{"id":31608,"date":"2026-11-04T19:32:00","date_gmt":"2026-11-04T19:32:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e7%be%8e%e7%ba%b3%e9%87%8c%e5%b0%bc%e9%9b%86%e5%9b%a2%e5%92%8c-ryvu-therapeutics-%e5%9c%a8-2026-%e5%b9%b4-ash-%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86%e9%92%88%e5%af%b9%e4%b8%a5\/"},"modified":"2026-11-04T19:32:00","modified_gmt":"2026-11-04T19:32:00","slug":"%e7%be%8e%e7%ba%b3%e9%87%8c%e5%b0%bc%e9%9b%86%e5%9b%a2%e5%92%8c-ryvu-therapeutics-%e5%9c%a8-2026-%e5%b9%b4-ash-%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86%e9%92%88%e5%af%b9%e4%b8%a5","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e7%be%8e%e7%ba%b3%e9%87%8c%e5%b0%bc%e9%9b%86%e5%9b%a2%e5%92%8c-ryvu-therapeutics-%e5%9c%a8-2026-%e5%b9%b4-ash-%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86%e9%92%88%e5%af%b9%e4%b8%a5\/","title":{"rendered":"\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u548c Ryvu Therapeutics \u5728 2026 \u5e74 ASH \u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u9488\u5bf9\u4e25\u91cd\u9884\u5904\u7406\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u4fb5\u88ad\u6027 B \u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684 dapolsertib\uff08MEN1703\u3001SEL24\uff09 \u4e8c\u671f JASPIS-01 \u7814\u7a76\u7684\u9996\u6279\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"

dapolsertib \u5355\u4e00\u7597\u6cd5\u7684\u9996\u6279\u4e34\u5e8a\u6570\u636e\uff1a\u9488\u5bf9\u5df2\u7528\u5c3d\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u9009\u62e9\u7684\u590d\u53d1\/\u96be\u6cbb\u6027 (r\/r) \u4fb5\u88ad\u6027 B \u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624 (B-NHL) \u60a3\u8005\u7684\u540c\u7c7b\u9996\u521b\u53e3\u670d PIM\/FLT3 \u6fc0\u9176\u6291\u5236\u5242 dapolsertib (MEN1703) \u7684 II \u671f JASPIS-01 \u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u3002<\/p>\n

\u5728\u7ecf\u8fc7\u5927\u91cf\u9884\u5904\u7406\u7684\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230\u7684\u4e34\u5e8a\u6d3b\u6027\uff1a\u5728\u5148\u524d\u63a5\u53d7\u8fc7\u56db\u79cd\u6cbb\u7597\u7684\u4e2d\u4f4d\u6570\u7684\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230\u4e34\u5e8a\u6d3b\u6027\uff1b53% \u7684\u60a3\u8005\u4e4b\u524d\u63a5\u53d7\u8fc7 CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c60% \u7684\u60a3\u8005\u63a5\u53d7\u8fc7CD3\u00d7CD20\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002<\/p>\n

\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff1a\u5728 CAR-T \u7ec6\u80de\u6cbb\u7597\u548c\/\u6216 CD3\u00d7CD20 \u53cc\u7279\u5f02\u6027\u6297\u4f53\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u6709\u9650\uff0c\u9884\u540e\u4e5f\u5f88\u5dee\u3002<\/p>\n

ASH 2026 \u4e0a\u7684\u6d77\u62a5\u5c55\u793a\uff1a\u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e2026\u5e7412\u670813\u65e5\u5728\u7f8e\u56fd\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c68\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u548c\u535a\u89c8\u4f1a\u4e0a\u516c\u5e03\u3002<\/p>\n

