{"id":9218,"date":"2025-03-30T11:10:00","date_gmt":"2025-03-30T11:10:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e5%9c%a82025%e5%b9%b4%e4%ba%9a%e5%a4%aa%e8%82%9d%e7%97%85%e5%ad%a6%e4%bc%9a%e5%b9%b4%e4%bc%9a%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e5%b8%83%e5%85%b6%e6%ad%a3\/"},"modified":"2025-03-30T11:10:00","modified_gmt":"2025-03-30T11:10:00","slug":"%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e5%9c%a82025%e5%b9%b4%e4%ba%9a%e5%a4%aa%e8%82%9d%e7%97%85%e5%ad%a6%e4%bc%9a%e5%b9%b4%e4%bc%9a%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e5%b8%83%e5%85%b6%e6%ad%a3","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e5%9c%a82025%e5%b9%b4%e4%ba%9a%e5%a4%aa%e8%82%9d%e7%97%85%e5%ad%a6%e4%bc%9a%e5%b9%b4%e4%bc%9a%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e5%b8%83%e5%85%b6%e6%ad%a3\/","title":{"rendered":"\u817e\u76db\u535a\u836f\u57282025\u5e74\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\u5e74\u4f1a\uff08APASL\uff09\u4e0a\u516c\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u65b0\u6570\u636e\uff0c\u8868\u660eBRII-179\u6709\u671b\u901a\u8fc7\u76ee\u6807\u60a3\u8005\u8bc6\u522b\u63d0\u9ad8HBsAg\u6e05\u9664\u7387"},"content":{"rendered":"<p>ENSURE\u7814\u7a76\u961f\u52174\u7684\u521d\u6b65\u6570\u636e\u652f\u6301\u4e00\u9879\u65b0\u9896\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u5229\u7528BRII-179\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u60a3\u8005\uff0c\u4f7f\u5176\u6709\u671b\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff08EOT\uff09\u5b9e\u73b0\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387ENSURE\u7814\u7a76\u961f\u52171-3\u768448\u5468EOT\u6570\u636e\u6e05\u695a\u8868\u660e\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u53ef\u5b9e\u73b0\u989d\u5916\u83b7\u76ca\uff0c\u8fbe\u5230\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387<\/p>\n<p><span 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IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002\u5728\u5148\u524d\u7684\u4e9a\u592a\u5730\u533a\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u8fc79\u5242BRII-179\uff08\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u8054\u5408elebsiran\uff08BRII-835\uff09\u7ed9\u836f\u7684\u53c2\u4e0e\u8005\u88ab\u7eb3\u5165\u8be5\u7814\u7a76\u7684\u961f\u52174\uff0c\u5e76\u63a5\u53d7elebsiran\u548cPEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u3002\u672c\u7814\u7a76\u961f\u52174\u7684\u8bbe\u8ba1\u57fa\u4e8e\u65e2\u5f80\u7814\u7a76\u7684\u89c1\u89e3\uff0c\u5373\u5f88\u5927\u4e00\u90e8\u5206\u6162\u6027HBV\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u6027\u75ab\u82d7\u7684\u591a\u6b21\u6cbb\u7597\u540e\u672a\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u56e0\u6b64\u4e0d\u592a\u53ef\u80fd\u83b7\u5f97\u514d\u75ab\u652f\u6301\u4ee5\u5b9e\u73b0\u6301\u4e45\u7684\u529f\u80fd\u6027\u6cbb\u6108\u3002<\/p>\n<p>\u961f\u52174\u7684\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c\u8fc7\u5f80\u4ea7\u751fBRII-179\u8bf1\u5bfc\u7684\u4e59\u809d\u8868\u9762\u6297\u4f53\uff08\u6297-HBs\uff09\u5e94\u7b54\u7684\u53c2\u4e0e\u8005\uff0c\u5176HBsAg\u8840\u6e05\u6e05\u9664\u7387\u663e\u8457\u9ad8\u4e8e\u672a\u4ea7\u751f\u5e94\u7b54\u7684\u53c2\u4e0e\u8005\u3002\u7b2c24\u5468\u65f6\uff0c\u8d85\u8fc7\u534a\u6570\u7684BRII-179\u5e94\u7b54\u8005\uff0855.6% [10\/18]\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u53ea\u670910.0%\uff081\/10\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u672c\u6b21\u516c\u5e03\u7684\u6570\u636e\u8868\u660e\uff0cBRII-179\u6709\u6f5c\u529b\u6210\u4e3a\u4e00\u79cd\u9884\u6d4b\u5de5\u5177\uff0c\u7528\u4e8e\u7b5b\u9009\u51fa\u66f4\u53ef\u80fd\u5bf9\u6cbb\u6108\u65b9\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u3002<\/p>\n<p>\u6b64\u6b21\u516c\u5e03\u7684ENSURE\u7814\u7a76\u4e2d\u961f\u52171-3\u989d\u5916\u6570\u636e\u663e\u793a\uff0c\u4e0e\u63a5\u53d7PEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u5728\u6cbb\u7597\u7ed3\u675f (EOT) 