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\n<\/div>\n
\n<\/div>\n

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\n<\/div>\n

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\u6b64\u5916\uff0c\u73b0\u573a\u8fd8\u56f4\u7ed5HCM\u89c4\u8303\u5316\u8bca\u7597\u4e0e\u5168\u7a0b\u7ba1\u7406\u5c55\u5f00\u8ba8\u8bba\u3002”\u5fc3\u8212\u534e\u590f”\u5fc3\u808c\u75c5\u4e13\u75c5\u95e8\u8bca\u6574\u5408\u8d85\u58f0\u3001\u5fc3\u7535\u3001\u5fc3\u6838\u78c1\u3001\u57fa\u56e0\u68c0\u6d4b\u53ca\u591a\u5b66\u79d1\u4f1a\u8bca\uff0c\u5f62\u6210”\u7b5b\u67e5\u3001\u7cbe\u51c6\u9274\u522b\u8bca\u65ad\u3001\u4e2a\u4f53\u5316\u6cbb\u7597\u3001\u7ec8\u8eab\u968f\u8bbf”\u4e00\u7ad9\u5f0f\u5168\u6d41\u7a0b\uff0c\u5e76\u901a\u8fc7\u8de8\u533a\u57df\u534f\u4f5c\u3001\u591a\u5c42\u7ea7\u57f9\u8bad\u548c\u6807\u51c6\u5316\u8bca\u7597\u8def\u5f84\uff0c\u63a8\u52a8\u89c4\u8303\u5316\u8bca\u7597\u6a21\u5f0f\u5411\u5168\u56fd\u63a8\u5e7f\u3002<\/p>\n

“\u5168\u7403\u9996\u521b”\u7a81\u7834\u6027\u7597\u6cd5\uff1a\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u63a8\u52a8\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u79d1\u5b66\u7a81\u7834<\/p>\n

\u5728\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\u7684\u5404\u7c7b\u8eab\u4f53\u6307\u6807\u4e2d\uff0c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u5f80\u5f80\u88ab\u5927\u4f17\u5ffd\u89c6\u3002\u7136\u800c\uff0cTG\u5f02\u5e38\u53ef\u80fd\u5f15\u53d1\u4e25\u91cd\u5371\u5bb3\u3002\u5f53TG\u503c\u9ad8\u4e8e5.6mmol\/L\u5373\u53ef\u5224\u522b\u4e3a\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08sHTG\uff09\uff0c\u5f53TG\u503c\u5927\u4e8e\u7b49\u4e8e10mmol\/L\u5e76\u7ed3\u5408\u5176\u4ed6\u8bca\u65ad\u6807\u51c6\uff0c\u5219\u53ef\u5224\u522b\u4e3a\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\uff08FCS\uff09*[13][14]\u3002\u76ee\u524d\uff0c\u6211\u56fd\u67091,700\u4e07\u60a3\u8005\u60a3\u6709sHTG[11]\u3002\u8fd9\u7c7b\u75be\u75c5\u5e38\u89c1\u5371\u5bb3\u662f\u6025\u6027\u80f0\u817a\u708e\uff0c\u60a3\u8005\u53ef\u80fd\u9762\u4e34\u4f4f\u9662\u751a\u81f3\u8fdb\u5165ICU\u7684\u98ce\u9669\uff0c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u6025\u6027\u80f0\u817a\u708e\u91cd\u75c7\u75c5\u6b7b\u7387\u53ef\u9ad8\u8fbe50%[12]\u3002<\/p>\n

