{"id":8639,"date":"2025-03-19T02:17:00","date_gmt":"2025-03-19T02:17:00","guid":{"rendered":"http:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/"},"modified":"2025-03-19T02:17:00","modified_gmt":"2025-03-19T02:17:00","slug":"%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/","title":{"rendered":"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u65b0\u6cfd\u897f\u5dde<\/span><span class=\"legendSpanClass\">2025\u5e743\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0&#8221;<a href=\"https:\/\/www.hutch-med.com\/sc\/home\/\" target=\"_blank\" rel=\"noopener\">\u548c\u9ec4\u533b\u836f<\/a>&#8220;\u6216&#8221;HUTCHMED&#8221;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u548c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08Innovent Biologics, Inc.\uff0c\u7b80\u79f0&#8221;\u4fe1\u8fbe\u751f\u7269&#8221;\u6216&#8221;Innov<span>ent&#8221;\uff09\u4eca\u65e5<\/span>\u8054\u5408\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c\uff08fruquintinib\uff09\u548c\u4fe1\u8fea\u5229\u5355\u6297\uff08sintilimab\uff09\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u5df2\u8fbe\u5230\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u9605\u7247\uff08BICR\uff09\u6839\u636eRECIST 1.1\u6807\u51c6\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08&#8221;PFS&#8221;\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p>\n                        <a href=\"https:\/\/mma.prnewswire.com\/media\/1870188\/HUTCHMED_Logo_Logo.html\" target=\"_blank\" rel=\"noopener\"><\/a><\/p>\n<p>                        \n                <\/p>\n<\/div>\n<p>\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u8054\u5408\u7597\u6cd5\u65e9\u524d\u5df2\u57fa\u4e8eFRUSICA-1\u7814\u7a76\u7684\u6570\u636e\u53d6\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08&#8221;\u56fd\u5bb6\u836f\u76d1\u5c40&#8221;\uff09\u9644\u6761\u4ef6\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff08<a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT03903705\" target=\"_blank\" rel=\"noopener\">NCT03903705<\/a>\uff09\u3002<\/p>\n<p>FRUSICA-2\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\uff08axitinib\uff09\u6216\u4f9d\u7ef4\u83ab\u53f8\uff08everolimus\uff09\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05522231\" target=\"_blank\" rel=\"noopener\">NCT05522231<\/a>\uff09\u3002\u9664\u4e86\u4e3b\u8981\u7ec8\u70b9PFS\u5916\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u5728\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08&#8221;ORR&#8221;\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08&#8221;DoR&#8221;\uff09\u5728\u5185\u7684\u6b21\u8981\u7ec8\u70b9\u4e0a\u4ea6\u53d6\u5f97\u6539\u5584\u3002\u5b8c\u6574\u7684\u7814\u7a76\u6570\u636e\u5c06\u63d0\u4ea4\u4e8e\u8fd1\u671f\u7684\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002<\/p>\n<p>FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u53f6\u5b9a\u4f1f\u6559\u6388\u8868\u793a\uff1a&#8221;\u9776\u5411\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\u4ee5\u53ca\u5176\u8054\u5408\u7597\u6cd5\u65b9\u6848\u7684\u5feb\u901f\u53d1\u5c55\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u683c\u5c40\u5e26\u6765\u91cd\u5927\u53d8\u5316\u3002\u5728\u665a\u671f\u80be\u7ec6\u80de\u764c\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u9776\u5411\u6cbb\u7597\u4ecd\u7136\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u624b\u6bb5\u3002\u5bf9\u4e8e\u4e0d\u540c\u7684\u60a3\u8005\u4e2a\u4f53\uff0c\u5982\u4f55\u5408\u7406\u5730\u9009\u62e9\u9776\u5411\u6cbb\u7597\u6216\u9776\u514d\u8054\u5408\u6cbb\u7597\uff0c\u6210\u4e3a\u4e34\u5e8a\u5173\u6ce8\u7684\u70ed\u70b9\u3002FRUSICA-2 \u7814\u7a76\u7684\u7ed3\u679c\u51f8\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u8fd9\u79cd\u5177\u6709\u6311\u6218\u6027\u7684\u75be\u75c5\u60a3\u8005\u7684\u8feb\u5207\u533b\u7597\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\u3002&#8221;<\/p>\n<p>FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u4f55\u5fd7\u5d69\u6559\u6388\u8868\u793a\uff1a&#8221;\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u00a0III \u671f\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u662f\u665a\u671f\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u9886\u57df\u4e00\u9879\u91cd\u8981\u7684\u7a81\u7834\u3002\u6211\u4eec\u81f4\u529b\u4e3a\u5bf9\u73b0\u6709\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u7684\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6211\u4eec\u5bf9\u6b64\u9879\u53d1\u73b0\u53ef\u80fd\u4e3a\u4e34\u5e8a\u5b9e\u8df5\u5e26\u6765\u7684\u53d8\u9769\u5145\u6ee1\u4fe1\u5fc3\u3002&#8221;<\/p>\n<p>\u548c\u9ec4\u533b\u836f\u7814\u53d1\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u8be5\u7814\u7a76\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u63d0\u4f9b\u4e86\u660e\u786e\u7684\u8bc1\u636e\uff0c\u652f\u6301\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\u4e3a\u65e2\u5f80\u63a5\u53d7\u8fc7\u5176\u4ed6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002\u8fd9\u4e0d\u4ec5\u518d\u4e00\u6b21\u4f53\u73b0\u4e86\u6211\u4eec\u5bf9\u6539\u5584\u764c\u75c7\u6cbb\u7597\u7684\u627f\u8bfa\uff0c\u4e5f\u6807\u5fd7\u7740\u5728\u89e3\u51b3\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u65b9\u9762\u6240\u8fc8\u51fa\u7684\u91cd\u8981\u4e00\u6b65\u3002\u6211\u8877\u5fc3\u611f\u8c22\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\u7684\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u5bf9\u7814\u7a76\u7684\u6210\u529f\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u76d1\u7ba1\u673a\u6784\u5206\u4eab\u8be6\u7ec6\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u5c06\u5728\u672a\u6765\u51e0\u4e2a\u6708\u5185\u5bc6\u5207\u7b79\u5907\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002&#8221;<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a&#8221;\u6211\u4eec\u5bf9FRUSICA-2\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u611f\u5230\u5341\u5206\u9f13\u821e\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u4ec5\u7a81\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u4e5f\u4e3a\u7ecf\u6cbb\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u548c\u9ec4\u533b\u836f\u7d27\u5bc6\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u8be5\u521b\u65b0\u8054\u5408\u7597\u6cd5\u7684\u6ce8\u518c\u6c9f\u901a\uff0c\u5e76\u5c3d\u5feb\u9020\u798f\u60a3\u8005\u3002&#8221;<\/p>\n<p>\u5173\u4e8e\u80be\u764c\u53ca\u80be\u7ec6\u80de\u764c<br \/>2022\u5e74\u5168\u7403\u4f30\u8ba1\u7ea6\u65b0\u589e43.5\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[1]\u00a0\u5728\u4e2d\u56fd\uff0c2022\u5e74\u4f30\u8ba1\u65b0\u589e7.4\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[2]\u00a0\u5728\u6240\u6709\u80be\u764c\u75c5\u4f8b\u4e2d\uff0c\u80be\u7ec6\u80de\u764c\u7ea6\u536090%\u3002<\/p>\n<p>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c<br \/>\u544b\u55b9\u66ff\u5c3c\u662f\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;VEGFR&#8221;\uff09-1\u3001-2\u548c-3\u7684\u9009\u62e9\u6027\u53e3\u670d\u6291\u5236\u5242\u3002 VEGFR\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u544b\u55b9\u66ff\u5c3c\u88ab\u8bbe\u8ba1\u4e3a\u62e5\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9009\u62e9\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u8131\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u3001\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u8986\u76d6\u4ee5\u53ca\u5f53\u6f5c\u5728\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u65f6\u62e5\u6709\u66f4\u9ad8\u7684\u7075\u6d3b\u5ea6\u3002[3]<\/p>\n<p>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u83b7\u6279<br \/>\u5728\u4e2d\u56fd\uff0c\u544b\u55b9\u66ff\u5c3c\u7531\u548c\u9ec4\u533b\u836f\u53ca\u793c\u6765\u5236\u836f\u5408\u4f5c\u7814\u53d1\u548c\u9500\u552e\uff0c\u5e76\u4ee5\u5546\u54c1\u540d\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff09\u4e0a\u5e02\u3002\u544b\u55b9\u66ff\u5c3c\u5df2\u4e8e\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08&#8221;VEGF&#8221;\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;EGFR&#8221;\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002\u5176\u4e8e2020\u5e741\u6708\u83b7\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u81ea\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\u4ee5\u6765\u5df2\u60e0\u53ca\u8d85\u8fc710\u4e07\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002<\/p>\n<p>\u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\uff09\u548c\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u8054\u5408\u7597\u6cd5\u5df2\u4e8e\u4e2d\u56fd\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002<\/p>\n<p>\u6b66\u7530\u62e5\u6709\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u95e8\u4ee5\u5916\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u751f\u4ea7\u544b\u55b9\u66ff\u5c3c\u7684\u5168\u7403\u72ec\u5bb6\u8bb8\u53ef\uff0c\u5e76\u4ee5\u5546\u54c1\u540dFRUZAQLA\u00ae\u4e0a\u5e02\u9500\u552e\u3002\u544b\u55b9\u66ff\u5c3c\u4e8e2023\u5e7411\u6708<a href=\"https:\/\/www.hutch-med.com\/sc\/us-fda-approval-of-fruzaqla-fruquintinib\/\" target=\"_blank\" rel=\"noopener\">\u5728\u7f8e\u56fd<\/a>\u30012024\u5e746\u6708<a href=\"https:\/\/www.hutch-med.com\/sc\/european-commission-approval-for-fruzaqla-fruquintinib\/\" target=\"_blank\" rel=\"noopener\">\u5728\u6b27\u76df<\/a>\u30012024\u5e748\u6708\u5728\u745e\u58eb\u548c\u963f\u6839\u5ef7\u30012024\u5e749\u6708\u5728\u52a0\u62ff\u5927\u3001<a