\u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u6ce2\u5170\u514b\u62c9\u79d1\u592b<\/span>2026\u5e7411\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u9886\u5148\u7684\u56fd\u9645\u5236\u836f\u548c\u8bca\u65ad\u516c\u53f8\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\uff08\u201c\u7f8e\u7eb3\u91cc\u5c3c\u201d\uff09\u548c\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u7684\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc.\uff08\u201cStemline\u201d\uff09\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u53d8\u9769\u6027\u80bf\u7624\u7597\u6cd5\uff0c\u4ee5\u53caRyvu Therapeutics\uff08WSE\uff1aRVU\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u6b63\u5728\u8fdb\u884c\u7684\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027B-NHL\u60a3\u8005\u7684dapolsertib\uff08MEN1703\uff0cSEL24\uff09\u4e8c\u671f JASPIS-01 \u7814\u7a76\uff08NCT06534437\uff09\u7684\u9996\u6279\u4e34\u5e8a\u6570\u636e \u5c06\u57282026\u5e7412\u670812\u65e5\u81f315\u65e5\u5728\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c68\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u548c\u535a\u89c8\u4f1a\u7684\u6d77\u62a5\u53d1\u5e03\u4f1a\u4e0a\u516c\u5e03\u3002<\/p>\n

\n<\/div>\n

Dapolsertib\u662f\u540c\u7c7b\u9996\u521b\u7684\u53e3\u670d\u53cc\u91cdPIM\/FLT3\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5df2\u663e\u793a\u51fa\u4e34\u5e8a\u524d\u6297\u80bf\u7624\u6d3b\u6027\u4ee5\u53ca\u4e0e\u6297CD20\u5bfc\u5411\u7597\u6cd5\u7684\u534f\u540c\u4f5c\u7528\u3002\u8be5\u6458\u8981\u62a5\u544a\u4e86 JASPIS-01 \u7814\u7a76\u7b2c 2 \u7ec4\u7684\u9996\u6279\u4e34\u5e8a\u7ed3\u679c\uff0c\u8be5\u7ec4\u8bc4\u4f30\u4e86\u5728\u63a5\u53d7\u81f3\u5c11\u4e24\u6b21\u5168\u8eab\u7597\u6cd5\u540e\u5df2\u7ecf\u7528\u5c3d\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u7684\u6210\u5e74\u590d\u53d1\/\u96be\u6cbb\u6027 B-NHL \u7684\u6210\u5e74\u4eba\u670d\u7528 dapolsertib \u5355\u4e00\u7597\u6cd5\uff08125 mg\uff0c\u5728 21 \u5929\u5468\u671f\u7684\u7b2c 1-14 \u5929\u53e3\u670d\u4e00\u6b21\uff09\u3002\u5728\u7ecf\u8fc7\u5927\u91cf\u9884\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e34\u5e8a\u6d3b\u6027\u3002\u5b89\u5168\u6982\u51b5\u662f\u53ef\u63a7\u7684\uff0c\u5141\u8bb8\u5728\u9884\u671f\u5242\u91cf\u6c34\u5e73\u4e0a\u7ed9\u836fdapolsertib\u3002<\/p>\n

\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u9996\u5e2d\u6267\u884c\u5b98\u57c3\u5c14\u8f9b\u2022\u5df4\u514b\u2022\u57c3\u5c14\u8d21\u8bf4\uff1a\u201c\u5728CAR-T\u7ec6\u80de\u7597\u6cd5\u548c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u4fb5\u88ad\u6027B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u6709\u9650\uff0c\u9884\u540e\u975e\u5e38\u5dee\u3002\u201d \u201c\u5728\u7ecf\u8fc7\u5927\u91cf\u9884\u5904\u7406\u7684\u60a3\u8005\u4e2d\u83b7\u5f97\u7684\u4ee4\u4eba\u9f13\u821e\u7684\u521d\u6b65\u53d1\u73b0\u652f\u6301\u4e86dapolsertib\u7684\u6301\u7eed\u4e34\u5e8a\u5f00\u53d1\uff0c\u8fd9\u662f\u540c\u7c7b\u9996\u521b\u7684\u53e3\u670d\u53ccPIM\/FLT3\u6291\u5236\u5242\uff0c\u662f\u8fd9\u79cd\u4e25\u5cfb\u75be\u75c5\u7684\u6f5c\u5728\u9009\u62e9\uff0c\u6211\u4eec\u671f\u5f85\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u53d6\u5f97\u8fdb\u4e00\u6b65\u6210\u679c\u3002\u201d<\/p>\n