\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u526f\u9662\u957f\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u7814\u7a76\u6240\u6240\u957f\u674e\u5efa\u5e73\u6559\u6388\u8868\u793a\uff1a”\u7518\u6cb9\u4e09\u916f\u662f\u4f53\u68c0\u62a5\u544a\u4e0a’\u6700\u719f\u6089\u7684\u964c\u751f\u4eba’\uff0c\u516c\u4f17\u5bf9\u4e8e\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u53ef\u80fd\u5f15\u53d1\u6025\u6027\u80f0\u817a\u708e\u5371\u5bb3\u8ba4\u77e5\u4e5f\u6709\u5f85\u63d0\u5347\u3002\u6025\u6027\u80f0\u817a\u708e\u53ef\u80fd\u8ba9\u60a3\u8005\u9762\u4e34\u5de8\u5927\u75db\u82e6\uff0c\u751a\u81f3\u6574\u4e2a\u5bb6\u5ead\u4e5f\u53ef\u80fd\u9762\u4e34\u91cd\u75c7\u76d1\u62a4\u7684\u538b\u529b\u3002\u5e76\u4e14\u4e00\u6b21\u6025\u6027\u80f0\u817a\u708e\u53d1\u4f5c\u5e76\u4e0d\u610f\u5473\u7740\u98ce\u9669\u5c31\u6b64\u7ed3\u675f\uff0c\u6025\u6027\u80f0\u817a\u708e\u5bb9\u6613\u53cd\u590d\u53d1\u4f5c\uff0c\u4e0d\u4ec5\u81f4\u6b7b\u98ce\u9669\u53e0\u52a0\uff0c\u7ecf\u6d4e\u538b\u529b\u4e5f\u5341\u5206\u6c89\u91cd\u3002\u56e0\u6b64\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7684\u7814\u7a76\u8fdb\u5c55\u5177\u6709\u5de8\u5927\u4ef7\u503c\u3002SHASTA-3\/4\u4e24\u98793\u671f\u5168\u7403\u7814\u7a76\u5171\u7eb3\u516585\u4f8b\u4e2d\u56fd\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\u666e\u4e50\u53f8\u5170\u80fd\u663e\u8457\u964d\u4f4e\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u548c\u6025\u6027\u80f0\u817a\u708e\u98ce\u9669\u3002\u5e0c\u671b\u501f\u52a9\u8fdb\u535a\u4f1a\u5f3a\u5927\u7684\u6ea2\u51fa\u6548\u5e94\uff0c\u63a8\u52a8\u8fd9\u4e00\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u65e9\u65e5\u6210\u4e3a\u60a3\u8005\u53ef\u53ca\u7684\u521b\u65b0\u5b9e\u8df5\u3002”<\/p>\n

\u672c\u6b21\u8fdb\u535a\u4f1a\u671f\u95f4\u53d1\u5e03\u7684\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7528\u4e8e\u6cbb\u7597\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08sHTG\uff093\u671f\u4e34\u5e8a\u7814\u7a76\u65b0\u6570\u636e\u663e\u793a\uff0c\u6cbb\u759712\u4e2a\u6708\u540e\uff0c\u60a3\u8005\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u964d\u4f4e79%\u81f381%\uff0c\u6025\u6027\u80f0\u817a\u708e\u53d1\u751f\u7387\u964d\u4f4e78%\uff0c\u5728TG\u22655.6 mmol\/L\u4e14\u65e2\u5f80\u6709\u6025\u6027\u80f0\u817a\u708e\u75c5\u53f2\u7684\u9ad8\u5371\u60a3\u8005\u4e2d\uff0c\u6025\u6027\u80f0\u817a\u708e\u590d\u53d1\u98ce\u9669\u964d\u4f4e91%\uff0c\u5728TG\u226510 mmol\/L\u4e14\u65e2\u5f80\u6709\u6025\u6027\u80f0\u817a\u708e\u75c5\u53f2\u7684\u6781\u9ad8\u5371\u60a3\u8005\u4e2d\uff0c\u590d\u53d1\u98ce\u9669\u964d\u4f4e100%[13]\u3002<\/p>\n

