{"id":5475,"date":"2024-12-10T14:13:00","date_gmt":"2024-12-10T14:13:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91bcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e6%b2%bb%e7%96%97mds%e6%82%a3%e8%80%85%e6%95%b0%e6%8d%ae%e6%9b%b4%e6%96%b0%ef%bc%8c%e7%96%97%e6%95%88%e5%92%8c\/"},"modified":"2024-12-10T14:13:00","modified_gmt":"2024-12-10T14:13:00","slug":"%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91bcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e6%b2%bb%e7%96%97mds%e6%82%a3%e8%80%85%e6%95%b0%e6%8d%ae%e6%9b%b4%e6%96%b0%ef%bc%8c%e7%96%97%e6%95%88%e5%92%8c","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91bcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e6%b2%bb%e7%96%97mds%e6%82%a3%e8%80%85%e6%95%b0%e6%8d%ae%e6%9b%b4%e6%96%b0%ef%bc%8c%e7%96%97%e6%95%88%e5%92%8c\/","title":{"rendered":"\u3010\u76f4\u51fbASH 2024\u3011Bcl-2\u6291\u5236\u5242APG-2575\u6cbb\u7597MDS\u60a3\u8005\u6570\u636e\u66f4\u65b0\uff0c\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u5f02"},"content":{"rendered":"

\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2024\u5e7412\u670810\u65e5\u00a0<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c66\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u66f4\u65b0\u4e86\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u8054\u5408\u963f\u624e\u80de\u82f7\uff08AZA\uff09\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u968f\u8bbf\u6570\u636e\u3002<\/p>\n

\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684”\u4e2d\u56fd\u58f0\u97f3”\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u56db\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u00ae\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009ASH\u5e74\u4f1a\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e24\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002<\/p>\n

\u8fd9\u9879APG-2575\u8054\u5408AZA\u6cbb\u7597MDS\u7684\u7814\u7a76\u6570\u636e\u8fdb\u4e00\u6b65\u4f53\u73b0\u51fa\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u7684\u5f3a\u52b2\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u52bf\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u5728\u9ad8\u5371\u521d\u6cbb\uff08TN\uff09\u6216\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09MDS\u60a3\u8005\u4e2d\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe75%\uff0c\u4e14\u6ca1\u6709\u75c5\u4eba\u56e0\u6bd2\u6027\u4e0d\u8010\u53d7\u51fa\u7ec4\u3002<\/p>\n

\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u91d1\u6d01\u6559\u6388\u8868\u793a\uff1a”\u8f83\u9ad8\u5371MDS\u6cbb\u7597\u591a\u5e74\u6765\u7f3a\u4e4f\u91cd\u5927\u8fdb\u5c55\uff0c\u76ee\u524d\u53bb\u7532\u57fa\u5316\u836f\u7269\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\u7597\u6548\u4e0d\u591f\u6ee1\u610f\u3002\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\u8054\u5408AZA\u6cbb\u7597MDS\uff0c\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u597d\uff0c\u60a3\u8005\u80fd\u66f4\u597d\u8010\u53d7\uff0c\u53ef\u6301\u7eed\u6cbb\u7597\uff0c\u6709\u671b\u6539\u53d8MDS\u6807\u51c6\u6cbb\u7597\uff0c\u4f7f\u66f4\u591aMDS\u60a3\u8005\u53d7\u76ca\uff0c\u5ef6\u957f\u751f\u5b58\u3002”<\/p>\n