href=\"https:\/\/www.hutch-med.com\/sc\/japan-approval-for-fruzaqla-fruquintinib\/\" target=\"_blank\" rel=\"noopener\">\u65e5\u672c<\/a>\u548c\u82f1\u56fd\u30012024\u5e7410\u6708\u5728\u6fb3\u6d32\u548c\u65b0\u52a0\u5761\u3001\u4ee5\u53ca\u4e8e2024\u5e7412\u6708\u5728\u4ee5\u8272\u5217\u548c\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ecf\u6cbb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3002\u5728\u5176\u4ed6\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u76d1\u7ba1\u7533\u8bf7\u4ea6\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p>\u5411\u5168\u7403\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u7684\u6ce8\u518c\u7533\u8bf7\u662f\u57fa\u4e8e\u4e24\u9879\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u5927\u578b\u3001\u968f\u673a\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5373\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8cFRESCO-2\u7814\u7a76\u4ee5\u53ca\u4e8e\u4e2d\u56fd\u5f00\u5c55\u7684FRESCO\u7814\u7a76\uff0c\u5728\u603b\u5171734\u540d\u63a5\u53d7\u544b\u55b9\u66ff\u5c3c\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u4e86\u4e00\u81f4\u7684\u83b7\u76ca\u3002\u5404\u9879\u7814\u7a76\u7684\u5b89\u5168\u6027\u7279\u5f81\u4ea6\u4fdd\u6301\u4e00\u81f4\u3002FRESCO-2\u7814\u7a76\u7684\u7ed3\u679c\u5df2\u57282023\u5e746\u6708\u4e8e\u300a\u67f3\u53f6\u5200\uff08The Lancet\uff09\u300b<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(23)00772-9\/fulltext\" target=\"_blank\" rel=\"noopener\">\u53d1\u8868<\/a>\uff0c[4]\u00a0FRESCO\u7814\u7a76\u7684\u7ed3\u679c\u5219\u5df2\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\uff08JAMA\uff09\u300b\u4e0a<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2685988\" target=\"_blank\" rel=\"noopener\">\u53d1\u8868<\/a>\u3002[5]<\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4ee5\u4e0b\u7814\u7a76\u7528\u9014\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\u5c1a\u4e0d\u660e\u786e\uff0c\u4e0d\u80fd\u4fdd\u8bc1\u5176\u5c06\u5728\u4efb\u4f55\u56fd\u5bb6\u7684\u7814\u7a76\u7528\u9014\u80fd\u83b7\u5f97\u536b\u751f\u90e8\u95e8\u6279\u51c6\u6216\u5546\u4e1a\u4e0a\u5e02<\/p>\n<p>\u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u80be\u7ec6\u80de\u764c<br \/>\u7f8e\u56fd\u98df\u54c1\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u4e94\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u4f5c\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u7136\u800c\u73b0\u65f6\u4ec5\u6709\u4e00\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u57fa\u4e8e\u56fd\u9645\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u6570\u636e\u5e93\u8054\u76df \uff08IMDC\uff09\u6807\u51c6\u5212\u5206\u7684\u4e2d\u98ce\u9669\u6216\u9ad8\u98ce\u9669\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u76ee\u524d\u5355\u836f\u9776\u5411\u7597\u6cd5\u4ecd\u7136\u662f\u4e2d\u56fd\u665a\u671f\u80be\u7ec6\u80de\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u4e3b\u8981\u9009\u62e9\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u65e2\u5f80\u5355\u836f\u9776\u5411\u7597\u6cd5\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4ecd\u7136\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002<\/p>\n<p>\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u4e00\u9879Ib\/II\u671f\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u4e8e2025 \u5e74 1 \u6708\u5728\u300a\u9776\u5411\u80bf\u7624\u5b66\uff08Targeted Oncology\uff09\u300b\u671f\u520a\u53d1\u8868\u3002\u8be5\u8054\u5408\u7597\u6cd5\u5728\u6b64\u7c7b\u75be\u75c5\u4e2d\u5c55\u793a\u51fa\u4e86\u826f\u597d\u7684\u7597\u6548\u548c\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\u3002\u81f3\u6570\u636e\u622a\u6b62\u65e52024\u5e7410\u67089\u65e5\uff0c\u8be5\u7814\u7a76\u4e2d\u6240\u670920\u4f8b\u5165\u7ec4\u7684\u7ecf\u6cbb\u60a3\u8005\u5747\u53ef\u8bc4\u4f30\u7597\u6548\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a45.7\u4e2a\u6708\u3002\u786e\u8ba4\u7684ORR\u4e3a60.0%\uff0cDCR\u4e3a85.0%\u3002\u4e2d\u4f4dDoR\u4e3a13.9\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a15.9\u4e2a\u6708\u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c36\u4e2a\u6708\u7684OS\u7387\u4e3a58.3%\u3002[6]<\/p>\n<p>\u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297<br \/>\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u542f\u52a8\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684 \u3002[7]<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u5e76\u7eb3\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e03\u9879\u9002\u5e94\u75c7\uff0c\u534f\u8bae\u671f\u5185\u533b\u4fdd\u76ee\u5f55\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u8303\u56f4\u5305\u62ec\uff1a<\/p>\n<p>\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9634\u6027\u3001 \u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09 \u6cbb\u7597\u5931\u8d25\u7684 EGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff1b\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u516b\u9879\u9002\u5e94\u75c7\uff0c\u5373\u4e0e\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e2024\u5e7412\u6708\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u9644\u6761\u4ef6\u6279\u51c6\u3002\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u4e5d\u9879\u9002\u5e94\u75c7\uff0c\u5373\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u53ef\u5207\u9664\u7684\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u4f18\u5148\u5ba1\u8bc4\u4e2d\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a<\/p>\n<p>\u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u4fe1\u8fea\u5229\u5355\u6297\u548c\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\u6216\u4f9d\u7ef4\u83ab\u53f8\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684II\/III\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u58f0\u660e\uff1a\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/p>\n<p>\u5173\u4e8e\u548c\u9ec4\u533b\u836f<br \/>\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7b49\u5168\u7403\u5404\u5730\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1a<a href=\"https:\/\/www.hutch-med.com\/sc\" target=\"_blank\" rel=\"noopener\">www.hutch\u2011med.com<\/a>\u6216\u5173\u6ce8\u6211\u4eec\u7684<a href=\"https:\/\/www.linkedin.com\/company\/hutchmed\/\" target=\"_blank\" rel=\"noopener\">\u9886\u82f1<\/a>\u4e13\u9875\u3002<\/p>\n<p>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<br \/>&#8220;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&#8221;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\uff0c\u8ba9\u6211\u4eec\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u4fe1\u8fbe\u751f\u7269\u5df2\u670915\u4e2a\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u4eec\u5206\u522b\u662f\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u8212\u00ae\uff09\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u6538\u540c\u00ae\uff09\uff0c\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82cf\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u534e\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u8fbe\u4f2f\u5766\u00ae\uff09\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u62e9\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u80f6\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\uff0c\u6258\u83b1\u897f\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u4e50\u00ae\uff09, \u6c1f\u6cfd\u96f7\u585e\u7247\uff08\u8fbe\u4f2f\u7279\u00ae\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247(\u6377\u5e15\u529b\u00ae)\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u80f6\u56ca\uff08\u8fbe\u4f2f\u4e50\u00ae\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5965\u58f9\u65b0\u00ae\uff09\u548c\u66ff\u59a5\u5c24\u5355\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u65f6\u8fd8\u67093\u4e2a\u54c1\u79cd\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u8bc4\u4e2d\uff0c3\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670916\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u591a\u9879\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u81ea\u7814\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u79c9\u627f\u7ecf\u6d4e\u5efa\u8bbe\u4ee5\u4eba\u6c11\u4e3a\u4e2d\u5fc3\u7684\u53d1\u5c55\u601d\u60f3\u3002\u591a\u5e74\u6765\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88\u4ee5&#8221;\u60a3\u8005\u4e3a\u4e2d\u5fc3&#8221;\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u4fe1\u8fbe\u751f\u7269\u9646\u7eed\u53d1\u8d77\u3001\u53c2\u4e0e\u4e86\u591a\u9879\u836f\u54c1\u516c\u76ca\u63f4\u52a9\u9879\u76ee\uff0c\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u591f\u5f97\u76ca\u4e8e\u751f\u547d\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u4e70\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8d28\u91cf\u7684\u751f\u7269\u836f\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u8fbe\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9879\u76ee\u5df2\u60e0\u53ca20\u4f59\u4e07\u666e\u901a\u60a3\u8005\uff0c\u836f\u7269\u6350\u8d60\u603b\u4ef7\u503c36\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u4fe1\u8fbe\u751f\u7269\u7f51\u7ad9\uff1a <a href=\"https:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"noopener\">www.innoventbio.com<\/a> \u6216\u4fe1\u8fbe\u751f\u7269\u9886\u82f1\u8d26\u53f7<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p>\u58f0\u660e\uff1a1.\u4fe1\u8fbe\u751f\u7269\u4e0d\u63a8\u8350\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u7684\u4f7f\u7528\u3002<br \/>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a02.