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“2024\u5e74\u5e74\u5e95\uff0c\u6211\u4eec\u51b3\u5b9a\u4ee56.08\u4ebf\u7f8e\u5143\u51fa\u552e\u5728\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a45%\u7684\u80a1\u6743\uff08\u53d6\u51b3\u4e8e\u6210\u4ea4\u6761\u4ef6\uff09\u3002\u6211\u60f3\u501f\u6b64\u673a\u4f1a\u5411\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u7684\u7ba1\u7406\u56e2\u961f\u8868\u793a\u611f\u8c22\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u5e26\u9886\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u5728\u8fc7\u53bb20\u5e74\u95f4\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u589e\u957f\uff0c\u4e3a\u6d88\u8d39\u8005\u548c\u80a1\u4e1c\u5e26\u6765\u4e86\u6301\u7eed\u7684\u83b7\u76ca\u3002\u5176\u6210\u529f\u7684\u5546\u4e1a\u5316\u7ecf\u9a8c\u4ee5\u53ca\u6240\u8d21\u732e\u7684\u8d44\u91d1\u4e3a\u548c\u9ec4\u533b\u836f\u4ece\u4e8b\u65b0\u836f\u7814\u53d1[19]\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u652f\u6301\uff0c\u5e2e\u52a9\u6211\u4eec\u5728\u5f00\u53d1\u521b\u65b0\u836f\u7269\u4ee5\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\u7684\u8fc7\u7a0b\u4e2d\u5e94\u5bf9\u884c\u4e1a\u6311\u6218\u3002\u968f\u7740\u6211\u4eec\u7684\u521b\u65b0\u836f\u4e1a\u52a1\u9010\u6e10\u8d70\u5411\u81ea\u7ed9\u81ea\u8db3\uff0c\u7279\u522b\u662f\u968f\u7740\u6211\u4eec\u5c06\u66f4\u591a\u7684\u6ce8\u610f\u529b\u8f6c\u5411ATTC\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\uff0c\u6211\u4eec\u76f8\u4fe1\u73b0\u5728\u662f\u65f6\u5019\u5e26\u9886\u548c\u9ec4\u533b\u836f\u8fc8\u5165\u4e0b\u4e00\u4e2a\u53d1\u5c55\u9636\u6bb5\u3002\u51fa\u552e\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u6240\u5f97\u6b3e\u9879\uff0c\u518d\u52a0\u4e0a\u4ea7\u54c1\u5168\u7403\u5546\u4e1a\u5316\u5e26\u6765\u7684\u6301\u7eed\u5229\u6da6\uff0c\u4f7f\u6211\u4eec\u5f97\u4ee5\u52a0\u901f\u63a8\u8fdb\u8fd9\u4e00\u5dee\u5f02\u5316\u7684\u65b0\u6280\u672f\u5e73\u53f0\u7684\u53d1\u5c55\uff0c\u5e76\u5c06\u6210\u4e3a\u6211\u4eec\u521b\u9020\u957f\u671f\u4ef7\u503c\u7684\u5173\u952e\u3002”<\/p>\n

\u548c\u9ec4\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u82cf\u6170\u56fd\u535a\u58eb\u8868\u793a\uff1a”\u4eca\u5e74\u662f\u6210\u679c\u4e30\u7855\u7684\u4e00\u5e74\uff0c\u6211\u4eec\u5177\u6709\u9769\u547d\u6027\u7684\u521b\u65b0\u7597\u6cd5\u65e0\u8bba\u662f\u5728\u4e34\u5e8a\u6216\u662f\u5728\u5546\u4e1a\u5316\u65b9\u9762\u5747\u5b9e\u73b0\u4e86\u6211\u4eec\u7684\u6218\u7565\u76ee\u6807\u3002\u8fd9\u7ec8\u4e8e\u4ee4\u548c\u9ec4\u533b\u836f\u5b9e\u73b0\u76c8\u5229\u8fd9\u4e00\u91cd\u8981\u76ee\u6807\u3002\u6211\u8877\u5fc3\u611f\u8c22\u5e76\u795d\u8d3a\u56e2\u961f\u8fbe\u6210\u8fd9\u4e00\u91cc\u7a0b\u7891\uff0c\u63a5\u4e0b\u6765\u6211\u4eec\u5c06\u628a\u6ce8\u610f\u529b\u6295\u5165\u5230\u8fdb\u4e00\u6b65\u7684\u589e\u957f\uff0c\u5e76\u901a\u8fc7\u6211\u4eec\u7684ATTC\u5e73\u53f0\u5b55\u80b2\u548c\u9ec4\u533b\u836f\u7684\u4e0b\u4e00\u6ce2\u521b\u65b0\u836f\u7269\u3002”<\/p>\n

“\u5f00\u521b\u6027\u7684ATTC\u5e73\u53f0\u4e3a\u548c\u9ec4\u533b\u836f\u7684\u521b\u65b0\u836f\u7814\u53d1\u65c5\u7a0b\u63ed\u5f00\u65b0\u7684\u7bc7\u7ae0\uff0c\u5728\u6297\u4f53\u5076\u8054\u836f\u7269\u9886\u57df\u5f00\u8f9f\u65b0\u7684\u65b9\u5411\u3002\u8fd9\u4e9b\u521b\u65b0\u5206\u5b50\u5177\u6709\u6f5c\u529b\u5e7f\u6cdb\u8986\u76d6\u591a\u79cd\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\uff0c\u8574\u542b\u5e9e\u5927\u7684\u5e02\u573a\u6f5c\u80fd\u3002\u51ed\u501f\u5728\u5168\u7403\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u9762\u7684\u4e13\u4e1a\u5b9e\u529b\u4ee5\u53ca\u8d44\u91d1\u4f18\u52bf\uff0c\u6211\u4eec\u8ba1\u5212\u5728\u4eca\u5e74\u8fc5\u901f\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002”<\/p>\n

“\u6211\u4eec\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u836f\u7269\u53d6\u5f97\u4e86\u65b0\u7684\u91cc\u7a0b\u7891\uff0c\u5e76\u7ee7\u7eed\u6269\u5927\u4e34\u5e8a\u5f00\u53d1\u7248\u56fe\uff0c\u60e0\u53ca\u5168\u7403\u66f4\u591a\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u544b\u55b9\u66ff\u5c3c\u73b0\u5df2\u5728\u5341\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u672a\u6765\u5c06\u6269\u5c55\u81f3\u66f4\u591a\u5730\u533a\u3002FRUZAQLA\u00ae\u4e0a\u5e02\u4ec5\u4e00\u5e74\u5185\u9500\u552e\u989d\u5c31\u5df2\u7a81\u78342\u4ebf\u7f8e\u5143\uff0c\u89e6\u53d1\u9996\u4e2a\u9500\u552e\u91cc\u7a0b\u7891\u3002\u5728\u4e2d\u56fd\uff0c\u8be5\u836f\u7269\u8fd8\u83b7\u6279\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\uff0c\u5e73\u5747\u7528\u836f\u65f6\u95f4\u662f\u5176\u9996\u4e2a\u9002\u5e94\u75c7\u7684\u5c06\u8fd1\u4e24\u500d\uff0c\u800c\u7b2c\u4e09\u9879\u7528\u4e8e\u6cbb\u7597\u80be\u764c\u7684FRUSICA-2\u6ce8\u518c\u7814\u7a76\u4ea6\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002”<\/p>\n

“\u81f3\u4e8e\u8d5b\u6c83\u66ff\u5c3c\uff0c\u57fa\u4e8eSACHI\u7814\u7a76\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebfEGFR[20] TKI[21]\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u4f34\u6709MET\u6269\u589e\u60a3\u8005\u7684\u4e2d\u671f\u5206\u6790\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u6211\u4eec\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff0c\u8be5\u7533\u8bf7\u5df2\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u6211\u4eec\u671f\u5f85SAVANNAH\/SAFFRON\u7814\u7a76\u5c06\u652f\u6301\u628a\u8fd9\u79cd\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u7403\u7684\u60a3\u8005\u3002\u8fd1\u671f\uff0c\u968f\u7740\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8\u80ba\u764c\u5747\u53d6\u5f97\u5e38\u89c4\u6279\u51c6\uff0c\u8d5b\u6c83\u66ff\u5c3c\u4ecd\u7136\u662f\u540c\u7c7b\u6700\u4f73\u836f\u7269\u4e4b\u4e00\u3002\u4e00\u9879\u5728MET\u6269\u589e\u80c3\u764c\u4e2d\u5f00\u5c55\u7684\u6ce8\u518c\u610f\u5411\u7814\u7a76\u73b0\u6b63\u5728\u4e2d\u56fd\u5165\u7ec4\u4e2d\u3002\u6211\u4eec\u671f\u5f85\u6709\u671b\u8fdb\u4e00\u6b65\u6269\u5c55\u5176\u9002\u5e94\u75c7\uff0c\u4ee5\u6210\u4e3a\u9996\u4e2a\u7528\u4e8e\u4f34\u6709MET\u6269\u589e\u3001EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53ca\u80c3\u764c\u7684\u836f\u7269\u3002\u6211\u4eec\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u5c06\u7ee7\u7eed\u652f\u6301\u548c\u9ec4\u533b\u836f\u7684\u6536\u5165\u548c\u76c8\u5229\u589e\u957f\u3002”<\/p>\n

“\u7d22\u4e50\u5339\u5c3c\u5e03ESLIM-01\u7814\u7a76\u7684\u6570\u636e\u4e8eEHA\u53caASH\u5e74\u4f1a\u516c\u5e03\uff0c\u6301\u7eed\u5e94\u7b54\u7387\u8fbe51.4%\uff0c\u6574\u4f53\u5e94\u7b54\u7387\u8fbe81.0%\uff0c\u663e\u8457\u4f18\u4e8e\u591a\u79cd\u6b63\u5728\u7814\u53d1\u7684\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u836f\u7269\u3002\u7d22\u4e50\u5339\u5c3c\u5e03\u7684\u8fd9\u4e9b\u4e34\u5e8a\u7ed3\u679c\u518d\u6b21\u5f70\u663e\u548c\u9ec4\u533b\u836f\u5728\u9009\u62e9\u6027\u65b9\u9762\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u4ece\u800c\u5e26\u6765\u7406\u60f3\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u6211\u4eec\u6b63\u4e0e\u56fd\u5bb6\u836f\u76d1\u5c40\u7d27\u5bc6\u6c9f\u901a\uff0c\u671f\u5f85\u5c06\u8fd9\u79cd\u521b\u65b0\u836f\u7269\u5e26\u7ed9\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840[22]\u60a3\u8005\u7684ESLIM-02 III\u671f\u6ce8\u518c\u7814\u7a76\u6b63\u5728\u5165\u7ec4\u4e2d\uff0c\u9884\u8ba1\u660e\u5e74\u516c\u5e03\u7ed3\u679c\u3002\u4e00\u9879\u4ed6\u6cfd\u53f8\u4ed6\uff08tazemetostat\uff09\u7528\u4e8e\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u6b63\u5728\u5ba1\u8bc4\u4e2d\uff0c\u9884\u8ba12025\u5e74\u5e74\u4e2d\u83b7\u6279\u3002\u6211\u4eec\u671f\u5f85\u80fd\u591f\u5c06\u7d22\u4e50\u5339\u5c3c\u5e03\u548c\u4ed6\u6cfd\u53f8\u4ed6\u7eb3\u5165\u5546\u4e1a\u5316\u4ea7\u54c1\u7ec4\u5408\uff0c\u4e3a\u548c\u9ec4\u533b\u836f\u7684\u6301\u7eed\u589e\u957f\u505a\u51fa\u8d21\u732e\u3002”<\/p>\n

2024\u5e74\u5168\u5e74\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55<\/p>\n

I.\u5546\u4e1a\u8425\u8fd0<\/p>\n

2024\u5e74\uff0c\u80bf\u7624\u4ea7\u54c1\u5e02\u573a\u9500\u552e\u989d\u589e\u957f134%\uff08\u6309\u56fa\u5b9a\u6c47\u7387[23]\u8ba1\u7b97\u4e3a136%\uff09\u81f35.01\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a2.136\u4ebf\u7f8e\u5143\uff09\uff0c\u5f97\u76ca\u4e8e\u6b64\uff0c\u80bf\u7624\u4ea7\u54c1\u7efc\u5408\u6536\u5165\u5f3a\u52b2\u589e\u957f65%\uff08\u6309\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u4e3a67%\uff09\u81f32.715\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a1.642\u4ebf\u7f8e\u5143\uff09\u3002<\/p>\n

