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\u2014 ONC-783 \u662f\u5168\u7403\u9996\u6b3e\u4e14\u76ee\u524d\u552f\u4e00\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3001\u9776\u5411 CD24 \u80bf\u7624\u7279\u5f02\u6027\u7cd6\u578b\uff08neoCD24\uff09\u7684 T \u7ec6\u80de\u8854\u63a5\u5668 \u2014<\/p>\n

\u2014 \u76ae\u4e0b\u5236\u5242\u65e8\u5728\u5b9e\u73b0\u66f4\u5e73\u7f13\u7684\u5168\u8eab\u836f\u7269\u66b4\u9732\uff0c\u6709\u671b\u964d\u4f4e\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u98ce\u9669 \u2014<\/p>\n

\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14<\/span>2026\u5e748\u670817\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5f00\u53d1\u764c\u75c7\u53ca\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u521b\u65b0\u836f\u7269\u7684\u4e34\u5e8a\u5f00\u53d1\u540e\u671f\u751f\u7269\u5236\u836f\u516c\u53f8 OncoC4 Inc. \u4eca\u65e5\u5ba3\u5e03\uff0c\u5176\u57fa\u4e8e\u4e13\u6709 neoCD24 \u5e73\u53f0\u5f00\u53d1\u7684\u5728\u7814 T \u7ec6\u80de\u8854\u63a5\u5668 ONC-783\uff0c\u5df2\u5b8c\u6210 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT07408258\uff09\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002\u6b64\u524d\uff0c\u8be5\u8bd5\u9a8c\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u5df2\u83b7\u6279\u51c6\u3002<\/p>\n

\n<\/div>\n

OncoC4 \u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u79d1\u5b66\u5b98 Yang Liu \u535a\u58eb\u8868\u793a\uff1a\u201c\u8fd9\u4e00\u91cc\u7a0b\u7891\u5f70\u663e\u4e86 OncoC4 \u5728\u5f00\u53d1\u540c\u7c7b\u9996\u521b\u764c\u75c7\u7597\u6cd5\u65b9\u9762\u7684\u9886\u5148\u5730\u4f4d\u3002CD24 \u5728\u8fd1 70% \u7684\u4eba\u7c7b\u764c\u75c7\u4e2d\u8868\u8fbe1\uff0c\u800c\u6076\u6027\u7ec6\u80de\u4e2d\u7684\u5f02\u5e38\u7cd6\u57fa\u5316\u53ef\u4ea7\u751f neoCD24 \u8868\u4f4d\uff0c\u8be5\u8868\u4f4d\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u57fa\u672c\u4e0d\u5b58\u5728\u3002ONC-783 \u5229\u7528\u8fd9\u4e00\u80bf\u7624\u7279\u5f02\u6027\u8868\u4f4d\uff0c\u529b\u6c42\u6700\u5927\u7a0b\u5ea6\u63d0\u9ad8\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u9009\u62e9\u6027\uff0c\u540c\u65f6\u5c3d\u53ef\u80fd\u964d\u4f4e\u5728\u9776\u8131\u7624\uff08on-target\/off-tumor\uff09\u6bd2\u6027\u98ce\u9669\uff0c\u800c\u8fd9\u4e00\u98ce\u9669\u6b63\u662f\u9650\u5236\u5176\u4ed6 T \u7ec6\u80de\u8854\u63a5\u5668\u5e94\u7528\u7684\u56e0\u7d20\u4e4b\u4e00\u3002\u201d<\/p>\n

ONC-783 \u662f\u5168\u7403\u9996\u6b3e\u4e14\u76ee\u524d\u552f\u4e00\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3001\u9776\u5411 CD24 \u80bf\u7624\u7279\u5f02\u6027\u7cd6\u578b\uff08neoCD24\uff09\u7684 T \u7ec6\u80de\u8854\u63a5\u5668\u3002\u8be5\u5019\u9009\u836f\u7269\u901a\u8fc7\u9009\u62e9\u6027\u9776\u5411\u80bf\u7624\u7279\u5f02\u6027\u8868\u4f4d\uff0c\u540c\u65f6\u5c06 T \u7ec6\u80de\u91cd\u5b9a\u5411\u81f3\u80bf\u7624\u7ec6\u80de\uff0c\u4ee5\u4ea7\u751f\u5f3a\u6548\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u65e8\u5728\u7a81\u7834\u73b0\u6709\u514d\u75ab\u7597\u6cd5\u7684\u5c40\u9650\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cONC-783 \u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u53ca\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u5177\u6709\u5e7f\u6cdb\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u80f0\u817a\u764c\u3001\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u5375\u5de2\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u663e\u793a\u51fa\u6cbb\u7597\u591a\u4e2a\u7624\u79cd\u7684\u6f5c\u529b\u3002\u6b64\u5916\uff0cOncoC4 \u8fd8\u4e3a ONC-783 \u5f00\u53d1\u4e86\u76ae\u4e0b\u7ed9\u836f\u5236\u5242\uff0c\u4ee5\u5b9e\u73b0\u66f4\u4e3a\u5e73\u7f13\u7684\u5168\u8eab\u836f\u7269\u66b4\u9732\u3002\u4e0e\u9759\u8109\u7ed9\u836f\u7684 T \u7ec6\u80de\u8854\u63a5\u5668\u76f8\u6bd4\uff0c\u8be5\u5236\u5242\u6709\u671b\u5e26\u6765\u5b89\u5168\u6027\u4f18\u52bf\u3002<\/p>\n

