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class=\"prnml40\">2025\u5e74\uff0cBRII-179\u5728\u961f\u52174\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u79ef\u6781\u7684\u7ed3\u679c\u3002\u5173\u952e\u6570\u636e\u5df2\u5728\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\uff08APASL\uff09\u5e74\u4f1a\u3001\u6b27\u6d32\u809d\u75c5\u5b66\u4f1a\uff08EASL\uff09\u5e74\u4f1a\u53ca\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\uff08AASLD\uff09\u809d\u75c5\u4f1a\u8bae\u00ae\u7b49\u56fd\u9645\u809d\u75c5\u9886\u57df\u91cd\u8981\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u5e03\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86BRII-179\u5728\u63d0\u5347\u6162\u6027\u4e59\u578b\u809d\u708e\u529f\u80fd\u6027\u6cbb\u6108\u7387\u65b9\u9762\u7684\u6f5c\u529b\u3002<\/p>\n<p class=\"prnml40\">\u5173\u952e\u53d1\u73b0\u5305\u62ec\uff1a<\/p>\n<p class=\"prnml40\">&#8211; BRII-179\u8bf1\u5bfc\u7684\u6297-HBs\u5e94\u7b54\u8005\uff08520 [34-2,165] IU\/mL\uff09\u7684HBsAg\u57fa\u7ebf\u4e2d\u4f4d\u6570[\u8303\u56f4]\u6570\u503c\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\uff08185 [51-672] IU\/mL\uff09\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u5728\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u540e\u7b2c24\u5468\uff0c\u572842.1%\uff088\/19\uff09\u7684BRII-179\u8bf1\u5bfc\u7684\u6297-HBs\u5e94\u7b54\u8005\u4e2d\u89c2\u5bdf\u5230HBsAg\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e2d\u8be5\u6bd4\u4f8b\u4e3a8.3%\uff081\/12\uff09\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u5c3d\u7ba1\u5728ENSURE\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u5b9e\u73b0\u6301\u7eedHBsAg\u6e05\u9664\u7684\u53c2\u4e0e\u8005HBsAg\u57fa\u7ebf\u6c34\u5e73\u5747\u4f4e\u4e8e1,500 IU\/mL\uff0c \u5176\u4e2d50%\uff084\/8\u4f8b\uff09\u6297-HBs\u5e94\u7b54\u8005\u5728\u5148\u524d\u7814\u7a76\u5165\u7ec4\u65f6\u7684HBsAg\u57fa\u7ebf\u6c34\u5e73\u4ecb\u4e8e1,514\u81f33,086 IU\/mL\u4e4b\u95f4\uff0c\u8868\u660eBRII-179\u53ef\u80fd\u5728\u66f4\u5e7f\u6cdb\u7684HBsAg\u57fa\u7ebf\u6c34\u5e73\u8303\u56f4\u5185\u8bf1\u5bfc\u6297-HBs\u5e94\u7b54\u3002<\/p>\n<p class=\"prnml40\">ENSURE\u7814\u7a76\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u516c\u5e03\uff0c\u5e76\u5c06\u5728\u540e\u7eed\u7684\u79d1\u5b66\u4f1a\u8bae\u4e0a\u6c47\u62a5\u3002<\/p>\n<p>\u4e3a\u8fdb\u4e00\u6b65\u660e\u786eBRII-179\u5728HBV\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u786e\u5b9a\u6f5c\u5728\u6ce8\u518c\u6027\u5f00\u53d1\u6240\u9700\u7684\u6700\u4f73\u8054\u5408\u7528\u836f\u65b9\u6848\uff0c\u516c\u53f8\u6b63\u5728\u4e24\u9879\u989d\u5916\u8fdb\u884c\u4e2d\u7684IIb\u671f\u7814\u7a76\u4e2d\u8bc4\u4f30BRII-179\u3002<\/p>\n<p