{"id":4944,"date":"2024-11-28T13:13:00","date_gmt":"2024-11-28T13:13:00","guid":{"rendered":"http:\/\/moneycompass.com.my\/cn\/%e7%be%8e%e7%ba%b3%e9%87%8c%e5%b0%bc%e9%9b%86%e5%9b%a2%e5%9c%a8%e4%b9%b3%e8%85%ba%e7%99%8c%e7%a0%94%e8%ae%a8%e4%bc%9a%e5%b1%95%e7%a4%ba%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae%e5%b7%a9%e5%9b%baorserdu\/"},"modified":"2024-11-28T13:13:00","modified_gmt":"2024-11-28T13:13:00","slug":"%e7%be%8e%e7%ba%b3%e9%87%8c%e5%b0%bc%e9%9b%86%e5%9b%a2%e5%9c%a8%e4%b9%b3%e8%85%ba%e7%99%8c%e7%a0%94%e8%ae%a8%e4%bc%9a%e5%b1%95%e7%a4%ba%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae%e5%b7%a9%e5%9b%baorserdu","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e7%be%8e%e7%ba%b3%e9%87%8c%e5%b0%bc%e9%9b%86%e5%9b%a2%e5%9c%a8%e4%b9%b3%e8%85%ba%e7%99%8c%e7%a0%94%e8%ae%a8%e4%bc%9a%e5%b1%95%e7%a4%ba%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae%e5%b7%a9%e5%9b%baorserdu\/","title":{"rendered":"\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u5728\u4e73\u817a\u764c\u7814\u8ba8\u4f1a\u5c55\u793a\u6700\u65b0\u6570\u636e\u5de9\u56faORSERDU\u00ae (Elacestrant)\u7684\u4f5c\u7528"},"content":{"rendered":"

\u771f\u5b9e\u8bc1\u636e\u652f\u6491ORSERDU\u5bf9\u4e8eER+\/HER2- ESR1\u7a81\u53d8\u665a\u671f\u6216mBC\u60a3\u8005\u7684\u7597\u6548\u3002\u65e0\u8bbaESR1\u7a81\u53d8\u72b6\u6001\u5982\u4f55\uff0celacestrant\u4e0eabemaciclib\u8054\u5408\u6cbb\u7597\u7684\u6700\u65b0\u7ed3\u679c\u5c55\u73b0\u51fa\u663e\u8457\u7684\u7597\u6548\uff0c\u5e76\u5728ER+\/HER2- mBC\u60a3\u8005\u4e2d\u5448\u73b0\u53ef\u63a7\u4e14\u53ef\u9884\u6d4b\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u7ebd\u7ea6<\/span>2024\u5e7411\u670828\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u9886\u5148\u7684\u8de8\u56fd\u5236\u836f\u53ca\u8bca\u65ad\u516c\u53f8\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2(“Menarini”)\uff0c\u4ee5\u53ca\u5176\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u5f00\u53d1\u764c\u75c7\u8f6c\u5316\u7597\u6cd5\u7684\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc. (“Stemline”)\uff0c\u5c06\u57282024\u5e7412\u670810\u65e5\u81f313\u65e5\u4e3e\u529e\u7684\u5723\u5b89\u4e1c\u5c3c\u5965\u4e73\u817a\u764c\u7814\u8ba8\u4f1a(SABCS)\u4e0a\u5c55\u793a\u6709\u5173ORSERDU\u00ae (elacestrant)\u7684\u6700\u65b0\u6269\u5c55\u7814\u7a76\u6570\u636e\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u516c\u53f8\u5c06\u53d1\u5e03ORSERDU\u7528\u4e8eER+\/HER2-\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u6210\u5e74\u60a3\u8005\u7684\u771f\u5b9e\u4e16\u754c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(rwPFS)\u7ed3\u679c\u3002 \u6b64\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u5c06\u5c55\u793aelacestrant\u4e0eabemaciclib\u8054\u5408\u6cbb\u7597\u7684\u6700\u65b0\u7597\u6548\u6570\u636e\uff0c\u4ee5\u53ca\u6765\u81eaELECTRA\u548cELEVATE\u4e24\u9879\u8bd5\u9a8c1b\/2\u671f\u7684\u6c47\u603b\u5b89\u5168\u6027\u5206\u6790\u7ed3\u679c\u3002<\/p>\n

<\/div>\n

ORSERDU\u771f\u5b9e\u4e16\u754c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6570\u636e <\/p>\n

ORSERDU\u662f\u7b2c\u4e00\u79cd\u4e14\u552f\u4e00\u4e00\u79cd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597ESR1\u7a81\u53d8\u80bf\u7624\u7684\u53e3\u670d\u96cc\u6fc0\u7d20\u53d7\u4f53\u62ee\u6297\u5242(SERD)\u3002\u8fd9\u7c7b\u7a81\u53d8\u80bf\u7624\u5728ER+\u3001HER2- \u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u4e2d\u7684\u53d1\u751f\u7387\u9ad8\u8fbe50%\uff0c\u539f\u56e0\u662f\u60a3\u8005\u5148\u524d\u5728\u764c\u75c7\u8f6c\u79fb\u7684\u60c5\u51b5\u4e0b\u63a5\u53d7\u8fc7\u5185\u5206\u6ccc\u6cbb\u7597(ET)\u3002 \u81ea2023\u5e741\u6708\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u6279\u51c6\u4ee5\u6765\uff0cORSERDU\u5df2\u79ef\u7d2f\u5145\u5206\u7684\u65f6\u95f4\uff0c\u5f97\u4ee5\u63cf\u8ff0\u5728\u5f53\u524d\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u6cbb\u7597\u9886\u57df\u4e2d\u7684\u771f\u5b9e\u4e16\u754c\u5e94\u7528\u60c5\u51b5\u3002<\/p>\n

