{"id":9273,"date":"2025-03-31T10:13:00","date_gmt":"2025-03-31T10:13:00","guid":{"rendered":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832024%e5%b9%b4%e5%ba%a6%e4%b8%9a%e7%bb%a9\/"},"modified":"2025-03-31T10:13:00","modified_gmt":"2025-03-31T10:13:00","slug":"%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832024%e5%b9%b4%e5%ba%a6%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/moneycompass.com.my\/cn\/%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832024%e5%b9%b4%e5%ba%a6%e4%b8%9a%e7%bb%a9\/","title":{"rendered":"\u548c\u94c2\u533b\u836f\u516c\u5e032024\u5e74\u5ea6\u4e1a\u7ee9"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u4e2d\u56fd\u4e0a\u6d77\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e39<\/span><span class=\"legendSpanClass\">2025\u5e743\u670831\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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2025 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Mice\u00ae\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297\u4f53\u3002\u76f8\u8f83\u4e8e\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u5177\u6709\u663e\u8457\u589e\u52a0\u7684Treg\u7ec6\u80de\u6e05\u9664\u548c\u4f18\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u72ec\u7279\u53ca\u826f\u597d\u7684\u7279\u6027\uff0c\u6709\u52a9\u4e8e\u63d0\u9ad8\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u589e\u5f3a\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u63d0\u5347\u4e86\u9009\u62e9\u6027\u6e05\u9664\u7624\u5185Treg\u7ec6\u80de\u7684\u6f5c\u529b\uff0c\u6709\u671b\u514b\u670d\u73b0\u6709CTLA-4\u7597\u6cd5\u7684\u7597\u6548\u548c\u6bd2\u6027\u74f6\u9888\u3002\u516c\u53f8\u5df2\u5f00\u5c55\u666e\u9c81\u82cf\u62dc\u5355\u6297\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u5168\u7403\u5f00\u53d1\u8ba1\u5212\uff0c\u5e76\u91c7\u7528\u4e86\u666e\u9c81\u82cf\u62dc\u5355\u6297\u7684\u9002\u5e94\u6027\u6cbb\u7597\u8bbe\u8ba1\u3002\u5728\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u7684\u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u8054\u5408PD-1\u6291\u5236\u5242\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u764c\u53ca\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u79ef\u6781\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u6570\u636e\u3002<\/p>\n<p>HBM1020\u662f\u4e00\u6b3e\u57fa\u4e8eH2L2 