\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u62a5\u544a\u4eba\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7684\u738b\u534e\u950b\u535a\u58eb\u8868\u793a\uff1a”\u8f83\u9ad8\u5371MDS\u60a3\u8005\u666e\u904d\u9aa8\u9ad3\u529f\u80fd\u5dee\uff0c\u5bf9\u6cbb\u7597\u836f\u7269\u7684\u8010\u53d7\u6027\u5dee\u3002\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff0c\u6709\u6548\u6027\u9ad8\uff0c\u5b89\u5168\u6027\u597d\uff0c\u9aa8\u9ad3\u6291\u5236\u8f7b\uff0c\u5c24\u5176\u662f\u6cbb\u7597\u76f8\u5173\u611f\u67d3\u53d1\u751f\u7387\u4f4e\u3001\u7a0b\u5ea6\u8f83\u8f7b\uff0c\u65e9\u671f\u6b7b\u4ea1\u7387\u4e3a\u96f6\uff0c\u89e3\u51b3\u4e86\u8fd9\u7c7b\u96be\u6cbb\u60a3\u8005\u7684\u6700\u5927\u96be\u70b9\u95ee\u9898\uff0c\u662f\u8fd9\u79cd\u65b0\u578bBcl-2\u6291\u5236\u5242\u7684\u6700\u5927\u4eae\u70b9\u3002”<\/p>\n

\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”\u6b64\u6b21\u66f4\u65b0\u7684APG-2575\u8054\u5408AZA\u6cbb\u7597MDS\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u4ee4\u4eba\u6b23\u559c\uff0c\u518d\u6b21\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u7684\u5168\u7403\u2018Best-in-class’\u6f5c\u529b\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u54c1\u79cd\u8054\u5408AZA\u4e00\u7ebf\u6cbb\u7597MDS\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u4e2d\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6211\u4eec\u5f88\u9ad8\u5174APG-2575\u9488\u5bf9R\/R\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u56fd\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e\u8fd1\u65e5\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002”<\/p>\n

\u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n

Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor, in Combination with Azacitidine in Treatment of Patients with Myelodysplastic Syndrome (MDS) <\/p>\n

\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\uff08APG-2575\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09<\/p>\n

\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u62a5\u5c55\u793a<\/p>\n

\u6458\u8981\u7f16\u53f7\uff1a3202<\/p>\n

\u5206\u4f1a\u573a\uff1a637. \u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\u7814\u7a76\uff1a\u58c1\u62a5\u5c55\u793aII<\/p>\n

\u6838\u5fc3\u8981\u70b9\uff1a<\/p>\n

\u7814\u7a76\u80cc\u666f\uff1a\u53bb\u7532\u57fa\u5316\u836f\u7269\uff08HMA\uff09\u4ecd\u7136\u662f\u9ad8\u5371MDS\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u4f46\u4e34\u5e8a\u7597\u6548\u6b20\u4f73\u3002\u800cHMA\u6cbb\u7597\u5931\u8d25\/\u8010\u836f\u7684MDS\u60a3\u8005\uff0c\u9884\u540e\u5f88\u5dee\uff0c\u8fd9\u4e9b\u9ad8\u5371MDS\u60a3\u8005\u4e9f\u9700\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\u7814\u7a76\u4ecb\u7ecd\uff1a\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0c\u65b0\u578b\u7684Bcl-2\u6291\u5236\u5242APG-2575\uff08Lisaftoclax\uff09\u4e0eHMA\u8054\u5408\u53ef\u534f\u540c\u8bf1\u5bfcAML\u548cMDS\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u6b64\u6b21\u4f1a\u8bae\u62a5\u544a\u7684\u662f\u4e00\u9879Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u968f\u8bbf\u6570\u636e\uff0c\u91cd\u70b9\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6210\u4ebaMDS\u60a3\u8005\u7684\u7597\u6548\u3002<\/p>\n