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IU\/mL\u7684\u53c2\u4e0e\u8005\u88ab\u7eb3\u5165\u5206\u6790\u3002\u5176\u4e2d\uff0c18\u4f8b\u901a\u8fc7\u5148\u524dBRII-179\u6cbb\u7597\u8bf1\u5bfc\u7684\u6297-HBs\u5cf0\u503c\u226510 IU\/L\u7684\u53d7\u8bd5\u8005\u88ab\u5b9a\u4e49\u4e3aBRII-179\u5e94\u7b54\u8005\uff0c10\u4f8b\u6297-HBs\u5cf0\u503c&lt;10 IU\/L\u7684\u53d7\u8bd5\u8005\u88ab\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\u3002\u5728elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u7b2c24\u5468\u65f6\uff0c\u961f\u52174\u53c2\u4e0e\u8005\u4e2d\u670939.3%\uff0811\/28\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u7b2c24\u5468\u65f6\uff0cBRII-179\u5e94\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u4e3a55.6%\uff0810\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\u768410%\uff081\/10\uff09\u3002\u4e0e\u6b64\u524d\u62a5\u544a\u7684\u63a5\u53d7elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u4f46\u672a\u7ecfBRII-179\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u65e2\u5f80\u63a5\u53d7BRII-179\u6cbb\u7597\u7684\u5e94\u7b54\u8005\u4f3c\u4e4e\u53ef\u4ee5\u5b9e\u73b0\u66f4\u5feb\u7684HBsAg\u8840\u6e05\u6e05\u9664\u3002\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002Elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u4f1a\u6301\u7eed48\u5468\u3002<\/p>\n<p>\u6458\u8981\u7f16\u53f7\uff1aLB0009<\/p>\n<p>\u62a5\u544a\u6807\u9898\uff1a\u4e0e\u5355\u7528\u00a0PEG-IFN\u03b1 \u76f8\u6bd4\uff0c\u63a5\u53d7 elebsiran \u548cPEG-IFN\u03b1\u6cbb\u7597\u7684\u6162\u6027 HBV \u611f\u67d3\u8005\u5728\u6cbb\u7597\u7ed3\u675f (EOT) \u65f6 HBsAg \u6e05\u9664\u7387\u548c\u8840\u6e05\u8f6c\u6362\u7387\u66f4\u9ad8\uff1a \u6b63\u5728\u8fdb\u884c\u7684ENSURE\u7814\u7a76\u7b2c48\u5468\u7ed3\u679c<\/p>\n<p>\u4e3b\u8bb2\u4eba\uff1a\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0cM.D.\uff0cPh.D.\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u4e2d\u56fd\u5317\u4eac<\/p>\n<p>EOT\u65f6\uff0c\u5728\u57fa\u7ebfHBsAg\u6c34\u5e73\u4e3a100-3,000 IU\/mL\u7684\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran 200 mg + PEG-IFN\u03b1\u961f\u5217\u548celebsiran 100 mg + PEG-IFN\u03b1\u961f\u5217\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u5206\u522b\u4e3a26.3%\uff085\/19\uff09\u548c33.3%\uff086\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8ePEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u961f\u5217\uff085.6%\uff09\u3002\u4e0ePEG-IFN\u03b1\u961f\u5217\uff08-1.02 [0.30] log10 IU\/mL\uff09\u76f8\u6bd4\uff0celebsiran + PEG-IFN\u03b1\u961f\u5217\u5728EOT\u65f6\u7684HBsAg\u4e0b\u964d\u5e45\u5ea6\u66f4\u5927\uff08\u5e73\u5747\u503c[SE]\uff1aelebsiran 200 mg\u6216100 mg\u5206\u522b\u4e3a-2.47 [0.28]\u6216-3.01 [0.28] log10 IU\/mL\uff09\u3002Elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\uff08\u5242\u91cf\u5206\u522b\u4e3a200 mg\u548c100 mg\uff09\uff0c\u5728HBsAg\u4e0b\u964d\u5e45\u5ea6\u548c\u8840\u6e05\u6e05\u9664\u7387\u65b9\u9762\u5747\u8868\u73b0\u51fa\u76f8\u4f3c\u7684\u6548\u679c\u3002\u5728\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u7597\u6cd5\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002\u6cbb\u7597\u540e\u968f\u8bbf\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u5e76\u5c06\u6301\u7eed\u968f\u8bbf\u81f3\u6cbb\u7597\u7ec8\u6b62\u540e\u7b2c24\u5468\u3002<\/p>\n<p>\u4f5c\u4e3a\u817e\u76db\u535a\u836f\u5f00\u53d1HBV\u529f\u80fd\u6027\u6cbb\u6108\u7684\u72ec\u7279\u7597\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u6211\u4eec\u5dee\u5f02\u5316\u4ea7\u54c1\u7ec4\u5408\u7684\u591a\u9879\u8054\u5408\u7814\u7a76\uff0c\u5305\u62ec BRII-179\uff08\u4e00\u79cd\u91cd\u7ec4\u86cb\u767dHBV\u514d\u75ab\u6cbb\u7597\u5019\u9009\u836f\u7269\uff0c\u7531\u817e\u76db\u535a\u836f\u5f00\u5c55 elebsiran \u548c BRII-179 \u8054\u5408\u7597\u6cd5\u7684\u7814\u7a76\uff09 \u3001elebsiran\uff08\u7531\u817e\u76db\u535a\u836f\u5f00\u5c55 elebsiran \u548c PEG-IFN\u03b1 \u8054\u5408\u7814\u7a76\uff09\u4ee5\u53catobevibart\uff08\u4e00\u79cd\u9776\u5411HBV\u7684\u7814\u7a76\u6027\u5e7f\u6cdb\u4e2d\u548c\u5355\u514b\u9686\u6297\u4f53\uff0cVir