{"id":5477,"date":"2024-12-10T13:49:00","date_gmt":"2024-12-10T13:49:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e8%80%90%e7%ab%8b%e5%85%8b%e6%b5%b7%e5%a4%96%e7%a0%94%e7%a9%b61-5%e5%b9%b4%e9%9a%8f%e8%ae%bf%e6%95%b0%e6%8d%ae%e5%85%ac\/"},"modified":"2024-12-10T13:49:00","modified_gmt":"2024-12-10T13:49:00","slug":"%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e8%80%90%e7%ab%8b%e5%85%8b%e6%b5%b7%e5%a4%96%e7%a0%94%e7%a9%b61-5%e5%b9%b4%e9%9a%8f%e8%ae%bf%e6%95%b0%e6%8d%ae%e5%85%ac","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e8%80%90%e7%ab%8b%e5%85%8b%e6%b5%b7%e5%a4%96%e7%a0%94%e7%a9%b61-5%e5%b9%b4%e9%9a%8f%e8%ae%bf%e6%95%b0%e6%8d%ae%e5%85%ac\/","title":{"rendered":"\u3010\u76f4\u51fbASH 2024\u3011\u4e9a\u76db\u533b\u836f\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a761.5\u5e74\u968f\u8bbf\u6570\u636e\u516c\u5e03\uff0c\u518d\u8bc1\u53ef\u514b\u670d\u60a3\u8005\u5bf9ponatinib\u6216asciminib\u7684\u8010\u836f\/\u4e0d\u8010\u53d7"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c66\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u66f4\u65b0\u4e86\u516c\u53f8\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u7814\u53d1\u4ee3\u53f7\uff1aHQP1351\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u6cbb\u7597\u53cd\u590d\u7ecf\u6cbb\u7684\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u60a3\u8005\u7684\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6570\u636e\u3002\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08The <span class=\"xn-org\">University of Texas<\/span> MD Anderson Cancer Center\uff09\u767d\u8840\u75c5\u79d1\u7684Hagop Kantarjian\u6559\u6388\u548cElias Jabbour \u6559\u6388\u4e3a\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/891219\/Ascentage_Pharma_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684&#8221;\u4e2d\u56fd\u58f0\u97f3&#8221;\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u56db\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009ASH\u5e74\u4f1a\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e24\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e5f\u662f\u8010\u7acb\u514b\u7684\u7814\u53d1\u6570\u636e\u8fde\u7eed\u7b2c\u4e03\u5e74\u5165\u9009ASH\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\u3002<\/p>\n<p>\u7ee72022\u5e74\u5728ASH\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u30012023\u5e74\u5728ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u8be5\u54c1\u79cd\u5728\u66f4\u5927\u6837\u672c\u91cf\u7684\u60a3\u8005\u4e2d\u7684\u8fdb\u5c55\u540e\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u5c55\u793a\u4e86\u8010\u7acb\u514b\u6cbb\u7597\u53cd\u590d\u7ecf\u6cbb\u7684CML-CP\u60a3\u8005\u76841.5\u5e74\u968f\u8bbf\u6700\u65b0\u6570\u636e\u3002\u6b64\u6b21\u7814\u7a76\u7ed3\u679c\u518d\u6b21\u8868\u660e\uff0c\u8010\u7acb\u514b\u5728\u524d\u671f\u7ecf\u8fc7\u6df1\u5ea6\u6cbb\u7597\u7684CML-CP\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u663e\u8457\u3001\u6301\u4e45\u800c\u7a33\u5b9a\u7684\u6297\u767d\u8840\u75c5\u6d3b\u6027\uff0c\u5e76\u53ef\u514b\u670d\u60a3\u8005\u5bf9\u7b2c\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09Ponatinib\u6216\u53d8\u6784\u6291\u5236\u5242Asciminib\u7684\u8010\u836f\/\u4e0d\u8010\u53d7\uff0c\u540c\u65f6\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002<\/p>\n<p>\u8010\u7acb\u514b\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u8be5\u54c1\u79cd\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55TKI\u8010\u836f\uff0c\u5e76\u4f34\u6709T315I\u7a81\u53d8\u7684CML-CP\u6216CML-\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u5bf9\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u836f\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u4eca\u5e741\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u540c\u610f\u8010\u7acb\u514b\u5f00\u5c55\u4e00\u9879\u5168\u7403\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002<\/p>\n<p>Elias