{"id":5292,"date":"2024-12-06T03:00:00","date_gmt":"2024-12-06T03:00:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/"},"modified":"2024-12-06T03:00:00","modified_gmt":"2024-12-06T03:00:00","slug":"%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/","title":{"rendered":"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e"},"content":{"rendered":"

I\/IIa\u671f\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cDB-1311\/BNT324\u5728\u65e2\u5f80\u7ecf\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff08\u5982SCLC\u3001NSCLC\u548cCRPC\uff09\uff0c\u663e\u793a\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff1b\u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\uff0c\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0cuORR\u4e3a70.4%\uff1b\u5728CRPC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a28.0%\uff0c\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708, 6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u8ba1\u5212\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30DB-1311\/BNT324\u4e0eBNT327\/PM8002\uff08PD-L1\/VEGF-A\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u7684\u8054\u5408\u4f7f\u7528\uff1b\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597 SCLC \u6216 NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e 2025 \u5e74\u542f\u52a8\u3002<\/p>\n

\u65b0\u6cfd\u897f\u5dde\u666e\u6797\u65af\u987f\u3001\u4e0a\u6d77\u548c\u82cf\u5dde<\/span>2024\u5e7412\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — Duality Biologics\uff08”\u6620\u6069\u751f\u7269”\uff09\u4eca\u65e5\u516c\u5e03\u4e86DB-1311\/BNT324\uff08\u9776\u5411B7H3\u7684\u521b\u65b0ADC\u5206\u5b50\uff09\u5168\u7403I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff0cCTR20232835\uff09\u7684\u9996\u6279\u6570\u636e\u3002\u8be5\u6570\u636e\u5728\u65b0\u52a0\u5761\u53ec\u5f00\u76842024\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e9a\u6d32\u5e74\u4f1a\uff08ESMO Asia\uff09\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u62ab\u9732\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002DB-1311\/BNT324 \u7531\u00a0\u6620\u6069\u751f\u7269\u548cBioNTech SE\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aBNTX\uff0c”BioNTech”\uff09\u5171\u540c\u5f00\u53d1\u3002<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

\u622a\u81f32024\u5e7409\u670827\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7ec4277\u4f8b\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u80bf\u7624\u7c7b\u578b\u5305\u62ec\u4f46\u4e0d\u9650\u4e8eSCLC\u3001NSCLC\u3001CRPC\u4ee5\u53caHNSCC\uff0c\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5171\u5165\u7ec4130\u4f8b\uff0c\u7ea6\u536047%\u3002ECOG\u8bc4\u5206\u4e3a1\u7684\u60a3\u8005\u7ea6\u536075%\uff0c\u63a5\u53d7\u8fc72\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u7ea6\u536061%\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u548c\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aDoR\u3001DCR\u3001PFS\u3001OS\u7b49\u3002\u7814\u7a76\u7ed3\u679c\u5177\u4f53\u5982\u4e0b\uff1a<\/p>\n

\u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff08n=238\uff09\uff0c\u603b\u4f53uORR\u4e3a32.4%\uff0cDCR\u4e3a82.4%\u3002SCLC\u60a3\u8005\u4e2d\uff08n=73\uff09\uff0cuORR\u4e3a56.2%\uff0cDCR\u4e3a89.0%\u3002\u7edd\u5927\u90e8\u5206SCLC\u60a3\u8005\u63a5\u53d7\u4e866 mg\/kg\u548c9 mg\/kg DB-1311\/BNT324\u6cbb\u7597\uff0c\u4e24\u7ec4\u4e4b\u95f4uORR\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u5206\u522b\u4e3a54.5%\u548c58.8%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a70.4%\u3002NSCLC\u60a3\u8005\u4e2d\uff0c\u5927\u90e8\u5206\u4e3a\u975e\u9cde\u764c\uff08n=41\uff09\uff0cuORR\u4e3a22.0%\uff1b\u9cde\u764c\u60a3\u8005\uff08n=25\uff09\uff0c<\/span>uORR\u4e3a16.0%\u3002CRPC\u60a3\u8005\u4e2d\uff08n=32\uff09\uff0cDB-1311\/BNT324\u8868\u73b0\u51fa\u65e9\u671f\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u4e3a28.0%\uff0cDCR\u4e3a92.0%\uff0crPFS\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708\uff0c6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u5176\u4ed6\u7624\u79cd\u4e2d\uff0c\u5982\u5bab\u9888\u764c\uff08n=4\uff09\u3001\u809d\u7ec6\u80de\u764c\uff08n=12\uff09\u3001\u5934\u9888\u90e8\u9cde\u764c\uff08n=3\uff09\u548c\u9ed1\u8272\u7d20\u7624\uff08n=11\uff09\uff0cDB-1311\/BNT324\u540c\u6837\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u5206\u522b\u4e3a75.0%\u300125.0%\u3001100.0%\u548c36.4%\u3002DB-1311\/BNT324\u5728\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u80bf\u7624\u60a3\u8005\u4e2d\uff08n=277\uff09\u8868\u73b0\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002\u6700\u5e38\u89c1\u7684TRAE\u4e3a\u6076\u5fc3\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u98df\u6b32\u964d\u4f4e\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3002<\/p>\n