\u5373\u5c06\u5728SABCS 2024\u4e0a\u53d1\u5e03\u7684\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cORSERDU\u5bf9ER+\/HER2- \u665a\u671f\u6216mBC\u60a3\u8005\u7684\u771f\u5b9e\u4e16\u754c\u5e94\u7528\u8868\u73b0\u51fa\u7597\u6548\u3002 \u603b\u4f53\u4eba\u7fa4\u5206\u6790\u663e\u793a\u4e2d\u4f4drwPFS\u4e3a6.8\u4e2a\u6708\u3002 \u65e2\u5f80\u63a5\u53d7\u8fc71-2\u7ebfET\u6cbb\u7597\u7684mBC\u60a3\u8005\u7684\u4e2d\u4f4drwPFS\u4e3a8\u4e2a\u6708\u3002 \u5206\u6790\u4e2d\u5728\u5404\u4e9a\u7ec4\u89c2\u5bdf\u5230\u7684rwPFS\u8868\u73b0\u51fa\u4e00\u81f4\u6027\u3002 \u5176\u4ed6\u60a3\u8005\u4e9a\u7ec4\u7684\u6700\u65b0\u7ed3\u679c\u548c\u5176\u4ed6\u4fe1\u606f\u4e5f\u5c06\u5728\u5927\u4f1a\u4e0a\u5c55\u793a\u3002<\/p>\n

\u5b8c\u6574\u6458\u8981(SESS-1876)\u53ef\u5728\u6b64\u5904<\/a>\u67e5\u770b\uff08\u7b2c1748\u9875\uff09\u3002<\/p>\n

\u201c\u8fd9\u4e9b\u6fc0\u52a8\u4eba\u5fc3\u7684\u6570\u636e\u663e\u793a\uff0cORSERDU\u5355\u836f\u6cbb\u7597\u53ef\u5b9e\u73b0\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u771f\u5b9e\u4e16\u754c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u201dUT Health San Antonio MD Anderson Cancer Center\u4e73\u817a\u80bf\u7624\u5b66\u5bb6\u517c\u533b\u5b66\u6559\u6388\u3001\u533b\u5b66\u535a\u58ebVirginia Kaklamani\u8868\u793a\uff0c \u201c\u4f5c\u4e3a\u6267\u4e1a\u533b\u5e08\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u6709\u5fc5\u8981\u4f7f\u7528\u6db2\u4f53\u6d3b\u68c0\u5728\u6bcf\u6b21\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u65f6\u68c0\u6d4b\u60a3\u8005\u80bf\u7624\u662f\u5426\u5b58\u5728ESR1\u7a81\u53d8\uff0c\u4ee5\u4fbf\u6211\u4eec\u80fd\u6070\u5f53\u5730\u4e3a\u60a3\u8005\u5b9a\u5236\u6cbb\u7597\u624b\u6bb5\uff0c\u5e76\u4f18\u5316\u5bf9\u5176\u7684\u62a4\u7406\u3002\u201d<\/p>\n

elacestrant\u4e0eabemaciclib\u8054\u5408\u7528\u836f\u7814\u7a76 <\/p>\n

ELEVATE\u548cELECTRA\u8fd9\u4e24\u98791b\/2\u671f\u7814\u7a76\u7684\u8bbe\u8ba1\u76ee\u6807\u662f\u901a\u8fc7\u8054\u5408\u6cbb\u7597\u7b56\u7565\u6765\u8bc4\u4f30\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\uff0c\u8fd9\u4e9b\u7b56\u7565\u65e8\u5728\u514b\u670d\u80bf\u7624\u5bf9\u5185\u5206\u6ccc\u6cbb\u7597(ET)\u7684\u8010\u836f\u6027\u3002 \u00a0<\/p>\n

\u5373\u5c06\u5728SABCS 2024\u53d1\u5e03\u7684\u7814\u7a76\u7ed3\u679c\u5c06\u6db5\u76d6ELECTRA\u7814\u7a76\u7684\u6700\u65b0\u7597\u6548\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u5c55\u73b0\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u7684\u79ef\u6781\u8868\u73b0\u3002 \u5728\u6240\u6709\u80fd\u8bc4\u4f30\u7597\u6548\u7684\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(mPFS)\u4e3a8.6\u4e2a\u6708\u3002 \u5728\u53d1\u73b0ESR1\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\uff0cmPFS\u4e3a8.7\u4e2a\u6708\u3002 \u6ca1\u6709ESR1\u7a81\u53d8\u7684\u60a3\u8005\u7684mPFS\u4e3a7.2\u4e2a\u6708\u3002<\/p>\n