Jabbour\u6559\u6388\u8868\u793a\uff1a\u00a0&#8220;\u5965\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u6b3e\u6781\u5177\u6f5c\u529b\u7684\u65b0\u4e00\u4ee3TKI\u836f\u7269\u3002\u73b0\u6709\u6570\u636e\u663e\u793a\uff0c\u8be5\u836f\u7269\u5728\u5bf9\u4e24\u79cd\u6216\u66f4\u591aTKI\u8010\u836f\/\u4e0d\u8010\u53d7\u7684CP-CML\u60a3\u8005\u4e2d\u5177\u6709\u7597\u6548\u3002\u6b64\u5916\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u5728Ponatinib\u6216Asciminib\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u663e\u793a\u7684\u9ad8\u7f13\u89e3\u7387\u4ee4\u4eba\u632f\u594b\u3002\u6211\u4eec\u6b63\u5728\u4e3a\u4e00\u9879\u8bc4\u4f30\u8be5\u65b0\u578b\u836f\u7269\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u7814\u7a76\u62db\u52df\u60a3\u8005\u3002&#8221;<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a&#8221;\u6b64\u6b21\u5728ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6570\u636e\u8fdb\u4e00\u6b65\u8868\u660e\u8be5\u54c1\u79cd\u5728\u8010\u836fCML\u3001\u5305\u62ec\u7ecfponatinib\u548casciminib\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u5de8\u5927\u6cbb\u7597\u6f5c\u529b\uff0c\u4e5f\u518d\u6b21\u8868\u660e\u8be5\u54c1\u79cd\u6709\u671b\u586b\u8865\u5168\u7403CML\u6cbb\u7597\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u5df2\u6709\u4e00\u9879\u7ecfFDA\u540c\u610f\u7684\u5168\u7403\u6ce8\u518cIII\u671f\u7814\u7a76\u6b63\u5728\u5f00\u5c55\u3002\u76f8\u4fe1\u5728\u4e0d\u8fdc\u7684\u672a\u6765\uff0c\u6211\u4eec\u80fd\u591f\u5c06\u8fd9\u4e00\u521b\u65b0\u836f\u7269\u5c3d\u5feb\u5e26\u7ed9\u5168\u7403\u4e9f\u9700\u65b0\u578b\u7597\u6cd5\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&#8217;\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdb\u8010\u7acb\u514b\u5728\u5185\u7684\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002&#8221;<\/p>\n<p>\u6b64\u9879\u7814\u7a76\u57282024 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\u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Olverembatinib (HQP1351) Overcomes Resistance\/Intolerance to Asciminib and Ponatinib in Patients (pts) with Heavily Pretreated Chronic-Phase Chronic Myeloid Leukemia (CP CML): A 1.5-Year Follow-up Update with Comprehensive Exposure-Response (E-R) Analyses \u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u53ef\u514b\u670d\u7ecf\u6df1\u5ea6\u6cbb\u7597\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CP CML\uff09\u60a3\u8005\u5bf9Asciminib\u548cPonatinib\u7684\u8010\u836f\/\u4e0d\u8010\u53d7\uff1a\u6765\u81ea1.5\u5e74\u968f\u8bbf\u7684\u6700\u65b0\u6570\u636e\u53ca\u7efc\u5408\u66b4\u9732-\u53cd\u5e94\uff08E-R\uff09\u5206\u6790 [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":5478,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-5477","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u3010\u76f4\u51fbASH 2024\u3011\u4e9a\u76db\u533b\u836f\u8010\u7acb\u514b\u6d77\u5916\u7814\u7a761.5\u5e74\u968f\u8bbf\u6570\u636e\u516c\u5e03\uff0c\u518d\u8bc1\u53ef\u514b\u670d\u60a3\u8005\u5bf9ponatinib\u6216asciminib\u7684\u8010\u836f\/\u4e0d\u8010\u53d7 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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