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\n<\/div>\n

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\n<\/div>\n

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002\u5728\u5fc3\u8840\u7ba1\u53ca\u4ee3\u8c22\u75be\u75c5\u9886\u57df\uff0c\u7f57\u6c0f\u6b64\u6b21\u5e26\u6765\u4e864\u6b3e\u591a\u5143\u5316\u7684\u7814\u53d1\u7ba1\u7ebf\uff0c\u8986\u76d6\u4ece\u53e3\u670d\u5230\u6ce8\u5c04\u7b49\u591a\u79cd\u7ed9\u836f\u65b9\u5f0f\uff0c\u5e76\u5177\u6709\u521b\u65b0\u4f5c\u7528\u673a\u5236\uff0c\u65e8\u5728\u5168\u65b9\u4f4d\u6ee1\u8db3\u80a5\u80d6\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u4ee5\u53ca\u4ee3\u8c22\u76f8\u5173\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u7b49\u60a3\u8005\u590d\u6742\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u76ee\u524d\u5927\u90e8\u5206III\u671f\u8bd5\u9a8c\u5747\u5df2\u542f\u52a8\u3002\u4f5c\u4e3a\u4e00\u6b3e\u5148\u8fdb\u7684\u504f\u5411\u6027\u53cc\u9776\u70b9\u51cf\u91cd\u65b0\u836f\uff0cGLP-1\/GIP\u53d7\u4f53\u6fc0\u52a8\u5242Enicepatide\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u8d85\u91cd\u6216\u80a5\u80d6\uff0c2\u578b\u7cd6\u5c3f\u75c5\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9884\u9632\u4ee5\u53ca\u5fc3\u8870\u7b49\u3002RNA\u5e72\u6270\uff08RNAi\uff09\u7597\u6cd5Zilebesiran\uff0c\u6bcf\u5e74\u4ec5\u9700\u76ae\u4e0b\u7ed9\u836f\u4e24\u6b21\uff0c\u52a9\u529b\u63d0\u5347\u9ad8\u8840\u538b\u60a3\u8005\u7684\u6cbb\u7597\u4fbf\u5229\u6027\u548c\u4f9d\u4ece\u6027\uff0c\u6709\u671b\u6210\u4e3a\u8bb8\u591a\u9ad8\u8840\u538b\u60a3\u8005\u7684\u957f\u671f\u75be\u75c5\u7ba1\u7406\u5168\u65b0\u9009\u62e9\u3002FGF21\u7c7b\u4f3c\u7269Pegozafermin\uff0c\u6709\u671b\u4e3a\u60a3\u8005\u7fa4\u4f53\u5e9e\u5927\u4e14\u6cbb\u7597\u9009\u62e9\u6709\u9650\u7684\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n

\u591a\u5143\u4f53\u9a8c\u6c47\u805a\u73b0\u573a\uff0c\u8ba9\u767e\u5e74\u521b\u65b0\u3001\u5408\u4f5c\u3001\u52a0\u7801\u4e2d\u56fd\u53ef\u611f\u53ef\u77e5<\/p>\n

\u7f57\u6c0f\u7684\u521b\u65b0\u8de8\u8d8a\u4e0d\u6b62\u4e8e\u5b9e\u9a8c\u5ba4\u4e0e\u8bca\u7597\u573a\u666f\uff0c\u4e5f\u4f53\u73b0\u5728\u5c55\u53f0\u73b0\u573a\u4e0e\u516c\u4f17\u7684\u6df1\u5ea6\u94fe\u63a5\u3002\u7f57\u6c0f\u5728\u672c\u6b21\u8fdb\u535a\u4f1a\u73b0\u573a\u501f\u52a9\u79d1\u6280\u8d4b\u80fd\u548c\u521b\u65b0\u89c6\u89d2\uff0c\u590d\u523b\u4e86\u767e\u5e74\u524d\u7684\u8001\u836f\u623f\uff0c\u6253\u9020\u4e86\u4e00\u573a\u5386\u53f2\u4e0e\u672a\u6765\u4ea4\u7ec7\u3001\u533b\u5b66\u4e0e\u4eba\u6587\u4ea4\u6c47\u7684\u8de8\u65f6\u7a7a\u4e92\u52a8\uff0c\u5168\u666f\u5448\u73b0\u7f57\u6c0f\u5728\u534e\u65e9\u671f\u8db3\u8ff9\u4e0e\u591a\u5143\u4ea7\u54c1\u3001\u5168\u4ea7\u4e1a\u94fe\u5e03\u5c40\u3001\u6700\u65b0\u521b\u65b0\u6210\u679c\u548c\u672a\u6765\u53d1\u5c55\u56fe\u666f\uff0c\u8ba9\u89c2\u4f17\u6c89\u6d78\u5f0f\u611f\u53d7\u7f57\u6c0f\u767e\u5e74\u6765\u6df1\u8015\u4e2d\u56fd\u7684\u52a8\u4eba\u6545\u4e8b\u548c\u4ee5\u521b\u65b0\u62a4\u4f51\u751f\u547d\u7684\u4e0d\u53d8\u521d\u5fc3\u3002<\/p>\n

\n<\/div>\n

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[1] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. DOI: 10.1056\/NEJMoa2410965\uff08REGENCY\uff0cNCT04221477\uff09392(15):1471\u20131483<\/p>\n

[2] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. DOI: 10.1056\/NEJMoa2410965\uff08REGENCY\uff0cNCT04221477\uff09392(15):1471\u20131483<\/p>\n

\n<\/div>\n

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[1] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. DOI: 10.1056\/NEJMoa2410965\uff08REGENCY\uff0cNCT04221477\uff09392(15):1471\u20131483 [2] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. 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[1] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. DOI: 10.1056\/NEJMoa2410965\uff08REGENCY\uff0cNCT04221477\uff09392(15):1471\u20131483 [2] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. 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[1] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. DOI: 10.1056\/NEJMoa2410965\uff08REGENCY\uff0cNCT04221477\uff09392(15):1471\u20131483 [2] Furie RA, et al. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025. 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