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\u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u6e56\u5dde<\/span>2026\u5e746\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u5317\u4eac\u65f6\u95f42026\u5e745\u670831\u65e5\uff0c\u5168\u7403\u80bf\u7624\u9886\u57df\u5e74\u5ea6\u76db\u4f1a2026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u5728\u829d\u52a0\u54e5\u76db\u5927\u53ec\u5f00\u3002\u6e2f\u80a1\u521b\u65b0\u836f\u4f01\u540c\u6e90\u5eb7\u533b\u836f\uff0802410.HK\uff09\u81ea\u4e3b\u7814\u53d1\u7684\u7532\u78fa\u9178\u827e\u591a\u66ff\u5c3c\u7247\uff08TY-9591\uff09\u5bf9\u6bd4\u5965\u5e0c\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u5173\u952eII\u671fESAONA\u7814\u7a76\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff08LBA\uff09\u7684\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u5728\u6b64\u6b21ASCO\u4e0a\u8fdb\u884c\u91cd\u78c5\u53d1\u5e03\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u827e\u591a\u66ff\u5c3c\u5728\u9885\u5185\u7597\u6548\u3001\u5168\u8eab\u6297\u80bf\u7624\u7597\u6548\u4e24\u5927\u7ef4\u5ea6\u6709\u663e\u8457\u4f18\u52bf<\/span>\uff0c\u4e14\u83b7\u76ca\u4f18\u52bf\u8d2f\u7a7f\u6240\u6709\u4e9a\u7ec4\uff0c\u5c55\u73b0\u51fa\u540c\u7c7b\u6700\u4f18\u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n

\u827e\u591a\u66ff\u5c3c\u4e34\u5e8a\u6570\u636e\u8fc5\u901f\u83b7\u5f97\u4e86\u6d77\u5185\u5916\u80bf\u7624\u4e13\u5bb6\u3001\u4ea7\u4e1a\u754c\u53ca\u8d44\u672c\u5e02\u573a\u7684\u9ad8\u5ea6\u5173\u6ce8\uff0c\u8be5\u6210\u679c\u4e0d\u4ec5\u6807\u5fd7\u7740\u56fd\u4ea7\u521b\u65b0\u836f\u5728\u96be\u6cbb\u7684\u80ba\u764c\u8111\u8f6c\u79fb\u6cbb\u7597\u9886\u57df\u5b9e\u73b0\u4e86\u91cc\u7a0b\u7891\u5f0f\u7684\u8de8\u8d8a\uff0c\u8fdb\u4e00\u6b65\u5f70\u663e\u4e86\u56fd\u5185\u836f\u4f01\u7684\u521b\u65b0\u5b9e\u529b\uff0c\u4e5f\u4e3aNSCLC\u8111\u8f6c\u79fb\u60a3\u8005\u5e26\u6765\u4e86\u5168\u65b0\u7684\u6cbb\u7597\u8def\u5f84\u3002<\/p>\n

\u9885\u5185\u3001\u5168\u8eab\u7597\u6548\u53cc\u53cc\u4f18\u6548\uff0c\u5c55\u73b0\u51fa\u540c\u7c7b\u6700\u4f18\u6f5c\u8d28<\/p>\n

\u6b64\u6b21\u5728ASCO\u4e0a\u53d1\u5e03\u7684ESAONA\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u7684\u5173\u952eII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u5168\u7403\u4e00\u7ebf\u6807\u51c6\u7597\u6cd5\u5965\u5e0c\u66ff\u5c3c\u4e3a\u5bf9\u7167\uff0c\u65e8\u5728\u5168\u9762\u9a8c\u8bc1\u827e\u591a\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597EGFR\u7ecf\u5178\u7a81\u53d8NSCLC\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u7531\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u77f3\u8fdc\u51ef\u6559\u6388\u7275\u5934\uff0c\u5168\u56fd50\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u53c2\u52a0\u3002<\/p>\n

\u622a\u81f32025\u5e7412\u670815\u65e5\uff08\u672c\u6b21\u6570\u636e\u5206\u6790\u65f6\u95f4\uff09\uff0c\u7814\u7a76\u5171\u7eb3\u5165224\u4f8b\u53d7\u8bd5\u8005\uff0c\u827e\u591a\u66ff\u5c3c\u7ec4111\u4f8b\uff0c\u5965\u5e0c\u66ff\u5c3c\u7ec4113\u4f8b\uff0c\u5206\u522b\u63a5\u53d7\u827e\u591a\u66ff\u5c3c160mg\u6bcf\u65e5\u4e00\u6b21\u3001\u5965\u5e0c\u66ff\u5c3c 80mg\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7597\uff0c\u5e76\u4f9d\u636eEGFR\u7a81\u53d8\u4e9a\u578b\uff0819Del\u6216L858R\uff09\u3001\u9885\u5185\u75c5\u7076\u6570\u91cf\uff08\uff1e3\u6216\u22643\uff09\u8fdb\u884c\u5206\u5c42\uff0c\u4e25\u683c\u786e\u4fdd\u4e24\u7ec4\u57fa\u7ebf\u6570\u636e\u5747\u8861\u53ef\u6bd4\u3002\u7814\u7a76\u4ee5\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u4f30\uff08BICR\uff09\u7684\u9885\u5185\u5ba2\u89c2\u7f13\u89e3\u7387\uff08iORR\uff09\u3001\u9885\u5185\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08iPFS\uff09\u4e3a\u4e3b\u8981\u7ec8\u70b9\uff0c\u4ece\u9885\u5185\u7597\u6548\u3001\u5168\u8eab\u6297\u80bf\u7624\u7597\u6548\u3001\u5b89\u5168\u6027\u7b49\u591a\u7ef4\u5ea6\u8fdb\u884c\u4e86\u5168\u9762\u8bc4\u4f30\u3002<\/p>\n

