{"id":5473,"date":"2024-12-10T13:05:00","date_gmt":"2024-12-10T13:05:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e8%81%94%e5%90%88%e7%96%97%e6%b3%95%e5%9c%a8%e7%bb%b4%e5%a5%88%e5%85%8b\/"},"modified":"2024-12-10T13:05:00","modified_gmt":"2024-12-10T13:05:00","slug":"%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e8%81%94%e5%90%88%e7%96%97%e6%b3%95%e5%9c%a8%e7%bb%b4%e5%a5%88%e5%85%8b","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afbcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e8%81%94%e5%90%88%e7%96%97%e6%b3%95%e5%9c%a8%e7%bb%b4%e5%a5%88%e5%85%8b\/","title":{"rendered":"\u3010\u76f4\u51fbASH 2024\u3011\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242APG-2575\u8054\u5408\u7597\u6cd5\u5728\u7ef4\u5948\u514b\u62c9\u7ecf\u6cbb\u60a3\u8005\u4e2d\u7597\u6548\u826f\u597d"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c66\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86\u516c\u53f8\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u8981\u54c1\u79cdAPG-2575\uff08Lisaftoclax\uff09\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6570\u636e\u3002\u7f8e\u56fd\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u4e3a\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/891219\/Ascentage_Pharma_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684&#8221;\u4e2d\u56fd\u58f0\u97f3&#8221;\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u56db\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009ASH\u5e74\u4f1a\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e24\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002<\/p>\n<p>\u6b64\u6b21\u516c\u5e03\u7684\u7814\u7a76\u6570\u636e\u518d\u6b21\u663e\u793a\u4e86\u4e9a\u76db\u533b\u836f\u7684\u81ea\u7814Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u5728\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f3a\u52b2\u7684\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u6f5c\u529b\uff0c\u5c24\u5176\u663e\u793a\u4e86APG-2575\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u4e2d\u8fdb\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96be\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c2\u5bdf\u5230\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/p>\n<p>Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a&#8221;APG-2575\u518d\u4e00\u6b21\u5728\u591a\u4e2a\u4e9a\u7ec4\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u90fd\u5c55\u793a\u51fa\u975e\u5e38\u5f3a\u7684\u7597\u6548\uff0c\u5305\u62ec\u5728\u90a3\u4e9b\u65e2\u5f80\u7ecf\u8fc7\u7ef4\u5948\u514b\u62c9\u548cBTK\u6291\u5236\u5242\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u7ef4\u5948\u514b\u62c9\u4e0d\u8010\u53d7\u3001\u96be\u6cbb\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u8be5\u54c1\u79cd\u8fd8\u5177\u6709\u6781\u4f73\u7684\u8010\u53d7\u6027\uff0c\u5e76\u53ef\u4fbf\u6377\u5730\u901a\u8fc7\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u8fbe\u5230\u76ee\u6807\u5242\u91cf\u3002\u57fa\u4e8e\u8fd9\u4e9b\u826f\u597d\u7684\u65e9\u671f\u7814\u7a76\u7ed3\u679c\uff0cAPG-2575\u6709\u4e00\u9879\u5168\u7403\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76GLORA\u5df2\u7ecf\u542f\u52a8\uff0c\u76ee\u524d\u6b63\u79ef\u6781\u62db\u52df\u60a3\u8005\u4e2d\u3002&#8221;<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a&#8221;\u6b64\u6b21\u516c\u5e03\u7684\u6570\u636e\u518d\u4e00\u6b21\u5c55\u73b0\u4e86APG-2575\u5728CLL\/SLL\u9886\u57df\u5f3a\u52b2\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u76ee\u524d\u5728\u4e2d\u56fd\uff0cAPG-2575\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u5e76\u88ab\u63a8\u8350\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u4e3a\u5168\u7403\u7b2c\u4e8c\u4e2a\u4e0a\u5e02\u7684Bcl-2\u6291\u5236\u5242\uff1b\u800c\u5728\u5168\u7403\u8303\u56f4\u5185\uff0cAPG-2575\u6709\u4e00\u9879\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u540c\u610f\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u7814\u7a76\u6b63\u5728\u5f00\u5c55\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&#8217;\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdbAPG-2575\u5728\u5185\u7684\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002&#8221;<\/p>\n<p>\u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n<p>Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax<\/p>\n<p>Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5242\u91cf\u9012\u589e\u7ed9\u836f\u540e\u4e0e\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u5728\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u60a3\u8005\u00a0<\/p>\n<p>\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u62a5\u5c55\u793a<br \/>\u6458\u8981\u7f16\u53f7\uff1a4614<br \/>\u5206\u4f1a\u573a\uff1a642. 