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###<\/p>\n

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[1]Xiaoying Ma, Zhen Li, Lu Zhang,et al. Pegmolesatide Exhibits Sustained Erythropoiesis Stimulating Activity via EPOR-Mediated Signal Transduction – An Overview of Preclinical and Phase II Clinical Studies. Journal of Translational Medicine.In press.
[2]\u57f9\u83ab\u6c99\u80bd\u6ce8\u5c04\u6db2\u8bf4\u660e\u4e66\uff08\u4fee\u6539\u65e5\u671f\uff1a2024\u5e744\u67083\u65e5\uff09
[3]\u6307\u5bfc\u80be\u6027\u8d2b\u8840\u60a3\u8005\u81ea\u6211\u7ba1\u7406\u7684\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\u5de5\u4f5c\u7ec4. \u6307\u5bfc\u80be\u6027\u8d2b\u8840\u60a3\u8005\u81ea\u6211\u7ba1\u7406\u7684\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6(2024\u7248)[J]. \u4e2d\u56fd\u8840\u6db2\u51c0\u5316, 2025, 24(01): 1-12.
[4]EClinicalMedicine. 2023 Oct 28;65:102273.
[5] Kidney International Reports. Available online 6 December 2024. In Press. https:\/\/doi.org\/10.1016\/j.ekir.2024.12.002.<\/span><\/p>\n<\/div>\n

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### \u5173\u4e8e\u5723\u7f57\u83b1\u00ae \u5723\u7f57\u83b1\u00ae\u662f\u7ff0\u68ee\u5236\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684EPO\u6a21\u62df\u80bd\uff0c\u5df2\u4e8e2023\u5e746\u6708\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u900f\u6790\u548c\u975e\u900f\u6790\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u60a3\u8005\u8d2b\u8840\uff0c\u5e76\u4e8e\u5f53\u5e74\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u3002\u00a0 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Pegmolesatide Exhibits Sustained Erythropoiesis Stimulating Activity via EPOR-Mediated Signal Transduction – An Overview of Preclinical […]<\/p>\n","protected":false},"author":0,"featured_media":7814,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-7813","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\nJ Transl Med\uff5c\u7ff0\u68ee\u5236\u836f\u5723\u7f57\u83b1\u00ae\u957f\u6548\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u673a\u5236\u7814\u7a76\u53d1\u8868 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/j-transl-med\uff5c\u7ff0\u68ee\u5236\u836f\u5723\u7f57\u83b1\u957f\u6548\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u673a\u5236\u7814\u7a76\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"J Transl Med\uff5c\u7ff0\u68ee\u5236\u836f\u5723\u7f57\u83b1\u00ae\u957f\u6548\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u673a\u5236\u7814\u7a76\u53d1\u8868 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d772025\u5e742\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — 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science\u5b9e\u65f6\u5f71\u54cd\u56e0\u5b50\uff1a6.8\uff09\u53d1\u8868\u3002 \u4f5c\u4e3a\u4e00\u79cd\u957f\u6548\u5236\u5242\uff0c\u57f9\u83ab\u6c99\u80bd\u91c7\u7528\u7b2c\u4e09\u4ee3\u5206\u652f\u578b\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u4fee\u9970\u6280\u672f\uff0c\u80fd\u591f\u5927\u5927\u5ef6\u957f\u836f\u7269\u534a\u8870\u671f\uff0c\u5176\u5728\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u8d2b\u8840\u60a3\u8005\u4e2d\u7684\u6d88\u9664\u534a\u8870\u671f\uff08t1\/2\uff09\u4e3a58.3~74.9h[2]\u3002\u4e3a\u4e86\u9a8c\u8bc1\u9664\u534a\u8870\u671f\u5ef6\u957f\u4ee5\u5916\uff0c\u57f9\u83ab\u6c99\u80bd\u5f97\u4ee5\u5b9e\u73b0\u6bcf\u67081\u6b21\u7ed9\u836f\u7684\u957f\u6548\u673a\u5236\uff0c\u7814\u7a76\u8005\u4eec\u5f00\u5c55\u4e86\u591a\u9879\u7814\u7a76\u3002 \u672c\u6b21J Transl Med\u53d1\u8868\u7684\u957f\u6548\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u673a\u5236\u7814\u7a76\u5171\u6db5\u76d6\u4e00\u9879\u4f53\u5916\u8bd5\u9a8c\u3001\u4e00\u9879\u52a8\u7269\u8bd5\u9a8c\u53ca\u4e24\u9879\u5206\u522b\u9488\u5bf9\u900f\u6790\u548c\u975e\u900f\u6790CKD\u8d2b\u8840\u60a3\u8005\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c[1]\uff0c\u4ee5\u4e0b\u4e3a\u5177\u4f53\u7814\u7a76\u7ed3\u679c\u3002 \u4f53\u5916\u8bd5\u9a8c\uff1a\u57f9\u83ab\u6c99\u80bd\u4e0eEPO\u53d7\u4f53\u7684\u7ed3\u5408\u66f4\u7a33\u5b9a\u4e14\u6301\u4e45 \u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\uff08SPR\uff09\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4f20\u7edf\u7684\u77ed\u6548ESAs\u548c\u8fbe\u4f9d\u6cca\u6c40\u03b1\u76f8\u6bd4\uff0c\u57f9\u83ab\u6c99\u80bd\u4e0eEPOR\u7684\u7ed3\u5408\u66f4\u7a33\u5b9a\uff0c\u5e76\u4e14\u5728EPOR\u4e0a\u7684\u6ede\u7559\u65f6\u95f4\u66f4\u957f\uff0c\u7ea6\u4e3arHuEPO (ESPO 3000)\u76846.4\u500d\u3002\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u57f9\u83ab\u6c99\u80bd\u80fd\u591f\u4fc3\u8fdbUT-7\u7ec6\u80de\u589e\u6b96\uff0c\u7ef4\u6301\u7ec6\u80de\u5b58\u6d3b\u4ee5\u53ca\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\uff0c\u4e14\u6709\u52a9\u7ef4\u6301UT-7\u7ec6\u80de\u8868\u9762EPOR\u8868\u8fbe\uff0c\u8fdb\u800c\u6301\u7eed\u4fc3\u6210\u7ea2\u7ec6\u80de\u751f\u6210\u3002 \u8be5\u4f53\u5916\u7814\u7a76\u9996\u6b21\u9a8c\u8bc1\u4e86\u57f9\u83ab\u6c99\u80bd\u5728\u4f53\u5916\u4e0eEPO\u53d7\u4f53\uff08EPOR\uff09\u7684\u7ed3\u5408\u66f4\u7a33\u5b9a\u4e14\u6301\u4e45\uff0c\u5e76\u53ef\u901a\u8fc7\u7ef4\u6301\u7ec6\u80de\u8868\u9762EPOR\u7684\u8868\u8fbe\uff0c\u7ef4\u6301\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u6301\u7eed\u6fc0\u6d3b\u4ee5\u751f\u6210\u7ea2\u7ec6\u80de\uff0c\u4ece\u800c\u4e3a\u57f9\u83ab\u6c99\u80bd\u957f\u6548\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u4f5c\u7528\u63d0\u4f9b\u4e86\u6709\u529b\u7406\u8bba\u4f9d\u636e\u3002 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\u5065\u5eb7\u5c0f\u9f20\u4e2d\u5355\u6b21\u76ae\u4e0b\u6ce8\u5c04\u57f9\u83ab\u6c99\u80bd\u540e\u53d1\u73b0\uff0c\u5916\u5468\u7f51\u7ec7\u7ea2\u7ec6\u80de\u5728\u7b2c4\u5929\u663e\u8457\u589e\u52a0\uff0c\u7ea2\u7ec6\u80de\u3001\u8840\u7ea2\u86cb\u767d\u548c\u8840\u6bd4\u5bb9\u5728\u7b2c6\u5929\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u663e\u8457\u589e\u52a0\uff0c\u5e76\u6301\u7eed\u81f3\u7b2c14\u5929\u3002\u7531\u4e8e\u57f9\u83ab\u6c99\u80bd\u5728\u556e\u9f7f\u7c7b\u52a8\u7269\u4f53\u5185\u7684\u6e05\u9664\u901f\u5ea6\u8981\u6bd4\u5728\u4eba\u4f53\u4e2d\u5feb\u5f97\u591a\uff0c\u56e0\u6b64\uff0c\u8be5\u5b9e\u9a8c\u7ed3\u679c\u4e3a\u4eba\u4f53\u5185\u6bcf\u67081\u6b21\u7ed9\u836f\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e\u3002\u7814\u7a76\u8fd8\u663e\u793a\uff0c\u4e0e\u77ed\u6548ESA\uff08ESPO 3000\uff09\u76f8\u6bd4\uff0c\u57f9\u83ab\u6c99\u80bd\u5728\u5c0f\u9f20\u4f53\u5185\u8868\u73b0\u51fa\u66f4\u4e3a\u663e\u8457\u7684\u4fc3\u7ea2\u6548\u679c\u3002 \u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u57f9\u83ab\u6c99\u80bd\u5177\u6709PK-PD\u53cc\u5ef6\u957f\u6548\u5e94\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d \u5728\u4e24\u9879\u5206\u522b\u9488\u5bf9\u900f\u6790\u548c\u975e\u900f\u6790CKD\u8d2b\u8840\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u63a5\u53d7\u4e86\u4e0d\u540c\u5242\u91cf\uff080.025 