{"id":24764,"date":"2026-06-02T06:55:00","date_gmt":"2026-06-02T06:55:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e6%99%b6%e6%b3%b0%e7%a7%91%e6%8a%80%e8%b5%8b%e8%83%bd%e5%b8%8c%e6%a0%bc%e7%94%9f%e7%a7%91%e5%86%8d%e8%8e%b7ind%ef%bc%9a%e5%bc%ba%e6%b4%bb%e6%80%a7-pan-tead%e6%8a%91%e5%88%b6%e5%89%82sigx2649%e4%b8%b4\/"},"modified":"2026-06-02T06:55:00","modified_gmt":"2026-06-02T06:55:00","slug":"%e6%99%b6%e6%b3%b0%e7%a7%91%e6%8a%80%e8%b5%8b%e8%83%bd%e5%b8%8c%e6%a0%bc%e7%94%9f%e7%a7%91%e5%86%8d%e8%8e%b7ind%ef%bc%9a%e5%bc%ba%e6%b4%bb%e6%80%a7-pan-tead%e6%8a%91%e5%88%b6%e5%89%82sigx2649%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e6%99%b6%e6%b3%b0%e7%a7%91%e6%8a%80%e8%b5%8b%e8%83%bd%e5%b8%8c%e6%a0%bc%e7%94%9f%e7%a7%91%e5%86%8d%e8%8e%b7ind%ef%bc%9a%e5%bc%ba%e6%b4%bb%e6%80%a7-pan-tead%e6%8a%91%e5%88%b6%e5%89%82sigx2649%e4%b8%b4\/","title":{"rendered":"\u6676\u6cf0\u79d1\u6280\u8d4b\u80fd\u5e0c\u683c\u751f\u79d1\u518d\u83b7IND\uff1a\u5f3a\u6d3b\u6027 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                \n                <\/p>\n<\/div>\n<p>\u6b64\u6b21 SIGX2649 \u63d0\u524d IND \u83b7\u6279\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u8be5\u7ba1\u7ebf\u7684\u4e34\u5e8a\u6025\u9700\u6027\u3002\u5176\u6838\u5fc3\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u5c55\u73b0\u51fa\u4f18\u5f02\u7684\u6210\u836f\u6027\u3001\u5b89\u5168\u6027\u4e0e\u5dee\u5f02\u5316\u7684\u4e34\u5e8a\u4ef7\u503c\u3002\u540c\u65f6\uff0c\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\u9996\u5e2d\u4e13\u5bb6\u3001\u4e2d\u56fd\u80ba\u764c\u7cbe\u51c6\u6cbb\u7597\u9886\u519b\u4eba\u7269\u5434\u4e00\u9f99\u6559\u6388\u5c06\u6b63\u5f0f\u62c5\u4efb SIGX2649 \u7684 I \u671f\u4e34\u5e8a\uff0c\u548c SIGX1094 \u8054\u5408 KRAS-G12C \u6291\u5236\u5242 I\/II \u671f\u4e34\u5e8a\u7684\u9996\u5e2d\u7814\u7a76\u8005\uff08Leading PI\uff09\uff0c\u52a0\u901f\u63a8\u8fdb\u4e24\u5927\u6838\u5fc3\u7ba1\u7ebf\u7684\u5168\u7403\u5f00\u53d1\u3002<\/p>\n<p>\u6676\u6cf0\u79d1\u6280\u4e0e\u5e0c\u683c\u751f\u79d1\u591a\u4e2a\u5728\u7814\u7ba1\u7ebf\u7684\u8fde\u7eed\u6210\u529f\uff0c\u6709\u529b\u5370\u8bc1\u4e86\u5176\u5e95\u5c42\u7814\u53d1\u5e73\u53f0 &#8220;\u4ece\u7b97\u6cd5\u5230\u4e34\u5e8a&#8221; \u7684\u5feb\u901f\u8f6c\u5316\u80fd\u529b\uff0c\u4ee5\u53ca &#8220;AI+\u7c7b\u5668\u5b98&#8221; \u6a21\u5f0f\u5728\u653b\u575a\u9ad8\u4ef7\u503c\u3001\u521b\u65b0\u9776\u70b9\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5de8\u5927\u6f5c\u529b\u3002\u6839\u636e\u53cc\u65b9\u534f\u8bae\uff0c\u6676\u6cf0\u79d1\u6280\u6709\u6743\u83b7\u5f97 SIGX2649 \u6700\u9ad8\u8fbe\u4e24\u4f4d\u6570\u6bd4\u4f8b\u7684\u5546\u4e1a\u5316\u6536\u76ca\u5206\u6210\u3002<\/p>\n<p>TEAD \u86cb\u767d\u662f Hippo \u4fe1\u53f7\u901a\u8def\u7684\u6838\u5fc3\u8282\u70b9\uff0c\u8be5\u901a\u8def\u4e0e P53\u3001RAS \u7b49\u5e76\u5217\u4e3a\u6838\u5fc3\u80bf\u7624\u9a71\u52a8\u901a\u8def\uff0c\u5728\u95f4\u76ae\u7624\u3001\u809d\u764c\u3001\u80ba\u764c\u7b49\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u5e7f\u9614\u524d\u666f\uff0c\u4f46\u957f\u671f\u7f3a\u4e4f\u6709\u6548\u836f\u7269\u3002TEAD \u86cb\u767d\u5bb6\u65cf\u5b58\u5728\u56db\u79cd\u529f\u80fd\u4e0e\u8868\u8fbe\u6a21\u5f0f\u5404\u5f02\u7684\u4e9a\u578b\uff0c\u5176\u6291\u5236\u5242\u9700\u5728\u5f3a\u6548\u6291\u5236\u5404\u4e9a\u578b\u4e0e\u5b89\u5168\u6027\u4e4b\u95f4\u53d6\u5f97\u5e73\u8861\uff0c\u6781\u5177\u6311\u6218\u6027\u3002\u76ee\u524d\u5168\u7403\u8303\u56f4\u5185\u5c1a\u65e0 TEAD \u6291\u5236\u5242\u83b7\u6279\u4e0a\u5e02\uff0c\u6700\u5feb\u5728\u7814\u4ea7\u54c1\u4ea6\u5904\u4e8e I \u671f\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n<p>SIGX2649 \u662f\u6676\u6cf0\u79d1\u6280\u4e0e\u5e0c\u683c\u751f\u79d1\u57fa\u4e8e\u00a0&#8220;AI+\u7c7b\u5668\u5b98&#8221;\u00a0\u6a21\u5f0f\u5408\u4f5c\u7814\u53d1\u7684\u6cdb TEAD\uff08TEAD 1-4\uff09\u6291\u5236\u5242\uff0c\u53ef\u540c\u65f6\u9776\u5411 TEAD \u5bb6\u65cf\u5168\u90e8 4 \u79cd\u4e9a\u578b\uff0c\u5c55\u73b0\u51fa\u5e7f\u9614\u7684\u4e34\u5e8a\u5f00\u53d1\u524d\u666f\u3002\u5176\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff0c\u5728\u6291\u5236 TEAD \u68d5\u6988\u9170\u5316\u7684\u540c\u65f6\u589e\u5f3a VGLL4 \u4e0e TEAD \u7684\u7ed3\u5408\uff0c\u80fd\u8fdb\u4e00\u6b65\u653e\u5927\u8be5\u836f\u5bf9 YAP\/TEAD \u529f\u80fd\u7684\u6291\u5236\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0cSIGX2649 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