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TN\u536012.5%\uff0822\/176\uff09\uff1b\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u5e74\u9f8463\uff0834-80\uff09\u5c81\uff1b67%\u4e3a\u7537\u6027\uff1b25.6% 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mg\uff09\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\u7684\u60a3\u8005\u4ece\u7b2c1\u5468\u671f\u7684\u7b2c8\u5929\uff08C1D8\uff09\u5f00\u59cb\u52a0\u5165\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u8fdb\u5c55\u6216\u7b2c24\u4e2a\u5468\u671f\u5b9e\u73b0\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u6216\u8005\u89c2\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n<p>\u7597\u6548\u6570\u636e\uff1a<\/p>\n<p>\u572887\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0cORR\u4e3a98%\uff0c\u5728\u7f13\u89e3\u60a3\u8005\u4e2d\u7684DOR\uff08DOR; 95% CI, 31-NE\uff09\u548c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS; 95% CI, 34-NE\uff09\u5747\u672a\u8fbe\u5230\u3002<\/p>\n<p>\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7597\u7ec4\u4e2d\uff0c\u670914\u4f8b\u7ecf\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u540e\u590d\u53d1\/\u96be\u6cbb\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u6cbb\u7597\u5468\u671f\u4e3a16\uff083-25\uff09\u4e2a\uff0cORR\u4e3a86%\u3002\u4e2d\u4f4dPFS\u672a\u8fbe\u5230(11.3-NE)\uff0c12\u4e2a\u6708PFS\u7387\u4e3a84%\uff0c18\u4e2a\u6708PFS\u7387\u4e3a73%\u3002\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u6cbb\u7597\u7ec4\u4e2d\uff0c\u67099\u4f8b\u7ef4\u5948\u514b\u62c9\u96be\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u6cbb\u7597\u5468\u671f\u4e3a16\uff083-25\uff09\u4e2a\uff0cORR\u4e3a89%\u3002\u4e2d\u4f4dPFS\u672a\u8fbe\u5230(NE-NE)\uff0c12\u4e2a\u6708PFS\u7387\u4e3a89%\uff0c18\u4e2a\u6708PFS\u7387\u4e3a89%\u3002<\/p>\n<p>\u5b89\u5168\u6027\u6570\u636e\uff1a<\/p>\n<p>\u5404\u961f\u5217TEAEs\u7684\u53d1\u751f\u7387\u548c\u4e25\u91cd\u7a0b\u5ea6\u76f8\u4f3c\u3002\u6240\u6709\u961f\u5217\u4e2d\u5e38\u89c1\u7684\uff08\u226520%\uff09\u4efb\u610f\u7ea7\u522bTEAEs \u4e3a\u611f\u67d3\uff08107\u4f8b[61%]\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0867\u4f8b[38%]\uff09\u3001\u8d2b\u8840\uff0851\u4f8b[29%]\uff09\u3001\u8179\u6cfb\uff0851\u4f8b[29%]\uff09\u3001\u548c\u8840\u5c0f\u677f\u51cf\u5c11\uff0838\u4f8b[22%]\uff09\u3002 \u22653\u7ea7TEAEs\uff08\u226510%\uff09\u5728\u5355\u836f\u7ec4\u3001\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\u7ec4\u548c\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u7ec4\u4e2d\u5206\u522b\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c1115\u4f8b\uff0833%\uff09\u300111\u4f8b\uff0828%\uff09\u548c27\u4f8b\uff0830%\uff09\uff0c\u611f\u67d313\u4f8b\uff0828%\uff09\u30014\u4f8b\uff0810%\uff09\u548c14\u4f8b\uff0815%\uff09\uff0c\u8d2b\u88408\u4f8b\uff0817%\uff09\u30014\u4f8b\uff0810%\uff09\u548c11\u4f8b\uff0812%\uff09\u3002APG-2575\uff08Lisaftoclax\uff09\u5355\u72ec\u6216\u8054\u5408\u4f7f\u7528\uff0c\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4e34\u5e8a\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81(TLS)\u53d1\u751f\u7387\u4e3a1.1%\u3002APG-2575\uff08Lisaftoclax\uff09\u4e0e\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u5747\u672a\u89c2\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n<p>\u7ed3\u8bba\uff1a\u6b64\u6b21\u7814\u7a76\u6570\u636e\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u5bf9TN\u6216R\/R CLL\u60a3\u8005\u6709\u6548\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f422.3\u4e2a\u6708\u65f6\uff0cORR\u4e3a98%\uff0cDOR\u672a\u8fbe\u5230\u3002APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e0d\u8010\u53d7\u3001\u96be\u6cbb\u7684\u60a3\u8005\u3002\u8fd9\u9879\u968f\u8bbf\u65f6\u95f4\u8f83\u957f\u7684\u66f4\u65b0\u5206\u6790\u663e\u793a\uff0c\u5728\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09\u5355\u836f\u6cbb\u7597\/\u8054\u5408\u6cbb\u7597\u7684\u521d\u6cbb\u6216R\/R