{"id":5155,"date":"2024-12-03T11:39:00","date_gmt":"2024-12-03T11:39:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e7%88%b1%e4%bc%98%e7%89%b9%ef%bc%88%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib%ef%bc%89\/"},"modified":"2024-12-03T11:39:00","modified_gmt":"2024-12-03T11:39:00","slug":"%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e7%88%b1%e4%bc%98%e7%89%b9%ef%bc%88%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib%ef%bc%89","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e7%88%b1%e4%bc%98%e7%89%b9%ef%bc%88%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib%ef%bc%89\/","title":{"rendered":"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\/fruquintinib\uff09\u8054\u5408\u8fbe\u4f2f\u8212\u00ae 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rel=\"noopener\">\u548c\u9ec4\u533b\u836f<\/a>&#8220;\u6216&#8221;HUTCHMED&#8221;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u548cInnovent Biologics, Inc.\uff08\u7b80\u79f0&#8221;\u4fe1\u8fbe\u751f\u7269&#8221;\uff09\u4eca\u65e5\u8054\u5408\u5ba3\u5e03\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff0c\u544b\u55b9\u66ff\u5c3c\/ fruquintinib\uff09\u4e0e\u8fbe\u4f2f\u8212\u00ae\uff08TYVYT\u00ae\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\/ sintilimab 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class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/1870188\/HUTCHMED_Logo_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>\u6b64\u6b21\u56fd\u5bb6\u836f\u76d1\u5c40\u7684\u9644\u6761\u4ef6\u6279\u51c6\u662f\u57fa\u4e8eFRUSICA-1\u7814\u7a76\u6ce8\u518c\u9636\u6bb5\u7684\u6570\u636e\u652f\u6301\u3002FRUSICA-1\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b50\u5bab\u5185\u819c\u764c\u6ce8\u518c\u961f\u5217\uff0c\u65e8\u5728\u8bc4\u4f30\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\u6cbb\u7597\u542b\u94c2\u53cc\u836f\u5316\u7597\u6cbb\u7597\u540e\u75be\u75c5\u590d\u53d1\u3001\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002FRUSICA-1 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href=\"http:\/\/clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener\">clinicaltrials.gov<\/a>\uff0c\u68c0\u7d22\u6ce8\u518c\u53f7<a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT03903705\" target=\"_blank\" rel=\"noopener\">NCT03903705<\/a>\u67e5\u770b\u3002<\/p>\n<p>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u5987\u7624\u79d1\u4e3b\u4efb\u3001FRUSICA-1 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href=\"https:\/\/clinicaltrials.gov\/study\/NCT06584032\" target=\"_blank\" rel=\"noopener\">NCT06584032<\/a>\uff09\u3002<\/p>\n<p>\u5173\u4e8e\u5b50\u5bab\u5185\u819c\u764c<\/p>\n<p>\u5b50\u5bab\u5185\u819c\u764c\u662f\u4e00\u79cd\u59cb\u4e8e\u5b50\u5bab\u7684\u764c\u75c7\uff0c\u4e14\u4ecd\u7136\u662f\u4e00\u4e2a\u91cd\u5927\u7684\u5168\u7403\u5065\u5eb7\u6311\u6218\u3002\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c2020\u5e74\u4f30\u8ba1\u65b0\u589e417,000\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u65b0\u75c7\uff0c\u5e76\u9020\u6210\u7ea697,000\u4eba\u6b7b\u4ea1\u3002[2] \u5728\u4e2d\u56fd\uff0c2020\u5e74\u4f30\u8ba1\u65b0\u589e82,000\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u65b0\u75c7\uff0c\u5e76\u9020\u6210\u7ea617,000\u4eba\u6b7b\u4ea1\u3002[3]\u00a0\u5c3d\u7ba1\u65e9\u671f\u5b50\u5bab\u5185\u819c\u764c\u4e00\u822c\u53ef\u4ee5\u901a\u8fc7\u624b\u672f\u5207\u9664\uff0c\u4f46\u590d\u53d1\u6027\u548c\/\u6216\u8f6c\u79fb\u6027\u5b50\u5bab\u5185\u819c\u764c\u9886\u57df\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u672a\u6ee1\u8db3\u7684\u9700\u6c42\uff0c\