\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u6765\u81ea JASPIS-01 \u7684\u9996\u6279\u4e34\u5e8a\u6570\u636e\u5c06\u5728\u9886\u5148\u7684\u8840\u6db2\u5b66\u4f1a\u8bae ASH \u4e0a\u516c\u5e03\u3002\u9274\u4e8e\u8be5\u75be\u75c5\u5728\u8be5\u4eba\u7fa4\u4e2d\u5177\u6709\u5f88\u5f3a\u7684\u4fb5\u7565\u6027<\/span>\uff0cJASPIS-01 \u7814\u7a76\u4e2d\u770b\u5230\u7684\u6d3b\u52a8<\/span>\u5c24\u5176\u4ee4\u4eba\u9f13\u821e\u3002\u201d Ryvu Therapeutics\u9996\u5e2d\u533b\u5b66\u5b98\u4ea8\u5fb7\u91cc\u514b\u2022\u8bfa\u76d6\u533b\u5b66\u535a\u58eb\u8bf4\u3002\u201c\u4f5c\u4e3adapolsertib\u7684\u53d1\u660e\u8005\u548c\u7f8e\u7eb3\u91cc\u5c3c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u7684\u8fd0\u8425\u5408\u4f5c\u4f19\u4f34\uff0c\u6211\u4eec\u4ecd\u7136\u81f4\u529b\u4e8e\u4e3a\u6025\u9700\u65b0\u6cbb\u7597\u9009\u62e9\u7684\u4fb5\u88ad\u6027B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u63a8\u5e7fdapolsertib\u3002\u201d<\/p>\n

\u6d77\u62a5\u5c55\u793a\u7684\u8be6\u60c5\u5982\u4e0b\uff1a
\u6d77\u62a5\u6807\u9898\uff1adapolsertib\uff08MEN1703\uff09\u662f\u540c\u7c7b\u9996\u521b\u7684\u53cc\u91cdPIM\/FLT3\u6291\u5236\u5242\uff0c\u5728\u7ecf\u8fc7\u5927\u91cf\u9884\u5904\u7406\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u4fb5\u88ad\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\u7684\u521d\u6b65\u4e34\u5e8a\u6d3b\u6027\u548c\u5b89\u5168\u6027\uff1aJASPIS-01 \u4e8c\u671f\u8bd5\u9a8c\u7684\u521d\u6b65\u7ed3\u679c
\u51fa\u7248\u7269\u7f16\u53f7\uff1a3662
\u4f1a\u8bdd\uff1a627\u3002\u4fb5\u88ad\u6027\u6dcb\u5df4\u7624\uff1a\u9776\u5411\u7597\u6cd5\u548c\u836f\u7269\u7597\u6cd5\uff1a\u7b2c\u4e8c
\u5c4a\u6d77\u62a5\u4f1a\u8bae\u65e5\u671f\u548c\u65f6\u95f4\uff1a2026 \u5e74 12 \u6708 13 \u65e5\u661f\u671f\u65e5\uff0c\u4e2d\u90e8\u6807\u51c6\u65f6\u95f4\u4e0b\u5348 6:00-8:00\uff08\u4e2d\u6b27\u6807\u51c6\u65f6\u95f4 12 \u6708 14 \u65e5\u51cc\u6668 1:00-3:00\uff09
\u5730\u70b9\uff1a\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5965\u5c14\u826f F \u5385\u6b27\u5185\u65af\u7279\u2022\u83ab\u91cc\u4e9a\u5c14\u4f1a\u8bae\u4e2d\u5fc3<\/p>\n