class=\"prnml40\">&#8211; ENRICH\u7814\u7a76\uff1a\u8bc4\u4f30BRII-179\u5728\u6fc0\u6d3bHBV\u7279\u5f02\u6027\u514d\u75ab\u548c\/\u6216\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u53cd\u5e94\u826f\u597d\u3001\u66f4\u53ef\u80fd\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\u7684\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<p class=\"prnml40\">&#8211; ENHANCE\u7814\u7a76\uff1a\u8bc4\u4f30BRII-179\u8054\u5408elebsiran\u4e0ePEG-IFN\u03b1\u7684\u4e09\u8054\u6cbb\u7597\u65b9\u6848\uff0c\u65e8\u5728\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002\u57fa\u4e8eENSURE\u961f\u52174\u7814\u7a76\u7684\u53d1\u73b0\uff0c\u7814\u7a76\u65b9\u6848\u7ecf\u4fee\u8ba2\u540e\u5c06\u8bc4\u4f30\u7b80\u5316\u7248\u4e09\u8054\u6cbb\u7597\u65b9\u6848\uff0c\u8be5\u65b9\u6848\u65e8\u5728\u5c06PEG-IFN\u03b1\u6cbb\u7597\u5468\u671f\u7f29\u77ed\u81f324\u5468\u3002<\/p>\n<p>\u6240\u6709\u7814\u7a76\u76ee\u524d\u5747\u5df2\u5b8c\u6210\u53d7\u8bd5\u8005\u5165\u7ec4\uff0cENRICH\u548cENHANCE\u4e24\u9879\u7814\u7a76\u7684\u6570\u636e\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u4e0b\u534a\u5e74\u516c\u5e03\u3002<\/p>\n<p>\u4e0e\u6b64\u540c\u65f6\uff0c\u516c\u53f8\u5df2\u4e0e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u5c55\u5f00\u6c9f\u901a\uff0c\u5171\u540c\u63a2\u8ba8\u6f5c\u5728\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u53ca\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u3002\u6b63\u5728\u8fdb\u884c\u7684ENRICH\u548cENHANCE\u7814\u7a76\u7ed3\u679c\u5c06\u4e3a\u672a\u6765\u7684\u6ce8\u518c\u6027\u4e34\u5e8a\u5f00\u53d1\u51b3\u7b56\u63d0\u4f9b\u4f9d\u636e\u3002<\/p>\n<p>\u5176\u4ed6\u4e34\u5e8a\u9879\u76ee\u00a0<\/p>\n<p>2025\u5e747\u6708\uff0c\u817e\u76db\u535a\u836f\u5ba3\u5e03\u4e0e\u5065\u5eb7\u5143\u96c6\u56e2\u8fbe\u6210\u6218\u7565\u6388\u6743\u534f\u8bae\uff0c\u6388\u6743\u540e\u8005\u5728\u5927\u4e2d\u534e\u533a\u5f00\u5c55soralimixin\u7684\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u5de5\u4f5c\u3002\u6b64\u6b21\u5408\u4f5c\u5c06\u4f9d\u6258\u5065\u5eb7\u5143\u96c6\u56e2\u5728\u6297\u611f\u67d3\u6cbb\u7597\u9886\u57df\u7684\u6210\u719f\u80fd\u529b\uff0c\u52a0\u901fsoralimixin\u7684\u7814\u53d1\u8fdb\u7a0b\u5e76\u6700\u5927\u5316\u5176\u5546\u4e1a\u6f5c\u529b\u3002\u516c\u53f8\u4fdd\u7559\u5927\u4e2d\u534e\u533a\u4ee5\u5916\u7684\u6743\u76ca\uff0c\u5e76\u5c06\u6301\u7eed\u5bfb\u6c42\u975e\u7a00\u91ca\u6027\u878d\u8d44\u53ca\u62d3\u5c55\u5408\u4f5c\u7684\u673a\u4f1a\u3002\u817e\u76db\u535a\u836f\u6b63\u79ef\u6781\u5bfb\u6c42\u5916\u90e8\u5408\u4f5c\uff0c\u4ee5\u63a8\u8fdb\u5176\u7528\u4e8e\u6cbb\u7597\u548c\u9884\u9632\