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Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684\u9776\u5411B7H7\u7684\u5168\u7403\u9996\u521b\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002B7H7\u662f\u4e00\u79cd\u65b0\u578b\u514d\u75ab\u8c03\u8282\u5206\u5b50\uff0c\u5c5e\u4e8eB7\u5bb6\u65cf\uff0c\u80fd\u72ec\u7acb\u4e8ePD-L1\u8868\u8fbe\u4ece\u800c\u5728\u80bf\u7624\u514d\u75ab\u9003\u9038\u65b9\u9762\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u51ed\u501f\u5176\u51fa\u8272\u7684\u4ea7\u54c1\u8bbe\u8ba1\u548c\u9776\u70b9\u7279\u5f81\uff0cHBM1020\u6709\u671b\u89e3\u51b3\u5b9e\u4f53\u7624\u6cbb\u7597\u9886\u57df\u5c1a\u672a\u6ee1\u8db3\u7684\u5de8\u5927\u533b\u7597\u9700\u6c42\u30022024\u5e749\u6708\uff0c\u516c\u53f8\u4e8eESMO\u5e74\u4f1a\u4e0a\u516c\u5e03HBM1020\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u6700\u65b0\u4e34\u5e8a\u6570\u636e\uff0c\u6570\u636e\u663e\u793aHBM1020\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5728\u63a5\u53d7\u6cbb\u7597\u540e\u80bf\u7624\u8bc4\u4f30\u768415\u4f8b\u60a3\u8005\u4e2d\uff0c7\u4f8b\u60a3\u8005\uff0846.7%\uff09\u8fbe\u5230\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\uff0c\u5176\u4e2d2\u4f8b\u60a3\u8005\u89c2\u5bdf\u5230\u80bf\u7624\u7f29\u5c0f\uff0c\u7f29\u5c0f\u6bd4\u4f8b\u5206\u522b\u4e3a11%\u548c25%\u3002<\/p>\n<p>IND\u53caIND\u51c6\u5907\u9636\u6bb5\u7684\u4e3b\u8981\u5019\u9009\u4ea7\u54c1\u5305\u62ec\uff1a<\/p>\n<p>HBM7020\u662f\u4e00\u6b3e\u5229\u7528\u5168\u4eba\u6e90HBICE\u00ae\u53cc\u6297\u6280\u672f\u53caHarbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u7684BCMAxCD3\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002HBM7020\u80fd\u591f\u901a\u8fc7\u9776\u5411\u7ec6\u80de\u8868\u9762\u7684BCMA\u548cCD3\uff0c\u5c06\u76ee\u6807\u7ec6\u80de\u4e0eT\u7ec6\u80de\u4ea4\u8054\uff0c\u4ece\u800c\u6709\u6548\u6fc0\u6d3bT\u7ec6\u80de\u5e76\u6740\u4f24\u76ee\u6807\u7ec6\u80de\u3002HBM7020\u901a\u8fc7\u8bbe\u8ba1\u4e24\u4e2a\u6297BCMA\u7ed3\u5408\u4f4d\u70b9\uff0c\u5b9e\u73b0\u4e86\u5bf9\u76ee\u6807\u7ec6\u80de\u7684\u7cbe\u51c6\u9776\u5411\uff0c\u800c\u5355\u4ef7\u4f18\u5316\u7684CD3\u6d3b\u6027\u5219\u6709\u6548\u964d\u4f4e\u4e86\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u7684\u53d1\u751f\u98ce\u9669\u3002\u57fa\u4e8e\u8fd9\u4e9b\u521b\u65b0\u673a\u5236\uff0cHBM7020\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u7ec6\u80de\u6740\u4f24\u6548\u5e94\uff0c\u5728\u514d\u75ab\u5b66\u548c\u80bf\u7624\u9886\u57df\u5747\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u30022023\u5e748\u6708\uff0cHBM7020\u83b7\u6279\u5728\u4e2d\u56fd\u542f\u52a8\u9488\u5bf9\u764c\u75c7\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 