\u96f7\u83ab\u897f\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u62e9\u00ae\uff09\u3001\u585e\u666e\u66ff\u5c3c\u80f6\u56ca\uff08\u777f\u59a5\u00ae\uff09\u548c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247\uff08\u6377\u5e15\u529b\u00ae\uff09\u7531\u793c\u6765\u5236\u836f\u7814\u53d1<\/p>\n<div class=\"wcag-arialevel-3\">\u524d\u77bb\u6027\u9648\u8ff0<\/div>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b1995\u5e74\u300a\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b&#8221;\u5b89\u5168\u6e2f&#8221;\u6761\u6b3e\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\u53cd\u6620\u4e86\u548c\u9ec4\u533b\u836f\u76ee\u524d\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u9884\u671f\uff0c\u5305\u62ec\u5bf9\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6f5c\u529b\u7684\u9884\u671f\uff0c\u4ee5\u53ca\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u9488\u5bf9\u6b64\u9002\u5e94\u75c7\u53ca\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u3002\u524d\u77bb\u6027\u9648\u8ff0\u6d89\u53ca\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u6b64\u7c7b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4e0b\u5217\u5047\u8bbe\uff1a\u652f\u6301\u544b\u55b9\u66ff\u5c3c\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5728\u4e2d\u56fd\u6216\u5176\u4ed6\u5730\u533a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u7684\u6570\u636e\u5145\u8db3\u6027\u3001\u544b\u55b9\u66ff\u5c3c\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3001\u548c\u9ec4\u533b\u836f\u4e3a\u544b\u55b9\u66ff\u5c3c\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u53ca\u5546\u4e1a\u5316\u63d0\u4f9b\u8d44\u91d1\u5e76\u5b9e\u73b0\u53ca\u5b8c\u6210\u7684\u80fd\u529b\uff0c\u4ee5\u53ca\u6b64\u7c7b\u4e8b\u4ef6\u53d1\u751f\u7684\u65f6\u95f4\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u90e8\u5206\u7814\u7a76\u8d56\u4e8e\u628a\u5176\u4ed6\u836f\u7269\u4ea7\u54c1\uff08\u5982\u4fe1\u8fea\u5229\u5355\u6297\uff09\u4e0e\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4f7f\u7528\uff0c\u56e0\u6b64\u6b64\u7c7b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u6709\u5173\u8fd9\u4e9b\u6cbb\u7597\u836f\u7269\u7684\u5b89\u5168\u6027\u3001\u7597\u6548\u3001\u4f9b\u5e94\u548c\u76d1\u7ba1\u6279\u51c6\u7684\u5047\u8bbe\u3002\u5f53\u524d\u548c\u6f5c\u5728\u6295\u8d44\u8005\u8bf7\u52ff\u8fc7\u5ea6\u4f9d\u8d56\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u8fd9\u4e9b\u9648\u8ff0\u4ec5\u5728\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u5f53\u65e5\u6709\u6548\u3002\u6709\u5173\u8fd9\u4e9b\u98ce\u9669\u548c\u5176\u4ed6\u98ce\u9669\u7684\u8fdb\u4e00\u6b65\u8ba8\u8bba\uff0c\u8bf7\u67e5\u9605\u548c\u9ec4\u533b\u836f\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u3001\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4ee5\u53caAIM\u63d0\u4ea4\u7684\u6587\u4ef6\u3002\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8baf\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u60c5\u51b5\u6216\u5176\u4ed6\u56e0\u7d20\uff0c\u548c\u9ec4\u533b\u836f\u5747\u4e0d\u627f\u62c5\u66f4\u65b0\u6216\u4fee\u8ba2\u672c\u65b0\u95fb\u7a3f\u6240\u542b\u8baf\u606f\u7684\u4e49\u52a1\u3002<\/p>\n<div class=\"wcag-arialevel-3\">\u533b\u7597\u4fe1\u606f<\/div>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u63d0\u5230\u7684\u4ea7\u54c1\u53ef\u80fd\u5e76\u672a\u5728\u6240\u6709\u56fd\u5bb6\u4e0a\u5e02\uff0c\u6216\u53ef\u80fd\u4ee5\u4e0d\u540c\u7684\u5546\u6807\u8fdb\u884c\u9500\u552e\uff0c\u6216\u7528\u4e8e\u4e0d\u540c\u7684\u75c5\u75c7\uff0c\u6216\u91c7\u7528\u4e0d\u540c\u7684\u5242\u91cf\uff0c\u6216\u62e5\u6709\u4e0d\u540c\u7684\u6548\u529b\u3002\u672c\u6587\u4e2d\u6240\u5305\u542b\u7684\u4efb\u4f55\u4fe1\u606f\u90fd\u4e0d\u5e94\u88ab\u770b\u4f5c\u662f\u4efb\u4f55\u5904\u65b9\u836f\u7684\u7533\u8bf7\u3001\u63a8\u5e7f\u6216\u5e7f\u544a\uff0c\u5305\u62ec\u90a3\u4e9b\u6b63\u5728\u7814\u53d1\u7684\u836f\u7269\u3002<\/p>\n\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u00a0\u00a0 The Global Cancer Observatory, kidney cancer fact sheet. <a class=\"prnews_a\" href=\"https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/29-kidney-fact-sheet.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/29-kidney-fact-sheet.pdf<\/a>. Accessed February 19, 2025.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] \u00a0\u00a0 The Global Cancer Observatory, China fact sheet. <a class=\"prnews_a\" href=\"https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf<\/a>. Accessed February 19, 2025.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] \u00a0\u00a0 Sun Q, et al. Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45. doi: 10.4161\/15384047.2014.964087.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]\u00a0\u00a0\u00a0 Dasari NA, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO\u20112): an international, multicentre, randomised, double\u2011blind, Phase III study. Lancet. 2023;402(10395):41\u201153. doi:10.1016\/S0140\u20116736(23)00772\u20119.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]\u00a0\u00a0\u00a0 Li J, et al. Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial. JAMA. 2018;319(24):2486-2496. DOI:10.1001\/jama.2018.7855.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[6]\u00a0\u00a0\u00a0 Xu H, et al. Fruquintinib Plus Sintilimab in Patients with Treatment\u2011Na\u00efve and Previously Treated Advanced Renal Cell Carcinoma: Results from a Phase Ib\/II Clinical Trial. Targeted Oncology. 2025; 20:113\u2013125. doi.org\/10.1007\/s11523-024-01120-6.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[7]\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. doi: 10.1080\/19420862.2019.1654303.<\/span><\/p>\n<\/div>\n<p>SOURCE  \u548c\u9ec4\u533b\u836f(\u4e2d\u56fd)\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u65b0\u6cfd\u897f\u5dde2025\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0&#8221;\u548c\u9ec4\u533b\u836f&#8220;\u6216&#8221;HUTCHMED&#8221;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u548c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08Innovent Biologics, Inc.\uff0c\u7b80\u79f0&#8221;\u4fe1\u8fbe\u751f\u7269&#8221;\u6216&#8221;Innovent&#8221;\uff09\u4eca\u65e5\u8054\u5408\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c\uff08fruquintinib\uff09\u548c\u4fe1\u8fea\u5229\u5355\u6297\uff08sintilimab\uff09\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u5df2\u8fbe\u5230\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u9605\u7247\uff08BICR\uff09\u6839\u636eRECIST 1.1\u6807\u51c6\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08&#8221;PFS&#8221;\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002 \u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u8054\u5408\u7597\u6cd5\u65e9\u524d\u5df2\u57fa\u4e8eFRUSICA-1\u7814\u7a76\u7684\u6570\u636e\u53d6\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08&#8221;\u56fd\u5bb6\u836f\u76d1\u5c40&#8221;\uff09\u9644\u6761\u4ef6\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff08NCT03903705\uff09\u3002 FRUSICA-2\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\uff08axitinib\uff09\u6216\u4f9d\u7ef4\u83ab\u53f8\uff08everolimus\uff09\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff08NCT05522231\uff09\u3002\u9664\u4e86\u4e3b\u8981\u7ec8\u70b9PFS\u5916\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u5728\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08&#8221;ORR&#8221;\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08&#8221;DoR&#8221;\uff09\u5728\u5185\u7684\u6b21\u8981\u7ec8\u70b9\u4e0a\u4ea6\u53d6\u5f97\u6539\u5584\u3002\u5b8c\u6574\u7684\u7814\u7a76\u6570\u636e\u5c06\u63d0\u4ea4\u4e8e\u8fd1\u671f\u7684\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002 FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u53f6\u5b9a\u4f1f\u6559\u6388\u8868\u793a\uff1a&#8221;\u9776\u5411\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\u4ee5\u53ca\u5176\u8054\u5408\u7597\u6cd5\u65b9\u6848\u7684\u5feb\u901f\u53d1\u5c55\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u683c\u5c40\u5e26\u6765\u91cd\u5927\u53d8\u5316\u3002\u5728\u665a\u671f\u80be\u7ec6\u80de\u764c\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u9776\u5411\u6cbb\u7597\u4ecd\u7136\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u624b\u6bb5\u3002\u5bf9\u4e8e\u4e0d\u540c\u7684\u60a3\u8005\u4e2a\u4f53\uff0c\u5982\u4f55\u5408\u7406\u5730\u9009\u62e9\u9776\u5411\u6cbb\u7597\u6216\u9776\u514d\u8054\u5408\u6cbb\u7597\uff0c\u6210\u4e3a\u4e34\u5e8a\u5173\u6ce8\u7684\u70ed\u70b9\u3002FRUSICA-2 \u7814\u7a76\u7684\u7ed3\u679c\u51f8\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u8fd9\u79cd\u5177\u6709\u6311\u6218\u6027\u7684\u75be\u75c5\u60a3\u8005\u7684\u8feb\u5207\u533b\u7597\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\u3002&#8221; FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u4f55\u5fd7\u5d69\u6559\u6388\u8868\u793a\uff1a&#8221;\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u00a0III \u671f\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u662f\u665a\u671f\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u9886\u57df\u4e00\u9879\u91cd\u8981\u7684\u7a81\u7834\u3002\u6211\u4eec\u81f4\u529b\u4e3a\u5bf9\u73b0\u6709\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u7684\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6211\u4eec\u5bf9\u6b64\u9879\u53d1\u73b0\u53ef\u80fd\u4e3a\u4e34\u5e8a\u5b9e\u8df5\u5e26\u6765\u7684\u53d8\u9769\u5145\u6ee1\u4fe1\u5fc3\u3002&#8221; \u548c\u9ec4\u533b\u836f\u7814\u53d1\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u8be5\u7814\u7a76\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u63d0\u4f9b\u4e86\u660e\u786e\u7684\u8bc1\u636e\uff0c\u652f\u6301\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\u4e3a\u65e2\u5f80\u63a5\u53d7\u8fc7\u5176\u4ed6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002\u8fd9\u4e0d\u4ec5\u518d\u4e00\u6b21\u4f53\u73b0\u4e86\u6211\u4eec\u5bf9\u6539\u5584\u764c\u75c7\u6cbb\u7597\u7684\u627f\u8bfa\uff0c\u4e5f\u6807\u5fd7\u7740\u5728\u89e3\u51b3\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u65b9\u9762\u6240\u8fc8\u51fa\u7684\u91cd\u8981\u4e00\u6b65\u3002\u6211\u8877\u5fc3\u611f\u8c22\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\u7684\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u5bf9\u7814\u7a76\u7684\u6210\u529f\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u76d1\u7ba1\u673a\u6784\u5206\u4eab\u8be6\u7ec6\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u5c06\u5728\u672a\u6765\u51e0\u4e2a\u6708\u5185\u5bc6\u5207\u7b79\u5907\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002&#8221; \u4fe1\u8fbe\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a&#8221;\u6211\u4eec\u5bf9FRUSICA-2\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u611f\u5230\u5341\u5206\u9f13\u821e\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u4ec5\u7a81\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u4e5f\u4e3a\u7ecf\u6cbb\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u548c\u9ec4\u533b\u836f\u7d27\u5bc6\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u8be5\u521b\u65b0\u8054\u5408\u7597\u6cd5\u7684\u6ce8\u518c\u6c9f\u901a\uff0c\u5e76\u5c3d\u5feb\u9020\u798f\u60a3\u8005\u3002&#8221; \u5173\u4e8e\u80be\u764c\u53ca\u80be\u7ec6\u80de\u764c2022\u5e74\u5168\u7403\u4f30\u8ba1\u7ea6\u65b0\u589e43.5\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[1]\u00a0\u5728\u4e2d\u56fd\uff0c2022\u5e74\u4f30\u8ba1\u65b0\u589e7.4\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[2]\u00a0\u5728\u6240\u6709\u80be\u764c\u75c5\u4f8b\u4e2d\uff0c\u80be\u7ec6\u80de\u764c\u7ea6\u536090%\u3002 \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u544b\u55b9\u66ff\u5c3c\u662f\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;VEGFR&#8221;\uff09-1\u3001-2\u548c-3\u7684\u9009\u62e9\u6027\u53e3\u670d\u6291\u5236\u5242\u3002 VEGFR\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u544b\u55b9\u66ff\u5c3c\u88ab\u8bbe\u8ba1\u4e3a\u62e5\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9009\u62e9\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u8131\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u3001\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u8986\u76d6\u4ee5\u53ca\u5f53\u6f5c\u5728\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u65f6\u62e5\u6709\u66f4\u9ad8\u7684\u7075\u6d3b\u5ea6\u3002[3] \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u83b7\u6279\u5728\u4e2d\u56fd\uff0c\u544b\u55b9\u66ff\u5c3c\u7531\u548c\u9ec4\u533b\u836f\u53ca\u793c\u6765\u5236\u836f\u5408\u4f5c\u7814\u53d1\u548c\u9500\u552e\uff0c\u5e76\u4ee5\u5546\u54c1\u540d\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff09\u4e0a\u5e02\u3002\u544b\u55b9\u66ff\u5c3c\u5df2\u4e8e\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08&#8221;VEGF&#8221;\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;EGFR&#8221;\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002\u5176\u4e8e2020\u5e741\u6708\u83b7\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u81ea\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\u4ee5\u6765\u5df2\u60e0\u53ca\u8d85\u8fc710\u4e07\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002 \u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\uff09\u548c\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u8054\u5408\u7597\u6cd5\u5df2\u4e8e\u4e2d\u56fd\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002 \u6b66\u7530\u62e5\u6709\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u95e8\u4ee5\u5916\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u751f\u4ea7\u544b\u55b9\u66ff\u5c3c\u7684\u5168\u7403\u72ec\u5bb6\u8bb8\u53ef\uff0c\u5e76\u4ee5\u5546\u54c1\u540dFRUZAQLA\u00ae\u4e0a\u5e02\u9500\u552e\u3002\u544b\u55b9\u66ff\u5c3c\u4e8e2023\u5e7411\u6708\u5728\u7f8e\u56fd\u30012024\u5e746\u6708\u5728\u6b27\u76df\u30012024\u5e748\u6708\u5728\u745e\u58eb\u548c\u963f\u6839\u5ef7\u30012024\u5e749\u6708\u5728\u52a0\u62ff\u5927\u3001\u65e5\u672c\u548c\u82f1\u56fd\u30012024\u5e7410\u6708\u5728\u6fb3\u6d32\u548c\u65b0\u52a0\u5761\u3001\u4ee5\u53ca\u4e8e2024\u5e7412\u6708\u5728\u4ee5\u8272\u5217\u548c\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ecf\u6cbb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3002\u5728\u5176\u4ed6\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u76d1\u7ba1\u7533\u8bf7\u4ea6\u5728\u8fdb\u884c\u4e2d\u3002 \u5411\u5168\u7403\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u7684\u6ce8\u518c\u7533\u8bf7\u662f\u57fa\u4e8e\u4e24\u9879\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u5927\u578b\u3001\u968f\u673a\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5373\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8cFRESCO-2\u7814\u7a76\u4ee5\u53ca\u4e8e\u4e2d\u56fd\u5f00\u5c55\u7684FRESCO\u7814\u7a76\uff0c\u5728\u603b\u5171734\u540d\u63a5\u53d7\u544b\u55b9\u66ff\u5c3c\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u4e86\u4e00\u81f4\u7684\u83b7\u76ca\u3002\u5404\u9879\u7814\u7a76\u7684\u5b89\u5168\u6027\u7279\u5f81\u4ea6\u4fdd\u6301\u4e00\u81f4\u3002FRESCO-2\u7814\u7a76\u7684\u7ed3\u679c\u5df2\u57282023\u5e746\u6708\u4e8e\u300a\u67f3\u53f6\u5200\uff08The Lancet\uff09\u300b\u53d1\u8868\uff0c[4]\u00a0FRESCO\u7814\u7a76\u7684\u7ed3\u679c\u5219\u5df2\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\uff08JAMA\uff09\u300b\u4e0a\u53d1\u8868\u3002[5] \u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4ee5\u4e0b\u7814\u7a76\u7528\u9014\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\u5c1a\u4e0d\u660e\u786e\uff0c\u4e0d\u80fd\u4fdd\u8bc1\u5176\u5c06\u5728\u4efb\u4f55\u56fd\u5bb6\u7684\u7814\u7a76\u7528\u9014\u80fd\u83b7\u5f97\u536b\u751f\u90e8\u95e8\u6279\u51c6\u6216\u5546\u4e1a\u4e0a\u5e02 \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u7f8e\u56fd\u98df\u54c1\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u4e94\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u4f5c\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u7136\u800c\u73b0\u65f6\u4ec5\u6709\u4e00\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u57fa\u4e8e\u56fd\u9645\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u6570\u636e\u5e93\u8054\u76df \uff08IMDC\uff09\u6807\u51c6\u5212\u5206\u7684\u4e2d\u98ce\u9669\u6216\u9ad8\u98ce\u9669\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u76ee\u524d\u5355\u836f\u9776\u5411\u7597\u6cd5\u4ecd\u7136\u662f\u4e2d\u56fd\u665a\u671f\u80be\u7ec6\u80de\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u4e3b\u8981\u9009\u62e9\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u65e2\u5f80\u5355\u836f\u9776\u5411\u7597\u6cd5\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4ecd\u7136\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002 \u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u4e00\u9879Ib\/II\u671f\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u4e8e2025 \u5e74 1 \u6708\u5728\u300a\u9776\u5411\u80bf\u7624\u5b66\uff08Targeted Oncology\uff09\u300b\u671f\u520a\u53d1\u8868\u3002\u8be5\u8054\u5408\u7597\u6cd5\u5728\u6b64\u7c7b\u75be\u75c5\u4e2d\u5c55\u793a\u51fa\u4e86\u826f\u597d\u7684\u7597\u6548\u548c\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\u3002\u81f3\u6570\u636e\u622a\u6b62\u65e52024\u5e7410\u67089\u65e5\uff0c\u8be5\u7814\u7a76\u4e2d\u6240\u670920\u4f8b\u5165\u7ec4\u7684\u7ecf\u6cbb\u60a3\u8005\u5747\u53ef\u8bc4\u4f30\u7597\u6548\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a45.7\u4e2a\u6708\u3002\u786e\u8ba4\u7684ORR\u4e3a60.0%\uff0cDCR\u4e3a85.0%\u3002\u4e2d\u4f4dDoR\u4e3a13.9\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a15.9\u4e2a\u6708\u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c36\u4e2a\u6708\u7684OS\u7387\u4e3a58.3%\u3002[6] \u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u542f\u52a8\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684 \u3002[7] \u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u5e76\u7eb3\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e03\u9879\u9002\u5e94\u75c7\uff0c\u534f\u8bae\u671f\u5185\u533b\u4fdd\u76ee\u5f55\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u8303\u56f4\u5305\u62ec\uff1a \u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9634\u6027\u3001 \u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09 \u6cbb\u7597\u5931\u8d25\u7684 EGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff1b\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002 \u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u516b\u9879\u9002\u5e94\u75c7\uff0c\u5373\u4e0e\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e2024\u5e7412\u6708\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u9644\u6761\u4ef6\u6279\u51c6\u3002\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u4e5d\u9879\u9002\u5e94\u75c7\uff0c\u5373\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u53ef\u5207\u9664\u7684\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u4f18\u5148\u5ba1\u8bc4\u4e2d\u3002 \u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a \u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u4fe1\u8fea\u5229\u5355\u6297\u548c\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\u6216\u4f9d\u7ef4\u83ab\u53f8\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684II\/III\u671f\u4e34\u5e8a\u7814\u7a76\u3002 \u58f0\u660e\uff1a\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002 \u5173\u4e8e\u548c\u9ec4\u533b\u836f\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7b49\u5168\u7403\u5404\u5730\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1awww.hutch\u2011med.com\u6216\u5173\u6ce8\u6211\u4eec\u7684\u9886\u82f1\u4e13\u9875\u3002 \u5173\u4e8e\u4fe1\u8fbe\u751f\u7269&#8220;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&#8221;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\uff0c\u8ba9\u6211\u4eec\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u4fe1\u8fbe\u751f\u7269\u5df2\u670915\u4e2a\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u4eec\u5206\u522b\u662f\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u8212\u00ae\uff09\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u6538\u540c\u00ae\uff09\uff0c\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82cf\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u534e\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u8fbe\u4f2f\u5766\u00ae\uff09\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u62e9\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u80f6\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\uff0c\u6258\u83b1\u897f\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u4e50\u00ae\uff09, \u6c1f\u6cfd\u96f7\u585e\u7247\uff08\u8fbe\u4f2f\u7279\u00ae\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247(\u6377\u5e15\u529b\u00ae)\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u80f6\u56ca\uff08\u8fbe\u4f2f\u4e50\u00ae\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5965\u58f9\u65b0\u00ae\uff09\u548c\u66ff\u59a5\u5c24\u5355\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u65f6\u8fd8\u67093\u4e2a\u54c1\u79cd\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u8bc4\u4e2d\uff0c3\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670916\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002 \u4fe1\u8fbe\u751f\u7269\u5df2\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u591a\u9879\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u81ea\u7814\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u79c9\u627f\u7ecf\u6d4e\u5efa\u8bbe\u4ee5\u4eba\u6c11\u4e3a\u4e2d\u5fc3\u7684\u53d1\u5c55\u601d\u60f3\u3002\u591a\u5e74\u6765\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88\u4ee5&#8221;\u60a3\u8005\u4e3a\u4e2d\u5fc3&#8221;\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u4fe1\u8fbe\u751f\u7269\u9646\u7eed\u53d1\u8d77\u3001\u53c2\u4e0e\u4e86\u591a\u9879\u836f\u54c1\u516c\u76ca\u63f4\u52a9\u9879\u76ee\uff0c\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u591f\u5f97\u76ca\u4e8e\u751f\u547d\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u4e70\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8d28\u91cf\u7684\u751f\u7269\u836f\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u8fbe\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9879\u76ee\u5df2\u60e0\u53ca20\u4f59\u4e07\u666e\u901a\u60a3\u8005\uff0c\u836f\u7269\u6350\u8d60\u603b\u4ef7\u503c36\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u4fe1\u8fbe\u751f\u7269\u7f51\u7ad9\uff1a www.innoventbio.com [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":8640,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-8639","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c-fruquintinib-\u8054\u5408\u4fe1\u8fea\u5229\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"\u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u65b0\u6cfd\u897f\u5dde2025\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0&#8221;\u548c\u9ec4\u533b\u836f&#8220;\u6216&#8221;HUTCHMED&#8221;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u548c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08Innovent Biologics, Inc.\uff0c\u7b80\u79f0&#8221;\u4fe1\u8fbe\u751f\u7269&#8221;\u6216&#8221;Innovent&#8221;\uff09\u4eca\u65e5\u8054\u5408\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c\uff08fruquintinib\uff09\u548c\u4fe1\u8fea\u5229\u5355\u6297\uff08sintilimab\uff09\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u5df2\u8fbe\u5230\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u9605\u7247\uff08BICR\uff09\u6839\u636eRECIST 1.1\u6807\u51c6\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08&#8221;PFS&#8221;\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002 \u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u8054\u5408\u7597\u6cd5\u65e9\u524d\u5df2\u57fa\u4e8eFRUSICA-1\u7814\u7a76\u7684\u6570\u636e\u53d6\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08&#8221;\u56fd\u5bb6\u836f\u76d1\u5c40&#8221;\uff09\u9644\u6761\u4ef6\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff08NCT03903705\uff09\u3002 FRUSICA-2\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\uff08axitinib\uff09\u6216\u4f9d\u7ef4\u83ab\u53f8\uff08everolimus\uff09\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff08NCT05522231\uff09\u3002\u9664\u4e86\u4e3b\u8981\u7ec8\u70b9PFS\u5916\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u5728\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08&#8221;ORR&#8221;\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08&#8221;DoR&#8221;\uff09\u5728\u5185\u7684\u6b21\u8981\u7ec8\u70b9\u4e0a\u4ea6\u53d6\u5f97\u6539\u5584\u3002\u5b8c\u6574\u7684\u7814\u7a76\u6570\u636e\u5c06\u63d0\u4ea4\u4e8e\u8fd1\u671f\u7684\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002 FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u53f6\u5b9a\u4f1f\u6559\u6388\u8868\u793a\uff1a&#8221;\u9776\u5411\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\u4ee5\u53ca\u5176\u8054\u5408\u7597\u6cd5\u65b9\u6848\u7684\u5feb\u901f\u53d1\u5c55\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u683c\u5c40\u5e26\u6765\u91cd\u5927\u53d8\u5316\u3002\u5728\u665a\u671f\u80be\u7ec6\u80de\u764c\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u9776\u5411\u6cbb\u7597\u4ecd\u7136\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u624b\u6bb5\u3002\u5bf9\u4e8e\u4e0d\u540c\u7684\u60a3\u8005\u4e2a\u4f53\uff0c\u5982\u4f55\u5408\u7406\u5730\u9009\u62e9\u9776\u5411\u6cbb\u7597\u6216\u9776\u514d\u8054\u5408\u6cbb\u7597\uff0c\u6210\u4e3a\u4e34\u5e8a\u5173\u6ce8\u7684\u70ed\u70b9\u3002FRUSICA-2 \u7814\u7a76\u7684\u7ed3\u679c\u51f8\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u8fd9\u79cd\u5177\u6709\u6311\u6218\u6027\u7684\u75be\u75c5\u60a3\u8005\u7684\u8feb\u5207\u533b\u7597\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\u3002&#8221; FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u4f55\u5fd7\u5d69\u6559\u6388\u8868\u793a\uff1a&#8221;\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u00a0III \u671f\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u662f\u665a\u671f\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u9886\u57df\u4e00\u9879\u91cd\u8981\u7684\u7a81\u7834\u3002\u6211\u4eec\u81f4\u529b\u4e3a\u5bf9\u73b0\u6709\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u7684\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6211\u4eec\u5bf9\u6b64\u9879\u53d1\u73b0\u53ef\u80fd\u4e3a\u4e34\u5e8a\u5b9e\u8df5\u5e26\u6765\u7684\u53d8\u9769\u5145\u6ee1\u4fe1\u5fc3\u3002&#8221; \u548c\u9ec4\u533b\u836f\u7814\u53d1\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u8be5\u7814\u7a76\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u63d0\u4f9b\u4e86\u660e\u786e\u7684\u8bc1\u636e\uff0c\u652f\u6301\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\u4e3a\u65e2\u5f80\u63a5\u53d7\u8fc7\u5176\u4ed6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002\u8fd9\u4e0d\u4ec5\u518d\u4e00\u6b21\u4f53\u73b0\u4e86\u6211\u4eec\u5bf9\u6539\u5584\u764c\u75c7\u6cbb\u7597\u7684\u627f\u8bfa\uff0c\u4e5f\u6807\u5fd7\u7740\u5728\u89e3\u51b3\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u65b9\u9762\u6240\u8fc8\u51fa\u7684\u91cd\u8981\u4e00\u6b65\u3002\u6211\u8877\u5fc3\u611f\u8c22\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\u7684\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u5bf9\u7814\u7a76\u7684\u6210\u529f\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u76d1\u7ba1\u673a\u6784\u5206\u4eab\u8be6\u7ec6\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u5c06\u5728\u672a\u6765\u51e0\u4e2a\u6708\u5185\u5bc6\u5207\u7b79\u5907\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002&#8221; \u4fe1\u8fbe\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a&#8221;\u6211\u4eec\u5bf9FRUSICA-2\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u611f\u5230\u5341\u5206\u9f13\u821e\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u4ec5\u7a81\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u4e5f\u4e3a\u7ecf\u6cbb\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u548c\u9ec4\u533b\u836f\u7d27\u5bc6\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u8be5\u521b\u65b0\u8054\u5408\u7597\u6cd5\u7684\u6ce8\u518c\u6c9f\u901a\uff0c\u5e76\u5c3d\u5feb\u9020\u798f\u60a3\u8005\u3002&#8221; \u5173\u4e8e\u80be\u764c\u53ca\u80be\u7ec6\u80de\u764c2022\u5e74\u5168\u7403\u4f30\u8ba1\u7ea6\u65b0\u589e43.5\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[1]\u00a0\u5728\u4e2d\u56fd\uff0c2022\u5e74\u4f30\u8ba1\u65b0\u589e7.4\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[2]\u00a0\u5728\u6240\u6709\u80be\u764c\u75c5\u4f8b\u4e2d\uff0c\u80be\u7ec6\u80de\u764c\u7ea6\u536090%\u3002 \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u544b\u55b9\u66ff\u5c3c\u662f\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;VEGFR&#8221;\uff09-1\u3001-2\u548c-3\u7684\u9009\u62e9\u6027\u53e3\u670d\u6291\u5236\u5242\u3002 VEGFR\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u544b\u55b9\u66ff\u5c3c\u88ab\u8bbe\u8ba1\u4e3a\u62e5\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9009\u62e9\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u8131\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u3001\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u8986\u76d6\u4ee5\u53ca\u5f53\u6f5c\u5728\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u65f6\u62e5\u6709\u66f4\u9ad8\u7684\u7075\u6d3b\u5ea6\u3002[3] \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u83b7\u6279\u5728\u4e2d\u56fd\uff0c\u544b\u55b9\u66ff\u5c3c\u7531\u548c\u9ec4\u533b\u836f\u53ca\u793c\u6765\u5236\u836f\u5408\u4f5c\u7814\u53d1\u548c\u9500\u552e\uff0c\u5e76\u4ee5\u5546\u54c1\u540d\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff09\u4e0a\u5e02\u3002\u544b\u55b9\u66ff\u5c3c\u5df2\u4e8e\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08&#8221;VEGF&#8221;\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;EGFR&#8221;\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002\u5176\u4e8e2020\u5e741\u6708\u83b7\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u81ea\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\u4ee5\u6765\u5df2\u60e0\u53ca\u8d85\u8fc710\u4e07\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002 \u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\uff09\u548c\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u8054\u5408\u7597\u6cd5\u5df2\u4e8e\u4e2d\u56fd\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002 \u6b66\u7530\u62e5\u6709\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u95e8\u4ee5\u5916\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u751f\u4ea7\u544b\u55b9\u66ff\u5c3c\u7684\u5168\u7403\u72ec\u5bb6\u8bb8\u53ef\uff0c\u5e76\u4ee5\u5546\u54c1\u540dFRUZAQLA\u00ae\u4e0a\u5e02\u9500\u552e\u3002\u544b\u55b9\u66ff\u5c3c\u4e8e2023\u5e7411\u6708\u5728\u7f8e\u56fd\u30012024\u5e746\u6708\u5728\u6b27\u76df\u30012024\u5e748\u6708\u5728\u745e\u58eb\u548c\u963f\u6839\u5ef7\u30012024\u5e749\u6708\u5728\u52a0\u62ff\u5927\u3001\u65e5\u672c\u548c\u82f1\u56fd\u30012024\u5e7410\u6708\u5728\u6fb3\u6d32\u548c\u65b0\u52a0\u5761\u3001\u4ee5\u53ca\u4e8e2024\u5e7412\u6708\u5728\u4ee5\u8272\u5217\u548c\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ecf\u6cbb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3002\u5728\u5176\u4ed6\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u76d1\u7ba1\u7533\u8bf7\u4ea6\u5728\u8fdb\u884c\u4e2d\u3002 \u5411\u5168\u7403\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u7684\u6ce8\u518c\u7533\u8bf7\u662f\u57fa\u4e8e\u4e24\u9879\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u5927\u578b\u3001\u968f\u673a\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5373\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8cFRESCO-2\u7814\u7a76\u4ee5\u53ca\u4e8e\u4e2d\u56fd\u5f00\u5c55\u7684FRESCO\u7814\u7a76\uff0c\u5728\u603b\u5171734\u540d\u63a5\u53d7\u544b\u55b9\u66ff\u5c3c\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u4e86\u4e00\u81f4\u7684\u83b7\u76ca\u3002\u5404\u9879\u7814\u7a76\u7684\u5b89\u5168\u6027\u7279\u5f81\u4ea6\u4fdd\u6301\u4e00\u81f4\u3002FRESCO-2\u7814\u7a76\u7684\u7ed3\u679c\u5df2\u57282023\u5e746\u6708\u4e8e\u300a\u67f3\u53f6\u5200\uff08The Lancet\uff09\u300b\u53d1\u8868\uff0c[4]\u00a0FRESCO\u7814\u7a76\u7684\u7ed3\u679c\u5219\u5df2\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\uff08JAMA\uff09\u300b\u4e0a\u53d1\u8868\u3002[5] \u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4ee5\u4e0b\u7814\u7a76\u7528\u9014\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\u5c1a\u4e0d\u660e\u786e\uff0c\u4e0d\u80fd\u4fdd\u8bc1\u5176\u5c06\u5728\u4efb\u4f55\u56fd\u5bb6\u7684\u7814\u7a76\u7528\u9014\u80fd\u83b7\u5f97\u536b\u751f\u90e8\u95e8\u6279\u51c6\u6216\u5546\u4e1a\u4e0a\u5e02 \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u7f8e\u56fd\u98df\u54c1\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u4e94\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u4f5c\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u7136\u800c\u73b0\u65f6\u4ec5\u6709\u4e00\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u57fa\u4e8e\u56fd\u9645\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u6570\u636e\u5e93\u8054\u76df \uff08IMDC\uff09\u6807\u51c6\u5212\u5206\u7684\u4e2d\u98ce\u9669\u6216\u9ad8\u98ce\u9669\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u76ee\u524d\u5355\u836f\u9776\u5411\u7597\u6cd5\u4ecd\u7136\u662f\u4e2d\u56fd\u665a\u671f\u80be\u7ec6\u80de\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u4e3b\u8981\u9009\u62e9\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u65e2\u5f80\u5355\u836f\u9776\u5411\u7597\u6cd5\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4ecd\u7136\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002 \u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u4e00\u9879Ib\/II\u671f\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u4e8e2025 \u5e74 1 \u6708\u5728\u300a\u9776\u5411\u80bf\u7624\u5b66\uff08Targeted Oncology\uff09\u300b\u671f\u520a\u53d1\u8868\u3002\u8be5\u8054\u5408\u7597\u6cd5\u5728\u6b64\u7c7b\u75be\u75c5\u4e2d\u5c55\u793a\u51fa\u4e86\u826f\u597d\u7684\u7597\u6548\u548c\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\u3002\u81f3\u6570\u636e\u622a\u6b62\u65e52024\u5e7410\u67089\u65e5\uff0c\u8be5\u7814\u7a76\u4e2d\u6240\u670920\u4f8b\u5165\u7ec4\u7684\u7ecf\u6cbb\u60a3\u8005\u5747\u53ef\u8bc4\u4f30\u7597\u6548\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a45.7\u4e2a\u6708\u3002\u786e\u8ba4\u7684ORR\u4e3a60.0%\uff0cDCR\u4e3a85.0%\u3002\u4e2d\u4f4dDoR\u4e3a13.9\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a15.9\u4e2a\u6708\u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c36\u4e2a\u6708\u7684OS\u7387\u4e3a58.3%\u3002[6] \u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u542f\u52a8\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684 \u3002[7] \u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u5e76\u7eb3\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e03\u9879\u9002\u5e94\u75c7\uff0c\u534f\u8bae\u671f\u5185\u533b\u4fdd\u76ee\u5f55\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u8303\u56f4\u5305\u62ec\uff1a \u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9634\u6027\u3001 \u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09 \u6cbb\u7597\u5931\u8d25\u7684 EGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff1b\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002 \u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u516b\u9879\u9002\u5e94\u75c7\uff0c\u5373\u4e0e\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e2024\u5e7412\u6708\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u9644\u6761\u4ef6\u6279\u51c6\u3002\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u4e5d\u9879\u9002\u5e94\u75c7\uff0c\u5373\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u53ef\u5207\u9664\u7684\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u4f18\u5148\u5ba1\u8bc4\u4e2d\u3002 \u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a \u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u4fe1\u8fea\u5229\u5355\u6297\u548c\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\u6216\u4f9d\u7ef4\u83ab\u53f8\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684II\/III\u671f\u4e34\u5e8a\u7814\u7a76\u3002 \u58f0\u660e\uff1a\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002 \u5173\u4e8e\u548c\u9ec4\u533b\u836f\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7b49\u5168\u7403\u5404\u5730\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1awww.hutch\u2011med.com\u6216\u5173\u6ce8\u6211\u4eec\u7684\u9886\u82f1\u4e13\u9875\u3002 \u5173\u4e8e\u4fe1\u8fbe\u751f\u7269&#8220;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&#8221;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\uff0c\u8ba9\u6211\u4eec\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u4fe1\u8fbe\u751f\u7269\u5df2\u670915\u4e2a\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u4eec\u5206\u522b\u662f\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u8212\u00ae\uff09\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u6538\u540c\u00ae\uff09\uff0c\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82cf\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u534e\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u8fbe\u4f2f\u5766\u00ae\uff09\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u62e9\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u80f6\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\uff0c\u6258\u83b1\u897f\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u4e50\u00ae\uff09, \u6c1f\u6cfd\u96f7\u585e\u7247\uff08\u8fbe\u4f2f\u7279\u00ae\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247(\u6377\u5e15\u529b\u00ae)\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u80f6\u56ca\uff08\u8fbe\u4f2f\u4e50\u00ae\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5965\u58f9\u65b0\u00ae\uff09\u548c\u66ff\u59a5\u5c24\u5355\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u65f6\u8fd8\u67093\u4e2a\u54c1\u79cd\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u8bc4\u4e2d\uff0c3\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670916\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002 \u4fe1\u8fbe\u751f\u7269\u5df2\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u591a\u9879\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u81ea\u7814\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u79c9\u627f\u7ecf\u6d4e\u5efa\u8bbe\u4ee5\u4eba\u6c11\u4e3a\u4e2d\u5fc3\u7684\u53d1\u5c55\u601d\u60f3\u3002\u591a\u5e74\u6765\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88\u4ee5&#8221;\u60a3\u8005\u4e3a\u4e2d\u5fc3&#8221;\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u4fe1\u8fbe\u751f\u7269\u9646\u7eed\u53d1\u8d77\u3001\u53c2\u4e0e\u4e86\u591a\u9879\u836f\u54c1\u516c\u76ca\u63f4\u52a9\u9879\u76ee\uff0c\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u591f\u5f97\u76ca\u4e8e\u751f\u547d\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u4e70\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8d28\u91cf\u7684\u751f\u7269\u836f\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u8fbe\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9879\u76ee\u5df2\u60e0\u53ca20\u4f59\u4e07\u666e\u901a\u60a3\u8005\uff0c\u836f\u7269\u6350\u8d60\u603b\u4ef7\u503c36\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u4fe1\u8fbe\u751f\u7269\u7f51\u7ad9\uff1a www.innoventbio.com [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c-fruquintinib-\u8054\u5408\u4fe1\u8fea\u5229\/\" \/>\n<meta property=\"og:site_name\" content=\"Money Compass CN\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-19T02:17:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"144\" \/>\n\t<meta property=\"og:image:height\" content=\"41\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/\",\"name\":\"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9 - Money Compass CN\",\"isPartOf\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg\",\"datePublished\":\"2025-03-19T02:17:00+00:00\",\"dateModified\":\"2025-03-19T02:17:00+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#primaryimage\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg\",\"contentUrl\":\"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg\",\"width\":144,\"height\":41},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/moneycompass.com.my\/cn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/moneycompass.com.my\/cn\/#website\",\"url\":\"https:\/\/moneycompass.com.my\/cn\/\",\"name\":\"Money Compass CN\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9 - Money Compass CN","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c-fruquintinib-\u8054\u5408\u4fe1\u8fea\u5229\/","og_locale":"en_US","og_type":"article","og_title":"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9 - Money Compass CN","og_description":"\u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u65b0\u6cfd\u897f\u5dde2025\u5e743\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0&#8221;\u548c\u9ec4\u533b\u836f&#8220;\u6216&#8221;HUTCHMED&#8221;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u548c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08Innovent Biologics, Inc.