\u5357\u4eac\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u660e\u57fa\u533b\u9662\u5fc3\u8840\u7ba1\u5185\u79d1\u884c\u653f\u526f\u4e3b\u4efb\u90ed\u632f\u5cf0\u6559\u6388\u8868\u793a\uff1a”\u5728\u4e34\u5e8a\u4e2d\u6211\u4eec\u89c1\u8fc7\u8bb8\u591a\u56e0\u7518\u6cb9\u4e09\u916f\u8fc7\u9ad8\u8bf1\u53d1\u6025\u6027\u80f0\u817a\u708e\u7684\u60a3\u8005\uff0c\u5176\u7ecf\u53d7\u7684\u75bc\u75db\u88ab\u79f0\u4e3a’\u9876\u7ea7\u5267\u75db’\uff0c\u751a\u81f3\u8d85\u8fc7\u5206\u5a29\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u60a3\u8005\u65e5\u5e38\u751f\u6d3b\u8d28\u91cf\u4e5f\u53d7\u5230\u5de8\u5927\u5f71\u54cd\uff0c\u9700\u8981\u627f\u53d7\u4e25\u9177\u8282\u98df\uff0c\u5fc3\u7406\u8d1f\u62c5\u4e5f\u5341\u5206\u6c89\u91cd\u3002\u56e0\u6b64\uff0c\u63d0\u5347\u5927\u4f17\u5bf9\u4e8e\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u7684\u8ba4\u77e5\u81f3\u5173\u91cd\u8981\uff0c\u540c\u65f6\u5404\u754c\u529b\u91cf\u4e5f\u5e94\u643a\u624b\u5171\u540c\u63a8\u52a8\u7518\u6cb9\u4e09\u916f\u8fbe\u6807\u7ba1\u7406\uff0c\u7784\u51c65.6 mmol\/L\u4ee5\u4e0a\u7684\u9ad8\u5371\u7ea2\u7ebf\uff0c\u54111.7 mmol\/L\u5065\u5eb7\u7406\u60f3\u6807\u51c6\u770b\u9f50\uff0c\u5e76\u901a\u8fc7\u591a\u5b66\u79d1\u8054\u52a8\uff0c\u8ba9\u9ad8\u5371\u60a3\u8005\u4ece\u6025\u8bca\u6551\u6cbb\u8fc8\u5411\u65e9\u671f\u5e72\u9884\u3002”<\/p>\n

*\u60a3\u8005\u6807\u51c6\u964d\u8102\u7ba1\u7406\u540e\u7a7a\u8179\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u226510mmol\/L\uff0c\u4e14\u5408\u5e76\u4ee5\u4e0b\u56db\u9879\u6807\u51c6\u4e2d\u7684\u4efb\u610f\u4e00\u6761\u5373\u53ef\u8bca\u65ad\u4e3aFCS\u3002\u8fd9\u56db\u9879\u6807\u51c6\u5206\u522b\u662f\uff1aFCS\u76f8\u5173\u57fa\u56e0\u68c0\u6d4b\u9633\u6027\u3001\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u80f0\u817a\u708e\u5bb6\u65cf\u53f2\u3001\u9752\u5c11\u5e74\u80f0\u817a\u708e\u75c5\u53f2\u6216\u6210\u5e74\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u80f0\u817a\u708e\u75c5\u53f2\u3001\u4e0d\u660e\u539f\u56e0\u53cd\u590d\u8179\u75db\u4f4f\u9662\u75c5\u53f2[13][14]\u3002<\/p>\n

**\u963f\u592b\u51ef\u6cf0\u7247\u5728\u4e2d\u56fd\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ebd\u7ea6\u5fc3\u810f\u534f\u4f1a\uff08NYHA\uff09\u5fc3\u529f\u80fd\u5206\u7ea7II-III\u7ea7\u7684\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u4ee5\u6539\u5584\u8fd0\u52a8\u80fd\u529b\u548c\u75c7\u72b6\u3002\u975e\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u9002\u5e94\u75c7\u5c1a\u672a\u83b7\u6279\u3002<\/p>\n

***\u4e0a\u8ff0\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u4e0d\u6784\u6210\u5bf9\u4efb\u4f55\u836f\u7269\u6216\u8bca\u7597\u65b9\u6848\uff08\u5305\u62ec\u6b63\u5728\u5f00\u53d1\u7684\u836f\u7269\uff09\u7684\u63a8\u8350\u6216\u5ba3\u4f20\u3002\u6240\u542b\u4fe1\u606f\u4e0d\u5e94\u66ff\u4ee3\u4efb\u4f55\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u63d0\u4f9b\u7684\u533b\u7597\u5efa\u8bae\uff0c\u5177\u4f53\u533b\u7597\u76f8\u5173\u4e8b\u5b9c\u8bf7\u9075\u5faa\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u548c\u6307\u5bfc\u3002<\/p>\n

\n

[1] \u4efb\u7b11\u96e8,\u7530\u5e84,\u5f20\u6292\u626c. \u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\u548c\u4e34\u5e8a\u5e94\u7528[J]. \u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7,2025,53(9):1083-1088.<\/span><\/p>\n

[2] Masri A, et al. Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. N Engl J Med. Published online August 28, 2026.<\/span><\/p>\n

[3] \u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u5fc3\u808c\u75c5\u4e13\u79d1\u8054\u76df,\u4e2d\u56fd\u533b\u7597\u4fdd\u5065\u56fd\u9645\u4ea4\u6d41\u4fc3\u8fdb\u4f1a\u5fc3\u8840\u7ba1\u75c5\u7cbe\u51c6\u533b\u5b66\u5206\u4f1a”\u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u53572023″\u4e13\u5bb6\u7ec4. \u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u53572023[J]. \u4e2d\u56fd\u5faa\u73af\u6742\u5fd7,2023,38(1):1-33.<\/span><\/p>\n