\u6b64\u5916\uff0c\u5bf9ELECTRA\u548cELEVATE\u4e24\u9879\u7814\u7a76\u7684\u60a3\u8005\u8fdb\u884c\u7684\u6c47\u603b\u5b89\u5168\u6027\u5206\u6790\u8868\u660e\uff0c\u5bf9\u4e8e\u5148\u524d\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u7ebf\u6cbb\u7597\u7684ER+\/HER2- mBC\u60a3\u8005\uff0c\u4f7f\u7528elacestrant\u4e0eabemaciclib\u8054\u5408\u6cbb\u7597\u8868\u73b0\u51fa\u53ef\u63a7\u4e14\u53ef\u9884\u6d4b\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002 \u6240\u6709\u63a5\u53d7\u8be5\u8054\u5408\u7528\u836f\u7684\u60a3\u8005\u90fd\u8fdb\u884c\u8fc7\u5b89\u5168\u6027\u8bc4\u4f30\uff0c\u7ed3\u679c\u4e0e\u4e24\u79cd\u5316\u5408\u7269\u7684\u5df2\u77e5\u5b89\u5168\u6027\u4e00\u81f4\u3002 \u6240\u6709\u7ea7\u522b\u4e2d\u6700\u5e38\u89c1(\u226520%)\u7684\u4e0d\u826f\u53cd\u5e94(AE)\u5305\u62ec\u8179\u6cfb\u3001\u6076\u5fc3\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5455\u5410\u3001\u75b2\u52b3\u3001\u8d2b\u8840\u4ee5\u53ca\u98df\u6b32\u51cf\u9000\u3002 \u672a\u89c2\u5bdf\u52304\u7ea7\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n

\u5b8c\u6574\u6458\u8981(SESS-1910)\u53ef\u5728\u6b64\u5904<\/a>\u67e5\u770b\uff08\u7b2c3330\u9875\uff09\u3002<\/p>\n

\u201celacestrant\u4e0eabemaciclib\u8054\u5408\u7528\u836f\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\u6301\u7eed\u5448\u73b0\u79ef\u6781\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6570\u636e\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u800c\u4e14\u8fd9\u4e24\u79cd\u836f\u7269\u5728\u7528\u4e8e\u8054\u5408\u6cbb\u7597\u65f6\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u6bd2\u6027\u53cd\u5e94\uff0c\u201d\u533b\u5b66\u535a\u58eb\u3001\u533b\u5b66\u6559\u6388\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u4e73\u817a\u764c\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u6559\u80b2\u673a\u6784\u4e3b\u4efb\u517c\u4e73\u817a\u764c\u6559\u6388Hope S. Rugo\u8868\u793a\uff0c \u201celacestrant\u7ee7\u7eed\u5c55\u73b0\u51fa\u6709\u6f5c\u529b\u6210\u4e3a\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u8054\u5408\u65b9\u6848\u7684\u5185\u5206\u6ccc\u6cbb\u7597\u4e3b\u8981\u624b\u6bb5\uff0c\u968f\u7740\u8fd9\u4e9b\u8bd5\u9a8c\u53d6\u5f97\u8fdb\u5c55\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u6df1\u5165\u63a2\u7d22\u8fd9\u79cd\u6cbb\u7597\u7ec4\u5408\u3002\u201d<\/p>\n

\u201c\u89c1\u8bc1\u5728\u771f\u5b9e\u4e16\u754c\u73af\u5883\u4e2d\u53d6\u5f97\u8fd9\u6837\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6210\u679c\u4ee4\u4eba\u632f\u594b\uff0c\u8fd9\u8868\u660eORSERDU\u4f7f\u80bf\u7624\u79d1\u533b\u751f\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u5b9e\u8d28\u6027\u7684\u7597\u6548\uff0c\u201d\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u9996\u5e2d\u6267\u884c\u5b98Elcin Barker Ergun\u8868\u793a\uff0c \u201c\u6211\u4eec\u81f4\u529b\u4e8e\u63a8\u52a8\u6709\u5173elacestrant\u7684\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\uff0c\u5e76\u5728\u5355\u836f\u6cbb\u7597\u548c\u8054\u5408\u6cbb\u7597\u73af\u5883\u4e2d\u4f7f\u5176\u53d1\u6325\u5168\u90e8\u6f5c\u529b\uff0c\u76ee\u6807\u662f\u5c06ORSERDU\u5e26\u7ed9\u53ef\u80fd\u53d7\u76ca\u7684\u65b0\u60a3\u8005\u7fa4\u4f53\u3002\u201d<\/p>\n

Menarini Stemline\u8fd8\u5c06\u5206\u4eab3\u671fEMERALD\u8bd5\u9a8c\u7684\u5176\u4ed6\u76f8\u5173\u6570\u636e\uff0c\u4ee5\u53ca\u82e5\u5e72\u9879\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002<\/p>\n

Menarini Stemline\u6458\u8981\u5b8c\u6574\u5217\u8868\uff1a <\/p>\n

\u6807\u9898\uff1aelacestrant\u7528\u4e8eER+\/HER2- \u665a\u671f\u4e73\u817a\u764c\u6210\u5e74\u60a3\u8005\u7684\u771f\u5b9e\u4e16\u754c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(rwPFS)\u7ed3\u679c\uff1a\u4f7f\u7528\u7f8e\u56fd\u4fdd\u9669\u7d22\u8d54\u6570\u636e\u5f00\u5c55\u7684\u56de\u987e\u6027\u5206\u6790
\u6d77\u62a5\u7f16\u53f7\uff1aP3-10-08
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670812\u65e5\u661f\u671f\u56db\u4e0b\u534812\u65f6\u81f32\u65f6
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aElyse Swallow<\/span><\/p>\n