2024\u5e74\uff0c\u516c\u53f8\u8c03\u6574\u4e86\u5f00\u53d1\u7b56\u7565\uff0c\u5c06\u9002\u5e94\u75c7\u8f6c\u5411\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\uff0c\u76ee\u524d\u6b63\u5728\u51c6\u5907\u9012\u4ea4IND\u7533\u8bf7\u3002<\/p>\n<p>HBM9027\u662f\u4e00\u6b3e\u65b0\u578bPD-L1xCD40\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u91c7\u7528HBICE\u00ae\u53cc\u7279\u5f02\u6027\u6297\u4f53\u6280\u672f\u53caHarbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\u3002\u8be5\u6b3ePD-L1xCD40\u53cc\u6297\u7684\u5f00\u53d1\u5c06\u516c\u53f8\u7684\u53cc\u7279\u5f02\u6027\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u6811\u7a81\u72b6\u7ec6\u80de\/\u9ad3\u7cfb\u7ec6\u80de\u8854\u63a5\u5668\u8fd9\u4e00\u524d\u6cbf\u9886\u57df\uff0c\u5145\u5206\u5c55\u73b0\u51faHBICE\u00ae\u5728\u51e0\u4f55\u7ed3\u6784\u4e0a\u7684\u7075\u6d3b\u9002\u7528\u6027\u53ca\u5373\u63d2\u5373\u7528\u4f18\u52bf\u30022024\u5e741\u6708\uff0cHBM9027\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684IND\u6279\u51c6\uff0c\u5728\u7f8e\u56fd\u542f\u52a8I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>HBM7004\u662f\u4e00\u6b3e\u65b0\u578bB7H4xCD3\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7531HBICE\u00ae\u548cHarbour Mice\u00ae\u5e73\u53f0\u5f00\u53d1\uff0c\u4ece\u7597\u6548\u548c\u5b89\u5168\u6027\u4e24\u4e2a\u7ef4\u5ea6\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u521b\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002\u8be5\u4ea7\u54c1\u7684\u5f00\u53d1\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u516c\u53f8\u7684\u53cc\u7279\u5f02\u6027\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\u5e73\u53f0\uff0c\u5f70\u663e\u4e86HBICE\u00ae\u7684\u7075\u6d3b\u9002\u7528\u6027\u548c\u5373\u63d2\u5373\u7528\u4f18\u52bf\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cHBM7004\u5448\u73b0\u51fa\u80bf\u7624\u5185B7H4\u4f9d\u8d56\u6027T\u7ec6\u80de\u6fc0\u6d3b\u673a\u5236\u3002\u5728\u591a\u79cd\u52a8\u7269\u6a21\u578b\u5b9e\u9a8c\u4e2d\uff0cHBM7004\u8868\u73b0\u51fa\u5f3a\u52b2\u7684\u6297\u80bf\u7624\u6548\u679c\u3001\u51fa\u8272\u7684\u4f53\u5185\u7a33\u5b9a\u6027\u4ee5\u53ca\u8f83\u4f4e\u7684\u5168\u8eab\u6bd2\u6027\u3002\u6b64\u5916\uff0c\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0cHBM7004\u4e0eB7H4x4-1BB\u53cc\u6297\u5728\u4f4e\u6548\u5e94\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u6bd4\u7387\u6761\u4ef6\u4e0b\u8054\u7528\u5177\u6709\u5f88\u5f3a\u7684\u534f\u540c\u4f5c\u7528\uff0c\u663e\u793a\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u6cbb\u7597\u7a97\u53e3\u3002\u76ee\u524d\uff0c\u516c\u53f8\u6b63\u5728\u8fdb\u884cHBM7004\u7684IND\u7b79\u5907\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u3002<\/p>\n<p>HBM9014\u662f\u4e00\u6b3e\u540c\u7c7b\u9996\u521b\u3001\u9776\u5411\u767d\u8840\u75c5\u6291\u5236\u56e0\u5b50\u53d7\u4f53\uff08LIFR\uff09\u7684\u6297\u80bf\u7624\u7597\u6cd5\u3002\u8be5\u6b3e\u5168\u4eba\u6e90\u6297\u4f53\u7597\u6cd5\u7531Harbour