\u5165\u7ec4\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a<\/p>\n

\u8be5\u7814\u7a76\u7eb3\u5165\u9ad8\u5371MDS\u60a3\u8005\uff08IPSS-R\u8bc4\u5206> 3.5\uff1b\u9aa8\u9ad3\u539f\u59cb\u7ec6\u80de>5%\uff09\uff0c\u5305\u62ec\u521d\u6cbb\uff08TN\uff09\u548cR\/R MDS\u60a3\u8005\u3002APG-2575\uff08Lisaftoclax\uff09\u4f7f\u7528\u6307\u5b9a\u5242\u91cf\uff08400mg, 600mg\u6216800mg\uff09\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7b2c1\u5929\u81f3\u7b2c14\u5929\u4f7f\u7528\uff1b\u5728\u7b2c1\u5929\u81f3\u7b2c7\u5929\u8054\u5408\u4f7f\u7528\u963f\u624e\u80de\u82f7(75mg \/m2\/\u5929)\uff0c\u6bcf28\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u5728\u7b2c\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u4e2d\uff0cAPG-2575\uff08Lisaftoclax\uff09\u91c7\u7528\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u4ee5\u9884\u9632\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81(TLS)\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30\u6b64\u8054\u5408\u7597\u6cd5\u6cbb\u7597MDS\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5e76\u786e\u5b9aAPG-2575\uff08Lisaftoclax\uff09\u7684\u63a8\u8350III\u671f\u5242\u91cf\u3002\u6839\u636e2006\u5e74\u56fd\u9645\u5de5\u4f5c\u7ec4\uff08IWG\uff09\u6807\u51c6\u8bc4\u4f30\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u9aa8\u9ad3\u5b8c\u5168\u7f13\u89e3\u7387\uff08mCR)\u3002\u622a\u81f32024\u5e747\u67081\u65e5\uff0c\u5171\u670949\u4f8b\u60a3\u8005\u5165\u7ec4\uff1a8\u4f8b\u4e3aR\/R MDS\uff08APG-2575 [Lisaftoclax] 600 mg [n = 5]\u548c800 mg [n = 3]\uff09\uff0c41\u4f8b\u4e3aTN MDS\uff08APG-2575 [Lisaftoclax] 400 mg [n = 16]\u3001600 mg [n = 23]\u548c800 mg [n = 2]\uff09\u3002\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u5e74\u9f84\u4e3a66\uff0822-83\uff09\u5c81\uff0c55.1%\u7684\u60a3\u8005\u4e3a\u7537\u6027\u3002IPSS-R\u98ce\u9669\u5206\u7ea7\u4e3a\u4e2d\u5371\uff0812\/49[24.5%]\uff09\u3001\u9ad8\u5371\uff0824\/49[49.0%]\uff09\u548c\u6781\u9ad8\u5371\uff0813\/49[26.5%]\uff09\u300239\u4f8b\u6709\u57fa\u56e0\u7a81\u53d8\u8c31\u6570\u636e\u7684\u60a3\u8005\u4e2d\uff0c9\u4f8b\uff0823.1%\uff09\u6709TP53\u7a81\u53d8\uff1b11\u4f8b\uff0828.2%\uff09\u6709TET2\u7a81\u53d8\uff1b10\u4f8b\uff0825.6%\uff09\u6709ASXL1\u7a81\u53d8\uff1b10\u4f8b\uff0825.6%\uff09\u6709RUNX1\u7a81\u53d8\u3002\u57fa\u7ebf\u65f6\uff0c70.8%\u7684\u60a3\u8005\u62a5\u544a\u4e86\u22653\u7ea7\u8d2b\u8840\uff1b54.2%\u62a5\u544a\u4e86\u22653\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff1b45.8%\u62a5\u544a\u4e86\u22653\u7ea7\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002<\/p>\n

\u7597\u6548\u6570\u636e\uff1a\u57288\u4f8bR\/R MDS\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u6cbb\u7597\u65f6\u95f4\uff08DOT\uff09\u4e3a3.2\uff081.2-9.4\uff09\u4e2a\u6708\u3002\u603b\u53cd\u5e94\u7387\uff08ORR = CR[12.5%] +mCR[62.5%]\uff09\u4e3a75.0%\uff0895% CI, 34.9-96.8\uff09\u3002\u572840\u4f8b\u53ef\u8bc4\u4f30\u7597\u6548\u7684TN MDS\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4dDOT\u4e3a4.5\uff080.5-12.1\uff09\u4e2a\u6708\uff1b\u6839\u636eIWG 2006\u6807\u51c6\uff0cORR\u4e3a77.5%\uff0895% CI, 61.5-89.2\uff09\uff0cCR\u7387\u4e3a25.0%\u3002\u6b64\u5916\uff0c23\u4f8b\u63a5\u53d7APG-2575\uff08Lisaftoclax\uff09600 mg\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7684TN MDS\u60a3\u8005\u4e2d\uff0cORR\u548cCR\u7387\u5206\u522b\u4e3a73.9%\u548c30.4%\uff1b\u7531\u4e8e\u8fd9\u4e9b\u60a3\u8005\u7684\u4e2d\u4f4d\u6cbb\u7597\u65f6\u95f4\u76f8\u5bf9\u8f83\u957f\uff086.01\u4e2a\u6708\uff09\uff0c\u6211\u4eec\u6839\u636eIWG 2023\u6807\u51c6\u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u5206\u6790\uff0c\u590d\u5408CR\u7387\uff08CR2023 = CR [52.2%] + CRL[17.4%]\uff09\u4e3a69.6%\uff0c\u4e2d\u4f4d\u8fbe\u5230CR\u65f6\u95f4\uff08\u8303\u56f4\uff09\u4e3a2.84\uff081.1-8.7\uff09\u4e2a\u6708\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5747\u672a\u8fbe\u5230\u3002<\/p>\n

