{"id":4520,"date":"2024-11-19T11:30:00","date_gmt":"2024-11-19T11:30:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e9%a6%96%e6%ac%a1%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9b%bd%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%ad%a6%e4%bc%9a-aasld-%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%8f%91\/"},"modified":"2024-11-19T11:30:00","modified_gmt":"2024-11-19T11:30:00","slug":"%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e9%a6%96%e6%ac%a1%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9b%bd%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%ad%a6%e4%bc%9a-aasld-%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%8f%91","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e9%a6%96%e6%ac%a1%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9b%bd%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%ad%a6%e4%bc%9a-aasld-%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%8f%91\/","title":{"rendered":"\u817e\u76db\u535a\u836f\u9996\u6b21\u57282024\u5e74\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a (AASLD) \u5e74\u4f1a\u4e0a\u53d1\u5e03siRNA (Elebsiran) \u8054\u5408PEG-IFN\u03b1 \u5bf9\u6bd4PEG-IFN\u03b1 \u5355\u836f\u6cbb\u7597\u7684\u7ed3\u679c\uff0c\u8bc1\u660e\u8054\u5408siRNA\u53ef\u66f4\u663e\u8457\u63d0\u9ad8HBV\u8868\u9762\u6297\u539f\u6e05\u9664"},"content":{"rendered":"

\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u63d0\u4f9b\u768448\u5468\u6cbb\u7597\u7ed3\u675f\u6570\u636e\u6e05\u695a\u5730\u8868\u660e\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u53ef\u5b9e\u73b0\u66f4\u591a\u83b7\u76ca\uff0c\u4ece\u800c\u83b7\u5f97\u66f4\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387<\/p>\n

\u7531\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u5f00\u5c55\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\u6570\u636e\u5c06\u7ee7\u7eed\u652f\u6301\u516c\u53f8\u7684\u7b56\u7565\uff0c\u5373\u901a\u8fc7\u6b63\u786e\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u5b9e\u73b0HBV\u529f\u80fd\u6027\u6cbb\u6108<\/p>\n

\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c6<\/span>2024\u5e7411\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08”\u817e\u76db\u535a\u836f”\u6216”\u516c\u53f8”\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u533b\u7597\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u572811\u670815\u65e5\u81f319\u65e5\u4e8e\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u5730\u4e9a\u54e5\u4e3e\u884c\u7684\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a\uff08AASLD\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\uff08late-breaking\uff09\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\u3002<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

ENSURE\u662f\u4e00\u9879\u9633\u6027\u5bf9\u7167\u3001\u968f\u673a\u30012\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u8bd5\u9a8c\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09elebsiran\uff08BRII-835\uff0cVIR-2218\uff09\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5bf9\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u57fa\u7ebf\u4e3a100-3,000 IU\/mL\u7684\u6162\u6027HBV\u611f\u67d3\u8005\u7684\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u6392\u9664\u4e86HBsAg\u57fa\u7ebf\u6c34\u5e73\u8f83\u4f4e\uff08<100 IU\/mL\uff09\u7684HBV\u60a3\u8005\uff0c\u4ee5\u7814\u7a76\u5728\u66f4\u5e7f\u6cdb\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u6f5c\u5728\u7597\u6548\u3002ENSURE 48\u5468\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u6570\u636e\u663e\u793a\uff0c\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u63a5\u53d7200 mg\u6216100 mg elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u5206\u522b\u670926.3%\uff085\/19\uff09\u621633.3%\uff086\/18\uff09\u5b9e\u73b0HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u63a5\u53d7PEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u53ea\u67095.6%\uff081\/18\uff09\u5b9e\u73b0HBsAg\u8840\u6e05\u6e05\u9664\u3002<\/p>\n

\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb\u8d3e\u7ee7\u4e1c\u6559\u6388\u8868\u793a\uff1a”ENSURE\u7814\u7a76\u7684EOT\u6570\u636e\u975e\u5e38\u660e\u786e\u3002\u65e2\u5f80\u7814\u7a76\u663e\u793a\uff0csiRNA\u8054\u5408PEG-IFN\u03b1\u662f\u6700\u6709\u5e0c\u671b\u83b7\u5f97\u66f4\u9ad8HBsAg\u8840\u6e05\u6e05\u9664\u7684\u7597\u6cd5\u4e4b\u4e00\u3002ENSURE\u7814\u7a76\u9996\u6b21\u4e3asiRNA\u5728\u5df2\u6709\u7684PEG-IFN\u03b1\u7597\u6cd5\u57fa\u7840\u4e0a\u5bf9\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002\u6211\u4eec\u76f8\u4fe1\uff0celebsiran\u6709\u671b\u5bf9\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002”<\/p>\n