\u7ebd\u7ea6\u5e02 Columbia University Irving Medical Center \u533b\u5b66\u6559\u6388\u517c\u80bf\u7624\u5185\u79d1\u533b\u751f Aiwu Ruth He \u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u4e0e OncoC4 \u5408\u4f5c\uff0c\u5171\u540c\u63a2\u7d22\u9776\u5411 neoCD24 \u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u4e3a\u6cbb\u7597\u9009\u62e9\u6709\u9650\u7684\u764c\u75c7\u60a3\u8005\u5e26\u6765\u4e34\u5e8a\u83b7\u76ca\u3002\u665a\u671f\u5b9e\u4f53\u7624\u4ecd\u662f\u4e34\u5e8a\u6cbb\u7597\u9762\u4e34\u7684\u91cd\u5927\u6311\u6218\u3002\u5bf9\u4e8e\u6807\u51c6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u5bf9\u6807\u51c6\u6cbb\u7597\u4e0d\u8010\u53d7\u7684\u60a3\u8005\uff0c\u8fd9\u4e00\u521b\u65b0\u4f5c\u7528\u673a\u5236\u6709\u671b\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

ONC-783 \u76ee\u524d\u6b63\u5728\u7f8e\u56fd\u5f00\u5c55\u7684 ONC-783-001 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u8bc4\u4f30\uff0c\u53d7\u8bd5\u8005\u4e3a\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u3002\u9996\u4f8b\u60a3\u8005\u5df2\u5728 Columbia University Irving Medical Center \u987a\u5229\u5b8c\u6210\u7ed9\u836f\uff0c\u4e14\u5bf9\u6cbb\u7597\u8010\u53d7\u826f\u597d\u3002\u622a\u81f3\u76ee\u524d\uff0c\u5c1a\u672a\u89c2\u5bdf\u5230\u91cd\u5ea6\u4e0d\u826f\u4e8b\u4ef6\u3001\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u6216\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\u7efc\u5408\u5f81\uff08ICANS\uff09\u3002OncoC4 \u5c06\u7ee7\u7eed\u63a8\u52a8\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u521b\u65b0\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u540c\u7c7b\u9996\u521b\u7597\u6cd5\uff0c\u4ee5\u6ee1\u8db3\u764c\u75c7\u6cbb\u7597\u9886\u57df\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n

\u5173\u4e8e ONC-783-001<\/p>\n

ONC-783-001 \u662f\u4e00\u9879\u5728\u7f8e\u56fd\u5f00\u5c55\u7684 I \u671f\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30 ONC-783 \u5355\u836f\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u53ca\u7597\u6548\uff0c\u91cd\u70b9\u7eb3\u5165\u7ed3\u76f4\u80a0\u764c\u3001\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\u6216\u4e73\u817a\u764c\u60a3\u8005\u3002OncoC4 \u5df2\u4e0e\u7f8e\u56fd\u591a\u5bb6\u4e34\u5e8a\u4e2d\u5fc3\u5408\u4f5c\u5f00\u5c55 ONC-783-001 \u7684\u60a3\u8005\u62db\u52df\u5de5\u4f5c\uff0c\u5305\u62ec Columbia University Irving Medical Center \u548c The University of Texas MD Anderson Cancer Center\u3002\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6ce8\u518c\u7f16\u53f7\u4e3a NCT07408258\u3002<\/p>\n