CLL\/SLL\u60a3\u8005\u4e2d\u672a\u89c2\u5bdf\u5230DDI\u6216\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u6211\u4eec\u4f1a\u7ee7\u7eed\u79ef\u7d2f\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u60a3\u8005\u6570\u636e\u6765\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u8fd9\u4e00\u9f13\u821e\u4eba\u5fc3\u7684\u7ed3\u679c\u3002APG-2575\uff08Lisaftoclax\uff09\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\u76ee\u524d\u6b63\u5728\u5165\u7ec4\u4e2d\u3002<\/p>\n<p>\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7efc\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u521b\u65b0\u836f\uff0c\u4ee5\u89e3\u51b3\u80bf\u7624\u7b49\u9886\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u5df2\u5efa\u7acb\u4e30\u5bcc\u7684\u521b\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 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Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer 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\u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given With Accelerated Ramp-up and Then Combined With Acalabrutinib or Rituximab in Patients (pts) With Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL), Including Those With Prior Exposure to Venetoclax Lisaftoclax\uff08APG-2575\uff09\u5728\u5feb\u901f\u5242\u91cf\u9012\u589e\u7ed9\u836f\u540e\u4e0e\u963f\u53ef\u66ff\u5c3c\u6216\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u5728\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u60a3\u8005\u00a0 [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":5474,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-5473","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u3010\u76f4\u51fbASH 2024\u3011\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242APG-2575\u8054\u5408\u7597\u6cd5\u5728\u7ef4\u5948\u514b\u62c9\u7ecf\u6cbb\u60a3\u8005\u4e2d\u7597\u6548\u826f\u597d - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u3010\u76f4\u51fbash-2024\u3011\u4e9a\u76db\u533b\u836fbcl-2\u6291\u5236\u5242apg-2575\u8054\u5408\u7597\u6cd5\u5728\u7ef4\u5948\u514b\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u51fbASH 2024\u3011\u4e9a\u76db\u533b\u836fBcl-2\u6291\u5236\u5242APG-2575\u8054\u5408\u7597\u6cd5\u5728\u7ef4\u5948\u514b\u62c9\u7ecf\u6cbb\u60a3\u8005\u4e2d\u7597\u6548\u826f\u597d - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c66\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86\u516c\u53f8\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u8981\u54c1\u79cdAPG-2575\uff08Lisaftoclax\uff09\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6700\u65b0\u6570\u636e\u3002\u7f8e\u56fd\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u4e3a\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684&#8221;\u4e2d\u56fd\u58f0\u97f3&#8221;\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u56db\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009ASH\u5e74\u4f1a\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e24\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002 \u6b64\u6b21\u516c\u5e03\u7684\u7814\u7a76\u6570\u636e\u518d\u6b21\u663e\u793a\u4e86\u4e9a\u76db\u533b\u836f\u7684\u81ea\u7814Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u5728\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u00a0CLL\/SLL\u60a3\u8005\u4e2d\u5f3a\u52b2\u7684\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u6f5c\u529b\uff0c\u5c24\u5176\u663e\u793a\u4e86APG-2575\u8054\u5408\u963f\u53ef\u66ff\u5c3c\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u60a3\u8005\u6709\u6548\uff0c\u5305\u62ec\u5728\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u4e2d\u8fdb\u5c55\u3001\u4e0d\u8010\u53d7\u53ca\u96be\u6cbb\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5747\u672a\u89c2\u5bdf\u5230\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u53ca\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002 Matthew S. 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