u4f53\u800c\u8a00\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u548c\u7279\u745e\u666e\u5229\u5355\u6297240 mg Q3W\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff08\u5305\u62ec\u96be\u4ee5\u6cbb\u7597\u7684\u9ecf\u819c\u4e9a\u578b\u9ed1\u8272\u7d20\u7624\uff09\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u540e\u7eed\u4ecd\u9700\u66f4\u591a\u7814\u7a76\u6765\u8bc1\u5b9e\u8be5\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u3002 \u548c\u94c2\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u52b2\u677e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u666e\u9c81\u82cf\u62dc\u5355\u6297\u548c\u6297PD-1\u6297\u4f53\u8054\u5408\u7597\u6cd5\u5728I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u516c\u53f8\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u9996\u6b3e\u81ea\u6709\u6297\u4f53\u5206\u5b50,\u6211\u4eec\u671f\u5f85\u63a8\u8fdb\u540e\u7eed\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u63a2\u7d22\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u5f53\u524d\u9886\u57df\u672a\u6ee1\u8db3\u533b\u5b66\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u6700\u7ec8\u4e3a\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u6709\u610f\u4e49\u7684\u6539\u53d8\u3002&#8221; \u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297 \u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u6297CTLA-4\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\uff08HCAb\uff09\uff0c\u4ea7\u751f\u81ea\u548c\u94c2\u533b\u836f\u4e13\u6709\u7684 Harbour Mice\u00ae\u5e73\u53f0\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\u3002HBM4003\u663e\u793a\u51fa\u589e\u5f3a\u7684ADCC\uff08\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff09\u6d3b\u6027\uff0c\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9ad8\u8868\u8fbeCTLA-4\u7684Treg\u7ec6\u80de\u5177\u6709\u6781\u9ad8\u7684\u7279\u5f02\u6027\u3002\u5176\u5f3a\u6548\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3001\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u6301\u4e45\u7684\u836f\u6548\u5c55\u73b0\u51fa\u826f\u597d\u7684\u4ea7\u54c1\u7279\u6027\uff0c\u8fd9\u79cd\u65b0\u9896\u548c\u5dee\u5f02\u5316\u7684\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u5177\u6709\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u5e76\u663e\u8457\u964d\u4f4e\u836f\u7269\u6bd2\u6027\u7684\u6f5c\u529b\u3002 \u5173\u4e8e\u548c\u94c2\u533b\u836f\u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002\u548c\u94c2\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour Mice\u00ae\u53ef\u751f\u6210\u53cc\u91cd\u3001\u53cc\u8f7b\u94fe\uff08H2L2\uff09\u548c\u4ec5\u91cd\u94fe\uff08HCAb\uff09\u5f62\u5f0f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u57fa\u4e8eHCAb\u6297\u4f53\u5e73\u53f0\u5f00\u53d1\u7684\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\uff08HBICE\u00ae\uff09\u53cc\u6297\u6280\u672f\u80fd\u591f\u5b9e\u73b0\u4f20\u7edf\u836f\u7269\u8054\u5408\u7597\u6cd5\u65e0\u6cd5\u8fbe\u5230\u7684\u6297\u80bf\u7624\u7597\u6548\u3002Harbour Mice\u00ae\uff0cHBICE\u00ae\u4e0e\u5355B\u7ec6\u80de\u514b\u9686\u7b5b\u9009\u5e73\u53f0\u5171\u540c\u7ec4\u6210\u4e86\u548c\u94c2\u7684\u4e0b\u4e00\u4ee3\u521b\u65b0\u6cbb\u7597\u6027\u6297\u4f53\u7814\u53d1\u5f15\u64ce\u3002\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u8bbf\u95ee\uff1awww.harbourbiomed.com\u3002 SOURCE \u548c\u94c2\u533b\u836f\" \/>\n<meta property=\"og:url\" content=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297pd-1\u6297\u4f53\u6cbb\u7597\/\" \/>\n<meta property=\"og:site_name\" content=\"Money Compass CN\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-10T02:57:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"144\" \/>\n\t<meta property=\"og:image:height\" content=\"57\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/\",\"name\":\"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868 - Money Compass CN\",\"isPartOf\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg\",\"datePublished\":\"2024-10-10T02:57:00+00:00\",\"dateModified\":\"2024-10-10T02:57:00+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#primaryimage\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg\",\"contentUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg\",\"width\":144,\"height\":57},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/moneycompass.com.my\/cn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/\",\"name\":\"Money Compass CN\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868 - Money Compass CN","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/moneycompass.com.my\/cn\/\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297pd-1\u6297\u4f53\u6cbb\u7597\/","og_locale":"en_US","og_type":"article","og_title":"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868 - Money Compass