Mice\u00ae\u5e73\u53f0\u7814\u53d1\uff0c\u901a\u8fc7LIFR\u963b\u65ad\u591a\u4e2aIL-6\u5bb6\u65cf\u7ec6\u80de\u56e0\u5b50\u4fe1\u53f7\u901a\u8def\uff0c\u4ee5\u6291\u5236\u5176\u5bf9\u80bf\u7624\u751f\u957f\u3001\u8f6c\u79fb\u7684\u4fc3\u8fdb\u4f5c\u7528\u548c\u5bf9\u5316\u7597\u7684\u6297\u836f\u6027\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cHBM9014\u8868\u73b0\u51fa\u663e\u8457\u7684\u4f53\u5185\u6297\u80bf\u7624\u7597\u6548\uff0c\u5e76\u4e14\u5728\u591a\u79cd\u80bf\u7624\u6a21\u578b\u4e2d\u4e0e\u987a\u94c2\u8054\u7528\u7597\u6548\u66f4\u4f73\u3002\u5728\u7075\u957f\u7c7b\u52a8\u7269\u7684\u6bd2\u7406\u5b66\u7814\u7a76\u4e2d\uff0cHBM9014\u4e5f\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u30022025\u5e74\uff0c\u516c\u53f8\u5c06\u7ee7\u7eed\u79ef\u6781\u63a2\u7d22\u836f\u7269\u5f00\u53d1\u7b56\u7565\u5e76\u5bfb\u6c42\u5408\u4f5c\u673a\u4f1a\u3002<\/p>\n<p>\u6218\u7565\u4e1a\u52a1\u5408\u4f5c\u6700\u5927\u5316\u5e73\u53f0\u4ef7\u503c<\/p>\n<p>\u548c\u94c2\u533b\u836f\u59cb\u7ec8\u81f4\u529b\u4e8e\u5168\u7403\u5408\u4f5c\uff0c\u8fd9\u4e3a\u5176\u79d1\u7814\u4e0e\u5546\u4e1a\u6210\u529f\u63d0\u4f9b\u4e86\u5f3a\u52b2\u52a8\u529b\u30022024\u5e74\uff0c\u516c\u53f8\u6301\u7eed\u62d3\u5c55\u4e0e\u5168\u7403\u9876\u5c16\u5b66\u672f\u673a\u6784\u53ca\u884c\u4e1a\u4f19\u4f34\u7684\u4e1a\u52a1\u5408\u4f5c\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u5171\u540c\u63a8\u52a8\u521b\u65b0\u4e0e\u6548\u7387\u63d0\u5347\u3002<\/p>\n<p>\u4f9d\u6258\u5e73\u53f0\u6280\u672f\u4f18\u52bf\uff0c\u516c\u53f8\u901a\u8fc7\u8bfa\u7eb3\u751f\u7269\u9ad8\u6548\u8d4b\u80fd\u884c\u4e1a\u521b\u65b0\u8005\uff0c\u4e3a\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b\u4ece\u53d1\u73b0\u81f3\u4e34\u5e8a\u524d\u7814\u53d1\u7b49Idea to IND\uff08I to ITM\uff09\u5b8c\u6574\u670d\u52a1\u3002\u4f5c\u4e3a\u4e00\u5bb6\u5168\u7403\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u8bfa\u7eb3\u751f\u7269\u81f4\u529b\u4e8e\u4e3a\u5305\u62ec\u79d1\u7814\u9662\u6240\u3001\u751f\u7269\u79d1\u6280\u521d\u521b\u4f01\u4e1a\u5230\u8de8\u56fd\u836f\u4f01\u5728\u5185\u7684\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b\u4e00\u7ad9\u5f0f\u89e3\u51b3\u65b9\u6848\u3002\u81ea2022\u5e74\u5e95\u6210\u7acb\u4ee5\u6765\uff0c\u8bfa\u7eb3\u751f\u7269\u5df2\u901a\u8fc7\u591a\u5143\u521b\u65b0\u5408\u4f5c\u6a21\u5f0f\u8fbe\u6210\u591a\u9879\u56fd\u9645\u6218\u7565\u5408\u4f5c\uff0c\u5e76\u57fa\u4e8eHCAb\u6784\u5efa\u5f62\u6210\u56db\u5927\u524d\u6cbf\u6838\u5fc3\u6280\u672f\uff0c\u5305\u62ec\u86cb\u767d\u8d28\u5de5\u7a0b\u3001\u6297\u4f53\u5076\u8054\u6280\u672f\u3001\u836f\u7269\u9012\u9001\u6280\u672f\u548c\u7ec6\u80de\u6cbb\u7597\uff0c\u5168\u9762\u8d4b\u80fd\u65b0\u4e00\u4ee3\u7597\u6cd5\u5f00\u53d1\u3002<\/p>\n<p>2024\u5e745\u6708\uff0c\u8bfa\u7eb3\u751f\u7269\u4e0e\u963f\u65af\u5229\u5eb7\u7b7e\u7f72\u5168\u7403\u8bb8\u53ef\u53ca\u9009\u62e9\u6743\u534f\u8bae\uff0c\u5171\u540c\u5f00\u53d1\u7528\u4e8e\u80bf\u7624\u9776\u5411\u6cbb\u7597\u7684\u4e34\u5e8a\u524d\u5355\u514b\u9686\u6297\u4f53\u3002\u540c\u5e7412\u6708\uff0c\u8bfa\u7eb3\u751f\u7269\u4e0eCandid