\u8be5\u6458\u8981\u53ef\u5728ASH\u7f51\u7ad9\u4e0a\u627e\u5230\uff1ahttps:\/\/www.hematology.org\/meetings\/annual-meeting <\/a><\/p>\n

\u5173\u4e8e JASPIS-01
JASPIS-01\uff08NCT06534437\uff09\u662f\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684\u4e8c\u671f\u7814\u7a76\uff0c\u8bc4\u4f30\u4e86\u5728\u63a5\u53d7\u81f3\u5c11\u4e24\u6b21\u5168\u8eab\u7597\u6cd5\u540e\uff0cdapolsertib\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0eglofitamab\u8054\u5408\u6cbb\u7597\u7684\u6210\u4eba\u590d\u53d1\/\u96be\u6cbb\u6027B-NHL\uff0c\u5305\u62ec\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u7684\u6210\u4eba\u3002\u7b2c 1 \u7ec4\u8bc4\u4f30\u4e86\u5bf9\u672a\u60a3\u6709 CD3\u00d7CD20 \u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u60a3\u8005\u4e2d\u8054\u5408\u4f7f\u7528\u8fbe\u666e\u897f\u66ff\u5e03\u4e0e\u683c\u6d1b\u975e\u4ed6\u5355\u6297\u7684\u60a3\u8005\u3002\u7b2c 2 \u7ec4\u5c06dapolsertib\u8bc4\u4f30\u4e3a\u5df2\u7528\u5c3d\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u7684\u60a3\u8005\u7684\u5355\u4e00\u7597\u6cd5\u3002\u6839\u636e\u5362\u52a0\u8bfa\u5206\u7c7b\uff0c\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\uff1b\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u3001\u65e0\u8fdb\u5c55\u5b58\u6d3b\u7387\uff08PFS\uff09\u3001\u603b\u5b58\u6d3b\u7387\uff08OS\uff09\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u5173\u4e8e dapolsertib
Dapolsertib\uff08MEN1703\u3001SEL24\uff09\u662f Ryvu \u53d1\u73b0\u7684\u540c\u7c7b\u9996\u6b3e\u53e3\u670d PIM \u548c FLT3 \u6fc0\u9176\u7684\u9009\u62e9\u6027\u5c0f\u5206\u5b50\u53cc\u91cd\u6291\u5236\u5242\u3002dapolsertib\u7684\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u7248\u6743\u5df2\u83b7\u5f97\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u7684\u8bb8\u53ef\u3002\u81ea2023\u5e749\u6708\u4ee5\u6765\uff0cRyvu\u4e00\u76f4\u662f\u7f8e\u7eb3\u91cc\u5c3c\u7b2c\u4e8c\u9636\u6bb5\u7814\u7a76\u6267\u884c\u7684\u8fd0\u8425\u5408\u4f5c\u4f19\u4f34\uff0c\u7f8e\u7eb3\u91cc\u5c3c\u4e3a\u6240\u6709\u7814\u53d1\u8d39\u7528\u63d0\u4f9b\u8d44\u91d1\u3002Dapolsertib\u662f\u4e00\u79cd\u7814\u7a76\u836f\u7269\uff0c\u5c1a\u672a\u83b7\u5f97\u4efb\u4f55\u76d1\u7ba1\u673a\u6784\u7684\u6279\u51c6\u3002<\/p>\n