\u6807\u9898\uff1aelacestrant\u4e0eabemaciclib (abema)\u8054\u5408\u6cbb\u7597\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027(ER+)\u3001HER2\u9634\u6027(HER2-)\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u60a3\u8005(pts)
\u6d77\u62a5\u7f16\u53f7\uff1aPS7-07
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670812\u65e5\u661f\u671f\u56db\u4e0a\u53487\u65f6\u81f38\u65f630\u5206
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aHope Rugo<\/span><\/p>\n

\u6807\u9898\uff1a\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027(ER+)\u3001HER2\u9634\u6027(HER2-)\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u60a3\u8005\u7684elacestrant\u8054\u5408\u7528\u836f\uff1a\u6765\u81ea1b\/2\u671f\u3001\u5f00\u653e\u6807\u7b7e\u3001\u4f1e\u5f0f\u7814\u7a76ELEVATE\u60c5\u51b5\u66f4\u65b0
\u6d77\u62a5\u7f16\u53f7\uff1aPS7-06
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670812\u65e5\u661f\u671f\u56db\u4e0a\u53487\u65f6\u81f38\u65f630\u5206
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aHope Rugo<\/span><\/p>\n

\u6807\u9898\uff1aelacestrant\u4e0e\u6807\u51c6\u6cbb\u7597(SOC)\u5bf9ER+\u3001HER2- \u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u4f34ESR1\u7a81\u53d8\u80bf\u7624\u7684\u6bd4\u8f83\uff1a\u6765\u81ea3\u671fEMERALD\u8bd5\u9a8c\u7684ESR1\u7b49\u4f4d\u57fa\u56e0\u9891\u7387\u548c\u4e34\u5e8a\u6d3b\u6027
\u6d77\u62a5\u7f16\u53f7\uff1aP1-01-25
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670811\u65e5\u661f\u671f\u4e09\u4e0b\u534812\u65f6\u81f32\u65f6
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aAditya Bardia<\/p>\n

\u6807\u9898\uff1aELEGANT\uff1a\u7ed3\u8282\u9633\u6027\u3001\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2\u9634\u6027\u3001\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u65e9\u671f\u4e73\u817a\u764c\u5973\u6027\u548c\u7537\u6027\u60a3\u8005\u63a5\u53d7elacestrant\u5bf9\u6bd4\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e3\u671f\u7814\u7a76
\u6d77\u62a5\u7f16\u53f7\uff1aP2-08-21
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670811\u65e5\u661f\u671f\u4e09\u4e0b\u53485\u65f630\u5206\u81f37\u65f630\u5206
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aAditya Bardia<\/p>\n

\u6807\u9898\uff1a ADELA\uff1a\u4e00\u9879\u968f\u673a\u30013\u671f\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u9762\u5411\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597(ET)\u4ee5\u53caCDK4\/6i\u540e\u51fa\u73b0ESR1\u7a81\u53d8\u80bf\u7624\u8fdb\u5c55\u7684ER+\/HER2- \u665a\u671f\u4e73\u817a\u764c(aBC)\u60a3\u8005
\u6d77\u62a5\u7f16\u53f7\uff1aP2-10-21
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670811\u65e5\u661f\u671f\u4e09\u4e0b\u53485\u65f630\u5206\u81f37\u65f630\u5206
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aAntonio Llombart-Cussac<\/span><\/p>\n

\u6807\u9898\uff1a ELCIN\uff1a\u5bf9\u4ece\u672a\u91c7\u7528CDK4\/6\u6291\u5236\u5242(CDK4\/6i)\u6cbb\u7597\u7684\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027(ER+)\u3001HER2\u9634\u6027(HER2-)\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u60a3\u8005\u5f00\u5c55\u7684Elacestrant\u6cbb\u7597\uff1a\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc32\u671f\u7814\u7a76
\u6d77\u62a5\u7f16\u53f7\uff1aP2-08-20
\u65e5\u671f\u548c\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670811\u65e5\u661f\u671f\u4e09\u4e0b\u53485\u65f630\u5206\u81f37\u65f630\u5206
\u5730\u70b9\uff1a\u5f85\u5b9a
\u62a5\u544a\u4f5c\u8005\uff1aVirginia Kaklamani<\/p>\n

###<\/p>\n

\u5173\u4e8eelacestrant\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee<\/p>\n