\u7531\u6b66\u7530\u9500\u552e\u7684FRUZAQLA\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\u7684\u6d77\u5916\u5546\u54c1\u540d\uff092024\u5e74\u7684\u5e02\u573a\u9500\u552e\u989d\u4e3a2.906\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a1,510\u4e07\u7f8e\u5143\uff09\uff0c\u5f3a\u52b2\u7684\u8868\u73b0\u5f97\u76ca\u4e8e\u5728\u7f8e\u56fd\u5e02\u573a\u8fc5\u901f\u83b7\u60a3\u8005\u63a5\u7eb3\uff0c\u4ee5\u53ca\u5728\u5168\u7403\u5341\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u3002\u9500\u552e\u989d\u8fbe\u52302\u4ebf\u7f8e\u5143\uff0c\u89e6\u53d1\u6765\u81ea\u6b66\u75302,000\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff0c\u544b\u55b9\u66ff\u5c3c\u7684\u4e2d\u56fd\u5546\u54c1\u540d\uff092024\u5e74\u7684\u5e02\u573a\u9500\u552e\u989d\u589e\u957f7% \uff08\u6309\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u4e3a9%\uff09\u81f31.15\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a1.075\u4ebf\u7f8e\u5143\uff09\uff0c\u4fdd\u6301\u4e86\u5176\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c[24]\u7684\u9886\u5148\u5e02\u573a\u4efd\u989d\u5730\u4f4d\uff0c\u5bf9\u6765\u81ea\u7ade\u54c1\u53ca\u5176\u4eff\u5236\u836f\u7684\u65e5\u76ca\u589e\u957f\u7684\u538b\u529b\u8868\u73b0\u51fa\u97e7\u6027\u3002\u65b0\u7684\u5b50\u5bab\u5185\u819c\u764c\u9002\u5e94\u75c7\u4e8e2024\u5e7412\u6708\u83b7\u6279\u3002\u82cf\u6cf0\u8fbe\u00ae\uff08SULANDA\u00ae\uff0c\u7d22\u51e1\u66ff\u5c3c\/surufatinib\uff092024\u5e74\u7684\u5e02\u573a\u9500\u552e\u989d\u589e\u957f12% \uff08\u6309\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u4e3a14%\uff09\u81f34,900\u4e07\u7f8e\u5143\u00a0\uff082023\u5e74\uff1a4,390\u4e07\u7f8e\u5143\uff09\uff0c\u5f97\u76ca\u4e8e\u533b\u751f\u5bf9\u8be5\u4ea7\u54c1\u7684\u8ba4\u77e5\u5ea6\u63d0\u5347\u53ca\u795e\u7ecf\u5185\u5206\u6ccc\u7624[25]\u8bca\u65ad\u6539\u5584\uff0c\u63a8\u52a8\u5904\u65b9\u589e\u957f\uff0c2024\u5e74\u5e02\u573a\u4efd\u989d\u63d0\u9ad8\u81f327%\uff082023\u5e74\uff1a21%\uff09\u3002\u6c83\u745e\u6c99\u00ae\uff08ORPATHYS\u00ae\uff0c\u8d5b\u6c83\u66ff\u5c3c\uff092024\u5e74\u7684\u5e02\u573a\u9500\u552e\u989d\u4e0e\u53bb\u5e74\u76f8\u82e5\uff08-2%\uff0c\u6309\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u6301\u5e73\uff09\uff0c\u4e3a4,550\u4e07\u7f8e\u5143\uff082023\u5e74\uff1a4,610\u4e07\u7f8e\u5143\uff09\uff0c\u53d7\u5230\u51e0\u79cd\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8[26]\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u540c\u7c7bMET TKI\u4e0a\u5e02\u4ee5\u53ca\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55[27]\u7684\u7ade\u4e89\u5f71\u54cd\u30022025\u5e741\u6708\u53d6\u5f97\u7684\u4e00\u7ebf[28]\u6cbb\u7597\u5e38\u89c4\u6279\u51c6\u5c1a\u672a\u4e8e\u6b64\u6b21\u7ed3\u679c\u4e2d\u53cd\u6620\u3002<\/p>\n

2024\u5e74\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u7efc\u5408\u6536\u5165\u603b\u989d\u4e3a3.634\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a5.286\u4ebf\u7f8e\u5143\uff09\uff0c\u57283\u4ebf\u7f8e\u5143\u81f34\u4ebf\u7f8e\u5143\u7684\u6307\u5f15\u8303\u56f4\u5185\u3002<\/p>\n

\u53d7FRUZAQLA\u00ae\u7684\u63a8\u52a8\uff0c\u80bf\u7624\u4ea7\u54c1\u7efc\u5408\u6536\u5165\uff08\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3001\u751f\u4ea7\u6536\u5165\u3001\u63a8\u5e7f\u53ca\u8425\u9500\u670d\u52a1\u6536\u5165\u53ca\u5546\u4e1a\u91cc\u7a0b\u7891\uff09\u589e\u957f65%\uff08\u6309\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u4e3a67%\uff09\u81f32.715\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a1.642\u4ebf\u7f8e\u5143\uff09\uff0c\u9ad8\u4e8e30%\u81f350%\u7684\u589e\u957f\u6307\u5f15\u3002\u6765\u81ea\u6b66\u7530\u7684\u9996\u4ed8\u6b3e\u00a0\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u53ca\u7814\u53d1\u670d\u52a1\u6536\u5165\u4e3a6,700\u4e07\u7f8e\u5143\uff082023\u5e74\uff1a3.459\u4ebf\u7f8e\u5143\uff09\uff0c\u5176\u4e2d\u5305\u62ec\u4ece4.5\u4ebf\u7f8e\u5143\u9996\u4ed8\u6b3e\u548c\u76d1\u7ba1\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4e2d\u786e\u8ba4\u76844,810\u4e07\u7f8e\u5143\u3002\u4e0e\u4e4b\u76f8\u8f83\uff0c2023\u5e74\u786e\u8ba4\u4e863.12\u4ebf\u7f8e\u5143\u3002\u5176\u4ed6\u6536\u5165\u4e3a2,490\u4e07\u7f8e\u5143\uff082023\u5e74\uff1a1,850\u4e07\u7f8e\u5143\uff09\uff0c\u5305\u62ec\u6c83\u745e\u6c99\u00ae\u548c\u6cf0\u745e\u6c99\u00ae\u8054\u5408\u7597\u6cd5\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u4e8e\u4e2d\u56fd\u83b7\u53d7\u7406\u540e\u6765\u81ea\u963f\u65af\u5229\u5eb7\u7684600\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u6b3e\u9879\u3002<\/p>\n

\u7efc\u5408\u6536\u5165\u603b\u989d\u4e3a6.302\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a8.38\u4ebf\u7f8e\u5143\uff09\uff0c\u5305\u62ec\u6765\u81ea\u5176\u4ed6\u4e1a\u52a1\u76842.668\u4ebf\u7f8e\u5143\uff082023\u5e74\uff1a3.094\u4ebf\u7f8e\u5143\uff09\u3002<\/p>\n

\n

\uff08\u767e\u4e07\u7f8e\u5143\uff09<\/span><\/p>\n

\u5e02\u573a\u9500\u552e\u989d*<\/span><\/p>\n

\u7efc\u5408\u6536\u5165**<\/span><\/p>\n

<\/p>\n

2024\u5e74<\/span><\/p>\n

2023\u5e74<\/span><\/p>\n

%\u0394<\/span><\/p>\n

(\u56fa\u5b9a\u6c47\u7387)<\/span><\/p>\n

2024\u5e74<\/span><\/p>\n

2023\u5e74\u00a0<\/span><\/p>\n

%\u0394<\/span><\/p>\n

(\u56fa\u5b9a\u6c47\u7387)<\/span><\/p>\n

FRUZAQLA\u00ae<\/span><\/p>\n

$290.6<\/span><\/p>\n

$15.1<\/span><\/p>\n

+1,825\u00a0%<\/span><\/p>\n

(+1,825\u00a0%)<\/span><\/p>\n

$110.8<\/span><\/p>\n

$7.2<\/span><\/p>\n

+1,450\u00a0%<\/span><\/p>\n

(+1,450\u00a0%)<\/span><\/p>\n

\u7231\u4f18\u7279\u00ae<\/span><\/p>\n

$115.0<\/span><\/p>\n

$107.5<\/span><\/p>\n

+7\u00a0%<\/span><\/p>\n

(+9\u00a0%)<\/span><\/p>\n

$86.3<\/span><\/p>\n

$83.2<\/span><\/p>\n

+4\u00a0%<\/span><\/p>\n

(+6\u00a0%)<\/span><\/p>\n

\u82cf\u6cf0\u8fbe\u00ae<\/span><\/p>\n

$49.0<\/span><\/p>\n

$43.9<\/span><\/p>\n

+12\u00a0%<\/span><\/p>\n

(+14\u00a0%)<\/span><\/p>\n

$49.0<\/span><\/p>\n

$43.9<\/span><\/p>\n

+12\u00a0%<\/span><\/p>\n

(+14\u00a0%)<\/span><\/p>\n

\u6c83\u745e\u6c99\u00ae<\/span><\/p>\n

$45.5<\/span><\/p>\n

$46.1<\/span><\/p>\n

-2\u00a0%<\/span><\/p>\n

(+0\u00a0%)<\/span><\/p>\n

$24.5<\/span><\/p>\n

$28.9<\/span><\/p>\n

-15\u00a0%<\/span><\/p>\n

(-13\u00a0%)<\/span><\/p>\n

\u8fbe\u552f\u73c2\u00ae (TAZVERIK\u00ae)<\/span><\/p>\n

$0.9<\/span><\/p>\n

$1.0<\/span><\/p>\n

-8\u00a0%<\/span><\/p>\n

(-7\u00a0%)<\/span><\/p>\n

$0.9<\/span><\/p>\n

$1.0<\/span><\/p>\n

-8\u00a0%<\/span><\/p>\n

(-7\u00a0%)<\/span><\/p>\n

\u80bf\u7624\u4ea7\u54c1<\/span><\/p>\n

$501.0<\/span><\/p>\n

$213.6<\/span><\/p>\n

+134\u00a0%<\/span><\/p>\n

(+136\u00a0%)<\/span><\/p>\n

$271.5<\/span><\/p>\n

$164.2<\/span><\/p>\n

+65\u00a0%<\/span><\/p>\n

(+67\u00a0%)<\/span><\/p>\n

\u6b66\u7530\u9996\u4ed8\u6b3e\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u53ca\u7814\u53d1\u670d\u52a1\u6536\u5165<\/span><\/p>\n

$67.0<\/span><\/p>\n

$345.9<\/span><\/p>\n

-81\u00a0%<\/span><\/p>\n

(-81\u00a0%)<\/span><\/p>\n

\u5176\u4ed6\u6536\u5165 (\u7814\u53d1\u670d\u52a1\u53ca\u8bb8\u53ef)<\/span><\/p>\n

$24.9<\/span><\/p>\n

$18.5<\/span><\/p>\n

+34\u00a0%<\/span><\/p>\n

(+36\u00a0%)<\/span><\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u5408\u8ba1<\/span><\/p>\n

$363.4<\/span><\/p>\n

$528.6<\/span><\/p>\n

-31\u00a0%<\/span><\/p>\n

(-31\u00a0%)<\/span><\/p>\n

\u5176\u4ed6\u4e1a\u52a1<\/span><\/p>\n

$266.8<\/span><\/p>\n

$309.4<\/span><\/p>\n

-14\u00a0%<\/span><\/p>\n

(-12\u00a0%)<\/span><\/p>\n

\u6536\u5165\u603b\u989d<\/span><\/p>\n

$630.2<\/span><\/p>\n

$838.0<\/span><\/p>\n

-25\u00a0%<\/span><\/p>\n

(-24\u00a0%)<\/span><\/p>\n<\/div>\n

\n

*\u00a0=\u00a0\u00a0\u5c31FRUZAQLA \u00ae\u3001\u7231\u4f18\u7279\u00ae\u548c\u6c83\u745e\u6c99\u00ae\uff0c\u4e3b\u8981\u5206\u522b\u4ee3\u8868\u6b66\u7530\u3001\u793c\u6765[29]<\/span><\/span>\u548c\u963f\u65af\u5229\u5eb7\u63d0\u4f9b\u7684\u5bf9\u7b2c\u4e09\u65b9\u7684\u603b\u9500\u552e\u989d\u3002<\/span><\/p>\n

