{"id":5487,"date":"2024-12-10T14:14:00","date_gmt":"2024-12-10T14:14:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e6%96%a9%e8%8e%b7%e6%91%98%e8%a6%81%e6%88%90%e5%b0%b1%e5%a5%96%ef%bc%81%e8%80%90%e7%ab%8b%e5%85%8b%e8%81%94%e5%90%88bcl-2%e6%8a%91%e5%88%b6%e5%89%82a\/"},"modified":"2024-12-10T14:14:00","modified_gmt":"2024-12-10T14:14:00","slug":"%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e6%96%a9%e8%8e%b7%e6%91%98%e8%a6%81%e6%88%90%e5%b0%b1%e5%a5%96%ef%bc%81%e8%80%90%e7%ab%8b%e5%85%8b%e8%81%94%e5%90%88bcl-2%e6%8a%91%e5%88%b6%e5%89%82a","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e3%80%90%e7%9b%b4%e5%87%bbash-2024%e3%80%91%e6%96%a9%e8%8e%b7%e6%91%98%e8%a6%81%e6%88%90%e5%b0%b1%e5%a5%96%ef%bc%81%e8%80%90%e7%ab%8b%e5%85%8b%e8%81%94%e5%90%88bcl-2%e6%8a%91%e5%88%b6%e5%89%82a\/","title":{"rendered":"\u3010\u76f4\u51fbASH 2024\u3011\u65a9\u83b7\u6458\u8981\u6210\u5c31\u5956\uff01\u8010\u7acb\u514b\u00ae\u8054\u5408Bcl-2\u6291\u5236\u5242APG-2575\u6570\u636e\u9996\u6b21\u516c\u5e03\uff0c\u65e0\u5316\u7597\u6cbb\u7597\u513f\u7ae5R\/R Ph+ ALL\u8868\u73b0\u4f18\u5f02"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u7b49\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c66\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86\u516c\u53f8\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u7814\u53d1\u4ee3\u53f7\uff1aHQP1351\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u8054\u5408\u516c\u53f8\u539f\u7814Bcl-2\u6291\u5236\u5242APG-2575\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08R\/R Ph+ ALL\uff09\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u6570\u636e\u3002\u8fd9\u662f\u4e9a\u76db\u533b\u836f\u4e24\u4e2a\u91cd\u78c5\u54c1\u79cd\u8054\u5408\u6cbb\u7597\u6570\u636e\u7684\u9996\u6b21\u62ab\u9732\uff0c\u5e76\u8363\u83b7\u672c\u5c4aASH\u5e74\u4f1a\u7684&#8221;\u6458\u8981\u6210\u5c31\u5956&#8221;\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/891219\/Ascentage_Pharma_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684&#8221;\u4e2d\u56fd\u58f0\u97f3&#8221;\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u56db\u4e2a\u54c1\u79cd\uff08\u8010\u7acb\u514b\u00ae\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9879\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u8fdb\u5c55\u5165\u9009ASH\u5e74\u4f1a\u5c55\u793a\u53ca\u62a5\u544a\uff0c\u5176\u4e2d\u4e24\u9879\u83b7\u53e3\u5934\u62a5\u544a\u3002<\/p>\n<p>\u8fd9\u9879\u9488\u5bf9R\/R Ph+ ALL\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\u521d\u6b65\u9a8c\u8bc1\u4e86\u5965\u96f7\u5df4\u66ff\u5c3c\u4e0eAPG-2575\u8054\u5408\u6cbb\u7597\u7684\u7597\u6548\u6f5c\u529b\u548c\u5b89\u5168\u6027\u4f18\u52bf\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u65b9\u6848\u5728\u65e0\u9700\u5f3a\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u5b9e\u73b0\u4e8683.3%\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u548c71.4%\u7684\u53ef\u6d4b\u91cf\u6b8b\u7559\u75be\u75c5\uff08MRD\uff09\u8f6c\u9634\u7387\u3002<\/p>\n<p>\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u8