[4] \u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e13\u5bb6\u59d4\u5458\u4f1a\u5fc3\u529b\u8870\u7aed\u4e13\u4e1a\u59d4\u5458\u4f1a,\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u5fc3\u529b\u8870\u7aed\u4e13\u4e1a\u59d4\u5458\u4f1a,\u4e2d\u534e\u533b\u5b66\u4f1a\u5fc3\u8840\u7ba1\u5206\u4f1a\u5fc3\u529b\u8870\u7aed\u5b66\u7ec4,\u7b49. \u4e2d\u56fd\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u6307\u53572022[J]. \u4e2d\u534e\u5fc3\u529b\u8870\u7aed\u548c\u5fc3\u808c\u75c5\u6742\u5fd7,2022,06(2):80-105.<\/span><\/p>\n

[5] Ommen SR, Ho CY, Asif IM, et al. 2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines[J]. Circulation. 2024 Jun 4;149(23):e1239-e1311<\/span><\/p>\n

[6] Masri A, Maron MS, Bhatia A, et al. Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy[J]. N Engl J Med. 2026. Online ahead of print. DOI: 10.1056\/NEJMoa2603021.<\/span><\/p>\n

[7] Elliott PM, Gimeno JR, Tom\u00e9 MT, et al. Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. European Heart Journal. 2006;27(16):1933\u20131941. DOI: 10.1093\/eurheartj\/ehl041.<\/span><\/p>\n

[8] \u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u5fc3\u808c\u75c5\u4e13\u79d1\u8054\u76df\u3001\u4e2d\u56fd\u533b\u7597\u4fdd\u5065\u56fd\u9645\u4ea4\u6d41\u4fc3\u8fdb\u4f1a\u5fc3\u8840\u7ba1\u75c5\u7cbe\u51c6\u533b\u5b66\u5206\u4f1a”\u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u53572023″\u4e13\u5bb6\u7ec4. \u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u53572023[J]. \u4e2d\u56fd\u5faa\u73af\u6742\u5fd7, 2023, 38(1): 1-33. DOI: 10.3969\/j.issn.1000-3614.2023.01.001<\/span><\/p>\n

[9] Coats CJ, et al. Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM. Journal of the American Heart Association. 2024;13(15):e035993. DOI: 10.1161\/JAHA.124.035993.<\/span><\/p>\n

[10] Maron MS, et al. Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy. New England Journal of Medicine. 2024;390(20):1849\u20131861. DOI:<\/span><\/p>\n

[11] Baass A, Paquette M, Lam O, Hofer K, Collet J, McClain MR. Prevalence, incidence, and definition of severe hypertriglyceridemia: A comprehensive review and weighted summary. J Clin Lipidol. 2025;19(6):1550-1563. doi:10.1016\/j.jacl.2025.08.012<\/span><\/p>\n

[12] \u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u6025\u6027\u80f0\u817a\u708e\u8bca\u6cbb\u6025\u8bca\u4e13\u5bb6\u5171\u8bc6\u3002\u300a\u4e2d\u56fd\u5168\u79d1\u533b\u5b66\u300b2021\u5e7410\u6708\u7b2c24\u5377\u7b2c30\u671f<\/span><\/p>\n

[13] \u8c22\u5764, \u4f0d\u838e, \u5510\u71a0\u8fbe, et al. \u4e2d\u56fd\u5bb6\u65cf\u6027\u9ad8\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u7279\u5f81\u53ca\u8bca\u65ad\u6807\u51c6\u63a2\u7d22 [J]. \u4e2d\u56fd\u5faa\u73af\u6742\u5fd7, 2024, 39(12): 1199-205.<\/span><\/p>\n

[14] \u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\u8bca\u65ad\u4e0e\u7ba1\u7406\u4e13\u5bb6\u5171\u8bc6\u7ec4. FCS\u8bca\u65ad\u4e0e\u7ba1\u7406\u4e13\u5bb6\u5171\u8bc6\u7b80\u62a5 [R]. the 20th Oriental Congress of Cardiology, 2026.<\/span><\/p>\n<\/div>\n