**\u00a0=\u00a0\u5c31FRUZAQLA \u00ae\uff0c\u4ee3\u8868\u6b66\u7530\u652f\u4ed8\u7684\u751f\u4ea7\u6536\u5165\u3001\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u53ca\u5546\u4e1a\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff1b\u5c31\u7231\u4f18\u7279\u00ae\uff0c\u4ee3\u8868\u793c\u6765\u5411\u548c\u9ec4\u533b\u836f
\u652f\u4ed8\u7684\u751f\u4ea7\u6536\u5165\u3001\u63a8\u5e7f\u53ca\u8425\u9500\u670d\u52a1\u6536\u5165\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u4ee5\u53ca\u7531\u548c\u9ec4\u533b\u836f\u5f00\u5177\u53d1\u7968\u7684\u5bf9\u5176\u4ed6\u7b2c\u4e09\u65b9\u7684\u9500\u552e\u989d\uff1b\u5c31\u6c83\u745e\u6c99\u00ae\uff0c
\u4ee3\u8868\u963f\u65af\u5229\u5eb7\u5411\u548c\u9ec4\u533b\u836f\u652f\u4ed8\u7684\u751f\u4ea7\u6536\u5165\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u4ee5\u53ca\u7531\u548c\u9ec4\u533b\u836f\u5f00\u5177\u53d1\u7968\u7684\u5bf9\u5176\u4ed6\u7b2c\u4e09\u65b9\u7684\u9500\u552e\u989d\uff1b\u5c31\u82cf\u6cf0\u8fbe
\u00ae\u53ca\u8fbe\u552f\u73c2\u00ae\uff0c\u4ee3\u8868\u548c\u9ec4\u533b\u836f\u5bf9\u7b2c\u4e09\u65b9\u7684\u4ea7\u54c1\u9500\u552e\u989d\u3002<\/span><\/p>\n

<\/p><\/div>\n

II.\u6ce8\u518c\u5ba1\u6279\u8fdb\u5c55<\/p>\n

\u4e2d\u56fd<\/p>\n

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\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u6210\u4eba\u60a3\u8005\u7684ESLIM-01\u4e2d\u56fdIII\u671f\u7814\u7a76\u7ed3\u679c\u4e8e\u00a0\u300a\u67f3\u53f6\u5200\u2022\u8840\u6db2\u75c5\u5b66\uff08The Lancet Haematology\uff09\u300b\u53caEHA\u5e74\u4f1a\u4e0a\u540c\u6b65\u53d1\u8868\uff0c\u7ed3\u679c\u663e\u793a\u6301\u7eed\u5e94\u7b54\u7387\u4e3a48.4%\uff0c\u4e14\u65e0\u8bba\u60a3\u8005\u65e2\u5f80\u7684\u6cbb\u7597\u7ebf\u6570\u5747\u5c55\u73b0\u51fa\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\u7279\u5f81\u53ca\u751f\u6d3b\u8d28\u91cf\u6539\u5584\uff08NCT05029635\uff09\u3002ESLIM-01\u4e2d\u56fdIII\u671f\u7814\u7a76\u7684\u957f\u671f\u7814\u7a76\u7ed3\u679c\u4e8eASH\u5e74\u4f1a\u4e0a\u53d1\u8868\uff0c\u7ed3\u679c\u663e\u793a\u6301\u7eed\u5e94\u7b54\u7387\u4e3a51.4%\u53ca\u957f\u671f\u6301\u7eed\u5e94\u7b54\u7387\u4e3a59.8%\uff0c\u5e76\u5c55\u73b0\u51fa\u4e00\u81f4\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u75c7\u7684\u4e2d\u56fdII\u671f\u7814\u7a76\u7ed3\u679c\u4e8eEHA\u5e74\u4f1a\u4e0a\u516c\u5e03\u53ca\u4e8e2025\u5e74\u5728\u300a\u67f3\u53f6\u5200\u2022\u8840\u6db2\u75c5\u5b66\uff08The Lancet Haematology\uff09\u300b\u4e0a\u53d1\u8868\u00a0\uff0c\u7ed3\u679c\u663e\u793a\u6574\u4f53\u5e94\u7b54\u7387\u4e3a66.7%\uff0c\u5e76\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff08NCT05535933\uff09\u3002\u4e8e\u4e2d\u56fd\u542f\u52a8\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u75c7\u7684ESLIM-02\u7814\u7a76\u7684III\u671f\u9636\u6bb5\uff08NCT05535933\uff09\u3002<\/p>\n

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\u4e8e2025\u5e74\u5e74\u5e95\u5de6\u53f3\u5b8c\u6210\u57fa\u4e8e ESLIM-01\u7814\u7a76\u7684\u56fd\u5bb6\u836f\u76d1\u5c40\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5ba1\u8bc4\uff08NCT05029635\uff09\u3002\u4e8e2025\u5e74\u4e0b\u534a\u5e74\u5b8c\u6210ESLIM-02 III\u671f\u7814\u7a76\u7684\u60a3\u8005\u62db\u52df\uff08NCT05535933\uff09\u3002<\/p>\n

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HMPL-453 \uff08fanregratinib\uff09\uff0c\u4e00\u79cd\u65b0\u578b\u3001\u9ad8\u9009\u62e9\u6027\u53ca\u5f3a\u6548\u7684FGFR 1\/2\/3\u6291\u5236\u5242<\/p>\n

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2024\u5e74\u7684\u51c0\u5f00\u652f\u4e3a5.925\u4ebf\u7f8e\u5143\uff0c\u800c2023\u5e74\u4e3a7.372\u4ebf\u7f8e\u5143\uff0c\u53cd\u6620\u5728\u6210\u672c\u63a7\u5236\u65b9\u9762\u4f5c\u51fa\u7684\u5de8\u5927\u52aa\u529b\u3002<\/p>\n

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2024\u5e74\u548c\u9ec4\u533b\u836f\u5e94\u5360\u51c0\u6536\u76ca\u4e3a3,770\u4e07\u7f8e\u5143\uff0c\u800c2023\u5e74\u5219\u4e3a1.008\u4ebf\u7f8e\u5143\u3002<\/p>\n

2024\u5e74\u548c\u9ec4\u533b\u836f\u5e94\u5360\u51c0\u6536\u76ca\u4e3a\u6bcf\u80a1\u666e\u901a\u80a10.04\u7f8e\u5143\/\u6bcf\u4efdADS[59]0.22\u7f8e\u5143\uff0c\uff082023\u5e74\uff1a\u6bcf\u80a1\u666e\u901a\u80a10.12\u7f8e\u5143\/\u6bcf\u4efdADS0.59\u7f8e\u5143\uff09\u3002<\/p>\n

\u4e8e2024\u5e7412\u670831\u65e5\uff0c\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u548c\u77ed\u671f\u6295\u8d44\u5408\u8ba1\u4e3a8.361\u4ebf\u7f8e\u5143\uff0c\u800c\u4e8e2023\u5e7412\u670831\u65e5\u4e3a8.863\u4ebf\u7f8e\u5143\u3002<\/p>\n

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\u8d22\u52a1\u6307\u5f15<\/p>\n

\u548c\u9ec4\u533b\u836f\u63d0\u4f9b\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u7efc\u5408\u6536\u5165\u76842025\u5e74\u5168\u5e74\u6307\u5f15\u4e3a3.5\u4ebf\u7f8e\u5143\u81f34.5\u4ebf\u7f8e\u5143\u3002\u548c\u9ec4\u533b\u836f\u5f3a\u52b2\u7684\u8d22\u52a1\u72b6\u51b5\u5c06\u4e3a\u51762025\u5e74\u53ca\u5176\u540e\u4e1a\u52a1\u63d0\u4f9b\u652f\u63f4\u3002\u516c\u53f8\u5c06\u7ee7\u7eed\u5728\u8d22\u52a1\u4e0a\u81ea\u7ed9\u81ea\u8db3\uff0c\u540c\u65f6\u652f\u6301\u6295\u8d44\uff0c\u5c06\u521b\u65b0\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\u3002<\/p>\n

\u80a1\u4e1c\u53ca\u6295\u8d44\u8005\u5e94\u6ce8\u610f\uff1a<\/p>\n

\u672c\u516c\u53f8\u4e0d\u4fdd\u8bc1\u8d22\u52a1\u6307\u5f15\u4e2d\u5305\u542b\u7684\u9648\u8ff0\u5c06\u5b9e\u73b0\uff0c\u6216\u5176\u4e2d\u5305\u542b\u7684\u8d22\u52a1\u4e1a\u7ee9\u5c06\u5b9e\u73b0\u6216\u53ef\u80fd\u5b9e\u73b0\uff1b\u53ca\u00a0\u672c\u516c\u53f8\u8fc7\u53bb\u66fe\u4fee\u8ba2\u6211\u4eec\u7684\u8d22\u52a1\u6307\u5f15\uff0c\u56e0\u6b64\u5e94\u53c2\u8003\u6211\u4eec\u5728\u672c\u516c\u544a\u520a\u53d1\u65e5\u671f\u540e\u5c31\u4efb\u4f55\u8d22\u52a1\u6307\u5f15\u66f4\u65b0\u7684\u516c\u544a\u3002\u00a0<\/p>\n

\u2014\u2014\u2014<\/span><\/p>\n

\u975eGAAP\u8d22\u52a1\u6307\u6807\u7684\u4f7f\u7528\u548c\u8c03\u8282 \u2014 \u672c\u516c\u544a\u4e2d\u63d0\u53ca\u4e0d\u5305\u62ec\u878d\u8d44\u6d3b\u52a8\u7684\u8c03\u6574\u540e\u96c6\u56e2\u51c0\u73b0\u91d1\u6d41\u53ca\u6309\u7167\u56fa\u5b9a\u6c47\u7387\u8ba1\u7b97\u62a5\u544a\u7684\u8d22\u52a1\u6307\u6807\u5747\u57fa\u4e8e\u975eGAAP\u8d22\u52a1\u6307\u6807\u3002\u8bf7\u53c2\u9605”\u975eGAAP\u8d22\u52a1\u6307\u6807\u7684\u4f7f\u7528\u548c\u8c03\u8282”\uff0c\u4ee5\u5206\u522b\u4e86\u89e3\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u7684\u89e3\u91ca\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u4e0e\u6700\u5177\u53ef\u6bd4\u6027\u7684GAAP\u6307\u6807\u8c03\u8282\u7684\u8fdb\u4e00\u6b65\u8d44\u6599\u3002<\/p>\n

\u2014\u2014\u2014<\/span><\/p>\n

\u8d22\u52a1\u62a5\u8868<\/p>\n

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\u8d22\u52a1\u6982\u8981<\/span><\/p>\n

\n

\u7b80\u660e\u7efc\u5408\u8d44\u4ea7\u8d1f\u503a\u8868\u6570\u636e<\/span><\/p>\n

\uff08\u5343\u7f8e\u5143\uff09<\/span><\/p>\n

\u4e8e12\u670831\u65e5<\/span><\/p>\n

<\/p>\n

2024\u5e74<\/span><\/p>\n

<\/p>\n

2023\u5e74<\/span><\/p>\n

\u8d44\u4ea7<\/span><\/p>\n

<\/p>\n

\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u548c\u77ed\u671f\u6295\u8d44<\/span><\/p>\n

836,110<\/span><\/p>\n

<\/p>\n

886,336<\/span><\/p>\n

\u5e94\u6536\u8d26\u6b3e<\/span><\/p>\n

155,537<\/span><\/p>\n

<\/p>\n

116,894<\/span><\/p>\n

\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n

74,908<\/span><\/p>\n

<\/p>\n

93,609<\/span><\/p>\n

\u7269\u4e1a\u3001\u5382\u623f\u53ca\u8bbe\u5907<\/span><\/p>\n

92,498<\/span><\/p>\n

<\/p>\n

99,727<\/span><\/p>\n

\u5408\u8d44\u4f01\u4e1a\u6743\u76ca<\/span><\/p>\n

77,765<\/span><\/p>\n

<\/p>\n

48,411<\/span><\/p>\n

\u5176\u4ed6\u975e\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n

37,378<\/span><\/p>\n

<\/p>\n

34,796<\/span><\/p>\n

\u8d44\u4ea7\u603b\u989d<\/span><\/p>\n

1,274,196<\/span><\/p>\n

<\/p>\n

1,279,773<\/span><\/p>\n

\u8d1f\u503a\u53ca\u80a1\u4e1c\u6743\u76ca<\/span><\/p>\n

<\/p>\n

\u5e94\u4ed8\u8d26\u6b3e<\/span><\/p>\n

42,521<\/span><\/p>\n

<\/p>\n

36,327<\/span><\/p>\n

\u5176\u4ed6\u5e94\u4ed8\u6b3e\u3001\u5e94\u8ba1\u5f00\u652f\u53ca\u9884\u6536\u6b3e\u9879<\/span><\/p>\n