be5\u54c1\u79cd\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55TKI\u8010\u836f\uff0c\u5e76\u4f34\u6709T315I\u7a81\u53d8\u7684CML-CP\u6216CML-\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u5bf9\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u836f\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8010\u7acb\u514b\u00ae\u5728\u4e2d\u56fd\u7684\u5546\u4e1a\u5316\u63a8\u5e7f\u7531\u4e9a\u76db\u533b\u836f\u548c\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u8d1f\u8d23\u3002<\/p>\n<p>\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\u7afa\u6653\u51e1\u6559\u6388\u8868\u793a\uff1a&#8221;\u8fd1\u5e74\u6765\u6211\u56fd\u513f\u7ae5\u8840\u6db2\u75c5\u6574\u4f53\u8bca\u6cbb\u6c34\u5e73\u5df2\u6709\u5927\u5e45\u63d0\u5347\uff0c\u4f46\u662f\u5728Ph+ ALL\u9886\u57df\uff0c\u56e0\u4e3a\u5176\u75be\u75c5\u7684\u7279\u6b8a\u6027\uff0c\u6574\u4f53\u9884\u540e\u4f9d\u7136\u8f83\u5dee\uff0cR\/R Ph+ ALL\u6cbb\u7597\u4ecd\u6709\u5f88\u5927\u7684\u63a2\u7d22\u7a7a\u95f4\u3002\u73b0\u5728\u7b2c\u4e09\u4ee3BCR-ABL1\u6291\u5236\u5242\u5965\u96f7\u5df4\u66ff\u5c3c\u8054\u5408Bcl-2\u6291\u5236\u5242APG-2575\u7684\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u63d0\u793a\uff0c\u5728\u65e0\u9700\u5f3a\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u60a3\u513f\u53ef\u4ee5\u83b7\u5f97\u76f8\u5f53\u4e0d\u9519\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u548c\u6b8b\u7559\u75be\u75c5\u8f6c\u9634\u7387\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6211\u4eec\u671f\u5f85\u5728\u63a5\u4e0b\u6765\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u4e00\u6b65\u786e\u5b9a\u4e24\u836f\u8054\u5408\u7684\u5408\u9002\u5242\u91cf\u548c\u65b9\u6848\u3002\u4e3aR\/R Ph+ ALL\u513f\u7ae5\u60a3\u8005\uff0c\u63a2\u7d22\u66f4\u591a\u5b89\u5168\u4e14\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002&#8221;<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a&#8221;\u8fd9\u662f\u516c\u53f8\u4e24\u4e2a\u91cd\u78c5\u54c1\u79cd\u8010\u7acb\u514b\u00ae\u548cAPG-2575\u7684\u9996\u6b21\u8054\u7528\u3002\u5728\u8fd9\u4e00\u6cbb\u7597\u65b9\u6848\u4e2d\uff0cPh+ ALL\u513f\u7ae5\u60a3\u8005\u5728\u65e0\u5316\u7597\u7684\u60c5\u51b5\u4e0b\u4ecd\u83b7\u5f97\u5353\u8d8a\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u8d77\u6548\u8fc5\u901f\uff0c\u7f13\u89e3\u7387\u9ad8\u4e14\u7f13\u89e3\u7a0b\u5ea6\u6df1\u3002\u8fd9\u610f\u5473\u7740\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u6709\u671b\u6210\u4e3aPh+ ALL\u8fdb\u5165&#8217;\u65e0\u5316\u7597&#8217;\u65f6\u4ee3\u7684\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u575a\u5b88&#8217;\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&#8217;\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002&#8221;<\/p>\n<p>\u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n<p>Safety and Efficacy of Olverembatinib (HQP1351) Combined with Lisaftoclax\u00a0(APG-2575) in Children and Adolescents with Relapsed\/Refractory Philadelphia Chromosome\u2013Positive Acute Lymphoblastic Leukemia (R\/R Ph+ ALL): First Report from a