\n<\/div>\n

SOURCE \u8d5b\u8bfa\u83f2<\/p>","protected":false},"excerpt":{"rendered":"

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\u5728\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\u7684\u5404\u7c7b\u8eab\u4f53\u6307\u6807\u4e2d\uff0c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u5f80\u5f80\u88ab\u5927\u4f17\u5ffd\u89c6\u3002\u7136\u800c\uff0cTG\u5f02\u5e38\u53ef\u80fd\u5f15\u53d1\u4e25\u91cd\u5371\u5bb3\u3002\u5f53TG\u503c\u9ad8\u4e8e5.6mmol\/L\u5373\u53ef\u5224\u522b\u4e3a\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08sHTG\uff09\uff0c\u5f53TG\u503c\u5927\u4e8e\u7b49\u4e8e10mmol\/L\u5e76\u7ed3\u5408\u5176\u4ed6\u8bca\u65ad\u6807\u51c6\uff0c\u5219\u53ef\u5224\u522b\u4e3a\u5bb6\u65cf\u6027\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\u7efc\u5408\u5f81\uff08FCS\uff09*[13][14]\u3002\u76ee\u524d\uff0c\u6211\u56fd\u67091,700\u4e07\u60a3\u8005\u60a3\u6709sHTG[11]\u3002\u8fd9\u7c7b\u75be\u75c5\u5e38\u89c1\u5371\u5bb3\u662f\u6025\u6027\u80f0\u817a\u708e\uff0c\u60a3\u8005\u53ef\u80fd\u9762\u4e34\u4f4f\u9662\u751a\u81f3\u8fdb\u5165ICU\u7684\u98ce\u9669\uff0c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u6025\u6027\u80f0\u817a\u708e\u91cd\u75c7\u75c5\u6b7b\u7387\u53ef\u9ad8\u8fbe50%[12]\u3002 \u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u526f\u9662\u957f\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u7814\u7a76\u6240\u6240\u957f\u674e\u5efa\u5e73\u6559\u6388\u8868\u793a\uff1a”\u7518\u6cb9\u4e09\u916f\u662f\u4f53\u68c0\u62a5\u544a\u4e0a’\u6700\u719f\u6089\u7684\u964c\u751f\u4eba’\uff0c\u516c\u4f17\u5bf9\u4e8e\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u53ef\u80fd\u5f15\u53d1\u6025\u6027\u80f0\u817a\u708e\u5371\u5bb3\u8ba4\u77e5\u4e5f\u6709\u5f85\u63d0\u5347\u3002\u6025\u6027\u80f0\u817a\u708e\u53ef\u80fd\u8ba9\u60a3\u8005\u9762\u4e34\u5de8\u5927\u75db\u82e6\uff0c\u751a\u81f3\u6574\u4e2a\u5bb6\u5ead\u4e5f\u53ef\u80fd\u9762\u4e34\u91cd\u75c7\u76d1\u62a4\u7684\u538b\u529b\u3002\u5e76\u4e14\u4e00\u6b21\u6025\u6027\u80f0\u817a\u708e\u53d1\u4f5c\u5e76\u4e0d\u610f\u5473\u7740\u98ce\u9669\u5c31\u6b64\u7ed3\u675f\uff0c\u6025\u6027\u80f0\u817a\u708e\u5bb9\u6613\u53cd\u590d\u53d1\u4f5c\uff0c\u4e0d\u4ec5\u81f4\u6b7b\u98ce\u9669\u53e0\u52a0\uff0c\u7ecf\u6d4e\u538b\u529b\u4e5f\u5341\u5206\u6c89\u91cd\u3002\u56e0\u6b64\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7684\u7814\u7a76\u8fdb\u5c55\u5177\u6709\u5de8\u5927\u4ef7\u503c\u3002SHASTA-3\/4\u4e24\u98793\u671f\u5168\u7403\u7814\u7a76\u5171\u7eb3\u516585\u4f8b\u4e2d\u56fd\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\u666e\u4e50\u53f8\u5170\u80fd\u663e\u8457\u964d\u4f4e\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u548c\u6025\u6027\u80f0\u817a\u708e\u98ce\u9669\u3002\u5e0c\u671b\u501f\u52a9\u8fdb\u535a\u4f1a\u5f3a\u5927\u7684\u6ea2\u51fa\u6548\u5e94\uff0c\u63a8\u52a8\u8fd9\u4e00\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u65e9\u65e5\u6210\u4e3a