{"id":6673,"date":"2025-01-14T08:40:00","date_gmt":"2025-01-14T08:40:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e9%99%86%e9%81%93%e5%9f%b9%e5%8c%bb%e5%ad%a6%e5%9b%a2%e9%98%9f%e5%9c%a8blood%e6%9d%82%e5%bf%97%e5%8f%91%e8%a1%a8cd7-car-t%e6%b2%bb%e7%96%97%e6%80%a5%e6%80%a7%e9%ab%93%e7%b3%bb%e7%99%bd%e8%a1%80\/"},"modified":"2025-01-14T08:40:00","modified_gmt":"2025-01-14T08:40:00","slug":"%e9%99%86%e9%81%93%e5%9f%b9%e5%8c%bb%e5%ad%a6%e5%9b%a2%e9%98%9f%e5%9c%a8blood%e6%9d%82%e5%bf%97%e5%8f%91%e8%a1%a8cd7-car-t%e6%b2%bb%e7%96%97%e6%80%a5%e6%80%a7%e9%ab%93%e7%b3%bb%e7%99%bd%e8%a1%80","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e9%99%86%e9%81%93%e5%9f%b9%e5%8c%bb%e5%ad%a6%e5%9b%a2%e9%98%9f%e5%9c%a8blood%e6%9d%82%e5%bf%97%e5%8f%91%e8%a1%a8cd7-car-t%e6%b2%bb%e7%96%97%e6%80%a5%e6%80%a7%e9%ab%93%e7%b3%bb%e7%99%bd%e8%a1%80\/","title":{"rendered":"\u9646\u9053\u57f9\u533b\u5b66\u56e2\u961f\u5728Blood\u6742\u5fd7\u53d1\u8868CD7 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href=\"https:\/\/mma.prnewswire.com\/media\/2597443\/image_1.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<\/div>\n<p>\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u9646\u4f69\u534e\u9662\u957f\u5e26\u9886\u56e2\u961f\u521b\u65b0\u6027\u5730\u91c7\u7528\u57fa\u4e8e\u7eb3\u7c73\u6297\u4f53\u7684CD7 CAR-T\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff0c\u7814\u7a76\u7ed3\u679c\u4e0d\u4ec5\u5728\u80bf\u7624\u6740\u4f24\u529b\u548c\u5b89\u5168\u6027\u4e0a\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u66f4\u4e3a\u96be\u6cbb\u590d\u53d1\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7684\u6cbb\u7597\u5f00\u8f9f\u4e86\u65b0\u8def\u5f84\u3002<\/p>\n<p 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NS7CAR-T\u4ea7\u54c1\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\uff0c\u4ee5\u53ca\u5728\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d(<a href=\"https:\/\/clinicaltrials.gov\/\">https:\/\/clinicaltrials.gov<\/a> NCT04938115)\u00a0 Nanobody-based NS7CAR-T\u6cbb\u7597\u96be\u6cbb\/\u590d\u53d1CD7\u9633\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7ed3\u679c\u3002<\/p>\n<p class=\"prntac\">\u7814\u7a76\u65b9\u6cd5<\/p>\n<p>\u57fa\u4e8e\u7eb3\u7c73\u6297\u4f53\u7684dVHH