\u591a\u9879\u7531\u4f01\u4e1a\u8d44\u52a9\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5728\u5355\u72ec\u6216\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u5bf9elacestrant\u8fdb\u884c\u7814\u7a76\u3002 EMERALD (NCT03778931<\/a>)\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u6d3b\u6027\u5bf9\u71673\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4f5c\u4e3a\u4e8c\u7ebf\u6216\u4e09\u7ebf\u5355\u836f\u7528\u4e8eER+\u3001HER2- \u665a\u671f\/\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002 ELEVATE (NCT05563220<\/a>)\u662f\u4e00\u98791b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4e0e\u963f\u57f9\u5229\u53f8\u3001\u4f9d\u7ef4\u83ab\u53f8\u3001\u5361\u5339\u8428\u66ff\u5c3c\u3001\u5e15\u535a\u897f\u5c3c\u3001\u745e\u535a\u897f\u5229\u6216abemaciclib\u8054\u5408\u7528\u836f\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002 ELECTRA (NCT05386108<\/a>)\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc31b\/2\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4e0eabemaciclib\u8054\u5408\u7528\u4e8eER+\u3001HER2- \u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002 2\u671f\u90e8\u5206\u9488\u5bf9\u8111\u8f6c\u79fb\u60a3\u8005\u8bc4\u4f30\u8be5\u6cbb\u7597\u65b9\u6848\u3002 ELCIN (NCT05596409<\/a>)\u662f\u4e00\u98792\u671f\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u6216\u4e24\u79cd\u6fc0\u7d20\u6cbb\u7597\u4e14\u5728\u764c\u75c7\u8f6c\u79fb\u60c5\u51b5\u4e0b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7CDK4\/6\u6291\u5236\u5242\u6cbb\u7597\u7684ER+\u3001HER2- \u665a\u671f\/\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u7597\u6548\u3002 ADELA (NCT06382948<\/a>)\u662f\u4e00\u98793\u671f\u3001\u968f\u673a\u3001\u53cc\u76f2\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8eER+\u3001HER2- mBC\u4f34ESR1\u7a81\u53d8\u80bf\u7624\u60a3\u8005\u7684\u7597\u6548\u3002 ELEGANT (NCT06492616<\/a>)\u662f\u4e00\u98793\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30elacestrant\u5bf9\u6bd4\u6807\u51c6\u5185\u5206\u6ccc\u7528\u4e8e\u6cbb\u7597\u7ed3\u8282\u9633\u6027\u3001\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2\u9634\u6027\u3001\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u65e9\u671f\u4e73\u817a\u764c\u5973\u6027\u548c\u7537\u6027\u60a3\u8005\u3002 \u7531\u7814\u7a76\u8005\u4e3b\u5bfc\u7684\u5176\u4ed6\u8bd5\u9a8c\u3001\u4e0e\u5176\u4ed6\u516c\u53f8\u5408\u4f5c\u5f00\u5c55\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u548c\u65e9\u671f\u75be\u75c5\u8bd5\u9a8c\u4e2d\u4e5f\u5728\u5bf9Elacestrant\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n

\u5173\u4e8eORSERDU (elacestrant)<\/p>\n

\u7f8e\u56fd\u9002\u5e94\u75c7\uff1aORSERDU (elacestrant)\uff0c345 mg\u7247\u5242\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u60a3\u96cc\u6fc0\u7d20\u53d7\u4f53(ER)\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532 (HER2)\u9634\u6027\u3001ESR1\u7a81\u53d8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u7684\u7edd\u7ecf\u540e\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002<\/p>\n

\u6709\u5173\u7f8e\u56fd\u7684\u5b8c\u6574\u5904\u65b9\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.orserdu.com<\/a>\u3002<\/p>\n

\u91cd\u8981\u5b89\u5168\u6027\u4fe1\u606f<\/p>\n

\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879<\/p>\n

\u8840\u8102\u5f02\u5e38\uff1a\u670d\u7528ORSERDU\u7684\u60a3\u8005\u4e2d\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a30%\u548c27%\u3002 3\u7ea7\u548c4\u7ea7\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a0.9%\u548c2.2%\u3002\u00a0\u00a0 \u5728\u5f00\u59cb\u670d\u7528ORSERDU\u4e4b\u524d\u53ca\u670d\u7528\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u8102\u3002<\/p>\n

\u80da\u80ce\u6bd2\u6027\uff1a\u6839\u636e\u52a8\u7269\u8bd5\u9a8c\u7ed3\u679c\u53ca\u5176\u4f5c\u7528\u673a\u5236\uff0c\u5bf9\u5b55\u5987\u4f7f\u7528ORSERDU\u53ef\u80fd\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\u3002 \u5411\u5b55\u5987\u548c\u80b2\u9f84\u5973\u6027\u544a\u77e5\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u3002 \u5efa\u8bae\u80b2\u9f84\u5973\u6027\u5728\u4f7f\u7528ORSERDU\u8fdb\u884c\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002 \u5efa\u8bae\u6709\u80b2\u9f84\u5973\u6027\u4f34\u4fa3\u7684\u7537\u6027\u60a3\u8005\u5728\u4f7f\u7528ORSERDU\u8fdb\u884c\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<\/p>\n

\u4e0d\u826f\u53cd\u5e94<\/p>\n

\u63a5\u53d7ORSERDU\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670912%\u51fa\u73b0\u8fc7\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002 \u8d85\u8fc71%\u7684\u63a5\u53d7ORSERDU\u6cbb\u7597\u60a3\u8005\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u808c\u8089\u9aa8\u9abc\u75bc\u75db(1.7%)\u548c\u6076\u5fc3(1.3%)\u3002 \u63a5\u53d7ORSERDU\u6cbb\u7597\u60a3\u8005\u4e2d\u67091.7%\u51fa\u73b0\u8fc7\u81f4\u547d\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u5fc3\u810f\u9aa4\u505c\u3001\u611f\u67d3\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u672a\u77e5\u539f\u56e0\uff08\u54041\u540d\u60a3\u8005\uff09\u3002\u5305\u62ec\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u6307\u6807\u5f02\u5e38\u5728\u5185\uff0cORSERDU\u5f15\u53d1\u7684
\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94(\u226510%)\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db(41%)\u3001\u6076\u5fc3(35%)\u3001\u80c6\u56fa\u9187\u5347\u9ad8(30%)\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8(29%)\u3001\u7518\u6cb9\u4e09\u916f\u5347\u9ad8(27%)\u3001\u75b2\u52b3(26%)\u3001\u8840\u7ea2\u86cb\u767d\u51cf\u5c11(26%)\u3001\u5455\u5410(19%)\u3001\u8c37\u4e19\u8f6c\u6c28\u9176\u5347\u9ad8(17%)\u3001\u94a0\u51cf\u5c11(16%)\u3001\u808c\u9178\u9150\u5347\u9ad8(16%)\u3001\u98df\u6b32\u51cf\u9000(15%)\u3001\u8179\u6cfb(13%)\u3001\u5934\u75db(12%)\u3001\u4fbf\u79d8(12%)\u3001\u8179\u75db(11%)\u3001\u6f6e\u70ed(11%)\u548c\u6d88\u5316\u4e0d\u826f(10%)\u3002<\/p>\n