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\u4e0d\u4f73\u4e14\u6cbb\u7597\u9009\u62e9\u6709\u9650\u3002[4],[5],[6]<\/p>\n<p>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c<\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7684\u53e3\u670d\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;VEGFR&#8221;\uff09-1\u3001-2\u53ca-3\u6291\u5236\u5242\u3002VEGFR\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u544b\u55b9\u66ff\u5c3c\u88ab\u8bbe\u8ba1\u4e3a\u62e5\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9009\u62e9\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u8131\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u3001\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u8986\u76d6\u4ee5\u53ca\u5f53\u6f5c\u5728\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u65f6\u62e5\u6709\u66f4\u9ad8\u7684\u7075\u6d3b\u5ea6\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u544b\u55b9\u66ff\u5c3c\u5c55\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5176\u4e0e\u5176\u4ed6\u6297\u80bf\u7624\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u7684\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u83b7\u6279<\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u5df2\u4e8e\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08&#8221;VEGF&#8221;\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;EGFR&#8221;\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5e76\u7531\u548c\u9ec4\u533b\u836f\u53ca\u793c\u6765\u5408\u4f5c\u7814\u53d1\u53ca\u4ee5\u5546\u54c1\u540d\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff09\u4e0a\u5e02\u9500\u552e\u3002\u5176\u4e8e2020\u5e741\u6708\u83b7\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u81ea\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\u4ee5\u6765\u5df2\u60e0\u53ca\u8d85\u8fc710\u4e07\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002<\/p>\n<p>\u6b66\u7530\u62e5\u6709\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u95e8\u4ee5\u5916\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u751f\u4ea7\u544b\u55b9\u66ff\u5c3c\u7684\u5168\u7403\u72ec\u5bb6\u8bb8\u53ef\uff0c\u5e76\u4ee5\u5546\u54c1\u540dFRUZAQLA\u00ae\u4e0a\u5e02\u9500\u552e\u3002\u544b\u55b9\u66ff\u5c3c\u4e8e2023\u5e7411\u6708<a href=\"https:\/\/www.hutch-med.com\/sc\/us-fda-approval-of-fruzaqla-fruquintinib\/\" target=\"_blank\" rel=\"noopener\">\u5728\u7f8e\u56fd<\/a>\u30012024\u5e746\u6708<a href=\"https:\/\/www.hutch-med.com\/sc\/european-commission-approval-for-fruzaqla-fruquintinib\/\" target=\"_blank\" rel=\"noopener\">\u5728\u6b27\u76df<\/a>\u30012024\u5e748\u6708\u5728\u745e\u58eb\u30012024\u5e749\u6708\u5728\u52a0\u62ff\u5927\u3001<a href=\"https:\/\/www.hutch-med.com\/sc\/japan-approval-for-fruzaqla-fruquintinib\/\" target=\"_blank\" rel=\"noopener\">\u65e5\u672c<\/a>\u548c\u82f1\u56fd\uff0c\u4ee5\u53ca\u4e8e2024\u5e7410\u6708\u5728\u963f\u6839\u5ef7\u3001\u6fb3\u6d32\u548c\u65b0\u52a0\u5761\u83b7\u6279\u3002\u5728\u5176\u4ed6\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u76d1\u7ba1\u7533\u8bf7\u4ea6\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p>\u5411\u5168\u7403\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u7684\u6ce8\u518c\u7533\u8bf7\u662f\u57fa\u4e8e\u4e24\u9879\u5927\u578b\u3001\u968f\u673a\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5373\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8cFRESCO-2\u7814\u7a76\u4ee5\u53ca\u4e8e\u4e2d\u56fd\u5f00\u5c55\u7684FRESCO\u7814\u7a76\uff0c\u5728\u603b\u5171734\u540d\u63a5\u53d7\u544b\u55b9\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u4e86\u4e00\u81f4\u7684\u83b7\u76ca\u3002\u5404\u9879\u7814\u7a76\u7684\u5b89\u5168\u6027\u7279\u5f81\u4ea6\u4fdd\u6301\u4e00\u81f4\u3002FRESCO-2\u7814\u7a76\u7684\u7ed3\u679c\u5df2\u57282023\u5e746\u6708\u4e8e\u300a\u67f3\u53f6\u5200\uff08The