\u6620\u6069\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6731\u5fe0\u8fdc\u535a\u58eb\u8868\u793a\uff1a”DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u4e0eBioNTech\u5171\u540c\u5f00\u53d1\u7684\u521b\u65b0ADC\u5206\u5b50\uff0c\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u9636\u6bb5\uff0c\u5176\u4e34\u5e8a\u6570\u636e\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u6620\u6069\u751f\u7269\u7684ADC\u6280\u672f\u5e73\u53f0\u53ef\u6301\u7eed\u5f00\u53d1\u51fa\u66f4\u591a\u65b0\u578bADC\u836f\u7269\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u4e30\u5bcc\u7684\u4e34\u5e8a\u89e3\u51b3\u65b9\u6848\uff0c\u8df5\u884c\u6620\u6069\u751f\u7269\u4e0d\u65ad\u63a2\u7d22\u521b\u65b0\u7597\u6cd5\u7684\u4fe1\u5ff5\uff0c\u5171\u540c\u63a8\u52a8\u5168\u7403ADC\u4ea7\u4e1a\u7684\u53d1\u5c55\uff0c\u60e0\u53ca\u75c5\u60a3\u3002”<\/p>\n

DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u548c\u00a0BioNTech\u5168\u7403\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u4e2d\u4e09\u4e2a\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u00a0ADC \u5019\u9009\u836f\u7269\u4e4b\u4e00\uff0c\u65e8\u5728\u63a8\u52a8\u8fd9\u4e9b\u65b0\u578b\u00a0ADC \u8fdb\u5165\u591a\u4e2a\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u764c\u75c7\u7684\u540e\u671f\u5f00\u53d1\u9636\u6bb5\u3002BNT327\/PM8002 \u662f\u65b0\u578b\u9776\u5411\u00a0PD-L1 \u548cVEGF-A \u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7531BioNTech\u548c\u666e\u7c73\u65af\u751f\u7269\u5171\u540c\u5f00\u53d1\u3002\u76ee\u524d\uff0c\u8bc4\u4f30\u00a0TROP2 ADC\uff08DB-1305\/BNT325\uff09\u548c\u00a0BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u53e6\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u00a0SCLC \u6216\u00a0NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e\u00a02025 \u5e74\u542f\u52a8\u3002<\/p>\n

###<\/p>\n

\u5173\u4e8eDB-1311\/BNT324<\/p>\n

DB-1311\/BNT324\u662f\u57fa\u4e8e\u6620\u6069\u751f\u7269\u72ec\u521b\u7684DITAC\u6280\u672f\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3ADC\u4ea7\u54c1\u3002\u5b83\u5728\u4ee3\u8868\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u4e00\u7cfb\u5217\u80bf\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5e76\u4e14\u5728\u4e34\u5e8a\u524d\u5b89\u5168\u8bc4\u4f30\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u4e34\u5e8a\u524d\u6297\u80bf\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5c55\u793aDB-1311\/BNT324\u5728\u672a\u6765\u5e94\u7528\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u6cbb\u7597\u7a97\u53e3\uff0c\u5c06\u6709\u53ef\u80fd\u4e3a\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n

DB-1311\/BNT324 \u662f\u4e00\u79cd\u57fa\u4e8e\u62d3\u6251\u5f02\u6784\u9176 I \u6291\u5236\u5242\u7684\u9776\u5411B7H3\u521b\u65b0 ADC\u5206\u5b50\u3002\u8de8\u819c\u7cd6\u86cb\u767d B7-H3 \u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f62\u6210\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u5b83\u5728\u5f88\u591a\u5b9e\u4f53\u7624\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u6709\u9650\uff0c\u4e0e\u75be\u75c5\u8fdb\u5c55\u548c\u9884\u540e\u6781\u5dee\u6709\u5173[1]<\/span>\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cDB-1311\/BNT324\u5728\u5404\u79cd\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027[2]<\/span>\u3002\u6b63\u5728\u8fdb\u884c\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff09\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cDB-1311\/BNT324\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002<\/p>\n

2024 \u5e74\u00a06 \u6708\uff0cFDA\u6388\u4e88DB-1311\/ BNT324\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\/\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u30022024 \u5e74\u00a07 \u6708\uff0cFDA \u6388\u4e88\u00a0DB-1311\/BNT324 \u5b64\u513f\u836f\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u3002<\/p>\n

\u5173\u4e8e\u6620\u6069\u751f\u7269\u00a0<\/p>\n

\u6620\u6069\u751f\u7269\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u521b\u65b0\u751f\u7269\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u764c\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u7b49\u75be\u75c5\u60a3\u8005\u7814\u53d1\u65b0\u4e00\u4ee3ADC\u6cbb\u7597\u836f\u7269\u3002\u6620\u6069\u751f\u7269\u5df2\u6210\u529f\u6784\u5efa\u4e86\u591a\u4e2a\u5177\u6709\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u7684\u65b0\u4e00\u4ee3ADC\u6280\u672f\u5e73\u53f0\u3002\u57fa\u4e8e\u5bf9\u75be\u75c5\u751f\u7269\u5b66\u673a\u5236\u7684\u6df1\u5165\u7814\u7a76\u548c\u63a2\u7d22\uff0c\u6620\u6069\u751f\u7269\u62e5\u6709\u591a\u4e2a\u4e34\u5e8a\u9636\u6bb5ADC\u5019\u9009\u836f\u7269\uff0c\u5e76\u5728\u8d85\u8fc717\u4e2a\u56fd\u5bb6\u5f00\u5c55\u591a\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5165\u7ec4\u8d85\u8fc71,000\u591a\u540d\u60a3\u8005\u3002\u6b64\u5916\uff0c\u6620\u6069\u751f\u7269\u6b63\u5728\u7ee7\u7eed\u7814\u53d1\u5176\u65b0\u578b\u86cb\u767d\u8d28\u5de5\u7a0b\u548cADC\u6280\u672f\uff0c\u4ee5\u5f00\u53d1\u4e0b\u4e00\u4ee3”\u8d85\u7ea7ADC”\u5206\u5b50\uff0c\u5305\u62ec\u53cc\u7279\u5f02\u6027ADC\uff0c\u5168\u65b0\u673a\u5236\u8f7d\u8377ADC\u548c\u81ea\u514dADC\u3002<\/p>\n