\u671f\u4e2d\u5206\u6790\u6570\u636e\u663e\u793a\uff0c\u5728\u4e2d\u4f4d\u968f\u8bbf19.12\u4e2a\u6708\u7684\u8282\u70b9\uff0c\u5728\u6700\u53d7\u5173\u6ce8\u7684\u9885\u5185\u7597\u6548\u4e0a\uff0c\u7ecfBICR\u6743\u5a01\u8bc4\u4f30\uff0c\u827e\u591a\u66ff\u5c3c\u7ec4\u9885\u5185\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a95.5%\uff0c\u5965\u5e0c\u66ff\u5c3c\u7ec4\u4e3a<\/span>79.6%\uff0c\u7edf\u8ba1\u5b66\u5dee\u5f02\u6781\u5177\u663e\u8457\u6027\uff08P=0.0004\uff09\uff0c\u4e14\u8fd9\u4e00\u663e\u8457\u83b7\u76ca\u4f18\u52bf\u8986\u76d6\u6240\u6709\u9884\u8bbe\u4e9a\u7ec4\uff0c\u5728\u9884\u5148\u8bbe\u5b9a\u7684\u5206\u5c42\u56e0\u7d20\u6240\u5b9a\u4e49\u7684\u6240\u6709\u4e9a\u7ec4\u4e2d\uff0c\u5747\u80fd\u4ece\u827e\u591a\u66ff\u5c3c\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002<\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u5728\u9885\u5185\u957f\u671f\u751f\u5b58\u83b7\u76ca\u65b9\u9762\uff0c\u827e\u591a\u66ff\u5c3c\u7ec4\u4e2d\u4f4d\u9885\u5185\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08iPFS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c\u5965\u5e0c\u66ff\u5c3c\u7ec4\u4e3a17.51\u4e2a\u6708<\/span>\uff0c\u98ce\u9669\u6bd4HR=0.46\uff08P=0.0020\uff09\u3002\u540c\u65f6\uff0c\u957f\u671f\u968f\u8bbf\u6570\u636e\u8fd8\u663e\u793a\uff0c\u827e\u591a\u66ff\u5c3c\u7ec418\u4e2a\u6708\u300124\u4e2a\u6708iPFS\u7387\u5206\u522b\u8fbe\u523075.24%\u548c61.56%\uff0c\u8fdc\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u768448.12%\u548c38.28%\uff0c\u8fd9\u610f\u5473\u7740\u827e\u591a\u66ff\u5c3c\u6709\u6548\u964d\u4f4e\u4e86\u60a3\u8005\u9885\u5185\u75c5\u7076\u8fdb\u5c55\u98ce\u9669\u3002\u6b64\u5916\uff0c\u827e\u591a\u66ff\u5c3c\u4e2d\u4f4d\u9885\u5185\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u540c\u6837\u672a\u8fbe\u5230\uff0c\u5965\u5e0c\u66ff\u5c3c\u5219\u4e3a16.26\u4e2a\u6708\u3002<\/span><\/p>\n

\n

<\/a><\/p>\n<\/div>\n

\u00a0<\/p>\n

\n

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\u4ece\u5168\u8eab\u6297\u80bf\u7624\u7597\u6548\u7ef4\u5ea6\u6765\u770b\uff0c\u7ecfBICR\u8bc4\u4f30\u663e\u793a\uff0c\u827e\u591a\u66ff\u5c3c\u7ec4\u6574\u4f53\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a89.2%\uff0c\u5965\u5e0c\u66ff\u5c3c\u7ec4\u4e3a77.9%\uff08P=0.<\/span>0301\uff09\uff1b\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5c1a\u672a\u8fbe\u5230\uff0c\u5bf9\u6bd4\u5bf9\u7167\u7ec417.22\u4e2a\u6708\u5f62\u6210\u660e\u663e\u4f18\u52bf\uff08HR=0.64\uff0cP=0.0473\uff09\uff0c\u8fd9\u4e5f\u610f\u5473\u7740\u827e\u591a\u66ff\u5c3c\u53ef\u6709\u6548\u5ef6\u7f13\u5168\u8eab\u80bf\u7624\u8fdb\u5c55\uff0c\u4e3a\u60a3\u8005\u4e89\u53d6\u66f4\u957f\u751f\u5b58\u5468\u671f\u3002\u76ee\u524d\u7814\u7a76\u603b\u751f\u5b58\u671f\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u540e\u7eed\u968f\u8bbf\u4ecd\u5728\u6301\u7eed\u63a8\u8fdb\u3002<\/p>\n