Lancet\uff09\u300b<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(23)00772-9\/fulltext\" target=\"_blank\" rel=\"noopener\">\u53d1\u8868<\/a>\uff0c[7]\u00a0FRESCO\u7814\u7a76\u7684\u7ed3\u679c\u5219\u5df2\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\uff08JAMA\uff09\u300b\u4e0a<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2685988\" target=\"_blank\" rel=\"noopener\">\u53d1\u8868<\/a>\u3002[8]<\/p>\n<p>\u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u5177\u6709\u56fd\u9645\u54c1\u8d28\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684\u00a0PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u542f\u52a8\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u00a0\u3002[9]<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u5e76\u7eb3\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e03\u9879\u9002\u5e94\u75c7\uff0c\u534f\u8bae\u671f\u5185\u533b\u4fdd\u76ee\u5f55\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u8303\u56f4\u5305\u62ec\uff1a<\/p>\n<p>\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9634\u6027\u3001 \u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09 \u6cbb\u7597\u5931\u8d25\u7684 EGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff1b\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u516b\u9879\u9002\u5e94\u75c7\uff0c\u5373\u4e0e\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e2024\u5e7412\u6708\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u53e6\u6709\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a<\/p>\n<p>\u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u58f0\u660e\uff1a\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/p>\n<p>\u5173\u4e8e\u548c\u9ec4\u533b\u836f<\/p>\n<p>\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u96c6\u56e2\u65d7\u4e0b\u516c\u53f8\u5171\u6709\u7ea65,000\u540d\u5458\u5de5\uff0c\u5176\u4e2d\u6838\u5fc3\u7684\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u62e5\u6709\u7ea61,800\u4eba\u7684\u56e2\u961f\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u6297\u80bf\u7624\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1a<a href=\"https:\/\/www.hutch-med.com\/sc\" target=\"_blank\" rel=\"noopener\">www.hutch\u2011med.com<\/a>\u6216\u5173\u6ce8\u6211\u4eec\u7684<a href=\"https:\/\/www.linkedin.com\/company\/hutchmed\/\" target=\"_blank\" rel=\"noopener\">\u9886\u82f1<\/a>\u4e13\u9875\u3002<\/p>\n<p>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/p>\n<p>&#8220;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&#8221;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u4ee3\u8c22\u53ca\u5fc3\u8840\u7ba1\u3001\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u5df2\u670911\u6b3e\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u540c\u65f6\u8fd8\u67095\u4e2a\u54c1\u79cd\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u8bc4\u4e2d\uff0c3\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670917\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u4e0e\u6d77\u5185\u5916\u836f\u4f01\u6df1\u5165\u5408\u4f5c\u52a0\u901f\u836f\u7269\u521b\u65b0\uff0c\u4e0e\u793c\u6765\u3001\u8d5b\u8bfa\u83f2\u3001Incyte\u3001Adimab\u3001LG Chem\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u591a\u9879\u6218\u7565\u5408\u4f5c\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u5f00\u53d1\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88&#8221;\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3&#8221;\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a