\uff0c\u7b80\u79f0&#8221;\u4fe1\u8fbe\u751f\u7269&#8221;\u6216&#8221;Innovent&#8221;\uff09\u4eca\u65e5\u8054\u5408\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c\uff08fruquintinib\uff09\u548c\u4fe1\u8fea\u5229\u5355\u6297\uff08sintilimab\uff09\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u5df2\u8fbe\u5230\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u9605\u7247\uff08BICR\uff09\u6839\u636eRECIST 1.1\u6807\u51c6\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08&#8221;PFS&#8221;\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002 \u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u8054\u5408\u7597\u6cd5\u65e9\u524d\u5df2\u57fa\u4e8eFRUSICA-1\u7814\u7a76\u7684\u6570\u636e\u53d6\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08&#8221;\u56fd\u5bb6\u836f\u76d1\u5c40&#8221;\uff09\u9644\u6761\u4ef6\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff08NCT03903705\uff09\u3002 FRUSICA-2\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\uff08axitinib\uff09\u6216\u4f9d\u7ef4\u83ab\u53f8\uff08everolimus\uff09\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff08NCT05522231\uff09\u3002\u9664\u4e86\u4e3b\u8981\u7ec8\u70b9PFS\u5916\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u5728\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08&#8221;ORR&#8221;\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08&#8221;DoR&#8221;\uff09\u5728\u5185\u7684\u6b21\u8981\u7ec8\u70b9\u4e0a\u4ea6\u53d6\u5f97\u6539\u5584\u3002\u5b8c\u6574\u7684\u7814\u7a76\u6570\u636e\u5c06\u63d0\u4ea4\u4e8e\u8fd1\u671f\u7684\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002 FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u53f6\u5b9a\u4f1f\u6559\u6388\u8868\u793a\uff1a&#8221;\u9776\u5411\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\u4ee5\u53ca\u5176\u8054\u5408\u7597\u6cd5\u65b9\u6848\u7684\u5feb\u901f\u53d1\u5c55\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u683c\u5c40\u5e26\u6765\u91cd\u5927\u53d8\u5316\u3002\u5728\u665a\u671f\u80be\u7ec6\u80de\u764c\u7cfb\u7edf\u6027\u6cbb\u7597\u4e2d\uff0c\u9776\u5411\u6cbb\u7597\u4ecd\u7136\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u624b\u6bb5\u3002\u5bf9\u4e8e\u4e0d\u540c\u7684\u60a3\u8005\u4e2a\u4f53\uff0c\u5982\u4f55\u5408\u7406\u5730\u9009\u62e9\u9776\u5411\u6cbb\u7597\u6216\u9776\u514d\u8054\u5408\u6cbb\u7597\uff0c\u6210\u4e3a\u4e34\u5e8a\u5173\u6ce8\u7684\u70ed\u70b9\u3002FRUSICA-2 \u7814\u7a76\u7684\u7ed3\u679c\u51f8\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5728\u89e3\u51b3\u8fd9\u79cd\u5177\u6709\u6311\u6218\u6027\u7684\u75be\u75c5\u60a3\u8005\u7684\u8feb\u5207\u533b\u7597\u9700\u6c42\u65b9\u9762\u7684\u6f5c\u529b\u3002&#8221; FRUSICA-2\u7814\u7a76\u7684\u8054\u5408\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u4f55\u5fd7\u5d69\u6559\u6388\u8868\u793a\uff1a&#8221;\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u00a0III \u671f\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u662f\u665a\u671f\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u9886\u57df\u4e00\u9879\u91cd\u8981\u7684\u7a81\u7834\u3002\u6211\u4eec\u81f4\u529b\u4e3a\u5bf9\u73b0\u6709\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u7684\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6211\u4eec\u5bf9\u6b64\u9879\u53d1\u73b0\u53ef\u80fd\u4e3a\u4e34\u5e8a\u5b9e\u8df5\u5e26\u6765\u7684\u53d8\u9769\u5145\u6ee1\u4fe1\u5fc3\u3002&#8221; \u548c\u9ec4\u533b\u836f\u7814\u53d1\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb\u8868\u793a\uff1a&#8221;\u8be5\u7814\u7a76\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u63d0\u4f9b\u4e86\u660e\u786e\u7684\u8bc1\u636e\uff0c\u652f\u6301\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\u4e3a\u65e2\u5f80\u63a5\u53d7\u8fc7\u5176\u4ed6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6709\u6548\u6cbb\u7597\u9009\u62e9\u3002\u8fd9\u4e0d\u4ec5\u518d\u4e00\u6b21\u4f53\u73b0\u4e86\u6211\u4eec\u5bf9\u6539\u5584\u764c\u75c7\u6cbb\u7597\u7684\u627f\u8bfa\uff0c\u4e5f\u6807\u5fd7\u7740\u5728\u89e3\u51b3\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u65b9\u9762\u6240\u8fc8\u51fa\u7684\u91cd\u8981\u4e00\u6b65\u3002\u6211\u8877\u5fc3\u611f\u8c22\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\u7684\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u5bf9\u7814\u7a76\u7684\u6210\u529f\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u76d1\u7ba1\u673a\u6784\u5206\u4eab\u8be6\u7ec6\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u5c06\u5728\u672a\u6765\u51e0\u4e2a\u6708\u5185\u5bc6\u5207\u7b79\u5907\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002&#8221; \u4fe1\u8fbe\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a&#8221;\u6211\u4eec\u5bf9FRUSICA-2\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u611f\u5230\u5341\u5206\u9f13\u821e\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u4ec5\u7a81\u663e\u4e86\u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u4e5f\u4e3a\u7ecf\u6cbb\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u548c\u9ec4\u533b\u836f\u7d27\u5bc6\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u8be5\u521b\u65b0\u8054\u5408\u7597\u6cd5\u7684\u6ce8\u518c\u6c9f\u901a\uff0c\u5e76\u5c3d\u5feb\u9020\u798f\u60a3\u8005\u3002&#8221; \u5173\u4e8e\u80be\u764c\u53ca\u80be\u7ec6\u80de\u764c2022\u5e74\u5168\u7403\u4f30\u8ba1\u7ea6\u65b0\u589e43.5\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[1]\u00a0\u5728\u4e2d\u56fd\uff0c2022\u5e74\u4f30\u8ba1\u65b0\u589e7.4\u4e07\u4f8b\u80be\u764c\u60a3\u8005\u3002[2]\u00a0\u5728\u6240\u6709\u80be\u764c\u75c5\u4f8b\u4e2d\uff0c\u80be\u7ec6\u80de\u764c\u7ea6\u536090%\u3002 \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u544b\u55b9\u66ff\u5c3c\u662f\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;VEGFR&#8221;\uff09-1\u3001-2\u548c-3\u7684\u9009\u62e9\u6027\u53e3\u670d\u6291\u5236\u5242\u3002 VEGFR\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u544b\u55b9\u66ff\u5c3c\u88ab\u8bbe\u8ba1\u4e3a\u62e5\u6709\u66f4\u9ad8\u7684\u6fc0\u9176\u9009\u62e9\u6027\uff0c\u65e8\u5728\u964d\u4f4e\u8131\u9776\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u3001\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u8986\u76d6\u4ee5\u53ca\u5f53\u6f5c\u5728\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u65f6\u62e5\u6709\u66f4\u9ad8\u7684\u7075\u6d3b\u5ea6\u3002[3] \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u83b7\u6279\u5728\u4e2d\u56fd\uff0c\u544b\u55b9\u66ff\u5c3c\u7531\u548c\u9ec4\u533b\u836f\u53ca\u793c\u6765\u5236\u836f\u5408\u4f5c\u7814\u53d1\u548c\u9500\u552e\uff0c\u5e76\u4ee5\u5546\u54c1\u540d\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff09\u4e0a\u5e02\u3002\u544b\u55b9\u66ff\u5c3c\u5df2\u4e8e\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08&#8221;VEGF&#8221;\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&#8221;EGFR&#8221;\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002\u5176\u4e8e2020\u5e741\u6708\u83b7\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u81ea\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\u4ee5\u6765\u5df2\u60e0\u53ca\u8d85\u8fc710\u4e07\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002 \u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\uff09\u548c\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u8054\u5408\u7597\u6cd5\u5df2\u4e8e\u4e2d\u56fd\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002 \u6b66\u7530\u62e5\u6709\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u548c\u6fb3\u95e8\u4ee5\u5916\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u548c\u751f\u4ea7\u544b\u55b9\u66ff\u5c3c\u7684\u5168\u7403\u72ec\u5bb6\u8bb8\u53ef\uff0c\u5e76\u4ee5\u5546\u54c1\u540dFRUZAQLA\u00ae\u4e0a\u5e02\u9500\u552e\u3002\u544b\u55b9\u66ff\u5c3c\u4e8e2023\u5e7411\u6708\u5728\u7f8e\u56fd\u30012024\u5e746\u6708\u5728\u6b27\u76df\u30012024\u5e748\u6708\u5728\u745e\u58eb\u548c\u963f\u6839\u5ef7\u30012024\u5e749\u6708\u5728\u52a0\u62ff\u5927\u3001\u65e5\u672c\u548c\u82f1\u56fd\u30012024\u5e7410\u6708\u5728\u6fb3\u6d32\u548c\u65b0\u52a0\u5761\u3001\u4ee5\u53ca\u4e8e2024\u5e7412\u6708\u5728\u4ee5\u8272\u5217\u548c\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7ecf\u6cbb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3002\u5728\u5176\u4ed6\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u76d1\u7ba1\u7533\u8bf7\u4ea6\u5728\u8fdb\u884c\u4e2d\u3002 \u5411\u5168\u7403\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u7684\u6ce8\u518c\u7533\u8bf7\u662f\u57fa\u4e8e\u4e24\u9879\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u5927\u578b\u3001\u968f\u673a\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5373\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8cFRESCO-2\u7814\u7a76\u4ee5\u53ca\u4e8e\u4e2d\u56fd\u5f00\u5c55\u7684FRESCO\u7814\u7a76\uff0c\u5728\u603b\u5171734\u540d\u63a5\u53d7\u544b\u55b9\u66ff\u5c3c\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u4e86\u4e00\u81f4\u7684\u83b7\u76ca\u3002\u5404\u9879\u7814\u7a76\u7684\u5b89\u5168\u6027\u7279\u5f81\u4ea6\u4fdd\u6301\u4e00\u81f4\u3002FRESCO-2\u7814\u7a76\u7684\u7ed3\u679c\u5df2\u57282023\u5e746\u6708\u4e8e\u300a\u67f3\u53f6\u5200\uff08The Lancet\uff09\u300b\u53d1\u8868\uff0c[4]\u00a0FRESCO\u7814\u7a76\u7684\u7ed3\u679c\u5219\u5df2\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\uff08JAMA\uff09\u300b\u4e0a\u53d1\u8868\u3002[5] \u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4ee5\u4e0b\u7814\u7a76\u7528\u9014\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\u5c1a\u4e0d\u660e\u786e\uff0c\u4e0d\u80fd\u4fdd\u8bc1\u5176\u5c06\u5728\u4efb\u4f55\u56fd\u5bb6\u7684\u7814\u7a76\u7528\u9014\u80fd\u83b7\u5f97\u536b\u751f\u90e8\u95e8\u6279\u51c6\u6216\u5546\u4e1a\u4e0a\u5e02 \u5173\u4e8e\u544b\u55b9\u66ff\u5c3c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u7f8e\u56fd\u98df\u54c1\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u4e94\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u4f5c\u4e3a\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u7136\u800c\u73b0\u65f6\u4ec5\u6709\u4e00\u79cd\u514d\u75ab\u80bf\u7624\u8054\u5408\u7597\u6cd5\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u57fa\u4e8e\u56fd\u9645\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u6570\u636e\u5e93\u8054\u76df \uff08IMDC\uff09\u6807\u51c6\u5212\u5206\u7684\u4e2d\u98ce\u9669\u6216\u9ad8\u98ce\u9669\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u76ee\u524d\u5355\u836f\u9776\u5411\u7597\u6cd5\u4ecd\u7136\u662f\u4e2d\u56fd\u665a\u671f\u80be\u7ec6\u80de\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u4e3b\u8981\u9009\u62e9\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u65e2\u5f80\u5355\u836f\u9776\u5411\u7597\u6cd5\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4ecd\u7136\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002 \u544b\u55b9\u66ff\u5c3c\u548c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u4e00\u9879Ib\/II\u671f\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u4e8e2025 \u5e74 1 \u6708\u5728\u300a\u9776\u5411\u80bf\u7624\u5b66\uff08Targeted Oncology\uff09\u300b\u671f\u520a\u53d1\u8868\u3002\u8be5\u8054\u5408\u7597\u6cd5\u5728\u6b64\u7c7b\u75be\u75c5\u4e2d\u5c55\u793a\u51fa\u4e86\u826f\u597d\u7684\u7597\u6548\u548c\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\u3002\u81f3\u6570\u636e\u622a\u6b62\u65e52024\u5e7410\u67089\u65e5\uff0c\u8be5\u7814\u7a76\u4e2d\u6240\u670920\u4f8b\u5165\u7ec4\u7684\u7ecf\u6cbb\u60a3\u8005\u5747\u53ef\u8bc4\u4f30\u7597\u6548\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a45.7\u4e2a\u6708\u3002\u786e\u8ba4\u7684ORR\u4e3a60.0%\uff0cDCR\u4e3a85.0%\u3002\u4e2d\u4f4dDoR\u4e3a13.9\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a15.9\u4e2a\u6708\u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c36\u4e2a\u6708\u7684OS\u7387\u4e3a58.3%\u3002[6] \u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u542f\u52a8\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684 \u3002[7] \u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u5e76\u7eb3\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e03\u9879\u9002\u5e94\u75c7\uff0c\u534f\u8bae\u671f\u5185\u533b\u4fdd\u76ee\u5f55\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u8303\u56f4\u5305\u62ec\uff1a \u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9634\u6027\u3001 \u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09 \u6cbb\u7597\u5931\u8d25\u7684 EGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff1b\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002 \u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u516b\u9879\u9002\u5e94\u75c7\uff0c\u5373\u4e0e\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u6cbb\u7597\u540e\u5931\u8d25\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u6839\u6cbb\u6027\u624b\u672f\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u653e\u7597\u7684\u665a\u671f\u9519\u914d\u4fee\u590d\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e2024\u5e7412\u6708\u53d6\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u9644\u6761\u4ef6\u6279\u51c6\u3002\u4fe1\u8fea\u5229\u5355\u6297\u7684\u7b2c\u4e5d\u9879\u9002\u5e94\u75c7\uff0c\u5373\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u53ef\u5207\u9664\u7684\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u4f18\u5148\u5ba1\u8bc4\u4e2d\u3002 \u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a \u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u4fe1\u8fea\u5229\u5355\u6297\u548c\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u963f\u6614\u66ff\u5c3c\u6216\u4f9d\u7ef4\u83ab\u53f8\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684II\/III\u671f\u4e34\u5e8a\u7814\u7a76\u3002 \u58f0\u660e\uff1a\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002 \u5173\u4e8e\u548c\u9ec4\u533b\u836f\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7b49\u5168\u7403\u5404\u5730\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1awww.hutch\u2011med.com\u6216\u5173\u6ce8\u6211\u4eec\u7684\u9886\u82f1\u4e13\u9875\u3002 \u5173\u4e8e\u4fe1\u8fbe\u751f\u7269&#8220;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&#8221;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\uff0c\u8ba9\u6211\u4eec\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u4fe1\u8fbe\u751f\u7269\u5df2\u670915\u4e2a\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u4eec\u5206\u522b\u662f\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u8212\u00ae\uff09\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u6538\u540c\u00ae\uff09\uff0c\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82cf\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u534e\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u8fbe\u4f2f\u5766\u00ae\uff09\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u62e9\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u80f6\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf\u00ae\uff09\uff0c\u6258\u83b1\u897f\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u4e50\u00ae\uff09, \u6c1f\u6cfd\u96f7\u585e\u7247\uff08\u8fbe\u4f2f\u7279\u00ae\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247(\u6377\u5e15\u529b\u00ae)\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u80f6\u56ca\uff08\u8fbe\u4f2f\u4e50\u00ae\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5965\u58f9\u65b0\u00ae\uff09\u548c\u66ff\u59a5\u5c24\u5355\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u65f6\u8fd8\u67093\u4e2a\u54c1\u79cd\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u8bc4\u4e2d\uff0c3\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670916\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002 \u4fe1\u8fbe\u751f\u7269\u5df2\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u621030\u591a\u9879\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u4e0d\u65ad\u81ea\u7814\u521b\u65b0\u836f\u7269\u3001\u8c0b\u6c42\u81ea\u8eab\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u79c9\u627f\u7ecf\u6d4e\u5efa\u8bbe\u4ee5\u4eba\u6c11\u4e3a\u4e2d\u5fc3\u7684\u53d1\u5c55\u601d\u60f3\u3002\u591a\u5e74\u6765\uff0c\u59cb\u7ec8\u5fc3\u6000\u79d1\u5b66\u5584\u5ff5\uff0c\u575a\u5b88\u4ee5&#8221;\u60a3\u8005\u4e3a\u4e2d\u5fc3&#8221;\uff0c\u5fc3\u7cfb\u60a3\u8005\u5e76\u5173\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u79ef\u6781\u5c65\u884c\u793e\u4f1a\u8d23\u4efb\u3002\u4fe1\u8fbe\u751f\u7269\u9646\u7eed\u53d1\u8d77\u3001\u53c2\u4e0e\u4e86\u591a\u9879\u836f\u54c1\u516c\u76ca\u63f4\u52a9\u9879\u76ee\uff0c\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u591f\u5f97\u76ca\u4e8e\u751f\u547d\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u4e70\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8d28\u91cf\u7684\u751f\u7269\u836f\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u8fbe\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9879\u76ee\u5df2\u60e0\u53ca20\u4f59\u4e07\u666e\u901a\u60a3\u8005\uff0c\u836f\u7269\u6350\u8d60\u603b\u4ef7\u503c36\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u4fe1\u8fbe\u751f\u7269\u7f51\u7ad9\uff1a www.innoventbio.com [&hellip;]","og_url":"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c-fruquintinib-\u8054\u5408\u4fe1\u8fea\u5229\/","og_site_name":"Money Compass CN","article_published_time":"2025-03-19T02:17:00+00:00","og_image":[{"width":144,"height":41,"url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/","url":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/","name":"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9 - Money Compass CN","isPartOf":{"@id":"https:\/\/moneycompass.com.my\/cn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#primaryimage"},"image":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#primaryimage"},"thumbnailUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg","datePublished":"2025-03-19T02:17:00+00:00","dateModified":"2025-03-19T02:17:00+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#primaryimage","url":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg","contentUrl":"https:\/\/moneycompass.com.my\/cn\/wp-content\/uploads\/2025\/03\/HUTCHMED_Logo_Logo-7EOUGC.jpeg","width":144,"height":41},{"@type":"BreadcrumbList","@id":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%91%8b%e5%96%b9%e6%9b%bf%e5%b0%bc-fruquintinib-%e8%81%94%e5%90%88%e4%bf%a1%e8%bf%aa%e5%88%a9\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/moneycompass.com.my\/cn\/"},{"@type":"ListItem","position":2,"name":"\u548c\u9ec4\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u544b\u55b9\u66ff\u5c3c (fruquintinib) \u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297 (sintilimab) \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684FRUSICA-2\u4e2d\u56fdII\/III\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9"}]},{"@type":"WebSite","@id":"https:\/\/moneycompass.com.my\/cn\/#website","url":"https:\/\/moneycompass.com.my\/cn\/","name":"Money Compass CN","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/moneycompass.com.my\/cn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/8639"}],"collection":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/comments?post=8639"}],"version-history":[{"count":0,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/posts\/8639\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media\/8640"}],"wp:attachment":[{"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/media?parent=8639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/categories?post=8639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moneycompass.com.my\/cn\/wp-json\/wp\/v2\/tags?post=8639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}