Phase 1 Study<br \/>\u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u8054\u5408Lisaftoclax\uff08APG-2575\uff09\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08R\/R Ph+ ALL\uff09\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\uff1a\u4e00\u9879I\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u9996\u6b21\u62a5\u544a<br \/>\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u62a5\u5c55\u793a<br \/>\u6458\u8981\u7f16\u53f7\uff1a1443<br \/>\u5206\u4f1a\u573a\uff1a613. \u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff1a\u540c\u79cd\u79fb\u690d\u4ee5\u5916\u7684\u7597\u6cd5\uff1a\u58c1\u62a5\u5c55\u793aI<br \/>\u6838\u5fc3\u8981\u70b9\uff1a<br \/>\u7814\u7a76\u80cc\u666f\uff1a\u5965\u96f7\u5df4\u66ff\u5c3c\u662f\u65b0\u578b\u4e09\u4ee3TKI\uff0c\u5177\u6709\u826f\u597d\u8010\u53d7\u6027\uff0c\u5e76\u5728\u5df2\u63a5\u53d7\u6df1\u5ea6\u6cbb\u7597\u7684CP-CML\u60a3\u8005\u4e2d\uff08\u65e0\u8bba\u662f\u5426\u6709T315I\u7a81\u53d8\uff09\u8868\u73b0\u51fa\u5f3a\u5927\u4e14\u6301\u4e45\u7684\u6297\u767d\u8840\u75c5\u6d3b\u6027\u3002Lisaftoclax\u662f\u4e00\u79cd\u65b0\u578bBcl-2\u6291\u5236\u5242\uff0c\u5728\u591a\u79cd\u8840\u6db2\u6076\u6027\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u6297\u80bf\u7624\u6548\u679c\u3002\u76ee\u524d\uff0cR\/R Ph+ ALL\u513f\u7ae5\u60a3\u8005\u5c1a\u65e0\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<p>\u7814\u7a76\u4ecb\u7ecd\uff1a\u672c\u7814\u7a76\u65e8\u5728\u63a2\u7d22\u5965\u96f7\u5df4\u66ff\u5c3c\u5355\u836f\u6216\u8054\u5408Lisaftoclax\u5728R\/R Ph+ ALL\u513f\u7ae5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u7279\u5f81\u3002<\/p>\n<p>\u5165\u7ec4\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a<\/p>\n<p>\u8fd9\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u7684Ib\u671f\u7814\u7a76\uff0c\u5165\u7ec4\u7684\u4e3a\u5e74\u9f84\u5c0f\u4e8e18\u5c81\u7684R\/R Ph+ ALL\u513f\u7ae5\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5bf9\u81f3\u5c11\u4e00\u79cdTKI\u8010\u836f\u6216\u4e0d\u8010\u53d7\uff08\u5982\u679c\u60a3\u8005\u643a\u5e26T315I\u7a81\u53d8\uff0c\u5219\u4e0d\u8003\u8651\u65e2\u5f80TKI\u4f7f\u7528\u60c5\u51b5\uff09\u3002\u60a3\u8005\u9700\u5177\u5907\u8db3\u591f\u7684Karnofsky\/Lansky\u529f\u80fd\u72b6\u6001\u8bc4\u5206\u548c\u5668\u5b98\u529f\u80fd\u3002\u60a3\u6709\u4e0ePh+ ALL\u65e0\u5173\u7684\u75c7\u72b6\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6216\u663e\u8457\u51fa\u8840\u7684\u60a3\u8005\u88ab\u6392\u9664\u5728\u5916\u3002\u5965\u96f7\u5df4\u66ff\u5c3c\u4ee5\u6210\u4eba\u7b49\u6548\u5242\u91cf\uff08AED\uff0940 mg\u53e3\u670d\uff0c\u9694\u65e5\u4e00\u6b21\uff0c\u6301\u7eed2\u5468\uff08\u7b2c1-14\u5929\uff09\u3002\u7136\u540e\u540c\u5242\u91cf\u7684\u5965\u96f7\u5df4\u66ff\u5c3c\u8054\u5408Lisaftoclax\uff0c\u540e\u8005\u7684\u6307\u5b9a\u5242\u91cf\u4e3a200\/400\/600 mg\uff08AED\uff09\uff0c\u6bcf\u65e5\u4e00\u6b21\uff08QD\uff09\uff0c\u7b2c13-42\u5929\uff08\u7b2c13-15\u5929\u97003\u5929\u5242\u91cf\u9012\u589e\uff09\u3002\u5730\u585e\u7c73\u677e\u4ee56 