\u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a”\u8fd9\u9879\u8bd5\u9a8c\u6570\u636e\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\uff0c\u5b83\u5c06\u7ee7\u7eed\u652f\u6301\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7597\u6cd5\u7684\u76ee\u6807\u3002\u8be5\u7ed3\u679c\u51f8\u663e\u4e86elebsiran\u4f5c\u4e3a\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u8bc4\u4f30\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u6838\u5fc3\u7684\u6f5c\u529b\u3002\u6211\u4eec\u671f\u5f85\u7740\u901a\u8fc7\u6b63\u5728\u8fdb\u884c\u76842\u671f\u7814\u7a76\uff0c\u5c06elebsiran\u4e0e\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u4ee5\u4e3a\u5168\u74032.54\u4ebf\u6162\u6027HBV\u611f\u67d3\u8005\u63d0\u4f9b\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002”<\/p>\n

\u6458\u8981\u7f16\u53f7\uff1a5008
\u6700\u65b0\u7a81\u7834\u53e3\u5934\u62a5\u544a\u6807\u9898\uff1aElebsiran\uff08BRII-835\uff09\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5bf9\u6bd4 PEG-IFN\u03b1 \u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u521d\u6b65\u7ed3\u679c
\u8bb2\u8005\uff1a\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb<\/p>\n

\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0celebsiran 200 mg + PEG-IFN\u03b1\u961f\u5217\u548celebsiran 100 mg + PEG-IFN\u03b1\u961f\u5217\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u5206\u522b\u4e3a26.3%\uff085\/19\uff09\u548c33.3%\uff086\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u961f\u5217\uff085.6%\uff09\u3002\u5728HBsAg\u57fa\u7ebf\u4e3a100-1,500 IU\/mL\u7684\u4e9a\u7ec4\u4e2d\uff0c\u63a5\u53d7elebsiran 200 mg\u6216100 mg\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u540e\u5206\u522b\u670931.3%\uff085\/16\uff09\u621640.0%\uff086\/15\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002Elebsiran + PEG-IFN\u03b1\u961f\u5217\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u7684HBsAg\u4e0b\u964d\u5e45\u5ea6\uff08\u5e73\u5747\u503c[SE]\uff1aelebsiran 200 mg\u6216100 mg\u5206\u522b\u4e3a-2.47 [0.28]\u6216-3.01 [0.28] log10 IU\/mL\uff09\u5927\u4e8e PEG-IFN\u03b1\u961f\u5217\uff08-1.02 [0.30] log10 IU\/mL\uff09\u3002\u5728HBsAg\u57fa\u7ebf\u6c34\u5e73\u4e3a100-3,000 IU\/mL\u7684\u53c2\u4e0e\u8005\u4e2d\uff0c elebsiran 200 mg\u548c100 mg\u5242\u91cf\u8054\u5408PEG-IFN\u03b1\u53ef\u5b9e\u73b0\u76f8\u4f3c\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548cHBsAg\u964d\u5e45\u3002\u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6cbb\u7597\u540e\u968f\u8bbf\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u5c06\u5728\u6cbb\u7597\u7ed3\u675f\u540e\u7ee7\u7eed\u968f\u8bbf24\u5468\u3002<\/p>\n

\u4f5c\u4e3a\u817e\u76db\u535a\u836f\u5f00\u53d1HBV\u529f\u80fd\u6027\u6cbb\u6108\u72ec\u7279\u65b9\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u6211\u4eec\u5dee\u5f02\u5316\u4ea7\u54c1\u7ec4\u5408\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\uff0c\u5305\u62ecelebsiran\u3001\u9488\u5bf9HBV\u7684\u5728\u7814\u5e7f\u8c31\u4e2d\u548c\u6027\u5355\u514b\u9686\u6297\u4f53tobevibart\uff0c\u4ee5\u53ca\u91cd\u7ec4\u86cb\u767dHBV\u514d\u75ab\u6cbb\u7597\u836f\u7269BRII-179\u3002\u6211\u4eec\u5c06\u57282025\u5e74\u7684\u79d1\u5b66\u4f1a\u8bae\u4e0a\u5206\u4eab\u5173\u952e\u6570\u636e\u3002<\/p>\n