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u611f\u67d3\uff08HIV\uff09\u7684\u957f\u6548\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316\u8fdb\u7a0b\u3002<\/p>\n<p>\u65e9\u671f\u7814\u53d1\u9879\u76ee\u8fdb\u5c55<\/p>\n<p>\u622a\u81f32025\u5e74\u5e95\uff0c\u817e\u76db\u535a\u836f\u5728\u5317\u4eac\u8fd0\u8425\u4e86\u8f6c\u5316\u7814\u7a76\u5b9e\u9a8c\u5ba4\uff0c\u5728\u4e0a\u6d77\u8bbe\u7acb\u4e86\u914d\u5907\u5c16\u7aef\u8bbe\u5907\u7684\u5168\u6d41\u7a0b\u6574\u5408\u65e9\u7814\u5b9e\u9a8c\u5ba4\uff0c\u5e76\u7ec4\u5efa\u4e86\u884c\u4e1a\u7ecf\u9a8c\u4e30\u5bcc\u7684\u65e9\u7814\u56e2\u961f\u3002\u4f9d\u6258\u8986\u76d6\u4e2d\u7f8e\u4e24\u56fd\u7684\u5168\u7403\u7814\u53d1\u7f51\u7edc\uff0c\u817e\u76db\u535a\u836f\u65e8\u5728\u878d\u5408\u4e2d\u56fd\u672c\u571f\u7814\u53d1\u7684\u521b\u65b0\u80fd\u529b\u4e0e\u6267\u884c\u6548\u7387\uff0c\u4ee5\u53ca\u5168\u7403\u836f\u7269\u53d1\u73b0\u4e0e\u5f00\u53d1\u9886\u57df\u7684\u6df1\u539a\u4e13\u4e1a\u79ef\u6dc0\u3002\u8fd9\u79cd\u8fd0\u8425\u6a21\u5f0f\u80fd\u591f\u5feb\u901f\u5c06\u79d1\u5b66\u53d1\u73b0\u8f6c\u5316\u4e3a\u53ef\u9a8c\u8bc1\u7684\u6cbb\u7597\u5047\u8bbe\uff0c\u9ad8\u6548\u7b5b\u9009\u9776\u70b9\uff0c\u5e76\u63a8\u52a8\u65e9\u671f\u9879\u76ee\u7a33\u6b65\u8de8\u8d8a\u5173\u952e\u5f00\u53d1\u91cc\u7a0b\u7891\u300212\u6708\uff0c\u817e\u76db\u535a\u836f\u5ba3\u5e03\u4e0eOpenBench\u5efa\u7acb\u5408\u4f5c\u5173\u7cfb\uff0c\u501f\u52a9\u5176\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u5e73\u53f0\u52a0\u901f\u516c\u53f8\u7684\u836f\u7269\u53d1\u73b0\u8fdb\u7a0b\u3002\u968f\u7740\u6211\u4eec\u6301\u7eed\u63a8\u8fdb\u76f8\u5173\u9879\u76ee\u8fc8\u5411\u4e34\u5e8a\u9636\u6bb5\uff0c\u9884\u8ba1\u5c06\u57282026\u5e74\u5168\u5e74\u9646\u7eed\u516c\u5e03\u817e\u76db\u535a\u836f\u65e9\u671f\u7814\u53d1\u9879\u76ee\u7684\u66f4\u591a\u8fdb\u5c55\u3002<\/p>\n<p>\u5176\u4ed6\u4f01\u4e1a\u66f4\u65b0<\/p>\n<p>\u4e3a\u8fdb\u4e00\u6b65\u5f3a\u5316\u7ba1\u7406\u5c42\u6fc0\u52b1\u4e0e\u516c\u53f8\u957f\u671f\u80a1\u4e1c\u5229\u76ca\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\uff0c\u8463\u4e8b\u4f1a\u6279\u51c6\u4e86\u5bf92025\u5e74\u548c2026\u5e74\u9ad8\u7ea7\u7ba1\u7406\u5c42\u5e74\u5ea6\u5956\u91d1\u5b89\u6392\u7684\u8c03\u6574\u65b9\u6848\u3002\u6839\u636e\u8be5\u65b9\u6848\uff0c\u5728\u4e0a\u8ff0\u5404\u5e74\uff0c\u516c\u53f8\u56e0\u9ad8\u7ba1\u5e74\u5ea6\u5956\u91d1\u4ea7\u751f\u7684\u85aa\u916c\u603b\u652f\u51fa\u5c06\u5927\u5e45\u51cf\u5c11\uff0c\u964d\u81f3\u539f\u6c34\u5e73\u7684\u7ea6\u56db\u5206\u4e4b\u4e00\u3002\u6b64\u4e3e\u4f53\u73b0\u4e86\u516c\u53f8\u5728\u8d22\u52a1\u7ba1\u7406\u4e0a\u7684\u5ba1\u614e\u6027\uff0c\u5e76\u4f7f\u7ba1\u7406\u5c42\u85aa\u916c\u66f4\u7d27\u5bc6\u5730\u4e0e\u4e1a\u52a1\u8868\u73b0\u3001\u8d44\u672c\u5e02\u573a\u7ed3\u679c\u4ee5\u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IIb 