Biotechnology\u6b63\u5c31tobevibart\u548celebsiran\u8054\u5408\u7597\u6cd5\u5f00\u5c55\u591a\u9879 2 \u671f\u548c 3 \u671f\u7814\u7a76 \uff09\u3002\u57282025\u5e74\u63a5\u4e0b\u6765\u7684\u51e0\u4e2a\u6708\uff0c\u6211\u4eec\u5c06\u5728\u5404\u5927\u79d1\u5b66\u4f1a\u8bae\u4e0a\u6301\u7eed\u5206\u4eab\u5173\u952e\u6570\u636e\u3002<\/p>\n<p>\u5173\u4e8e\u4e59\u578b\u809d\u708e <\/p>\n<p>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u80c1\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.54\u4ebf\u3002[1]\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7ea6\u670982\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027HBV\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u3002[1]\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u4eba\u6570\u8fbe8,700\u4e07\uff0c\u975e\u5e38\u503c\u5f97\u5173\u6ce8\u3002[2]<\/p>\n<p>\u5173\u4e8eBRII-179<\/p>\n<p>BRII-179\u662f\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u8d28\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7597\u5019\u9009\u836f\u7269\uff0c\u53ef\u8868\u8fbeHBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8bf1\u5bfc\u589e\u5f3a\u548c\u5e7f\u6cdb\u7684B\u7ec6\u80de\u548cT\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u6cbb\u7597\u8ba4\u5b9a\u3002<\/p>\n<p>\u5173\u4e8eElebsiran\uff08BRII-835\uff0cVIR-2218\uff09 <\/p>\n<p>Elebsiran\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u836f\u7269\uff0c\u65e8\u5728\u964d\u89e3\u4e59\u578b\u809d\u708e\u75c5\u6bd2RNA\u8f6c\u5f55\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u4ea7\u751f\uff0c\u5176\u5177\u6709\u9488\u5bf9HBV\u53caHDV\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u91c7\u7528\u589e\u5f3a\u7a33\u5b9a\u5316\u5b66\u589e\u5f3a\u6280\u672f\u7684siRNA\uff0c\u4ee5\u589e\u5f3a\u7a33\u5b9a\u6027\u5e76\u6700\u5927\u7a0b\u5ea6\u5730\u51cf\u5c11\u8131\u9776\u6d3b\u6027\uff0c\u4ece\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7597\u6307\u6570\u3002\u817e\u76db\u535a\u836f\u4e8e2020\u5e74\u4eceVir Biotechnology, Inc.\u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316elebsiran\u7684\u72ec\u5bb6\u6743\u76ca\u3002<\/p>\n<p>\u5173\u4e8e\u817e\u76db\u535a\u836f<\/p>\n<p>\u817e\u76db\u535a\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6ee1\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7ed9\u60a3\u8005\u5e26\u6765\u4e25\u91cd\u793e\u4f1a\u6b67\u89c6\u7684\u91cd\u5927\u516c\u5171\u536b\u751f\u6311\u6218\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u3002\u516c\u53f8\u4e13\u6ce8\u4e8e\u611f\u67d3\u6027\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u8fdb\u4e00\u6761\u6db5\u76d6\u591a\u79cd\u72ec\u7279\u5019\u9009\u836f\u7269\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u91cd\u70b9\u5305\u62ec\u9488\u5bf9\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9886\u5148\u9879\u76ee\u3002\u5728\u5bcc\u6709\u8fdc\u89c1\u5353\u8bc6\u548c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u9886\u5bfc\u56e2\u961f\u5e26\u9886\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u4e8e\u7f57\u5229-\u8fbe\u52d2\u59c6\u3001\u65e7\u91d1\u5c71\u6e7e\u533a\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u672f\u4e2d\u5fc3\u5f00\u5c55\u4e1a\u52a1\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"https:\/\/www.briibio.com\/\" target=\"_blank\" rel=\"noopener\">www.briibio.com<\/a> \u3002<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] World Health Organization. Hepatitis. World Health Organization. Retrieved from <a class=\"prnews_a\" href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C\" target=\"_blank\" rel=\"noopener\">https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>SOURCE  \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>","protected":false},"excerpt":{"rendered":"<p>ENSURE\u7814\u7a76\u961f\u52174\u7684\u521d\u6b65\u6570\u636e\u652f\u6301\u4e00\u9879\u65b0\u9896\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u5229\u7528BRII-179\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u60a3\u8005\uff0c\u4f7f\u5176\u6709\u671b\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff08EOT\uff09\u5b9e\u73b0\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387ENSURE\u7814\u7a76\u961f\u52171-3\u768448\u5468EOT\u6570\u636e\u6e05\u695a\u8868\u660e\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u53ef\u5b9e\u73b0\u989d\u5916\u83b7\u76ca\uff0c\u8fbe\u5230\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387 \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62025\u5e743\u670830\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08&#8221;\u817e\u76db\u535a\u836f&#8221;\u6216&#8221;\u516c\u53f8&#8221;\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u5728\u4e2d\u56fd\u5317\u4eac\u4e3e\u884c\u7684\u7b2c34\u5c4a\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\u5e74\u4f1a\uff08APASL 2025\uff09\u4e0a\uff0c\u516c\u53f8\u4ee5\u6700\u65b0\u7a81\u7834\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\u3002 ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u60272\u671f\u7814\u7a76\u3002\u961f\u52171-3\u65e8\u5728\u8bc4\u4f30elebsiran\uff08\u4e00\u79cd\u7814\u7a76\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\uff09\u5728\u4e0e\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u8054\u5408\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\uff08\u57fa\u7ebf\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u4e3a100-3,000 IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002\u5728\u5148\u524d\u7684\u4e9a\u592a\u5730\u533a\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u8fc79\u5242BRII-179\uff08\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u8054\u5408elebsiran\uff08BRII-835\uff09\u7ed9\u836f\u7684\u53c2\u4e0e\u8005\u88ab\u7eb3\u5165\u8be5\u7814\u7a76\u7684\u961f\u52174\uff0c\u5e76\u63a5\u53d7elebsiran\u548cPEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u3002\u672c\u7814\u7a76\u961f\u52174\u7684\u8bbe\u8ba1\u57fa\u4e8e\u65e2\u5f80\u7814\u7a76\u7684\u89c1\u89e3\uff0c\u5373\u5f88\u5927\u4e00\u90e8\u5206\u6162\u6027HBV\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u6027\u75ab\u82d7\u7684\u591a\u6b21\u6cbb\u7597\u540e\u672a\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u56e0\u6b64\u4e0d\u592a\u53ef\u80fd\u83b7\u5f97\u514d\u75ab\u652f\u6301\u4ee5\u5b9e\u73b0\u6301\u4e45\u7684\u529f\u80fd\u6027\u6cbb\u6108\u3002 \u961f\u52174\u7684\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c\u8fc7\u5f80\u4ea7\u751fBRII-179\u8bf1\u5bfc\u7684\u4e59\u809d\u8868\u9762\u6297\u4f53\uff08\u6297-HBs\uff09\u5e94\u7b54\u7684\u53c2\u4e0e\u8005\uff0c\u5176HBsAg\u8840\u6e05\u6e05\u9664\u7387\u663e\u8457\u9ad8\u4e8e\u672a\u4ea7\u751f\u5e94\u7b54\u7684\u53c2\u4e0e\u8005\u3002\u7b2c24\u5468\u65f6\uff0c\u8d85\u8fc7\u534a\u6570\u7684BRII-179\u5e94\u7b54\u8005\uff0855.6% [10\/18]\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u53ea\u670910.0%\uff081\/10\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u672c\u6b21\u516c\u5e03\u7684\u6570\u636e\u8868\u660e\uff0cBRII-179\u6709\u6f5c\u529b\u6210\u4e3a\u4e00\u79cd\u9884\u6d4b\u5de5\u5177\uff0c\u7528\u4e8e\u7b5b\u9009\u51fa\u66f4\u53ef\u80fd\u5bf9\u6cbb\u6108\u65b9\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u3002 \u6b64\u6b21\u516c\u5e03\u7684ENSURE\u7814\u7a76\u4e2d\u961f\u52171-3\u989d\u5916\u6570\u636e\u663e\u793a\uff0c\u4e0e\u63a5\u53d7PEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u5728\u6cbb\u7597\u7ed3\u675f (EOT) \u65f6\u6709\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387\u548c\u8840\u6e05\u8f6c\u6362\u7387\u3002 \u9ec4\u4e3d\u8679\u6559\u6388\uff08\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff09\u8868\u793a\uff1a&#8221;ENSURE\u7814\u7a76\u961f\u52174\u7684\u79ef\u6781\u6570\u636e\u4e3aHBV\u529f\u80fd\u6027\u6cbb\u6108\u6253\u5f00\u4e86\u65b0\u7684\u5927\u95e8\u3002\u65e2\u5f80\u7814\u7a76\u8868\u660e\uff0cBRII-179\u53ef\u80fd\u4e3a\u8bc6\u522b\u80fd\u591f\u4ea7\u751f\u5fc5\u8981\u7684HBsAg\u6297\u4f53\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e \uff08CHB\uff09\u60a3\u8005\u63d0\u4f9b\u65b0\u8def\u5f84\u3002\u6211\u76f8\u4fe1\uff0c\u8fd9\u6b21\u7684\u65b0\u6570\u636e\u4e3aBRII-179\u5728\u7b5b\u9009\u6cbb\u7597\u83b7\u76ca\u4eba\u7fa4\u65b9\u9762\u7684\u4ef7\u503c\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u8bc1\u636e\uff0c\u8fdb\u4e00\u6b65\u786e\u7acb\u4e86BRII-179\u5728\u672a\u6765\u8054\u5408\u7597\u6cd5\u683c\u5c40\u4e2d\u7684\u5730\u4f4d\u3002&#8221; \u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a&#8221;ENSURE\u7814\u7a76\u961f\u52174\u7684\u6570\u636e\u7ee7\u7eed\u652f\u6301\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u7814\u7a76\u7ed3\u679c\u8fdb\u4e00\u6b65\u51f8\u663e\u4e86BRII-179\u5728\u8bc6\u522b\u66f4\u53ef\u80fd\u5bf9\u529f\u80fd\u6027\u6cbb\u6108\u7597\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u901a\u8fc7\u60a3\u8005\u5bcc\u96c6\u7b56\u7565\u80fd\u63d0\u9ad8\u76ee\u6807\u4eba\u7fa4\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u6709\u52a9\u4e8e\u964d\u4f4e\u6cbb\u6108\u6982\u7387\u8f83\u4f4e\u4eba\u7fa4\u7684\u6cbb\u7597\u6210\u672c\u8d1f\u62c5\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u901a\u8fc7\u6b63\u5728\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u4e0e\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u7684\u5408\u4f5c\uff0c\u5c06BRII-179\u4e0e\u591a\u79cd\u7597\u6cd5\u7ed3\u5408\u4f7f\u7528\uff0c\u4ee5\u671f\u4e3a\u5168\u74032.54\u4ebf\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u5b9e\u73b0\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002&#8221; \u6458\u8981\u7f16\u53f7\uff1aOP0335 \u62a5\u544a\u6807\u9898\uff1a\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u4ea7\u751f\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u8005\u5728\u63a5\u53d7elebsiran \u548c PEG-IFN\u03b1 \u6cbb\u7597\u540e\u53ef\u83b7\u5f97\u66f4\u5feb\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\uff1a\u6765\u81eaENSURE\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u00a0 \u4e3b\u8bb2\u4eba\uff1a\u9ec4\u4e3d\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a \u5728\u961f\u52174\u4e2d\u5165\u7ec4\u768431\u4f8b\u53c2\u4e0e\u8005\u4e2d\uff0c\u670928\u4f8b\u57fa\u7ebfHBsAg \u2265 100 IU\/mL\u7684\u53c2\u4e0e\u8005\u88ab\u7eb3\u5165\u5206\u6790\u3002\u5176\u4e2d\uff0c18\u4f8b\u901a\u8fc7\u5148\u524dBRII-179\u6cbb\u7597\u8bf1\u5bfc\u7684\u6297-HBs\u5cf0\u503c\u226510 IU\/L\u7684\u53d7\u8bd5\u8005\u88ab\u5b9a\u4e49\u4e3aBRII-179\u5e94\u7b54\u8005\uff0c10\u4f8b\u6297-HBs\u5cf0\u503c&lt;10 IU\/L\u7684\u53d7\u8bd5\u8005\u88ab\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\u3002\u5728elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u7b2c24\u5468\u65f6\uff0c\u961f\u52174\u53c2\u4e0e\u8005\u4e2d\u670939.3%\uff0811\/28\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u7b2c24\u5468\u65f6\uff0cBRII-179\u5e94\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u4e3a55.6%\uff0810\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\u768410%\uff081\/10\uff09\u3002\u4e0e\u6b64\u524d\u62a5\u544a\u7684\u63a5\u53d7elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u4f46\u672a\u7ecfBRII-179\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u65e2\u5f80\u63a5\u53d7BRII-179\u6cbb\u7597\u7684\u5e94\u7b54\u8005\u4f3c\u4e4e\u53ef\u4ee5\u5b9e\u73b0\u66f4\u5feb\u7684HBsAg\u8840\u6e05\u6e05\u9664\u3002\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002Elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u4f1a\u6301\u7eed48\u5468\u3002 \u6458\u8981\u7f16\u53f7\uff1aLB0009 \u62a5\u544a\u6807\u9898\uff1a\u4e0e\u5355\u7528\u00a0PEG-IFN\u03b1 \u76f8\u6bd4\uff0c\u63a5\u53d7 elebsiran \u548cPEG-IFN\u03b1\u6cbb\u7597\u7684\u6162\u6027 HBV \u611f\u67d3\u8005\u5728\u6cbb\u7597\u7ed3\u675f (EOT) \u65f6 HBsAg \u6e05\u9664\u7387\u548c\u8840\u6e05\u8f6c\u6362\u7387\u66f4\u9ad8\uff1a \u6b63\u5728\u8fdb\u884c\u7684ENSURE\u7814\u7a76\u7b2c48\u5468\u7ed3\u679c \u4e3b\u8bb2\u4eba\uff1a\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0cM.D.\uff0cPh.D.