\u5173\u4e8e Menarini Group
Menarini Group \u662f\u4e00\u5bb6\u56fd\u9645\u9886\u5148\u7684\u5236\u836f\u53ca\u8bca\u65ad\u516c\u53f8\uff0c\u8425\u4e1a\u989d\u8fbe 55 \u4ebf\u7f8e\u5143\uff0c\u5458\u5de5\u8d85\u8fc7 17,000 \u4eba\u3002Menarini \u4e13\u6ce8\u4e8e\u5b58\u5728\u5927\u91cf\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u6cbb\u7597\u9886\u57df\uff0c\u4ea7\u54c1\u6db5\u76d6\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80bf\u7624\u3001\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u3001\u80c3\u80a0\u9053\u75be\u75c5\u3001\u611f\u67d3\u6027\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u708e\u75c7\u53ca\u9547\u75db\u3002Menarini \u4ea7\u54c1\u904d\u53ca\u5168\u7403 140 \u4e2a\u56fd\u5bb6\/\u5730\u533a\uff0c\u62e5\u6709 18 \u4e2a\u751f\u4ea7\u57fa\u5730\u548c 9 \u4e2a\u7814\u53d1\u4e2d\u5fc3\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee www.menarini.com<\/a>\u3002<\/p>\n

\u5173\u4e8e Stemline Therapeutics Inc.
Stemline Therapeutics, Inc.\uff08\u201cStemline\u201d\uff09\u662f Menarini Group \u7684\u5168\u8d44\u5b50\u516c\u53f8\uff0c\u4e5f\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u4e3a\u60a3\u8005\u63d0\u4f9b\u53d8\u9769\u6027\u80bf\u7624\u6cbb\u7597\u65b9\u6848\u3002Stemline \u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u5168\u7403\u5176\u4ed6\u5730\u533a\u5f00\u5c55 elacestrant \u7684\u5546\u4e1a\u5316\u4e1a\u52a1\u3002elacestrant \u662f\u4e00\u79cd\u53e3\u670d\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u7edd\u7ecf\u540e\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 2\uff08HER2\uff09\u9634\u6027\u3001\u643a\u5e26 ESR1 \u7a81\u53d8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002Stemline \u8fd8\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u5168\u7403\u5176\u4ed6\u5730\u533a\u5f00\u5c55 tagraxofusp-erzs \u7684\u5546\u4e1a\u5316\u4e1a\u52a1\u3002\u8fd9\u662f\u4e00\u79cd\u9776\u5411 CD123 \u7684\u65b0\u578b\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u6bcd\u7ec6\u80de\u6027\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\u80bf\u7624\uff08BPDCN\uff09\u60a3\u8005\u3002BPDCN \u662f\u4e00\u79cd\u4fb5\u88ad\u6027\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u3002\u6b64\u5916\uff0cStemline \u5728\u6b27\u6d32\u5f00\u5c55 selinexor \u7684\u5546\u4e1a\u5316\u4e1a\u52a1\uff0c\u8be5\u836f\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5242\u3002\u516c\u53f8\u8fd8\u5206\u522b\u9488\u5bf9\u4e73\u817a\u764c\u548c\u8840\u6db2\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5f00\u5c55 elacestrant \u53ca tagraxofusp \u7684\u591a\u9879\u9002\u5e94\u75c7\u62d3\u5c55\u7814\u7a76\uff0c\u5e76\u62e5\u6709\u5e7f\u6cdb\u7684\u4e34\u5e8a\u7814\u53d1\u7ba1\u7ebf\uff0c\u5305\u62ec\u591a\u6b3e\u9488\u5bf9\u5404\u79cd\u5b9e\u4f53\u7624\u53ca\u8840\u6db2\u80bf\u7624\u3001\u5904\u4e8e\u4e0d\u540c\u5f00\u53d1\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\u3002<\/p>\n

\u5173\u4e8eRyvu Therapeutics
Ryvu Therapeutics\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u9488\u5bf9\u80bf\u7624\u5b66\u65b0\u5174\u9776\u6807\u7684\u65b0\u7597\u6cd5\u3002Ryvu\u5185\u90e8\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u4f7f\u7528\u4e86\u7531\u764c\u75c7\u751f\u7269\u5b66\u65b0\u5174\u77e5\u8bc6\u9a71\u52a8\u7684\u591a\u79cd\u6cbb\u7597\u673a\u5236\uff0c\u5305\u62ec\u9488\u5bf9\u6fc0\u9176\u3001\u5408\u6210\u6740\u4f24\u529b\u548c\u514d\u75ab\u80bf\u7624\u5b66\u9776\u6807\u7684\u5c0f\u5206\u5b50\u548c\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u3002<\/p>\n