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mg\uff08AED\uff09\u6307\u5b9a\u5242\u91cf\u7684Lisaftoclax\u3002\u8fd9\u4e9b\u60a3\u513f\u5b8c\u6210\u4e8642\u5929\u7684\u6cbb\u7597\uff0c\u5e76\u63a5\u53d7\u4e86\u4e3b\u8981\u7ec8\u70b9\u8bc4\u4f30\u3002<\/p>\n<p>\u7597\u6548\u6570\u636e\uff1a\u57286\u4f8b\u5f62\u6001\u5b66\u53cd\u5e94\u53ef\u8bc4\u4f30\u7684\u60a3\u513f\u4e2d\uff0c\u5728\u5965\u96f7\u5df4\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u7ed3\u675f\u65f6\uff08EOM\uff09\uff0c2\u4f8b\u8fbe\u5230CR\u4f34\u4e0d\u5b8c\u5168\u8840\u7ec6\u80de\u6062\u590d\uff08CRi\uff09\uff0c2\u4f8b\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0cORR\uff08CR+CRi\uff09\u4e3a33.3%\uff1b\u5728\u5965\u96f7\u5df4\u66ff\u5c3c\u548cLisaftoclax\u8054\u5408\u6cbb\u7597\u7ed3\u675f\u65f6\uff08EOC\uff09\uff0c5\u4f8b\uff0883.3%\uff09\u8fbe\u5230CR\uff1b\u57287\u4f8b\u5206\u5b50\u5b66\u53ef\u8bc4\u4f30\u7684\u60a3\u513f\u4e2d\uff0c\u67095\uff0871.4%\uff09\u4f8b\u8fbe\u5230\u4e86MRD\u9634\u6027\uff0c\u5176\u4e2d1\u4f8b\u5728EOM\u8fbe\u5230\uff0c4\u4f8b\u5728EOC\u8fbe\u5230\u3002<\/p>\n<p>\u5b89\u5168\u6027\u6570\u636e\uff1a<\/p>\n<p>10\u4f8b\u60a3\u513f\u4e2d\u67096\u4f8b\u7ecf\u5386\u4e86\u2265 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Ph+ ALL\u60a3\u513f\u63d0\u4f9b\u4e86\u4e00\u79cd\u5b89\u5168\u4e14\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002\u8be5\u65b9\u6848\u5728\u65e0\u9700\u5f3a\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u5b9e\u73b0\u4e8683.3%\u7684CR\u7387\u548c71.4%\u7684MRD\u8f6c\u9634\u7387\u3002\u76ee\u524d\uff0c\u8be5\u7814\u7a76\u6b63\u5904\u4e8e\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u3002<\/p>\n<p>\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7efc\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u521b\u65b0\u836f\uff0c\u4ee5\u89e3\u51b3\u80bf\u7624\u7b49\u9886\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u5df2\u5efa\u7acb\u4e30\u5bcc\u7684\u521b\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP 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Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b66\u7b49\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u5df2\u6784\u5efa\u5728\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u9886\u57df\u7ecf\u9a8c\u4e30\u5bcc\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u4e0e\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c&#8221;\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&#8221;\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n<p>\u524d\u77bb\u6027\u58f0\u660e<\/p>\n<p>\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n<p>\u00a0<\/p>\n<p>SOURCE 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ALL\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\u521d\u6b65\u9a8c\u8bc1\u4e86\u5965\u96f7\u5df4\u66ff\u5c3c\u4e0eAPG-2575\u8054\u5408\u6cbb\u7597\u7684\u7597\u6548\u6f5c\u529b\u548c\u5b89\u5168\u6027\u4f18\u52bf\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u65b9\u6848\u5728\u65e0\u9700\u5f3a\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u5b9e\u73b0\u4e8683.3%\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u548c71.4%\u7684\u53ef\u6d4b\u91cf\u6b8b\u7559\u75be\u75c5\uff08MRD\uff09\u8f6c\u9634\u7387\u3002 