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href=\"https:\/\/www.comein.cn\/roadshow\/home\/475667\" target=\"_blank\" rel=\"noopener\">\u6b64\u5904<\/a>\u3002\u968f\u540e\u5c06\u4e8e3\u670820\u65e5\u665a8:30\uff08\u9999\u6e2f\u65f6\u95f4\uff0c\u5317\u7f8e\u4e1c\u90e8\u65f6\u95f4\u4e0a\u53488:30\uff09\u4e3e\u529e\u82f1\u6587\u573a\uff0c\u6ce8\u518c\u94fe\u63a5\u8bf7\u70b9\u51fb<a href=\"https:\/\/briibio.zoom.us\/webinar\/register\/WN_wcKAx_71Si2IUkiMgv3g0Q\" target=\"_blank\" rel=\"noopener\">\u6b64\u5904<\/a>\u3002<\/p>\n<p>\u6240\u6709\u53c2\u4f1a\u8005\u987b\u5728\u7535\u8bdd\u4f1a\u8bae\u4e4b\u524d\u901a\u8fc7\u4e0a\u8ff0\u94fe\u63a5\u5b8c\u6210\u5728\u7ebf\u6ce8\u518c\u3002\u6ce8\u518c\u540e\uff0c\u6bcf\u4f4d\u53c2\u4f1a\u8005\u5c06\u6536\u5230\u4e00\u5c01\u7535\u5b50\u90ae\u4ef6\uff0c\u5176\u4e2d\u5305\u542b\u6b64\u6b21\u7535\u8bdd\u4f1a\u8bae\u7684\u91cd\u8981\u4fe1\u606f\uff0c\u5305\u62ec\u7535\u8bdd\u4f1a\u8bae\u65e5\u671f\u3001\u65f6\u95f4\u53ca\u8bbf\u95ee\u94fe\u63a5\u3002\u8be5\u94fe\u63a5\u987b\u4e88\u4ee5\u4fdd\u5bc6\uff0c\u4e0d\u5f97\u4e0e\u5176\u4ed6\u53c2\u4f1a\u8005\u5171\u4eab\u3002\u6b64\u5916\uff0c\u6b64\u7535\u8bdd\u4f1a\u8bae\u7684\u56de\u653e\u5c06\u5728\u4f1a\u8bae\u540e\u63d0\u4f9b\uff0c\u5e76\u53ef\u901a\u8fc7\u8bbf\u95ee\u672c\u516c\u53f8\u7f51\u7ad9<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"noopener\">www.briibio.com<\/a>\u7684\u6295\u8d44\u8005\u5173\u7cfb\u7248\u5757\u83b7\u53d6\u3002<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6d89\u53ca\u7b2c\u4e09\u65b9\u4fe1\u606f\u7684\u5f15\u7528\u3002\u6b64\u7c7b\u4fe1\u606f\u4e0d\u5e94\u88ab\u89c6\u4e3a\u53c2\u8003\u4fe1\u606f\u7eb3\u5165\u672c\u65b0\u95fb\u7a3f\u4e2d\u3002\u817e\u76db\u535a\u836f\u5bf9\u6b64\u7c7b\u7b2c\u4e09\u65b9\u4fe1\u606f\u7684\u4e0d\u8d1f\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<p>\u5173\u4e8e\u817e\u76db\u535a\u836f\u00a0<\/p>\n<p>\u817e\u76db\u535a\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u91cd\u5927\u672a\u88ab\u6ee1\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7597\u9009\u62e9\u6709\u9650\u7684\u9886\u57df\u5f00\u53d1\u7597\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u3002\u516c\u53f8\u6b63\u63a8\u8fdb\u4e00\u7cfb\u5217\u72ec\u7279\u7684\u5019\u9009\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\uff0c\u5305\u62ec\u8fdb\u5c55\u6700\u9886\u5148\u7684\u9488\u5bf9\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9879\u76ee\u3002\u5728\u5bcc\u6709\u8fdc\u89c1\u5353\u8bc6\u548c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u9886\u5bfc\u56e2\u961f\u5e26\u9886\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u4e8e\u7f57\u5229-\u8fbe\u52d2\u59c6\u3001\u65e7\u91d1\u5c71\u6e7e\u533a\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u672f\u4e2d\u5fc3\u5f00\u5c55\u4e1a\u52a1\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u00a0<a 