Therapeutics\u8fbe\u6210\u7814\u7a76\u5408\u4f5c\u53ca\u8bb8\u53ef\u534f\u8bae\uff0c\u63a2\u7d22\u65b0\u4e00\u4ee3T\u7ec6\u80de\u8854\u63a5\u5668\u6280\u672f\u3002\u6b64\u5916\uff0c\u8fc7\u53bb\u4e00\u5e74\uff0c\u8bfa\u7eb3\u751f\u7269\u8fd8\u4e0eBoostimmune\u3001Alaya.bio\u3001Umoja Biopharma\u3001Alkyon Therapeutics\u3001OverT Bio \u548c Kodiak Sciences\u7b49\u591a\u5bb6\u5408\u4f5c\u4f19\u4f34\u5728\u591a\u4e2a\u6cbb\u7597\u9886\u57df\u5f00\u5c55\u7814\u7a76\u5408\u4f5c\u3002<\/p>\n<p>2025\u5e741\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u4e0eWindward Bio\u5c31\u9776\u5411TSLP\u5168\u4eba\u6e90\u6297\u4f53HBM9378\u7b7e\u8ba2\u8bb8\u53ef\u534f\u8bae\uff0c\u52a0\u901f\u514d\u75ab\u6027\u75be\u75c5\u7597\u6cd5\u5f00\u53d1\u30022025\u5e742\u6708\uff0c\u516c\u53f8\u5b75\u5316\u7684\u521b\u65b0\u751f\u7269\u6280\u672f\u516c\u53f8HBM Alpha Therapeutics\u5ba3\u5e03\u4e0e\u4e00\u5bb6\u4e1a\u52a1\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u4e0e\u8bb8\u53ef\u534f\u8bae\uff0c\u5171\u540c\u63a8\u8fdb\u9488\u5bf9\u591a\u79cd\u75be\u75c5\u7684\u65b0\u578b\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\uff08CRH\uff09\u9776\u5411\u7597\u6cd5\u3002<\/p>\n<p>\u8fd9\u4e9b\u5408\u4f5c\u6848\u4f8b\u8fdb\u4e00\u6b65\u51f8\u663e\u4e86\u516c\u53f8\u5728\u62d3\u5c55\u6280\u672f\u8fb9\u754c\u4e0e\u63a2\u7d22\u521b\u65b0\u8def\u5f84\u65b9\u9762\u7684\u72ec\u7279\u4f18\u52bf\u3002\u51ed\u501f\u4e1a\u754c\u9886\u5148\u7684\u6280\u672f\u5e73\u53f0\u548c\u7075\u6d3b\u7684\u5546\u4e1a\u6a21\u5f0f\uff0c\u516c\u53f8\u5c06\u6301\u7eed\u62d3\u5bbd\u5408\u4f5c\u7f51\u7edc\uff0c\u5b9e\u73b0\u5e73\u53f0\u4ef7\u503c\u6700\u5927\u5316\u3002<\/p>\n<p>\u4ee5\u5c16\u7aef\u5408\u4f5c\u9a71\u52a8\u521b\u65b0\u5b75\u5316<\/p>\n<p>\u548c\u94c2\u533b\u836f\u6301\u7eed\u63a2\u7d22\u6280\u672f\u5e73\u53f0\u7684\u66f4\u591a\u5e94\u7528\u573a\u666f\uff0c\u4ee5\u5145\u5206\u91ca\u653e\u5176\u6f5c\u529b\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u5b75\u5316\u591a\u4e2a\u5408\u8d44\u9879\u76ee\uff0c\u805a\u7126\u591a\u4ef7\u6297\u4f53\u3001\u7ec6\u80de\u6cbb\u7597\u7b49\u65b0\u4e00\u4ee3\u521b\u65b0\u7597\u6cd5\u9886\u57df\uff0c\u65e8\u5728\u901a\u8fc7\u62d3\u5c55\u6280\u672f\u5e73\u53f0\u7684\u5e94\u7528\u8303\u56f4\uff0c\u4e3a\u516c\u53f8\u521b\u9020\u66f4\u591a\u4ef7\u503c\u3002\u8fd9\u79cd\u521b\u65b0\u7684\u5b75\u5316\u6a21\u5f0f\u80fd\u591f\u6574\u5408\u5916\u90e8\u8d44\u6e90\uff0c\u4ee5\u6700\u5c0f\u7684\u8fb9\u9645\u6295\u5165\u83b7\u5f97\u9ad8\u4ef7\u503c\u589e\u957f\u56de\u62a5\uff0c\u52a9\u529b\u516c\u53f8\u5b9e\u73b0\u65b0\u4e00\u4ee3\u521b\u65b0\u6280\u672f\u7684\u591a\u5143\u5316\u5e03\u5c40\u3002\u5176\u4e2d\u5177\u6709\u4ee3\u8868\u6027\u7684\u5b75\u5316\u9879\u76ee\u5305\u62ecHBM