\u5173\u4e8e neoCD24 \u5e73\u53f0<\/p>\n

CD24 \u5728\u8fd1 70% \u7684\u4eba\u7c7b\u764c\u75c7\u4e2d\u8868\u8fbe1\uff0c\u540c\u65f6\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u4e5f\u6709\u8f83\u9ad8\u6c34\u5e73\u7684\u8868\u8fbe\uff0c\u5e76\u5728\u6b63\u5e38\u7ec6\u80de\u751f\u957f\u3001\u7ec4\u7ec7\u7ef4\u6301\u53ca\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u7531\u4e8e\u96be\u4ee5\u9009\u62e9\u6027\u9776\u5411\u80bf\u7624\u7ec6\u80de\uff0c\u4ee5 CD24 \u4e3a\u9776\u70b9\u5f00\u53d1\u764c\u75c7\u7597\u6cd5\u4e00\u76f4\u9762\u4e34\u6311\u6218\u3002OncoC4 \u53d1\u73b0\uff0c\u6076\u6027\u7ec6\u80de\u4e2d\u7684\u5f02\u5e38\u7cd6\u57fa\u5316\u53ef\u4ea7\u751f neoCD24 \u8868\u4f4d\u3002\u8be5\u8868\u4f4d\u662f\u4e00\u79cd\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff0c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u57fa\u672c\u4e0d\u5b58\u5728\uff0c\u4e3a\u5f00\u53d1\u9776\u5411 CD24 \u7684\u80bf\u7624\u7279\u5f02\u6027\u7597\u6cd5\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002OncoC4 \u6b63\u57fa\u4e8e neoCD24 \u5e73\u53f0\u5f00\u53d1\u591a\u6b3e\u540c\u7c7b\u9996\u521b\u764c\u75c7\u7597\u6cd5\u3002<\/p>\n

\u5173\u4e8e OncoC4<\/p>\n

OncoC4 \u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\uff0c\u662f\u4e00\u5bb6\u975e\u4e0a\u5e02\u3001\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u540e\u671f\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u53ca\u514d\u75ab\u6027\u75be\u75c5\u7684\u65b0\u578b\u751f\u7269\u5236\u5242\u3002OncoC4 \u7684\u4ea7\u54c1\u7ba1\u7ebf\u5305\u62ec\u591a\u6b3e\u5177\u6709\u540c\u7c7b\u9996\u521b\u53ca\u540c\u7c7b\u6700\u4f73\u6f5c\u529b\u7684\u5019\u9009\u836f\u7269\uff0c\u6db5\u76d6\u80bf\u7624\u548c\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u9776\u70b9\u53ca\u5df2\u5f97\u5230\u5145\u5206\u9a8c\u8bc1\u7684\u9776\u70b9\u3002\u5176\u4e2d\uff0cAI-081 \u662f\u4e00\u6b3e\u7531 OncoC4 \u62e5\u6709\u5168\u90e8\u6743\u76ca\u3001\u540c\u65f6\u9776\u5411 PD-1 \u548c VEGF \u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5019\u9009\u836f\u7269\u3002ONC-841 \u662f\u4e00\u6b3e\u540c\u7c7b\u9996\u521b\u7684\u6297 SIGLEC-10 \u6297\u4f53\uff0c\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u80bf\u7624\u9002\u5e94\u75c7 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002OncoC4 \u5df2\u4e0e BioNTech \u5efa\u7acb\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5171\u540c\u5f00\u53d1 gotistobart\uff08BNT316\/ONC-392\uff09\u3002\u8be5\u5019\u9009\u836f\u7269\u9776\u5411 CTLA-4\uff0c\u53ef\u9009\u62e9\u6027\u6e05\u9664\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u8c03\u8282\u6027 T \u7ec6\u80de\uff08Treg\uff09\uff0c\u76ee\u524d\u6b63\u5728\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u5f00\u5c55\u4e34\u5e8a\u5f00\u53d1\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff1awww.oncoc4.com<\/a>. \u00a0<\/p>\n

\u8054\u7cfb\u65b9\u5f0f<\/p>\n

\u5a92\u4f53\u5173\u7cfb
Pan Pan
 media@oncoc4.com<\/a><\/p>\n

\u6295\u8d44\u8005\u5173\u7cfb
Ryan Cui
 ir@oncoc4.com<\/a><\/p>\n

\u53c2\u8003\u6587\u732e<\/p>\n

Ju-Han Lee, Seo-Hee Kim, Eung-Seok Lee, Young-Sik Kim. CD24 overexpression in cancer development and progression: a meta-analysis Oncol Rep 2009 Nov;22(5):1149-56. doi: 10.3892\/or_00000548.<\/p>\n

SOURCE OncoC4<\/p>","protected":false},"excerpt":{"rendered":"

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\u7ec6\u80de\u8854\u63a5\u5668\u76f8\u6bd4\uff0c\u8be5\u5236\u5242\u6709\u671b\u5e26\u6765\u5b89\u5168\u6027\u4f18\u52bf\u3002 \u7ebd\u7ea6\u5e02 […]<\/p>\n","protected":false},"author":0,"featured_media":27472,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-27471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\nOncoC4 \u5ba3\u5e03 ONC-783 \u665a\u671f\u5b9e\u4f53\u7624 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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