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\n

\n <\/a><\/p>\n

\n <\/p>\n<\/div>\n

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MET\u662f\u4e00\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5728\u7ec6\u80de\u7684\u6b63\u5e38\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002[8] MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u53ef\u5bfc\u81f4\u80bf\u7624\u751f\u957f\u4ee5\u53ca\u764c\u7ec6\u80de\u7684\u8f6c\u79fb\u8fdb\u5c55\uff0c\u4e14\u662fEGFR\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5bf9EGFR TKI\u6cbb\u7597\u4ea7\u751f\u83b7\u5f97\u6027\u8010\u836f\u7684\u4e3b\u8981\u673a\u5236\u4e4b\u4e00\u3002[8],[9] \u7ea6\u67092-3%\u7684\u60a3\u8005\u4f34\u6709MET\u5916\u663e\u5b5014\u8df3\u53d8\uff0c\u8fd9\u662f\u4e00\u79cd\u53ef\u9776\u5411\u7684MET\u57fa\u56e0\u7a81\u53d8\u3002[10]\u00a0MET \u5f02\u5e38\u662f\u5bf9\u7b2c\u4e00\/\u4e8c\u4ee3\u00a0EGFR TKI \u4ee5\u53ca\u6cf0\u745e\u6c99\u00ae\u7b49\u7b2c\u4e09\u4ee3EGFR TKI\u4ea7\u751f\u8010\u836f\u6027\u7684\u4e3b\u8981\u673a\u5236\u3002\u00a0\u5728\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u7ea6\u6709\u00a015-50% \u51fa\u73b0\u00a0MET \u5f02\u5e38\u3002[11],[12],[13],[14],[15]\u00a0MET\u5f02\u5e38\u7684\u53d1\u751f\u7387\u53ef\u80fd\u56e0\u6837\u54c1\u7c7b\u578b\u3001\u68c0\u6d4b\u65b9\u6cd5\u548c\u4f7f\u7528\u7684\u6d4b\u5b9a\u9608\u503c\u800c\u5f02\u3002[16]<\/p>\n

\u5173\u4e8e\u6c83\u745e\u6c99\u00ae\uff08\u8d5b\u6c83\u66ff\u5c3c\uff09<\/p>\n

\u6c83\u745e\u6c99\u00ae\u662f\u4e00\u79cd\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684\u53e3\u670dMET TKI\uff0c\u5728\u665a\u671f\u5b9e\u4f53\u7624\u4e2d\u8868\u73b0\u51fa\u4e34\u5e8a\u6d3b\u6027\u3002\u6c83\u745e\u6c99\u00ae\u53ef\u963b\u65ad\u56e0\u7a81\u53d8\uff08\u4f8b\u5982\u5916\u663e\u5b5014\u8df3\u53d8\u6216\u5176\u4ed6\u70b9\u7a81\u53d8\uff09\u3001\u57fa\u56e0\u6269\u589e\u6216\u86cb\u767d\u8d28\u8fc7\u8868\u8fbe\u800c\u5bfc\u81f4\u7684MET\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u4fe1\u53f7\u901a\u8def\u7684\u5f02\u5e38\u6fc0\u6d3b\u3002<\/p>\n

\u6c83\u745e\u6c99\u00ae\u65e9\u524d\u5df2\u4e8e2021\u5e746\u6708\u5728\u4e2d\u56fd\u53d6\u5f97\u9644\u6761\u4ef6\u6279\u51c6<\/a>\uff0c\u7528\u4e8e\u6cbb\u7597\u63a5\u53d7\u5168\u8eab\u6027\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u65e0\u6cd5\u63a5\u53d7\u5316\u7597\u7684MET\u5916\u663e\u5b5014\u8df3\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002\u6c83\u745e\u6c99\u00ae\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u7684\u9009\u62e9\u6027MET\u6291\u5236\u5242\uff0c\u5e76\u81ea2023\u5e743\u6708\u8d77\u83b7\u7eb3\u5165<\/a>\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u6c83\u745e\u6c99\u00ae\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\u6216\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\uff0c\u4ea6\u6b63\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u80ba\u764c\u3001\u80be\u764c\u548c\u80c3\u764c\u5728\u5185\u7684\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u3002<\/p>\n