\u5b89\u5168\u6027\u6570\u636e\uff1a<\/p>\n

46.9%\u7684\u60a3\u8005\u62a5\u544a\u22653\u7ea7\u611f\u67d3\uff0c\u5176\u4e2d26.5%\u4e0e\u6cbb\u7597\u76f8\u5173\u300211\u4f8b\uff0822.4%\uff09\u60a3\u8005\u53d1\u751f\u4e86\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u7684\u5468\u671f\u95f4\u6cbb\u7597\u5ef6\u8fdf\uff0c\u4e2d\u4f4d\u5ef6\u8fdf\u65f6\u95f4(\u8303\u56f4)\u4e3a12\uff081-63\uff09\u5929\u3002\u5171\u670995.9%\u7684\u60a3\u8005\u62a5\u544a\u4e86\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u5176\u4e2d87.8%\u4e3a\u22653\u7ea7AEs\uff0c28.6%\u4e3a\u4e25\u91cdAEs\u3002\u5e38\u89c1\u7684\u22653\u7ea7\u8840\u6db2\u5b66TRAEs\u5305\u62ec\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0871.4%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0865.3%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff0865.3%\uff09\u3001\u8d2b\u8840\uff0820.4%\uff09\u548c\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0812.2%\uff09\u300260\u5929\u6b7b\u4ea1\u7387\u548cTLS\u53d1\u751f\u7387\u5747\u4e3a0\u3002<\/p>\n

\u7ed3\u8bba\uff1a\u4ee5\u4e0a\u4e34\u5e8a\u6570\u636e\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u9ad8\u5371TN\u6216R\/R MDS\u60a3\u8005\u6cbb\u7597\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u8be5\u8054\u5408\u6cbb\u7597\u5448\u73b0\u826f\u597d\u7684\u6709\u6548\u6027\u548c\u8010\u53d7\u6027\uff0c60\u5929\u6b7b\u4ea1\u7387\u4e3a0\uff0c\u9700\u8981APG-2575\uff08Lisaftoclax\uff09\u51cf\u91cf\u7684\u60a3\u8005\u5c11\uff0c\u611f\u67d3\u7387\u4f4e\uff0c\u652f\u6301\u8be5\u8054\u5408\u6cbb\u7597\u5728\u9ad8\u98ce\u9669MDS\u60a3\u8005\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5f00\u53d1\u3002<\/p>\n

\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/p>\n

\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7efc\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u521b\u65b0\u836f\uff0c\u4ee5\u89e3\u51b3\u80bf\u7624\u7b49\u9886\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u5df2\u5efa\u7acb\u4e30\u5bcc\u7684\u521b\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5540\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u5305\u62ec13\u9879\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u8fdb\u884c\u4e2d\/\u62df\u542f\u52a8\uff09\u3002<\/p>\n

\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u8010\u7acb\u514b\u00ae\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u88ab\u6210\u529f\u7eb3\u5165\u300a\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u300b\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9716\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0e\u6b66\u7530\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u3001\u4fe1\u8fbe\u7b49\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b66\u7b49\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u5df2\u6784\u5efa\u5728\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u9886\u57df\u7ecf\u9a8c\u4e30\u5bcc\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u4e0e\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c”\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42”\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/p>\n