mg\/kg\u30010.05 mg\/kg\u30010.08 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\u9664\u4e0a\u8ff0\u957f\u6548\u673a\u5236\u7814\u7a76\u5916\uff0c2025\u5e741\u6708\u53d1\u5e03\u7684\u300a\u6307\u5bfc\u80be\u6027\u8d2b\u8840\u60a3\u8005\u81ea\u6211\u7ba1\u7406\u7684\u4e2d\u56fd\u5171\u8bc6\uff082024\u7248\uff09\u300b\u4e2d\u63d0\u5230\uff0c\u76ee\u524d\u80be\u6027\u8d2b\u8840\u60a3\u8005\u7528\u836f\u4f9d\u4ece\u6027\u73b0\u72b6\u8f83\u5dee\uff0c\u53ef\u80fd\u4e0e\u5de5\u4f5c\u65f6\u95f4\u51b2\u7a81\u3001\u62c5\u5fc3\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3001\u836f\u4e38\u8f83\u5927\u541e\u54bd\u56f0\u96be\u3001\u6ce8\u5c04\u9891\u7387\u9ad8\u7b49\u539f\u56e0\u76f8\u5173\u3002\u800c\u5305\u62ecEPO\u6a21\u62df\u80bd\uff08\u57f9\u83ab\u6c99\u80bd\uff09\u7b49\u5728\u5185\u7684\u957f\u6548ESAs\uff0c\u53ef\u5ef6\u957f\u7528\u836f\u95f4\u9694\u3001\u51cf\u5c11\u7528\u836f\u6b21\u6570\uff0c\u63d0\u9ad8\u60a3\u8005\u6cbb\u7597\u4f9d\u4ece\u6027[3]\u3002\u56e0\u6b64\uff0c\u5723\u7f57\u83b1\u00ae\u7684\u957f\u6548\u673a\u5236\u5c06\u6709\u52a9\u4e8e\u63d0\u9ad8\u80be\u6027\u8d2b\u8840\u60a3\u8005\u7684\u4f9d\u4ece\u6027\u548c\u81ea\u6211\u7ba1\u7406\u6c34\u5e73\uff0c\u4fc3\u8fdb\u8840\u7ea2\u86cb\u767d\u8fbe\u6807\u548c\u6539\u5584\u60a3\u8005\u9884\u540e\u3002 ### \u5173\u4e8e\u5723\u7f57\u83b1\u00ae \u5723\u7f57\u83b1\u00ae\u662f\u7ff0\u68ee\u5236\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684EPO\u6a21\u62df\u80bd\uff0c\u5df2\u4e8e2023\u5e746\u6708\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u900f\u6790\u548c\u975e\u900f\u6790\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u60a3\u8005\u8d2b\u8840\uff0c\u5e76\u4e8e\u5f53\u5e74\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u3002\u00a0 \u4f5c\u4e3a\u4e00\u79cd\u957f\u6548\u5236\u5242\uff0c\u5723\u7f57\u83b1\u00ae\u4ec5\u9700\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f1\u6b21\uff0c\u5c31\u80fd\u591f\u5b9e\u73b0\u4e0d\u900a\u4e8e\u4f20\u7edf\u77ed\u6548ESAs\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027[4,5]\uff0c\u4e14\u76f8\u6bd4\u77ed\u6548ESAs\u9700\u8981\u9891\u7e41\u6ce8\u5c04\uff0c\u6bcf\u6708\u7ed9\u836f1\u6b21\u80fd\u591f\u5927\u5927\u63d0\u9ad8\u60a3\u8005\u7684\u6cbb\u7597\u4f9d\u4ece\u6027\uff0c\u5e2e\u52a9\u60a3\u8005\u51cf\u5c11\u5c31\u533b\u6b21\u6570\u548c\u82b1\u8d39\uff0c\u907f\u514d\u9891\u7e41\u6ce8\u5c04\u5e26\u6765\u7684\u75db\u82e6\uff0c\u6709\u52a9\u4e8e\u5b9e\u73b0\u80be\u6027\u8d2b\u8840\u7684\u957f\u671f\u7a33\u5b9a\u63a7\u5236\u3002 \u53c2\u8003\u6587\u732e\uff1a [1]Xiaoying Ma, Zhen Li, Lu Zhang,et al. Pegmolesatide Exhibits Sustained Erythropoiesis Stimulating Activity via EPOR-Mediated Signal Transduction – An Overview of Preclinical […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/moneycompass.com.my\/cn\/j-transl-med\uff5c\u7ff0\u68ee\u5236\u836f\u5723\u7f57\u83b1\u957f\u6548\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u673a\u5236\u7814\u7a76\/\" \/>\n<meta property=\"og:site_name\" content=\"Money Compass CN\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-27T09:41:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/02\/image_5009948_32975951-jCy9W2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"144\" \/>\n\t<meta property=\"og:image:height\" content=\"58\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" 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