href=\"https:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7\u3002<\/p>\n<p>\u524d\u77bb\u6027\u9648\u8ff0<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b1995\u5e74\u300a\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b&#8221;\u5b89\u5168\u6e2f&#8221;\u6761\u6b3e\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\u53cd\u6620\u4e86\u548c\u9ec4\u533b\u836f\u76ee\u524d\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u9884\u671f\uff0c\u5305\u62ec\u5bf9\u544b\u55b9\u66ff\u5c3c\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6f5c\u529b\u7684\u9884\u671f\uff0c\u4ee5\u53ca\u544b\u55b9\u66ff\u5c3c\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u6b21\u9002\u5e94\u75c7\u53ca\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u3002\u524d\u77bb\u6027\u9648\u8ff0\u6d89\u53ca\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u6b64\u7c7b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4e0b\u5217\u5047\u8bbe\uff1a\u652f\u6301\u544b\u55b9\u66ff\u5c3c\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5728\u4e2d\u56fd\u6216\u5176\u4ed6\u5730\u533a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u7684\u6570\u636e\u5145\u8db3\u6027\u3001\u544b\u55b9\u66ff\u5c3c\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3001\u548c\u9ec4\u533b\u836f\u4e3a\u544b\u55b9\u66ff\u5c3c\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u53ca\u5546\u4e1a\u5316\u63d0\u4f9b\u8d44\u91d1\u5e76\u5b9e\u73b0\u53ca\u5b8c\u6210\u7684\u80fd\u529b\uff0c\u4ee5\u53ca\u6b64\u7c7b\u4e8b\u4ef6\u53d1\u751f\u7684\u65f6\u95f4\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u90e8\u5206\u7814\u7a76\u8d56\u4e8e\u628a\u5176\u4ed6\u836f\u7269\u4ea7\u54c1\uff08\u5982\u4fe1\u8fea\u5229\u5355\u6297\uff09\u4e0e\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4f7f\u7528\uff0c\u56e0\u6b64\u6b64\u7c7b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u6709\u5173\u8fd9\u4e9b\u6cbb\u7597\u836f\u7269\u7684\u5b89\u5168\u6027\u3001\u7597\u6548\u3001\u4f9b\u5e94\u548c\u76d1\u7ba1\u6279\u51c6\u7684\u5047\u8bbe\u3002\u5f53\u524d\u548c\u6f5c\u5728\u6295\u8d44\u8005\u8bf7\u52ff\u8fc7\u5ea6\u4f9d\u8d56\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u8fd9\u4e9b\u9648\u8ff0\u4ec5\u5728\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u5f53\u65e5\u6709\u6548\u3002\u5f53\u524d\u548c\u6f5c\u5728\u6295\u8d44\u8005\u8bf7\u52ff\u8fc7\u5ea6\u4f9d\u8d56\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u8fd9\u4e9b\u9648\u8ff0\u4ec5\u5728\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u5f53\u65e5\u6709\u6548\u3002\u6709\u5173\u8fd9\u4e9b\u98ce\u9669\u548c\u5176\u4ed6\u98ce\u9669\u7684\u8fdb\u4e00\u6b65\u8ba8\u8bba\uff0c\u8bf7\u67e5\u9605\u548c\u9ec4\u533b\u836f\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u3001\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4ee5\u53caAIM\u63d0\u4ea4\u7684\u6587\u4ef6\u3002\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8baf\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u60c5\u51b5\u6216\u5176\u4ed6\u56e0\u7d20\uff0c\u548c\u9ec4\u533b\u836f\u5747\u4e0d\u627f\u62c5\u66f4\u65b0\u6216\u4fee\u8ba2\u672c\u65b0\u95fb\u7a3f\u6240\u542b\u8baf\u606f\u7684\u4e49\u52a1\u3002<\/p>\n<p>\u533b\u7597\u4fe1\u606f<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u63d0\u5230\u7684\u4ea7\u54c1\u53ef\u80fd\u5e76\u672a\u5728\u6240\u6709\u56fd\u5bb6\u4e0a\u5e02\uff0c\u6216\u53ef\u80fd\u4ee5\u4e0d\u540c\u7684\u5546\u6807\u8fdb\u884c\u9500\u552e\uff0c\u6216\u7528\u4e8e\u4e0d\u540c\u7684\u75c5\u75c7\uff0c\u6216\u91c7\u7528\u4e0d\u540c\u7684\u5242\u91cf\uff0c\u6216\u62e5\u6709\u4e0d\u540c\u7684\u6548\u529b\u3002\u672c\u6587\u4e2d\u6240\u5305\u542b\u7684\u4efb\u4f55\u4fe1\u606f\u90fd\u4e0d\u5e94\u88ab\u770b\u4f5c\u662f\u4efb\u4f55\u5904\u65b9\u836f\u7684\u7533\u8bf7\u3001\u63a8\u5e7f\u6216\u5e7f\u544a\uff0c\u5305\u62ec\u90a3\u4e9b\u6b63\u5728\u7814\u53d1\u7684\u836f\u7269\u3002<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0\u00a0\u00a0\u00a0 