{"id":2407,"date":"2024-10-16T07:37:00","date_gmt":"2024-10-16T07:37:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e6%b3%b0%e7%91%9e%e6%b2%99%e5%92%8c%e6%b2%83%e7%91%9e%e6%b2%99%e7%9a%84%e8%81%94%e5%90%88%e7%96%97%e6%b3%95%e5%9c%a8savannah-ii\/"},"modified":"2024-10-16T07:37:00","modified_gmt":"2024-10-16T07:37:00","slug":"%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e6%b3%b0%e7%91%9e%e6%b2%99%e5%92%8c%e6%b2%83%e7%91%9e%e6%b2%99%e7%9a%84%e8%81%94%e5%90%88%e7%96%97%e6%b3%95%e5%9c%a8savannah-ii","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e6%b3%b0%e7%91%9e%e6%b2%99%e5%92%8c%e6%b2%83%e7%91%9e%e6%b2%99%e7%9a%84%e8%81%94%e5%90%88%e7%96%97%e6%b3%95%e5%9c%a8savannah-ii\/","title":{"rendered":"\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u6cf0\u745e\u6c99\u00ae\u548c\u6c83\u745e\u6c99\u00ae\u7684\u8054\u5408\u7597\u6cd5\u5728SAVANNAH II\u671f\u7814\u7a76\u4e2d\u5728\u4f34\u6709\u9ad8MET\u6c34\u5e73\u7684\u80ba\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u9ad8\u4e14\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u7f13\u89e3\u7387"},"content":{"rendered":"

\u2014 \u65b0\u7684\u6570\u636e\u663e\u793a\u8be5\u53e3\u670d\u8054\u5408\u7597\u6cd5\u5728EGFR \u7a81\u53d8\u80ba\u764c\u4e2d\u5bf9MET\u9a71\u52a8\u8010\u836f\u6027\u7684\u7597\u6548 \u2014
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\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

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MET\u662f\u4e00\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5728\u7ec6\u80de\u7684\u6b63\u5e38\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u53ef\u5bfc\u81f4\u80bf\u7624\u751f\u957f\u4ee5\u53ca\u764c\u7ec6\u80de\u7684\u8f6c\u79fb\u8fdb\u5c55\uff0c\u4e14\u662fEGFR\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5bf9EGFR TKI\u6cbb\u7597\u4ea7\u751f\u83b7\u5f97\u6027\u8010\u836f\u7684\u4e3b\u8981\u673a\u5236\u4e4b\u4e00\u3002\u5728\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u7ea6\u6709\u00a015-50% \u51fa\u73b0\u00a0MET \u5f02\u5e38\u3002[9],[10],[11],[12],[13]\u00a0 MET\u6269\u589e\u548c\u8fc7\u8868\u8fbe\u7684\u53d1\u751f\u7387\u53ef\u80fd\u56e0\u6837\u54c1\u7c7b\u578b\u3001\u68c0\u6d4b\u65b9\u6cd5\u548c\u4f7f\u7528\u7684\u6d4b\u5b9a\u9608\u503c\u800c\u5f02\u3002[14]<\/p>\n

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SAVANNAH\u7814\u7a76\u662f\u4e00\u9879\u7531\u963f\u65af\u5229\u5eb7\u7533\u529e\u7684\u6b63\u5728\u8fdb\u884c\u4e2d\u7684\u968f\u673a\u3001\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u6c83\u745e\u6c99\u00ae<\/span>\u4e0e\u6cf0\u745e\u6c99\u00ae<\/span>\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u65e2\u5f80\u66fe\u63a5\u53d7\u6cf0\u745e\u6c99\u00ae<\/span>\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684EGFR\u7a81\u53d8\u3001MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u6839\u636e\u6700\u521d\u7684\u5355\u81c2\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u60a3\u8005\u6309300\u6beb\u514b\u6216600\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\uff0c\u6216300\u6beb\u514b\u6bcf\u65e5\u4e24\u6b21\u7684\u5242\u91cf\u63a5\u53d7\u6c83\u745e\u6c99\u00ae<\/span>\u7ed9\u836f\u6cbb\u7597\uff0c\u8054\u5408\u6cf0\u745e\u6c99\u00ae<\/span>80\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\u7684\u5242\u91cf\u6cbb\u7597\u30022022 \u5e74\uff0c\u7814\u7a76\u589e\u52a0\u4e86\u6ce8\u518c\u90e8\u5206\uff0c\u4f7f\u7528\u6c83\u745e\u6c99\u00ae<\/span>300\u6beb\u514b\u6bcf\u65e5\u4e24\u6b21\u8054\u5408\u6cf0\u745e\u6c99\u00ae<\/span>80\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\uff0c\u5bf9\u6bd4\u6c83\u745e\u6c99\u00ae300\u6beb\u514b\u6bcf\u65e5\u4e24\u6b21\u52a0\u5b89\u6170\u5242\u3002<\/p>\n