\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/p>\n

\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u548c\/\u6216\u6291\u5236\u5242\u540c\u65f6\u4f7f\u7528\uff1a\u907f\u514d\u5f3a\u6216\u4e2dCYP3A4\u6291\u5236\u5242\u4e0eORSERDU\u540c\u65f6\u4f7f\u7528\u3002 \u907f\u514d\u5f3a\u6216\u4e2dCYP3A4\u8bf1\u5bfc\u5242\u4e0eORSERDU\u540c\u65f6\u4f7f\u7528\u3002<\/p>\n

\u7279\u6b8a\u4eba\u7fa4\u7528\u836f<\/p>\n

\u54fa\u4e73\uff1a\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7ORSERDU\u6cbb\u7597\u671f\u95f4\u548c\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u4e0d\u8fdb\u884c\u6bcd\u4e73\u5582\u517b\u3002<\/p>\n

\u809d\u529f\u80fd\u635f\u5bb3\uff1a\u907f\u514d\u5bf9\u4e25\u91cd\u809d\u529f\u80fd\u635f\u5bb3(Child-Pugh C)\u60a3\u8005\u4f7f\u7528ORSERDU\u3002 \u5bf9\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3(Child-Pugh B)\u60a3\u8005\u51cf\u5c11ORSERDU\u5242\u91cf\u3002<\/p>\n

ORSERDU\u5bf9\u513f\u79d1\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u4e0d\u786e\u5b9a\u3002<\/p>\n

\u5982\u9700\u62a5\u544a\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\uff0c\u8bf7\u81f4\u75351-877-332-7961\u8054\u7cfbStemline Therapeutics, Inc.\uff0c\u6216\u901a\u8fc71-800-FDA-1088\u6216www.fda.gov\/medwatch<\/a>\u8054\u7cfbFDA\u3002<\/p>\n

\u5173\u4e8e\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2<\/p>\n

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\u5173\u4e8eStemline Therapeutics Inc.<\/p>\n

Stemline Therapeutics, Inc. (“Stemline”)\u662f\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u65d7\u4e0b\u7684\u4e00\u5bb6\u5168\u8d44\u5b50\u516c\u53f8\uff0c\u4f5c\u4e3a\u5546\u4e1a\u5316\u9636\u6bb5\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u65b0\u578b\u764c\u75c7\u7597\u6cd5\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002 Stemline\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5b9e\u73b0ORSERDU\u00ae (elacestrant)\u7684\u5546\u4e1a\u5316\uff0c\u8fd9\u79cd\u53e3\u670d\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269\u9002\u7528\u4e8e\u6cbb\u7597\u60a3\u96cc\u6fc0\u7d20\u53d7\u4f53(ER)\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532 (HER2)\u9634\u6027\u3001ESR1\u7a81\u53d8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u4e14\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u5185\u5206\u6ccc\u7597\u6cd5\u540e\u75be\u75c5\u53d1\u751f\u8fdb\u5c55\u7684\u7edd\u7ecf\u540e\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002 Stemline\u8fd8\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5b9e\u73b0ELZONRIS\u00ae (tagraxofusp-erzs)\u7684\u5546\u4e1a\u5316\uff0c\u8fd9\u79cd\u9488\u5bf9CD123\u7684\u65b0\u578b\u9776\u5411\u6cbb\u7597\u836f\u7269\u9002\u7528\u4e8e\u6cbb\u7597\u4e00\u79cd\u4fb5\u88ad\u6027\u8840\u6db2\u764c\u2014\u2014\u6bcd\u7ec6\u80de\u6027\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u7ec6\u80de\u80bf\u7624(BPDCN)\u3002\u8fd9\u662f\u8fc4\u4eca\u552f\u4e00\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u83b7\u5f97\u6279\u51c6\u7684BPDCN\u6cbb\u7597\u836f\u7269\u3002\u00a0\u00a0Stemline\u8fd8\u5728\u6b27\u6d32\u5b9e\u73b0NEXPOVIO\u00ae (selinexor)\u7684\u5546\u4e1a\u5316\uff0c\u8fd9\u662f\u4e00\u79cd\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684XPO1\u6291\u5236\u5242\u3002 Stemline\u8fd8\u6709\u4f17\u591a\u5904\u4e8e\u4e0d\u540c\u5f00\u53d1\u9636\u6bb5\u4e14\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u548c\u8840\u6db2\u764c\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u5236\u5242\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\u3002<\/p>\n