\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8054\u7cfb\uff1aIR@dualitybiologics.com<\/a><\/p>\n

\n

\u53c2\u8003\u6587\u732e<\/span><\/p>\n

[1]\u00a0Ranjana K. Kanchan, et al. Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188783.<\/span><\/p>\n

[2] Li C, Yao J, et al. Cancer Res (2023) 83 (7_Supplement): 2967.<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

\u00a0<\/p>\n

\u00a0<\/p>\n

\u00a0<\/p>\n\n

SOURCE \u6620\u6069\u751f\u7269<\/p>","protected":false},"excerpt":{"rendered":"

I\/IIa\u671f\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cDB-1311\/BNT324\u5728\u65e2\u5f80\u7ecf\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff08\u5982SCLC\u3001NSCLC\u548cCRPC\uff09\uff0c\u663e\u793a\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff1b\u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\uff0c\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0cuORR\u4e3a70.4%\uff1b\u5728CRPC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a28.0%\uff0c\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708, 6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u8ba1\u5212\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30DB-1311\/BNT324\u4e0eBNT327\/PM8002\uff08PD-L1\/VEGF-A\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u7684\u8054\u5408\u4f7f\u7528\uff1b\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597 SCLC \u6216 NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e 2025 \u5e74\u542f\u52a8\u3002 \u65b0\u6cfd\u897f\u5dde\u666e\u6797\u65af\u987f\u3001\u4e0a\u6d77\u548c\u82cf\u5dde2024\u5e7412\u67086\u65e5 \/\u7f8e\u901a\u793e\/ — Duality Biologics\uff08”\u6620\u6069\u751f\u7269”\uff09\u4eca\u65e5\u516c\u5e03\u4e86DB-1311\/BNT324\uff08\u9776\u5411B7H3\u7684\u521b\u65b0ADC\u5206\u5b50\uff09\u5168\u7403I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff0cCTR20232835\uff09\u7684\u9996\u6279\u6570\u636e\u3002\u8be5\u6570\u636e\u5728\u65b0\u52a0\u5761\u53ec\u5f00\u76842024\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e9a\u6d32\u5e74\u4f1a\uff08ESMO Asia\uff09\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u62ab\u9732\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002DB-1311\/BNT324 \u7531\u00a0\u6620\u6069\u751f\u7269\u548cBioNTech SE\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aBNTX\uff0c”BioNTech”\uff09\u5171\u540c\u5f00\u53d1\u3002 \u622a\u81f32024\u5e7409\u670827\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7ec4277\u4f8b\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u80bf\u7624\u7c7b\u578b\u5305\u62ec\u4f46\u4e0d\u9650\u4e8eSCLC\u3001NSCLC\u3001CRPC\u4ee5\u53caHNSCC\uff0c\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5171\u5165\u7ec4130\u4f8b\uff0c\u7ea6\u536047%\u3002ECOG\u8bc4\u5206\u4e3a1\u7684\u60a3\u8005\u7ea6\u536075%\uff0c\u63a5\u53d7\u8fc72\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u7ea6\u536061%\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u548c\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aDoR\u3001DCR\u3001PFS\u3001OS\u7b49\u3002\u7814\u7a76\u7ed3\u679c\u5177\u4f53\u5982\u4e0b\uff1a \u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff08n=238\uff09\uff0c\u603b\u4f53uORR\u4e3a32.4%\uff0cDCR\u4e3a82.4%\u3002SCLC\u60a3\u8005\u4e2d\uff08n=73\uff09\uff0cuORR\u4e3a56.2%\uff0cDCR\u4e3a89.0%\u3002\u7edd\u5927\u90e8\u5206SCLC\u60a3\u8005\u63a5\u53d7\u4e866 mg\/kg\u548c9 mg\/kg DB-1311\/BNT324\u6cbb\u7597\uff0c\u4e24\u7ec4\u4e4b\u95f4uORR\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u5206\u522b\u4e3a54.5%\u548c58.8%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a70.4%\u3002NSCLC\u60a3\u8005\u4e2d\uff0c\u5927\u90e8\u5206\u4e3a\u975e\u9cde\u764c\uff08n=41\uff09\uff0cuORR\u4e3a22.0%\uff1b\u9cde\u764c\u60a3\u8005\uff08n=25\uff09\uff0cuORR\u4e3a16.0%\u3002CRPC\u60a3\u8005\u4e2d\uff08n=32\uff09\uff0cDB-1311\/BNT324\u8868\u73b0\u51fa\u65e9\u671f\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u4e3a28.0%\uff0cDCR\u4e3a92.0%\uff0crPFS\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708\uff0c6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u5176\u4ed6\u7624\u79cd\u4e2d\uff0c\u5982\u5bab\u9888\u764c\uff08n=4\uff09\u3001\u809d\u7ec6\u80de\u764c\uff08n=12\uff09\u3001\u5934\u9888\u90e8\u9cde\u764c\uff08n=3\uff09\u548c\u9ed1\u8272\u7d20\u7624\uff08n=11\uff09\uff0cDB-1311\/BNT324\u540c\u6837\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u5206\u522b\u4e3a75.0%\u300125.0%\u3001100.0%\u548c36.4%\u3002DB-1311\/BNT324\u5728\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u80bf\u7624\u60a3\u8005\u4e2d\uff08n=277\uff09\u8868\u73b0\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002\u6700\u5e38\u89c1\u7684TRAE\u4e3a\u6076\u5fc3\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u98df\u6b32\u964d\u4f4e\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3002 \u6620\u6069\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6731\u5fe0\u8fdc\u535a\u58eb\u8868\u793a\uff1a”DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u4e0eBioNTech\u5171\u540c\u5f00\u53d1\u7684\u521b\u65b0ADC\u5206\u5b50\uff0c\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u9636\u6bb5\uff0c\u5176\u4e34\u5e8a\u6570\u636e\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u6620\u6069\u751f\u7269\u7684ADC\u6280\u672f\u5e73\u53f0\u53ef\u6301\u7eed\u5f00\u53d1\u51fa\u66f4\u591a\u65b0\u578bADC\u836f\u7269\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u4e30\u5bcc\u7684\u4e34\u5e8a\u89e3\u51b3\u65b9\u6848\uff0c\u8df5\u884c\u6620\u6069\u751f\u7269\u4e0d\u65ad\u63a2\u7d22\u521b\u65b0\u7597\u6cd5\u7684\u4fe1\u5ff5\uff0c\u5171\u540c\u63a8\u52a8\u5168\u7403ADC\u4ea7\u4e1a\u7684\u53d1\u5c55\uff0c\u60e0\u53ca\u75c5\u60a3\u3002” DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u548c\u00a0BioNTech\u5168\u7403\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u4e2d\u4e09\u4e2a\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u00a0ADC \u5019\u9009\u836f\u7269\u4e4b\u4e00\uff0c\u65e8\u5728\u63a8\u52a8\u8fd9\u4e9b\u65b0\u578b\u00a0ADC \u8fdb\u5165\u591a\u4e2a\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u764c\u75c7\u7684\u540e\u671f\u5f00\u53d1\u9636\u6bb5\u3002BNT327\/PM8002 \u662f\u65b0\u578b\u9776\u5411\u00a0PD-L1 \u548cVEGF-A \u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7531BioNTech\u548c\u666e\u7c73\u65af\u751f\u7269\u5171\u540c\u5f00\u53d1\u3002\u76ee\u524d\uff0c\u8bc4\u4f30\u00a0TROP2 ADC\uff08DB-1305\/BNT325\uff09\u548c\u00a0BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u53e6\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u00a0SCLC \u6216\u00a0NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e\u00a02025 \u5e74\u542f\u52a8\u3002 ### \u5173\u4e8eDB-1311\/BNT324 DB-1311\/BNT324\u662f\u57fa\u4e8e\u6620\u6069\u751f\u7269\u72ec\u521b\u7684DITAC\u6280\u672f\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3ADC\u4ea7\u54c1\u3002\u5b83\u5728\u4ee3\u8868\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u4e00\u7cfb\u5217\u80bf\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5e76\u4e14\u5728\u4e34\u5e8a\u524d\u5b89\u5168\u8bc4\u4f30\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u4e34\u5e8a\u524d\u6297\u80bf\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5c55\u793aDB-1311\/BNT324\u5728\u672a\u6765\u5e94\u7528\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u6cbb\u7597\u7a97\u53e3\uff0c\u5c06\u6709\u53ef\u80fd\u4e3a\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002 DB-1311\/BNT324 \u662f\u4e00\u79cd\u57fa\u4e8e\u62d3\u6251\u5f02\u6784\u9176 I \u6291\u5236\u5242\u7684\u9776\u5411B7H3\u521b\u65b0 ADC\u5206\u5b50\u3002\u8de8\u819c\u7cd6\u86cb\u767d B7-H3 \u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f62\u6210\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u5b83\u5728\u5f88\u591a\u5b9e\u4f53\u7624\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u6709\u9650\uff0c\u4e0e\u75be\u75c5\u8fdb\u5c55\u548c\u9884\u540e\u6781\u5dee\u6709\u5173[1]\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cDB-1311\/BNT324\u5728\u5404\u79cd\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027[2]\u3002\u6b63\u5728\u8fdb\u884c\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff09\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cDB-1311\/BNT324\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002 2024 \u5e74\u00a06 \u6708\uff0cFDA\u6388\u4e88DB-1311\/ BNT324\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\/\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u30022024 […]<\/p>\n","protected":false},"author":0,"featured_media":5293,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-5292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u6620\u6069\u751f\u7269\u548cbiontech\u57282024-esmo-asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86b7h3-adc-db-1311-bnt324\u5728\u665a\u671f\u5b9e\u4f53\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"I\/IIa\u671f\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cDB-1311\/BNT324\u5728\u65e2\u5f80\u7ecf\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff08\u5982SCLC\u3001NSCLC\u548cCRPC\uff09\uff0c\u663e\u793a\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff1b\u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\uff0c\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0cuORR\u4e3a70.4%\uff1b\u5728CRPC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a28.0%\uff0c\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708, 6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u8ba1\u5212\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30DB-1311\/BNT324\u4e0eBNT327\/PM8002\uff08PD-L1\/VEGF-A\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u7684\u8054\u5408\u4f7f\u7528\uff1b\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597 SCLC \u6216 NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e 