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2025\u5e74\u5bf9\u817e\u76db\u535a\u836f\u800c\u8a00\u662f\u6267\u884c\u529b\u7a81\u51fa\u3001\u6218\u7565\u63a8\u8fdb\u663e\u8457\u7684\u4e00\u5e74\uff0c\u5176\u540e\u671f\u4e34\u5e8a\u9636\u6bb5\u7684\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u4ea7\u54c1\u7ec4\u5408\u6301\u7eed\u63a8\u8fdb\u4ee5\u5b9e\u73b0\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002\u516c\u53f8\u5728\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\uff08AASLD\uff09\u809d\u75c5\u4f1a\u8bae\u00ae\u4e0a\u516c\u5e03\u4e86\u6b63\u5728\u8fdb\u884c\u7684ENSURE IIb\u671f\u7814\u7a76\u961f\u52174\u6cbb\u7597\u7ed3\u675f\u540e24\u5468\u968f\u8bbf\u6570\u636e\uff0c\u8be5\u6210\u679c\u540c\u6b65\u53d1\u8868\u4e8e\u300a\u81ea\u7136-\u533b\u5b66\u300b\u3002\u8fd9\u4e9b\u7ed3\u679c\u652f\u6301\u4e86BRII-179\u5177\u6709\u5728\u4e0d\u540c\u60a3\u8005\u7fa4\u4f53\u4e2d\u63d0\u5347\u529f\u80fd\u6027\u6cbb\u6108\u6548\u679c\u7684\u6f5c\u529b\u3002\u57fa\u4e8eENSURE\u961f\u52174\u7814\u7a76\u7684\u53d1\u73b0\uff0c\u817e\u76db\u535a\u836f\u4fee\u8ba2\u4e86ENHANCE\u7814\u7a76\u65b9\u6848\uff0c\u4ee5\u8bc4\u4f30\u66ff\u4ee3\u6027\u4e09\u8054\u7597\u6cd5\u2014\u2014\u8be5\u65b9\u6848\u65e8\u5728\u7ef4\u6301\u7597\u6548\u7684\u540c\u65f6\u7f29\u77ed\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u6cbb\u7597\u5468\u671f\u3002\u786e\u8bc1\u6027IIb\u671fENRICH\u4e0eENHANCE\u7814\u7a76\u73b0\u5df2\u5b8c\u6210\u60a3\u8005\u62db\u52df\uff0c\u7ed3\u679c\u9884\u8ba1\u4e8e2026\u5e74\u4e0b\u534a\u5e74\u516c\u5e03\u3002 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Johns\u535a\u58eb\u7684\u9886\u5bfc\u4e0b\uff0c\u8fdb\u4e00\u6b65\u62d3\u5c55\u4e86\u836f\u7269\u65e9\u671f\u7814\u53d1\u5de5\u4f5c\u3002\u4f9d\u6258\u7ecf\u9a8c\u4e30\u5bcc\u7684\u65e9\u7814\u56e2\u961f\uff0c\u516c\u53f8\u5728\u5317\u4eac\u548c\u4e0a\u6d77\u4e24\u5730\u8bbe\u7acb\u5b9e\u9a8c\u5ba4\uff0c\u6784\u5efa\u4e86\u5f3a\u5927\u7684\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u3002\u540c\u65f6\u5145\u5206\u5229\u7528\u4e2d\u56fd\u517c\u5177\u521b\u65b0\u548c\u6267\u884c\u6548\u7387\u7684\u5f3a\u5927\u836f\u7269\u7814\u53d1\u751f\u6001\uff0c\u63a8\u52a8\u516c\u53f8\u65e9\u671f\u7814\u53d1\u7ba1\u7ebf\u8fdb\u5c55\uff0c\u4ece\u800c\u521b\u9020\u957f\u671f\u4ef7\u503c\u3002\u516c\u53f8\u8ba1\u5212\u4e8e\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u62ab\u9732\u66f4\u591a\u5173\u4e8e\u5176\u65e9\u671f\u7814\u53d1\u6218\u7565\u548c\u7ba1\u7ebf\u7684\u8be6\u7ec6\u4fe1\u606f\u3002 