NS7CAR\u5305\u542b\u4e24\u4e2a\u6297CD7\u7eb3\u7c73\u6297\u4f53\uff08VHHs\uff09\u7684\u7f16\u7801\u533a\u57df\uff0c\u8fd9\u4e9b\u533a\u57df\u901a\u8fc7\u4e00\u4e2a\u8fde\u63a5\u5b50(G4S\uff095\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u4ee5\u53caCD8\u03b1\u94f0\u94fe\u533a\u57df\u3001CD8\u03b1\u8de8\u819c\u57df\uff0c\u8fd8\u6709\u4e00\u4e2a\u7b2c\u4e8c\u4ee3CAR\u7ec6\u80de\u9aa8\u67b6\uff0c\u5176\u5728\u7ec6\u80de\u5185\u5171\u523a\u6fc0\u57df\u5305\u542b4-1BB\u548cCD3\u03b6\u3002\u5236\u5907\u65f6\uff0c\u901a\u8fc7\u767d\u7ec6\u80de\u91c7\u96c6\u672f\u83b7\u5f97\u5916\u5468\u8840(PB)\u5355\u6838\u7ec6\u80de\uff0c\u5206\u79bbT\u7ec6\u80de\u5e76\u7528\u6162\u75c5\u6bd2\u8f6c\u5bfc\u3002\u7b2c\u4e8c\u4ee3CD7CAR\u7531\u6297CD7\u5355\u94fe\u6297\u4f53\u3001IgG4\u94f0\u94fe\u533a\u3001CD28TM\u8de8\u819c\u7ed3\u6784\u57df\u30014-1BB\u548cCD3\u03b6\u7684\u80de\u5185\u5171\u523a\u6fc0\u7ed3\u6784\u57df\u53ca\u622a\u77edEGFR\u86cb\u767d\u901a\u8fc7T2A\u8fde\u63a5\u6784\u6210\u3002\u6240\u6709\u60a3\u8005\u5728CD7CAR-T\u56de\u8f933\u5929\u524d\u9759\u6ce8\u6c1f\u8fbe\u62c9\u6ee8(30 mg\/m2\/d)\u548c\u73af\u78f7\u9170\u80fa(300 mg\/m2\/d)\u3002\u4ece\u91c7\u96c6\u5230CAR-T\u7ec6\u80de\u8f93\u6ce8\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a15\u5929\u3002<\/p>\n<p class=\"prntac\">\u7814\u7a76\u7ed3\u679c<\/p>\n<p>\u9996\u5148\u662f\u4e34\u5e8a\u524d\u7814\u7a76\uff0cdVHH NS7CAR-T\u548c\u4f20\u7edfscFV NS7CAR\u7684<span>\u7ed3\u6784\u5bf9\u6bd4<\/span>\u3002\u7814\u7a76\u53d1\u73b0\uff0cdVHH NS7CAR-T\u7ec6\u80de\u5728\u57f9\u517b\u5927\u7ea6\u4e24\u5468\u540e\u663e\u793a\u51fa\u6bd4scFv NS7CAR-T\u66f4\u5f3a\u7684\u6269\u589e\u80fd\u529b\uff0823.9 folds vs.8.1 folds\uff0cP=0.024\uff09\u3002<\/p>\n<p>\u5728\u4e0d\u540c\u7684\u6548\u5e94\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u6bd4\u4f8b\u4e0b\uff0cscFv\u548cdVHH 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\/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9646\u9053\u57f9\u533b\u5b66\u56e2\u961f\u5728Blood\u6742\u5fd7\u53d1\u8868CD7 CAR-T\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6700\u65b0\u7814\u7a76 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u5317\u4eac2025\u5e741\u670814\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u8fd1\u65e5\uff0c\u9646\u9053\u57f9\u533b\u9662\u9646\u4f69\u534e\u9662\u957f\u4f5c\u4e3a\u7b2c\u4e00\u4f5c\u8005\u548c\u901a\u8baf\u4f5c\u8005\uff0c\u5728\u56fd\u9645\u8840\u6db2\u5b66\u6743\u5a01\u671f\u520aBlood\uff08IF=21\uff09\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a&#8221;Nanobody-based Naturally Selected CD7-Targeted Chimeric Antigen Receptor T Cell Therapy for Acute Myeloid Leukemia&#8221;\u7684\u7814\u7a76\u8bba\u6587\u3002\u8fd9\u9879\u7814\u7a76\u6210\u679c\u6807\u5fd7\u7740\u5728\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u6cbb\u7597\u9886\u57df\u7684\u53c8\u4e00\u91cd\u5927\u7a81\u7834\u3002 \u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u9646\u4f69\u534e\u9662\u957f\u5e26\u9886\u56e2\u961f\u521b\u65b0\u6027\u5730\u91c7\u7528\u57fa\u4e8e\u7eb3\u7c73\u6297\u4f53\u7684CD7 CAR-T\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff0c\u7814\u7a76\u7ed3\u679c\u4e0d\u4ec5\u5728\u80bf\u7624\u6740\u4f24\u529b\u548c\u5b89\u5168\u6027\u4e0a\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u66f4\u4e3a\u96be\u6cbb\u590d\u53d1\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7684\u6cbb\u7597\u5f00\u8f9f\u4e86\u65b0\u8def\u5f84\u3002 \u7814\u7a76\u80cc\u666f 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\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u7684\u4f20\u7edf\u9776\u5411\u57df\u4f9d\u8d56\u4e8e\u5355\u514b\u9686\u6297\u4f53\uff08mAbs\uff09\u4e2d\u7684IgG\u53d8\u91cf\u533a\u57df\u7684\u5355\u94fe\u7247\u6bb5\uff08scFv\uff09\u3002\u6700\u8fd1\uff0c\u4e00\u79cd\u5229\u7528\u7f8a\u9a7c\u79d1\u91cd\u94fe\u6297\u4f53\u7684\u5355\u53d8\u91cf\u57df\uff0c\u5373\u6240\u8c13\u7684\u7eb3\u7c73\u6297\u4f53\uff0c\u4f5c\u4e3a\u4e00\u79cd\u66ff\u4ee3\u65b9\u6cd5\uff0c\u5df2\u7ecf\u53d8\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981\u3002\u7eb3\u7c73\u6297\u4f53\u7684\u5206\u5b50\u5927\u5c0f\uff0815kDa\uff09\u5927\u7ea6\u662f\u4ebaIgG\u5206\u5b50\u7684\u5341\u5206\u4e4b\u4e00\u3002\u867d\u7136\u4f20\u7edf\u7684mAbs\u9700\u8981\u516d\u4e2a\u4e92\u8865\u51b3\u5b9a\u533a\uff08CDRs\uff09\u6765\u7ed3\u5408\u6297\u539f\uff0c\u4f46\u7eb3\u7c73\u6297\u4f53\u4ec5\u7528\u4e09\u4e2aCDRs\u5c31\u80fd\u7ef4\u6301\u76f8\u5f53\u7684\u4eb2\u548c\u529b\u548c\u7279\u5f02\u6027\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u5b83\u4eec\u4e0e\u4eba\u7c7bVH\u57fa\u56e0\u5bb6\u65cfIII\u7684\u76f8\u4f3c\u6027\uff0c\u7eb3\u7c73\u6297\u4f53\u6bd4\u5c0f\u9f20mAbs\u8868\u73b0\u51fa\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e00\u4e2a\u6210\u719f\u7684\u8868\u9762\u5c55\u793a\u5e73\u53f0\u4e5f\u4fc3\u8fdb\u4e86\u80fd\u591f\u9488\u5bf9\u540c\u4e00\u6297\u539f\u7684\u4e0d\u540c\u8868\u4f4d\u7684\u591a\u4e2a\u7eb3\u7c73\u6297\u4f53\u7684\u751f\u6210\uff0c\u4f20\u7edfmAbs\u5728\u8fd9\u65b9\u9762\u901a\u5e38\u8868\u73b0\u51fa\u6bd4\u8f83\u6709\u9650\u7684\u80fd\u529b\u3002\u800c\u4e14\uff0c\u7279\u522b\u76f8\u5173\u7684\u662f\uff0c\u57fa\u4e8e\u7eb3\u7c73\u6297\u4f53\u7684CAR-T\u663e\u793a\u51fa\u589e\u5f3a\u7684\u6548\u5e94\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u3002\u6211\u4eec\u91c7\u7528\u4e86\u7eb3\u7c73\u6297\u4f53\u6280\u672f\u6765\u751f\u4ea7NS7CAR-T\u7ec6\u80de\u3002\u5728\u6b64\u6587\u7ae0\u4e2d\uff0c\u6211\u4eec\u62a5\u544a\u4e86Nanobody-based