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\n

[1]\u00a0\u00a0 Del Re M, et al. Understanding the Mechanisms of Resistance in EGFR-Positive NSCLC: From Tissue to Liquid Biopsy to Guide Treatment Strategy. Int J Mol Sci. 2019;20(16): 3951.<\/span><\/p>\n

[2]\u00a0\u00a0 World Health Organization. International Agency for Research on Cancer. Lung Fact Sheet. Available at: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/15-trachea-bronchus-and-lung-fact-sheet.pdf<\/a>. Accessed September 2024.<\/span><\/p>\n

[3]World Health Organization. International Agency for Research on Cancer. World Fact Sheet. Available at: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/900-world-fact-sheet.pdf<\/a>. Accessed October 2024.<\/span><\/p>\n

[4]\u00a0\u00a0 LUNGevity Foundation. Types of Lung Cancer. Available at: https:\/\/lungevity.org\/for-patients-caregivers\/lung-cancer-101\/types-of-lung-cancer<\/a>. Accessed September 2024.<\/span><\/p>\n

[5]\u00a0\u00a0 Cheema PK, et al. Perspectives on treatment advances for stage III locally advanced unresectable non-small-cell lung cancer. Curr Oncol. 2019;26(1):37-42.<\/span><\/p>\n

[6]\u00a0\u00a0 Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27.<\/span><\/p>\n

[7]\u00a0\u00a0 Szumera-Cie\u0107kiewicz A, et al.\u202fEGFR Mutation Testing on Cytological and Histological Samples in 11. Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence.\u202fInt J Clin Exp Pathol. 2013:6;2800-12.<\/span><\/p>\n

[8]\u00a0\u00a0 Ellison G, et al. EGFR Mutation Testing in Lung Cancer: a Review of Available Methods and Their Use for Analysis of Tumour Tissue and Cytology Samples. J Clin Pathol. 2013;66:79-89.<\/span><\/p>\n

[9]\u00a0\u00a0 Soria JC, et al. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(2):113-125.<\/span><\/p>\n

[10]\u00a0Mok TS, et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017;376(7):629-640.<\/span><\/p>\n

[11]\u00a0Hartmaier R, et al. Tumor genomics in patients (pts) with advanced epidermal growth factor receptor mutant (EGFRm) non-small cell lung cancer (NSCLC) whose disease has progressed on first-line (1L) osimertinib therapy in the Phase II ORCHARD study. Cancer Res\u00a015 June 2022; 82 (12_Supplement):\u00a0LB078.<\/span><\/p>\n

[12]\u00a0Piotrowska, et al.\u00a0 MET amplification (amp) as a resistance mechanism to osimertinib. Journal of Clinical Oncology 2017 35:15_suppl, 9020-9020.\u00a0<\/span><\/p>\n

[13]\u00a0Hartmaier, et al. Detection of MET-mediated EGFR tyrosine kinase inhibitor (TKI) resistance in advanced non-small cell lung cancer (NSCLC): biomarker analysis of the TATTON study. Cancer Res (2019) 79 (13_Supplement): 4897.<\/span><\/p>\n

[14]\u00a0Coleman N, et al. Beyond epidermal growth factor receptor: MET amplification as a general resistance driver to targeted therapy in oncogene-driven non-small-cell lung cancer. ESMO Open. 2019;6(6).<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

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href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u6cf0\u745e\u6c99\u548c\u6c83\u745e\u6c99\u7684\u8054\u5408\u7597\u6cd5\u5728savannah-ii\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u6cf0\u745e\u6c99\u00ae\u548c\u6c83\u745e\u6c99\u00ae\u7684\u8054\u5408\u7597\u6cd5\u5728SAVANNAH II\u671f\u7814\u7a76\u4e2d\u5728\u4f34\u6709\u9ad8MET\u6c34\u5e73\u7684\u80ba\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u9ad8\u4e14\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u7f13\u89e3\u7387 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u2014 \u65b0\u7684\u6570\u636e\u663e\u793a\u8be5\u53e3\u670d\u8054\u5408\u7597\u6cd5\u5728EGFR \u7a81\u53d8\u80ba\u764c\u4e2d\u5bf9MET\u9a71\u52a8\u8010\u836f\u6027\u7684\u7597\u6548 \u2014\u2014 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