\u5173\u4e8e\u4e59\u578b\u809d\u708e<\/p>\n

\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u80c1\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.54\u4ebf\u3002[1]\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7ea6\u670982\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027HBV\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u3002[1]\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u4eba\u6570\u8fbe8,700\u4e07\uff0c\u975e\u5e38\u503c\u5f97\u5173\u6ce8\u3002[2]<\/p>\n

\u5173\u4e8eElebsiran\uff08BRII-835\uff0cVIR-2218\uff09<\/p>\n

Elebsiran\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u836f\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f6c\u5f55\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u4ea7\u751f\uff0c\u5176\u5177\u6709\u9488\u5bf9HBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u91c7\u7528\u589e\u5f3a\u7a33\u5b9a\u5316\u5b66\u589e\u5f3a\u6280\u672f\u7684siRNA\uff0c\u4ee5\u589e\u5f3a\u7a33\u5b9a\u6027\u5e76\u6700\u5927\u7a0b\u5ea6\u5730\u51cf\u5c11\u8131\u9776\u6d3b\u6027\uff0c\u4ece\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7597\u6307\u6570\u3002\u817e\u76db\u535a\u836f\u4e8e2020\u5e74\u4eceVir Biotechnology, Inc. \u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316elebsiran\u7684\u72ec\u5bb6\u6743\u76ca\u3002<\/p>\n

\u5173\u4e8e\u817e\u76db\u535a\u836f<\/p>\n

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[1] World Health Organization. (April 2024<\/span>). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/a>\u00a0<\/p>\n

[2] World Health Organization. Hepatitis. World Health Organization. Retrieved from https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/p>\n

SOURCE \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"