NS7CAR-T\u4ea7\u54c1\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\uff0c\u4ee5\u53ca\u5728\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d(https:\/\/clinicaltrials.gov NCT04938115)\u00a0 Nanobody-based NS7CAR-T\u6cbb\u7597\u96be\u6cbb\/\u590d\u53d1CD7\u9633\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7ed3\u679c\u3002 \u7814\u7a76\u65b9\u6cd5 \u57fa\u4e8e\u7eb3\u7c73\u6297\u4f53\u7684dVHH NS7CAR\u5305\u542b\u4e24\u4e2a\u6297CD7\u7eb3\u7c73\u6297\u4f53\uff08VHHs\uff09\u7684\u7f16\u7801\u533a\u57df\uff0c\u8fd9\u4e9b\u533a\u57df\u901a\u8fc7\u4e00\u4e2a\u8fde\u63a5\u5b50(G4S\uff095\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u4ee5\u53caCD8\u03b1\u94f0\u94fe\u533a\u57df\u3001CD8\u03b1\u8de8\u819c\u57df\uff0c\u8fd8\u6709\u4e00\u4e2a\u7b2c\u4e8c\u4ee3CAR\u7ec6\u80de\u9aa8\u67b6\uff0c\u5176\u5728\u7ec6\u80de\u5185\u5171\u523a\u6fc0\u57df\u5305\u542b4-1BB\u548cCD3\u03b6\u3002\u5236\u5907\u65f6\uff0c\u901a\u8fc7\u767d\u7ec6\u80de\u91c7\u96c6\u672f\u83b7\u5f97\u5916\u5468\u8840(PB)\u5355\u6838\u7ec6\u80de\uff0c\u5206\u79bbT\u7ec6\u80de\u5e76\u7528\u6162\u75c5\u6bd2\u8f6c\u5bfc\u3002\u7b2c\u4e8c\u4ee3CD7CAR\u7531\u6297CD7\u5355\u94fe\u6297\u4f53\u3001IgG4\u94f0\u94fe\u533a\u3001CD28TM\u8de8\u819c\u7ed3\u6784\u57df\u30014-1BB\u548cCD3\u03b6\u7684\u80de\u5185\u5171\u523a\u6fc0\u7ed3\u6784\u57df\u53ca\u622a\u77edEGFR\u86cb\u767d\u901a\u8fc7T2A\u8fde\u63a5\u6784\u6210\u3002\u6240\u6709\u60a3\u8005\u5728CD7CAR-T\u56de\u8f933\u5929\u524d\u9759\u6ce8\u6c1f\u8fbe\u62c9\u6ee8(30 mg\/m2\/d)\u548c\u73af\u78f7\u9170\u80fa(300 mg\/m2\/d)\u3002\u4ece\u91c7\u96c6\u5230CAR-T\u7ec6\u80de\u8f93\u6ce8\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a15\u5929\u3002 \u7814\u7a76\u7ed3\u679c \u9996\u5148\u662f\u4e34\u5e8a\u524d\u7814\u7a76\uff0cdVHH NS7CAR-T\u548c\u4f20\u7edfscFV NS7CAR\u7684\u7ed3\u6784\u5bf9\u6bd4\u3002\u7814\u7a76\u53d1\u73b0\uff0cdVHH NS7CAR-T\u7ec6\u80de\u5728\u57f9\u517b\u5927\u7ea6\u4e24\u5468\u540e\u663e\u793a\u51fa\u6bd4scFv NS7CAR-T\u66f4\u5f3a\u7684\u6269\u589e\u80fd\u529b\uff0823.9 folds vs.8.1 folds\uff0cP=0.024\uff09\u3002 \u5728\u4e0d\u540c\u7684\u6548\u5e94\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u6bd4\u4f8b\u4e0b\uff0cscFv\u548cdVHH NS7CAR-T\u7ec6\u80de\u5bf9KG1a\u9776\u7ec6\u80de\u8868\u73b0\u51fa\u76f8\u4f3c\u7684\u6297\u6076\u6027\u7ec6\u80de\u7684\u529f\u80fd\u3002\u6d41\u5f0f\u7ec6\u80de\u672f\uff08FCM\uff09\u3001\u9006\u8f6c\u5f55\u805a\u5408\u9176\u94fe\u53cd\u5e94\uff08RT-PCR\uff09\u548c\u86cb\u767d\u5370\u8ff9\uff08WB\uff09\u5206\u6790\u8868\u660e\uff0cscFv