Ryvu\u6700\u5148\u8fdb\u7684\u9879\u76ee\u662fromaciclib\uff08RVU120\uff0cSEL120\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7684CDK8\/CDK19\u6fc0\u9176\u6291\u5236\u5242\uff0c\u6709\u53ef\u80fd\u6cbb\u7597\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u3002Romaciclib\u76ee\u524d\u6b63\u5904\u4e8e\u4e0evenetoclax\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684\u4e8c\u671f\uff08RIVER-81 \u7814\u7a76\uff09\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u8d77\u7684\u513f\u79d1\u9ad3\u6bcd\u7ec6\u80de\u7624I\u671f\u7814\u7a76\u2014\u2014MEDWAY\u7814\u7a76\u4e5f\u5728\u8bc4\u4f30\u4e2d\u3002Dapolsertib\uff08MEN1703\uff0cSEL24\uff09\u662f\u4e00\u79cd\u83b7\u5f97\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u8bb8\u53ef\u7684\u53cc\u91cdPIM\/FLT3\u6fc0\u9176\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u7684\u4e8c\u671f\u7814\u7a76\uff08JASPIS-01 \u7814\u7a76\uff09\u4e2d\u8fdb\u884c\u7814\u7a76\uff0c\u53e6\u4e00\u9879\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08SPHENE-01\uff09\u4e8c\u671f\u7814\u7a76\u8ba1\u5212\u4e8e2027\u5e74\u7b2c\u4e00\u5b63\u5ea6\u5f00\u59cb\u3002RVU305 \u53ef\u80fd\u662f\u4e00\u79cd\u65e8\u5728\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u540c\u7c7b\u6700\u4f73\u3001\u53ef\u6e17\u900f\u5927\u8111\u7684 PRMT5 \u6291\u5236\u5242\uff0c\u5df2\u7ecf\u5b8c\u6210\u4e86\u652f\u6301 IND\/CTA \u7684\u7814\u7a76\u3002Ryvu Therapeutics\u8fd8\u4e0eBioNTech\u548cExelixis\u5f00\u5c55\u80bf\u7624\u5b66\u5408\u4f5c\uff0c\u5e76\u901a\u8fc7\u5176Keelira\u4e1a\u52a1\u4e3a\u751f\u7269\u6280\u672f\u548c\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b\u4e13\u95e8\u7684\u65e9\u671f\u4e34\u5e8a\u5f00\u53d1\u670d\u52a1\u3002<\/p>\n

Ryvu \u6210\u7acb\u4e8e 2007 \u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u6ce2\u5170\u514b\u62c9\u79d1\u592b\u3002\u5b83\u5728\u534e\u6c99\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff0c\u00a0\u662fSWIG80\u6307\u6570\u7684\u00a0\u7ec4\u6210\u90e8\u5206\u3002<\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee www.ryvu.com\u00a0<\/a><\/p>\n

SOURCE Menarini Industrie Farmaceutiche Riunite<\/p>","protected":false},"excerpt":{"rendered":"