256,124<\/span><\/p>\n

<\/p>\n

271,399<\/span><\/p>\n

\u9012\u5ef6\u6536\u5165<\/span><\/p>\n

98,503<\/span><\/p>\n

<\/p>\n

127,119<\/span><\/p>\n

\u94f6\u884c\u8d37\u6b3e<\/span><\/p>\n

82,806<\/span><\/p>\n

<\/p>\n

79,344<\/span><\/p>\n

\u5176\u4ed6\u8d1f\u503a<\/span><\/p>\n

22,389<\/span><\/p>\n

<\/p>\n

22,197<\/span><\/p>\n

\u8d1f\u503a\u603b\u989d<\/span><\/p>\n

502,343<\/span><\/p>\n

<\/p>\n

536,386<\/span><\/p>\n

\u672c\u516c\u53f8\u80a1\u4e1c\u6743\u76ca<\/span><\/p>\n

759,929<\/span><\/p>\n

<\/p>\n

730,541<\/span><\/p>\n

\u975e\u63a7\u80a1\u6743\u76ca<\/span><\/p>\n

11,924<\/span><\/p>\n

<\/p>\n

12,846<\/span><\/p>\n

\u8d1f\u503a\u53ca\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/span><\/p>\n

1,274,196<\/span><\/p>\n

<\/p>\n

1,279,773<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

\n

\u7b80\u660e\u7efc\u5408\u7ecf\u8425\u8868\u8d44\u6599<\/span><\/p>\n

\uff08\u5343\u7f8e\u5143\uff0c\u80a1\u4efd\u548c\u6bcf\u80a1\u6570\u636e\u9664\u5916\uff09<\/span><\/p>\n

\u622a\u81f312\u670831\u65e5\u6b62\u5e74\u5ea6<\/span><\/p>\n

<\/p>\n

2024\u5e74<\/span><\/p>\n

<\/p>\n

2023\u5e74<\/span><\/p>\n

\u6536\u5165:<\/span><\/p>\n

<\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u2014\u4e0a\u5e02\u4ea7\u54c1<\/span><\/p>\n

271,534<\/span><\/p>\n

<\/p>\n

164,165<\/span><\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u2014\u7814\u53d1<\/span><\/p>\n

91,831<\/span><\/p>\n

<\/p>\n

364,451<\/span><\/p>\n

\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u7efc\u5408\u6536\u5165<\/span><\/p>\n

363,365<\/span><\/p>\n

<\/p>\n

528,616<\/span><\/p>\n

\u5176\u4ed6\u4e1a\u52a1<\/span><\/p>\n

266,836<\/span><\/p>\n

<\/p>\n

309,383<\/span><\/p>\n

\u6536\u5165\u603b\u989d<\/span><\/p>\n

630,201<\/span><\/p>\n

<\/p>\n

837,999<\/span><\/p>\n

\u7ecf\u8425\u5f00\u652f:<\/span><\/p>\n

<\/p>\n

\u6536\u5165\u6210\u672c<\/span><\/p>\n

(348,884)<\/span><\/p>\n

<\/p>\n

(384,447)<\/span><\/p>\n

\u7814\u53d1\u5f00\u652f<\/span><\/p>\n

(212,109)<\/span><\/p>\n

<\/p>\n

(302,001)<\/span><\/p>\n

\u9500\u552e\u53ca\u884c\u653f\u5f00\u652f<\/span><\/p>\n

(112,913)<\/span><\/p>\n

<\/p>\n

(133,176)<\/span><\/p>\n

\u7ecf\u8425\u5f00\u652f\u603b\u989d<\/span><\/p>\n

(673,906)<\/span><\/p>\n

<\/p>\n

(819,624)<\/span><\/p>\n

\u5176\u4ed6\u6536\u76ca\u51c0\u989d<\/span><\/p>\n

42,598<\/span><\/p>\n

<\/p>\n

39,933<\/span><\/p>\n

\u9664\u6240\u5f97\u7a0e\u5f00\u652f\u53ca\u5408\u8d44\u4f01\u4e1a\u6743\u76ca\u6536\u76ca\u524d\uff08\u4e8f\u635f\uff09\/\u6536\u76ca<\/span><\/p>\n

(1,107)<\/span><\/p>\n

<\/p>\n

58,308<\/span><\/p>\n

\u6240\u5f97\u7a0e\u5f00\u652f<\/span><\/p>\n

(7,192)<\/span><\/p>\n

<\/p>\n

(4,509)<\/span><\/p>\n

\u6240\u5360\u5408\u8d44\u4f01\u4e1a\u6743\u76ca\u9664\u7a0e\u540e\u6536\u76ca<\/span><\/p>\n

46,469<\/span><\/p>\n

<\/p>\n

47,295<\/span><\/p>\n

\u51c0\u6536\u76ca<\/span><\/p>\n

38,170<\/span><\/p>\n

<\/p>\n

101,094<\/span><\/p>\n

\u51cf\uff1a\u975e\u63a7\u80a1\u6743\u76ca\u5e94\u5360\u51c0\u6536\u76ca<\/span><\/p>\n

(441)<\/span><\/p>\n

<\/p>\n

(314)<\/span><\/p>\n

\u548c\u9ec4\u533b\u836f\u5e94\u5360\u51c0\u6536\u76ca<\/span><\/p>\n

37,729<\/span><\/p>\n

<\/p>\n

100,780<\/span><\/p>\n

\u548c\u9ec4\u533b\u836f\u5e94\u5360\u6bcf\u80a1\u666e\u901a\u80a1\u76c8\u5229\uff08\u6bcf\u80a1\u666e\u901a\u80a1\uff0c\u7f8e\u5143\uff09\u00a0<\/span><\/p>\n

<\/p>\n

\u2013 \u57fa\u672c<\/span><\/p>\n

0.04<\/span><\/p>\n

<\/p>\n

0.12<\/span><\/p>\n

\u2013 \u644a\u8584<\/span><\/p>\n

0.04<\/span><\/p>\n

<\/p>\n

0.12<\/span><\/p>\n

\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u76c8\u5229\u6240\u7528\u80a1\u6570<\/span><\/p>\n

<\/p>\n

\u2013 \u57fa\u672c<\/span><\/p>\n

855,351,683<\/span><\/p>\n

<\/p>\n

849,654,296<\/span><\/p>\n

\u2013 \u644a\u8584<\/span><\/p>\n

872,829,129<\/span><\/p>\n

<\/p>\n

869,196,348<\/span><\/p>\n

\u548c\u9ec4\u533b\u836f\u5e94\u5360\u6bcf\u4efdADS\u76c8\u5229\uff08\u6bcf\u4efdADS\uff0c\u7f8e\u5143\uff09<\/span><\/p>\n

<\/p>\n

\u2013 \u57fa\u672c<\/span><\/p>\n

0.22<\/span><\/p>\n

<\/p>\n

0.59<\/span><\/p>\n

\u2013 \u644a\u8584<\/span><\/p>\n

0.22<\/span><\/p>\n

<\/p>\n

0.58<\/span><\/p>\n

\u8ba1\u7b97\u6bcf\u4efdADS\u76c8\u5229\u6240\u7528\u7684ADS\u4efd\u6570<\/span><\/p>\n

<\/p>\n

\u2013 \u57fa\u672c<\/span><\/p>\n

171,070,337<\/span><\/p>\n

<\/p>\n

169,930,859<\/span><\/p>\n

\u2013 \u644a\u8584<\/span><\/p>\n

174,565,826<\/span><\/p>\n

<\/p>\n

173,839,270<\/span><\/p>\n<\/div>\n

\u5173\u4e8e\u548c\u9ec4\u533b\u836f<\/p>\n

\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u81f4\u529b\u4e8e\u5c06\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u5e26\u5411\u5168\u7403\u60a3\u8005\uff0c\u9996\u4e09\u4e2a\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5176\u4e2d\u9996\u4e2a\u836f\u7269\u4ea6\u4e8e\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7b49\u5168\u7403\u5404\u5730\u83b7\u6279\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1awww.hutch-med.com<\/a>\u00a0\u6216\u5173\u6ce8\u6211\u4eec\u7684\u9886\u82f1<\/a>\u4e13\u9875\u3002<\/p>\n

\u7b80\u79f0\u4f7f\u7528<\/p>\n

\u9664\u6587\u610f\u53e6\u6709\u6240\u6307\u5916\uff0c\u5426\u5219\u672c\u516c\u544a\u4e2d\u6240\u79f0”\u96c6\u56e2”\u3001”\u516c\u53f8”\u3001”\u548c\u9ec4\u533b\u836f”\u3001”\u548c\u9ec4\u533b\u836f\u96c6\u56e2”\u3001”\u6211\u4eec”\u548c”\u6211\u4eec\u7684”\u6307\u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\u53ca\u5176\u9644\u5c5e\u516c\u53f8\uff0c\u9664\u975e\u6587\u4e2d\u53e6\u6709\u8bf4\u660e\u6216\u6307\u660e\u3002<\/p>\n

