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\n<\/div>\n

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\n<\/div>\n

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\u6b64\u5916\uff0c\u4e2d\u56fd\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u53d1\u75c5\u5e74\u9f84\u76f8\u5bf9\u8f83\u8f7b[3]\uff0c\u591a\u5904\u4e8e\u627f\u62c5\u91cd\u8981\u5bb6\u5ead\u4e0e\u793e\u4f1a\u8d23\u4efb\u7684\u4eba\u751f\u9636\u6bb5\uff0c\u56de\u5f52\u6b63\u5e38\u751f\u6d3b\u7684\u9700\u6c42\u5c24\u4e3a\u8feb\u5207\u3002\u5728\u6709\u6548\u964d\u4f4e\u590d\u53d1\u98ce\u9669\u7684\u540c\u65f6\uff0c\u5e2e\u52a9\u60a3\u8005\u575a\u6301\u89c4\u8303\u6cbb\u7597\u3001\u505a\u597d\u957f\u671f\u968f\u8bbf\u5e76\u56de\u5f52\u9ad8\u8d28\u91cf\u751f\u6d3b\uff0c\u4ecd\u662fHR+\u4e73\u817a\u764c\u9886\u57df\u4e9f\u5f85\u6ee1\u8db3\u7684\u9700\u6c42\u3002<\/p>\n

\u591a\u65b9\u5171\u8bdd”\u4e09\u5e74\u575a\u6301”\uff0c\u643a\u624b\u63a5\u529b\u957f\u671f\u7ba1\u7406<\/p>\n

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\n<\/div>\n

\u4e13\u5bb6\u4eec\u5728\u672c\u6b21\u6d3b\u52a8\u4e0a\u5f3a\u8c03\uff0c\u4e73\u817a\u764c\u7684\u957f\u671f\u7ba1\u7406\u662f\u4e00\u573a\u9700\u8981\u4e34\u5e8a\u3001\u516c\u76ca\u7ec4\u7ec7\u3001\u96f6\u552e\u4e0e\u4f01\u4e1a\u5171\u540c\u63a5\u529b\u7684”\u957f\u8dd1”\uff1a\u4ece\u672f\u540e\u524d3\u5e74\u7684\u590d\u53d1\u98ce\u9669\uff0c\u5230\u8db3\u5242\u91cf\u3001\u8db3\u7597\u7a0b\u4e0e\u89c4\u5f8b\u968f\u8bbf\uff0c\u518d\u5230\u9662\u5916\u7528\u836f\u63d0\u9192\u4e0e\u987a\u7545\u8f6c\u4ecb\uff0c\u4efb\u4f55\u4e00\u4e2a\u73af\u8282\u7684\u677e\u52a8\uff0c\u90fd\u53ef\u80fd\u5f71\u54cd\u60a3\u8005\u8d70\u5411\u6cbb\u6108\u7684\u6b65\u4f10\u3002<\/p>\n

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\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u9676\u601d\u4e30\u6559\u6388\u8868\u793a\uff1a”\u6700\u65b0\u516c\u5e03\u7684NATALEE\u7814\u7a76\u516d\u5e74\u968f\u8bbf\u6570\u636e\u663e\u793a\uff0c\u5728II\u671f\u548cIII\u671f\u9ad8\u590d\u53d1\u98ce\u9669HR+\/HER2-\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0cCDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u8f83\u5355\u7528\u5185\u5206\u6ccc\u6cbb\u7597\u964d\u4f4e\u6b7b\u4ea1\u98ce\u9669\uff0c\u6269\u5927\u603b\u751f\u5b58\u7edd\u5bf9\u83b7\u76ca [6]\u3002\u957f\u671fOS\u6570\u636e\u8bf4\u660e\u51cf\u5c11\u590d\u53d1\u80fd\u8f6c\u5316\u4e3a\u6d3b\u5f97\u66f4\u4e45\uff0c\u4f46\u9009\u5bf9\u65b9\u6848\u53ea\u662f\u7b2c\u4e00\u6b65\u3002\u5173\u952e\u662f\u8db3\u5242\u91cf\u3001\u8db3\u7597\u7a0b\u3001\u89c4\u5f8b\u968f\u8bbf\uff0c\u9996\u5e74\u6309\u8282\u70b9\u56de\u9662\uff0c\u4e0d\u9002\u53ca\u65f6\u5904\u7406\u3002”<\/p>\n

\u5317\u4eac\u9f0e\u533b\u516c\u76ca\u57fa\u91d1\u4f1a\u79d8\u4e66\u957f\u9a6c\u6d77\u4f1f\u4ecb\u7ecd\uff1a”\u57fa\u91d1\u4f1aCDK4\/6\u60a3\u8005\u7ba1\u7406\u9879\u76ee\u901a\u8fc7\u7535\u8bdd\u968f\u8bbf\u63d0\u9192\u7528\u836f\u3001\u8bc6\u522b\u4e0d\u826f\u53cd\u5e94\u548c\u590d\u8bca\u3002\u9879\u76ee\u4e0d\u66ff\u4ee3\u533b\u751f\u8bca\u7597\uff0c\u53ea\u505a\u63d0\u9192\u548c\u8f85\u52a9\uff0c\u8ba9\u60a3\u8005\u611f\u89c9’\u6709\u4eba\u8bb0\u7740\u6211’\u3002”<\/p>\n

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\u53c2\u8003\u6587\u732e<\/p>\n

\n

[1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.<\/span><\/p>\n

[2] \u90d1\u8363\u5bff, \u9648\u8339, \u97e9\u51b0\u5cf0, \u7b49. 2022\u5e74\u4e2d\u56fd\u6076\u6027\u80bf\u7624\u6d41\u884c\u60c5\u51b5\u5206\u6790[J]. \u4e2d\u534e\u80bf\u7624\u6742\u5fd7, 2024, 46(3): 221-231.<\/span><\/p>\n

[3] \u56fd\u5bb6\u80bf\u7624\u8d28\u63a7\u4e2d\u5fc3\u4e73\u817a\u764c\u4e13\u5bb6\u59d4\u5458\u4f1a, \u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u4e13\u4e1a\u59d4\u5458\u4f1a, \u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u4e73\u817a\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a. HR+\/HER-2-\u65e9\u671f\u4e73\u817a\u764c\u590d\u53d1\u98ce\u9669\u4e0e\u4e34\u5e8a\u7ba1\u7406\u4e13\u5bb6\u5171\u8bc6\uff082025\u7248\uff09[J]. \u4e2d\u534e\u80bf\u7624\u6742\u5fd7, 2025, 47(7): 599-616.<\/span><\/p>\n

[4] Pan H, Gray R, Braybrooke J, et al. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years[J]. N Engl J Med, 2017, 377(19): 1836-1846.<\/span><\/p>\n

[5] Slamon D, Lipatov O, Nowecki Z, et al. Ribociclib plus Endocrine Therapy in Early Breast Cancer[J]. N Engl J Med, 2024, 390(12): 1080-1091.<\/span><\/p>\n

[6] Slamon DJ, et al. Overall survival with adjuvant ribociclib plus nonsteroidal aromatase inhibitor in patients with high-risk HR+\/HER2\u2013 early breast cancer: Six-year follow-up of the NATALEE trial[J]. Ann Oncol, 2026. Published online October 23, 2026.<\/span><\/p>\n<\/div>\n

\n<\/div>\n

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\u53c2\u8003\u6587\u732e [1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263. 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\u53c2\u8003\u6587\u732e [1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263. 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\u53c2\u8003\u6587\u732e [1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263. 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