NS7CAR-T\u548cdVHH NS7CAR-T\u7ec6\u80de\u90fd\u6ca1\u6709\u5728\u5b83\u4eec\u7684\u7ec6\u80de\u8868\u9762\u68c0\u6d4b\u5230\u6d41\u5f0f\u7ec6\u80de\u672f\u53ef\u68c0\u6d4b\u7684CD7\u8868\u8fbe\uff0c\u7136\u800c\u901a\u8fc7RT-PCR\u548cWB\u68c0\u6d4b\u5230\u4e86\u663e\u8457\u7684CD7 mRNA\u548c\u86cb\u767d\u6c34\u5e73\u3002dVHH NS7CAR-T\u7ec6\u80de\u663e\u793a\u51fa\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5728\u8f93\u6ce8\u540e\u7b2c8\u5929\u8868\u73b0\u51fa\u663e\u8457\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u800c\u63a5\u53d7PBS\u6216\u5bf9\u7167T\u7ec6\u80de\u6cbb\u7597\u7684\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u8fc5\u901f\u3002 \u5728\u6b64I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5171\u5165\u7ec4\u4e8612\u4f8bCD7\u9633\u6027R\/R AML\uff08CD7\u8868\u8fbe\u7387&gt;50%\uff0c\u5f3a\u5ea6\u826f\u597d\uff09\uff0c\u6700\u540e10\u4f8b\u60a3\u8005\u63a5\u53d7\u4e86dVHH NS7CAR-T\u7ec6\u80de\u8f93\u6ce8\uff0c\u5176\u4e2d4\u4f8b\u8f93\u6ce8\u4e865\u00d7105\/kg\uff0c6\u4f8b\u8f93\u6ce8\u4e861\u00d7106\/kg\u3002\u4e2d\u4f4d\u5e74\u9f84\u4e3a34\u5c81\uff087-63\u5c81\uff09\uff0c\u5165\u7ec4\u65f6\u9aa8\u9ad3\u7684\u80bf\u7624\u8d1f\u8377\u4e2d\u4f4d\u503c\u4e3a17.0%\uff082.0-72.7%\uff09\u30021\u4f8b\u60a3\u8005\u540c\u65f6\u6709\u9ad3\u5916\u75c5\u53d8\uff08EMD\uff09\u3002\u5165\u7ec4\u524d\uff0c\u60a3\u8005\u66fe\u7ecf\u63a5\u53d7\u7684\u6cbb\u7597\u4e2d\u4f4d\u7ebf\u6570\u4e3a8\uff083-17\uff09\u3002\u800c\u4e14\uff0c7\u4f8b\u60a3\u8005\u6709\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u53f2\uff0c\u4ece\u4e0a\u6b21\u79fb\u690d\u5230\u590d\u53d1\u7684\u4e2d\u4f4d\u95f4\u9694\u671f\u4e3a12.5\u4e2a\u6708\uff083.5-19.5\u4e2a\u6708\uff09\u3002 \u5728dVHH NS7CAR-T\u7ec6\u80de\u8f93\u6ce8\u540e28\u5929\u8bc4\u4f30\uff0c7\/10\uff0870%\uff09\u60a3\u8005\u5728\u9aa8\u9ad3\u4e2d\u5b9e\u73b0\u4e86\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff0c\u5176\u4e2d6\u4eba\u8fbe\u5230\u4e86\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027CR\u30023\u4f8b\u60a3\u8005\u65e0\u6548\uff08NR\uff09\uff0c\u5176\u4e2d1\u4f8bEMD\u60a3\u8005\u6839\u636e\u7b2c35\u5929\u7684PET-CT\u8bc4\u4f30\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u3002\u6240\u6709NR\u60a3\u8005\u53d1\u73b0CD7\u6297\u539f\u4e22\u5931\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a\u4e3a178\u5929\uff0828-776\u5929\uff09\u3002\u5bf9\u4e8e7\u4f8bCR\u60a3\u8005\uff0c3\u4f8b\u5728CD7 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