\u8fc7\u5f80\u4e1a\u7ee9\u548c\u524d\u77bb\u6027\u9648\u8ff0<\/p>\n

\u672c\u516c\u544a\u6240\u8f7d\u672c\u96c6\u56e2\u4e4b\u8868\u73b0\u548c\u7ecf\u8425\u4e1a\u7ee9\u5c5e\u5386\u53f2\u6027\u8d28\uff0c\u4e14\u8fc7\u5f80\u8868\u73b0\u5e76\u4e0d\u4fdd\u8bc1\u672c\u96c6\u56e2\u4e4b\u672a\u6765\u4e1a\u7ee9\u3002\u672c\u516c\u544a\u5305\u542b\u7b26\u54081995\u5e74\u300a\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b”\u5b89\u5168\u6e2f”\u6761\u6b3e\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3002\u8be5\u7b49\u524d\u77bb\u6027\u9648\u8ff0\u53ef\u4ee5\u7528\u8bf8\u5982”\u5c06\u4f1a”\u3001”\u671f\u671b”\u3001”\u9884\u671f”\u3001”\u672a\u6765”\u3001”\u6253\u7b97”\u3001”\u8ba1\u5212”\u3001”\u76f8\u4fe1”\u3001\u00a0“\u4f30\u8ba1”\u3001”\u7b79\u5907”\u3001”\u53ef\u80fd”\u3001”\u6f5c\u5728”\u3001”\u540c\u7c7b\u9996\u521b”\u3001”\u540c\u7c7b\u6700\u4f73”\u3001”\u65e8\u5728”\u3001”\u76ee\u6807”\u3001”\u6307\u5bfc”\u3001”\u8ffd\u6c42”\u6216\u7c7b\u4f3c\u672f\u8bed\uff0c\u6216\u901a\u8fc7\u5bf9\u6f5c\u5728\u5019\u9009\u836f\u7269\u3001\u6f5c\u5728\u5019\u9009\u836f\u7269\u9002\u5e94\u75c7\u7684\u660e\u793a\u6216\u6697\u793a\u8ba8\u8bba\uff0c\u6216\u901a\u8fc7\u8ba8\u8bba\u6218\u7565\u3001\u8ba1\u5212\u3001\u9884\u671f\u6216\u610f\u56fe\u6765\u8bc6\u522b\u3002\u9601\u4e0b\u8bf7\u52ff\u8fc7\u5206\u501a\u8d56\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\u3002\u8be5\u7b49\u524d\u77bb\u6027\u9648\u8ff0\u53cd\u6620\u4e86\u7ba1\u7406\u5c42\u6839\u636e\u76ee\u524d\u7684\u4fe1\u5ff5\u548c\u671f\u671b\u800c\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u9884\u671f\uff0c\u5e76\u53d7\u5230\u5df2\u77e5\u53ca\u672a\u77e5\u98ce\u9669\u4e0e\u4e0d\u786e\u5b9a\u6027\u7684\u5f71\u54cd\u3002\u5982\u82e5\u8be5\u7b49\u98ce\u9669\u6216\u4e0d\u786e\u5b9a\u6027\u4e2d\u7684\u4e00\u9879\u6216\u591a\u9879\u51fa\u73b0\uff0c\u6216\u8005\u57fa\u672c\u5047\u8bbe\u88ab\u8bc1\u660e\u5c5e\u4e0d\u6b63\u786e\uff0c\u5219\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u8f7d\u4e4b\u7ed3\u679c\u6709\u91cd\u5927\u51fa\u5165\u3002\u548c\u9ec4\u533b\u836f\u4e0d\u80fd\u4fdd\u8bc1\u5176\u4efb\u4f55\u5019\u9009\u836f\u7269\u5747\u5c06\u4f1a\u5728\u4efb\u4f55\u5e02\u573a\u4e0a\u83b7\u51c6\u9500\u552e\uff0c\u4ea6\u4e0d\u80fd\u4fdd\u8bc1\u5df2\u83b7\u5f97\u7684\u4efb\u4f55\u6279\u51c6\u5728\u672a\u6765\u7ee7\u7eed\u6709\u6548\uff0c\u6216\u8005\u7531\u548c\u9ec4\u533b\u836f\u53ca\/\u6216\u5176\u5408\u4f5c\u4f19\u4f34\u9500\u552e\u6216\u4ee5\u5176\u4ed6\u65b9\u5f0f\u5c06\u4ea7\u54c1\u5546\u4e1a\u5316\uff08\u7edf\u79f0”\u548c\u9ec4\u533b\u836f\u4ea7\u54c1”\uff09\u5c06\u8fbe\u5230\u4efb\u4f55\u7279\u5b9a\u7684\u6536\u5165\u6216\u51c0\u6536\u76ca\u6c34\u5e73\u3002\u548c\u9ec4\u533b\u836f\u7ba1\u7406\u5c42\u7684\u9884\u671f\u53ef\u80fd\u4f1a\u53d7\u5230\u4ee5\u4e0b\u56e0\u7d20\u7684\u5f71\u54cd\uff1a\u610f\u6599\u4e4b\u5916\u7684\u76d1\u7ba1\u884c\u52a8\u6216\u5ef6\u8fdf\u6216\u4e00\u822c\u6027\u7684\u653f\u5e9c\u76d1\u7ba1\uff1b\u7814\u7a76\u4e0e\u5f00\u53d1\u4e2d\u56fa\u6709\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5305\u62ec\u65e0\u6cd5\u6ee1\u8db3\u5173\u952e\u7684\u5173\u4e8e\u53d7\u8bd5\u8005\u7684\u6ce8\u518c\u7387\u3001\u65f6\u673a\u548c\u53ef\u7528\u6027\u7684\u7814\u7a76\u5047\u8bbe\uff0c\u5176\u8981\u7b26\u5408\u7814\u7a76\u7684\u7eb3\u5165\u53ca\u6392\u9664\u6807\u51c6\u4ee5\u53ca\u8d44\u91d1\u8981\u6c42\uff0c\u4e34\u5e8a\u65b9\u6848\u7684\u53d8\u66f4\u3001\u610f\u5916\u4e0d\u5229\u4e8b\u4ef6\u6216\u5b89\u5168\u6027\u3001\u8d28\u91cf\u6216\u751f\u4ea7\u65b9\u9762\u7684\u95ee\u9898\uff1b\u5019\u9009\u836f\u7269\u5ef6\u8fdf\u6216\u65e0\u6cd5\u6ee1\u8db3\u784f\u7a76\u7684\u4e3b\u8981\u6216\u6b21\u8981\u7ec8\u70b9\uff1b\u5019\u9009\u836f\u7269\u5ef6\u8fdf\u6216\u65e0\u6cd5\u83b7\u5f97\u4e0d\u540c\u53f8\u6cd5\u7ba1\u8f96\u533a\u7684\u76d1\u7ba1\u6279\u51c6\u6216\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u83b7\u5f97\u76d1\u7ba1\u6279\u51c6\u540e\u7684\u4f7f\u7528\u60c5\u51b5\uff0c\u5e02\u573a\u8ba4\u53d7\u6027\u53ca\u5546\u4e1a\u6210\u529f\uff1b\u6240\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\/\u6216\u5546\u4e1a\u5316\u7ade\u4e89\u4ea7\u54c1\u548c\u5019\u9009\u836f\u7269\u53ef\u80fd\u6bd4\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u53ca\u5019\u9009\u836f\u7269\u66f4\u6709\u4f18\u52bf\u6216\u66f4\u5177\u6210\u672c\u6548\u76ca\uff1b\u653f\u5e9c\u5f53\u5c40\u548c\u5176\u4ed6\u7b2c\u4e09\u65b9\u7684\u7814\u7a76\uff08\u65e0\u8bba\u7531\u548c\u9ec4\u533b\u836f\u6216\u5176\u4ed6\u4eba\u58eb\u8fdb\u884c\u53ca\u65e0\u8bba\u5c5e\u5f3a\u5236\u6216\u81ea\u613f\uff09\u6216\u5efa\u8bae\u53ca\u6307\u5f15\u5bf9\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u53ca\u5f00\u53d1\u4e2d\u7684\u5019\u9009\u836f\u7269\u7684\u5546\u4e1a\u6210\u529f\u7684\u5f71\u54cd\uff1b\u548c\u9ec4\u533b\u836f\u5236\u9020\u53ca\u7ba1\u7406\u591a\u79cd\u4ea7\u54c1\u53ca\u5019\u9009\u836f\u7269\u4f9b\u5e94\u94fe\u7684\u80fd\u529b\uff08\u5305\u62ec\u5404\u79cd\u7b2c\u4e09\u65b9\u670d\u52a1\uff09\uff1b\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u80fd\u5426\u4ece\u7b2c\u4e09\u65b9\u652f\u4ed8\u673a\u6784\u83b7\u5f97\u62a5\u9500\u53ca\u83b7\u62a5\u9500\u7684\u7a0b\u5ea6\uff0c\u5305\u62ec\u79c1\u4eba\u652f\u4ed8\u673a\u6784\u7684\u533b\u7597\u5065\u5eb7\u53ca\u4fdd\u9669\u8ba1\u5212\u4ee5\u53ca\u653f\u5e9c\u4fdd\u9669\u8ba1\u5212\uff1b\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u9500\u552e\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u7684\u6210\u672c\uff1b\u5728\u9700\u8981\u65f6\u83b7\u5f97\u989d\u5916\u8d44\u91d1\u7684\u80fd\u529b\uff1b\u4e3a\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u548c\u5019\u9009\u836f\u7269\u83b7\u5f97\u5e76\u7ef4\u6301\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u80fd\u529b\uff1b\u548c\u9ec4\u533b\u836f\u5b9e\u73b0\u5176\u4efb\u4f55\u8d22\u52a1\u9884\u6d4b\u6216\u6307\u5f15\u7684\u80fd\u529b\u4ee5\u53ca\u8be5\u7b49\u9884\u6d4b\u6216\u6307\u5f15\u6240\u4f9d\u636e\u7684\u5047\u8bbe\u7684\u53d8\u5316\uff1b\u6210\u529f\u51fa\u552e\u975e\u6838\u5fc3\u4e1a\u52a1\uff1b\u904f\u5236\u533b\u7597\u6210\u672c\u7684\u5168\u7403\u8d8b\u52bf\uff0c\u5305\u62ec\u6301\u7eed\u7684\u4ef7\u683c\u538b\u529b\uff1b\u5b9e\u9645\u548c\u6f5c\u5728\u6cd5\u5f8b\u7a0b\u5e8f\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5176\u4e2d\u5305\u62ec\u5b9e\u9645\u6216\u6f5c\u5728\u4ea7\u54c1\u8d23\u4efb\u8bc9\u8bbc\u3001\u6709\u5173\u9500\u552e\u548c\u884c\u9500\u884c\u4e3a\u7684\u8bc9\u8bbc\u548c\u8c03\u67e5\u3001\u77e5\u8bc6\u4ea7\u6743\u7ea0\u7eb7\u4ee5\u53ca\u4e00\u822c\u6027\u7684\u653f\u5e9c\u8c03\u67e5\uff1b\u4ee5\u53ca\u6574\u4f53\u7ecf\u6d4e\u548c\u884c\u4e1a\u72b6\u51b5\uff0c\u5305\u62ec\u8bb8\u591a\u56fd\u5bb6\u6301\u7eed\u75b2\u5f31\u7684\u7ecf\u6d4e\u548c\u91d1\u878d\u73af\u5883\u5f71\u54cd\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u672a\u6765\u5168\u7403\u6c47\u7387\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5168\u7403\u6c47\u7387\u3001\u5730\u7f18\u653f\u6cbb\u5173\u7cfb\u3001\u5236\u88c1\u548c\u5173\u7a0e\u7684\u4e0d\u786e\u5b9a\u6027\u3002\u6709\u5173\u524d\u8ff0\u5404\u9879\u548c\u5176\u4ed6\u98ce\u9669\u7684\u8fdb\u4e00\u6b65\u8ba8\u8bba\uff0c\u8bf7\u53c2\u9605\u548c\u9ec4\u533b\u836f\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u3001\u4f26\u6566\u8bc1\u5238\u4ea4\u6613\u6240\u548c\u9999\u6e2f\u4ea4\u6613\u6240\u63d0\u4ea4\u7684\u6587\u4ef6\u3002\u548c\u9ec4\u533b\u836f\u5728\u672c\u516c\u544a\u4e2d\u63d0\u4f9b\u4e4b\u8d44\u6599\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u5e76\u4e14\u4e0d\u627f\u62c5\u56e0\u65b0\u7684\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u66f4\u65b0\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u7684\u4e49\u52a1\u3002<\/p>\n

\u6b64\u5916\uff0c\u672c\u516c\u544a\u5305\u542b\u548c\u9ec4\u533b\u836f\u4ece\u884c\u4e1a\u51fa\u7248\u7269\u548c\u7b2c\u4e09\u65b9\u5e02\u573a\u7814\u7a76\u516c\u53f8\u4f5c\u51fa\u7684\u62a5\u544a\u4e2d\u83b7\u5f97\u7684\u7edf\u8ba1\u6570\u636e\u548c\u4f30\u8ba1\u3002\u5c3d\u7ba1\u548c\u9ec4\u533b\u836f\u8ba4\u4e3a\u8be5\u7b49\u51fa\u7248\u7269\u3001\u62a5\u544a\u548c\u8c03\u67e5\u7814\u7a76\u662f\u53ef\u9760\u7684\uff0c\u4f46\u662f\u548c\u9ec4\u533b\u836f\u5c1a\u672a\u72ec\u7acb\u9a8c\u8bc1\u8be5\u7b49\u6570\u636e\uff0c\u4e0d\u80fd\u4fdd\u8bc1\u8be5\u7b49\u6570\u636e\u7684\u51c6\u786e\u6027\u6216\u5b8c\u6574\u6027\u3002\u8bf7\u9601\u4e0b\u6ce8\u610f\u4e0d\u8981\u8fc7\u5ea6\u8003\u8651\u8be5\u7b49\u6570\u636e\u3002\u8be5\u7b49\u6570\u636e\u6d89\u53ca\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\uff0c\u5e76\u53ef\u80fd\u6839\u636e\u5404\u79cd\u56e0\u7d20\uff08\u5305\u62ec\u524d\u8ff0\u56e0\u7d20\uff09\u6709\u6240\u66f4\u6539\u3002<\/p>\n

\u5185\u5e55\u6d88\u606f<\/p>\n

\u672c\u516c\u544a\u5305\u542b\uff08\u6b27\u76df\uff09\u7b2c596\/2014\u53f7\u6761\u4f8b\uff08\u8be5\u6761\u4f8b\u6784\u6210\u300a2018\u5e74\u6b27\u6d32\u8054\u76df\uff08\u9000\u51fa\uff09\u6cd5\u300b\u5b9a\u4e49\u7684\u6b27\u76df\u4fdd\u7559\u6cd5\u5f8b\u7684\u4e00\u90e8\u5206\uff09\u7b2c7\u6761\u89c4\u5b9a\u7684\u5185\u5e55\u6d88\u606f\u3002<\/p>\n

\u533b\u7597\u4fe1\u606f<\/p>\n

\u672c\u516c\u544a\u6240\u63d0\u5230\u7684\u4ea7\u54c1\u53ef\u80fd\u5e76\u672a\u5728\u6240\u6709\u56fd\u5bb6\u4e0a\u5e02\uff0c\u6216\u53ef\u80fd\u4ee5\u4e0d\u540c\u7684\u5546\u6807\u8fdb\u884c\u9500\u552e\uff0c\u6216\u7528\u4e8e\u4e0d\u540c\u7684\u75c5\u75c7\uff0c\u6216\u91c7\u7528\u4e0d\u540c\u7684\u5242\u91cf\uff0c\u6216\u62e5\u6709\u4e0d\u540c\u7684\u6548\u529b\u3002\u672c\u6587\u4e2d\u6240\u5305\u542b\u7684\u4efb\u4f55\u4fe1\u606f\u90fd\u4e0d\u5e94\u88ab\u89c6\u4e3a\u662f\u4efb\u4f55\u5904\u65b9\u836f\u7684\u7533\u8bf7\u3001\u63a8\u5e7f\u6216\u5e7f\u544a\uff0c\u5305\u62ec\u90a3\u4e9b\u6b63\u5728\u7814\u53d1\u7684\u836f\u7269\u3002<\/p>\n