2025 \u5e74\u542f\u52a8\u3002 \u65b0\u6cfd\u897f\u5dde\u666e\u6797\u65af\u987f\u3001\u4e0a\u6d77\u548c\u82cf\u5dde2024\u5e7412\u67086\u65e5 \/\u7f8e\u901a\u793e\/ — Duality Biologics\uff08”\u6620\u6069\u751f\u7269”\uff09\u4eca\u65e5\u516c\u5e03\u4e86DB-1311\/BNT324\uff08\u9776\u5411B7H3\u7684\u521b\u65b0ADC\u5206\u5b50\uff09\u5168\u7403I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff0cCTR20232835\uff09\u7684\u9996\u6279\u6570\u636e\u3002\u8be5\u6570\u636e\u5728\u65b0\u52a0\u5761\u53ec\u5f00\u76842024\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e9a\u6d32\u5e74\u4f1a\uff08ESMO Asia\uff09\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u62ab\u9732\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002DB-1311\/BNT324 \u7531\u00a0\u6620\u6069\u751f\u7269\u548cBioNTech SE\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aBNTX\uff0c”BioNTech”\uff09\u5171\u540c\u5f00\u53d1\u3002 \u622a\u81f32024\u5e7409\u670827\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7ec4277\u4f8b\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u80bf\u7624\u7c7b\u578b\u5305\u62ec\u4f46\u4e0d\u9650\u4e8eSCLC\u3001NSCLC\u3001CRPC\u4ee5\u53caHNSCC\uff0c\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5171\u5165\u7ec4130\u4f8b\uff0c\u7ea6\u536047%\u3002ECOG\u8bc4\u5206\u4e3a1\u7684\u60a3\u8005\u7ea6\u536075%\uff0c\u63a5\u53d7\u8fc72\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u7ea6\u536061%\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u548c\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aDoR\u3001DCR\u3001PFS\u3001OS\u7b49\u3002\u7814\u7a76\u7ed3\u679c\u5177\u4f53\u5982\u4e0b\uff1a \u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff08n=238\uff09\uff0c\u603b\u4f53uORR\u4e3a32.4%\uff0cDCR\u4e3a82.4%\u3002SCLC\u60a3\u8005\u4e2d\uff08n=73\uff09\uff0cuORR\u4e3a56.2%\uff0cDCR\u4e3a89.0%\u3002\u7edd\u5927\u90e8\u5206SCLC\u60a3\u8005\u63a5\u53d7\u4e866 mg\/kg\u548c9 mg\/kg DB-1311\/BNT324\u6cbb\u7597\uff0c\u4e24\u7ec4\u4e4b\u95f4uORR\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u5206\u522b\u4e3a54.5%\u548c58.8%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a70.4%\u3002NSCLC\u60a3\u8005\u4e2d\uff0c\u5927\u90e8\u5206\u4e3a\u975e\u9cde\u764c\uff08n=41\uff09\uff0cuORR\u4e3a22.0%\uff1b\u9cde\u764c\u60a3\u8005\uff08n=25\uff09\uff0cuORR\u4e3a16.0%\u3002CRPC\u60a3\u8005\u4e2d\uff08n=32\uff09\uff0cDB-1311\/BNT324\u8868\u73b0\u51fa\u65e9\u671f\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u4e3a28.0%\uff0cDCR\u4e3a92.0%\uff0crPFS\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708\uff0c6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u5176\u4ed6\u7624\u79cd\u4e2d\uff0c\u5982\u5bab\u9888\u764c\uff08n=4\uff09\u3001\u809d\u7ec6\u80de\u764c\uff08n=12\uff09\u3001\u5934\u9888\u90e8\u9cde\u764c\uff08n=3\uff09\u548c\u9ed1\u8272\u7d20\u7624\uff08n=11\uff09\uff0cDB-1311\/BNT324\u540c\u6837\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u5206\u522b\u4e3a75.0%\u300125.0%\u3001100.0%\u548c36.4%\u3002DB-1311\/BNT324\u5728\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u80bf\u7624\u60a3\u8005\u4e2d\uff08n=277\uff09\u8868\u73b0\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002\u6700\u5e38\u89c1\u7684TRAE\u4e3a\u6076\u5fc3\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u98df\u6b32\u964d\u4f4e\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3002 \u6620\u6069\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6731\u5fe0\u8fdc\u535a\u58eb\u8868\u793a\uff1a”DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u4e0eBioNTech\u5171\u540c\u5f00\u53d1\u7684\u521b\u65b0ADC\u5206\u5b50\uff0c\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u9636\u6bb5\uff0c\u5176\u4e34\u5e8a\u6570\u636e\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u6620\u6069\u751f\u7269\u7684ADC\u6280\u672f\u5e73\u53f0\u53ef\u6301\u7eed\u5f00\u53d1\u51fa\u66f4\u591a\u65b0\u578bADC\u836f\u7269\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u4e30\u5bcc\u7684\u4e34\u5e8a\u89e3\u51b3\u65b9\u6848\uff0c\u8df5\u884c\u6620\u6069\u751f\u7269\u4e0d\u65ad\u63a2\u7d22\u521b\u65b0\u7597\u6cd5\u7684\u4fe1\u5ff5\uff0c\u5171\u540c\u63a8\u52a8\u5168\u7403ADC\u4ea7\u4e1a\u7684\u53d1\u5c55\uff0c\u60e0\u53ca\u75c5\u60a3\u3002” DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u548c\u00a0BioNTech\u5168\u7403\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u4e2d\u4e09\u4e2a\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u00a0ADC \u5019\u9009\u836f\u7269\u4e4b\u4e00\uff0c\u65e8\u5728\u63a8\u52a8\u8fd9\u4e9b\u65b0\u578b\u00a0ADC \u8fdb\u5165\u591a\u4e2a\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u764c\u75c7\u7684\u540e\u671f\u5f00\u53d1\u9636\u6bb5\u3002BNT327\/PM8002 \u662f\u65b0\u578b\u9776\u5411\u00a0PD-L1 \u548cVEGF-A \u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7531BioNTech\u548c\u666e\u7c73\u65af\u751f\u7269\u5171\u540c\u5f00\u53d1\u3002\u76ee\u524d\uff0c\u8bc4\u4f30\u00a0TROP2 