\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u4e2d\u56fd\u5317\u4eac EOT\u65f6\uff0c\u5728\u57fa\u7ebfHBsAg\u6c34\u5e73\u4e3a100-3,000 IU\/mL\u7684\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran 200 mg + [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":9219,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"class_list":["post-9218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u817e\u76db\u535a\u836f\u57282025\u5e74\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\u5e74\u4f1a\uff08APASL\uff09\u4e0a\u516c\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u65b0\u6570\u636e\uff0c\u8868\u660eBRII-179\u6709\u671b\u901a\u8fc7\u76ee\u6807\u60a3\u8005\u8bc6\u522b\u63d0\u9ad8HBsAg\u6e05\u9664\u7387 - Money Compass CN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/moneycompass.com.my\/cn\/\u817e\u76db\u535a\u836f\u57282025\u5e74\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\u5e74\u4f1a\uff08apasl\uff09\u4e0a\u516c\u5e03\u5176\u6b63\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u817e\u76db\u535a\u836f\u57282025\u5e74\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\u5e74\u4f1a\uff08APASL\uff09\u4e0a\u516c\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u65b0\u6570\u636e\uff0c\u8868\u660eBRII-179\u6709\u671b\u901a\u8fc7\u76ee\u6807\u60a3\u8005\u8bc6\u522b\u63d0\u9ad8HBsAg\u6e05\u9664\u7387 - Money Compass CN\" \/>\n<meta property=\"og:description\" content=\"ENSURE\u7814\u7a76\u961f\u52174\u7684\u521d\u6b65\u6570\u636e\u652f\u6301\u4e00\u9879\u65b0\u9896\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u5229\u7528BRII-179\u8bc6\u522b\u514d\u75ab\u5e94\u7b54\u60a3\u8005\uff0c\u4f7f\u5176\u6709\u671b\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff08EOT\uff09\u5b9e\u73b0\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387ENSURE\u7814\u7a76\u961f\u52171-3\u768448\u5468EOT\u6570\u636e\u6e05\u695a\u8868\u660e\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u53ef\u5b9e\u73b0\u989d\u5916\u83b7\u76ca\uff0c\u8fbe\u5230\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387 \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62025\u5e743\u670830\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08&#8221;\u817e\u76db\u535a\u836f&#8221;\u6216&#8221;\u516c\u53f8&#8221;\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u7684\u75be\u75c5\u5f00\u53d1\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\u6cbb\u7597\u9009\u62e9\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u5728\u4e2d\u56fd\u5317\u4eac\u4e3e\u884c\u7684\u7b2c34\u5c4a\u4e9a\u592a\u809d\u75c5\u5b66\u4f1a\u5e74\u4f1a\uff08APASL 2025\uff09\u4e0a\uff0c\u516c\u53f8\u4ee5\u6700\u65b0\u7a81\u7834\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u5176\u6b63\u5728\u8fdb\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\u3002 ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u60272\u671f\u7814\u7a76\u3002\u961f\u52171-3\u65e8\u5728\u8bc4\u4f30elebsiran\uff08\u4e00\u79cd\u7814\u7a76\u6027\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\uff09\u5728\u4e0e\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u8054\u5408\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\uff08\u57fa\u7ebf\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u4e3a100-3,000 IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002\u5728\u5148\u524d\u7684\u4e9a\u592a\u5730\u533a\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u8fc79\u5242BRII-179\uff08\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u8054\u5408elebsiran\uff08BRII-835\uff09\u7ed9\u836f\u7684\u53c2\u4e0e\u8005\u88ab\u7eb3\u5165\u8be5\u7814\u7a76\u7684\u961f\u52174\uff0c\u5e76\u63a5\u53d7elebsiran\u548cPEG-IFN\u03b1\u8054\u5408\u6cbb\u7597\u3002\u672c\u7814\u7a76\u961f\u52174\u7684\u8bbe\u8ba1\u57fa\u4e8e\u65e2\u5f80\u7814\u7a76\u7684\u89c1\u89e3\uff0c\u5373\u5f88\u5927\u4e00\u90e8\u5206\u6162\u6027HBV\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u6027\u75ab\u82d7\u7684\u591a\u6b21\u6cbb\u7597\u540e\u672a\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u56e0\u6b64\u4e0d\u592a\u53ef\u80fd\u83b7\u5f97\u514d\u75ab\u652f\u6301\u4ee5\u5b9e\u73b0\u6301\u4e45\u7684\u529f\u80fd\u6027\u6cbb\u6108\u3002 \u961f\u52174\u7684\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c\u8fc7\u5f80\u4ea7\u751fBRII-179\u8bf1\u5bfc\u7684\u4e59\u809d\u8868\u9762\u6297\u4f53\uff08\u6297-HBs\uff09\u5e94\u7b54\u7684\u53c2\u4e0e\u8005\uff0c\u5176HBsAg\u8840\u6e05\u6e05\u9664\u7387\u663e\u8457\u9ad8\u4e8e\u672a\u4ea7\u751f\u5e94\u7b54\u7684\u53c2\u4e0e\u8005\u3002\u7b2c24\u5468\u65f6\uff0c\u8d85\u8fc7\u534a\u6570\u7684BRII-179\u5e94\u7b54\u8005\uff0855.6% [10\/18]\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u65e0\u5e94\u7b54\u8005\u53ea\u670910.0%\uff081\/10\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u672c\u6b21\u516c\u5e03\u7684\u6570\u636e\u8868\u660e\uff0cBRII-179\u6709\u6f5c\u529b\u6210\u4e3a\u4e00\u79cd\u9884\u6d4b\u5de5\u5177\uff0c\u7528\u4e8e\u7b5b\u9009\u51fa\u66f4\u53ef\u80fd\u5bf9\u6cbb\u6108\u65b9\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u3002 \u6b64\u6b21\u516c\u5e03\u7684ENSURE\u7814\u7a76\u4e2d\u961f\u52171-3\u989d\u5916\u6570\u636e\u663e\u793a\uff0c\u4e0e\u63a5\u53d7PEG-IFN\u03b1\u5355\u836f\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7elebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u5728\u6cbb\u7597\u7ed3\u675f (EOT) \u65f6\u6709\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387\u548c\u8840\u6e05\u8f6c\u6362\u7387\u3002 \u9ec4\u4e3d\u8679\u6559\u6388\uff08\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff09\u8868\u793a\uff1a&#8221;ENSURE\u7814\u7a76\u961f\u52174\u7684\u79ef\u6781\u6570\u636e\u4e3aHBV\u529f\u80fd\u6027\u6cbb\u6108\u6253\u5f00\u4e86\u65b0\u7684\u5927\u95e8\u3002\u65e2\u5f80\u7814\u7a76\u8868\u660e\uff0cBRII-179\u53ef\u80fd\u4e3a\u8bc6\u522b\u80fd\u591f\u4ea7\u751f\u5fc5\u8981\u7684HBsAg\u6297\u4f53\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e \uff08CHB\uff09\u60a3\u8005\u63d0\u4f9b\u65b0\u8def\u5f84\u3002\u6211\u76f8\u4fe1\uff0c\u8fd9\u6b21\u7684\u65b0\u6570\u636e\u4e3aBRII-179\u5728\u7b5b\u9009\u6cbb\u7597\u83b7\u76ca\u4eba\u7fa4\u65b9\u9762\u7684\u4ef7\u503c\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u8bc1\u636e\uff0c\u8fdb\u4e00\u6b65\u786e\u7acb\u4e86BRII-179\u5728\u672a\u6765\u8054\u5408\u7597\u6cd5\u683c\u5c40\u4e2d\u7684\u5730\u4f4d\u3002&#8221; \u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a&#8221;ENSURE\u7814\u7a76\u961f\u52174\u7684\u6570\u636e\u7ee7\u7eed\u652f\u6301\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u7814\u7a76\u7ed3\u679c\u8fdb\u4e00\u6b65\u51f8\u663e\u4e86BRII-179\u5728\u8bc6\u522b\u66f4\u53ef\u80fd\u5bf9\u529f\u80fd\u6027\u6cbb\u6108\u7597\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u901a\u8fc7\u60a3\u8005\u5bcc\u96c6\u7b56\u7565\u80fd\u63d0\u9ad8\u76ee\u6807\u4eba\u7fa4\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u6709\u52a9\u4e8e\u964d\u4f4e\u6cbb\u6108\u6982\u7387\u8f83\u4f4e\u4eba\u7fa4\u7684\u6cbb\u7597\u6210\u672c\u8d1f\u62c5\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u901a\u8fc7\u6b63\u5728\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u4e0e\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u7684\u5408\u4f5c\uff0c\u5c06BRII-179\u4e0e\u591a\u79cd\u7597\u6cd5\u7ed3\u5408\u4f7f\u7528\uff0c\u4ee5\u671f\u4e3a\u5168\u74032.54\u4ebf\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u5b9e\u73b0\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002&#8221; \u6458\u8981\u7f16\u53f7\uff1aOP0335 \u62a5\u544a\u6807\u9898\uff1a\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u4ea7\u751f\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u8005\u5728\u63a5\u53d7elebsiran \u548c PEG-IFN\u03b1 \u6cbb\u7597\u540e\u53ef\u83b7\u5f97\u66f4\u5feb\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\uff1a\u6765\u81eaENSURE\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u00a0 \u4e3b\u8bb2\u4eba\uff1a\u9ec4\u4e3d\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a 