\u4e8e2011\u5e74\uff0c\u548c\u9ec4\u533b\u836f\u4e0e\u963f\u65af\u5229\u5eb7\u8fbe\u6210\u4e00\u9879\u5168\u7403\u8bb8\u53ef\u534f\u8bae\uff0c\u65e8\u5728\u5171\u540c\u5f00\u53d1\u6c83\u745e\u6c99\u00ae\u5e76\u4fc3\u8fdb\u5176\u5546\u4e1a\u5316\u3002\u6c83\u745e\u6c99\u00ae\u7684\u5408\u4f5c\u4e34\u5e8a\u5f00\u53d1\u5728\u4e2d\u56fd\u7531\u548c\u9ec4\u533b\u836f\u4e3b\u5bfc\uff0c\u5728\u6d77\u5916\u5219\u7531\u963f\u65af\u5229\u5eb7\u4e3b\u5bfc\u3002\u6b64\u5916\uff0c\u548c\u9ec4\u533b\u836f\u8d1f\u8d23\u6c83\u745e\u6c99\u00ae\u5728\u4e2d\u56fd\u7684\u4e0a\u5e02\u8bb8\u53ef\u3001\u751f\u4ea7\u548c\u4f9b\u5e94\uff0c\u800c\u963f\u65af\u5229\u5eb7\u5219\u8d1f\u8d23\u5b9e\u73b0\u6c83\u745e\u6c99\u00ae\u5728\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u8303\u56f4\u5185\u7684\u5546\u4e1a\u5316\u3002\u6c83\u745e\u6c99\u00ae\u7684\u9500\u552e\u6536\u5165\u5c06\u7531\u963f\u65af\u5229\u5eb7\u786e\u8ba4\u3002<\/p>\n

\u5173\u4e8e\u548c\u9ec4\u533b\u836f<\/p>\n

\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1awww.hutch\u2011med.com<\/a>\u6216\u5173\u6ce8\u6211\u4eec\u7684\u9886\u82f1<\/a>\u4e13\u9875\u3002<\/p>\n

\u524d\u77bb\u6027\u9648\u8ff0<\/p>\n

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\u533b\u7597\u4fe1\u606f<\/p>\n

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\n

[1]\u00a0\u00a0 EGFR = \u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 (epidermal growth factor receptor); TKI = \u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291 (tyrosine kinase inhibitor).<\/span><\/p>\n

[2]\u00a0\u00a0 World Health Organization. International Agency for Research on Cancer. All cancers fact sheet. Available at: https:\/\/gco.iarc.fr\/today\/\u00addata\/factsheets\/cancers\/39-All-cancers-fact-sheet.pdf. Accessed November 2022.<\/span><\/p>\n

[3]\u00a0\u00a0 American Cancer Society. What is Lung Cancer? Available at: https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html. Accessed November 2022.<\/span><\/p>\n

[4]\u00a0\u00a0 Knight SB, et al. Progress and prospects of early detection in lung cancer. Open Biol. 2017;7(9): 170070.<\/span><\/p>\n

[5]\u00a0\u00a0 Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27.<\/span><\/p>\n

[6]\u00a0\u00a0 Zhang Y, et al. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget. 2016;7(48).<\/span><\/p>\n

[7]\u00a0\u00a0 Szumera-Cie\u0107kiewicz A, et al.\u202fEGFR Mutation Testing on Cytological and Histological Samples in 11. Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence.\u202fInt J Clin Exp Pathol. 2013:6;2800-12.<\/span><\/p>\n

[8]\u00a0\u00a0 Uchikawa E, et al. Structural basis of the activation of c-MET receptor. Nat Commun. 2021;12(4074).<\/span><\/p>\n

[9]\u00a0\u00a0 Wang Q, et al. MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer. Journal of Hematology & Oncology. 2019;63.<\/span><\/p>\n

[10]\u00a0 Vuong HG, et al. Clinicopathological implications of MET exon 14 mutations in non-small cell lung cancer \u2013 A systematic review and meta-analysis. Lung Cancer.\u00a02018; 123: 76-82.<\/span><\/p>\n