ADC\uff08DB-1305\/BNT325\uff09\u548c\u00a0BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u53e6\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u00a0SCLC \u6216\u00a0NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e\u00a02025 \u5e74\u542f\u52a8\u3002 ### \u5173\u4e8eDB-1311\/BNT324 DB-1311\/BNT324\u662f\u57fa\u4e8e\u6620\u6069\u751f\u7269\u72ec\u521b\u7684DITAC\u6280\u672f\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3ADC\u4ea7\u54c1\u3002\u5b83\u5728\u4ee3\u8868\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u4e00\u7cfb\u5217\u80bf\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5e76\u4e14\u5728\u4e34\u5e8a\u524d\u5b89\u5168\u8bc4\u4f30\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u4e34\u5e8a\u524d\u6297\u80bf\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5c55\u793aDB-1311\/BNT324\u5728\u672a\u6765\u5e94\u7528\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u6cbb\u7597\u7a97\u53e3\uff0c\u5c06\u6709\u53ef\u80fd\u4e3a\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002 DB-1311\/BNT324 \u662f\u4e00\u79cd\u57fa\u4e8e\u62d3\u6251\u5f02\u6784\u9176 I \u6291\u5236\u5242\u7684\u9776\u5411B7H3\u521b\u65b0 ADC\u5206\u5b50\u3002\u8de8\u819c\u7cd6\u86cb\u767d B7-H3 \u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f62\u6210\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u5b83\u5728\u5f88\u591a\u5b9e\u4f53\u7624\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u6709\u9650\uff0c\u4e0e\u75be\u75c5\u8fdb\u5c55\u548c\u9884\u540e\u6781\u5dee\u6709\u5173[1]\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cDB-1311\/BNT324\u5728\u5404\u79cd\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027[2]\u3002\u6b63\u5728\u8fdb\u884c\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff09\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cDB-1311\/BNT324\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002 2024 \u5e74\u00a06 \u6708\uff0cFDA\u6388\u4e88DB-1311\/ BNT324\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\/\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u30022024 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/moneycompass.com.my\/cn\/\u6620\u6069\u751f\u7269\u548cbiontech\u57282024-esmo-asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86b7h3-adc-db-1311-bnt324\u5728\u665a\u671f\u5b9e\u4f53\/\" \/>\n<meta property=\"og:site_name\" content=\"Money Compass CN\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-06T03:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"144\" \/>\n\t<meta property=\"og:image:height\" content=\"44\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/\",\"name\":\"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e - Money Compass CN\",\"isPartOf\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg\",\"datePublished\":\"2024-12-06T03:00:00+00:00\",\"dateModified\":\"2024-12-06T03:00:00+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#primaryimage\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg\",\"contentUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg\",\"width\":144,\"height\":44},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/moneycompass.com.my\/cn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/\",\"name\":\"Money Compass CN\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e - Money Compass CN","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/moneycompass.com.my\/cn\/\u6620\u6069\u751f\u7269\u548cbiontech\u57282024-esmo-asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86b7h3-adc-db-1311-bnt324\u5728\u665a\u671f\u5b9e\u4f53\/","og_locale":"en_US","og_type":"article","og_title":"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e - Money Compass CN","og_description":"I\/IIa\u671f\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cDB-1311\/BNT324\u5728\u65e2\u5f80\u7ecf\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff08\u5982SCLC\u3001NSCLC\u548cCRPC\uff09\uff0c\u663e\u793a\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff1b\u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\uff0c\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0cuORR\u4e3a70.4%\uff1b\u5728CRPC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a28.0%\uff0c\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708, 6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u8ba1\u5212\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30DB-1311\/BNT324\u4e0eBNT327\/PM8002\uff08PD-L1\/VEGF-A\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u7684\u8054\u5408\u4f7f\u7528\uff1b\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597 SCLC \u6216 NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e 2025 \u5e74\u542f\u52a8\u3002 \u65b0\u6cfd\u897f\u5dde\u666e\u6797\u65af\u987f\u3001\u4e0a\u6d77\u548c\u82cf\u5dde2024\u5e7412\u67086\u65e5 \/\u7f8e\u901a\u793e\/ — Duality Biologics\uff08”\u6620\u6069\u751f\u7269”\uff09\u4eca\u65e5\u516c\u5e03\u4e86DB-1311\/BNT324\uff08\u9776\u5411B7H3\u7684\u521b\u65b0ADC\u5206\u5b50\uff09\u5168\u7403I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff0cCTR20232835\uff09\u7684\u9996\u6279\u6570\u636e\u3002\u8be5\u6570\u636e\u5728\u65b0\u52a0\u5761\u53ec\u5f00\u76842024\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e9a\u6d32\u5e74\u4f1a\uff08ESMO Asia\uff09\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u62ab\u9732\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cDB-1311\/BNT324\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002DB-1311\/BNT324 \u7531\u00a0\u6620\u6069\u751f\u7269\u548cBioNTech SE\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aBNTX\uff0c”BioNTech”\uff09\u5171\u540c\u5f00\u53d1\u3002 \u622a\u81f32024\u5e7409\u670827\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7ec4277\u4f8b\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u80bf\u7624\u7c7b\u578b\u5305\u62ec\u4f46\u4e0d\u9650\u4e8eSCLC\u3001NSCLC\u3001CRPC\u4ee5\u53caHNSCC\uff0c\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5171\u5165\u7ec4130\u4f8b\uff0c\u7ea6\u536047%\u3002ECOG\u8bc4\u5206\u4e3a1\u7684\u60a3\u8005\u7ea6\u536075%\uff0c\u63a5\u53d7\u8fc72\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u7ea6\u536061%\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u548c\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aDoR\u3001DCR\u3001PFS\u3001OS\u7b49\u3002\u7814\u7a76\u7ed3\u679c\u5177\u4f53\u5982\u4e0b\uff1a \u5728\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff08n=238\uff09\uff0c\u603b\u4f53uORR\u4e3a32.4%\uff0cDCR\u4e3a82.4%\u3002SCLC\u60a3\u8005\u4e2d\uff08n=73\uff09\uff0cuORR\u4e3a56.2%\uff0cDCR\u4e3a89.0%\u3002\u7edd\u5927\u90e8\u5206SCLC\u60a3\u8005\u63a5\u53d7\u4e866 mg\/kg\u548c9 mg\/kg DB-1311\/BNT324\u6cbb\u7597\uff0c\u4e24\u7ec4\u4e4b\u95f4uORR\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u5206\u522b\u4e3a54.5%\u548c58.8%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57289 mg\/kg\u5242\u91cf\u6c34\u5e73\u4e0b\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3001\u4f46\u672a\u63a5\u53d7\u8fc7\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\u6cbb\u7597\u7684SCLC\u60a3\u8005\u4e2d\uff0cuORR\u4e3a70.4%\u3002NSCLC\u60a3\u8005\u4e2d\uff0c\u5927\u90e8\u5206\u4e3a\u975e\u9cde\u764c\uff08n=41\uff09\uff0cuORR\u4e3a22.0%\uff1b\u9cde\u764c\u60a3\u8005\uff08n=25\uff09\uff0cuORR\u4e3a16.0%\u3002CRPC\u60a3\u8005\u4e2d\uff08n=32\uff09\uff0cDB-1311\/BNT324\u8868\u73b0\u51fa\u65e9\u671f\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u4e3a28.0%\uff0cDCR\u4e3a92.0%\uff0crPFS\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u4e2d\u4f4drPFS\u4e3a7.2\u4e2a\u6708\uff0c6\u4e2a\u6708rPFS\u7387\u4e3a94.7%\u3002\u5176\u4ed6\u7624\u79cd\u4e2d\uff0c\u5982\u5bab\u9888\u764c\uff08n=4\uff09\u3001\u809d\u7ec6\u80de\u764c\uff08n=12\uff09\u3001\u5934\u9888\u90e8\u9cde\u764c\uff08n=3\uff09\u548c\u9ed1\u8272\u7d20\u7624\uff08n=11\uff09\uff0cDB-1311\/BNT324\u540c\u6837\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0cuORR\u5206\u522b\u4e3a75.0%\u300125.0%\u3001100.0%\u548c36.4%\u3002DB-1311\/BNT324\u5728\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u80bf\u7624\u60a3\u8005\u4e2d\uff08n=277\uff09\u8868\u73b0\u51fa\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002\u6700\u5e38\u89c1\u7684TRAE\u4e3a\u6076\u5fc3\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u98df\u6b32\u964d\u4f4e\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3002 \u6620\u6069\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6731\u5fe0\u8fdc\u535a\u58eb\u8868\u793a\uff1a”DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u4e0eBioNTech\u5171\u540c\u5f00\u53d1\u7684\u521b\u65b0ADC\u5206\u5b50\uff0c\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u9636\u6bb5\uff0c\u5176\u4e34\u5e8a\u6570\u636e\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u6620\u6069\u751f\u7269\u7684ADC\u6280\u672f\u5e73\u53f0\u53ef\u6301\u7eed\u5f00\u53d1\u51fa\u66f4\u591a\u65b0\u578bADC\u836f\u7269\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u4e30\u5bcc\u7684\u4e34\u5e8a\u89e3\u51b3\u65b9\u6848\uff0c\u8df5\u884c\u6620\u6069\u751f\u7269\u4e0d\u65ad\u63a2\u7d22\u521b\u65b0\u7597\u6cd5\u7684\u4fe1\u5ff5\uff0c\u5171\u540c\u63a8\u52a8\u5168\u7403ADC\u4ea7\u4e1a\u7684\u53d1\u5c55\uff0c\u60e0\u53ca\u75c5\u60a3\u3002” DB-1311\/BNT324\u662f\u6620\u6069\u751f\u7269\u548c\u00a0BioNTech\u5168\u7403\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u4e2d\u4e09\u4e2a\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u00a0ADC \u5019\u9009\u836f\u7269\u4e4b\u4e00\uff0c\u65e8\u5728\u63a8\u52a8\u8fd9\u4e9b\u65b0\u578b\u00a0ADC \u8fdb\u5165\u591a\u4e2a\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u764c\u75c7\u7684\u540e\u671f\u5f00\u53d1\u9636\u6bb5\u3002BNT327\/PM8002 \u662f\u65b0\u578b\u9776\u5411\u00a0PD-L1 \u548cVEGF-A \u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7531BioNTech\u548c\u666e\u7c73\u65af\u751f\u7269\u5171\u540c\u5f00\u53d1\u3002\u76ee\u524d\uff0c\u8bc4\u4f30\u00a0TROP2 ADC\uff08DB-1305\/BNT325\uff09\u548c\u00a0BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u53e6\u4e00\u9879\u8bc4\u4f30DB-1311\/BNT324\u4e0e BNT327\/PM8002 \u8054\u5408\u6cbb\u7597\u00a0SCLC \u6216\u00a0NSCLC \u60a3\u8005\u7684I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4e8e\u00a02025 \u5e74\u542f\u52a8\u3002 ### \u5173\u4e8eDB-1311\/BNT324 DB-1311\/BNT324\u662f\u57fa\u4e8e\u6620\u6069\u751f\u7269\u72ec\u521b\u7684DITAC\u6280\u672f\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3ADC\u4ea7\u54c1\u3002\u5b83\u5728\u4ee3\u8868\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u4e00\u7cfb\u5217\u80bf\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5e76\u4e14\u5728\u4e34\u5e8a\u524d\u5b89\u5168\u8bc4\u4f30\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u4e34\u5e8a\u524d\u6297\u80bf\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5c55\u793aDB-1311\/BNT324\u5728\u672a\u6765\u5e94\u7528\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u6cbb\u7597\u7a97\u53e3\uff0c\u5c06\u6709\u53ef\u80fd\u4e3a\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002 DB-1311\/BNT324 \u662f\u4e00\u79cd\u57fa\u4e8e\u62d3\u6251\u5f02\u6784\u9176 I \u6291\u5236\u5242\u7684\u9776\u5411B7H3\u521b\u65b0 ADC\u5206\u5b50\u3002\u8de8\u819c\u7cd6\u86cb\u767d B7-H3 \u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f62\u6210\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u5b83\u5728\u5f88\u591a\u5b9e\u4f53\u7624\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u6709\u9650\uff0c\u4e0e\u75be\u75c5\u8fdb\u5c55\u548c\u9884\u540e\u6781\u5dee\u6709\u5173[1]\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cDB-1311\/BNT324\u5728\u5404\u79cd\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027[2]\u3002\u6b63\u5728\u8fdb\u884c\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05914116\uff09\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cDB-1311\/BNT324\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u7ba1\u7406\u7684\u5b89\u5168\u6027\u3002 2024 \u5e74\u00a06 \u6708\uff0cFDA\u6388\u4e88DB-1311\/ BNT324\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\/\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u30022024 […]","og_url":"https:\/\/moneycompass.com.my\/cn\/\u6620\u6069\u751f\u7269\u548cbiontech\u57282024-esmo-asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86b7h3-adc-db-1311-bnt324\u5728\u665a\u671f\u5b9e\u4f53\/","og_site_name":"Money Compass CN","article_published_time":"2024-12-06T03:00:00+00:00","og_image":[{"width":144,"height":44,"url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/","url":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/","name":"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e - Money Compass CN","isPartOf":{"@id":"https:\/\/moneycompass.com.my\/cn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#primaryimage"},"image":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#primaryimage"},"thumbnailUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg","datePublished":"2024-12-06T03:00:00+00:00","dateModified":"2024-12-06T03:00:00+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#primaryimage","url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg","contentUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2024\/12\/Duality_Biologics_logo_Logo-ieznzc.jpeg","width":144,"height":44},{"@type":"BreadcrumbList","@id":"https:\/\/moneycompass.com.my\/cn\/%e6%98%a0%e6%81%a9%e7%94%9f%e7%89%a9%e5%92%8cbiontech%e5%9c%a82024-esmo-asia%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e4%ba%86b7h3-adc-db-1311-bnt324%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/moneycompass.com.my\/cn\/"},{"@type":"ListItem","position":2,"name":"\u6620\u6069\u751f\u7269\u548cBioNTech\u57282024 ESMO Asia\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86B7H3 ADC (DB-1311\/BNT324)\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u79ef\u6781\u7684\u7814\u7a76\u6570\u636e"}]},{"@type":"WebSite","@id":"https:\/\/moneycompass.com.my\/cn\/#website","url":"https:\/\/moneycompass.com.my\/cn\/","name":"Money Compass CN","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/5292"}],"collection":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/comments?post=5292"}],"version-history":[{"count":0,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/5292\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media\/5293"}],"wp:attachment":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media?parent=5292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/categories?post=5292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/tags?post=5292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}