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ENSURE\u7814\u7a76\u76842b\u671f\u8bbe\u8ba1\u65e8\u5728\u8bc4\u4f30\u6539\u5584\u529f\u80fd\u6027\u6cbb\u6108\u7ed3\u679c\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u961f\u52171-3\u8bc4\u4f30elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u4e0ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u7597\u6548\u5bf9\u6bd4\uff0c\u961f\u52174\u5219\u8bc4\u4f30BRII-179\u5728\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u60a3\u8005\u53ca\u63d0\u9ad8\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5c\u5728\u4f5c\u7528\u3002 2025\u5e74\uff0cBRII-179\u5728\u961f\u52174\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u79ef\u6781\u7684\u7ed3\u679c\u3002\u5173\u952e\u6570\u636e\u5df2\u5728\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\uff08APASL\uff09\u5e74\u4f1a\u3001\u6b27\u6d32\u809d\u75c5\u5b66\u4f1a\uff08EASL\uff09\u5e74\u4f1a\u53ca\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\uff08AASLD\uff09\u809d\u75c5\u4f1a\u8bae\u00ae\u7b49\u56fd\u9645\u809d\u75c5\u9886\u57df\u91cd\u8981\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u5e03\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86BRII-179\u5728\u63d0\u5347\u6162\u6027\u4e59\u578b\u809d\u708e\u529f\u80fd\u6027\u6cbb\u6108\u7387\u65b9\u9762\u7684\u6f5c\u529b\u3002 \u5173\u952e\u53d1\u73b0\u5305\u62ec\uff1a &#8211; BRII-179\u8bf1\u5bfc\u7684\u6297-HBs\u5e94\u7b54\u8005\uff08520 [34-2,165] IU\/mL\uff09\u7684HBsAg\u57fa\u7ebf\u4e2d\u4f4d\u6570[\u8303\u56f4]\u6570\u503c\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\uff08185 [51-672] IU\/mL\uff09\u3002 &#8211; 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ENSURE\u7814\u7a76\u76842b\u671f\u8bbe\u8ba1\u65e8\u5728\u8bc4\u4f30\u6539\u5584\u529f\u80fd\u6027\u6cbb\u6108\u7ed3\u679c\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u961f\u52171-3\u8bc4\u4f30elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u4e0ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u7597\u6548\u5bf9\u6bd4\uff0c\u961f\u52174\u5219\u8bc4\u4f30BRII-179\u5728\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u60a3\u8005\u53ca\u63d0\u9ad8\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5c\u5728\u4f5c\u7528\u3002 