[11]\u00a0 Soria JC, et al. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(2):113-125.<\/span><\/p>\n

[12]\u00a0 Mok TS, et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017;376(7):629-640.<\/span><\/p>\n

[13]\u00a0 Hartmaier R, et al. Tumor genomics in patients (pts) with advanced epidermal growth factor receptor mutant (EGFRm) non-small cell lung cancer (NSCLC) whose disease has progressed on first-line (1L) osimertinib therapy in the Phase II ORCHARD study. Cancer Res\u00a015 June 2022; 82 (12_Supplement):\u00a0LB078.<\/span><\/p>\n

[14]\u00a0 Piotrowska, et al.\u00a0 MET amplification (amp) as a resistance mechanism to osimertinib. Journal of Clinical Oncology 2017 35:15_suppl, 9020-9020.\u00a0<\/span><\/p>\n

[15]\u00a0 Hartmaier, et al. Detection of MET-mediated EGFR tyrosine kinase inhibitor (TKI) resistance in advanced non-small cell lung cancer (NSCLC): biomarker analysis of the TATTON study. Cancer Res (2019) 79 (13_Supplement): 4897.<\/span><\/p>\n

[16]\u00a0 Coleman N, et al. Beyond epidermal growth factor receptor: MET amplification as a general resistance driver to targeted therapy in oncogene-driven non-small-cell lung cancer. ESMO Open. 2019;6(6).<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

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\u533b\u7597\u4fe1\u606f \u672c\u65b0\u95fb\u7a3f\u6240\u63d0\u5230\u7684\u4ea7\u54c1\u53ef\u80fd\u5e76\u672a\u5728\u6240\u6709\u56fd\u5bb6\u4e0a\u5e02\uff0c\u6216\u53ef\u80fd\u4ee5\u4e0d\u540c\u7684\u5546\u6807\u8fdb\u884c\u9500\u552e\uff0c\u6216\u7528\u4e8e\u4e0d\u540c\u7684\u75c5\u75c7\uff0c\u6216\u91c7\u7528\u4e0d\u540c\u7684\u5242\u91cf\uff0c\u6216\u62e5\u6709\u4e0d\u540c\u7684\u6548\u529b\u3002\u672c\u6587\u4e2d\u6240\u5305\u542b\u7684\u4efb\u4f55\u4fe1\u606f\u90fd\u4e0d\u5e94\u88ab\u770b\u4f5c\u662f\u4efb\u4f55\u5904\u65b9\u836f\u7684\u7533\u8bf7\u3001\u63a8\u5e7f\u6216\u5e7f\u544a\uff0c\u5305\u62ec\u90a3\u4e9b\u6b63\u5728\u7814\u53d1\u7684\u836f\u7269\u3002 [1]\u00a0\u00a0 EGFR = \u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 (epidermal growth factor receptor); TKI = […]<\/p>\n","protected":false},"author":0,"featured_media":6662,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-6661","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u6c83\u745e\u6c99\u00ae (\u8d5b\u6c83\u66ff\u5c3c) \u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u5e38\u89c4\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027MET\u5916\u663e\u5b5014\u975e\u5c0f\u7ec6\u80de\u80ba\u764c - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u6c83\u745e\u6c99-\u8d5b\u6c83\u66ff\u5c3c-\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u548c\u9ec4\u533b\u836f\u5ba3\u5e03\u6c83\u745e\u6c99\u00ae (\u8d5b\u6c83\u66ff\u5c3c) \u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u5e38\u89c4\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027MET\u5916\u663e\u5b5014\u975e\u5c0f\u7ec6\u80de\u80ba\u764c - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u2014 \u9002\u5e94\u75c7\u6269\u5c55\u81f3\u6db5\u76d6\u521d\u6cbb\u60a3\u8005 \u2014\u2014 2021\u5e74\u53d6\u5f97\u7684\u6cbb\u7597\u7ecf\u6cbb\u60a3\u8005\u7684\u9644\u6761\u4ef6\u6279\u51c6\u8f6c\u4e3a\u5e38\u89c4\u6279\u51c6\u00a0\u2014 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