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ALL\u6cbb\u7597\u4ecd\u6709\u5f88\u5927\u7684\u63a2\u7d22\u7a7a\u95f4\u3002\u73b0\u5728\u7b2c\u4e09\u4ee3BCR-ABL1\u6291\u5236\u5242\u5965\u96f7\u5df4\u66ff\u5c3c\u8054\u5408Bcl-2\u6291\u5236\u5242APG-2575\u7684\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u63d0\u793a\uff0c\u5728\u65e0\u9700\u5f3a\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u60a3\u513f\u53ef\u4ee5\u83b7\u5f97\u76f8\u5f53\u4e0d\u9519\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u548c\u6b8b\u7559\u75be\u75c5\u8f6c\u9634\u7387\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6211\u4eec\u671f\u5f85\u5728\u63a5\u4e0b\u6765\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u4e00\u6b65\u786e\u5b9a\u4e24\u836f\u8054\u5408\u7684\u5408\u9002\u5242\u91cf\u548c\u65b9\u6848\u3002\u4e3aR\/R Ph+ ALL\u513f\u7ae5\u60a3\u8005\uff0c\u63a2\u7d22\u66f4\u591a\u5b89\u5168\u4e14\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002&#8221; 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ALL\u8fdb\u5165&#8217;\u65e0\u5316\u7597&#8217;\u65f6\u4ee3\u7684\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u575a\u5b88&#8217;\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&#8217;\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002&#8221; \u6b64\u9879\u7814\u7a76\u57282024 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Safety and Efficacy of Olverembatinib (HQP1351) Combined with Lisaftoclax\u00a0(APG-2575) in Children and Adolescents with Relapsed\/Refractory Philadelphia Chromosome\u2013Positive Acute Lymphoblastic Leukemia (R\/R Ph+ ALL): First Report from a Phase 1 Study\u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u8054\u5408Lisaftoclax\uff08APG-2575\uff09\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08R\/R Ph+ [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":5488,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-5487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u3010\u76f4\u51fbASH 2024\u3011\u65a9\u83b7\u6458\u8981\u6210\u5c31\u5956\uff01\u8010\u7acb\u514b\u00ae\u8054\u5408Bcl-2\u6291\u5236\u5242APG-2575\u6570\u636e\u9996\u6b21\u516c\u5e03\uff0c\u65e0\u5316\u7597\u6cbb\u7597\u513f\u7ae5R\/R Ph+ ALL\u8868\u73b0\u4f18\u5f02 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u3010\u76f4\u51fbash-2024\u3011\u65a9\u83b7\u6458\u8981\u6210\u5c31\u5956\uff01\u8010\u7acb\u514b\u8054\u5408bcl-2\u6291\u5236\u5242a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u51fbASH 2024\u3011\u65a9\u83b7\u6458\u8981\u6210\u5c31\u5956\uff01\u8010\u7acb\u514b\u00ae\u8054\u5408Bcl-2\u6291\u5236\u5242APG-2575\u6570\u636e\u9996\u6b21\u516c\u5e03\uff0c\u65e0\u5316\u7597\u6cbb\u7597\u513f\u7ae5R\/R Ph+ ALL\u8868\u73b0\u4f18\u5f02 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2024\u5e7412\u670810\u65e5 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