\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u63d0\u4f9b\u768448\u5468\u6cbb\u7597\u7ed3\u675f\u6570\u636e\u6e05\u695a\u5730\u8868\u660e\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u53ef\u5b9e\u73b0\u66f4\u591a\u83b7\u76ca\uff0c\u4ece\u800c\u83b7\u5f97\u66f4\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387 \u7531\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u5f00\u5c55\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\u6570\u636e\u5c06\u7ee7\u7eed\u652f\u6301\u516c\u53f8\u7684\u7b56\u7565\uff0c\u5373\u901a\u8fc7\u6b63\u786e\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u5b9e\u73b0HBV\u529f\u80fd\u6027\u6cbb\u6108 \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62024\u5e7411\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08”\u817e\u76db\u535a\u836f”\u6216”\u516c\u53f8”\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u533b\u7597\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u572811\u670815\u65e5\u81f319\u65e5\u4e8e\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u5730\u4e9a\u54e5\u4e3e\u884c\u7684\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a\uff08AASLD\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\uff08late-breaking\uff09\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\u3002 ENSURE\u662f\u4e00\u9879\u9633\u6027\u5bf9\u7167\u3001\u968f\u673a\u30012\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u8bd5\u9a8c\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09elebsiran\uff08BRII-835\uff0cVIR-2218\uff09\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5bf9\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u57fa\u7ebf\u4e3a100-3,000 IU\/mL\u7684\u6162\u6027HBV\u611f\u67d3\u8005\u7684\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u6392\u9664\u4e86HBsAg\u57fa\u7ebf\u6c34\u5e73\u8f83\u4f4e\uff08<100 IU\/mL\uff09\u7684HBV\u60a3\u8005\uff0c\u4ee5\u7814\u7a76\u5728\u66f4\u5e7f\u6cdb\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u6f5c\u5728\u7597\u6548\u3002ENSURE 48\u5468\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u6570\u636e\u663e\u793a\uff0c\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u63a5\u53d7200 mg\u6216100 mg elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u5206\u522b\u670926.3%\uff085\/19\uff09\u621633.3%\uff086\/18\uff09\u5b9e\u73b0HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u63a5\u53d7PEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u53ea\u67095.6%\uff081\/18\uff09\u5b9e\u73b0HBsAg\u8840\u6e05\u6e05\u9664\u3002 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb\u8d3e\u7ee7\u4e1c\u6559\u6388\u8868\u793a\uff1a”ENSURE\u7814\u7a76\u7684EOT\u6570\u636e\u975e\u5e38\u660e\u786e\u3002\u65e2\u5f80\u7814\u7a76\u663e\u793a\uff0csiRNA\u8054\u5408PEG-IFN\u03b1\u662f\u6700\u6709\u5e0c\u671b\u83b7\u5f97\u66f4\u9ad8HBsAg\u8840\u6e05\u6e05\u9664\u7684\u7597\u6cd5\u4e4b\u4e00\u3002ENSURE\u7814\u7a76\u9996\u6b21\u4e3asiRNA\u5728\u5df2\u6709\u7684PEG-IFN\u03b1\u7597\u6cd5\u57fa\u7840\u4e0a\u5bf9\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002\u6211\u4eec\u76f8\u4fe1\uff0celebsiran\u6709\u671b\u5bf9\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002” \u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a”\u8fd9\u9879\u8bd5\u9a8c\u6570\u636e\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\uff0c\u5b83\u5c06\u7ee7\u7eed\u652f\u6301\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7597\u6cd5\u7684\u76ee\u6807\u3002\u8be5\u7ed3\u679c\u51f8\u663e\u4e86elebsiran\u4f5c\u4e3a\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u8bc4\u4f30\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u6838\u5fc3\u7684\u6f5c\u529b\u3002\u6211\u4eec\u671f\u5f85\u7740\u901a\u8fc7\u6b63\u5728\u8fdb\u884c\u76842\u671f\u7814\u7a76\uff0c\u5c06elebsiran\u4e0e\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u4ee5\u4e3a\u5168\u74032.54\u4ebf\u6162\u6027HBV\u611f\u67d3\u8005\u63d0\u4f9b\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002” \u6458\u8981\u7f16\u53f7\uff1a5008\u6700\u65b0\u7a81\u7834\u53e3\u5934\u62a5\u544a\u6807\u9898\uff1aElebsiran\uff08BRII-835\uff09\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5bf9\u6bd4 PEG-IFN\u03b1 \u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u521d\u6b65\u7ed3\u679c\u8bb2\u8005\uff1a\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb \u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0celebsiran 200 mg + PEG-IFN\u03b1\u961f\u5217\u548celebsiran 100 mg + PEG-IFN\u03b1\u961f\u5217\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u5206\u522b\u4e3a26.3%\uff085\/19\uff09\u548c33.3%\uff086\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u961f\u5217\uff085.6%\uff09\u3002\u5728HBsAg\u57fa\u7ebf\u4e3a100-1,500 