\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n

SOURCE \u4e9a\u76db\u533b\u836f<\/p>","protected":false},"excerpt":{"rendered":"

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\u8fd9\u9879APG-2575\u8054\u5408AZA\u6cbb\u7597MDS\u7684\u7814\u7a76\u6570\u636e\u8fdb\u4e00\u6b65\u4f53\u73b0\u51fa\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u7684\u5f3a\u52b2\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u52bf\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u5728\u9ad8\u5371\u521d\u6cbb\uff08TN\uff09\u6216\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09MDS\u60a3\u8005\u4e2d\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe75%\uff0c\u4e14\u6ca1\u6709\u75c5\u4eba\u56e0\u6bd2\u6027\u4e0d\u8010\u53d7\u51fa\u7ec4\u3002 \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u91d1\u6d01\u6559\u6388\u8868\u793a\uff1a”\u8f83\u9ad8\u5371MDS\u6cbb\u7597\u591a\u5e74\u6765\u7f3a\u4e4f\u91cd\u5927\u8fdb\u5c55\uff0c\u76ee\u524d\u53bb\u7532\u57fa\u5316\u836f\u7269\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\u7597\u6548\u4e0d\u591f\u6ee1\u610f\u3002\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\u8054\u5408AZA\u6cbb\u7597MDS\uff0c\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u597d\uff0c\u60a3\u8005\u80fd\u66f4\u597d\u8010\u53d7\uff0c\u53ef\u6301\u7eed\u6cbb\u7597\uff0c\u6709\u671b\u6539\u53d8MDS\u6807\u51c6\u6cbb\u7597\uff0c\u4f7f\u66f4\u591aMDS\u60a3\u8005\u53d7\u76ca\uff0c\u5ef6\u957f\u751f\u5b58\u3002” \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u62a5\u544a\u4eba\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7684\u738b\u534e\u950b\u535a\u58eb\u8868\u793a\uff1a”\u8f83\u9ad8\u5371MDS\u60a3\u8005\u666e\u904d\u9aa8\u9ad3\u529f\u80fd\u5dee\uff0c\u5bf9\u6cbb\u7597\u836f\u7269\u7684\u8010\u53d7\u6027\u5dee\u3002\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff0c\u6709\u6548\u6027\u9ad8\uff0c\u5b89\u5168\u6027\u597d\uff0c\u9aa8\u9ad3\u6291\u5236\u8f7b\uff0c\u5c24\u5176\u662f\u6cbb\u7597\u76f8\u5173\u611f\u67d3\u53d1\u751f\u7387\u4f4e\u3001\u7a0b\u5ea6\u8f83\u8f7b\uff0c\u65e9\u671f\u6b7b\u4ea1\u7387\u4e3a\u96f6\uff0c\u89e3\u51b3\u4e86\u8fd9\u7c7b\u96be\u6cbb\u60a3\u8005\u7684\u6700\u5927\u96be\u70b9\u95ee\u9898\uff0c\u662f\u8fd9\u79cd\u65b0\u578bBcl-2\u6291\u5236\u5242\u7684\u6700\u5927\u4eae\u70b9\u3002” \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”\u6b64\u6b21\u66f4\u65b0\u7684APG-2575\u8054\u5408AZA\u6cbb\u7597MDS\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u4ee4\u4eba\u6b23\u559c\uff0c\u518d\u6b21\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u7684\u5168\u7403\u2018Best-in-class’\u6f5c\u529b\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u54c1\u79cd\u8054\u5408AZA\u4e00\u7ebf\u6cbb\u7597MDS\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u4e2d\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6211\u4eec\u5f88\u9ad8\u5174APG-2575\u9488\u5bf9R\/R\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u56fd\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e\u8fd1\u65e5\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002” \u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor, in Combination with Azacitidine in Treatment of Patients with Myelodysplastic Syndrome (MDS) \u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\uff08APG-2575\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u62a5\u5c55\u793a \u6458\u8981\u7f16\u53f7\uff1a3202 \u5206\u4f1a\u573a\uff1a637. \u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\u7814\u7a76\uff1a\u58c1\u62a5\u5c55\u793aII \u6838\u5fc3\u8981\u70b9\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u53bb\u7532\u57fa\u5316\u836f\u7269\uff08HMA\uff09\u4ecd\u7136\u662f\u9ad8\u5371MDS\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u4f46\u4e34\u5e8a\u7597\u6548\u6b20\u4f73\u3002\u800cHMA\u6cbb\u7597\u5931\u8d25\/\u8010\u836f\u7684MDS\u60a3\u8005\uff0c\u9884\u540e\u5f88\u5dee\uff0c\u8fd9\u4e9b\u9ad8\u5371MDS\u60a3\u8005\u4e9f\u9700\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002 \u7814\u7a76\u4ecb\u7ecd\uff1a\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0c\u65b0\u578b\u7684Bcl-2\u6291\u5236\u5242APG-2575\uff08Lisaftoclax\uff09\u4e0eHMA\u8054\u5408\u53ef\u534f\u540c\u8bf1\u5bfcAML\u548cMDS\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u6b64\u6b21\u4f1a\u8bae\u62a5\u544a\u7684\u662f\u4e00\u9879Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u968f\u8bbf\u6570\u636e\uff0c\u91cd\u70b9\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6210\u4ebaMDS\u60a3\u8005\u7684\u7597\u6548\u3002 \u5165\u7ec4\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u8be5\u7814\u7a76\u7eb3\u5165\u9ad8\u5371MDS\u60a3\u8005\uff08IPSS-R\u8bc4\u5206> 3.5\uff1b\u9aa8\u9ad3\u539f\u59cb\u7ec6\u80de>5%\uff09\uff0c\u5305\u62ec\u521d\u6cbb\uff08TN\uff09\u548cR\/R MDS\u60a3\u8005\u3002APG-2575\uff08Lisaftoclax\uff09\u4f7f\u7528\u6307\u5b9a\u5242\u91cf\uff08400mg, 600mg\u6216800mg\uff09\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7b2c1\u5929\u81f3\u7b2c14\u5929\u4f7f\u7528\uff1b\u5728\u7b2c1\u5929\u81f3\u7b2c7\u5929\u8054\u5408\u4f7f\u7528\u963f\u624e\u80de\u82f7(75mg \/m2\/\u5929)\uff0c\u6bcf28\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u5728\u7b2c\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u4e2d\uff0cAPG-2575\uff08Lisaftoclax\uff09\u91c7\u7528\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u4ee5\u9884\u9632\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81(TLS)\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30\u6b64\u8054\u5408\u7597\u6cd5\u6cbb\u7597MDS\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5e76\u786e\u5b9aAPG-2575\uff08Lisaftoclax\uff09\u7684\u63a8\u8350III\u671f\u5242\u91cf\u3002\u6839\u636e2006\u5e74\u56fd\u9645\u5de5\u4f5c\u7ec4\uff08IWG\uff09\u6807\u51c6\u8bc4\u4f30\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u9aa8\u9ad3\u5b8c\u5168\u7f13\u89e3\u7387\uff08mCR)\u3002\u622a\u81f32024\u5e747\u67081\u65e5\uff0c\u5171\u670949\u4f8b\u60a3\u8005\u5165\u7ec4\uff1a8\u4f8b\u4e3aR\/R MDS\uff08APG-2575 [Lisaftoclax] 600 mg [n = 5]\u548c800 mg [n […]<\/p>\n","protected":false},"author":0,"featured_media":5476,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-5475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u3010\u76f4\u51fbASH 2024\u3011Bcl-2\u6291\u5236\u5242APG-2575\u6cbb\u7597MDS\u60a3\u8005\u6570\u636e\u66f4\u65b0\uff0c\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u5f02 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u3010\u76f4\u51fbash-2024\u3011bcl-2\u6291\u5236\u5242apg-2575\u6cbb\u7597mds\u60a3\u8005\u6570\u636e\u66f4\u65b0\uff0c\u7597\u6548\u548c\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u51fbASH 2024\u3011Bcl-2\u6291\u5236\u5242APG-2575\u6cbb\u7597MDS\u60a3\u8005\u6570\u636e\u66f4\u65b0\uff0c\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u5f02 