Alpha Therapeutics\u548c\u6069\u51ef\u8d5b\u836f\u3002<\/p>\n<p>2025\u5e74\u5c55\u671b\uff1a\u5168\u7403\u5316\u53d1\u5c55\u4e0e\u7a81\u7834\u6027\u521b\u65b0\u5e76\u4e3e<\/p>\n<p>\u5c55\u671b\u672a\u6765\uff0c\u548c\u94c2\u533b\u836f\u5c06\u7ee7\u7eed\u901a\u8fc7\u548c\u94c2\u533b\u7597\u548c\u8bfa\u7eb3\u751f\u7269\u7684&#8221;\u53cc\u5f15\u64ce&#8221; \u9a71\u52a8\u4e1a\u52a1\u589e\u957f\u30022025\u5e74\uff0c\u548c\u94c2\u533b\u7597\u5c06\u6301\u7eed\u63a8\u8fdb\u5185\u90e8\u7ba1\u7ebf\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u8fdb\u7a0b\uff0c\u8bfa\u7eb3\u751f\u7269\u5c06\u7ee7\u7eed\u4e3a\u751f\u7269\u79d1\u6280\u53ca\u5236\u836f\u4f01\u4e1a\u63d0\u4f9b\u4e00\u4f53\u5316\u7814\u53d1\u89e3\u51b3\u65b9\u6848\uff0c\u4e0d\u65ad\u5b8c\u5584\u4fc3\u8fdb\u751f\u7269\u533b\u836f\u53d1\u5c55\u7684\u521b\u65b0\u751f\u6001\u5708\u5efa\u8bbe\u3002<\/p>\n<p>\u57fa\u4e8e\u516c\u53f8Harbour Mice\u00ae\u6280\u672f\u5e73\u53f0\u53caT\u7ec6\u80de\u8854\u63a5\u5668\u6280\u672f\u5f00\u53d1\u7684\u591a\u6b3e\u4ea7\u54c1\u5c06\u5411\u514d\u75ab\u5b66\u9886\u57df\u62d3\u5c55\uff0cADC\u5e73\u53f0\u4e5f\u5c06\u5b8c\u6210\u8fed\u4ee3\u5347\u7ea7\u3002\u901a\u8fc7\u81ea\u4e3b\u5f00\u53d1\u4e0e\u5546\u4e1a\u5408\u4f5c\u76f8\u7ed3\u5408\u7684\u65b9\u5f0f\uff0c\u516c\u53f8\u8ba1\u5212\u5728\u514d\u75ab\u6027\u75be\u75c5\u53ca\u514d\u75ab\u80bf\u7624\u9886\u57df\u6253\u9020\u5177\u6709\u5dee\u5f02\u5316\u7ade\u4e89\u4f18\u52bf\u7684\u4ea7\u54c1\u7ec4\u5408\u3002<\/p>\n<p>\u901a\u8fc7\u6218\u7565\u5408\u4f5c\u5b9e\u73b0\u5e73\u53f0\u4ef7\u503c\u6700\u5927\u5316\u7684\u5546\u4e1a\u6a21\u5f0f\u5c06\u6301\u7eed\u63a8\u52a8\u516c\u53f8\u5168\u7403\u5316\u53d1\u5c55\u30022025\u5e74\uff0c\u968f\u7740\u4e34\u5e8a\u524d\u4ea7\u54c1\u7ba1\u7ebf\u9010\u6e10\u6210\u719f\uff0c\u516c\u53f8\u6709\u671b\u8fdb\u4e00\u6b65\u6269\u5927\u5408\u4f5c\u7f51\u7edc\uff0c\u5efa\u7acb\u66f4\u4e3a\u5e7f\u6cdb\u7684\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u5de9\u56fa\u5176\u5728\u5168\u7403\u5e02\u573a\u7684\u9886\u5148\u5730\u4f4d\u3002<\/p>\n<p>\u5173\u4e8e\u548c\u94c2\u533b\u836f<\/p>\n<p>\u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u514d\u75ab\u6027\u75be\u75c5\u53ca\u80bf\u7624\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u56fd\u9645\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002<\/p>\n<p>\u548c\u94c2\u533b\u836f\u4e13\u6709\u7684\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour Mice\u00ae\u80fd\u591f\u751f\u6210\u53cc\u91cd\u3001\u53cc\u8f7b\u94fe\uff08H2L2\uff09\u548c\u4ec5\u91cd\u94fe\uff08HCAb\uff09\u5f62\u5f0f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u57fa\u4e8eHCAb\u6297\u4f53\u5e73\u53f0\u5f00\u53d1\u7684\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\uff08HBICE\u00ae\uff09\u80fd\u591f\u5b9e\u73b0\u4f20\u7edf\u836f\u7269\u8054\u5408\u7597\u6cd5\u65e0\u6cd5\u8fbe\u5230\u7684\u6297\u80bf\u7624\u7597\u6548\u3002\u540c\u65f6\uff0c\u57fa\u4e8eHCAb\u5e73\u53f0\u5f00\u53d1\u7684\u53cc\u7279\u5f02\u6027\u514d\u75ab\u7ec6\u80de\u62ee\u6297\u5242\uff08HBICATM\uff09\u4e3a\u514d\u75ab\u53ca\u708e\u75c7\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u751f\u7269\u836f\u7684\u7814\u53d1\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6301\u3002Harbour Mice\u00ae\u3001HBICE\u00ae\u3001HBICATM\u4e0e\u5355B\u7ec6\u80de\u514b\u9686\u7b5b\u9009\u5e73\u53f0\u5171\u540c\u7ec4\u6210\u4e86\u548c\u94c2\u7684\u4e0b\u4e00\u4ee3\u521b\u65b0\u6cbb\u7597\u6027\u6297\u4f53\u7814\u53d1\u5f15\u64ce\u3002\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u8bbf\u95ee\uff1a<a href=\"http:\/\/www.harbourbiomed.com\/\" target=\"_blank\" rel=\"noopener\">www.harbourbiomed.com<\/a>\u3002<\/p>\n<p>SOURCE  \u548c\u94c2\u533b\u836f<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u4e0a\u6d77\u3001\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u548c\u8377\u5170\u9e7f\u7279\u4e392025\u5e743\u670831\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u514d\u75ab\u6027\u75be\u75c5\u53ca\u80bf\u7624\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u516c\u5e03\u51762024\u5e74\u5ea6\u4e1a\u7ee9\u3002 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Neurology\uff09\u4e0a\u53d1\u8868\uff0c\u6570\u636e\u663e\u793a\u5176\u5728\u75be\u75c5\u957f\u671f\u7ba1\u7406\u4e2d\u5177\u6709\u6301\u7eed\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002 HBM9378\u662f\u4e00\u6b3e\u6e90\u81eaH2L2 Harbour Mice\u00ae\u5e73\u53f0\uff0c\u9776\u5411\u80f8\u817a\u57fa\u8d28\u6dcb\u5df4\u7ec6\u80de\u751f\u6210\u7d20\uff08TSLP\uff09\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u7531\u548c\u94c2\u533b\u836f\u4e0e\u79d1\u4f26\u535a\u6cf0\u5171\u540c\u5f00\u53d1\u5e76\u5e73\u5206\u5176\u6743\u76ca\u3002\u4e0e\u540c\u9776\u70b9\u7ade\u4e89\u4ea7\u54c1\u76f8\u6bd4\uff0cHBM9378\u5177\u6709\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u98ce\u9669\u53ca\u66f4\u597d\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u8f83\u957f\u7684\u534a\u8870\u671f\u4f18\u5316\u8bbe\u8ba1\u548c\u4f18\u79c0\u7684\u7406\u5316\u6027\u8d28\u4f7f\u5f97HBM9378\u5728\u7ed9\u836f\u548c\u5242\u578b\u65b9\u9762\u62e5\u6709\u6f5c\u5728\u4f18\u52bf\u3002 