IU\/mL\u7684\u4e9a\u7ec4\u4e2d\uff0c\u63a5\u53d7elebsiran 200 mg\u6216100 mg\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u540e\u5206\u522b\u670931.3%\uff085\/16\uff09\u621640.0%\uff086\/15\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002Elebsiran + PEG-IFN\u03b1\u961f\u5217\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u7684HBsAg\u4e0b\u964d\u5e45\u5ea6\uff08\u5e73\u5747\u503c[SE]\uff1aelebsiran 200 mg\u6216100 mg\u5206\u522b\u4e3a-2.47 [0.28]\u6216-3.01 [0.28] log10 IU\/mL\uff09\u5927\u4e8e PEG-IFN\u03b1\u961f\u5217\uff08-1.02 [0.30] log10 IU\/mL\uff09\u3002\u5728HBsAg\u57fa\u7ebf\u6c34\u5e73\u4e3a100-3,000 IU\/mL\u7684\u53c2\u4e0e\u8005\u4e2d\uff0c elebsiran 200 mg\u548c100 mg\u5242\u91cf\u8054\u5408PEG-IFN\u03b1\u53ef\u5b9e\u73b0\u76f8\u4f3c\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548cHBsAg\u964d\u5e45\u3002\u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6cbb\u7597\u540e\u968f\u8bbf\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u5c06\u5728\u6cbb\u7597\u7ed3\u675f\u540e\u7ee7\u7eed\u968f\u8bbf24\u5468\u3002 \u4f5c\u4e3a\u817e\u76db\u535a\u836f\u5f00\u53d1HBV\u529f\u80fd\u6027\u6cbb\u6108\u72ec\u7279\u65b9\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u6211\u4eec\u5dee\u5f02\u5316\u4ea7\u54c1\u7ec4\u5408\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\uff0c\u5305\u62ecelebsiran\u3001\u9488\u5bf9HBV\u7684\u5728\u7814\u5e7f\u8c31\u4e2d\u548c\u6027\u5355\u514b\u9686\u6297\u4f53tobevibart\uff0c\u4ee5\u53ca\u91cd\u7ec4\u86cb\u767dHBV\u514d\u75ab\u6cbb\u7597\u836f\u7269BRII-179\u3002\u6211\u4eec\u5c06\u57282025\u5e74\u7684\u79d1\u5b66\u4f1a\u8bae\u4e0a\u5206\u4eab\u5173\u952e\u6570\u636e\u3002 \u5173\u4e8e\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u80c1\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.54\u4ebf\u3002[1]\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7ea6\u670982\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027HBV\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u3002[1]\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u4eba\u6570\u8fbe8,700\u4e07\uff0c\u975e\u5e38\u503c\u5f97\u5173\u6ce8\u3002[2] \u5173\u4e8eElebsiran\uff08BRII-835\uff0cVIR-2218\uff09 Elebsiran\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u836f\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV […]<\/p>\n","protected":false},"author":0,"featured_media":4521,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-4520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u817e\u76db\u535a\u836f\u9996\u6b21\u57282024\u5e74\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a (AASLD) \u5e74\u4f1a\u4e0a\u53d1\u5e03siRNA (Elebsiran) \u8054\u5408PEG-IFN\u03b1 \u5bf9\u6bd4PEG-IFN\u03b1 \u5355\u836f\u6cbb\u7597\u7684\u7ed3\u679c\uff0c\u8bc1\u660e\u8054\u5408siRNA\u53ef\u66f4\u663e\u8457\u63d0\u9ad8HBV\u8868\u9762\u6297\u539f\u6e05\u9664 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u817e\u76db\u535a\u836f\u9996\u6b21\u57282024\u5e74\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a-aasld-\u5e74\u4f1a\u4e0a\u53d1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u817e\u76db\u535a\u836f\u9996\u6b21\u57282024\u5e74\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a (AASLD) \u5e74\u4f1a\u4e0a\u53d1\u5e03siRNA (Elebsiran) \u8054\u5408PEG-IFN\u03b1 \u5bf9\u6bd4PEG-IFN\u03b1 \u5355\u836f\u6cbb\u7597\u7684\u7ed3\u679c\uff0c\u8bc1\u660e\u8054\u5408siRNA\u53ef\u66f4\u663e\u8457\u63d0\u9ad8HBV\u8868\u9762\u6297\u539f\u6e05\u9664 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u63d0\u4f9b\u768448\u5468\u6cbb\u7597\u7ed3\u675f\u6570\u636e\u6e05\u695a\u5730\u8868\u660e\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u53ef\u5b9e\u73b0\u66f4\u591a\u83b7\u76ca\uff0c\u4ece\u800c\u83b7\u5f97\u66f4\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387 \u7531\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u5f00\u5c55\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\u6570\u636e\u5c06\u7ee7\u7eed\u652f\u6301\u516c\u53f8\u7684\u7b56\u7565\uff0c\u5373\u901a\u8fc7\u6b63\u786e\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u5b9e\u73b0HBV\u529f\u80fd\u6027\u6cbb\u6108 \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62024\u5e7411\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08”\u817e\u76db\u535a\u836f”\u6216”\u516c\u53f8”\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u533b\u7597\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u572811\u670815\u65e5\u81f319\u65e5\u4e8e\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u5730\u4e9a\u54e5\u4e3e\u884c\u7684\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u5b66\u4f1a\uff08AASLD\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\uff08late-breaking\uff09\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\u3002 