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2024\u5e7412\u670810\u65e5\u00a0 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c66\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u66f4\u65b0\u4e86\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u8054\u5408\u963f\u624e\u80de\u82f7\uff08AZA\uff09\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u968f\u8bbf\u6570\u636e\u3002 ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684”\u4e2d\u56fd\u58f0\u97f3”\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u56db\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u00ae\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009ASH\u5e74\u4f1a\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e24\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002 \u8fd9\u9879APG-2575\u8054\u5408AZA\u6cbb\u7597MDS\u7684\u7814\u7a76\u6570\u636e\u8fdb\u4e00\u6b65\u4f53\u73b0\u51fa\u8be5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u7684\u5f3a\u52b2\u7597\u6548\u548c\u5b89\u5168\u6027\u4f18\u52bf\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u5728\u9ad8\u5371\u521d\u6cbb\uff08TN\uff09\u6216\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09MDS\u60a3\u8005\u4e2d\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe75%\uff0c\u4e14\u6ca1\u6709\u75c5\u4eba\u56e0\u6bd2\u6027\u4e0d\u8010\u53d7\u51fa\u7ec4\u3002 \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u91d1\u6d01\u6559\u6388\u8868\u793a\uff1a”\u8f83\u9ad8\u5371MDS\u6cbb\u7597\u591a\u5e74\u6765\u7f3a\u4e4f\u91cd\u5927\u8fdb\u5c55\uff0c\u76ee\u524d\u53bb\u7532\u57fa\u5316\u836f\u7269\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\u7597\u6548\u4e0d\u591f\u6ee1\u610f\u3002\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\u8054\u5408AZA\u6cbb\u7597MDS\uff0c\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u597d\uff0c\u60a3\u8005\u80fd\u66f4\u597d\u8010\u53d7\uff0c\u53ef\u6301\u7eed\u6cbb\u7597\uff0c\u6709\u671b\u6539\u53d8MDS\u6807\u51c6\u6cbb\u7597\uff0c\u4f7f\u66f4\u591aMDS\u60a3\u8005\u53d7\u76ca\uff0c\u5ef6\u957f\u751f\u5b58\u3002” \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u62a5\u544a\u4eba\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7684\u738b\u534e\u950b\u535a\u58eb\u8868\u793a\uff1a”\u8f83\u9ad8\u5371MDS\u60a3\u8005\u666e\u904d\u9aa8\u9ad3\u529f\u80fd\u5dee\uff0c\u5bf9\u6cbb\u7597\u836f\u7269\u7684\u8010\u53d7\u6027\u5dee\u3002\u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff0c\u6709\u6548\u6027\u9ad8\uff0c\u5b89\u5168\u6027\u597d\uff0c\u9aa8\u9ad3\u6291\u5236\u8f7b\uff0c\u5c24\u5176\u662f\u6cbb\u7597\u76f8\u5173\u611f\u67d3\u53d1\u751f\u7387\u4f4e\u3001\u7a0b\u5ea6\u8f83\u8f7b\uff0c\u65e9\u671f\u6b7b\u4ea1\u7387\u4e3a\u96f6\uff0c\u89e3\u51b3\u4e86\u8fd9\u7c7b\u96be\u6cbb\u60a3\u8005\u7684\u6700\u5927\u96be\u70b9\u95ee\u9898\uff0c\u662f\u8fd9\u79cd\u65b0\u578bBcl-2\u6291\u5236\u5242\u7684\u6700\u5927\u4eae\u70b9\u3002” \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”\u6b64\u6b21\u66f4\u65b0\u7684APG-2575\u8054\u5408AZA\u6cbb\u7597MDS\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u4ee4\u4eba\u6b23\u559c\uff0c\u518d\u6b21\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u7684\u5168\u7403\u2018Best-in-class’\u6f5c\u529b\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u54c1\u79cd\u8054\u5408AZA\u4e00\u7ebf\u6cbb\u7597MDS\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u6b63\u5728\u5f00\u5c55\u4e2d\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6211\u4eec\u5f88\u9ad8\u5174APG-2575\u9488\u5bf9R\/R\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u56fd\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e\u8fd1\u65e5\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002” \u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor, in