{"id":28111,"date":"2026-09-03T08:36:00","date_gmt":"2026-09-03T08:36:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e4%b8%8e%e8%91%9b%e5%85%b0%e7%b4%a0%e5%8f%b2%e5%85%8b%e5%b0%b1kras-egfr%e6%8a%97%e4%bd%93%e5%81%b6%e8%81%94%e7%99%8c%e7%97%87%e8%8d%af%e7%89%a9\/"},"modified":"2026-09-03T08:36:00","modified_gmt":"2026-09-03T08:36:00","slug":"%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e4%b8%8e%e8%91%9b%e5%85%b0%e7%b4%a0%e5%8f%b2%e5%85%8b%e5%b0%b1kras-egfr%e6%8a%97%e4%bd%93%e5%81%b6%e8%81%94%e7%99%8c%e7%97%87%e8%8d%af%e7%89%a9","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83%e4%b8%8e%e8%91%9b%e5%85%b0%e7%b4%a0%e5%8f%b2%e5%85%8b%e5%b0%b1kras-egfr%e6%8a%97%e4%bd%93%e5%81%b6%e8%81%94%e7%99%8c%e7%97%87%e8%8d%af%e7%89%a9\/","title":{"rendered":"\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u4e0e\u845b\u5170\u7d20\u53f2\u514b\u5c31KRAS-EGFR\u6297\u4f53\u5076\u8054\u764c\u75c7\u836f\u7269\u8fbe\u6210\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"

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\n<\/div>\n

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\u5173\u4e8e\u548c\u9ec4\u533b\u836f\u7684ATTC<\/p>\n

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\u4f9d\u6258\u548c\u9ec4\u533b\u836f\u5728\u9776\u5411\u6cbb\u7597\u9886\u57df\u8d85\u8fc7\u4e8c\u5341\u5e74\u7684\u4e13\u4e1a\u79ef\u6dc0\uff0cATTC\u5e73\u53f0\u80fd\u591f\u5f00\u53d1\u8986\u76d6\u5e7f\u6cdb\u80bf\u7624\u7684\u5019\u9009\u836f\u7269\u3002\u901a\u8fc7\u6297\u4f53\u5f15\u5bfc\u7684\u9776\u5411\u9012\u9001\u4ee5\u53ca\u5177\u6709\u80bf\u7624\u7279\u5f02\u6027\u7684\u6709\u6548\u8f7d\u8377\u91ca\u653e\u6280\u672f\uff0cATTC\u4f7f\u836f\u7269\u66f4\u6613\u76f4\u8fbe\u80bf\u7624\uff0c\u5e76\u964d\u4f4e\u5bf9\u975e\u80bf\u7624\u7ec4\u7ec7\u7684\u6bd2\u6027\u3002\u8fd9\u6709\u52a9\u4e8e\u514b\u670d\u5168\u8eab\u7ed9\u836f\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u5728\u975e\u80bf\u7624\u9776\u5411\u6bd2\u6027\u65b9\u9762\u7684\u9650\u5236\uff0c\u4ece\u800c\u786e\u4fdd\u957f\u671f\u7528\u836f\u7684\u5b89\u5168\u6027\uff0c\u5e76\u652f\u6301\u5728\u66f4\u65e9\u7684\u6cbb\u7597\u7ebf\u4e2d\u4e0e\u5316\u7597\u548c\u514d\u75ab\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u3002<\/p>\n

\u5173\u4e8eKRAS<\/p>\n

\u5927\u9f20\u8089\u7624\uff08”RAS”\uff09\u7a81\u53d8\u662f\u4eba\u7c7b\u80bf\u7624\u5b66\u4e2d\u6700\u5e38\u89c1\u4e14\u660e\u786e\u7684\u9a71\u52a8\u56e0\u7d20\u4e4b\u4e00\uff0c\u63a8\u52a8\u7740\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u8fdb\u5c55\u548c\u4fb5\u88ad\u6027\u75c5\u7406\u7279\u5f81\u3002KRAS\u4f5c\u4e3a\u6700\u4e3b\u8981\u7684RAS\u4e9a\u578b\uff0c\u5b58\u5728\u4e8e\u7ea644%\u7684\u7ed3\u76f4\u80a0\u764c\u300134%\u7684\u80ba\u817a\u764c\uff0c\u4ee5\u53ca\u9ad8\u8fbe89%\u7684\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u60a3\u8005\u4e2d\u3002[1] KRAS\u8c03\u63a7\u5173\u952e\u7684\u4e0b\u6e38\u901a\u8def\uff0c\u5305\u62ecRAS\/MAPK\u548cPI3K\/AKT\/mTOR\u901a\u8def\uff0c\u4ece\u800c\u9a71\u52a8\u7ec6\u80de\u5206\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u3002<\/p>\n