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Margolis\u535a\u58eb\u8868\u793a\uff1a&#8221;ENSURE\u7814\u7a76\u961f\u52174\u7684\u6570\u636e\u7ee7\u7eed\u652f\u6301\u6211\u4eec\u5728\u76ee\u6807\u4eba\u7fa4\u4e2d\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u8fd9\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\u3002\u7814\u7a76\u7ed3\u679c\u8fdb\u4e00\u6b65\u51f8\u663e\u4e86BRII-179\u5728\u8bc6\u522b\u66f4\u53ef\u80fd\u5bf9\u529f\u80fd\u6027\u6cbb\u6108\u7597\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u65b9\u9762\u7684\u6f5c\u529b\uff0c\u901a\u8fc7\u60a3\u8005\u5bcc\u96c6\u7b56\u7565\u80fd\u63d0\u9ad8\u76ee\u6807\u4eba\u7fa4\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u6709\u52a9\u4e8e\u964d\u4f4e\u6cbb\u6108\u6982\u7387\u8f83\u4f4e\u4eba\u7fa4\u7684\u6cbb\u7597\u6210\u672c\u8d1f\u62c5\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u901a\u8fc7\u6b63\u5728\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u4e0e\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u7684\u5408\u4f5c\uff0c\u5c06BRII-179\u4e0e\u591a\u79cd\u7597\u6cd5\u7ed3\u5408\u4f7f\u7528\uff0c\u4ee5\u671f\u4e3a\u5168\u74032.54\u4ebf\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u5b9e\u73b0\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002&#8221; \u6458\u8981\u7f16\u53f7\uff1aOP0335 \u62a5\u544a\u6807\u9898\uff1a\u5bf9\u65e2\u5f80BRII-179\u6cbb\u7597\u4ea7\u751f\u5e94\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u8005\u5728\u63a5\u53d7elebsiran \u548c PEG-IFN\u03b1 \u6cbb\u7597\u540e\u53ef\u83b7\u5f97\u66f4\u5feb\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\uff1a\u6765\u81eaENSURE\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u00a0 \u4e3b\u8bb2\u4eba\uff1a\u9ec4\u4e3d\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u6570\u636e\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u80a0\u80c3\u53ca\u809d\u75c5\u79d1\u4e13\u79d1\u6559\u6388\uff0c\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a \u5728\u961f\u52174\u4e2d\u5165\u7ec4\u768431\u4f8b\u53c2\u4e0e\u8005\u4e2d\uff0c\u670928\u4f8b\u57fa\u7ebfHBsAg \u2265 100 IU\/mL\u7684\u53c2\u4e0e\u8005\u88ab\u7eb3\u5165\u5206\u6790\u3002\u5176\u4e2d\uff0c18\u4f8b\u901a\u8fc7\u5148\u524dBRII-179\u6cbb\u7597\u8bf1\u5bfc\u7684\u6297-HBs\u5cf0\u503c\u226510 IU\/L\u7684\u53d7\u8bd5\u8005\u88ab\u5b9a\u4e49\u4e3aBRII-179\u5e94\u7b54\u8005\uff0c10\u4f8b\u6297-HBs\u5cf0\u503c&lt;10 IU\/L\u7684\u53d7\u8bd5\u8005\u88ab\u5b9a\u4e49\u4e3a\u65e0\u5e94\u7b54\u8005\u3002\u5728elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u7b2c24\u5468\u65f6\uff0c\u961f\u52174\u53c2\u4e0e\u8005\u4e2d\u670939.3%\uff0811\/28\uff09\u5b9e\u73b0\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u7b2c24\u5468\u65f6\uff0cBRII-179\u5e94\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u4e3a55.6%\uff0810\/18\uff09\uff0c\u660e\u663e\u9ad8\u4e8e\u65e0\u5e94\u7b54\u8005\u768410%\uff081\/10\uff09\u3002\u4e0e\u6b64\u524d\u62a5\u544a\u7684\u63a5\u53d7elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u4f46\u672a\u7ecfBRII-179\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u65e2\u5f80\u63a5\u53d7BRII-179\u6cbb\u7597\u7684\u5e94\u7b54\u8005\u4f3c\u4e4e\u53ef\u4ee5\u5b9e\u73b0\u66f4\u5feb\u7684HBsAg\u8840\u6e05\u6e05\u9664\u3002\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c2\u4e0e\u8005\u4e2d\uff0celebsiran\u8054\u5408PEG-IFN\u03b1\u6cbb\u7597\u603b\u4f53\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002Elebsiran + PEG-IFN\u03b1\u6cbb\u7597\u4f1a\u6301\u7eed48\u5468\u3002 \u6458\u8981\u7f16\u53f7\uff1aLB0009 \u62a5\u544a\u6807\u9898\uff1a\u4e0e\u5355\u7528\u00a0PEG-IFN\u03b1 \u76f8\u6bd4\uff0c\u63a5\u53d7 elebsiran \u548cPEG-IFN\u03b1\u6cbb\u7597\u7684\u6162\u6027 HBV \u611f\u67d3\u8005\u5728\u6cbb\u7597\u7ed3\u675f (EOT) \u65f6 HBsAg \u6e05\u9664\u7387\u548c\u8840\u6e05\u8f6c\u6362\u7387\u66f4\u9ad8\uff1a \u6b63\u5728\u8fdb\u884c\u7684ENSURE\u7814\u7a76\u7b2c48\u5468\u7ed3\u679c 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