\n

[1]\u00a0\u00a0 \u5e02\u573a\u9500\u552e\u989d = \u7531\u793c\u6765\uff08\u7231\u4f18\u7279\u00ae\uff09\u3001\u6b66\u7530\uff08FRUZAQLA\u00ae\uff09\u3001\u963f\u65af\u5229\u5eb7\uff08\u6c83\u745e\u6c99\u00ae\uff09\u53ca\u548c\u9ec4\u533b\u836f\uff08\u7231\u4f18\u7279\u00ae\u3001\u82cf\u6cf0\u8fbe\u00ae\u3001\u6c83\u745e\u6c99\u00ae\u53ca\u8fbe\u552f\u73c2\u00ae\uff09\u5411\u7b2c\u4e09\u65b9\u7684\u603b\u9500\u552e\u989d\u00a0<\/span><\/p>\n

[2]\u00a0 \u6b66\u7530\u00a0= Takeda Pharmaceuticals International AG\uff0cTakeda Pharmaceutical Company Limited\u7684\u9644\u5c5e\u516c\u53f8\u00a0<\/span><\/p>\n

[3]\u00a0\u00a0 \u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u00a0= \u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u6709\u9650\u516c\u53f8\u00a0(Shanghai Hutchison Pharmaceuticals Limited, SHPL)\u00a0<\/span><\/p>\n

[4]\u00a0 EGFR\u7a81\u53d8\u00a0= \u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7a81\u53d8\u9633\u6027\u00a0(Epidermal growth factor receptor mutated)\u00a0<\/span><\/p>\n

[5]\u00a0 \u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u00a0= Non-small cell lung cancer (NSCLC)\u00a0<\/span><\/p>\n

[6]\u00a0\u00a0 \u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u00a0= New Drug Application (NDA)\u00a0<\/span><\/p>\n

[7]\u00a0\u00a0 \u56fd\u5bb6\u836f\u76d1\u5c40\u00a0= \u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u00a0(China National Medical Products Administration, NMPA)\u00a0<\/span><\/p>\n

[8]\u00a0 \u963f\u65af\u5229\u5eb7\u00a0= AstraZeneca AB\uff0cAstraZeneca PLC\u7684\u9644\u5c5e\u516c\u53f8\u00a0\u00a0<\/span><\/p>\n

[9]\u00a0 \u4e8c\u7ebf\u00a0= Second-line (2L)<\/span><\/p>\n

[10]\u00a0 \u80be\u7ec6\u80de\u764c\u00a0= Renal cell carcinoma (RCC)\u00a0<\/span><\/p>\n

[11]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 ASH = \u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff09<\/span><\/p>\n

[12]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 EHA = \u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\u00a0(European Hematology Association)\u00a0<\/span><\/p>\n

[13]\u00a0 \u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u00a0= Immune thrombocytopenia purpura (ITP)\u00a0<\/span><\/p>\n

[14]\u00a0 \u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u00a0=\u00a0 Centre for Drug Evaluation (CDE)<\/span><\/p>\n

[15]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 ASCO = \u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u00a0(American Society of Clinical Oncology)\u00a0<\/span><\/p>\n

[16]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 pMMR = \u9519\u914d\u4fee\u590d\u5b8c\u6574\u00a0(Proficient mismatch repair)<\/span><\/p>\n

[17]\u00a0 \u5b50\u5bab\u5185\u819c\u764c\u00a0= Endometrial cancer (EMC)\u00a0<\/span><\/p>\n

[18]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 ATTC = \u6297\u4f53\u9776\u5411\u5076\u8054\u836f\u7269\uff08antibody-targeted therapy conjugates, ATTC\uff09<\/span><\/p>\n

[19]\u00a0 \u7814\u53d1\u00a0= \u7814\u7a76\u4e0e\u5f00\u53d1\u00a0(R&D)<\/span><\/p>\n

[20]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 EGFR = \u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u00a0(Epidermal growth factor receptor)\u00a0<\/span><\/p>\n

[21]\u00a0 TKI = \u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u00a0(Tyrosine kinase inhibitor)\u00a0<\/span><\/p>\n

[22]\u00a0 \u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840\u00a0= Autoimmune hemolytic anemia (AIHA)\u00a0<\/span><\/p>\n

[23]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u56fa\u5b9a\u6c47\u7387\u00a0= Constant exchange rate (CER)\u3002\u6211\u4eec\u4ea6\u62a5\u544a\u6309\u56fa\u5b9a\u6c47\u7387\u00a0(CER)\uff0c\u4e00\u79cd\u975eGAAP\u6307\u6807\uff0c\u8ba1\u7b97\u4e1a\u7ee9\u53d8\u5316\u3002\u8bf7\u53c2\u9605”\u975eGAAP\u8d22\u52a1\u6307\u6807\u7684\u4f7f\u7528\u548c\u8c03\u8282”\uff0c\u4ee5\u5206\u522b\u4e86\u89e3\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u7684\u89e3\u91ca\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u8d22\u52a1\u6307\u6807\u4e0e\u6700\u5177\u53ef\u6bd4\u6027\u7684GAAP\u6307\u6807\u7684\u5bf9\u8d26\u00a0<\/span><\/p>\n

[24]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u7ed3\u76f4\u80a0\u764c\u00a0= Colorectal cancer\uff08CRC\uff09<\/span><\/p>\n

[25]\u00a0 \u795e\u7ecf\u5185\u5206\u6ccc\u7624\u00a0= Neuroendocrine tumor (NET)\u00a0<\/span><\/p>\n

[26]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 MET\u5916\u663e\u5b5014\u8df3\u53d8\u00a0= MET exon 14 skipping alteration\u00a0 (METex14)\u00a0<\/span><\/p>\n

[27]\u00a0 \u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u00a0= \u300a\u4e2d\u56fd\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u300b(NRDL)\u00a0<\/span><\/p>\n

[28]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u4e00\u7ebf\u00a0= First-line (1L)<\/span><\/p>\n

[29]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u793c\u6765\u00a0= \u793c\u6765\u516c\u53f8\u00a0(Eli Lilly and Company)\u00a0<\/span><\/p>\n

[30]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u00a0= Supplemental New Drug Application (sNDA)\u00a0<\/span><\/p>\n

[31]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u4e09\u7ebf\u00a0= Third-line (3L)<\/span><\/p>\n

[32]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u590d\u53d1\/\u96be\u6cbb\u6027\u00a0= \u590d\u53d1\u53ca\/\u6216\u96be\u6cbb\u6027\u00a0(Relapsed and\/or refractory, R\/R)\u00a0<\/span><\/p>\n

[33]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 EZH2\u7a81\u53d8\u00a0= zeste\u57fa\u56e0\u589e\u5f3a\u5b50\u540c\u6e90\u72692\u7a81\u53d8\u00a0(Enhancer of zeste homolog 2 mutated)\u00a0<\/span><\/p>\n

[34]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 AACR =\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a(American Association for Cancer Research)\u00a0<\/span><\/p>\n

[35]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 ORR = \u5ba2\u89c2\u7f13\u89e3\u7387\u00a0(Objective response rate)\u00a0<\/span><\/p>\n

[36]\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 PFS = \u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u00a0(Progression-free survival)\u00a0<\/span><\/p>\n

[37]\u00a0 VEGFR = \u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u00a0(Vascular endothelial growth factor receptor)<\/span><\/p>\n

[38]\u00a0 IRC = \u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\u00a0(Independent review committee)<\/span><\/p>\n

[39]\u00a0 OS = \u603b\u751f\u5b58\u671f\u00a0(Overall survival)\u00a0<\/span><\/p>\n

[40]\u00a0 ASCO GI = \u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u7814\u8ba8\u4f1a\u00a0(ASCO Gastrointestinal Cancers Symposium)<\/span><\/p>\n

[41]\u00a0 \u764c\u80da\u6297\u539f\u00a0= Carcinoembryonic antigen (CEA)\u00a0<\/span><\/p>\n

[42]\u00a0 Syk =\u813e\u916a\u6c28\u9178\u6fc0\u9176\u00a0(Spleen tyrosine kinase)<\/span><\/p>\n

[43]\u00a0 FGFR =\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u00a0(Fibroblast growth factor receptor)<\/span><\/p>\n

[44]\u00a0 CSF-1R =\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u00a0-1 \u53d7\u4f53\u00a0(Colony-stimulating factor 1 receptor)\u00a0<\/span><\/p>\n

[45]\u00a0 \u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u00a0= Pancreatic ductal adenocarcinoma (PDAC)<\/span><\/p>\n

[46]\u00a0 \u809d\u5185\u80c6\u7ba1\u764c\u00a0= Intrahepatic cholangiocarcinoma (IHCC)\u00a0<\/span><\/p>\n

[47]\u00a0 IDH1 \u53ca IDH2 = \u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\u53ca\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-2 (Isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2)<\/span><\/p>\n

[48]\u00a0 IDH1\/2\u7a81\u53d8\u00a0= \u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\u6216\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-2\u7a81\u53d8\u00a0(Isocitrate dehydrogenase-1 OR isocitrate dehydrogenase-2 mutated, IDH1\/2m)<\/span><\/p>\n

[49]\u00a0 \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u00a0= Acute myeloid leukemia (AML)\u00a0<\/span><\/p>\n

[50]\u00a0 ERK = \u7ec6\u80de\u5916\u4fe1\u53f7\u8c03\u8282\u6fc0\u9176\u00a0(Extracellular signal-regulated kinase)\u00a0<\/span><\/p>\n

[51]\u00a0 BTK = \u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u00a0(Bruton’s tyrosine kinase)\u00a0<\/span><\/p>\n

[52]\u00a0 \u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u00a0= Investigational new drug application (IND)<\/span><\/p>\n

[53]\u00a0 \u521b\u54cd\u751f\u7269\u00a0= Inmagene Biopharmaceuticals\u00a0<\/span><\/p>\n

[54]\u00a0 EASI = \u6e7f\u75b9\u9762\u79ef\u548c\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\u00a0(Eczema area and severity index)\u00a0<\/span><\/p>\n

[55]\u00a0 \u5206\u9500\u4e1a\u52a1\u00a0= \u4e0a\u6d77\u548c\u8bb0\u9ec4\u57d4\u533b\u836f\u9500\u552e\u6709\u9650\u516c\u53f8\u00a0(Shanghai Hutchison Whampoa Pharmaceuticals Sales Limited)\uff0c\u524d\u79f0\u56fd\u836f\u63a7\u80a1\u548c\u8bb0\u9ec4\u57d4\u533b\u836f(\u4e0a\u6d77)\u6709\u9650\u516c\u53f8\u00a0(Hutchison Whampoa Sinopharm Pharmaceuticals (Shanghai) Company Limited)<\/span><\/p>\n

[56]\u00a0 \u9999\u6e2f\u4ea4\u6613\u6240\u00a0= \u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u00a0 (The Main Board of The Stock Exchange of Hong Kong Limited, HKEX)<\/span><\/p>\n

[57]\u00a0 ESG = \u73af\u5883\u3001\u793e\u4f1a\u53ca\u7ba1\u6cbb\u00a0(Environmental, Social and Governance)\u00a0<\/span><\/p>\n

[58]\u00a0 \u9500\u552e\u53ca\u884c\u653f\u5f00\u652f\u00a0= Selling and administrative expenses (S&A)\u00a0<\/span><\/p>\n

[59]\u00a0 ADS = \u7f8e\u56fd\u9884\u6258\u8bc1\u5238\u00a0(American depositary share)\u00a0<\/span><\/p>\n

[60]\u00a0 GAAP = \u4e00\u822c\u516c\u8ba4\u4f1a\u8ba1\u539f\u5219\u00a0(Generally Accepted Accounting Principles)\u00a0<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

SOURCE \u548c\u9ec4\u533b\u836f(\u4e2d\u56fd)\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"