\u5c3d\u7ba1\u8fd1\u5e74\u6765\u51fa\u73b0\u7684\u9776\u5411\u7597\u6cd5\u5df2\u8bc1\u5b9eKRAS\u662f\u4e00\u4e2a\u53ef\u884c\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u4f46\u4e34\u5e8a\u4e0a\u4ecd\u5b58\u5728\u663e\u8457\u7684\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\uff0c\u5c24\u5176\u662f\u5bf9\u4e8e\u643a\u5e26\u975eG12C\u7a81\u53d8\u7684\u60a3\u8005\u3002\u5927\u591a\u6570\u60a3\u8005\u6700\u7ec8\u4f1a\u56e0\u83b7\u5f97\u6027\u8010\u836f\u800c\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u8fd9\u4e3b\u8981\u662f\u7531\u4e0a\u6e38\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u7684\u4e0a\u8c03\u548c\u7ee7\u53d1\u6027\u7684KRAS\u6539\u53d8\u6240\u9a71\u52a8\u3002\u9664\u4e86\u7a81\u53d8\u8986\u76d6\u8303\u56f4\u7684\u5c40\u9650\u5916\uff0c\u5168\u8eab\u6027\u9012\u9001\u6cdbKRAS\u548c\u6cdbRAS\u6291\u5236\u5242\u8fd8\u4f1a\u9020\u6210\u9776\u5411\u6bd2\u6027\uff0c\u4f8b\u5982\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u56e0RAS\u901a\u8def\u6291\u5236\u5bfc\u81f4\u7684\u76ae\u80a4\u6bd2\u6027\u3002\u8fd9\u4e9b\u90fd\u4e3a\u7ed9\u836f\u65b9\u6848\u3001\u957f\u671f\u8010\u53d7\u6027\u4ee5\u53ca\u4e0e\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u6216\u514d\u75ab\u7597\u6cd5\u4e3a\u57fa\u77f3\u7684\u6807\u51c6\u6cbb\u7597\u7684\u8054\u5408\u7528\u836f\u5e26\u6765\u4e86\u6311\u6218\u3002<\/p>\n

\u5173\u4e8eEGFR<\/p>\n

EGFR \u662f\u4e00\u79cd\u5e7f\u6cdb\u8868\u8fbe\u7684\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5728\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\u3001\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5728\u5185\u7684\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\uff0c\u5df2\u88ab\u8bc1\u5b9e\u662f\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3001\u5b58\u6d3b\u548c\u75be\u75c5\u8fdb\u5c55\u7684\u9a71\u52a8\u56e0\u5b50\u3002EGFR\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\u4e0b\u6e38\u7684RAS\/MAPK\u548c PI3K\/AKT\/mTOR\u901a\u8def\uff0c\u4f7f\u8be5\u53d7\u4f53\u5904\u4e8eKRAS\u7684\u6b63\u4e0a\u6e38\u3002EGFR\u4e5f\u5df2\u6210\u4e3aKRAS\u9776\u5411\u6cbb\u7597\u8010\u836f\u7684\u5173\u952e\u9a71\u52a8\u56e0\u7d20\uff0c\u5c24\u5176\u662f\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u9002\u5e94\u6027\u53cd\u9988\u548c\u4e0a\u6e38EGFR\u4fe1\u53f7\u589e\u5f3a\u4f1a\u91cd\u65b0\u6fc0\u6d3bMAPK\u901a\u8def\uff0c\u4ece\u800c\u9650\u5236KRAS\u6291\u5236\u7684\u6df1\u5ea6\u548c\u6301\u4e45\u6027\u3002\u8fd9\u4e9b\u53d1\u73b0\u5171\u540c\u4e3aEGFR\u548cKRAS\u7684\u53cc\u91cd\u9776\u5411\u6cbb\u7597\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u7406\u8bba\u4f9d\u636e\uff0c\u4e0d\u4ec5\u9002\u7528\u4e8e\u7ed3\u76f4\u80a0\u764c\uff0c\u4e5f\u540c\u6837\u9002\u7528\u4e8e\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u5176\u4ed6\u9002\u5e94\u75c7\u3002<\/p>\n

\u5173\u4e8e\u845b\u5170\u7d20\u53f2\u514b<\/p>\n

\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u662f\u4e00\u5bb6\u4ee5”\u6c47\u805a\u79d1\u5b66\u3001\u6280\u672f\u4e0e\u4eba\u624d\uff0c\u5408\u529b\u8d85\u8d8a\uff0c\u5171\u514b\u75be\u75c5”\u4e3a\u4f7f\u547d\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u516c\u53f8\u3002\u5982\u9700\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.gsk.com<\/a>\u3002<\/p>\n

\u5173\u4e8e\u548c\u9ec4\u533b\u836f<\/p>\n

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\u524d\u77bb\u6027\u9648\u8ff0<\/p>\n

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\n

[1] Singhal A, Li BT & O’Reilly EM. Targeting KRAS in cancer.\u00a0Nat Med\u00a030, 969\u2013983 (2024). DOI: 10.1038\/s41591-024-02903-0<\/a><\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

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