\u60a3\u8005\u53ef\u53ca\u7684\u521b\u65b0\u5b9e\u8df5\u3002” \u672c\u6b21\u8fdb\u535a\u4f1a\u671f\u95f4\u53d1\u5e03\u7684\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7528\u4e8e\u6cbb\u7597\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08sHTG\uff093\u671f\u4e34\u5e8a\u7814\u7a76\u65b0\u6570\u636e\u663e\u793a\uff0c\u6cbb\u759712\u4e2a\u6708\u540e\uff0c\u60a3\u8005\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u964d\u4f4e79%\u81f381%\uff0c\u6025\u6027\u80f0\u817a\u708e\u53d1\u751f\u7387\u964d\u4f4e78%\uff0c\u5728TG\u22655.6 mmol\/L\u4e14\u65e2\u5f80\u6709\u6025\u6027\u80f0\u817a\u708e\u75c5\u53f2\u7684\u9ad8\u5371\u60a3\u8005\u4e2d\uff0c\u6025\u6027\u80f0\u817a\u708e\u590d\u53d1\u98ce\u9669\u964d\u4f4e91%\uff0c\u5728TG\u226510 mmol\/L\u4e14\u65e2\u5f80\u6709\u6025\u6027\u80f0\u817a\u708e\u75c5\u53f2\u7684\u6781\u9ad8\u5371\u60a3\u8005\u4e2d\uff0c\u590d\u53d1\u98ce\u9669\u964d\u4f4e100%[13]\u3002 \u5357\u4eac\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u660e\u57fa\u533b\u9662\u5fc3\u8840\u7ba1\u5185\u79d1\u884c\u653f\u526f\u4e3b\u4efb\u90ed\u632f\u5cf0\u6559\u6388\u8868\u793a\uff1a”\u5728\u4e34\u5e8a\u4e2d\u6211\u4eec\u89c1\u8fc7\u8bb8\u591a\u56e0\u7518\u6cb9\u4e09\u916f\u8fc7\u9ad8\u8bf1\u53d1\u6025\u6027\u80f0\u817a\u708e\u7684\u60a3\u8005\uff0c\u5176\u7ecf\u53d7\u7684\u75bc\u75db\u88ab\u79f0\u4e3a’\u9876\u7ea7\u5267\u75db’\uff0c\u751a\u81f3\u8d85\u8fc7\u5206\u5a29\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u60a3\u8005\u65e5\u5e38\u751f\u6d3b\u8d28\u91cf\u4e5f\u53d7\u5230\u5de8\u5927\u5f71\u54cd\uff0c\u9700\u8981\u627f\u53d7\u4e25\u9177\u8282\u98df\uff0c\u5fc3\u7406\u8d1f\u62c5\u4e5f\u5341\u5206\u6c89\u91cd\u3002\u56e0\u6b64\uff0c\u63d0\u5347\u5927\u4f17\u5bf9\u4e8e\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u7684\u8ba4\u77e5\u81f3\u5173\u91cd\u8981\uff0c\u540c\u65f6\u5404\u754c\u529b\u91cf\u4e5f\u5e94\u643a\u624b\u5171\u540c\u63a8\u52a8\u7518\u6cb9\u4e09\u916f\u8fbe\u6807\u7ba1\u7406\uff0c\u7784\u51c65.6 mmol\/L\u4ee5\u4e0a\u7684\u9ad8\u5371\u7ea2\u7ebf\uff0c\u54111.7 mmol\/L\u5065\u5eb7\u7406\u60f3\u6807\u51c6\u770b\u9f50\uff0c\u5e76\u901a\u8fc7\u591a\u5b66\u79d1\u8054\u52a8\uff0c\u8ba9\u9ad8\u5371\u60a3\u8005\u4ece\u6025\u8bca\u6551\u6cbb\u8fc8\u5411\u65e9\u671f\u5e72\u9884\u3002” *\u60a3\u8005\u6807\u51c6\u964d\u8102\u7ba1\u7406\u540e\u7a7a\u8179\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u226510mmol\/L\uff0c\u4e14\u5408\u5e76\u4ee5\u4e0b\u56db\u9879\u6807\u51c6\u4e2d\u7684\u4efb\u610f\u4e00\u6761\u5373\u53ef\u8bca\u65ad\u4e3aFCS\u3002\u8fd9\u56db\u9879\u6807\u51c6\u5206\u522b\u662f\uff1aFCS\u76f8\u5173\u57fa\u56e0\u68c0\u6d4b\u9633\u6027\u3001\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u80f0\u817a\u708e\u5bb6\u65cf\u53f2\u3001\u9752\u5c11\u5e74\u80f0\u817a\u708e\u75c5\u53f2\u6216\u6210\u5e74\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u80f0\u817a\u708e\u75c5\u53f2\u3001\u4e0d\u660e\u539f\u56e0\u53cd\u590d\u8179\u75db\u4f4f\u9662\u75c5\u53f2[13][14]\u3002 **\u963f\u592b\u51ef\u6cf0\u7247\u5728\u4e2d\u56fd\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ebd\u7ea6\u5fc3\u810f\u534f\u4f1a\uff08NYHA\uff09\u5fc3\u529f\u80fd\u5206\u7ea7II-III\u7ea7\u7684\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u4ee5\u6539\u5584\u8fd0\u52a8\u80fd\u529b\u548c\u75c7\u72b6\u3002\u975e\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u9002\u5e94\u75c7\u5c1a\u672a\u83b7\u6279\u3002 ***\u4e0a\u8ff0\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u4e0d\u6784\u6210\u5bf9\u4efb\u4f55\u836f\u7269\u6216\u8bca\u7597\u65b9\u6848\uff08\u5305\u62ec\u6b63\u5728\u5f00\u53d1\u7684\u836f\u7269\uff09\u7684\u63a8\u8350\u6216\u5ba3\u4f20\u3002\u6240\u542b\u4fe1\u606f\u4e0d\u5e94\u66ff\u4ee3\u4efb\u4f55\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u63d0\u4f9b\u7684\u533b\u7597\u5efa\u8bae\uff0c\u5177\u4f53\u533b\u7597\u76f8\u5173\u4e8b\u5b9c\u8bf7\u9075\u5faa\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u548c\u6307\u5bfc\u3002 [1] \u4efb\u7b11\u96e8,\u7530\u5e84,\u5f20\u6292\u626c. \u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\u548c\u4e34\u5e8a\u5e94\u7528[J]. \u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7,2025,53(9):1083-1088. [2] Masri A, et al. Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. N Engl J Med. 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\u672c\u6b21\u8fdb\u535a\u4f1a\u671f\u95f4\u53d1\u5e03\u7684\u666e\u4e50\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\u7528\u4e8e\u6cbb\u7597\u91cd\u5ea6\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08sHTG\uff093\u671f\u4e34\u5e8a\u7814\u7a76\u65b0\u6570\u636e\u663e\u793a\uff0c\u6cbb\u759712\u4e2a\u6708\u540e\uff0c\u60a3\u8005\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u964d\u4f4e79%\u81f381%\uff0c\u6025\u6027\u80f0\u817a\u708e\u53d1\u751f\u7387\u964d\u4f4e78%\uff0c\u5728TG\u22655.6 mmol\/L\u4e14\u65e2\u5f80\u6709\u6025\u6027\u80f0\u817a\u708e\u75c5\u53f2\u7684\u9ad8\u5371\u60a3\u8005\u4e2d\uff0c\u6025\u6027\u80f0\u817a\u708e\u590d\u53d1\u98ce\u9669\u964d\u4f4e91%\uff0c\u5728TG\u226510 mmol\/L\u4e14\u65e2\u5f80\u6709\u6025\u6027\u80f0\u817a\u708e\u75c5\u53f2\u7684\u6781\u9ad8\u5371\u60a3\u8005\u4e2d\uff0c\u590d\u53d1\u98ce\u9669\u964d\u4f4e100%[13]\u3002 \u5357\u4eac\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u660e\u57fa\u533b\u9662\u5fc3\u8840\u7ba1\u5185\u79d1\u884c\u653f\u526f\u4e3b\u4efb\u90ed\u632f\u5cf0\u6559\u6388\u8868\u793a\uff1a”\u5728\u4e34\u5e8a\u4e2d\u6211\u4eec\u89c1\u8fc7\u8bb8\u591a\u56e0\u7518\u6cb9\u4e09\u916f\u8fc7\u9ad8\u8bf1\u53d1\u6025\u6027\u80f0\u817a\u708e\u7684\u60a3\u8005\uff0c\u5176\u7ecf\u53d7\u7684\u75bc\u75db\u88ab\u79f0\u4e3a’\u9876\u7ea7\u5267\u75db’\uff0c\u751a\u81f3\u8d85\u8fc7\u5206\u5a29\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u60a3\u8005\u65e5\u5e38\u751f\u6d3b\u8d28\u91cf\u4e5f\u53d7\u5230\u5de8\u5927\u5f71\u54cd\uff0c\u9700\u8981\u627f\u53d7\u4e25\u9177\u8282\u98df\uff0c\u5fc3\u7406\u8d1f\u62c5\u4e5f\u5341\u5206\u6c89\u91cd\u3002\u56e0\u6b64\uff0c\u63d0\u5347\u5927\u4f17\u5bf9\u4e8e\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u7684\u8ba4\u77e5\u81f3\u5173\u91cd\u8981\uff0c\u540c\u65f6\u5404\u754c\u529b\u91cf\u4e5f\u5e94\u643a\u624b\u5171\u540c\u63a8\u52a8\u7518\u6cb9\u4e09\u916f\u8fbe\u6807\u7ba1\u7406\uff0c\u7784\u51c65.6 