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“\u6211\u4eec\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u836f\u7269\u53d6\u5f97\u4e86\u65b0\u7684\u91cc\u7a0b\u7891\uff0c\u5e76\u7ee7\u7eed\u6269\u5927\u4e34\u5e8a\u5f00\u53d1\u7248\u56fe\uff0c\u60e0\u53ca\u5168\u7403\u66f4\u591a\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u544b\u55b9\u66ff\u5c3c\u73b0\u5df2\u5728\u5341\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u672a\u6765\u5c06\u6269\u5c55\u81f3\u66f4\u591a\u5730\u533a\u3002FRUZAQLA\u00ae\u4e0a\u5e02\u4ec5\u4e00\u5e74\u5185\u9500\u552e\u989d\u5c31\u5df2\u7a81\u78342\u4ebf\u7f8e\u5143\uff0c\u89e6\u53d1\u9996\u4e2a\u9500\u552e\u91cc\u7a0b\u7891\u3002\u5728\u4e2d\u56fd\uff0c\u8be5\u836f\u7269\u8fd8\u83b7\u6279\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\uff0c\u5e73\u5747\u7528\u836f\u65f6\u95f4\u662f\u5176\u9996\u4e2a\u9002\u5e94\u75c7\u7684\u5c06\u8fd1\u4e24\u500d\uff0c\u800c\u7b2c\u4e09\u9879\u7528\u4e8e\u6cbb\u7597\u80be\u764c\u7684FRUSICA-2\u6ce8\u518c\u7814\u7a76\u4ea6\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002” “\u81f3\u4e8e\u8d5b\u6c83\u66ff\u5c3c\uff0c\u57fa\u4e8eSACHI\u7814\u7a76\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebfEGFR[20] TKI[21]\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u4f34\u6709MET\u6269\u589e\u60a3\u8005\u7684\u4e2d\u671f\u5206\u6790\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u6211\u4eec\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff0c\u8be5\u7533\u8bf7\u5df2\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u6211\u4eec\u671f\u5f85SAVANNAH\/SAFFRON\u7814\u7a76\u5c06\u652f\u6301\u628a\u8fd9\u79cd\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u7403\u7684\u60a3\u8005\u3002\u8fd1\u671f\uff0c\u968f\u7740\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8\u80ba\u764c\u5747\u53d6\u5f97\u5e38\u89c4\u6279\u51c6\uff0c\u8d5b\u6c83\u66ff\u5c3c\u4ecd\u7136\u662f\u540c\u7c7b\u6700\u4f73\u836f\u7269\u4e4b\u4e00\u3002\u4e00\u9879\u5728MET\u6269\u589e\u80c3\u764c\u4e2d\u5f00\u5c55\u7684\u6ce8\u518c\u610f\u5411\u7814\u7a76\u73b0\u6b63\u5728\u4e2d\u56fd\u5165\u7ec4\u4e2d\u3002\u6211\u4eec\u671f\u5f85\u6709\u671b\u8fdb\u4e00\u6b65\u6269\u5c55\u5176\u9002\u5e94\u75c7\uff0c\u4ee5\u6210\u4e3a\u9996\u4e2a\u7528\u4e8e\u4f34\u6709MET\u6269\u589e\u3001EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53ca\u80c3\u764c\u7684\u836f\u7269\u3002\u6211\u4eec\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u5c06\u7ee7\u7eed\u652f\u6301\u548c\u9ec4\u533b\u836f\u7684\u6536\u5165\u548c\u76c8\u5229\u589e\u957f\u3002” “\u7d22\u4e50\u5339\u5c3c\u5e03ESLIM-01\u7814\u7a76\u7684\u6570\u636e\u4e8eEHA\u53caASH\u5e74\u4f1a\u516c\u5e03\uff0c\u6301\u7eed\u5e94\u7b54\u7387\u8fbe51.4%\uff0c\u6574\u4f53\u5e94\u7b54\u7387\u8fbe81.0%\uff0c\u663e\u8457\u4f18\u4e8e\u591a\u79cd\u6b63\u5728\u7814\u53d1\u7684\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u836f\u7269\u3002\u7d22\u4e50\u5339\u5c3c\u5e03\u7684\u8fd9\u4e9b\u4e34\u5e8a\u7ed3\u679c\u518d\u6b21\u5f70\u663e\u548c\u9ec4\u533b\u836f\u5728\u9009\u62e9\u6027\u65b9\u9762\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u4ece\u800c\u5e26\u6765\u7406\u60f3\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u6211\u4eec\u6b63\u4e0e\u56fd\u5bb6\u836f\u76d1\u5c40\u7d27\u5bc6\u6c9f\u901a\uff0c\u671f\u5f85\u5c06\u8fd9\u79cd\u521b\u65b0\u836f\u7269\u5e26\u7ed9\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840[22]\u60a3\u8005\u7684ESLIM-02 III\u671f\u6ce8\u518c\u7814\u7a76\u6b63\u5728\u5165\u7ec4\u4e2d\uff0c\u9884\u8ba1\u660e\u5e74\u516c\u5e03\u7ed3\u679c\u3002\u4e00\u9879\u4ed6\u6cfd\u53f8\u4ed6\uff08tazemetostat\uff09\u7528\u4e8e\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u6b63\u5728\u5ba1\u8bc4\u4e2d\uff0c\u9884\u8ba12025\u5e74\u5e74\u4e2d\u83b7\u6279\u3002\u6211\u4eec\u671f\u5f85\u80fd\u591f\u5c06\u7d22\u4e50\u5339\u5c3c\u5e03\u548c\u4ed6\u6cfd\u53f8\u4ed6\u7eb3\u5165\u5546\u4e1a\u5316\u4ea7\u54c1\u7ec4\u5408\uff0c\u4e3a\u548c\u9ec4\u533b\u836f\u7684\u6301\u7eed\u589e\u957f\u505a\u51fa\u8d21\u732e\u3002” 2024\u5e74\u5168\u5e74\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55 I.\u5546\u4e1a\u8425\u8fd0 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[…]<\/p>\n","protected":false},"author":0,"featured_media":8682,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-8681","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"\n\u548c\u9ec4\u533b\u836f\u516c\u5e032024\u5e74\u5168\u5e74\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u548c\u9ec4\u533b\u836f\u516c\u5e032024\u5e74\u5168\u5e74\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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ASCO[15]\u5e74\u4f1a\u516c\u5e03\uff0c\u57fa\u4e8e\u8be5\u7ed3\u679c\u56fd\u5bb6\u836f\u76d1\u5c40\u5df2\u6279\u51c6\u7231\u4f18\u7279\u00ae\uff08ELUNATE\u00ae\uff0c\u544b\u55b9\u66ff\u5c3c\uff09\u7684\u7b2c\u4e8c\u9879\u9002\u5e94\u75c7\uff0c\u4ee5\u7528\u4e8e\u6cbb\u7597pMMR\u00a0[16]\u72b6\u6001\u7684\u5b50\u5bab\u5185\u819c\u764c[17]\u60a3\u8005\u3002\u00a0\u5168\u65b0\u00a0ATTC[18]\u5e73\u53f0\u7684\u9996\u6279\u5019\u9009\u836f\u7269\u5f00\u542f\u65b0\u4e00\u6ce2\u5019\u9009\u836f\u7269\u5f00\u53d1\u6d6a\u6f6e\uff0c\u6709\u671b\u8f83\u524d\u51e0\u4ee3\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\u62e5\u6709\u66f4\u9ad8\u7684\u9009\u62e9\u6027\u53ca\u8010\u53d7\u6027\u3002 \u548c\u9ec4\u533b\u836f\u975e\u6267\u884c\u4e3b\u5e2d\u827e\u4e50\u5fb7\u535a\u58eb\uff08Dr Dan Eldar\uff09\u8868\u793a\uff1a”\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34\u6b66\u7530\u6210\u529f\u63a8\u52a8FRUZAQLA\u00ae\u5728\u4e2d\u56fd\u5883\u5916\u5546\u4e1a\u5316\uff0c\u5e76\u5728\u4eca\u5e74\u8fbe\u6210\u4e00\u7cfb\u5217\u91cc\u7a0b\u7891\uff0c\u4e3a\u548c\u9ec4\u533b\u836f\u5b9e\u73b0\u76c8\u5229\u7684\u76ee\u6807\u63d0\u4f9b\u4e86\u91cd\u8981\u52a9\u529b\u3002\u6211\u611f\u5230\u76f8\u5f53\u81ea\u8c6a\uff0c\u6211\u4eec\u80fd\u591f\u5728\u5168\u7403\u73af\u5883\u548c\u8d44\u672c\u5e02\u573a\u5145\u6ee1\u4e0d\u786e\u5b9a\u6027\u7684\u60c5\u51b5\u4e0b\uff0c\u4e0d\u4ec5\u6210\u529f\u5efa\u7acb\u4e86\u81ea\u7acb\u80fd\u529b\u4ee5\u652f\u6301\u6211\u4eec\u91cd\u8981\u7684\u836f\u7269\u53d1\u73b0\u5f15\u64ce\u548c\u5f00\u53d1\u7ba1\u7ebf\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u8fd8\u540c\u65f6\u964d\u4f4e\u4e86\u8fd0\u8425\u98ce\u9669\u3002\u968f\u7740\u7f8e\u56fd\u548c\u4e16\u754c\u5176\u4ed6\u5730\u533a\u7684\u9500\u552e\u8fdb\u4e00\u6b65\u6269\u5c55\uff0c\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u4fdd\u6301\u5168\u7403\u589e\u957f\uff0c\u5e76\u7ee7\u7eed\u5728\u65b0\u7684\u548c\u5177\u6709\u524d\u666f\u7684\u65b9\u5411\u4e0a\u63a8\u8fdb\u6211\u4eec\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u6211\u4eec\u59cb\u7ec8\u5c06\u7ef4\u62a4\u80a1\u4e1c\u7684\u957f\u671f\u5229\u76ca\u4ee5\u53ca\u5168\u7403\u60a3\u8005\u7684\u798f\u7949\u4f5c\u4e3a\u6211\u4eec\u7684\u9996\u8981\u4efb\u52a1\u3002” “2024\u5e74\u5e74\u5e95\uff0c\u6211\u4eec\u51b3\u5b9a\u4ee56.08\u4ebf\u7f8e\u5143\u51fa\u552e\u5728\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a45%\u7684\u80a1\u6743\uff08\u53d6\u51b3\u4e8e\u6210\u4ea4\u6761\u4ef6\uff09\u3002\u6211\u60f3\u501f\u6b64\u673a\u4f1a\u5411\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u7684\u7ba1\u7406\u56e2\u961f\u8868\u793a\u611f\u8c22\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u5e26\u9886\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u5728\u8fc7\u53bb20\u5e74\u95f4\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u589e\u957f\uff0c\u4e3a\u6d88\u8d39\u8005\u548c\u80a1\u4e1c\u5e26\u6765\u4e86\u6301\u7eed\u7684\u83b7\u76ca\u3002\u5176\u6210\u529f\u7684\u5546\u4e1a\u5316\u7ecf\u9a8c\u4ee5\u53ca\u6240\u8d21\u732e\u7684\u8d44\u91d1\u4e3a\u548c\u9ec4\u533b\u836f\u4ece\u4e8b\u65b0\u836f\u7814\u53d1[19]\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u652f\u6301\uff0c\u5e2e\u52a9\u6211\u4eec\u5728\u5f00\u53d1\u521b\u65b0\u836f\u7269\u4ee5\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\u7684\u8fc7\u7a0b\u4e2d\u5e94\u5bf9\u884c\u4e1a\u6311\u6218\u3002\u968f\u7740\u6211\u4eec\u7684\u521b\u65b0\u836f\u4e1a\u52a1\u9010\u6e10\u8d70\u5411\u81ea\u7ed9\u81ea\u8db3\uff0c\u7279\u522b\u662f\u968f\u7740\u6211\u4eec\u5c06\u66f4\u591a\u7684\u6ce8\u610f\u529b\u8f6c\u5411ATTC\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\uff0c\u6211\u4eec\u76f8\u4fe1\u73b0\u5728\u662f\u65f6\u5019\u5e26\u9886\u548c\u9ec4\u533b\u836f\u8fc8\u5165\u4e0b\u4e00\u4e2a\u53d1\u5c55\u9636\u6bb5\u3002\u51fa\u552e\u4e0a\u6d77\u548c\u9ec4\u836f\u4e1a\u6240\u5f97\u6b3e\u9879\uff0c\u518d\u52a0\u4e0a\u4ea7\u54c1\u5168\u7403\u5546\u4e1a\u5316\u5e26\u6765\u7684\u6301\u7eed\u5229\u6da6\uff0c\u4f7f\u6211\u4eec\u5f97\u4ee5\u52a0\u901f\u63a8\u8fdb\u8fd9\u4e00\u5dee\u5f02\u5316\u7684\u65b0\u6280\u672f\u5e73\u53f0\u7684\u53d1\u5c55\uff0c\u5e76\u5c06\u6210\u4e3a\u6211\u4eec\u521b\u9020\u957f\u671f\u4ef7\u503c\u7684\u5173\u952e\u3002” \u548c\u9ec4\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u82cf\u6170\u56fd\u535a\u58eb\u8868\u793a\uff1a”\u4eca\u5e74\u662f\u6210\u679c\u4e30\u7855\u7684\u4e00\u5e74\uff0c\u6211\u4eec\u5177\u6709\u9769\u547d\u6027\u7684\u521b\u65b0\u7597\u6cd5\u65e0\u8bba\u662f\u5728\u4e34\u5e8a\u6216\u662