SOURCE Menarini Industrie Farmaceutiche Riunite<\/p>","protected":false},"excerpt":{"rendered":"

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\u6b64\u5916\uff0c\u5bf9ELECTRA\u548cELEVATE\u4e24\u9879\u7814\u7a76\u7684\u60a3\u8005\u8fdb\u884c\u7684\u6c47\u603b\u5b89\u5168\u6027\u5206\u6790\u8868\u660e\uff0c\u5bf9\u4e8e\u5148\u524d\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u7ebf\u6cbb\u7597\u7684ER+\/HER2- mBC\u60a3\u8005\uff0c\u4f7f\u7528elacestrant\u4e0eabemaciclib\u8054\u5408\u6cbb\u7597\u8868\u73b0\u51fa\u53ef\u63a7\u4e14\u53ef\u9884\u6d4b\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002 \u6240\u6709\u63a5\u53d7\u8be5\u8054\u5408\u7528\u836f\u7684\u60a3\u8005\u90fd\u8fdb\u884c\u8fc7\u5b89\u5168\u6027\u8bc4\u4f30\uff0c\u7ed3\u679c\u4e0e\u4e24\u79cd\u5316\u5408\u7269\u7684\u5df2\u77e5\u5b89\u5168\u6027\u4e00\u81f4\u3002 \u6240\u6709\u7ea7\u522b\u4e2d\u6700\u5e38\u89c1(\u226520%)\u7684\u4e0d\u826f\u53cd\u5e94(AE)\u5305\u62ec\u8179\u6cfb\u3001\u6076\u5fc3\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5455\u5410\u3001\u75b2\u52b3\u3001\u8d2b\u8840\u4ee5\u53ca\u98df\u6b32\u51cf\u9000\u3002 \u672a\u89c2\u5bdf\u52304\u7ea7\u4e0d\u826f\u53cd\u5e94\u3002 \u5b8c\u6574\u6458\u8981(SESS-1910)\u53ef\u5728\u6b64\u5904\u67e5\u770b\uff08\u7b2c3330\u9875\uff09\u3002 \u201celacestrant\u4e0eabemaciclib\u8054\u5408\u7528\u836f\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\u6301\u7eed\u5448\u73b0\u79ef\u6781\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6570\u636e\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u800c\u4e14\u8fd9\u4e24\u79cd\u836f\u7269\u5728\u7528\u4e8e\u8054\u5408\u6cbb\u7597\u65f6\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u6bd2\u6027\u53cd\u5e94\uff0c\u201d\u533b\u5b66\u535a\u58eb\u3001\u533b\u5b66\u6559\u6388\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u4e73\u817a\u764c\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u6559\u80b2\u673a\u6784\u4e3b\u4efb\u517c\u4e73\u817a\u764c\u6559\u6388Hope S. Rugo\u8868\u793a\uff0c \u201celacestrant\u7ee7\u7eed\u5c55\u73b0\u51fa\u6709\u6f5c\u529b\u6210\u4e3a\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u8054\u5408\u65b9\u6848\u7684\u5185\u5206\u6ccc\u6cbb\u7597\u4e3b\u8981\u624b\u6bb5\uff0c\u968f\u7740\u8fd9\u4e9b\u8bd5\u9a8c\u53d6\u5f97\u8fdb\u5c55\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u6df1\u5165\u63a2\u7d22\u8fd9\u79cd\u6cbb\u7597\u7ec4\u5408\u3002\u201d \u201c\u89c1\u8bc1\u5728\u771f\u5b9e\u4e16\u754c\u73af\u5883\u4e2d\u53d6\u5f97\u8fd9\u6837\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6210\u679c\u4ee4\u4eba\u632f\u594b\uff0c\u8fd9\u8868\u660eORSERDU\u4f7f\u80bf\u7624\u79d1\u533b\u751f\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u5b9e\u8d28\u6027\u7684\u7597\u6548\uff0c\u201d\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u9996\u5e2d\u6267\u884c\u5b98Elcin Barker […]<\/p>\n","protected":false},"author":0,"featured_media":4945,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-4944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u5728\u4e73\u817a\u764c\u7814\u8ba8\u4f1a\u5c55\u793a\u6700\u65b0\u6570\u636e\u5de9\u56faORSERDU\u00ae (Elacestrant)\u7684\u4f5c\u7528 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u5728\u4e73\u817a\u764c\u7814\u8ba8\u4f1a\u5c55\u793a\u6700\u65b0\u6570\u636e\u5de9\u56faorserdu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2\u5728\u4e73\u817a\u764c\u7814\u8ba8\u4f1a\u5c55\u793a\u6700\u65b0\u6570\u636e\u5de9\u56faORSERDU\u00ae (Elacestrant)\u7684\u4f5c\u7528 