Combination with Azacitidine in Treatment of Patients with Myelodysplastic Syndrome (MDS) \u65b0\u578bBcl-2\u6291\u5236\u5242Lisaftoclax\uff08APG-2575\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u62a5\u5c55\u793a \u6458\u8981\u7f16\u53f7\uff1a3202 \u5206\u4f1a\u573a\uff1a637. \u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\u7814\u7a76\uff1a\u58c1\u62a5\u5c55\u793aII \u6838\u5fc3\u8981\u70b9\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u53bb\u7532\u57fa\u5316\u836f\u7269\uff08HMA\uff09\u4ecd\u7136\u662f\u9ad8\u5371MDS\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u4f46\u4e34\u5e8a\u7597\u6548\u6b20\u4f73\u3002\u800cHMA\u6cbb\u7597\u5931\u8d25\/\u8010\u836f\u7684MDS\u60a3\u8005\uff0c\u9884\u540e\u5f88\u5dee\uff0c\u8fd9\u4e9b\u9ad8\u5371MDS\u60a3\u8005\u4e9f\u9700\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002 \u7814\u7a76\u4ecb\u7ecd\uff1a\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0c\u65b0\u578b\u7684Bcl-2\u6291\u5236\u5242APG-2575\uff08Lisaftoclax\uff09\u4e0eHMA\u8054\u5408\u53ef\u534f\u540c\u8bf1\u5bfcAML\u548cMDS\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u6b64\u6b21\u4f1a\u8bae\u62a5\u544a\u7684\u662f\u4e00\u9879Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u968f\u8bbf\u6570\u636e\uff0c\u91cd\u70b9\u8bc4\u4f30APG-2575\uff08Lisaftoclax\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u6210\u4ebaMDS\u60a3\u8005\u7684\u7597\u6548\u3002 \u5165\u7ec4\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u8be5\u7814\u7a76\u7eb3\u5165\u9ad8\u5371MDS\u60a3\u8005\uff08IPSS-R\u8bc4\u5206> 3.5\uff1b\u9aa8\u9ad3\u539f\u59cb\u7ec6\u80de>5%\uff09\uff0c\u5305\u62ec\u521d\u6cbb\uff08TN\uff09\u548cR\/R MDS\u60a3\u8005\u3002APG-2575\uff08Lisaftoclax\uff09\u4f7f\u7528\u6307\u5b9a\u5242\u91cf\uff08400mg, 600mg\u6216800mg\uff09\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7b2c1\u5929\u81f3\u7b2c14\u5929\u4f7f\u7528\uff1b\u5728\u7b2c1\u5929\u81f3\u7b2c7\u5929\u8054\u5408\u4f7f\u7528\u963f\u624e\u80de\u82f7(75mg \/m2\/\u5929)\uff0c\u6bcf28\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u5728\u7b2c\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u4e2d\uff0cAPG-2575\uff08Lisaftoclax\uff09\u91c7\u7528\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u4ee5\u9884\u9632\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81(TLS)\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30\u6b64\u8054\u5408\u7597\u6cd5\u6cbb\u7597MDS\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5e76\u786e\u5b9aAPG-2575\uff08Lisaftoclax\uff09\u7684\u63a8\u8350III\u671f\u5242\u91cf\u3002\u6839\u636e2006\u5e74\u56fd\u9645\u5de5\u4f5c\u7ec4\uff08IWG\uff09\u6807\u51c6\u8bc4\u4f30\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u9aa8\u9ad3\u5b8c\u5168\u7f13\u89e3\u7387\uff08mCR)\u3002\u622a\u81f32024\u5e747\u67081\u65e5\uff0c\u5171\u670949\u4f8b\u60a3\u8005\u5165\u7ec4\uff1a8\u4f8b\u4e3aR\/R MDS\uff08APG-2575 [Lisaftoclax] 600 mg [n = 5]\u548c800 mg [n […]\" \/>\n<meta property=\"og:url\" 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