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Oncology\u53d1\u8868\uff0c\u6b64\u9879\u9488\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc73\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684R\/RMM\u60a3\u8005\u7684\u7814\u7a76\u7ed3\u679c\u4ee4\u4eba\u632f\u594b\u3002\u611f\u8c22FUMANBA-1\u7814\u7a76\u56e2\u961f\u4e25\u8c28\u7684\u79d1\u5b66\u6001\u5ea6\u548c\u9ad8\u6807\u51c6\u7684\u6267\u884c\u3002\u76ee\u524d\uff0c\u9a6f\u9e7f\u751f\u7269\u4e5f\u6b63\u5728\u79ef\u6781\u5f00\u5c55\u548c\u63a8\u8fdb\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u524d\u7ebf\u9002\u5e94\u75c7\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc71-2\u7ebf\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624(MM)\u60a3\u8005\u7684III\u671f\u4e34\u5e8a\u7814\u7a76FUMANBA-3\uff0c\u6211\u4eec\u975e\u5e38\u671f\u5f85\u8fd9\u4e9b\u57fa\u4e8e\u4e2d\u56fd\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\u80fd\u591f\u65e9\u65e5\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u5c3d\u65e9\u8ba9\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u670d\u52a1\u4e8e\u66f4\u591a\u60a3\u8005\uff0c\u4e3a\u4ed6\u4eec\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002&#8221;<\/p>\n<p>###<\/p>\n<p>\u5173\u4e8eFUMANBA-1\u7814\u7a76<\/p>\n<p>FUMANBA-1\u662f\u4e00\u9879\u5355\u81c2\u3001\u5f00\u653e\u6807\u7b7e\u76841b\/2\u671f\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u572814\u5bb6\u4e2d\u5fc3\u5f00\u5c55\uff0c\u65e8\u5728\u8bc4\u4f30\u5168\u4eba\u6e90\u9776\u5411BCMA CAR-T\u7ec6\u80de\u7597\u6cd5\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u5728\u65e2\u5f80\u63a5\u53d7\u8fc73\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08R\/RMM\uff09\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u5165\u7ec4\u8be5\u8bd5\u9a8c\u7684\u4e3a\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c113\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\uff08\u5305\u542b\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u548c\u514d\u75ab\u8c03\u8282\u5242\u4e3a\u57fa\u7840\u7684\u5316\u7597\u65b9\u6848\uff09\u4e14\u672b\u7ebf\u8fdb\u5c55\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7BCMA CAR-T\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u4e5f\u53ef\u5165\u7ec4\u3002<\/p>\n<p>\u5173\u4e8e\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2<\/p>\n<p>\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\u662f\u4e00\u79cd\u9488\u5bf9B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u4ee5\u6162\u75c5\u6bd2\u4e3a\u57fa\u56e0\u8f7d\u4f53\u8f6c\u67d3\u81ea\u4f53T\u7ec6\u80de\uff0cCAR\u5305\u542b\u5168\u4eba\u6e90scFv\u3001CD8a 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CAR-T\u4ea7\u54c1\uff09\u5df2\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u5e76\u5df2\u83b7\u5f97\u7f8e\u56fdFDA\u8bb8\u53ef\u5f00\u5c55\u6ce8\u518c\u4e34\u5e8a\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/p>\n<p>\u9a6f\u9e7f\u751f\u7269\u51ed\u501f\u5176\u5f3a\u5927\u7684\u7ba1\u7406\u56e2\u961f\u3001\u521b\u65b0\u7684\u4ea7\u54c1\u7ebf\u3001\u81ea\u6709\u7684GMP\u751f\u4ea7\u548c\u8d85\u5f3a\u7684\u4e34\u5e8a\u5f00\u53d1\u80fd\u529b\uff0c\u65e8\u5728\u63d0\u4f9b\u53d8\u9769\u6027\u3001\u53ef\u6cbb\u6108\u7684\u521b\u65b0\u578b\u7597\u6cd5\uff0c\u4e3a\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5e26\u6765\u6cbb\u6108\u7684\u5e0c\u671b\u3002<\/p>\n<p>\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u5b98\u7f51\uff1a<a href=\"https:\/\/www.iasobio.com\/\" target=\"_blank\" rel=\"noopener\">www.iasobio.com<\/a>\u6216\u9886\u82f1\u8d26\u53f7\uff1a<a href=\"https:\/\/www.linkedin.com\/company\/iasobiotherapeutics\" target=\"_blank\" rel=\"noopener\">www.linkedin.com\/company\/iasobiotherapeutics<\/a>\u3002<\/p>\n<p>SOURCE  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Oncology\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u5728\u65e2\u5f80\u63a5\u53d7\u8fc73\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684R\/RMM\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u7ed3\u679c\u663e\u793a\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u5728R\/RMM\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u9ad8\u603b\u4f53\u7f13\u89e3\u7387\u548c\u6301\u4e45\u7f13\u89e3\uff0c\u540c\u65f6\u5b89\u5168\u6027\u826f\u597d\u3002 \u6b64\u6b21JAMA 0ncology\u53d1\u8868\u4e86\u622a\u81f32022\u5e749\u67089\u65e5\u5171103\u4f8b\u53d7\u8bd5\u8005\u63a5\u53d7\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u56de\u8f93\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u53d7\u8bd5\u8005\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a13.8\uff08\u8303\u56f4 0.4-27.2\uff09\u4e2a\u6708\u3002\u7597\u6548\u65b9\u9762\uff0c\u5728\u7597\u6548\u53ef\u8bc4\u4f30\u7684101\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a 96.0%\uff0897\/101\uff09\u3002\u4e25\u683c\u610f\u4e49\u7684\u5b8c\u5168\u7f13\u89e3\/\u5b8c\u5168\u7f13\u89e3\u7387\uff08sCR\/CR\uff09\u4e3a74.3%\uff0875\/101\uff09\u3002\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7CAR-T\u6cbb\u7597\u768489\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0cORR\u4e3a98.9%\uff0888\/89\uff09\uff0cCR\/sCR\u7387\u4e3a78.7%\uff0870\/89\uff09\u3002\u5728\u8fd9101\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c\u4e2d\u4f4d\u8fbe\u7f13\u89e3\u65f6\u95f4\u4e3a16\u5929\uff08\u8303\u56f411-179\uff09\uff0c\u4e2d\u4f4d\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DOR\uff09\u548c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5747\u672a\u8fbe\u5230\uff0c12\u4e2a\u6708\u7684PFS\u7387\u4e3a78.8%\uff0895% CI: 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### \u5173\u4e8eFUMANBA-1\u7814\u7a76 FUMANBA-1\u662f\u4e00\u9879\u5355\u81c2\u3001\u5f00\u653e\u6807\u7b7e\u76841b\/2\u671f\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u572814\u5bb6\u4e2d\u5fc3\u5f00\u5c55\uff0c\u65e8\u5728\u8bc4\u4f30\u5168\u4eba\u6e90\u9776\u5411BCMA 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\u9a6f\u9e7f\u751f\u7269\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u7ec6\u80de\u521b\u65b0\u836f\u7269\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u516c\u53f8\u4ee5\u5f00\u53d1\u8840\u6db2\u80bf\u7624\u7ec6\u80de\u7c7b\u836f\u7269\u548c\u6297\u4f53\u836f\u7269\u4e3a\u521b\u65b0\u57fa\u77f3\uff0c\u5411\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u62d3\u5c55\uff0c\u62e5\u6709\u5b8c\u6574\u7684\u4ece\u65e9\u671f\u53d1\u73b0\u3001\u4e34\u5e8a\u5f00\u53d1\u3001\u6ce8\u518c\u7533\u62a5\u5230\u5546\u4e1a\u5316\u751f\u4ea7\u7684\u5168\u6d41\u7a0b\u80fd\u529b\u3002 \u516c\u53f8\u73b0\u670910\u4f59\u4e2a\u5904\u4e8e\u4e0d\u540c\u7814\u53d1\u9636\u6bb5\u7684\u521b\u65b0\u836f\u7269\u54c1\u79cd\uff0c\u5176\u4e2d\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u5168\u4eba\u6e90BCMA 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\u9a6f\u9e7f\u751f\u7269<\/p>\n","protected":false},"author":0,"featured_media":3916,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-3915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>JAMA Oncology \u53d1\u8868\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u76241b\/2\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/jama-oncology-\u53d1\u8868\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\uff09\u7528\u4e8e\u6cbb\u7597\u590d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JAMA Oncology \u53d1\u8868\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u76241b\/2\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u2014\u20141b\/2\u671fFUMANBA-1\u7814\u7a76\u6570\u636e\u8bc1\u660e\uff0c\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\u5728\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u5b9e\u73b0\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7f13\u89e3\uff1b\u2014\u2014\u6570\u636e\u663e\u793a\uff0c\u6cbb\u7597\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a96.0%\uff0c\u5176\u4e2d\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7CAR-T\u6cbb\u7597\u53d7\u8bd5\u8005\u7684ORR\u4e3a98.9%\uff1b\u2014\u2014103\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c\u4ec5\u4e00\u4f8b\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u65e03\u7ea7\u4ee5\u4e0a\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\u7efc\u5408\u5f81\uff08ICANS\uff09\u53d1\u751f \u4e2d\u56fd\u5357\u4eac\u3001\u4e0a\u6d77\u548c\u52a0\u5dde\u5723\u8377\u897f2024\u5e7411\u67088\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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