ENSURE\u662f\u4e00\u9879\u9633\u6027\u5bf9\u7167\u3001\u968f\u673a\u30012\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u8bd5\u9a8c\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09elebsiran\uff08BRII-835\uff0cVIR-2218\uff09\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5bf9\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u57fa\u7ebf\u4e3a100-3,000 IU\/mL\u7684\u6162\u6027HBV\u611f\u67d3\u8005\u7684\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u6392\u9664\u4e86HBsAg\u57fa\u7ebf\u6c34\u5e73\u8f83\u4f4e\uff08<100 IU\/mL\uff09\u7684HBV\u60a3\u8005\uff0c\u4ee5\u7814\u7a76\u5728\u66f4\u5e7f\u6cdb\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u6f5c\u5728\u7597\u6548\u3002ENSURE 48\u5468\u6cbb\u7597\u7ed3\u675f\uff08EOT\uff09\u6570\u636e\u663e\u793a\uff0c\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u63a5\u53d7200 mg\u6216100 mg elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u5206\u522b\u670926.3%\uff085\/19\uff09\u621633.3%\uff086\/18\uff09\u5b9e\u73b0HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u63a5\u53d7PEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e2d\u53ea\u67095.6%\uff081\/18\uff09\u5b9e\u73b0HBsAg\u8840\u6e05\u6e05\u9664\u3002 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb\u8d3e\u7ee7\u4e1c\u6559\u6388\u8868\u793a\uff1a”ENSURE\u7814\u7a76\u7684EOT\u6570\u636e\u975e\u5e38\u660e\u786e\u3002\u65e2\u5f80\u7814\u7a76\u663e\u793a\uff0csiRNA\u8054\u5408PEG-IFN\u03b1\u662f\u6700\u6709\u5e0c\u671b\u83b7\u5f97\u66f4\u9ad8HBsAg\u8840\u6e05\u6e05\u9664\u7684\u7597\u6cd5\u4e4b\u4e00\u3002ENSURE\u7814\u7a76\u9996\u6b21\u4e3asiRNA\u5728\u5df2\u6709\u7684PEG-IFN\u03b1\u7597\u6cd5\u57fa\u7840\u4e0a\u5bf9\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002\u6211\u4eec\u76f8\u4fe1\uff0celebsiran\u6709\u671b\u5bf9\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002” \u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a”\u8fd9\u9879\u8bd5\u9a8c\u6570\u636e\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\uff0c\u5b83\u5c06\u7ee7\u7eed\u652f\u6301\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7597\u6cd5\u7684\u76ee\u6807\u3002\u8be5\u7ed3\u679c\u51f8\u663e\u4e86elebsiran\u4f5c\u4e3a\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u8bc4\u4f30\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u6838\u5fc3\u7684\u6f5c\u529b\u3002\u6211\u4eec\u671f\u5f85\u7740\u901a\u8fc7\u6b63\u5728\u8fdb\u884c\u76842\u671f\u7814\u7a76\uff0c\u5c06elebsiran\u4e0e\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u4ee5\u4e3a\u5168\u74032.54\u4ebf\u6162\u6027HBV\u611f\u67d3\u8005\u63d0\u4f9b\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002” \u6458\u8981\u7f16\u53f7\uff1a5008\u6700\u65b0\u7a81\u7834\u53e3\u5934\u62a5\u544a\u6807\u9898\uff1aElebsiran\uff08BRII-835\uff09\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5bf9\u6bd4 PEG-IFN\u03b1 \u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u521d\u6b65\u7ed3\u679c\u8bb2\u8005\uff1a\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb \u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0celebsiran 200 mg + PEG-IFN\u03b1\u961f\u5217\u548celebsiran 100 mg + PEG-IFN\u03b1\u961f\u5217\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u5206\u522b\u4e3a26.3%\uff085\/19\uff09\u548c33.3%\uff086\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u961f\u5217\uff085.6%\uff09\u3002\u5728HBsAg\u57fa\u7ebf\u4e3a100-1,500 IU\/mL\u7684\u4e9a\u7ec4\u4e2d\uff0c\u63a5\u53d7elebsiran 200 mg\u6216100 mg\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u540e\u5206\u522b\u670931.3%\uff085\/16\uff09\u621640.0%\uff086\/15\uff09\u7684\u53c2\u4e0e\u8005\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002Elebsiran + PEG-IFN\u03b1\u961f\u5217\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u7684HBsAg\u4e0b\u964d\u5e45\u5ea6\uff08\u5e73\u5747\u503c[SE]\uff1aelebsiran 200 mg\u6216100 mg\u5206\u522b\u4e3a-2.47 [0.28]\u6216-3.01 [0.28] log10 IU\/mL\uff09\u5927\u4e8e PEG-IFN\u03b1\u961f\u5217\uff08-1.02 [0.30] log10 IU\/mL\uff09\u3002\u5728HBsAg\u57fa\u7ebf\u6c34\u5e73\u4e3a100-3,000 IU\/mL\u7684\u53c2\u4e0e\u8005\u4e2d\uff0c elebsiran 200 mg\u548c100 mg\u5242\u91cf\u8054\u5408PEG-IFN\u03b1\u53ef\u5b9e\u73b0\u76f8\u4f3c\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548cHBsAg\u964d\u5e45\u3002\u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6cbb\u7597\u540e\u968f\u8bbf\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u5c06\u5728\u6cbb\u7597\u7ed3\u675f\u540e\u7ee7\u7eed\u968f\u8bbf24\u5468\u3002 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