CN","og_description":"\u4e2d\u56fd\u82cf\u5dde\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e392024\u5e7410\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u9886\u57df\u521b\u65b0\u6297\u4f53\u7597\u6cd5\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u533b\u836f\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u5168\u7403\u9996\u6b3e\u9776\u5411\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u8054\u5408\u6297PD-1\u6297\u4f53\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5df2\u5728\u7ebf\u53d1\u8868\u4e8eJournal for ImmunoTherapy of Cancer\uff082023\u5e74\u5f71\u54cd\u56e0\u5b50\uff1a10.3\uff09\u3002 \u8be5\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9ed1\u8272\u7d20\u7624\u4e0e\u8089\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u90ed\u519b\u6559\u6388\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u4e0e\u6297PD-1\u6297\u4f53\u8054\u5408\u7528\u836f\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u6b64\u5916\uff0c\u521d\u6b65\u7814\u7a76\u7ed3\u679c\u53d1\u73b0\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u5b9e\u4f53\u7624\uff0c\u5c24\u5176\u662f\u6297PD-1\u521d\u6cbb\u7684\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u6297CTLA-4\u548c\u6297PD-1\u7684\u53cc\u514d\u75ab\u8054\u5408\u7597\u6cd5\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4f5c\u4e3a\u9ed1\u8272\u7d20\u7624\u3001\u80be\u7ec6\u80de\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u524d\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u4f20\u7edf\u6297CTLA-4\u6297\u4f53\u7684\u5b89\u5168\u6027\u95ee\u9898\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u548c\u94c2\u533b\u836f\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u4e0b\u4e00\u4ee3\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u3002\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u76f8\u8f83\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\u5177\u6709\u66f4\u4f18\u5f02\u7684\u7279\u6027\uff0c\u6709\u671b\u7a81\u7834\u5f53\u524dCTLA-4\u7597\u6cd5\u7684\u7597\u6548\u53ca\u6bd2\u6027\u74f6\u9888\uff0c\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6838\u5fc3\u4ea7\u54c1\u3002 \u8be5\u9879I\u671f\u4e34\u5e8a\u7814\u7a76\u5305\u62ec\u5242\u91cf\u9012\u589e\u548c\u5242\u91cf\u6269\u5c55\u4e24\u4e2a\u9636\u6bb5\uff0c\u5171\u5165\u7ec440\u4f8b\u60a3\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\uff08\u5c24\u5176\u662f\u9ed1\u8272\u7d20\u7624\uff09\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u514d\u75ab\u539f\u6027\u548c\u521d\u6b65\u7597\u6548\u3002 \u5b89\u5168\u6027\u7ed3\u679c \u5728\u63a5\u53d7\u6cbb\u7597\u768440\u4f8b\u60a3\u8005\u4e2d\uff0c10\u4f8b\uff0825.0%\uff09\u60a3\u8005\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\u3002\u5e38\u89c1\u7684TRAEs\u4e3a\u76ae\u75b9\uff0830.0%\uff09\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff0830.0%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\uff0825.0%\uff09\u548c\u53d1\u70ed\uff0820.0%\uff09\u3002\u6b64\u5916\uff0c5\u4f8b\uff0812.5%\uff09\u60a3\u8005\u53d1\u751f\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\uff0c\u6700\u4e25\u91cd\u7a0b\u5ea6\u4e3a3\u7ea7\uff0c\u672a\u53d1\u751f4\u7ea7\u62165\u7ea7irAEs\u3002 \u7597\u6548\u7ed3\u679c \u5bf932\u4f8b\u63a5\u53d7II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u6cbb\u7597\uff0c\u5373\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u8054\u5408\u56fa\u5b9a\u5242\u91cf\u7279\u745e\u666e\u5229\u5355\u6297240 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u7ed9\u836f\uff0c\u4e14\u6709\u57fa\u7ebf\u540e\u5f71\u50cf\u5b66\u6570\u636e\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u7597\u6548\u5206\u6790\uff0c\u6297PD-1\/PD-L1\u521d\u6cbb\u4e9a\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a33.3%\u3002\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u8be5\u4e9a\u7ec4\u7684ORR\u4e3a40.0%\u3002\u57fa\u7ebf\u80bf\u7624Treg\/CD4+\u6bd4\u503c\u9ad8\u662f\u514d\u75ab\u7597\u6cd5\u6709\u6548\u7684\u72ec\u7acb\u9884\u6d4b\u56e0\u7d20\u3002 \u603b\u4f53\u800c\u8a00\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u62970.3 mg\/kg\u548c\u7279\u745e\u666e\u5229\u5355\u6297240 mg Q3W\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff08\u5305\u62ec\u96be\u4ee5\u6cbb\u7597\u7684\u9ecf\u819c\u4e9a\u578b\u9ed1\u8272\u7d20\u7624\uff09\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u540e\u7eed\u4ecd\u9700\u66f4\u591a\u7814\u7a76\u6765\u8bc1\u5b9e\u8be5\u8054\u5408\u7597\u6cd5\u7684\u7597\u6548\u3002 \u548c\u94c2\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u52b2\u677e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u666e\u9c81\u82cf\u62dc\u5355\u6297\u548c\u6297PD-1\u6297\u4f53\u8054\u5408\u7597\u6cd5\u5728I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u666e\u9c81\u82cf\u62dc\u5355\u6297\u662f\u516c\u53f8\u57fa\u4e8eHCAb Harbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u9996\u6b3e\u81ea\u6709\u6297\u4f53\u5206\u5b50,\u6211\u4eec\u671f\u5f85\u63a8\u8fdb\u540e\u7eed\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u63a2\u7d22\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u5f53\u524d\u9886\u57df\u672a\u6ee1\u8db3\u533b\u5b66\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u6700\u7ec8\u4e3a\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u6709\u610f\u4e49\u7684\u6539\u53d8\u3002&#8221; \u5173\u4e8e\u666e\u9c81\u82cf\u62dc\u5355\u6297 \u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u6297CTLA-4\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\uff08HCAb\uff09\uff0c\u4ea7\u751f\u81ea\u548c\u94c2\u533b\u836f\u4e13\u6709\u7684 Harbour Mice\u00ae\u5e73\u53f0\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u91cd\u94fe\u6297\u4f53\u3002HBM4003\u663e\u793a\u51fa\u589e\u5f3a\u7684ADCC\uff08\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff09\u6d3b\u6027\uff0c\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9ad8\u8868\u8fbeCTLA-4\u7684Treg\u7ec6\u80de\u5177\u6709\u6781\u9ad8\u7684\u7279\u5f02\u6027\u3002\u5176\u5f3a\u6548\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3001\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u6301\u4e45\u7684\u836f\u6548\u5c55\u73b0\u51fa\u826f\u597d\u7684\u4ea7\u54c1\u7279\u6027\uff0c\u8fd9\u79cd\u65b0\u9896\u548c\u5dee\u5f02\u5316\u7684\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u5177\u6709\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u5e76\u663e\u8457\u964d\u4f4e\u836f\u7269\u6bd2\u6027\u7684\u6f5c\u529b\u3002 \u5173\u4e8e\u548c\u94c2\u533b\u836f\u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002\u548c\u94c2\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour Mice\u00ae\u53ef\u751f\u6210\u53cc\u91cd\u3001\u53cc\u8f7b\u94fe\uff08H2L2\uff09\u548c\u4ec5\u91cd\u94fe\uff08HCAb\uff09\u5f62\u5f0f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u57fa\u4e8eHCAb\u6297\u4f53\u5e73\u53f0\u5f00\u53d1\u7684\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\uff08HBICE\u00ae\uff09\u53cc\u6297\u6280\u672f\u80fd\u591f\u5b9e\u73b0\u4f20\u7edf\u836f\u7269\u8054\u5408\u7597\u6cd5\u65e0\u6cd5\u8fbe\u5230\u7684\u6297\u80bf\u7624\u7597\u6548\u3002Harbour Mice\u00ae\uff0cHBICE\u00ae\u4e0e\u5355B\u7ec6\u80de\u514b\u9686\u7b5b\u9009\u5e73\u53f0\u5171\u540c\u7ec4\u6210\u4e86\u548c\u94c2\u7684\u4e0b\u4e00\u4ee3\u521b\u65b0\u6cbb\u7597\u6027\u6297\u4f53\u7814\u53d1\u5f15\u64ce\u3002\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u8bbf\u95ee\uff1awww.harbourbiomed.com\u3002 SOURCE \u548c\u94c2\u533b\u836f","og_url":"https:\/\/moneycompass.com.my\/cn\/\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297pd-1\u6297\u4f53\u6cbb\u7597\/","og_site_name":"Money Compass CN","article_published_time":"2024-10-10T02:57:00+00:00","og_image":[{"width":144,"height":57,"url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/","url":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/","name":"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868 - Money Compass CN","isPartOf":{"@id":"https:\/\/moneycompass.com.my\/cn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#primaryimage"},"image":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#primaryimage"},"thumbnailUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg","datePublished":"2024-10-10T02:57:00+00:00","dateModified":"2024-10-10T02:57:00+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#primaryimage","url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg","contentUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/10\/HB_for_email_Logo-8tjSQM.jpeg","width":144,"height":57},{"@type":"BreadcrumbList","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%88%9b%e6%96%b0%e7%96%97%e6%b3%95%e6%99%ae%e9%b2%81%e8%8b%8f%e6%8b%9c%e5%8d%95%e6%8a%97%e8%81%94%e5%90%88%e6%8a%97pd-1%e6%8a%97%e4%bd%93%e6%b2%bb%e7%96%97\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/moneycompass.com.my\/cn\/"},{"@type":"ListItem","position":2,"name":"\u548c\u94c2\u533b\u836f\u521b\u65b0\u7597\u6cd5\u666e\u9c81\u82cf\u62dc\u5355\u6297\u8054\u5408\u6297PD-1\u6297\u4f53\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868"}]},{"@type":"WebSite","@id":"https:\/\/moneycompass.com.my\/cn\/#website","url":"https:\/\/moneycompass.com.my\/cn\/","name":"Money Compass CN","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/2150"}],"collection":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/comments?post=2150"}],"version-history":[{"count":0,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/2150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media\/2151"}],"wp:attachment":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media?parent=2150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/categories?post=2150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/tags?post=2150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}