\n

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\u6297\u80bf\u7624\u521b\u65b0\u836f\u7684\u4e34\u5e8a\u843d\u5730\uff0c\u7597\u6548\u4e0e\u5b89\u5168\u7f3a\u4e00\u4e0d\u53ef\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u827e\u591a\u66ff\u5c3c\u6574\u4f53\u5b89\u5168\u8c31\u53ef\u63a7\u53ef\u8010\u53d7\u3002\u4e24\u7ec4\u6cbb\u7597\u671f\u95f4\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u76f8\u8fd1\uff0c\u867d\u827e\u591a\u66ff\u5c3c\u7ec43\u7ea7\u53ca\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a49.5%\uff0c\u4f46\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u4e3a\u8f7b\u4e2d\u5ea6\uff0c\u7ecf\u5bf9\u75c7\u5e72\u9884\u3001\u5242\u91cf\u8c03\u6574\u540e\u5747\u53ef\u6709\u6548\u7f13\u89e3\u3002<\/p>\n

\n

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\u7efc\u4e0a\uff0cESAONA\u5934\u5bf9\u5934\u4f18\u6548\u7814\u7a76\u7a81\u7834\u4e86\u65e2\u5f80EGFR-TKI\u8111\u8f6c\u79fb\u4e34\u5e8a\u63a2\u7d22\u5c40\u9650\uff0c\u4ee5\u786e\u51ff\u4e34\u5e8a\u6570\u636e\u8bc1\u660e\u65b0\u4e00\u4ee3\u836f\u7269\u6709\u671b\u91cd\u5851EGFR\u8111\u8f6c\u79fb\u4e00\u7ebf\u9776\u5411\u6cbb\u7597\u7684\u8bc4\u4ef7\u6807\u5c3a\uff0c\u4e3a\u5168\u7403\u540c\u7c7b\u836f\u7269\u7814\u53d1\u4e0e\u4e34\u5e8a\u65b9\u6848\u4f18\u5316\u63d0\u4f9b\u6765\u81ea\u4e2d\u56fd\u7684\u9ad8\u7ea7\u522b\u5faa\u8bc1\u8bc1\u636e\u3002<\/p>\n

\u4e0a\u5e02\u7533\u62a5\u9a76\u5165\u5feb\u8f66\u9053\uff0c\u521b\u65b0\u5236\u5242\u6709\u671b\u91cd\u5851\u80ba\u764c\u8111\u8f6c\u79fb\u4e34\u5e8a\u8bca\u7597\u7248\u56fe<\/p>\n

EGFR\u7a81\u53d8\u662f\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6700\u5e38\u89c1\u7684\u9a71\u52a8\u7a81\u53d8\u7c7b\u578b\uff0c\u800c\u8111\u8f6c\u79fb\u4f5c\u4e3a\u80ba\u764c\u6700\u51f6\u9669\u7684\u8f6c\u79fb\u5f62\u5f0f\uff0c\u4e0d\u4ec5\u4f1a\u5927\u5e45\u7f29\u77ed\u60a3\u8005\u751f\u5b58\u671f\uff0c\u8fd8\u4f1a\u4e25\u91cd\u635f\u5bb3\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\uff0c\u4e00\u76f4\u662f\u4e34\u5e8a\u8bca\u7597\u7684\u68d8\u624b\u96be\u9898\u3002<\/p>\n

\u5f53\u524d\u4e3b\u6d41\u7b2c\u4e09\u4ee3EGFR-TKI\u867d\u80fd\u6709\u6548\u63a7\u5236\u5168\u8eab\u80bf\u7624\u75c5\u7076\uff0c\u4f46\u53d7\u9650\u4e8e\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u80fd\u529b\u4e0d\u8db3\uff0c\u5bf9\u9885\u5185\u8f6c\u79fb\u75c5\u7076\u7684\u6291\u5236\u6548\u679c\u59cb\u7ec8\u5b58\u5728\u77ed\u677f\uff0c\u7597\u6548\u96be\u4ee5\u6ee1\u8db3\u4e34\u5e8a\u521a\u9700\uff0c\u4e34\u5e8a\u4e0a\u4e9f\u9700\u4e00\u6b3e\u9885\u5185\u7597\u6548\u66f4\u5f3a\u3001\u5b89\u5168\u8010\u53d7\u6027\u66f4\u4f73\u7684\u65b0\u4e00\u4ee3\u6cbb\u7597\u836f\u7269\u3002<\/p>\n

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\n<\/div>\n

SOURCE \u540c\u6e90\u5eb7\u533b\u836f<\/p>","protected":false},"excerpt":{"rendered":"

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