f\u5728\u5546\u4e1a\u5316\u65b9\u9762\u5747\u5b9e\u73b0\u4e86\u6211\u4eec\u7684\u6218\u7565\u76ee\u6807\u3002\u8fd9\u7ec8\u4e8e\u4ee4\u548c\u9ec4\u533b\u836f\u5b9e\u73b0\u76c8\u5229\u8fd9\u4e00\u91cd\u8981\u76ee\u6807\u3002\u6211\u8877\u5fc3\u611f\u8c22\u5e76\u795d\u8d3a\u56e2\u961f\u8fbe\u6210\u8fd9\u4e00\u91cc\u7a0b\u7891\uff0c\u63a5\u4e0b\u6765\u6211\u4eec\u5c06\u628a\u6ce8\u610f\u529b\u6295\u5165\u5230\u8fdb\u4e00\u6b65\u7684\u589e\u957f\uff0c\u5e76\u901a\u8fc7\u6211\u4eec\u7684ATTC\u5e73\u53f0\u5b55\u80b2\u548c\u9ec4\u533b\u836f\u7684\u4e0b\u4e00\u6ce2\u521b\u65b0\u836f\u7269\u3002” “\u5f00\u521b\u6027\u7684ATTC\u5e73\u53f0\u4e3a\u548c\u9ec4\u533b\u836f\u7684\u521b\u65b0\u836f\u7814\u53d1\u65c5\u7a0b\u63ed\u5f00\u65b0\u7684\u7bc7\u7ae0\uff0c\u5728\u6297\u4f53\u5076\u8054\u836f\u7269\u9886\u57df\u5f00\u8f9f\u65b0\u7684\u65b9\u5411\u3002\u8fd9\u4e9b\u521b\u65b0\u5206\u5b50\u5177\u6709\u6f5c\u529b\u5e7f\u6cdb\u8986\u76d6\u591a\u79cd\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\uff0c\u8574\u542b\u5e9e\u5927\u7684\u5e02\u573a\u6f5c\u80fd\u3002\u51ed\u501f\u5728\u5168\u7403\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u9762\u7684\u4e13\u4e1a\u5b9e\u529b\u4ee5\u53ca\u8d44\u91d1\u4f18\u52bf\uff0c\u6211\u4eec\u8ba1\u5212\u5728\u4eca\u5e74\u8fc5\u901f\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002” “\u6211\u4eec\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u836f\u7269\u53d6\u5f97\u4e86\u65b0\u7684\u91cc\u7a0b\u7891\uff0c\u5e76\u7ee7\u7eed\u6269\u5927\u4e34\u5e8a\u5f00\u53d1\u7248\u56fe\uff0c\u60e0\u53ca\u5168\u7403\u66f4\u591a\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u544b\u55b9\u66ff\u5c3c\u73b0\u5df2\u5728\u5341\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u672a\u6765\u5c06\u6269\u5c55\u81f3\u66f4\u591a\u5730\u533a\u3002FRUZAQLA\u00ae\u4e0a\u5e02\u4ec5\u4e00\u5e74\u5185\u9500\u552e\u989d\u5c31\u5df2\u7a81\u78342\u4ebf\u7f8e\u5143\uff0c\u89e6\u53d1\u9996\u4e2a\u9500\u552e\u91cc\u7a0b\u7891\u3002\u5728\u4e2d\u56fd\uff0c\u8be5\u836f\u7269\u8fd8\u83b7\u6279\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\uff0c\u5e73\u5747\u7528\u836f\u65f6\u95f4\u662f\u5176\u9996\u4e2a\u9002\u5e94\u75c7\u7684\u5c06\u8fd1\u4e24\u500d\uff0c\u800c\u7b2c\u4e09\u9879\u7528\u4e8e\u6cbb\u7597\u80be\u764c\u7684FRUSICA-2\u6ce8\u518c\u7814\u7a76\u4ea6\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002” “\u81f3\u4e8e\u8d5b\u6c83\u66ff\u5c3c\uff0c\u57fa\u4e8eSACHI\u7814\u7a76\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebfEGFR[20] TKI[21]\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u4f34\u6709MET\u6269\u589e\u60a3\u8005\u7684\u4e2d\u671f\u5206\u6790\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u6211\u4eec\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff0c\u8be5\u7533\u8bf7\u5df2\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u6211\u4eec\u671f\u5f85SAVANNAH\/SAFFRON\u7814\u7a76\u5c06\u652f\u6301\u628a\u8fd9\u79cd\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u7403\u7684\u60a3\u8005\u3002\u8fd1\u671f\uff0c\u968f\u7740\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8\u80ba\u764c\u5747\u53d6\u5f97\u5e38\u89c4\u6279\u51c6\uff0c\u8d5b\u6c83\u66ff\u5c3c\u4ecd\u7136\u662f\u540c\u7c7b\u6700\u4f73\u836f\u7269\u4e4b\u4e00\u3002\u4e00\u9879\u5728MET\u6269\u589e\u80c3\u764c\u4e2d\u5f00\u5c55\u7684\u6ce8\u518c\u610f\u5411\u7814\u7a76\u73b0\u6b63\u5728\u4e2d\u56fd\u5165\u7ec4\u4e2d\u3002\u6211\u4eec\u671f\u5f85\u6709\u671b\u8fdb\u4e00\u6b65\u6269\u5c55\u5176\u9002\u5e94\u75c7\uff0c\u4ee5\u6210\u4e3a\u9996\u4e2a\u7528\u4e8e\u4f34\u6709MET\u6269\u589e\u3001EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53ca\u80c3\u764c\u7684\u836f\u7269\u3002\u6211\u4eec\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u5c06\u7ee7\u7eed\u652f\u6301\u548c\u9ec4\u533b\u836f\u7684\u6536\u5165\u548c\u76c8\u5229\u589e\u957f\u3002” “\u7d22\u4e50\u5339\u5c3c\u5e03ESLIM-01\u7814\u7a76\u7684\u6570\u636e\u4e8eEHA\u53caASH\u5e74\u4f1a\u516c\u5e03\uff0c\u6301\u7eed\u5e94\u7b54\u7387\u8fbe51.4%\uff0c\u6574\u4f53\u5e94\u7b54\u7387\u8fbe81.0%\uff0c\u663e\u8457\u4f18\u4e8e\u591a\u79cd\u6b63\u5728\u7814\u53d1\u7684\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u836f\u7269\u3002\u7d22\u4e50\u5339\u5c3c\u5e03\u7684\u8fd9\u4e9b\u4e34\u5e8a\u7ed3\u679c\u518d\u6b21\u5f70\u663e\u548c\u9ec4\u533b\u836f\u5728\u9009\u62e9\u6027\u65b9\u9762\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u4ece\u800c\u5e26\u6765\u7406\u60f3\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u6211\u4eec\u6b63\u4e0e\u56fd\u5bb6\u836f\u76d1\u5c40\u7d27\u5bc6\u6c9f\u901a\uff0c\u671f\u5f85\u5c06\u8fd9\u79cd\u521b\u65b0\u836f\u7269\u5e26\u7ed9\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840[22]\u60a3\u8005\u7684ESLIM-02 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“\u5f00\u521b\u6027\u7684ATTC\u5e73\u53f0\u4e3a\u548c\u9ec4\u533b\u836f\u7684\u521b\u65b0\u836f\u7814\u53d1\u65c5\u7a0b\u63ed\u5f00\u65b0\u7684\u7bc7\u7ae0\uff0c\u5728\u6297\u4f53\u5076\u8054\u836f\u7269\u9886\u57df\u5f00\u8f9f\u65b0\u7684\u65b9\u5411\u3002\u8fd9\u4e9b\u521b\u65b0\u5206\u5b50\u5177\u6709\u6f5c\u529b\u5e7f\u6cdb\u8986\u76d6\u591a\u79cd\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u4f5c\u4e3a\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\uff0c\u8574\u542b\u5e9e\u5927\u7684\u5e02\u573a\u6f5c\u80fd\u3002\u51ed\u501f\u5728\u5168\u7403\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u9762\u7684\u4e13\u4e1a\u5b9e\u529b\u4ee5\u53ca\u8d44\u91d1\u4f18\u52bf\uff0c\u6211\u4eec\u8ba1\u5212\u5728\u4eca\u5e74\u8fc5\u901f\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002” “\u6211\u4eec\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u836f\u7269\u53d6\u5f97\u4e86\u65b0\u7684\u91cc\u7a0b\u7891\uff0c\u5e76\u7ee7\u7eed\u6269\u5927\u4e34\u5e8a\u5f00\u53d1\u7248\u56fe\uff0c\u60e0\u53ca\u5168\u7403\u66f4\u591a\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u544b\u55b9\u66ff\u5c3c\u73b0\u5df2\u5728\u5341\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u672a\u6765\u5c06\u6269\u5c55\u81f3\u66f4\u591a\u5730\u533a\u3002FRUZAQLA\u00ae\u4e0a\u5e02\u4ec5\u4e00\u5e74\u5185\u9500\u552e\u989d\u5c31\u5df2\u7a81\u78342\u4ebf\u7f8e\u5143\uff0c\u89e6\u53d1\u9996\u4e2a\u9500\u552e\u91cc\u7a0b\u7891\u3002\u5728\u4e2d\u56fd\uff0c\u8be5\u836f\u7269\u8fd8\u83b7\u6279\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\uff0c\u5e73\u5747\u7528\u836f\u65f6\u95f4\u662f\u5176\u9996\u4e2a\u9002\u5e94\u75c7\u7684\u5c06\u8fd1\u4e24\u500d\uff0c\u800c\u7b2c\u4e09\u9879\u7528\u4e8e\u6cbb\u7597\u80be\u764c\u7684FRUSICA-2\u6ce8\u518c\u7814\u7a76\u4ea6\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002” “\u81f3\u4e8e\u8d5b\u6c83\u66ff\u5c3c\uff0c\u57fa\u4e8eSACHI\u7814\u7a76\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebfEGFR[20] TKI[21]\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u4f34\u6709MET\u6269\u589e\u60a3\u8005\u7684\u4e2d\u671f\u5206\u6790\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u6211\u4eec\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff0c\u8be5\u7533\u8bf7\u5df2\u83b7\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u6211\u4eec\u671f\u5f85SAVANNAH\/SAFFRON\u7814\u7a76\u5c06\u652f\u6301\u628a\u8fd9\u79cd\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u7403\u7684\u60a3\u8005\u3002\u8fd1\u671f\uff0c\u968f\u7740\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597MET\u5916\u663e\u5b5014\u8df3\u53d8\u80ba\u764c\u5747\u53d6\u5f97\u5e38\u89c4\u6279\u51c6\uff0c\u8d5b\u6c83\u66ff\u5c3c\u4ecd\u7136\u662f\u540c\u7c7b\u6700\u4f73\u836f\u7269\u4e4b\u4e00\u3002\u4e00\u9879\u5728MET\u6269\u589e\u80c3\u764c\u4e2d\u5f00\u5c55\u7684\u6ce8\u518c\u610f\u5411\u7814\u7a76\u73b0\u6b63\u5728\u4e2d\u56fd\u5165\u7ec4\u4e2d\u3002\u6211\u4eec\u671f\u5f85\u6709\u671b\u8fdb\u4e00\u6b65\u6269\u5c55\u5176\u9002\u5e94\u75c7\uff0c\u4ee5\u6210\u4e3a\u9996\u4e2a\u7528\u4e8e\u4f34\u6709MET\u6269\u589e\u3001EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53ca\u80c3\u764c\u7684\u836f\u7269\u3002\u6211\u4eec\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u5c06\u7ee7\u7eed\u652f\u6301\u548c\u9ec4\u533b\u836f\u7684\u6536\u5165\u548c\u76c8\u5229\u589e\u957f\u3002” “\u7d22\u4e50\u5339\u5c3c\u5e03ESLIM-01\u7814\u7a76\u7684\u6570\u636e\u4e8eEHA\u53caASH\u5e74\u4f1a\u516c\u5e03\uff0c\u6301\u7eed\u5e94\u7b54\u7387\u8fbe51.4%\uff0c\u6574\u4f53\u5e94\u7b54\u7387\u8fbe81.0%\uff0c\u663e\u8457\u4f18\u4e8e\u591a\u79cd\u6b63\u5728\u7814\u53d1\u7684\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u836f\u7269\u3002\u7d22\u4e50\u5339\u5c3c\u5e03\u7684\u8fd9\u4e9b\u4e34\u5e8a\u7ed3\u679c\u518d\u6b21\u5f70\u663e\u548c\u9ec4\u533b\u836f\u5728\u9009\u62e9\u6027\u65b9\u9762\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u4ece\u800c\u5e26\u6765\u7406\u60f3\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u6211\u4eec\u6b63\u4e0e\u56fd\u5bb6\u836f\u76d1\u5c40\u7d27\u5bc6\u6c9f\u901a\uff0c\u671f\u5f85\u5c06\u8fd9\u79cd\u521b\u65b0\u836f\u7269\u5e26\u7ed9\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7528\u4e8e\u6cbb\u7597\u6e29\u6297\u4f53\u578b\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840[22]\u60a3\u8005\u7684ESLIM-02 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