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\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\u8be5\u7814\u7a76\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u5df2\u4e8e5\u670820\u65e5\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\uff0c\u672c\u9879II\u671f\u7814\u7a76\u7531\u548c\u8a89\u533b\u836f\u4e3b\u5bfc\uff0c\u548c\u8a89\u533b\u836f\u548c\u963f\u65af\u5229\u5eb7\u5c06\u5171\u540c\u5206\u62c5\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76f8\u5173\u8d23\u4efb\u3002<\/p>\n

Lumipodlin\u662f\u4e00\u6b3e\u6f5c\u5728\u7684First-in-class\u53e3\u670d\u5c0f\u5206\u5b50PD-L1\u6291\u5236\u5242\uff0c\u9664\u4e86\u53e3\u670d\u7ed9\u836f\u7684\u4f18\u52bf\uff0c\u8fd8\u8868\u73b0\u51fa\u5176\u4ed6\u5dee\u5f02\u5316\u4f18\u52bf\u3002\u76ee\u524d\uff0c\u4ee5\u5965\u5e0c\u66ff\u5c3c\u4e3a\u4ee3\u8868\u7684\u7b2c\u4e09\u4ee3EGFR-TKI\u5df2\u6210\u4e3aEGFR\u7a81\u53d8\u665a\u671fNSCLC\u7684\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u5bf9\u4e8eEGFR\u7a81\u53d8\u5408\u5e76PD-L1\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\uff0c\u5176\u7597\u6548\u52a3\u4e8ePD-L1\u4f4e\u8868\u8fbe\u6216\u9634\u6027\u60a3\u8005[1],[2]\uff0c\u5728EGFR\u7a81\u53d8\u5408\u5e76PD-L1\u9633\u6027\u7684NSCLC\u60a3\u8005\u4e2d\u957f\u671f\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002<\/p>\n

\u53c2\u8003\u6587\u732e
[1]\u00a0 Brown H, Vansteenkiste J, Nakagawa K, et al. Programmed cell death ligand 1 expression in untreated EGFR mutated advanced NSCLC and response to osimertinib versus comparator in FLAURA. J Thorac Oncol. 2020;15(1):138\u2013143.<\/p>\n

[2]\u00a0 \u00a0Niu J, Jing X, Xu Q, et al. Strong PD-L1 affect clinical outcomes in advanced NSCLC treated with third-generation EGFR-TKIs. Future Oncol. 2024;20(32):2481-2490.<\/p>\n

\u5173\u4e8eLumipodlin\uff08ABSK043\uff09
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\u5173\u4e8e\u5965\u5e0c\u66ff\u5c3c
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\u66f4\u591a\u4fe1\u606f\uff0c\u6b22\u8fce\u8bbf\u95ee www.abbisko.com<\/a>\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7
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Disclaimer: The indication for the combination therapy referenced in this document has not been approved in China. AstraZeneca and Abbisko Therapeutics do not recommend the use of any unapproved medicines.<\/p>\n

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Programmed cell death ligand 1 expression in untreated EGFR mutated advanced NSCLC and response to osimertinib versus comparator in FLAURA. J Thorac Oncol. 2020;15(1):138\u2013143. [2]\u00a0 \u00a0Niu J, Jing X, Xu Q, et al. 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