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Neurology\uff09\u4e0a\u53d1\u8868\uff0c\u6570\u636e\u663e\u793a\u5176\u5728\u75be\u75c5\u957f\u671f\u7ba1\u7406\u4e2d\u5177\u6709\u6301\u7eed\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002 HBM9378\u662f\u4e00\u6b3e\u6e90\u81eaH2L2 Harbour Mice\u00ae\u5e73\u53f0\uff0c\u9776\u5411\u80f8\u817a\u57fa\u8d28\u6dcb\u5df4\u7ec6\u80de\u751f\u6210\u7d20\uff08TSLP\uff09\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u7531\u548c\u94c2\u533b\u836f\u4e0e\u79d1\u4f26\u535a\u6cf0\u5171\u540c\u5f00\u53d1\u5e76\u5e73\u5206\u5176\u6743\u76ca\u3002\u4e0e\u540c\u9776\u70b9\u7ade\u4e89\u4ea7\u54c1\u76f8\u6bd4\uff0cHBM9378\u5177\u6709\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u98ce\u9669\u53ca\u66f4\u597d\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5176\u8f83\u957f\u7684\u534a\u8870\u671f\u4f18\u5316\u8bbe\u8ba1\u548c\u4f18\u79c0\u7684\u7406\u5316\u6027\u8d28\u4f7f\u5f97HBM9378\u5728\u7ed9\u836f\u548c\u5242\u578b\u65b9\u9762\u62e5\u6709\u6f5c\u5728\u4f18\u52bf\u3002 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Bio\u6b63\u5728\u7b79\u5907HBM9378\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u666e\u9c81\u82cf\u62dc\u5355\u6297\uff08HBM4003\uff09\u662f\u5f00\u53d1\u81eaHCAb Harbour Mice\u00ae\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\uff0c\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297\u4f53\u3002\u76f8\u8f83\u4e8e\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u5177\u6709\u663e\u8457\u589e\u52a0\u7684Treg\u7ec6\u80de\u6e05\u9664\u548c\u4f18\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u72ec\u7279\u53ca\u826f\u597d\u7684\u7279\u6027\uff0c\u6709\u52a9\u4e8e\u63d0\u9ad8\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u589e\u5f3a\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u666e\u9c81\u82cf\u62dc\u5355\u6297\u63d0\u5347\u4e86\u9009\u62e9\u6027\u6e05\u9664\u7624\u5185Treg\u7ec6\u80de\u7684\u6f5c\u529b\uff0c\u6709\u671b\u514b\u670d\u73b0\u6709CTLA-4\u7597\u6cd5\u7684\u7597\u6548\u548c\u6bd2\u6027\u74f6\u9888\u3002\u516c\u53f8\u5df2\u5f00\u5c55\u666e\u9c81\u82cf\u62dc\u5355\u6297\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u5168\u7403\u5f00\u53d1\u8ba1\u5212\uff0c\u5e76\u91c7\u7528\u4e86\u666e\u9c81\u82cf\u62dc\u5355\u6297\u7684\u9002\u5e94\u6027\u6cbb\u7597\u8bbe\u8ba1\u3002\u5728\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u7684\u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u8054\u5408PD-1\u6291\u5236\u5242\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u764c\u53ca\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u79ef\u6781\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u6570\u636e\u3002 HBM1020\u662f\u4e00\u6b3e\u57fa\u4e8eH2L2 Harbour 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