mmol\/L\u4ee5\u4e0a\u7684\u9ad8\u5371\u7ea2\u7ebf\uff0c\u54111.7 mmol\/L\u5065\u5eb7\u7406\u60f3\u6807\u51c6\u770b\u9f50\uff0c\u5e76\u901a\u8fc7\u591a\u5b66\u79d1\u8054\u52a8\uff0c\u8ba9\u9ad8\u5371\u60a3\u8005\u4ece\u6025\u8bca\u6551\u6cbb\u8fc8\u5411\u65e9\u671f\u5e72\u9884\u3002” *\u60a3\u8005\u6807\u51c6\u964d\u8102\u7ba1\u7406\u540e\u7a7a\u8179\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u226510mmol\/L\uff0c\u4e14\u5408\u5e76\u4ee5\u4e0b\u56db\u9879\u6807\u51c6\u4e2d\u7684\u4efb\u610f\u4e00\u6761\u5373\u53ef\u8bca\u65ad\u4e3aFCS\u3002\u8fd9\u56db\u9879\u6807\u51c6\u5206\u522b\u662f\uff1aFCS\u76f8\u5173\u57fa\u56e0\u68c0\u6d4b\u9633\u6027\u3001\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u80f0\u817a\u708e\u5bb6\u65cf\u53f2\u3001\u9752\u5c11\u5e74\u80f0\u817a\u708e\u75c5\u53f2\u6216\u6210\u5e74\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u6027\u80f0\u817a\u708e\u75c5\u53f2\u3001\u4e0d\u660e\u539f\u56e0\u53cd\u590d\u8179\u75db\u4f4f\u9662\u75c5\u53f2[13][14]\u3002 **\u963f\u592b\u51ef\u6cf0\u7247\u5728\u4e2d\u56fd\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ebd\u7ea6\u5fc3\u810f\u534f\u4f1a\uff08NYHA\uff09\u5fc3\u529f\u80fd\u5206\u7ea7II-III\u7ea7\u7684\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u4ee5\u6539\u5584\u8fd0\u52a8\u80fd\u529b\u548c\u75c7\u72b6\u3002\u975e\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u9002\u5e94\u75c7\u5c1a\u672a\u83b7\u6279\u3002 ***\u4e0a\u8ff0\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u4e0d\u6784\u6210\u5bf9\u4efb\u4f55\u836f\u7269\u6216\u8bca\u7597\u65b9\u6848\uff08\u5305\u62ec\u6b63\u5728\u5f00\u53d1\u7684\u836f\u7269\uff09\u7684\u63a8\u8350\u6216\u5ba3\u4f20\u3002\u6240\u542b\u4fe1\u606f\u4e0d\u5e94\u66ff\u4ee3\u4efb\u4f55\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u63d0\u4f9b\u7684\u533b\u7597\u5efa\u8bae\uff0c\u5177\u4f53\u533b\u7597\u76f8\u5173\u4e8b\u5b9c\u8bf7\u9075\u5faa\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u548c\u6307\u5bfc\u3002 [1] \u4efb\u7b11\u96e8,\u7530\u5e84,\u5f20\u6292\u626c. \u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\u548c\u4e34\u5e8a\u5e94\u7528[J]. \u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7,2025,53(9):1083-1088. [2] Masri A, et al. Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. N Engl J Med. 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[2] Masri A, et al. Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. N Engl J Med. 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