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u771f\u5b9e\u8bc1\u636e\u652f\u6491ORSERDU\u5bf9\u4e8eER+\/HER2- ESR1\u7a81\u53d8\u665a\u671f\u6216mBC\u60a3\u8005\u7684\u7597\u6548\u3002\u65e0\u8bbaESR1\u7a81\u53d8\u72b6\u6001\u5982\u4f55\uff0celacestrant\u4e0eabemaciclib\u8054\u5408\u6cbb\u7597\u7684\u6700\u65b0\u7ed3\u679c\u5c55\u73b0\u51fa\u663e\u8457\u7684\u7597\u6548\uff0c\u5e76\u5728ER+\/HER2- mBC\u60a3\u8005\u4e2d\u5448\u73b0\u53ef\u63a7\u4e14\u53ef\u9884\u6d4b\u7684\u5b89\u5168\u6027\u3002 \u610f\u5927\u5229\u4f5b\u7f57\u4f26\u8428\u548c\u7ebd\u7ea62024\u5e7411\u670828\u65e5 \/\u7f8e\u901a\u793e\/ — \u9886\u5148\u7684\u8de8\u56fd\u5236\u836f\u53ca\u8bca\u65ad\u516c\u53f8\u7f8e\u7eb3\u91cc\u5c3c\u96c6\u56e2(“Menarini”)\uff0c\u4ee5\u53ca\u5176\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u60a3\u8005\u5f00\u53d1\u764c\u75c7\u8f6c\u5316\u7597\u6cd5\u7684\u5168\u8d44\u5b50\u516c\u53f8Stemline Therapeutics, Inc. 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ORSERDU\u662f\u7b2c\u4e00\u79cd\u4e14\u552f\u4e00\u4e00\u79cd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597ESR1\u7a81\u53d8\u80bf\u7624\u7684\u53e3\u670d\u96cc\u6fc0\u7d20\u53d7\u4f53\u62ee\u6297\u5242(SERD)\u3002\u8fd9\u7c7b\u7a81\u53d8\u80bf\u7624\u5728ER+\u3001HER2- \u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u4e2d\u7684\u53d1\u751f\u7387\u9ad8\u8fbe50%\uff0c\u539f\u56e0\u662f\u60a3\u8005\u5148\u524d\u5728\u764c\u75c7\u8f6c\u79fb\u7684\u60c5\u51b5\u4e0b\u63a5\u53d7\u8fc7\u5185\u5206\u6ccc\u6cbb\u7597(ET)\u3002 \u81ea2023\u5e741\u6708\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u6279\u51c6\u4ee5\u6765\uff0cORSERDU\u5df2\u79ef\u7d2f\u5145\u5206\u7684\u65f6\u95f4\uff0c\u5f97\u4ee5\u63cf\u8ff0\u5728\u5f53\u524d\u8f6c\u79fb\u6027\u4e73\u817a\u764c(mBC)\u6cbb\u7597\u9886\u57df\u4e2d\u7684\u771f\u5b9e\u4e16\u754c\u5e94\u7528\u60c5\u51b5\u3002 \u5373\u5c06\u5728SABCS 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\u201c\u8fd9\u4e9b\u6fc0\u52a8\u4eba\u5fc3\u7684\u6570\u636e\u663e\u793a\uff0cORSERDU\u5355\u836f\u6cbb\u7597\u53ef\u5b9e\u73b0\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u771f\u5b9e\u4e16\u754c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u201dUT Health San Antonio MD Anderson Cancer Center\u4e73\u817a\u80bf\u7624\u5b66\u5bb6\u517c\u533b\u5b66\u6559\u6388\u3001\u533b\u5b66\u535a\u58ebVirginia Kaklamani\u8868\u793a\uff0c \u201c\u4f5c\u4e3a\u6267\u4e1a\u533b\u5e08\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u6709\u5fc5\u8981\u4f7f\u7528\u6db2\u4f53\u6d3b\u68c0\u5728\u6bcf\u6b21\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u65f6\u68c0\u6d4b\u60a3\u8005\u80bf\u7624\u662f\u5426\u5b58\u5728ESR1\u7a81\u53d8\uff0c\u4ee5\u4fbf\u6211\u4eec\u80fd\u6070\u5f53\u5730\u4e3a\u60a3\u8005\u5b9a\u5236\u6cbb\u7597\u624b\u6bb5\uff0c\u5e76\u4f18\u5316\u5bf9\u5176\u7684\u62a4\u7406\u3002\u201d elacestrant\u4e0eabemaciclib\u8054\u5408\u7528\u836f\u7814\u7a76 ELEVATE\u548cELECTRA\u8fd9\u4e24\u98791b\/2\u671f\u7814\u7a76\u7684\u8bbe\u8ba1\u76ee\u6807\u662f\u901a\u8fc7\u8054\u5408\u6cbb\u7597\u7b56\u7565\u6765\u8bc4\u4f30\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\uff0c\u8fd9\u4e9b\u7b56\u7565\u65e8\u5728\u514b\u670d\u80bf\u7624\u5bf9\u5185\u5206\u6ccc\u6cbb\u7597(ET)\u7684\u8010\u836f\u6027\u3002 \u00a0 \u5373\u5c06\u5728SABCS 2024\u53d1\u5e03\u7684\u7814\u7a76\u7ed3\u679c\u5c06\u6db5\u76d6ELECTRA\u7814\u7a76\u7684\u6700\u65b0\u7597\u6548\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u5c55\u73b0\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u7684\u79ef\u6781\u8868\u73b0\u3002 \u5728\u6240\u6709\u80fd\u8bc4\u4f30\u7597\u6548\u7684\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(mPFS)\u4e3a8.6\u4e2a\u6708\u3002 \u5728\u53d1\u73b0ESR1\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\uff0cmPFS\u4e3a8.7\u4e2a\u6708\u3002 \u6ca1\u6709ESR1\u7a81\u53d8\u7684\u60a3\u8005\u7684mPFS\u4e3a7.2\u4e2a\u6708\u3002 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