2025\u5e74\uff0cBRII-179\u5728\u961f\u52174\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u79ef\u6781\u7684\u7ed3\u679c\u3002\u5173\u952e\u6570\u636e\u5df2\u5728\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\uff08APASL\uff09\u5e74\u4f1a\u3001\u6b27\u6d32\u809d\u75c5\u5b66\u4f1a\uff08EASL\uff09\u5e74\u4f1a\u53ca\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\uff08AASLD\uff09\u809d\u75c5\u4f1a\u8bae\u00ae\u7b49\u56fd\u9645\u809d\u75c5\u9886\u57df\u91cd\u8981\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u5e03\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86BRII-179\u5728\u63d0\u5347\u6162\u6027\u4e59\u578b\u809d\u708e\u529f\u80fd\u6027\u6cbb\u6108\u7387\u65b9\u9762\u7684\u6f5c\u529b\u3002 \u5173\u952e\u53d1\u73b0\u5305\u62ec\uff1a &#8211; BRII-179\u8bf1\u5bfc\u7684\u6297-HBs\u5e94\u7b54\u8005\uff08520 [34-2,165] IU\/mL\uff09\u7684HBsAg\u57fa\u7ebf\u4e2d\u4f4d\u6570[\u8303\u56f4]\u6570\u503c\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\uff08185 [51-672] IU\/mL\uff09\u3002 &#8211; \u5728\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u540e\u7b2c24\u5468\uff0c\u572842.1%\uff088\/19\uff09\u7684BRII-179\u8bf1\u5bfc\u7684\u6297-HBs\u5e94\u7b54\u8005\u4e2d\u89c2\u5bdf\u5230HBsAg\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u4e2d\u8be5\u6bd4\u4f8b\u4e3a8.3%\uff081\/12\uff09\u3002 &#8211; \u5c3d\u7ba1\u5728ENSURE\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u5b9e\u73b0\u6301\u7eedHBsAg\u6e05\u9664\u7684\u53c2\u4e0e\u8005HBsAg\u57fa\u7ebf\u6c34\u5e73\u5747\u4f4e\u4e8e1,500 IU\/mL\uff0c \u5176\u4e2d50%\uff084\/8\u4f8b\uff09\u6297-HBs\u5e94\u7b54\u8005\u5728\u5148\u524d\u7814\u7a76\u5165\u7ec4\u65f6\u7684HBsAg\u57fa\u7ebf\u6c34\u5e73\u4ecb\u4e8e1,514\u81f33,086 IU\/mL\u4e4b\u95f4\uff0c\u8868\u660eBRII-179\u53ef\u80fd\u5728\u66f4\u5e7f\u6cdb\u7684HBsAg\u57fa\u7ebf\u6c34\u5e73\u8303\u56f4\u5185\u8bf1\u5bfc\u6297-HBs\u5e94\u7b54\u3002 ENSURE\u7814\u7a76\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u4e0a\u534a\u5e74\u516c\u5e03\uff0c\u5e76\u5c06\u5728\u540e\u7eed\u7684\u79d1\u5b66\u4f1a\u8bae\u4e0a\u6c47\u62a5\u3002 \u4e3a\u8fdb\u4e00\u6b65\u660e\u786eBRII-179\u5728HBV\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u786e\u5b9a\u6f5c\u5728\u6ce8\u518c\u6027\u5f00\u53d1\u6240\u9700\u7684\u6700\u4f73\u8054\u5408\u7528\u836f\u65b9\u6848\uff0c\u516c\u53f8\u6b63\u5728\u4e24\u9879\u989d\u5916\u8fdb\u884c\u4e2d\u7684IIb\u671f\u7814\u7a76\u4e2d\u8bc4\u4f30BRII-179\u3002 &#8211; ENRICH\u7814\u7a76\uff1a\u8bc4\u4f30BRII-179\u5728\u6fc0\u6d3bHBV\u7279\u5f02\u6027\u514d\u75ab\u548c\/\u6216\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u53cd\u5e94\u826f\u597d\u3001\u66f4\u53ef\u80fd\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\u7684\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002 &#8211; 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