dapolsertib \u5355\u4e00\u7597\u6cd5\u7684\u9996\u6279\u4e34\u5e8a\u6570\u636e\uff1a\u9488\u5bf9\u5df2\u7528\u5c3d\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u9009\u62e9\u7684\u590d\u53d1\/\u96be\u6cbb\u6027 (r\/r) \u4fb5\u88ad\u6027 B \u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624 (B-NHL) \u60a3\u8005\u7684\u540c\u7c7b\u9996\u521b\u53e3\u670d PIM\/FLT3 \u6fc0\u9176\u6291\u5236\u5242 dapolsertib (MEN1703) \u7684 II \u671f JASPIS-01 \u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u3002 \u5728\u7ecf\u8fc7\u5927\u91cf\u9884\u5904\u7406\u7684\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230\u7684\u4e34\u5e8a\u6d3b\u6027\uff1a\u5728\u5148\u524d\u63a5\u53d7\u8fc7\u56db\u79cd\u6cbb\u7597\u7684\u4e2d\u4f4d\u6570\u7684\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230\u4e34\u5e8a\u6d3b\u6027\uff1b53% \u7684\u60a3\u8005\u4e4b\u524d\u63a5\u53d7\u8fc7 CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c60% \u7684\u60a3\u8005\u63a5\u53d7\u8fc7CD3\u00d7CD20\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002 \u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff1a\u5728 CAR-T \u7ec6\u80de\u6cbb\u7597\u548c\/\u6216 CD3\u00d7CD20 \u53cc\u7279\u5f02\u6027\u6297\u4f53\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u6709\u9650\uff0c\u9884\u540e\u4e5f\u5f88\u5dee\u3002 ASH 2026 \u4e0a\u7684\u6d77\u62a5\u5c55\u793a\uff1a\u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e2026\u5e7412\u670813\u65e5\u5728\u7f8e\u56fd\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c68\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u548c\u535a\u89c8\u4f1a\u4e0a\u516c\u5e03\u3002 \u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u6ce2\u5170\u514b\u62c9\u79d1\u592b2026\u5e7411\u67085\u65e5 \/\u7f8e\u901a\u793e\/ — \u9886\u5148\u7684\u56fd\u9645\u5236\u836f\u548c\u8bca\u65ad\u516c\u53f8\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\uff08\u201c\u7f8e\u7eb3\u91cc\u5c3c\u201d\uff09\u548c\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u7684\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc.\uff08\u201cStemline\u201d\uff09\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u53d8\u9769\u6027\u80bf\u7624\u7597\u6cd5\uff0c\u4ee5\u53caRyvu Therapeutics\uff08WSE\uff1aRVU\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u6b63\u5728\u8fdb\u884c\u7684\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027B-NHL\u60a3\u8005\u7684dapolsertib\uff08MEN1703\uff0cSEL24\uff09\u4e8c\u671f JASPIS-01 \u7814\u7a76\uff08NCT06534437\uff09\u7684\u9996\u6279\u4e34\u5e8a\u6570\u636e \u5c06\u57282026\u5e7412\u670812\u65e5\u81f315\u65e5\u5728\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c68\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u548c\u535a\u89c8\u4f1a\u7684\u6d77\u62a5\u53d1\u5e03\u4f1a\u4e0a\u516c\u5e03\u3002 Dapolsertib\u662f\u540c\u7c7b\u9996\u521b\u7684\u53e3\u670d\u53cc\u91cdPIM\/FLT3\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5df2\u663e\u793a\u51fa\u4e34\u5e8a\u524d\u6297\u80bf\u7624\u6d3b\u6027\u4ee5\u53ca\u4e0e\u6297CD20\u5bfc\u5411\u7597\u6cd5\u7684\u534f\u540c\u4f5c\u7528\u3002\u8be5\u6458\u8981\u62a5\u544a\u4e86 JASPIS-01 \u7814\u7a76\u7b2c 2 \u7ec4\u7684\u9996\u6279\u4e34\u5e8a\u7ed3\u679c\uff0c\u8be5\u7ec4\u8bc4\u4f30\u4e86\u5728\u63a5\u53d7\u81f3\u5c11\u4e24\u6b21\u5168\u8eab\u7597\u6cd5\u540e\u5df2\u7ecf\u7528\u5c3d\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u7684\u6210\u5e74\u590d\u53d1\/\u96be\u6cbb\u6027 B-NHL \u7684\u6210\u5e74\u4eba\u670d\u7528 dapolsertib \u5355\u4e00\u7597\u6cd5\uff08125 mg\uff0c\u5728 21 \u5929\u5468\u671f\u7684\u7b2c 1-14 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