Wu X, et al. Fruquintinib plus sintilimab in treated advanced endometrial cancer (EMC) patients (pts) with PMMR status: Results from a multicenter, single-arm phase 2 study. J Clin Oncol\u00a042, 2024 (suppl 16; abstr 5619). DOI: 10.1200\/JCO.2024.42.16_suppl.5619.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u00a0\u00a0\u00a0\u00a0 <a class=\"prnews_a\" href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" rel=\"noopener\">The Global Cancer Observatory<\/a>, <a class=\"prnews_a\" href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/900-world-fact-sheets.pdf\" target=\"_blank\" rel=\"noopener\">World Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]\u00a0\u00a0\u00a0\u00a0 <a class=\"prnews_a\" href=\"https:\/\/gco.iarc.fr\/\" target=\"_blank\" rel=\"noopener\">The Global Cancer Observatory<\/a>, <a class=\"prnews_a\" href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" target=\"_blank\" rel=\"noopener\">China Fact Sheet<\/a>. Accessed June 12, 2023.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]\u00a0\u00a0\u00a0\u00a0 Yi A, et al. Real-world characteristics and treatment pattern of patients with newly diagnosed endometrial cancer in China.\u00a0 J Clin Oncol. 2023;41, no. 16_suppl (June 01, 2023) e17613-e17613. DOI: 10.1200\/JCO.2023.41.16_suppl.e17613.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]\u00a0\u00a0\u00a0\u00a0 Koppikar S, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer. ESMO Open. 2023;8(1):100774. DOI: 10.1016\/j.esmoop.2022.100774.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[6]\u00a0\u00a0\u00a0\u00a0 Siegel RL, et al. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17-48. DOI:10.3322\/caac.21763.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[7]\u00a0\u00a0\u00a0\u00a0 Dasari NA, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO\u20112): an international, multicentre, randomised, double\u2011blind, Phase III study. Lancet. 2023;402(10395):41\u201153. doi:10.1016\/S0140\u20116736(23)00772\u20119.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[8]\u00a0\u00a0\u00a0\u00a0 Li J, et al. Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial. JAMA. 2018;319(24):2486-2496. DOI:10.1001\/jama.2018.7855.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[9]\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. DOI: 10.1080\/19420862.2019.1654303.<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>SOURCE  \u548c\u9ec4\u533b\u836f(\u4e2d\u56fd)\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"<p>\u2014 \u544b\u55b9\u66ff\u5c3c\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u7597\u6cd5\u53d6\u5f97\u7684\u9996\u4e2a\u76d1\u7ba1\u6ce8\u518c\u6279\u51c6 \u2014 \u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde2024\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0&#8221;\u548c\u9ec4\u533b\u836f&#8220;\u6216&#8221;HUTCHMED&#8221;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u548cInnovent Biologics, Inc.\uff08\u7b80\u79f0&#8221;\u4fe1\u8fbe\u751f\u7269&#8221;\uff09\u4eca\u65e5\u8054\u5408\u5ba3\u5e03\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff0c\u544b\u55b9\u66ff\u5c3c\/ 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